
                                SEQUENCE LISTING

<110> APPLICANT: Glaxo Group Limited

<120> TITLE: ANTIGEN BINDING POLYPEPTIDES
  

<130> DOCKET/FILE REFERENCE: PB65125

<160> NUMBER OF SEQUENCES: 105

<170> SOFTWARE: FastSEQ for Windows Version 4.0

<210> SEQ ID NO:1
<211> LENGTH: 5
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: 3E04 CDRH1

<400> SEQ ID NO:1
Ser Tyr Trp Met His
 1               5  


<210> SEQ ID NO:2
<211> LENGTH: 17
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: 3E04 CDRH2

<400> SEQ ID NO:2
Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Asn Gln Lys Phe Lys
 1               5                  10                  15      
Gly
    


<210> SEQ ID NO:3
<211> LENGTH: 9
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: 3E04 CDRH3

<400> SEQ ID NO:3
Gly Tyr Tyr Tyr Asp Ser Ser Tyr Asp
 1               5                  


<210> SEQ ID NO:4
<211> LENGTH: 11
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: 3E04 CDRL1

<400> SEQ ID NO:4
Arg Ala Ser Glu Asn Ile Tyr Ser Tyr Leu Ala
 1               5                  10      


<210> SEQ ID NO:5
<211> LENGTH: 7
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: 3E04 CDRL2

<400> SEQ ID NO:5
Asn Ala Lys Thr Leu Ala Glu
 1               5          


<210> SEQ ID NO:6
<211> LENGTH: 9
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: 3E04 CDRL3

<400> SEQ ID NO:6
Gln His His Tyr Gly Thr Pro Leu Thr
 1               5                  


<210> SEQ ID NO:7
<211> LENGTH: 119
<212> TYPE: PRT
<213> ORGANISM:Murine

<400> SEQ ID NO:7
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Phe
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ile Gly Tyr Tyr Tyr Asp Ser Ser Tyr Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Thr Leu Thr Val Ser Ser
        115                 


<210> SEQ ID NO:8
<211> LENGTH: 107
<212> TYPE: PRT
<213> ORGANISM:Murine

<400> SEQ ID NO:8
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Glu Thr Ile Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
        35                  40                  45              
Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Leu
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> SEQ ID NO:9
<211> LENGTH: 19
<212> TYPE: PRT
<213> ORGANISM:Murine

<400> SEQ ID NO:9
Met Lys Cys Ser Trp Val Met Phe Phe Leu Val Ala Thr Ala Thr Gly
 1               5                  10                  15      
Val His Ser
            


<210> SEQ ID NO:10
<211> LENGTH: 18
<212> TYPE: PRT
<213> ORGANISM:Murine

<400> SEQ ID NO:10
Met Lys Leu Pro Val Arg Leu Val Val Leu Leu Trp Leu Thr Gly Ala
 1               5                  10                  15      
Arg Cys
        


<210> SEQ ID NO:11
<211> LENGTH: 449
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: 3E04 chimera - DMS10031 heavy chain

<400> SEQ ID NO:11
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Phe
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ile Gly Tyr Tyr Tyr Asp Ser Ser Tyr Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> SEQ ID NO:12
<211> LENGTH: 214
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: 3E04 chimera - DMS10031 light chain

<400> SEQ ID NO:12
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Glu Thr Ile Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
        35                  40                  45              
Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Leu
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> SEQ ID NO:13
<211> LENGTH: 119
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: 3E04 humanised VH - DMS10064 VH

<400> SEQ ID NO:13
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ile Gly Tyr Tyr Tyr Asp Ser Ser Tyr Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> SEQ ID NO:14
<211> LENGTH: 107
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: 3E04 humanised VH - DMS10064 VL

<400> SEQ ID NO:14
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Leu
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> SEQ ID NO:15
<211> LENGTH: 19
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Signal peptide sequence for the humanised VH and
      VL
      

<400> SEQ ID NO:15
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
 1               5                  10                  15      
Val His Ser
            


<210> SEQ ID NO:16
<211> LENGTH: 447
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised heavy chain for DMS10064
      

