                         SEQUENCE LISTING

<110>  Ortho-Clinical Diagnostics, Inc.
       Janssen Pharmaceutica NV
 
<120>  Antibodies to Olanzapine and Use Thereof

<130>  CDS5133WOPCT

<150>  US 61/691,645
<151>  2012-08-21

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  1
atggaatcac agactcaggt cctcatgtcc ctgctgctct ggatatctgg tacctatggg       60

gacattgtga tgacacagtc tccatcctcc ctgagtgtgg caacaggaga taaggtcact      120

atgagctgca agtccagtca gagtctgttc aacagtagaa accaaaagag ctacttggcc      180

tggtaccagc agaagccatg gcagcctcct aaactgctga tctacggggc atccactagg      240

gaatctgggg tccctgatcg cttcacaggc agtggatctg gaacagattt cactctcacc      300

atcagcagtg tgcaggctga agacctggca atttattact gtcagaatga ttatagttat      360

ccattcacgt tcggcacggg gacaaaattg gaaataaga                             399


<210>  2
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  2
atgggattca gcaggatctt tctcttcctc ctgtcagtaa ctacaggtgt ccactcccag       60

gcttttctac aacaatctgg ggctgagctg gtgaggcctg gggcctcagt gaagatgtcc      120

tgcaaggcct ctggctccac atttaccagt tacaatatac actgggtcaa gcagacacct      180

agacagggcc tggaatggat tggagctatt tatccaggaa atggtgatac ttcctacaat      240

cagaagttca agggcagggc cacactgact atagacaaat cctccagcac agcctacatg      300

cagctcagca gcctgacatc tgaagactct gcggtctatt tctgtgctaa ctggggcttt      360

gagtactggg gtcaaggcac cactctctca gtctcctca                             399


<210>  3
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  3

Met Glu Ser Gln Thr Gln Val Leu Met Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Thr Tyr Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Val Ala Thr Gly Asp Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Phe Asn Ser Arg Asn Gln Lys Ser Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Trp Gln Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Thr Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Arg 
    130             


<210>  4
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  4

Met Gly Phe Ser Arg Ile Phe Leu Phe Leu Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ala Phe Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Ser Thr Phe 
        35                  40                  45              


Thr Ser Tyr Asn Ile His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Ile Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Asn Trp Gly Phe Glu Tyr Trp Gly Gln Gly Thr Thr 
        115                 120                 125             


Leu Ser Val Ser Ser 
    130             


<210>  5
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  5
atggaatcac agactcaggt cctcatgtcc ctgctgctct ggatatctgg tacctatggg       60

gacattgtga tgacacagtc tccatcctcc ctgagtgtgg caacaggaga taaggtcact      120

atgagctgca agtccagtca gagtctgttc aacagtagaa accaaaagag ctacttggcc      180

tggtaccagc agaagccatg gcagcctcct aaactgctga tctacggggc atccactagg      240

gaatctgggg tccctgatcg cttcacaggc agtggatctg gaacagattt cactctcacc      300

atcagcagtg tgcaggctga agacctggca atttattact gtcagaatga ttatagttat      360

ccattcacgt tcggcacggg gacaaaattg gaaataaga                             399


<210>  6
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  6
atgggattca gcaggatctt tctcttcctc ctgtcagtaa ctacaggtgt ccactcccag       60

gcttttctac aacaatctgg ggctgagctg gtgaggcctg gggcctcagt gaagatgtcc      120

tgcaaggcct ctggctccac atttaccagt tacaatatac actgggtcaa gcagacacct      180

agacagggcc tggaatggat tggagctatt tatccaggaa atggtgatac ttcctacaat      240

cagaagttca agggcagggc cacactgact atagacaaat cctccagcac agcctacatg      300

cagctcagca gcctgacatc tgaagactct gcggtctatt tctgtgctaa ctggggcttt      360

gagtactggg gtcaaggcac cactctctca gtctcctca                             399


<210>  7
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  7

Met Glu Ser Gln Thr Gln Val Leu Met Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Thr Tyr Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Val Ala Thr Gly Asp Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Phe Asn Ser Arg Asn Gln Lys Ser Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Trp Gln Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Thr Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Arg 
    130             


<210>  8
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  8

Met Gly Phe Ser Arg Ile Phe Leu Phe Leu Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ala Phe Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Ser Thr Phe 
        35                  40                  45              


