                         SEQUENCE LISTING

<110>  TransAlage Israel Ltd.
 
<120>  TRANSGENIC MICROALGAE AND USE THEREOF FOR ORAL DELIVERY OF 
       PROTEINS

<130>  TRAG/005 PCT

<150>  61/692240
<151>  2012-08-23

<150>  61/781103
<151>  2013-03-14

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  567
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide (Salmon growth hormone in Phaeodactylum 
       tricornutum codon usage)

<400>  1
atgattgaaa accagcgttt gttcaacatt gccgtctccc gtgtccagca cctccacctc       60

ttggcccaga agatgttcaa cgacttcgac ggaaccctcc tccccgacga acgtcgtcag      120

ctcaacaaga ttttcctcct cgacttctgc aactccgact ccattgtctc ccccgtcgac      180

aagcacgaaa cccagaagtc ctccgtcctc aagctcctcc acatttcctt ccgcctcatc      240

gaatcctggg aatacccctc ccagaccctc attatttcca actccctcat ggtccgcaac      300

gccaaccaga tttccgaaaa gctctccgat ctcaaggtcg gaatcaacct cctcattacc      360

ggttcccagg acggactcct ctccctcgac gacaacgact cccagcagct ccccccctac      420

ggaaactact accagaacct cggaggcgac ggaaacgtcc gtcgtaacta cgaactcctc      480

gcctgcttca agaaggacat gcacaaggtc gaaacctacc tcaccgtcgc caagtgccgc      540

aagtccctcg aagccaactg caccctc                                          567


<210>  2
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide (Phaeodactylum tricornutum Endoplasmic 
       reticulum Leader Sequence)

<400>  2

Met Met Phe Met Arg Ile Ala Val Ala Ala Leu Ala Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ser Ile Arg Ala Glu Glu Ala Gly Glu Glu Ala Lys Met Gly Thr 
            20                  25                  30          


Val 
    


<210>  3
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Met Met Phe Met Arg Ile Ala Val Ala Ala Leu Ala Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ser Ile Arg Ala Glu Glu Ala Gly Glu Glu Ala Lys Met Gly Thr 
            20                  25                  30          


Val Ile Glu Asn Gln Arg Leu Phe Asn Ile Ala Val Ser Arg Val Gln 
        35                  40                  45              


His Leu His Leu Leu Ala Gln Lys Met Phe Asn Asp Phe Asp Gly Thr 
    50                  55                  60                  


Leu Leu Pro Asp Glu Arg Arg Gln Leu Asn Lys Ile Phe Leu Leu Asp 
65                  70                  75                  80  


Phe Cys Asn Ser Asp Ser Ile Val Ser Pro Val Asp Lys His Glu Thr 
                85                  90                  95      


Gln Lys Ser Ser Val Leu Lys Leu Leu His Ile Ser Phe Arg Leu Ile 
            100                 105                 110         


Glu Ser Trp Glu Tyr Pro Ser Gln Thr Leu Ile Ile Ser Asn Ser Leu 
        115                 120                 125             


Met Val Arg Asn Ala Asn Gln Ile Ser Glu Lys Leu Ser Asp Leu Lys 
    130                 135                 140                 


Val Gly Ile Asn Leu Leu Ile Thr Gly Ser Gln Asp Gly Leu Leu Ser 
145                 150                 155                 160 


Leu Asp Asp Asn Asp Ser Gln Gln Leu Pro Pro Tyr Gly Asn Tyr Tyr 
                165                 170                 175     


Gln Asn Leu Gly Gly Asp Gly Asn Val Arg Arg Asn Tyr Glu Leu Leu 
            180                 185                 190         


Ala Cys Phe Lys Lys Asp Met His Lys Val Glu Thr Tyr Leu Thr Val 
        195                 200                 205             


Ala Lys Cys Arg Lys Ser Leu Glu Ala Asn Cys Thr Leu 
    210                 215                 220     


<210>  4
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide (Phaeodactylum tricornutum Short Vacuole Leader
       Sequence)

<400>  4

Met Ser Ile Arg Leu Phe Ser Thr Ala Leu Leu Ala Ala Cys Leu Ala 
1               5                   10                  15      


Lys Ala Thr Ala Gln Thr 
            20          


<210>  5
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  5

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Tyr Pro Tyr Asp Val Pro 
1               5                   10                  15      