<400> SEQ ID NO:16
Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val
 1               5                  10                  15      
Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met
            20                  25                  30          
His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg
        35                  40                  45              
Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Asn Gln Lys Phe Lys Gly
    50                  55                  60                  
Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu
65                  70                  75                  80  
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ile
                85                  90                  95      
Gly Tyr Tyr Tyr Asp Ser Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110         
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu
        115                 120                 125             
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys
    130                 135                 140                 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser
145                 150                 155                 160 
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser
                165                 170                 175     
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser
            180                 185                 190         
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn
        195                 200                 205             
Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His
    210                 215                 220                 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu
            260                 265                 270         
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
            340                 345                 350         
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
                405                 410                 415     
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445         


<210> SEQ ID NO:17
<211> LENGTH: 214
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised light chain for DMS10064
      

<400> SEQ ID NO:17
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Leu
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> SEQ ID NO:18
<211> LENGTH: 449
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised heavy chain for DMS10079
      

<400> SEQ ID NO:18
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ile Gly Tyr Tyr Tyr Asp Ser Ser Tyr Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> SEQ ID NO:19
<211> LENGTH: 449
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised heavy chain for DMS10080
      
      

<400> SEQ ID NO:19
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ile Gly Tyr Tyr Tyr Asp Ser Ser Tyr Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> SEQ ID NO:20
<211> LENGTH: 449
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised heavy chain for DMS10081
      
      

<400> SEQ ID NO:20
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Tyr Tyr Tyr Asp Ser Ser Tyr Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> SEQ ID NO:21
<211> LENGTH: 449
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised heavy chain for DMS10082
      
      

<400> SEQ ID NO:21
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ile Gly Tyr Tyr Tyr Asp Ser Ser Tyr Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> SEQ ID NO:22
<211> LENGTH: 449
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised heavy chain for DMS10083
      
      

<400> SEQ ID NO:22
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Tyr Tyr Tyr Asp Ser Ser Tyr Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> SEQ ID NO:23
<211> LENGTH: 449
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised heavy chain for DMS10084
      
      

<400> SEQ ID NO:23
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Tyr Tyr Tyr Asp Ser Ser Tyr Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> SEQ ID NO:24
<211> LENGTH: 449
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised heavy chain for DMS10085
      
      

<400> SEQ ID NO:24
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Tyr Tyr Tyr Asp Ser Ser Tyr Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> SEQ ID NO:25
<211> LENGTH: 1347
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: 3E04 chimera - DMS10031 heavy chain
      
      

<400> SEQ ID NO:25
caggtccaac tgcagcagcc tggggctgaa ctggtgaagc ctggggcttc agtgaaggtg 60
tcctgcaagg cttctggcta caccttcacc agctactgga tgcactgggt gaagcagagg 120
cctggccaag gccttgagtg gattggaagg attcatcctt ctgatagtga tactaactac 180
aatcaaaagt tcaagggcaa ggccacattg actgtagaca aatcctccag cacagccttc 240
atgcagctca gcagcctgac atctgaggac tctgcggtct attactgtgc aataggttat 300
tactacgata gtagctacga ctactggggc caaggcacca ctctcacagt ctcctcagcc 360
aaaacaacac cccccagcgt gttccccctg gcccccagca gcaagagcac cagcggcggc 420
acagccgccc tgggctgcct ggtgaaggac tacttccccg aaccggtgac cgtgtcctgg 480
aacagcggag ccctgaccag cggcgtgcac accttccccg ccgtgctgca gagcagcggc 540
ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca gcctgggcac ccagacctac 600
atctgtaacg tgaaccacaa gcccagcaac accaaggtgg acaagaaggt ggagcccaag 660
agctgtgaca agacccacac ctgccccccc tgccctgccc ccgagctgct gggaggcccc 720
agcgtgttcc tgttcccccc caagcctaag gacaccctga tgatcagcag aacccccgag 780
gtgacctgtg tggtggtgga tgtgagccac gaggaccctg aggtgaagtt caactggtac 840
gtggacggcg tggaggtgca caatgccaag accaagccca gggaggagca gtacaacagc 900
acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg attggctgaa cggcaaggag 960
tacaagtgta aggtgtccaa caaggccctg cctgccccta tcgagaaaac catcagcaag 1020
gccaagggcc agcccagaga gccccaggtg tacaccctgc cccctagcag agatgagctg 1080
accaagaacc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc 1140
gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg 1200
gacagcgatg gcagcttctt cctgtacagc aagctgaccg tggacaagag cagatggcag 1260
cagggcaacg tgttcagctg ctccgtgatg cacgaggccc tgcacaatca ctacacccag 1320
aagagcctga gcctgtcccc tggcaag                                     1347