Thr Ser Tyr Asn Ile His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Ile Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Asn Trp Gly Phe Glu Tyr Trp Gly Gln Gly Thr Thr 
        115                 120                 125             


Leu Ser Val Ser Ser 
    130             


<210>  9
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  9
atggagtcac agactcaggt ctttgtattc gtgttgctct ggttgtctgg tggagatgga       60

gacattgtga tgacccagtc tcaaaaattc atgtccacat cactaggaga cagggtcagc      120

atcacctgca aggccagtca gaatgtggga atttatgttt cctggtatca acagaaacca      180

gggaaatctc ctaaagcact aatttactgg tcttcaaacc ggttcactgg agtccctgat      240

cgtttcacag gcagtggatc tgggacagac ttcactctca ccatcaccga tgtgcagtct      300

gaagacttgg cagattattt ctgtgagcaa tatagcagcg atccgtatac gttcggatcg      360

gggaccaagc tggaaataaa a                                                381


<210>  10
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  10
atggaaagac actggatctt tctcttcctg ttgtcagtaa ctgcaggtgt ccactcccag       60

gtccaactgc agcagtctgc ggctgaactg gcaagacctg gggcctcagt gaagatgtcc      120

tgcaagactt ctggctacac cttcactagc gaccggatgc actgggtaat acagaggcct      180

ggacagggtc tggagtggat tggatacatt cttcctagaa atgtttatac taaatacaat      240

aaaaagttca aggacaaggc cacattgact gcagacacat cctccagtat agcctacatc      300

caactgagca gcctgacatc tgaagactct gcagtctatt actgtgtaaa gtctgacggg      360

ggctactggg gccaaggcac cactctcaca gtctcctca                             399


<210>  11
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  11

Met Glu Ser Gln Thr Gln Val Phe Val Phe Val Leu Leu Trp Leu Ser 
1               5                   10                  15      


Gly Gly Asp Gly Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Leu Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn 
        35                  40                  45              


Val Gly Ile Tyr Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro 
    50                  55                  60                  


Lys Ala Leu Ile Tyr Trp Ser Ser Asn Arg Phe Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr 
                85                  90                  95      


Asp Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Glu Gln Tyr Ser 
            100                 105                 110         


Ser Asp Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  12
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  12

Met Glu Arg His Trp Ile Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Ala Ala Glu Leu Ala Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Asp Arg Met His Trp Val Ile Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Leu Pro Arg Asn Val Tyr Thr Lys Tyr Asn 
65                  70                  75                  80  


Lys Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser 
                85                  90                  95      


Ile Ala Tyr Ile Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Val Lys Ser Asp Gly Gly Tyr Trp Gly Gln Gly Thr Thr 
        115                 120                 125             


Leu Thr Val Ser Ser 
    130             


<210>  13
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  13
atggagtcac agactcaggt ctttgtattc gtgttgctct ggttgtctgg tggtgatgga       60

gacattgtga tgacccagtc tcaaaaattc atgtccacat cactaggaga cagggtcagc      120

atcacctgca aggccagtca gaatgtggga atttatgtat cctggtatca acagaaacca      180

gggaaatctc ctaaagcact aatttattgg gcatcaaacc ggttcactgg agtccctgat      240

cgcttcacag gcagtggatc tgggacagac ttcactctca ccatcaccaa tgtgcagtct      300

gaagacttgg cagaatattt ctgtgaacaa tatagcagcg atccgtatac gttcggatcg      360

gggaccaagc tagaaataaa a                                                381


<210>  14
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  14
atggaaaggc actggatctt tctcttcctg ttgtcagtaa ctgcaggtgt ccactcccag       60

gtccaactgc agcagtctgc ggctgaactg gtaagacctg gggcctcagt gaagatgtcc      120

tgcaagactt ctggctacat cttcactagc gaccggatgc actgggtaaa acagaggcct      180

ggacagggtc tggagtggat tggatacatt attcctagaa atttttatac taaatacaat      240

cagaaattca aggacaaggc cacattgact gcagacacat cctccaatac agcctacatg      300

cagttgagca gcctgacatc tgaagactct gcagtctatt actgtgtgaa atctgacggg      360

gcctactggg gccaaggcac cactctcaca gtctcctca                             399


<210>  15
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  15

Met Glu Ser Gln Thr Gln Val Phe Val Phe Val Leu Leu Trp Leu Ser 
1               5                   10                  15      