Asp Tyr Ala Gly Ser Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Gln 
            20                  25                  30          


<210>  6
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Met Ser Ile Arg Leu Phe Ser Thr Ala Leu Leu Ala Ala Cys Leu Ala 
1               5                   10                  15      


Lys Ala Thr Ala Gln Thr Gly Ser Ile Glu Asn Gln Arg Leu Phe Asn 
            20                  25                  30          


Ile Ala Val Ser Arg Val Gln His Leu His Leu Leu Ala Gln Lys Met 
        35                  40                  45              


Phe Asn Asp Phe Asp Gly Thr Leu Leu Pro Asp Glu Arg Arg Gln Leu 
    50                  55                  60                  


Asn Lys Ile Phe Leu Leu Asp Phe Cys Asn Ser Asp Ser Ile Val Ser 
65                  70                  75                  80  


Pro Val Asp Lys His Glu Thr Gln Lys Ser Ser Val Leu Lys Leu Leu 
                85                  90                  95      


His Ile Ser Phe Arg Leu Ile Glu Ser Trp Glu Tyr Pro Ser Gln Thr 
            100                 105                 110         


Leu Ile Ile Ser Asn Ser Leu Met Val Arg Asn Ala Asn Gln Ile Ser 
        115                 120                 125             


Glu Lys Leu Ser Asp Leu Lys Val Gly Ile Asn Leu Leu Ile Thr Gly 
    130                 135                 140                 


Ser Gln Asp Gly Leu Leu Ser Leu Asp Asp Asn Asp Ser Gln Gln Leu 
145                 150                 155                 160 


Pro Pro Tyr Gly Asn Tyr Tyr Gln Asn Leu Gly Gly Asp Gly Asn Val 
                165                 170                 175     


Arg Arg Asn Tyr Glu Leu Leu Ala Cys Phe Lys Lys Asp Met His Lys 
            180                 185                 190         


Val Glu Thr Tyr Leu Thr Val Ala Lys Cys Arg Lys Ser Leu Glu Ala 
        195                 200                 205             


Asn Cys Thr Leu Arg Ser Gly Gly Gly Gly Gly Tyr Pro Tyr Asp Val 
    210                 215                 220                 


Pro Asp Tyr Ala Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Ser 
225                 230                 235                 240 


Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Gln 
                245                 250     


<210>  7
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  7

Ala Ala Val Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10          


<210>  8
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Met Ser Ile Arg Leu Phe Ser Thr Ala Leu Leu Ala Ala Cys Leu Ala 
1               5                   10                  15      


Lys Ala Thr Ala Gln Thr Gly Ser Ile Glu Asn Gln Arg Leu Phe Asn 
            20                  25                  30          


Ile Ala Val Ser Arg Val Gln His Leu His Leu Leu Ala Gln Lys Met 
        35                  40                  45              


Phe Asn Asp Phe Asp Gly Thr Leu Leu Pro Asp Glu Arg Arg Gln Leu 
    50                  55                  60                  


Asn Lys Ile Phe Leu Leu Asp Phe Cys Asn Ser Asp Ser Ile Val Ser 
65                  70                  75                  80  


Pro Val Asp Lys His Glu Thr Gln Lys Ser Ser Val Leu Lys Leu Leu 
                85                  90                  95      


His Ile Ser Phe Arg Leu Ile Glu Ser Trp Glu Tyr Pro Ser Gln Thr 
            100                 105                 110         


Leu Ile Ile Ser Asn Ser Leu Met Val Arg Asn Ala Asn Gln Ile Ser 
        115                 120                 125             


Glu Lys Leu Ser Asp Leu Lys Val Gly Ile Asn Leu Leu Ile Thr Gly 
    130                 135                 140                 


Ser Gln Asp Gly Leu Leu Ser Leu Asp Asp Asn Asp Ser Gln Gln Leu 
145                 150                 155                 160 


Pro Pro Tyr Gly Asn Tyr Tyr Gln Asn Leu Gly Gly Asp Gly Asn Val 
                165                 170                 175     


Arg Arg Asn Tyr Glu Leu Leu Ala Cys Phe Lys Lys Asp Met His Lys 
            180                 185                 190         