<210> SEQ ID NO:26
<211> LENGTH: 642
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: 3E04 chimera - DMS10031 light chain
      
      

<400> SEQ ID NO:26
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactatcacc 60
atcacatgtc gagcaagtga gaatatttac agttatttag catggtatca gcagaaacag 120
ggaaaatctc ctcagctcct ggtctataat gcaaaaacct tagcagaagg tgtgccatca 180
aggttcagtg gcagtggatc aggcacacag ttttctctga agatcaacag cctgcagcct 240
gaagattttg ggagttatta ctgtcaacat cattatggta ctccgctcac gttcggtgct 300
gggaccaagc tggagctgaa acgtacggtg gccgccccca gcgtgttcat cttccccccc 360
agcgatgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac 420
ccccgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag 480
gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540
ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc 600
ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gc                    642

<210> SEQ ID NO:27
<211> LENGTH: 1341
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised heavy hain for DMS10064
      
      

<400> SEQ ID NO:27
cagctggtgc agagcggcgc cgaggtgaag aagcccggca gcagcgtgaa ggtgagctgc 60
aaggccagcg gctacacctt caccagctac tggatgcact gggtgaggca ggcccccggc 120
cagggcctgg agtggatggg caggatccac cccagcgaca gcgacaccaa ctacaaccag 180
aagttcaagg gcagggtgac catcaccgcc gacaagagca ccagcaccgc ctacatggag 240
ctgagcagcc tgaggagcga ggacaccgcc gtgtactact gcgccatcgg ctactactac 300
gacagcagct acgactactg gggccagggc acactagtga ccgtgtccag cgccagcacc 360
aagggcccca gcgtgttccc cctggccccc agcagcaaga gcaccagcgg cggcacagcc 420
gccctgggct gcctggtgaa ggactacttc cccgaaccgg tgaccgtgtc ctggaacagc 480
ggagccctga ccagcggcgt gcacaccttc cccgccgtgc tgcagagcag cggcctgtac 540
agcctgagca gcgtggtgac cgtgcccagc agcagcctgg gcacccagac ctacatctgt 600
aacgtgaacc acaagcccag caacaccaag gtggacaaga aggtggagcc caagagctgt 660
gacaagaccc acacctgccc cccctgccct gcccccgagc tgctgggagg ccccagcgtg 720
ttcctgttcc cccccaagcc taaggacacc ctgatgatca gcagaacccc cgaggtgacc 780
tgtgtggtgg tggatgtgag ccacgaggac cctgaggtga agttcaactg gtacgtggac 840
ggcgtggagg tgcacaatgc caagaccaag cccagggagg agcagtacaa cagcacctac 900
cgggtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa ggagtacaag 960
tgtaaggtgt ccaacaaggc cctgcctgcc cctatcgaga aaaccatcag caaggccaag 1020
ggccagccca gagagcccca ggtgtacacc ctgcccccta gcagagatga gctgaccaag 1080
aaccaggtgt ccctgacctg cctggtgaag ggcttctacc ccagcgacat cgccgtggag 1140
tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc 1200
gatggcagct tcttcctgta cagcaagctg accgtggaca agagcagatg gcagcagggc 1260
aacgtgttca gctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagagc 1320
ctgagcctgt cccctggcaa g                                           1341

<210> SEQ ID NO:28
<211> LENGTH: 642
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised light  chain for DMS10064
      
      

<400> SEQ ID NO:28
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc 60
atcacctgca gggccagcga gaacatctac agctacctgg cctggtacca gcagaagccc 120
ggcaaggccc ccaagctgct gatctacaac gccaagaccc tggccgaggg cgtgcccagc 180
aggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc 240
gaggacttcg ccacctacta ctgccagcac cactacggca cccccctgac cttcggccag 300
ggcaccaagc tggagatcaa gcgtacggtg gccgccccca gcgtgttcat cttccccccc 360
agcgatgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac 420
ccccgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag 480
gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540
ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc 600
ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gc                    642

<210> SEQ ID NO:29
<211> LENGTH: 1347
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised heavy chain for DMS10079
      
      

