                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
       Ho, Mitchell
       Pastan, Ira H.
       Phung, Yen
       Zhang, Yifan
       Gao, Wei
       Hassan, Raffit
 
<120>  MESOTHELIN DOMAIN-SPECIFIC MONOCLONAL ANTIBODIES AND USE THEREOF

<130>  4239-89390-02

<150>  US 61/691,719
<151>  2012-08-21

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  613
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  1

Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys Val 
1               5                   10                  15      


Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp Pro 
            20                  25                  30          


Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Ser Met Val 
        35                  40                  45              


Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala Ile Asp Asn Ala Leu 
    50                  55                  60                  


Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu Glu Gly Gly Val Glu 
65                  70                  75                  80  


Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg Gln Ala Arg Gly Ser 
                85                  90                  95      


Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His Glu Lys Pro Ser Asn 
            100                 105                 110         


Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly Asn Gln Leu Ser His 
        115                 120                 125             


Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp Glu Leu Leu Ala Lys 
    130                 135                 140                 


Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala His Glu Ser Asn Glu 
145                 150                 155                 160 


Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly Val Ser Val Val Met 
                165                 170                 175     


Ala Gln Thr Gln Pro Arg Arg Glu Lys Arg Trp Ser Glu Trp Ala Ser 
            180                 185                 190         


Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp Gly Val Tyr Asn Tyr 
        195                 200                 205             


Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr Trp Glu Gly Lys Ile 
    210                 215                 220                 


Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile Lys 
225                 230                 235                 240 


Pro Thr Val Ile Ser His Arg Leu His Phe Pro Glu Gly Gly Ser Leu 
                245                 250                 255     


Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe 
            260                 265                 270         


Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly 
        275                 280                 285             


Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser 
    290                 295                 300                 


Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly 
305                 310                 315                 320 


Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala 
                325                 330                 335     


Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg 
            340                 345                 350         


Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn Ala Asp Val Val 
        355                 360                 365             


Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys Ala Gly Pro Ala Asp 
    370                 375                 380                 


Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe 
385                 390                 395                 400 


Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn 
                405                 410                 415     


Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu Arg 
            420                 425                 430         


Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln 
        435                 440                 445             


Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala 
    450                 455                 460                 


Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly 
465                 470                 475                 480 


Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly 
                485                 490                 495     


Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr 
            500                 505                 510         


Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu 
        515                 520                 525             


Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly 
    530                 535                 540                 


Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu 
545                 550                 555                 560 


Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg 
                565                 570                 575     


Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln 
            580                 585                 590         


Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro 
        595                 600                 605             


Arg Glu Asp Leu Lys 
    610             


<210>  2
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His 
1               5                   10                  15      


Leu Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu 
            20                  25                  30          


Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr 
        35                  40                  45              


Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn 
    50                  55                  60                  


Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg 
65                  70                  75                  80  


Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu 
                85                  90                  95      


Ser Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala 
            100                 105                 110         


Ala Asn Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr 
        115                 120                 125             


Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser 
    130                 135                 140                 


Thr Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His 
145                 150                 155                 160 


Arg Gln Leu Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
                165                 170                 175     


Phe Leu Glu Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg 
            180                 185                 190         


Ser Gln Asp Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp 
        195                 200                 205             


Pro Ala Leu Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg 
    210                 215                 220                 


Gly Arg Ile Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser 
225                 230                 235                 240 


Ser Leu Pro Gly Phe Tyr Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu 
                245                 250                 255     


Ala Ala Gly Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg 
            260                 265                 270         


Leu Asp Ala Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr 
        275                 280                 285             


Ile Leu Gly Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala 
    290                 295                 300                 


Ile Pro Thr Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser 
305                 310                 315                 320 


Ile Pro Asp Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser 
                325                 330                 335     


Gln Pro Gly Lys Pro Pro Arg Glu Asp Leu Lys 
            340                 345         


<210>  3
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Pro Thr Gly Ala Glu 
1               5                   10                  15      


Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln 
            20                  25                  30          


Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu 
        35                  40                  45              


Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala 
    50                  55                  60                  


Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp 
65                  70                  75                  80  


Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr 
                85                  90                  95      


Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn 
            100                 105                 110         


Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe 
        115                 120                 125             


Tyr Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val 
    130                 135                 140                 


Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr 
145                 150                 155                 160 


Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro 
                165                 170                 175     


Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro 
            180                 185                 190         


Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu 
        195                 200                 205             


Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro 
    210                 215                 220                 


Pro Arg Glu Asp Leu Lys 
225                 230 


<210>  4
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Pro Thr Gly Ala Glu 
1               5                   10                  15      


Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln 
            20                  25                  30          


Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu 
        35                  40                  45              


Gly Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala 
    50                  55                  60                  


Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp 
65                  70                  75                  80  


Ala Ile Trp Ala Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr 
                85                  90                  95      


Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Ala Gly Arg Ile Arg Asn 
            100                 105                 110         


Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe 
        115                 120                 125             


Tyr Ala Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val 
    130                 135                 140                 


Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr 
145                 150                 155                 160 


Gly Pro Glu Glu Ser Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro 
                165                 170                 175     


Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro 
            180                 185                 190         


Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Ser Glu 
        195                 200                 205             


Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro 
    210                 215                 220                 


Pro Arg Glu Asp Leu Lys 
225                 230 


<210>  5
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  X = Gly, Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  X = Gly, Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  X = Gly, Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  X = Gly, Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (130)..(130)
<223>  X = Gly, Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (165)..(165)
<223>  X = Gly, Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (207)..(207)
<223>  X = Gly, Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (209)..(209)
<223>  X = Gly, Ala or Ser

<400>  5

Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Pro Thr Gly Ala Glu 
1               5                   10                  15      