Val Glu Thr Tyr Leu Thr Val Ala Lys Cys Arg Lys Ser Leu Glu Ala 
        195                 200                 205             


Asn Cys Thr Leu Arg Ser Ala Ala Val Leu Leu Pro Val Leu Leu Ala 
    210                 215                 220                 


Ala Pro Arg Ser Gly Gly Gly Gly Gly Tyr Pro Tyr Asp Val Pro Asp 
225                 230                 235                 240 


Tyr Ala Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Ser Tyr Pro 
                245                 250                 255     


Tyr Asp Val Pro Asp Tyr Ala Ala Gln 
            260                 265 


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  9

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  10
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

Met Ser Ile Arg Leu Phe Ser Thr Ala Leu Leu Ala Ala Cys Leu Ala 
1               5                   10                  15      


Lys Ala Thr Ala Gln Thr Gly Ser Ile Glu Asn Gln Arg Leu Phe Asn 
            20                  25                  30          


Ile Ala Val Ser Arg Val Gln His Leu His Leu Leu Ala Gln Lys Met 
        35                  40                  45              


Phe Asn Asp Phe Asp Gly Thr Leu Leu Pro Asp Glu Arg Arg Gln Leu 
    50                  55                  60                  


Asn Lys Ile Phe Leu Leu Asp Phe Cys Asn Ser Asp Ser Ile Val Ser 
65                  70                  75                  80  


Pro Val Asp Lys His Glu Thr Gln Lys Ser Ser Val Leu Lys Leu Leu 
                85                  90                  95      


His Ile Ser Phe Arg Leu Ile Glu Ser Trp Glu Tyr Pro Ser Gln Thr 
            100                 105                 110         


Leu Ile Ile Ser Asn Ser Leu Met Val Arg Asn Ala Asn Gln Ile Ser 
        115                 120                 125             


Glu Lys Leu Ser Asp Leu Lys Val Gly Ile Asn Leu Leu Ile Thr Gly 
    130                 135                 140                 


Ser Gln Asp Gly Leu Leu Ser Leu Asp Asp Asn Asp Ser Gln Gln Leu 
145                 150                 155                 160 


Pro Pro Tyr Gly Asn Tyr Tyr Gln Asn Leu Gly Gly Asp Gly Asn Val 
                165                 170                 175     


Arg Arg Asn Tyr Glu Leu Leu Ala Cys Phe Lys Lys Asp Met His Lys 
            180                 185                 190         


Val Glu Thr Tyr Leu Thr Val Ala Lys Cys Arg Lys Ser Leu Glu Ala 
        195                 200                 205             


Asn Cys Thr Leu Arg Ser Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg 
    210                 215                 220                 


Arg Arg Ser Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Arg Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Tyr 
                245                 250                 255     


Pro Tyr Asp Val Pro Asp Tyr Ala Gly Ser Tyr Pro Tyr Asp Val Pro 
            260                 265                 270         


Asp Tyr Ala Ala Gln 
        275         


<210>  11
<211>  4095
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide (pPhaT1 algae expression vector)

<400>  11
gggctgcagg acgcaatgga ggattatcac cgcaaaaatg aacttcgaaa aaaactttcg       60