<400> SEQ ID NO:29
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcagcag cgtgaaggtg 60
agctgcaagg ccagcggcgg caccttcacc agctactgga tgcactgggt gaggcaggcc 120
cccggccagg gcctggagtg gatgggcagg atccacccca gcgacagcga caccaactac 180
aaccagaagt tcaagggcag ggtgaccatc accgccgaca agagcaccag caccgcctac 240
atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc catcggctac 300
tactacgaca gcagctacga ctactggggc cagggcacac tagtgaccgt gtccagcgcc 360
agcaccaagg gccccagcgt gttccccctg gcccccagca gcaagagcac cagcggcggc 420
acagccgccc tgggctgcct ggtgaaggac tacttccccg aaccggtgac cgtgtcctgg 480
aacagcggag ccctgaccag cggcgtgcac accttccccg ccgtgctgca gagcagcggc 540
ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca gcctgggcac ccagacctac 600
atctgtaacg tgaaccacaa gcccagcaac accaaggtgg acaagaaggt ggagcccaag 660
agctgtgaca agacccacac ctgccccccc tgccctgccc ccgagctgct gggaggcccc 720
agcgtgttcc tgttcccccc caagcctaag gacaccctga tgatcagcag aacccccgag 780
gtgacctgtg tggtggtgga tgtgagccac gaggaccctg aggtgaagtt caactggtac 840
gtggacggcg tggaggtgca caatgccaag accaagccca gggaggagca gtacaacagc 900
acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg attggctgaa cggcaaggag 960
tacaagtgta aggtgtccaa caaggccctg cctgccccta tcgagaaaac catcagcaag 1020
gccaagggcc agcccagaga gccccaggtg tacaccctgc cccctagcag agatgagctg 1080
accaagaacc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc 1140
gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg 1200
gacagcgatg gcagcttctt cctgtacagc aagctgaccg tggacaagag cagatggcag 1260
cagggcaacg tgttcagctg ctccgtgatg cacgaggccc tgcacaatca ctacacccag 1320
aagagcctga gcctgtcccc tggcaag                                     1347

<210> SEQ ID NO:30
<211> LENGTH: 1347
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised heavy chain for DMS10080
      
      

<400> SEQ ID NO:30
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcagcag cgtgaaggtg 60
agctgcaagg ccagcggcta caccttcagc agctactgga tgcactgggt gaggcaggcc 120
cccggccagg gcctggagtg gatgggcagg atccacccca gcgacagcga caccaactac 180
aaccagaagt tcaagggcag ggtgaccatc accgccgaca agagcaccag caccgcctac 240
atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc catcggctac 300
tactacgaca gcagctacga ctactggggc cagggcacac tagtgaccgt gtccagcgcc 360
agcaccaagg gccccagcgt gttccccctg gcccccagca gcaagagcac cagcggcggc 420
acagccgccc tgggctgcct ggtgaaggac tacttccccg aaccggtgac cgtgtcctgg 480
aacagcggag ccctgaccag cggcgtgcac accttccccg ccgtgctgca gagcagcggc 540
ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca gcctgggcac ccagacctac 600
atctgtaacg tgaaccacaa gcccagcaac accaaggtgg acaagaaggt ggagcccaag 660
agctgtgaca agacccacac ctgccccccc tgccctgccc ccgagctgct gggaggcccc 720
agcgtgttcc tgttcccccc caagcctaag gacaccctga tgatcagcag aacccccgag 780
gtgacctgtg tggtggtgga tgtgagccac gaggaccctg aggtgaagtt caactggtac 840
gtggacggcg tggaggtgca caatgccaag accaagccca gggaggagca gtacaacagc 900
acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg attggctgaa cggcaaggag 960
tacaagtgta aggtgtccaa caaggccctg cctgccccta tcgagaaaac catcagcaag 1020
gccaagggcc agcccagaga gccccaggtg tacaccctgc cccctagcag agatgagctg 1080
accaagaacc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc 1140
gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg 1200
gacagcgatg gcagcttctt cctgtacagc aagctgaccg tggacaagag cagatggcag 1260
cagggcaacg tgttcagctg ctccgtgatg cacgaggccc tgcacaatca ctacacccag 1320
aagagcctga gcctgtcccc tggcaag                                     1347

<210> SEQ ID NO:31
<211> LENGTH: 1347
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised heavy chain for DMS10081
      