Gly Gly Asp Gly Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Leu Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn 
        35                  40                  45              


Val Gly Ile Tyr Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro 
    50                  55                  60                  


Lys Ala Leu Ile Tyr Trp Ala Ser Asn Arg Phe Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Glu Gln Tyr Ser 
            100                 105                 110         


Ser Asp Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  16
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  16

Met Glu Arg His Trp Ile Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Ala Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Ile Phe 
        35                  40                  45              


Thr Ser Asp Arg Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Ile Pro Arg Asn Phe Tyr Thr Lys Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Val Lys Ser Asp Gly Ala Tyr Trp Gly Gln Gly Thr Thr 
        115                 120                 125             


Leu Thr Val Ser Ser 
    130             


<210>  17
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  17
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagtagtgat       60

gttgtgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc      120

tcttgttggt ctagtcagag ccttgtagac agttatggaa acacctattt acattggtat      180

ctgcagaagc caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggaatttac ttttgctctc aaactacata tgttccgtat      360

acgttcggat cggggaccaa gctggaaatg aaa                                   393


<210>  18
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  18
atggaatgga cctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccactcccag       60

gttcagctgc accagtctgg agctgagctg atgaagcctg gggcctcagt gaagatatcc      120

tgcaaggcta ccggctacac atttagtagg tactggatag agtggataaa acagaggcct      180

ggccatggcc ttgagtggat tggagagttt ctacctggaa gtggaaattc taactacaat      240

gctaaattca agggcaaggc caccttcact gcagcaacat cctccaacac agcctacatg      300

caactcagca gtgtgacatc tgaagactct gccgtctatt tctgtgcaac ctggtacgat      360

gttaactacc gctatcttat ggactattgg ggtcaaggaa cctcagtcac cgtctcctca      420


<210>  19
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  19

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Trp Ser Ser Gln Ser Leu 
        35                  40                  45              


Val Asp Ser Tyr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Phe Cys 
            100                 105                 110         


Ser Gln Thr Thr Tyr Val Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu 
        115                 120                 125             


Glu Met Lys 
    130     


<210>  20
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  20

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu His Gln Ser Gly Ala Glu Leu Met Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe 
        35                  40                  45              


Ser Arg Tyr Trp Ile Glu Trp Ile Lys Gln Arg Pro Gly His Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Phe Leu Pro Gly Ser Gly Asn Ser Asn Tyr Asn 
65                  70                  75                  80  


Ala Lys Phe Lys Gly Lys Ala Thr Phe Thr Ala Ala Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Val Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Thr Trp Tyr Asp Val Asn Tyr Arg Tyr Leu Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140 


<210>  21
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  21
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat       60

attgtgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc      120

tcttgcaggt ctagtcagag ccttgtacgc agtaatggga acacctattt acattggtac      180

ctgcagaagc caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct      240

ggggtccccg acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggagtttat ttctgctctc aaagtacaca tgttccgtat      360

acgttcggat cggggaccaa gctggaaata aaa                                   393


<210>  22
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  22
atggaatgga cctgggtctt tctcttcctc ctgtcagtaa ccgcaggtgt ccactcccag       60

gttcagctgc agcagtctgg agctgtactg atgaagcctg gggcctcagt gaagatatcc      120

tgcaaggcta ctggctacac attcattagg tactggatag agtgggtaaa gaagaggcct      180

ggacatggcc ttgactggat tggagaaatt ttacctggaa gtggaagttc taactacaat      240

gagaacttca aggtcaaggc cactttcact gtagatactt cctccaacac agcctacatg      300

caactcaaca gcctgacatc tcaggactct gccgtctatt actgtgcaat ttggtacgat      360

ggtaattacc gctctcttat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      420


<210>  23
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  23

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val Arg Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Ser Gln Ser Thr His Val Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  24
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  24

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Val Leu Met Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe 
        35                  40                  45              


Ile Arg Tyr Trp Ile Glu Trp Val Lys Lys Arg Pro Gly His Gly Leu 
    50                  55                  60                  


Asp Trp Ile Gly Glu Ile Leu Pro Gly Ser Gly Ser Ser Asn Tyr Asn 
65                  70                  75                  80  