agcgaccatg gaaaaggagg atcagattca gattacaaca gtggattgct ctggtagcaa      120

atatcttctg ctagattggc tcatggtcgg ttttggacgt tcgaagctca ccgtcaaaag      180

aaacaaaaga gaagaatgac gtcttcgtga cgtagaatct acgactgtac tcggatctgg      240

gaaatgaatt gactcacggt cttcttcgag tcctgttaca ggcccttggt ccgaaccccc      300

acacgatttt tgcaccaaag atttgcttca atttgctgga tgttttgact gcaagatcag      360

ctggcctagc aagagtgctc gtgttgcttc gtcgggaatc cctacgaatt tcagttctgc      420

acaaatttgt ctgccgtttc gagaattcga tatcatcgac taattcgagc tcggtacccg      480

gggatcctct agagtcgacc tgcaggcatg caagcttcag aagcgtgcta tcgaactcaa      540

ccagggacgt gcggcacaaa tgggcatcct tgctctcatg gtgcacgaac agttgggagt      600

ctctatcctt ccttaaaaat ttaattttca ttagttgcag tcactccgct ttggtttcac      660

agtcaggaat aacactagct cgtcttcacc atggatgcca atctcgccta ttcatggtgt      720

ataaaagttc aacatccaaa gctagaactt ttggaaagag aaagaatatc cgaatagggc      780

acggcgtgcc gtattgttgg agtggactag cagaaagtga ggaaggcaca ggatgagttt      840

tctcgagaca taccttcagc gtcgtcttca ctgtcacagt caactgacag taatcgttga      900

tccggagaga ttcaaaattc aatctgtttg gacctggata agacacaaga gcgacatcct      960

gacatgaacg ccgtaaacag caaatcctgg ttgaacacgt atccttttgg gggcctccgc     1020

tacgacgctc gctccagctg gggcttcctt actatacaca gcgcgcatat ttcacggttg     1080

ccagatgtca agatggccaa gttgaccagt gccgttccgg tgctcaccgc gcgcgacgtc     1140

gccggagcgg tcgagttctg gaccgaccgg ctcgggttct cccgggactt cgtggaggac     1200

gacttcgccg gtgtggtccg ggacgacgtg accctgttca tcagcgcggt ccaggaccag     1260

gtggtgccgg acaacaccct ggcctgggtg tgggtgcgcg gcctggacga gctgtacgcc     1320

gagtggtcgg aggtcgtgtc cacgaacttc cgggacgcct ccgggccggc catgaccgag     1380

atcggcgagc agccgtgggg gcgggagttc gccctgcgcg acccggccgg caactgcgtg     1440

cacttcgtgg ccgaggagca ggactgaacc ttccttaaaa atttaatttt cattagttgc     1500

agtcactccg ctttggtttc acagtcagga ataacactag ctcgtcttca ccatggatgc     1560

caatctcgcc tattcatggt gtataaaagt tcaacatcca aagctagaac ttttggaaag     1620

agaaagaata tccgaatagg gcacggcgtg ccgtattgtt ggagtggact agcagaaagt     1680

gaggaaggca caggatgagt tttctcgagg ccggtctccc tatagtgagt cgtattaatt     1740

tcgataagcc aggttaacct gcattaatga atcggccaac gcgcggggag aggcggtttg     1800

cgtattgggc gctcttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg     1860

cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat     1920

aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc     1980

gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc     2040

tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga     2100

agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt     2160

ctcccttcgg gaagcgtggc gctttctcaa tgctcacgct gtaggtatct cagttcggtg     2220

taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc     2280

gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg     2340

gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc     2400

ttgaagtggt ggcctaacta cggctacact agaaggacag tatttggtat ctgcgctctg     2460

ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc     2520

gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct     2580

caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt     2640

taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa     2700

aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa     2760

tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc     2820

tgactccccg tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct     2880

gcaatgatac cgcgagaccc acgctcaccg gctccagatt tatcagcaat aaaccagcca     2940

gccggaaggg ccgagcgcag aagtggtcct gcaactttat ccgcctccat ccagtctatt     3000

aattgttgcc gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt     3060

gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc     3120

ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc     3180

tccttcggtc ctccgatcgt tgtcagaagt aagttggccg cagtgttatc actcatggtt     3240

atggcagcac tgcataattc tcttactgtc atgccatccg taagatgctt ttctgtgact     3300

ggtgagtact caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc     3360

ccggcgtcaa tacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt     3420

ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg     3480

atgtaaccca ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct     3540

gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa     3600

tgttgaatac tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt     3660

ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc     3720

acatttcccc gaaaagtgcc acctgacgtc taagaaacca ttattatcat gacattaacc     3780

tataaaaata ggcgtatcac gaggcccttt cgtctcgcgc gtttcggtga tgacggtgaa     3840

aacctctgac acatgcagct cccggagacg gtcacagctt gtctgtaagc ggatgccggg     3900

agcagacaag cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg ctggcttaac     3960

tatgcggcat cagagcagat tgtactgaga gtgcaccata tggacatatt gtcgttagaa     4020

cgcggctaca attaatacat aaccttatgt atcatacaca tacgatttag gtgacactat     4080

agaaccagat ccccc                                                      4095


<210>  12
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide (Mature Salmom Growth Hormone)

<400>  12

Met Ile Glu Asn Gln Arg Leu Phe Asn Ile Ala Val Ser Arg Val Gln 
1               5                   10                  15      