      

<400> SEQ ID NO:31
Cys Ala Gly Gly Thr Gly Cys Ala Gly Cys Thr Gly Gly Thr Gly Cys
 1               5                  10                  15      
Ala Gly Ala Gly Cys Gly Gly Cys Gly Cys Cys Gly Ala Gly Gly Thr
            20                  25                  30          
Gly Ala Ala Gly Ala Ala Gly Cys Cys Cys Gly Gly Cys Ala Gly Cys
        35                  40                  45              
Ala Gly Cys Gly Thr Gly Ala Ala Gly Gly Thr Gly Ala Gly Cys Thr
    50                  55                  60                  
Gly Cys Ala Ala Gly Gly Cys Cys Ala Gly Cys Gly Gly Cys Thr Ala
65                  70                  75                  80  
Cys Ala Cys Cys Thr Thr Cys Ala Cys Cys Ala Gly Cys Thr Ala Cys
                85                  90                  95      
Thr Gly Gly Ala Thr Gly Cys Ala Cys Thr Gly Gly Gly Thr Gly Ala
            100                 105                 110         
Gly Gly Cys Ala Gly Gly Cys Cys Cys Cys Cys Gly Gly Cys Cys Ala
        115                 120                 125             
Gly Gly Gly Cys Cys Thr Gly Gly Ala Gly Thr Gly Gly Ala Thr Gly
    130                 135                 140                 
Gly Gly Cys Ala Gly Gly Ala Thr Cys Cys Ala Cys Cys Cys Cys Ala
145                 150                 155                 160 
Gly Cys Gly Ala Cys Ala Gly Cys Gly Ala Cys Ala Cys Cys Ala Ala
                165                 170                 175     
Cys Thr Ala Cys Ala Ala Cys Cys Ala Gly Ala Ala Gly Thr Thr Cys
            180                 185                 190         
Ala Ala Gly Gly Gly Cys Ala Gly Gly Gly Thr Gly Ala Cys Cys Ala
        195                 200                 205             
Thr Cys Ala Cys Cys Gly Cys Cys Gly Ala Cys Ala Ala Gly Ala Gly
    210                 215                 220                 
Cys Ala Cys Cys Ala Gly Cys Ala Cys Cys Gly Cys Cys Thr Ala Cys
225                 230                 235                 240 
Ala Thr Gly Gly Ala Gly Cys Thr Gly Ala Gly Cys Ala Gly Cys Cys
                245                 250                 255     
Thr Gly Ala Gly Gly Ala Gly Cys Gly Ala Gly Gly Ala Cys Ala Cys
            260                 265                 270         
Cys Gly Cys Cys Gly Thr Gly Thr Ala Cys Thr Ala Cys Thr Gly Cys
        275                 280                 285             
Gly Cys Cys Ala Gly Gly Gly Gly Cys Thr Ala Cys Thr Ala Cys Thr
    290                 295                 300                 
Ala Cys Gly Ala Cys Ala Gly Cys Ala Gly Cys Thr Ala Cys Gly Ala
305                 310                 315                 320 
Cys Thr Ala Cys Thr Gly Gly Gly Gly Cys Cys Ala Gly Gly Gly Cys
                325                 330                 335     
Ala Cys Ala Cys Thr Ala Gly Thr Gly Ala Cys Cys Gly Thr Gly Thr
            340                 345                 350         
Cys Cys Ala Gly Cys Gly Cys Cys Ala Gly Cys Ala Cys Cys Ala Ala
        355                 360                 365             
Gly Gly Gly Cys Cys Cys Cys Ala Gly Cys Gly Thr Gly Thr Thr Cys
    370                 375                 380                 
Cys Cys Cys Cys Thr Gly Gly Cys Cys Cys Cys Cys Ala Gly Cys Ala
385                 390                 395                 400 
Gly Cys Ala Ala Gly Ala Gly Cys Ala Cys Cys Ala Gly Cys Gly Gly
                405                 410                 415     
Cys Gly Gly Cys Ala Cys Ala Gly Cys Cys Gly Cys Cys Cys Thr Gly
            420                 425                 430         
Gly Gly Cys Thr Gly Cys Cys Thr Gly Gly Thr Gly Ala Ala Gly Gly
        435                 440                 445             