Glu Asn Phe Lys Val Lys Ala Thr Phe Thr Val Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Gln Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ile Trp Tyr Asp Gly Asn Tyr Arg Ser Leu Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140 


<210>  25
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  25
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat       60

attgtgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc      120

tcttgcaggt ctagtcagag ccttgtacgc agtaatggaa acacctattt acattggtac      180

ctgcagaagc caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct      240

ggggtccccg acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggagtttat ttctgctctc aaagtacaca tgttccgtat      360

acgttcggat cggggaccaa gctggaaata aaa                                   393


<210>  26
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  26
atggaatgga cctgggtctt tctcttcctc ctgtcagtaa ccgcaggtgt ccactcccag       60

gttcagctgc agcagtctgg agctgtactg atgaagcctg gggcctcagt gaagatatcc      120

tgcaaggcta ctggctacac attcattagg tactggatag agtgggtaaa gaagaggcct      180

ggacatggcc ttgactggat tggagaaatt ttacctggaa gtggaagttc taactacaat      240

gagaacttca aggtcaaggc cactttcact gtagatactt cctccaacac agcctacatg      300

caactcaaca gcctgacatc tcaggactct gccgtctatt actgtgcaat ttggtacgat      360

ggtaattacc gctctcttat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      420


<210>  27
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  27

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val Arg Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Ser Gln Ser Thr His Val Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  28
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  28

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Val Leu Met Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe 
        35                  40                  45              


Ile Arg Tyr Trp Ile Glu Trp Val Lys Lys Arg Pro Gly His Gly Leu 
    50                  55                  60                  


Asp Trp Ile Gly Glu Ile Leu Pro Gly Ser Gly Ser Ser Asn Tyr Asn 
65                  70                  75                  80  


Glu Asn Phe Lys Val Lys Ala Thr Phe Thr Val Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Gln Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ile Trp Tyr Asp Gly Asn Tyr Arg Ser Leu Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140 


<210>  29
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  29
atgagtgtgc ccactcaggt cctggcattg ctgctgctgt ggcttacaga tgccagatgt       60

gatatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc      120

atcacatgtc gagcaagtgg gaatattcac aattatttag catggtatca gcagaaacag      180

ggaaaatctc ctcagctcct ggtctataat gcaaaaacct tagcggaagg tgtgccatca      240

aggttcagtg gcagtggatc aggaacacaa tattctctca agatcaacag cctgcagcct      300

gaggattttg ggacttatta ctgtcttcat tattacaata ttccgctcac gttcggtgct      360

gggaccacgc tggagctgaa a                                                381


<210>  30
<211>  414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  30
atgagagtgc tgattctttt gtggctgttc acagcctttc ctggtttcct gtctgatgtg       60

cagcttcagg agtcaggacc tggcctggtg aaaccttctc agtctctgtc cgtcacctgc      120

actgtcactg gctactccat catcagtggt tattactgga actggatccg gcagtttcca      180

ggaaacaaac tggagtggct gggctccata cacaacagtg gtcgcactaa ctacaatcca      240

tctctcaaaa gtcgaatctc tatcagtcga gacacatcca agaaccaatt cttcctgcag      300

ctggattctg tgactactga ggacacagcc acatattact gtcacttggg ggacgatggt      360

acctactctg ctatggacta ctggggtcaa ggaacctcag tcaccgtctc ctca            414


<210>  31
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  31

Met Ser Val Pro Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn 
        35                  40                  45              


Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro 
    50                  55                  60                  


Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Gly Thr Tyr Tyr Cys Leu His Tyr Tyr 
            100                 105                 110         


Asn Ile Pro Leu Thr Phe Gly Ala Gly Thr Thr Leu Glu Leu Lys 
        115                 120                 125         


<210>  32
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  32

Met Arg Val Leu Ile Leu Leu Trp Leu Phe Thr Ala Phe Pro Gly Phe 
1               5                   10                  15      


Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Ser Leu Ser Val Thr Cys Thr Val Thr Gly Tyr Ser Ile Ile 
        35                  40                  45              


Ser Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu 
    50                  55                  60                  


Glu Trp Leu Gly Ser Ile His Asn Ser Gly Arg Thr Asn Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Ile Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Phe Leu Gln Leu Asp Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys His Leu Gly Asp Asp Gly Thr Tyr Ser Ala Met Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135             