His Leu His Leu Leu Ala Gln Lys Met Phe Asn Asp Phe Asp Gly Thr 
            20                  25                  30          


Leu Leu Pro Asp Glu Arg Arg Gln Leu Asn Lys Ile Phe Leu Leu Asp 
        35                  40                  45              


Phe Cys Asn Ser Asp Ser Ile Val Ser Pro Val Asp Lys His Glu Thr 
    50                  55                  60                  


Gln Lys Ser Ser Val Leu Lys Leu Leu His Ile Ser Phe Arg Leu Ile 
65                  70                  75                  80  


Glu Ser Trp Glu Tyr Pro Ser Gln Thr Leu Ile Ile Ser Asn Ser Leu 
                85                  90                  95      


Met Val Arg Asn Ala Asn Gln Ile Ser Glu Lys Leu Ser Asp Leu Lys 
            100                 105                 110         


Val Gly Ile Asn Leu Leu Ile Thr Gly Ser Gln Asp Gly Leu Leu Ser 
        115                 120                 125             


Leu Asp Asp Asn Asp Ser Gln Gln Leu Pro Pro Tyr Gly Asn Tyr Tyr 
    130                 135                 140                 


Gln Asn Leu Gly Gly Asp Gly Asn Val Arg Arg Asn Tyr Glu Leu Leu 
145                 150                 155                 160 


Ala Cys Phe Lys Lys Asp Met His Lys Val Glu Thr Tyr Leu Thr Val 
                165                 170                 175     


Ala Lys Cys Arg Lys Ser Leu Glu Ala Asn Cys Thr Leu 
            180                 185                 


<210>  13
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide (Phaeodactylum tricornutum Full Vacuole Leader 
       Sequence)

<400>  13

Met Ser Ile Arg Leu Phe Ser Thr Ala Leu Leu Ala Ala Cys Leu Ala 
1               5                   10                  15      


Lys Ala Thr Ala Gln Thr Cys Pro Thr Leu Ile Trp Ser Asp 
            20                  25                  30  


<210>  14
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  14
gccgccgtcc tcctccccgt cttgttggct gccccc                                 36


<210>  15
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  15
tacggacgta agaagcgtcg tcagcgccgt cgt                                    33


<210>  16
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  16
atgatgttca tgagaattgc cgtagcagca ctggccttgc tggctgctcc ctccattcgt       60

gccgaagagg ctggtgaaga ggccaagatg ggtaccgtg                              99


<210>  17
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  17
atgatgttca tgagaattgc cgtagcagca ctggccttgc tggctgctcc ctccattcgt       60

gccgaagagg ctggtgaaga ggccaagatg ggtaccgtga ttgaaaacca gcgtttgttc      120

aacattgccg tctcccgtgt ccagcacctc cacctcttgg cccagaagat gttcaacgac      180

ttcgacggaa ccctcctccc cgacgaacgt cgtcagctca acaagatttt cctcctcgac      240

ttctgcaact ccgactccat tgtctccccc gtcgacaagc acgaaaccca gaagtcctcc      300

gtcctcaagc tcctccacat ttccttccgc ctcatcgaat cctgggaata cccctcccag      360

accctcatta tttccaactc cctcatggtc cgcaacgcca accagatttc cgaaaagctc      420

tccgatctca aggtcggaat caacctcctc attaccggtt cccaggacgg actcctctcc      480

ctcgacgaca acgactccca gcagctcccc ccctacggaa actactacca gaacctcgga      540

ggcgacggaa acgtccgtcg taactacgaa ctcctcgcct gcttcaagaa ggacatgcac      600

aaggtcgaaa cctacctcac cgtcgccaag tgccgcaagt ccctcgaagc caactgcacc      660

ctctaa                                                                 666


<210>  18
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  18
atgtcgattc gtctcttctc taccgcctta ctagctgctt gcttagcaaa ggcaactgcc       60

caaactg                                                                 67


<210>  19
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  19
atgtcgattc gtctcttctc taccgcctta ctagctgctt gcttagcaaa ggcaactgcc       60