Phe Leu Gly Asp Gly Gly Xaa Val Ser Phe Ser Thr Arg Gly Thr Gln 
            20                  25                  30          


Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu 
        35                  40                  45              


Xaa Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala 
    50                  55                  60                  


Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp 
65                  70                  75                  80  


Ala Ile Trp Xaa Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr 
                85                  90                  95      


Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Xaa Gly Arg Ile Arg Asn 
            100                 105                 110         


Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe 
        115                 120                 125             


Tyr Xaa Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val 
    130                 135                 140                 


Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr 
145                 150                 155                 160 


Gly Pro Glu Glu Xaa Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro 
                165                 170                 175     


Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro 
            180                 185                 190         


Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Xaa Glu 
        195                 200                 205             


Xaa Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro 
    210                 215                 220                 


Pro Arg Glu Asp Leu Lys 
225                 230 


<210>  6
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Pro Thr Gly Ala Glu 
1               5                   10                  15      


Phe Leu Gly Asp Gly Gly Ala Val Ser Phe Ser Thr Arg Gly Thr Gln 
            20                  25                  30          


Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu 
        35                  40                  45              


Gly Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala 
    50                  55                  60                  


Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp 
65                  70                  75                  80  


Ala Ile Trp Ala Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr 
                85                  90                  95      


Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Ala Gly Arg Ile Arg Asn 
            100                 105                 110         


Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe 
        115                 120                 125             


Tyr Ala Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val 
    130                 135                 140                 


Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr 
145                 150                 155                 160 


Gly Pro Glu Glu Ser Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro 
                165                 170                 175     


Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro 
            180                 185                 190         


Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Ser Glu 
        195                 200                 205             


Ala Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro 
    210                 215                 220                 


Pro Arg Glu Asp Leu Lys 
225                 230 


<210>  7
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Ala Pro Arg Arg Pro Leu 
                405                 410                 415     


Pro Gln Val Ala Thr Leu Ile Asp Arg Phe Val Lys Gly Arg Gly Gln 
            420                 425                 430         


Leu Asp Lys Asp Thr Leu Asp Thr Leu Thr Ala Phe Tyr Pro Gly Tyr 
        435                 440                 445             


Leu Cys Ser Leu Ser Pro Glu Glu Leu Ser Ser Val Pro Pro Ser Ser 
    450                 455                 460                 


Ile Trp Ala Val Arg Pro Gln Asp Leu Asp Thr Cys Asp Pro Arg Gln 
465                 470                 475                 480 


Leu Asp Val Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn Met Asn 
                485                 490                 495     


Gly Ser Glu Tyr Phe Val Lys Ile Gln Ser Phe Leu Gly Gly Ala Pro 
            500                 505                 510         


Thr Glu Asp Leu Lys Ala Leu Ser Gln Gln Asn Val Ser Met Asp Leu 
        515                 520                 525             


Ala Thr Phe Met Lys Leu Arg Thr Asp Ala Val Leu Pro Leu Thr Val 
    530                 535                 540                 


Ala Glu Val Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu Lys Ala 
545                 550                 555                 560 


Glu Glu Arg His Arg Pro Val Arg Asp Trp Ile Leu Arg Gln Arg Gln 
                565                 570                 575     


Asp Asp Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile Pro Asn 
            580                 585                 590         


Gly Tyr Leu Val Leu Asp Leu Ser Met Gln Glu Ala Leu Ser Gly Thr 
        595                 600                 605             


Pro Cys Leu Leu Gly Pro Gly Pro Val Leu Thr Val Leu Ala Leu Leu 
    610                 615                 620                 


Leu Ala Ser Thr Leu Ala 
625                 630 


<210>  8
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  8
caggagcagc tggaggagtc cgggggagac ctggtccagc ctgagggatc cctgacactc       60

acctgcaaag cctctgggtt agacttcagt agcagctact ggatatgttg ggtccgccag      120

gctccaggga aggggctgga gtggatcggg tgtcgtcata cttttactgc taacacatgg      180

tccgcgagct gggtgaatgg ccggttcacc atctccagaa gcaccagcct aggcacggtg      240

gatctgaaaa tgaccagtct gacagccgcg gacacggcca cctatttctg tgccagagat      300

gaatctaata atgatggttg ggattttaag ttgtggggcc caggcaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  9
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Gln Glu Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Lys Ala Ser Gly Leu Asp Phe Ser Ser Ser 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Arg His Thr Phe Thr Ala Asn Thr Trp Ser Ala Ser Trp 
    50                  55                  60                  


Val Asn Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Leu Gly Thr Val 
65                  70                  75                  80  


Asp Leu Lys Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Asp Glu Ser Asn Asn Asp Gly Trp Asp Phe Lys Leu Trp 
            100                 105                 110         


Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  10
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  10
gcctatgata tgacccagac tccagcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gagcattagt aactacttag cctggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctaccag gcatccactc tggcacctgg ggtctcatcg      180

cggttcaaag gcagtggatc tgggacagaa ttcactctca ccatcagcgg cgtggagtgt      240

gccgatgctg ccacttacta ctgtcaacag ggttatacta gtagtaatgt tgagaatgtt      300

ttcggcggag ggaccggggt ggtggtc                                          327


<210>  11
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Thr Leu Ala Pro Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Ser Ser Asn 
                85                  90                  95      


Val Glu Asn Val Phe Gly Gly Gly Thr Gly Val Val Val 
            100                 105                 