<210>  33
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  33
atgaggaccc ctgctcagtt tcttggaatc ttgttgctct ggtttccagg tatcaagtgt       60

gacatcaaga tgacccagtc tccatcttcc atgtatgcat ctctaggaga gagagtcact      120

atctcttgca aggcgagtca ggacattaat cgctatttaa gctggttcct gcagaaacca      180

gggaaatctc ctaagaccct gatctatcgt acaaacagat tagtagatgg ggtcccatca      240

aggttcagtg gcagtggatc tggacaagat tattctctca ccatcagcag cctggagtat      300

gaagatttgg gaatttatta ttgtctacat tatgctgagt ttcctcccac gttcggtgct      360

gggactaagc tggagctgaa a                                                381


<210>  34
<211>  414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  34
atgtacttgg gactgaactg tgtattcata gtttttctct taaaaggtgt ccagagtgaa       60

gtgaaacttg aggagtctgg aggaggcttg gtacaacctg gaggatccat gaaactctcc      120

tgtgttgcct ctggattcat tttcagtaac tactggatgg actggatccg ccagtctcca      180

gagaagggac ttgagtgggt tgctcaaatt agattgagat ctaataatta tgcgacacat      240

tatgcggagt ctttgaaagg gaggttcacc atctcaagag atgattccaa aagtactgtc      300

tacctgcaaa tgaacagttt aagaactgaa gactctggca tttattactg tacgaggact      360

atgattacga cacccagcta ctggggccaa ggcaccactc tcacagtctc ctca            414


<210>  35
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  35

Met Arg Thr Pro Ala Gln Phe Leu Gly Ile Leu Leu Leu Trp Phe Pro 
1               5                   10                  15      


Gly Ile Lys Cys Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Thr Ile Ser Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile Asn Arg Tyr Leu Ser Trp Phe Leu Gln Lys Pro Gly Lys Ser Pro 
    50                  55                  60                  


Lys Thr Leu Ile Tyr Arg Thr Asn Arg Leu Val Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Tyr Glu Asp Leu Gly Ile Tyr Tyr Cys Leu His Tyr Ala 
            100                 105                 110         


Glu Phe Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125         


<210>  36
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  36

Met Tyr Leu Gly Leu Asn Cys Val Phe Ile Val Phe Leu Leu Lys Gly 
1               5                   10                  15      


Val Gln Ser Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Ile Phe 
        35                  40                  45              


Ser Asn Tyr Trp Met Asp Trp Ile Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Gln Ile Arg Leu Arg Ser Asn Asn Tyr Ala Thr His 
65                  70                  75                  80  


Tyr Ala Glu Ser Leu Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Ser 
            100                 105                 110         


Gly Ile Tyr Tyr Cys Thr Arg Thr Met Ile Thr Thr Pro Ser Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135             


<210>  37
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  37
atgagtgtgc ccactcaggt cctggcattg ctgctgctgt ggcttacaga tgccagatgt       60

gatatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc      120

atcacatgtc gagcaagtgg gaatattcac aattatttag catggtatca gcagaaacag      180

ggaaaatctc ctcagctcct ggtctataat acaaaatcct tggcggaagg tgtgccatca      240

aggttcagtg gcagtggatc aggaacacaa tattctctca agatctacag cctgcagcct      300

gcggattttg gggcttatta ctgtcttcat tattataata ctccgctcac tttcggtgct      360

gggaccaagc tagagctgag a                                                381


<210>  38
<211>  414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  38
atgagagtgc tgattctttt gtggctgttc acagcctttc ctggtatcct gtctgatgtg       60

cagcttcagg agtcaggacc tggcctggtg aaaccttctc agtctctgtc cgtcacctgc      120

actgtcactg gcttctccat caccagtggt tattactgga actggatccg gcagtttcca      180

ggaaacaaac tggagtggat gggctacata cacaacagtg gtcgcactaa ctacaatcca      240

tctctcaaaa gtcgaatctc tatcactcga gacacatcca aaaaccagtt cttcctgcag      300

ttgagttctg tgactaatgc ggacacagcc acatattact gtcacttggg ggacgatggt      360

acctcctatg ctatggacta ctggggtcaa ggaacctcag tcaccgtctc ctca            414


<210>  39
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  39

Met Ser Val Pro Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn 
        35                  40                  45              


Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro 
    50                  55                  60                  


Gln Leu Leu Val Tyr Asn Thr Lys Ser Leu Ala Glu Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Tyr 
                85                  90                  95      


Ser Leu Gln Pro Ala Asp Phe Gly Ala Tyr Tyr Cys Leu His Tyr Tyr 
            100                 105                 110         


Asn Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg 
        115                 120                 125         


<210>  40
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  40

Met Arg Val Leu Ile Leu Leu Trp Leu Phe Thr Ala Phe Pro Gly Ile 
1               5                   10                  15      


Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Ser Leu Ser Val Thr Cys Thr Val Thr Gly Phe Ser Ile Thr 
        35                  40                  45              


Ser Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile His Asn Ser Gly Arg Thr Asn Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Phe Leu Gln Leu Ser Ser Val Thr Asn Ala Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys His Leu Gly Asp Asp Gly Thr Ser Tyr Ala Met Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135             


<210>  41
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  41
atggattttc aggtgcagat tttcagcttc ctgctaatca gtgcctcagt catactgtcc       60

agaggacaaa ttgttctcac ccagtctcca gcaatcatgt ctgcatctct gggggaggag      120

atcaccctaa cctgcagtgc cagctcgagt gtaaattaca tgcactggta ccagcagaag      180

tcaggcactt ctcccaaact cttgatttat agcacatcca acctggcttc tggagtccct      240

tctcgcttca gtggcagtgg gtctgggacc ttttattctc tcacaatcag cagtgtggag      300

gctgaagatg ctgccgatta ttactgccat cagtggagta gttatccgta cacgttcgga      360

ggggggacca agctggaaat aaaa                                             384


<210>  42
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  42
atggaatgga gttggatatt tctctttctc ctgtcaggaa ctgcaggtgt ccactctgag       60

gtccagttgc agcagtctgg acctgagctg gtaaagcctg gggcttcagt gaagatgtcc      120

tgcaaggctt ctggatacac attcactaac tatgttattt actgggtgaa gcagaagcct      180

gggcagggcc ttgagtggat tggatatatt aatccttaca atgatggtac taagtacaat      240

gagaagttca aaggcaaggc cacactgact gcagacaaat cctccagcac agcctacatg      300

gagctcagta gcctgacctc tgaggactct gcggtctatt actgtgcctg taacttcctc      360

tatgctatgg actactgggg tcaaggaacc tcagtcaccg tctcctca                   408


<210>  43
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  43

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Leu Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Leu Gly Glu Glu Ile Thr Leu Thr Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Val Asn Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Phe Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Val Glu Ala Glu Asp Ala Ala Asp Tyr Tyr Cys His Gln Trp 
            100                 105                 110         


Ser Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


<210>  44
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  44

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Val Ile Tyr Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Cys Asn Phe Leu Tyr Ala Met Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Ser Val Thr Val Ser Ser 
    130                 135     


<210>  45
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  45
atggagtcac agattcaggc atttgtattc gtgtttctct ggttgtctgg tgttgacgga       60

gacattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc      120

atcacctgca aggccagtca ggatgtgaat actgctgtag cctggtatca aaaaaaatta      180

ggacaatctc ctaaactgct gatttattgg gcatccaccc ggcacactgg agtccctgat      240

cgcttcacag gcagtggatc tgggacagat tatactctca ccatcagcag tgtgcaggct      300

gaagacctgg cactttatta ctgtcagcaa cattatagca ctccgtacac gttcggaggg      360

gggaccaagc tggaaataaa a                                                381


<210>  46
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  46
atgggatgga gctatatcat cctctttttg gtagcaacag ctacagatgt ccactcccag       60

gtccaactgc agcagcctgg ggctgaactg gtgacgcctg gggcttcagt gaagctgtcc      120

tgcaaggctt ctggctacac cttcaccagc tactggatgc actgggtgaa gcagaggcct      180

ggacaaggcc ttgagtggat tggagagatt aatcctggca acggtcgtac taactacaat      240

gataatttca tgatcagggc cacactgact gtggacaaat cctccagcac agcctacatg      300

caactcagca gcctgacatc tgaggactct gcggtctatt actgtgcaag aagcctctac      360

ggtaccctct ttgcttcctg gggccaaggg actctggtca ctgtctctgc a               411


<210>  47
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  47

Met Glu Ser Gln Ile Gln Ala Phe Val Phe Val Phe Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Asp Gly Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Asn Thr Ala Val Ala Trp Tyr Gln Lys Lys Leu Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Val Gln Ala Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Ser Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  48
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  48

Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Asp 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Thr 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Pro Gly Asn Gly Arg Thr Asn Tyr Asn 
65                  70                  75                  80  


Asp Asn Phe Met Ile Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Leu Tyr Gly Thr Leu Phe Ala Ser Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135         


<210>  49
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  49
atggagacag acacactcct gctatgggtg ctgctgctct gggttccagg ttccactggt       60

gacattgtac tgacacagtc tcctgtttcc ttaactattt ctctgggcca gagggccacc      120

atctcatgca gggccagcca aagtgtcagt gcatctagct atagttatat gcactggtac      180

caacagaaag caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct      240

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      300

cctgtggagg aggcggatac tgcaacatac tactgtcaac acaattggga ggttcctccg      360

acgttcggtg gaggcaccaa gctggaaatc aag                                   393


<210>  50
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  50
atggactcca ggctcaattt agttttcctt gtccttgttt taaaaggtgt ccagtgtgat       60

gtgcagttgg tggagtctgg gggaggctta gtgcagcctg gagggtcccg gaaactctcc      120

tgtgcagcct ctggattcac gttcagtagc tttggaatgc actgggttcg tcaggctcca      180

gagaaggggc tggaatgggt cgcatatatt agtagtggca gtagtaccat ctactataga      240

gacacagtga agggccgatt caccatctcc agagacaatc ccaagaacac cctgttcctg      300

caaatgacca gtctaaggtc tgaggacacg gccatgtatt actgtgcaag agggggggta      360

gtagtttcga aagatggaaa ctttgactac tggggccaag gcaccactct cgcagtctcc      420

tca                                                                    423


<210>  51
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  51

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Val Ser Leu Thr 
            20                  25                  30          


Ile Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ala Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Ala 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Asn Ile His Pro Val Glu Glu Ala Asp Thr Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln His Asn Trp Glu Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  52
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  52

Met Asp Ser Arg Leu Asn Leu Val Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Phe Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Arg 
65                  70                  75                  80  


Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn 
                85                  90                  95      


Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Gly Val Val Val Ser Lys Asp Gly Asn Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Ala Val Ser Ser 
    130                 135                 140     


<210>  53
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  53
atgatgtcct ctgctcagtt ccttggyctc ctgttgctct gttttcaagg taccagatgt       60

gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc      120

aycagttgca gtgcaagtca gggcattagc aattatttaa actggtatca gcagaaacca      180

gatggaactg ttaaactcct gatctattac acatcaagtt tacactcagg agtcccatca      240

aggttcagtg gcagtgggtc tgggacagat tattctctca ccatcagcaa cctggaacct      300

gaagatattg ccacttacta ttgtcagcag tatagtaagc ttccgtacac gttcggaggg      360

gggaccaaac tggaaataaa a                                                381


<210>  54
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  54
atggaaaggc actggatctt tctcttcctg ttgtcagtaa ctgcaggtgt ccactcccag       60

gtccaactgc agcagtctgc ggctgaactg gtaagacctg gggcctcagt gaagatgtcc      120

tgcaagactt ctggctacat cttcactagc gaccggatgc actgggtaaa acagaggcct      180

ggacagggtc tggagtggat tggatacatt attcctagaa atttttatac taaatacaat      240

cagaaattca aggacaaggc cacattgact gcagacacat cctccaatac agcctacatg      300

cagttgagca gcctgacatc tgaagactct gcagtctatt actgtgtgaa atctgacggg      360

gcctactggg gccaaggcac cactctcaca gtctcctca                             399


<210>  55
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence


<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa can be any naturally occurring amino acid

<400>  55

Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Xaa Ser Cys Ser Ala Ser Gln Gly 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser 
            100                 105                 110         


Lys Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  56
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  56

Met Glu Arg His Trp Ile Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Ala Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Ile Phe 
        35                  40                  45              


Thr Ser Asp Arg Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Ile Pro Arg Asn Phe Tyr Thr Lys Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Val Lys Ser Asp Gly Ala Tyr Trp Gly Gln Gly Thr Thr 
        115                 120                 125             


Leu Thr Val Ser Ser 
    130             