caaactggat ccattgaaaa ccagcgtttg ttcaacattg ccgtctcccg tgtccagcac      120

ctccacctct tggcccagaa gatgttcaac gacttcgacg gaaccctcct ccccgacgaa      180

cgtcgtcagc tcaacaagat tttcctcctc gacttctgca actccgactc cattgtctcc      240

cccgtcgaca agcacgaaac ccagaagtcc tccgtcctca agctcctcca catttccttc      300

cgcctcatcg aatcctggga atacccctcc cagaccctca ttatttccaa ctccctcatg      360

gtccgcaacg ccaaccagat ttccgaaaag ctctccgatc tcaaggtcgg aatcaacctc      420

ctcattaccg gttcccagga cggactcctc tccctcgacg acaacgactc ccagcagctc      480

cccccctacg gaaactacta ccagaacctc ggaggcgacg gaaacgtccg tcgtaactac      540

gaactcctcg cctgcttcaa gaaggacatg cacaaggtcg aaacctacct caccgtcgcc      600

aagtgccgca agtccctcga agccaactgc accctcagat ctggtggagg tggcggatac      660

ccgtacgacg tccctgatta cgccggatac ccttacgatg tcccggacta cgccggttcc      720

tacccctacg acgtcccgga ctacgccgcc cagtaa                                756


<210>  20
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide (agouti-related protein fragment)

<400>  20

Cys Ile Pro His Gln Gln Ser Cys Leu Gly His His Leu Pro Cys Cys 
1               5                   10                  15      


Asn Pro Cys Asp Thr Cys Tyr Cys Arg Phe Phe Lys Ala Phe Cys Tyr 
            20                  25                  30          


Cys Arg Ser Met Asp Asn Thr Cys Lys Asn Glu Tyr Ala 
        35                  40                  45  


<210>  21
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  21
tgcattccgc accagcagtc ctgcctcgga caccacctcc cgtgctgcaa cccctgcgac       60

acctgctact gtcgtttctt caaagccttc tgttactgcc gttccatgga caacacctgt      120

aagaacgaat acgcc                                                       135


<210>  22
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  22

Met Ser Ile Arg Leu Phe Ser Thr Ala Leu Leu Ala Ala Cys Leu Ala 
1               5                   10                  15      


Lys Ala Thr Ala Gln Thr Cys Ile Pro His Gln Gln Ser Cys Leu Gly 
            20                  25                  30          


His His Leu Pro Cys Cys Asn Pro Cys Asp Thr Cys Tyr Cys Arg Phe 
        35                  40                  45              


Phe Lys Ala Phe Cys Tyr Cys Arg Ser Met Asp Asn Thr Cys Lys Asn 
    50                  55                  60                  


Glu Tyr Ala 
65          


<210>  23
<211>  201
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  23
atgtccatcc gtctcttctc caccgccctc ttggccgcct gcctcgccaa ggccaccgct       60

cagacctgca ttccgcacca gcagtcctgc ctcggacacc acctcccgtg ctgcaacccc      120

tgcgacacct gctactgtcg tttcttcaaa gccttctgtt actgccgttc catggacaac      180

acctgtaaga acgaatacgc c                                                201


<210>  24
<211>  10
<212>  PRT
<213>  Gallus gallus

<400>  24

Gln His Trp Ser His Gly Trp Tyr Pro Gly 
1               5                   10  


<210>  25
<211>  30
<212>  DNA
<213>  Gallus gallus

<400>  25
cagcactggt cccacggatg gtaccccgga                                        30


<210>  26
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  26

Met Ser Ile Arg Leu Phe Ser Thr Ala Leu Leu Ala Ala Cys Leu Ala 
1               5                   10                  15      


Lys Ala Thr Ala Gln Thr Gln His Trp Ser His Gly Trp Tyr Pro Gly 
            20                  25                  30          


<210>  27
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  27
atgtccatcc gtctcttctc caccgccctc ttggccgcct gcctcgccaa ggccaccgct       60

cagacccagc actggtccca cggatggtac cccggaggaa agcgtgaact cgactccttt      120

ggaacctccg agatttccga agaaattaag ctctgcgagg ccggagaatg ttcctacctc      180

cgtccccagc gccgtggcgt gctccgttcc atcctcttgg acgccctcgc ccgtgaactc      240

caaaagcgta agtga                                                       255


<210>  28
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  28

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  29
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  29
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtaa      720


<210>  30
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  30

Met Ser Ile Arg Leu Phe Ser Thr Ala Leu Leu Ala Ala Cys Leu Ala 
1               5                   10                  15      