<210>  12
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  12
cagcagcagc tggaggagtc cgggggaggc ctggtcaagc ctgagggatc cctgacactc       60

acctgcaaag cctctggatt cgacctcggt ttctactttt acgcctgttg ggtccgccag      120

gctccaggga agggcctgga gtggatcgca tgcatttata ctgctggtag tggtagcacg      180

tactacgcga gctgggcgaa aggccgattc accatctcca aagcctcgtc gaccacggtg      240

actctgcaaa tgaccagtct ggcagccgcg gacacggcca cctatttctg tgcgagatct      300

actgctaata ctagaagtac ttattatctt aacttgtggg gcccaggcac cctggtcacc      360

gtctcctca                                                              369


<210>  13
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Gln Gln Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Asp Leu Gly Phe Tyr 
            20                  25                  30          


Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Tyr Thr Ala Gly Ser Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Ala Ser Ser Thr Thr Val 
65                  70                  75                  80  


Thr Leu Gln Met Thr Ser Leu Ala Ala Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser Thr Tyr Tyr Leu Asn Leu 
            100                 105                 110         


Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  14
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  14
gacgtcgtga tgacccagac tccagcctcc gtgtctgaac ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gaggattagt agttacttat cctggtatca gcagaaacca      120

gggcagcgtc ccaagctcct gatctttggt gcatccactc tggcatctgg ggtcccctcg      180

cggttcaaag gcagtggatc tgggacagaa tacactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcagagt tatgcttatt ttgatagtaa taattggcat      300

gctttcggcg gagggaccga ggtggtggtc                                       330


<210>  15
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser 
                85                  90                  95      


Asn Asn Trp His Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110 


<210>  16
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  16
caggagcagc tggtggagtc cgggggaggc ctggtccagc ctggggcatc cctgacactc       60

acctgcacag cctctggaat cgacttcagt cgctactaca tgtgttgggt ccgccaggct      120

ccagggaagg gactggaggg gatcgcatgt atttatattg gtggtagtgg tagcacttac      180

tacgcgagct gggcgaaagg ccgattcacc atctccaaag cctcgtcgac cacggtgact      240

ctgcaaatga ccagtctgac agccgcggac acggccactt atttctgtgc gagagggact      300

aatcttaatt atatttttag gttgtggggc ccaggcaccc tggtcaccgt ctcctca         357


<210>  17
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Ala 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Ile Asp Phe Ser Arg Tyr 
            20                  25                  30          


Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Ile 
        35                  40                  45              


Ala Cys Ile Tyr Ile Gly Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Ala Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Thr Asn Leu Asn Tyr Ile Phe Arg Leu Trp Gly Pro Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  18
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  18
gatgttgtga tgacccagac tccatctccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gagcattaat aatggtttag cctggtatca gcagaaacca      120

gggcagcctc ccaggctcct gatctattct gcatccaatc tggaatctgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcagcga cctggagtgt      240

gacgatgctg ccacttacta ttgtcaatgt atttgggatg gtaatagtta tgttaatgct      300

ttcggcggag ggaccgaggt ggtggtc                                          327


<210>  19
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Asp Val Val Met Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Asn Asn Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Ile Trp Asp Gly Asn Ser 
                85                  90                  95      


Tyr Val Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 


<210>  20
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  20
cagtcgttgg aggagtccgg gggagacctg gtcaagcctg gggcatccct gacactcacc       60

tgcaaagcct ctggattcga cttcagtagc aatgcaatgt gctgggtccg ccaggctcca      120

gggaaggggc tggagtggat cgcatgcatt tatgttggtg atggcaacac atactacgcg      180

agctgggcga aaggccgatt taccatctcc aaaacctcgt cgaccacggt gactctgcaa      240

atgaccagtc tgacagccgc ggacacggcc acctatttct gtgcgagggg atatgctagt      300

tatggtagtg attattattg ggactacttt aagttgtggg gccca                      345


<210>  21
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Asp Phe Ser Ser Asn Ala 
            20                  25                  30          


Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala 
        35                  40                  45              


Cys Ile Tyr Val Gly Asp Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu Gln 
65                  70                  75                  80  


Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


Gly Tyr Ala Ser Tyr Gly Ser Asp Tyr Tyr Trp Asp Tyr Phe Lys Leu 
            100                 105                 110         


Trp Gly Pro 
        115 


<210>  22
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  22
gcctatgata tgacccagac tccagcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gagcattagc actgcattag cctggtatca gcagaaacca      120

gggcagcctc ccaaggtcct gatctatgct gcatccaatc tggcatctgg ggtctcatcg      180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ttgtcaacag gctgctacca ttattaatgt tgataatgtt      300

ttcggcggag ggaccgaggt ggtggtc                                          327


<210>  23
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Thr Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ala Ala Thr Ile Ile Asn 
                85                  90                  95      


Val Asp Asn Val Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 


<210>  24
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  24
cagtcgttgg aggagtccgg gggagacctg gtcaagcctg gggcatccct gacactcacc       60

tgcacagcct ctggattctc cttcagtggc gactactaca tgtgctgggt ccgccaggct      120

ccagggaagg ggctggagtg gatcgcatgc attggtggtg gtagtaatac tgccacctac      180

tacgcgacct gggcgaaagg ccgattcacc atctccaaaa cctcgtcgac cacggtgact      240

ctgcaaatga ccagtctgac agccgcggac acggccacct atttctgtgc gagagatctc      300

ggttttgttg attatgcttt ggaattgtgg ggcccaggca ccctggtcac cgtctcctca      360


<210>  25
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Gly Asp Tyr 
            20                  25                  30          


Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Cys Ile Gly Gly Gly Ser Asn Thr Ala Thr Tyr Tyr Ala Thr Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Leu Gly Phe Val Asp Tyr Ala Leu Glu Leu Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  26
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  26
gacattgtga tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtga aaacatgtac aactctttag cctggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctacagg gcatccactc tggaatctgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggacagag tacactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaatgt actttttata gtcataataa taattatggt      300

ggtgctttcg gcggagggac cgaggtggtg gtc                                   333


<210>  27
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Asn Met Tyr Asn Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Phe Tyr Ser His Asn 
                85                  90                  95      


Asn Asn Tyr Gly Gly Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110     


<210>  28
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  28
caggagcagc tggaggagtc cgggggagac ctggtcaagc cgggggcatc cctgacactc       60

acctgcacag cctctggatt ctccttcagc agcagctact ggatatgctg ggtccgccag      120

gctccaggga aggggctgga gtggatcgca tgcatttatg ctggtgatgg tggtgccacc      180

tatgacgcga gctgggtgaa tggccgattc tccatctcca aaacctcgtc gaccacggtg      240

actctgcaaa tgaccagtct gacagccgcg gacacggcca cctatttctg tgcgagaaag      300

ggtgctgctc ctactactta ttactatttt aatttgtggg gcccaggcac cctggtcacc      360

gtctcctca                                                              369


<210>  29
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Gln Glu Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Tyr Ala Gly Asp Gly Gly Ala Thr Tyr Asp Ala Ser 
    50                  55                  60                  


Trp Val Asn Gly Arg Phe Ser Ile Ser Lys Thr Ser Ser Thr Thr Val 
65                  70                  75                  80  


Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Lys Gly Ala Ala Pro Thr Thr Tyr Tyr Tyr Phe Asn Leu 
            100                 105                 110         


Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  30
<211>  1806
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  30
atgcagcagc agctggagga gtccggggga ggcctggtca agcctgaggg atccctgaca       60

ctcacctgca aagcctctgg attcgacctc ggtttctact tttacgcctg ttgggtccgc      120

caggctccag ggaagggcct ggagtggatc gcatgcattt atactgctgg tagtggtagc      180

acgtactacg cgagctgggc gaaaggccga ttcaccatct ccaaagcctc gtcgaccacg      240

gtgactctgc aaatgaccag tctggcagcc gcggacacgg ccacctattt ctgtgcgaga      300

tctactgcta atactagaag tacttattat cttaacttgt ggggcccagg caccctggtc      360

accgtctcct caggcggagg cggatcaggt ggtggcggat ctggaggtgg cggaagcgac      420

gtcgtgatga cccagactcc agcctccgtg tctgaacctg tgggaggcac agtcaccatc      480

aagtgccagg ccagtcagag gattagtagt tacttatcct ggtatcagca gaaaccaggg      540

cagcgtccca agctcctgat ctttggtgca tccactctgg catctggggt cccctcgcgg      600

ttcaaaggca gtggatctgg gacagaatac actctcacca tcagcgacct ggagtgtgcc      660

gatgctgcca cttactactg tcagagttat gcttattttg atagtaataa ttggcatgct      720

ttcggcggag ggaccgaggt ggtggtcaaa gcttccggag gtcccgaggg cggcagcctg      780

gccgcgctga ccgcgcacca ggcttgccac ctgccgctgg agactttcac ccgtcatcgc      840

cagccgcgcg gctgggaaca actggagcag tgcggctatc cggtgcagcg gctggtcgcc      900

ctctacctgg cggcgcggct gtcgtggaac caggtcgacc aggtgatccg caacgccctg      960

gccagccccg gcagcggcgg cgacctgggc gaagcgatcc gcgagcagcc ggagcaggcc     1020

cgtctggccc tgaccctggc cgccgccgag agcgagcgct tcgtccggca gggcaccggc     1080

aacgacgagg ccggcgcggc caacggcccg gcggacagcg gcgacgccct gctggagcgc     1140

aactatccca ctggcgcgga gttcctcggc gacggcggcg acgtcagctt cagcacccgc     1200

ggcacgcaga actggacggt ggagcggctg ctccaggcgc accgccaact ggaggagcgc     1260

ggctatgtgt tcgtcggcta ccacggcacc ttcctcgaag cggcgcaaag catcgtcttc     1320

ggcggggtgc gcgcgcgcag ccaggacctc gacgcgatct ggcgcggttt ctatatcgcc     1380

ggcgatccgg cgctggccta cggctacgcc caggaccagg aacccgacgc acgcggccgg     1440

atccgcaacg gtgccctgct gcgggtctat gtgccgcgct cgagcctgcc gggcttctac     1500

cgcaccagcc tgaccctggc cgcgccggag gcggcgggcg aggtcgaacg gctgatcggc     1560

catccgctgc cgctgcgcct ggacgccatc accggccccg aggaggaagg cgggcgcctg     1620

gagaccattc tcggctggcc gctggccgag cgcaccgtgg tgattccctc ggcgatcccc     1680

accgacccgc gcaacgtcgg cggcgacctc gacccgtcca gcatccccga caaggaacag     1740

gcgatcagcg ccctgccgga ctacgccagc cagcccggca aaccgccgcg cgaggacctg     1800

aagtaa                                                                1806


<210>  31
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Met Gln Gln Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Glu 
1               5                   10                  15      


Gly Ser Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Asp Leu Gly Phe 
            20                  25                  30          


Tyr Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Ala Cys Ile Tyr Thr Ala Gly Ser Gly Ser Thr Tyr Tyr Ala 
    50                  55                  60                  


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Ala Ser Ser Thr Thr 
65                  70                  75                  80  


Val Thr Leu Gln Met Thr Ser Leu Ala Ala Ala Asp Thr Ala Thr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser Thr Tyr Tyr Leu Asn 
            100                 105                 110         


Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr 
    130                 135                 140                 


Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly Gly Thr Val Thr Ile 
145                 150                 155                 160 


Lys Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr Leu Ser Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile Phe Gly Ala Ser Thr 
            180                 185                 190         


Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser Asn Asn Trp His Ala 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Glu Val Val Val Lys Ala Ser Gly Gly Pro Glu 
                245                 250                 255     


Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro 
            260                 265                 270         


Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu 
        275                 280                 285             


Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala 
    290                 295                 300                 


Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu 
305                 310                 315                 320 


Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln 
                325                 330                 335     


Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu 
            340                 345                 350         


Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn 
        355                 360                 365             


Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr 
    370                 375                 380                 


Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg 
385                 390                 395                 400 


Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln 
                405                 410                 415     


Leu Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu 
            420                 425                 430         


Glu Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln 
        435                 440                 445             


Asp Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala 
    450                 455                 460                 


Leu Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg 
465                 470                 475                 480 


Ile Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu 
                485                 490                 495     


Pro Gly Phe Tyr Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala 
            500                 505                 510         


Gly Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp 
        515                 520                 525             


Ala Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu 
    530                 535                 540                 


Gly Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro 
545                 550                 555                 560 


Thr Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro 
                565                 570                 575     


Asp Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro 
            580                 585                 590         


Gly Lys Pro Pro Arg Glu Asp Leu Lys 
        595                 600     


<210>  32
<211>  1809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  32
atggaggtgc agctggtgga gtccggggga ggcctggtcc agcctggggg atccctgaga       60

ctctcctgcg cagcctctgg attcgacctc ggtttctact tttacgcctg ttgggtccgc      120

caggctccag ggaagggcct ggagtgggtc tcatgcattt atactgctgg tagtggtagc      180

acgtactacg cgagctgggc gaaaggccga ttcaccatct ccagagacaa ttcgaagaac      240

acgctgtatc tgcaaatgaa cagtctgaga gccgaggaca cggccgtgta ttactgtgcg      300

agatctactg ctaatactag aagtacttat tatcttaact tgtggggcca aggcaccctg      360

gtcaccgtct cctcaggcgg aggcggatca ggtggtggcg gatctggagg tggcggaagc      420

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc      480

atcacttgcc aggccagtca gaggattagt agttacttat cctggtatca gcagaaacca      540

gggaaagttc ccaagctcct gatctatggt gcatccactc tggcatctgg ggtcccctcg      600

cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      660

gaagatgttg ccacttacta ctgtcagagt tatgcttatt ttgatagtaa taattggcat      720

gctttcggcg gagggaccaa ggtggagatc aaagcttccg gaggtcccga gggcggcagc      780

ctggccgcgc tgaccgcgca ccaggcttgc cacctgccgc tggagacttt cacccgtcat      840

cgccagccgc gcggctggga acaactggag cagtgcggct atccggtgca gcggctggtc      900

gccctctacc tggcggcgcg gctgtcgtgg aaccaggtcg accaggtgat ccgcaacgcc      960

ctggccagcc ccggcagcgg cggcgacctg ggcgaagcga tccgcgagca gccggagcag     1020

gcccgtctgg ccctgaccct ggccgccgcc gagagcgagc gcttcgtccg gcagggcacc     1080

ggcaacgacg aggccggcgc ggccaacggc ccggcggaca gcggcgacgc cctgctggag     1140

cgcaactatc ccactggcgc ggagttcctc ggcgacggcg gcgacgtcag cttcagcacc     1200

cgcggcacgc agaactggac ggtggagcgg ctgctccagg cgcaccgcca actggaggag     1260

cgcggctatg tgttcgtcgg ctaccacggc accttcctcg aagcggcgca aagcatcgtc     1320

ttcggcgggg tgcgcgcgcg cagccaggac ctcgacgcga tctggcgcgg tttctatatc     1380

gccggcgatc cggcgctggc ctacggctac gcccaggacc aggaacccga cgcacgcggc     1440

cggatccgca acggtgccct gctgcgggtc tatgtgccgc gctcgagcct gccgggcttc     1500

taccgcacca gcctgaccct ggccgcgccg gaggcggcgg gcgaggtcga acggctgatc     1560

ggccatccgc tgccgctgcg cctggacgcc atcaccggcc ccgaggagga aggcgggcgc     1620

ctggagacca ttctcggctg gccgctggcc gagcgcaccg tggtgattcc ctcggcgatc     1680

cccaccgacc cgcgcaacgt cggcggcgac ctcgacccgt ccagcatccc cgacaaggaa     1740

caggcgatca gcgccctgcc ggactacgcc agccagcccg gcaaaccgcc gcgcgaggac     1800

ctgaagtaa                                                             1809


<210>  33
<211>  602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Leu Gly Phe 
            20                  25                  30          


Tyr Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Cys Ile Tyr Thr Ala Gly Ser Gly Ser Thr Tyr Tyr Ala 
    50                  55                  60                  


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
65                  70                  75                  80  


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser Thr Tyr Tyr Leu 
            100                 105                 110         


Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr Leu Ser Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr Gly Ala Ser 
            180                 185                 190         


Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser Asn Asn Trp His 
225                 230                 235                 240 


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ala Ser Gly Gly Pro 
                245                 250                 255     


Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu 
            260                 265                 270         


Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln 
        275                 280                 285             


Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu 
    290                 295                 300                 


Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala 
305                 310                 315                 320 


Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu 
                325                 330                 335     


Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser 
            340                 345                 350         


Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala 
        355                 360                 365             


Asn Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro 
    370                 375                 380                 


Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr 
385                 390                 395                 400 


Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg 
                405                 410                 415     


Gln Leu Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe 
            420                 425                 430         


Leu Glu Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser 
        435                 440                 445             


Gln Asp Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro 
    450                 455                 460                 


Ala Leu Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly 
465                 470                 475                 480 


Arg Ile Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser 
                485                 490                 495     


Leu Pro Gly Phe Tyr Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala 
            500                 505                 510         


Ala Gly Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu 
        515                 520                 525             


Asp Ala Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile 
    530                 535                 540                 


Leu Gly Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile 
545                 550                 555                 560 


Pro Thr Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile 
                565                 570                 575     


Pro Asp Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln 
            580                 585                 590         


Pro Gly Lys Pro Pro Arg Glu Asp Leu Lys 
        595                 600         


<210>  34
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  34
atgcaggagc agctggagga gtccggggga gacctggtcc agcctgaggg atccctgaca       60

ctcacctgca aagcctctgg gttagacttc agtagcagct actggatatg ttgggtccgc      120

caggctccag ggaaggggct ggagtggatc gggtgtcgtc atacttttac tgctaacaca      180

tggtccgcga gctgggtgaa tggccggttc accatctcca gaagcaccag cctaggcacg      240

gtggatctga aaatgaccag tctgacagcc gcggacacgg ccacctattt ctgtgccaga      300

gatgaatcta ataatgatgg ttgggatttt aagttgtggg gcccaggcac cctggtcacc      360

gtctcctcag gcggaggcgg atcaggtggt ggcggatctg gaggtggcgg aagcgcctat      420

gatatgaccc agactccagc ctccgtgtct gcagctgtgg gaggcacagt caccatcaag      480

tgccaggcca gtcagagcat tagtaactac ttagcctggt atcagcagaa accagggcag      540

cctcccaagc tcctgatcta ccaggcatcc actctggcac ctggggtctc atcgcggttc      600

aaaggcagtg gatctgggac agaattcact ctcaccatca gcggcgtgga gtgtgccgat      660

gctgccactt actactgtca acagggttat actagtagta atgttgagaa tgttttcggc      720

ggagggaccg gggtggtggt caaagcttcc ggaggtcccg agggcggcag cctggccgcg      780

ctgaccgcgc accaggcttg ccacctgccg ctggagactt tcacccgtca tcgccagccg      840

cgcggctggg aacaactgga gcagtgcggc tatccggtgc agcggctggt cgccctctac      900

ctggcggcgc ggctgtcgtg gaaccaggtc gaccaggtga tccgcaacgc cctggccagc      960

cccggcagcg gcggcgacct gggcgaagcg atccgcgagc agccggagca ggcccgtctg     1020

gccctgaccc tggccgccgc cgagagcgag cgcttcgtcc ggcagggcac cggcaacgac     1080

gaggccggcg cggccaacgg cccggcggac agcggcgacg ccctgctgga gcgcaactat     1140

cccactggcg cggagttcct cggcgacggc ggcgacgtca gcttcagcac ccgcggcacg     1200

cagaactgga cggtggagcg gctgctccag gcgcaccgcc aactggagga gcgcggctat     1260

gtgttcgtcg gctaccacgg caccttcctc gaagcggcgc aaagcatcgt cttcggcggg     1320

gtgcgcgcgc gcagccagga cctcgacgcg atctggcgcg gtttctatat cgccggcgat     1380

ccggcgctgg cctacggcta cgcccaggac caggaacccg acgcacgcgg ccggatccgc     1440

aacggtgccc tgctgcgggt ctatgtgccg cgctcgagcc tgccgggctt ctaccgcacc     1500

agcctgaccc tggccgcgcc ggaggcggcg ggcgaggtcg aacggctgat cggccatccg     1560

ctgccgctgc gcctggacgc catcaccggc cccgaggagg aaggcgggcg cctggagacc     1620

attctcggct ggccgctggc cgagcgcacc gtggtgattc cctcggcgat ccccaccgac     1680

ccgcgcaacg tcggcggcga cctcgacccg tccagcatcc ccgacaagga acaggcgatc     1740

agcgccctgc cggactacgc cagccagccc ggcaaaccgc cgcgcgagga cctgaagtaa     1800


<210>  35
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Met Gln Glu Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Gln Pro Glu 
1               5                   10                  15      


Gly Ser Leu Thr Leu Thr Cys Lys Ala Ser Gly Leu Asp Phe Ser Ser 
            20                  25                  30          


Ser Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Cys Arg His Thr Phe Thr Ala Asn Thr Trp Ser Ala Ser 
    50                  55                  60                  


Trp Val Asn Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Leu Gly Thr 
65                  70                  75                  80  


Val Asp Leu Lys Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Asp Glu Ser Asn Asn Asp Gly Trp Asp Phe Lys Leu 
            100                 105                 110         


Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Tyr Asp Met Thr Gln 
    130                 135                 140                 


Thr Pro Ala Ser Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Lys 
145                 150                 155                 160 


Cys Gln Ala Ser Gln Ser Ile Ser Asn Tyr Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Gln Ala Ser Thr Leu 
            180                 185                 190         


Ala Pro Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Gly Val Glu Cys Ala Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Gly Tyr Thr Ser Ser Asn Val Glu Asn Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Gly Val Val Val Lys Ala Ser Gly Gly Pro Glu Gly Gly 
                245                 250                 255     


Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu 
            260                 265                 270         


Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln 
        275                 280                 285             


Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg 
    290                 295                 300                 


Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser 
305                 310                 315                 320 


Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu 
                325                 330                 335     


Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe 
            340                 345                 350         


Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn Gly Pro 
        355                 360                 365             


Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala 
    370                 375                 380                 


Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr 
385                 390                 395                 400 


Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu 
                405                 410                 415     


Glu Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala 
            420                 425                 430         


Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu 
        435                 440                 445             


Asp Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala 
    450                 455                 460                 


Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg 
465                 470                 475                 480 


Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly 
                485                 490                 495     


Phe Tyr Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu 
            500                 505                 510         


Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile 
        515                 520                 525             


Thr Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp 
    530                 535                 540                 


Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp 
545                 550                 555                 560 


Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys 
                565                 570                 575     


Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys 
            580                 585                 590         


Pro Pro Arg Glu Asp Leu Lys 
        595                 


<210>  36
<211>  1791
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  36
atgcaggagc agctggtgga gtccggggga ggcctggtcc agcctggggc atccctgaca       60

ctcacctgca cagcctctgg aatcgacttc agtcgctact acatgtgttg ggtccgccag      120

gctccaggga agggactgga ggggatcgca tgtatttata ttggtggtag tggtagcact      180

tactacgcga gctgggcgaa aggccgattc accatctcca aagcctcgtc gaccacggtg      240

actctgcaaa tgaccagtct gacagccgcg gacacggcca cttatttctg tgcgagaggg      300

actaatctta attatatttt taggttgtgg ggcccaggca ccctggtcac cgtctcctca      360

ggcggaggcg gatcaggtgg tggcggatct ggaggtggcg gaagcgatgt tgtgatgacc      420

cagactccat ctcccgtgtc tgcagctgtg ggaggcacag tcaccatcaa gtgccaggcc      480

agtcagagca ttaataatgg tttagcctgg tatcagcaga aaccagggca gcctcccagg      540

ctcctgatct attctgcatc caatctggaa tctggggtcc catcgcggtt caaaggcagt      600

ggatctggga cagagttcac tctcaccatc agcgacctgg agtgtgacga tgctgccact      660

tactattgtc aatgtatttg ggatggtaat agttatgtta atgctttcgg cggagggacc      720

gaggtggtgg tcaaagcttc cggaggtccc gagggcggca gcctggccgc gctgaccgcg      780

caccaggctt gccacctgcc gctggagact ttcacccgtc atcgccagcc gcgcggctgg      840

gaacaactgg agcagtgcgg ctatccggtg cagcggctgg tcgccctcta cctggcggcg      900

cggctgtcgt ggaaccaggt cgaccaggtg atccgcaacg ccctggccag ccccggcagc      960

ggcggcgacc tgggcgaagc gatccgcgag cagccggagc aggcccgtct ggccctgacc     1020

ctggccgccg ccgagagcga gcgcttcgtc cggcagggca ccggcaacga cgaggccggc     1080

gcggccaacg gcccggcgga cagcggcgac gccctgctgg agcgcaacta tcccactggc     1140

gcggagttcc tcggcgacgg cggcgacgtc agcttcagca cccgcggcac gcagaactgg     1200

acggtggagc ggctgctcca ggcgcaccgc caactggagg agcgcggcta tgtgttcgtc     1260

ggctaccacg gcaccttcct cgaagcggcg caaagcatcg tcttcggcgg ggtgcgcgcg     1320

cgcagccagg acctcgacgc gatctggcgc ggtttctata tcgccggcga tccggcgctg     1380

gcctacggct acgcccagga ccaggaaccc gacgcacgcg gccggatccg caacggtgcc     1440

ctgctgcggg tctatgtgcc gcgctcgagc ctgccgggct tctaccgcac cagcctgacc     1500

ctggccgcgc cggaggcggc gggcgaggtc gaacggctga tcggccatcc gctgccgctg     1560

cgcctggacg ccatcaccgg ccccgaggag gaaggcgggc gcctggagac cattctcggc     1620

tggccgctgg ccgagcgcac cgtggtgatt ccctcggcga tccccaccga cccgcgcaac     1680

gtcggcggcg acctcgaccc gtccagcatc cccgacaagg aacaggcgat cagcgccctg     1740

ccggactacg ccagccagcc cggcaaaccg ccgcgcgagg acctgaagta a              1791


<210>  37
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Met Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Ala Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Ile Asp Phe Ser Arg 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly 
        35                  40                  45              


Ile Ala Cys Ile Tyr Ile Gly Gly Ser Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Ala Ser Ser Thr Thr Val 
65                  70                  75                  80  


Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Gly Thr Asn Leu Asn Tyr Ile Phe Arg Leu Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Ser 
    130                 135                 140                 


Pro Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Asn Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Pro Pro Arg Leu Leu Ile Tyr Ser Ala Ser Asn Leu Glu Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Cys Ile Trp Asp Gly Asn Ser Tyr Val Asn Ala Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Glu Val Val Val Lys Ala Ser Gly Gly Pro Glu Gly Gly Ser Leu Ala 
                245                 250                 255     


Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe Thr 
            260                 265                 270         


Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr 
        275                 280                 285             


Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp 
    290                 295                 300                 


Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly Ser 
305                 310                 315                 320 


Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala Arg 
                325                 330                 335     


Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg Gln 
            340                 345                 350         


Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn Gly Pro Ala Asp Ser 
        355                 360                 365             


Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe Leu 
    370                 375                 380                 


Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp 
385                 390                 395                 400 


Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu Arg Gly 
                405                 410                 415     


Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln Ser 
            420                 425                 430         


Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala Ile 
        435                 440                 445             


Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly Tyr 
    450                 455                 460                 


Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly Ala 
465                 470                 475                 480 


Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr Arg 
                485                 490                 495     


Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu Arg 
            500                 505                 510         


Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly Pro 
        515                 520                 525             


Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu Ala 
    530                 535                 540                 


Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg Asn 
545                 550                 555                 560 


Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln Ala 
                565                 570                 575     


Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro Arg 
            580                 585                 590         


Glu Asp Leu Lys 
        595     


<210>  38
<211>  1803
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  38
atgcaggagc agctggagga gtccggggga gacctggtca agccgggggc atccctgaca       60

ctcacctgca cagcctctgg attctccttc agcagcagct actggatatg ctgggtccgc      120

caggctccag ggaaggggct ggagtggatc gcatgcattt atgctggtga tggtggtgcc      180

acctatgacg cgagctgggt gaatggccga ttctccatct ccaaaacctc gtcgaccacg      240

gtgactctgc aaatgaccag tctgacagcc gcggacacgg ccacctattt ctgtgcgaga      300

aagggtgctg ctcctactac ttattactat tttaatttgt ggggcccagg caccctggtc      360

accgtctcct caggcggagg cggatcaggt ggtggcggat ctggaggtgg cggaagcgcc      420

tatgatatga cccagactcc agcctccgtg tctgcagctg tgggaggcac agtcaccatc      480

aagtgccagg ccagtcagag cattagcact gcattagcct ggtatcagca gaaaccaggg      540

cagcctccca aggtcctgat ctatgctgca tccaatctgg catctggggt ctcatcgcgg      600

ttcaaaggca gtggatctgg gacagagttc actctcacca tcagcgacct ggagtgtgcc      660

gatgctgcca cttactattg tcaacaggct gctaccatta ttaatgttga taatgttttc      720

ggcggaggga ccgaggtggt ggtcaaagct tccggaggtc ccgagggcgg cagcctggcc      780

gcgctgaccg cgcaccaggc ttgccacctg ccgctggaga ctttcacccg tcatcgccag      840

ccgcgcggct gggaacaact ggagcagtgc ggctatccgg tgcagcggct ggtcgccctc      900

tacctggcgg cgcggctgtc gtggaaccag gtcgaccagg tgatccgcaa cgccctggcc      960

agccccggca gcggcggcga cctgggcgaa gcgatccgcg agcagccgga gcaggcccgt     1020

ctggccctga ccctggccgc cgccgagagc gagcgcttcg tccggcaggg caccggcaac     1080

gacgaggccg gcgcggccaa cggcccggcg gacagcggcg acgccctgct ggagcgcaac     1140

tatcccactg gcgcggagtt cctcggcgac ggcggcgacg tcagcttcag cacccgcggc     1200

acgcagaact ggacggtgga gcggctgctc caggcgcacc gccaactgga ggagcgcggc     1260

tatgtgttcg tcggctacca cggcaccttc ctcgaagcgg cgcaaagcat cgtcttcggc     1320

ggggtgcgcg cgcgcagcca ggacctcgac gcgatctggc gcggtttcta tatcgccggc     1380

gatccggcgc tggcctacgg ctacgcccag gaccaggaac ccgacgcacg cggccggatc     1440

cgcaacggtg ccctgctgcg ggtctatgtg ccgcgctcga gcctgccggg cttctaccgc     1500

accagcctga ccctggccgc gccggaggcg gcgggcgagg tcgaacggct gatcggccat     1560

ccgctgccgc tgcgcctgga cgccatcacc ggccccgagg aggaaggcgg gcgcctggag     1620

accattctcg gctggccgct ggccgagcgc accgtggtga ttccctcggc gatccccacc     1680

gacccgcgca acgtcggcgg cgacctcgac ccgtccagca tccccgacaa ggaacaggcg     1740

atcagcgccc tgccggacta cgccagccag cccggcaaac cgccgcgcga ggacctgaag     1800

taa                                                                   1803


<210>  39
<211>  600
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  39

Met Gln Glu Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser 
            20                  25                  30          


Ser Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Ala Cys Ile Tyr Ala Gly Asp Gly Gly Ala Thr Tyr Asp Ala 
    50                  55                  60                  


Ser Trp Val Asn Gly Arg Phe Ser Ile Ser Lys Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Val Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Lys Gly Ala Ala Pro Thr Thr Tyr Tyr Tyr Phe Asn 
            100                 105                 110         


Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Tyr Asp Met Thr 
    130                 135                 140                 


Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile 
145                 150                 155                 160 


Lys Cys Gln Ala Ser Gln Ser Ile Ser Thr Ala Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Pro Pro Lys Val Leu Ile Tyr Ala Ala Ser Asn 
            180                 185                 190         


Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ala Ala Thr Ile Ile Asn Val Asp Asn Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Glu Val Val Val Lys Ala Ser Gly Gly Pro Glu Gly 
                245                 250                 255     


Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu 
            260                 265                 270         


Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu 
        275                 280                 285             


Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala 
    290                 295                 300                 


Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala 
305                 310                 315                 320 


Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro 
                325                 330                 335     


Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg 
            340                 345                 350         


Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn Gly 
        355                 360                 365             


Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly 
    370                 375                 380                 


Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly 
385                 390                 395                 400 


Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu 
                405                 410                 415     


Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu 
            420                 425                 430         


Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp 
        435                 440                 445             


Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu 
    450                 455                 460                 


Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile 
465                 470                 475                 480 


Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro 
                485                 490                 495     


Gly Phe Tyr Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly 
            500                 505                 510         


Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala 
        515                 520                 525             


Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly 
    530                 535                 540                 


Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr 
545                 550                 555                 560 


Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp 
                565                 570                 575     


Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly 
            580                 585                 590         


Lys Pro Pro Arg Glu Asp Leu Lys 
        595                 600 