Lys Ala Thr Ala Gln Thr Gly Ser Met Val Ser Lys Gly Glu Glu Leu 
            20                  25                  30          


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
        35                  40                  45              


Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
    50                  55                  60                  


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
65                  70                  75                  80  


Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe 
                85                  90                  95      


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
            100                 105                 110         


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp 
        115                 120                 125             


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
    130                 135                 140                 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
145                 150                 155                 160 


Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
                165                 170                 175     


Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
            180                 185                 190         


Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
        195                 200                 205             


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
    210                 215                 220                 


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
225                 230                 235                 240 


Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu 
                245                 250                 255     


Gly Met Asp Glu Leu Tyr Lys 
            260             


<210>  31
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  31
atgtcgattc gtctcttctc taccgcctta ctagctgctt gcttagcaaa ggcaactgcc       60

caaactggat ccatggtgag caagggcgag gagctgttca ccggggtggt gcccatcctg      120

gtcgagctgg acggcgacgt aaacggccac aagttcagcg tgtccggcga gggcgagggc      180

gatgccacct acggcaagct gaccctgaag ttcatctgca ccaccggcaa gctgcccgtg      240

ccctggccca ccctcgtgac caccctgacc tacggcgtgc agtgcttcag ccgctacccc      300

gaccacatga agcagcacga cttcttcaag tccgccatgc ccgaaggcta cgtccaggag      360

cgcaccatct tcttcaagga cgacggcaac tacaagaccc gcgccgaggt gaagttcgag      420

ggcgacaccc tggtgaaccg catcgagctg aagggcatcg acttcaagga ggacggcaac      480

atcctggggc acaagctgga gtacaactac aacagccaca acgtctatat catggccgac      540

aagcagaaga acggcatcaa ggtgaacttc aagatccgcc acaacatcga ggacggcagc      600

gtgcagctcg ccgaccacta ccagcagaac acccccatcg gcgacggccc cgtgctgctg      660

cccgacaacc actacctgag cacccagtcc gccctgagca aagaccccaa cgagaagcgc      720

gatcacatgg tcctgctgga gttcgtgacc gccgccggga tcactctcgg catggacgag      780

ctgtacaagt aa                                                          792


<210>  32
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  32

Met Ser Ile Arg Leu Phe Ser Thr Ala Leu Leu Ala Ala Cys Leu Ala 
1               5                   10                  15      


Lys Ala Thr Ala Gln Thr Gly Ser Met Val Ser Lys Gly Glu Glu Leu 
            20                  25                  30          


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
        35                  40                  45              


Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
    50                  55                  60                  


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
65                  70                  75                  80  


Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe 
                85                  90                  95      


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
            100                 105                 110         


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp 
        115                 120                 125             


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
    130                 135                 140                 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
145                 150                 155                 160 


Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
                165                 170                 175     


Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
            180                 185                 190         


Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
        195                 200                 205             


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
    210                 215                 220                 


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
225                 230                 235                 240 


Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu 
                245                 250                 255     


Gly Met Asp Glu Leu Tyr Lys Lys Leu Ser Ala Ala Val Leu Leu Pro 
            260                 265                 270         


Val Leu Leu Ala Ala Pro 
        275             


<210>  33
<211>  838
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  33
atgtcgattc gtctcttctc taccgcctta ctagctgctt gcttagcaaa ggcaactgcc       60

caaactggat ccatggtgag caagggcgag gagctgttca ccggggtggt gcccatcctg      120

gtcgagctgg acggcgacgt aaacggccac aagttcagcg tgtccggcga gggcgagggc      180

gatgccacct acggcaagct gaccctgaag ttcatctgca ccaccggcaa gctgcccgtg      240

ccctggccca ccctcgtgac caccctgacc tacggcgtgc agtgcttcag ccgctacccc      300

gaccacatga agcagcacga cttcttcaag tccgccatgc ccgaaggcta cgtccaggag      360

cgcaccatct tcttcaagga cgacggcaac tacaagaccc gcgccgaggt gaagttcgag      420

ggcgacaccc tggtgaaccg catcgagctg aagggcatcg acttcaagga ggacggcaac      480

atcctggggc acaagctgga gtacaactac aacagccaca acgtctatat catggccgac      540

aagcagaaga acggcatcaa ggtgaacttc aagatccgcc acaacatcga ggacggcagc      600

gtgcagctcg ccgaccacta ccagcagaac acccccatcg gcgacggccc cgtgctgctg      660

cccgacaacc actacctgag cacccagtcc gccctgagca aagaccccaa cgagaagcgc      720

gatcacatgg tcctgctgga gttcgtgacc gccgccggga tcactctcgg catggacgag      780

ctgtacaaga agctttctgc cgccgtcctc ctccccgtct tgttggctgc ccccataa        838


<210>  34
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  34

Met Ser Ile Arg Leu Phe Ser Thr Ala Leu Leu Ala Ala Cys Leu Ala 
1               5                   10                  15      


Lys Ala Thr Ala Gln Thr Gly Ser Met Val Ser Lys Gly Glu Glu Leu 
            20                  25                  30          


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
        35                  40                  45              


Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
    50                  55                  60                  


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
65                  70                  75                  80  


Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe 
                85                  90                  95      


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
            100                 105                 110         


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp 
        115                 120                 125             


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
    130                 135                 140                 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
145                 150                 155                 160 


Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
                165                 170                 175     


Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
            180                 185                 190         


Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
        195                 200                 205             


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
    210                 215                 220                 


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
225                 230                 235                 240 


Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu 
                245                 250                 255     


Gly Met Asp Glu Leu Tyr Lys Lys Leu Tyr Gly Arg Lys Lys Arg Arg 
            260                 265                 270         


Gln Arg Arg Arg 
        275     


<210>  35
<211>  831
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  35
atgtcgattc gtctcttctc taccgcctta ctagctgctt gcttagcaaa ggcaactgcc       60

caaactggat ccatggtgag caagggcgag gagctgttca ccggggtggt gcccatcctg      120

gtcgagctgg acggcgacgt aaacggccac aagttcagcg tgtccggcga gggcgagggc      180

gatgccacct acggcaagct gaccctgaag ttcatctgca ccaccggcaa gctgcccgtg      240

ccctggccca ccctcgtgac caccctgacc tacggcgtgc agtgcttcag ccgctacccc      300

gaccacatga agcagcacga cttcttcaag tccgccatgc ccgaaggcta cgtccaggag      360

cgcaccatct tcttcaagga cgacggcaac tacaagaccc gcgccgaggt gaagttcgag      420

ggcgacaccc tggtgaaccg catcgagctg aagggcatcg acttcaagga ggacggcaac      480

atcctggggc acaagctgga gtacaactac aacagccaca acgtctatat catggccgac      540

aagcagaaga acggcatcaa ggtgaacttc aagatccgcc acaacatcga ggacggcagc      600

gtgcagctcg ccgaccacta ccagcagaac acccccatcg gcgacggccc cgtgctgctg      660

cccgacaacc actacctgag cacccagtcc gccctgagca aagaccccaa cgagaagcgc      720

gatcacatgg tcctgctgga gttcgtgacc gccgccggga tcactctcgg catggacgag      780

ctgtacaaga agctttacgg acgtaagaag cgtcgtcagc gccgtcgtta a               831


<210>  36
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  36
ggaattcatg atgttcatga gaattgc                                           27


<210>  37
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  37
acgctggttt tcaatcacgg tacccatctt                                        30


<210>  38
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  38
ggaattcatg atgttcatga gaattgc                                           27


<210>  39
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  39
acgctggttt tcaatcacgg tacccatctt                                        30


<210>  40
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  40
aagatgggta ccgtgattga aaaccagcgt                                        30


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  41
gagatctgag ggtgcagttg g                                                 21


<210>  42
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  42
ggaattcatg ggccaagtct ttctcttg                                          28


<210>  43
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  43
ggatccattg aaaaccagcg tttgttcaac                                        30


<210>  44
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  44
aagcttttac tgggcggcgt agtccgggac gtcgtagggg ta                          42


<210>  45
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  45
atgaattcat gtcgattcgt ctct                                              24


<210>  46
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  46
atggatccag tttgggcagt tgcc                                              24


<210>  47
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  47
tacccgtacg acgtccctga ttacgccgga tacccttacg atgtcccgga ctacgccggt       60

tcctacccct acgacgtccc ggactacgcc gcccagta                               98