Ala Cys Thr Ala Cys Thr Thr Cys Cys Cys Cys Gly Ala Ala Cys Cys
    450                 455                 460                 
Gly Gly Thr Gly Ala Cys Cys Gly Thr Gly Thr Cys Cys Thr Gly Gly
465                 470                 475                 480 
Ala Ala Cys Ala Gly Cys Gly Gly Ala Gly Cys Cys Cys Thr Gly Ala
                485                 490                 495     
Cys Cys Ala Gly Cys Gly Gly Cys Gly Thr Gly Cys Ala Cys Ala Cys
            500                 505                 510         
Cys Thr Thr Cys Cys Cys Cys Gly Cys Cys Gly Thr Gly Cys Thr Gly
        515                 520                 525             
Cys Ala Gly Ala Gly Cys Ala Gly Cys Gly Gly Cys Cys Thr Gly Thr
    530                 535                 540                 
Ala Cys Ala Gly Cys Cys Thr Gly Ala Gly Cys Ala Gly Cys Gly Thr
545                 550                 555                 560 
Gly Gly Thr Gly Ala Cys Cys Gly Thr Gly Cys Cys Cys Ala Gly Cys
                565                 570                 575     
Ala Gly Cys Ala Gly Cys Cys Thr Gly Gly Gly Cys Ala Cys Cys Cys
            580                 585                 590         
Ala Gly Ala Cys Cys Thr Ala Cys Ala Thr Cys Thr Gly Thr Ala Ala
        595                 600                 605             
Cys Gly Thr Gly Ala Ala Cys Cys Ala Cys Ala Ala Gly Cys Cys Cys
    610                 615                 620                 
Ala Gly Cys Ala Ala Cys Ala Cys Cys Ala Ala Gly Gly Thr Gly Gly
625                 630                 635                 640 
Ala Cys Ala Ala Gly Ala Ala Gly Gly Thr Gly Gly Ala Gly Cys Cys
                645                 650                 655     
Cys Ala Ala Gly Ala Gly Cys Thr Gly Thr Gly Ala Cys Ala Ala Gly
            660                 665                 670         
Ala Cys Cys Cys Ala Cys Ala Cys Cys Thr Gly Cys Cys Cys Cys Cys
        675                 680                 685             
Cys Cys Thr Gly Cys Cys Cys Thr Gly Cys Cys Cys Cys Cys Gly Ala
    690                 695                 700                 
Gly Cys Thr Gly Cys Thr Gly Gly Gly Ala Gly Gly Cys Cys Cys Cys
705                 710                 715                 720 
Ala Gly Cys Gly Thr Gly Thr Thr Cys Cys Thr Gly Thr Thr Cys Cys
                725                 730                 735     
Cys Cys Cys Cys Cys Ala Ala Gly Cys Cys Thr Ala Ala Gly Gly Ala
            740                 745                 750         
Cys Ala Cys Cys Cys Thr Gly Ala Thr Gly Ala Thr Cys Ala Gly Cys
        755                 760                 765             
Ala Gly Ala Ala Cys Cys Cys Cys Cys Gly Ala Gly Gly Thr Gly Ala
    770                 775                 780                 
Cys Cys Thr Gly Thr Gly Thr Gly Gly Thr Gly Gly Thr Gly Gly Ala
785                 790                 795                 800 
Thr Gly Thr Gly Ala Gly Cys Cys Ala Cys Gly Ala Gly Gly Ala Cys
                805                 810                 815     
Cys Cys Thr Gly Ala Gly Gly Thr Gly Ala Ala Gly Thr Thr Cys Ala
            820                 825                 830         
Ala Cys Thr Gly Gly Thr Ala Cys Gly Thr Gly Gly Ala Cys Gly Gly
        835                 840                 845             
Cys Gly Thr Gly Gly Ala Gly Gly Thr Gly Cys Ala Cys Ala Ala Thr
    850                 855                 860                 
Gly Cys Cys Ala Ala Gly Ala Cys Cys Ala Ala Gly Cys Cys Cys Ala
865                 870                 875                 880 
Gly Gly Gly Ala Gly Gly Ala Gly Cys Ala Gly Thr Ala Cys Ala Ala
                885                 890                 895     
Cys Ala Gly Cys Ala Cys Cys Thr Ala Cys Cys Gly Gly Gly Thr Gly
            900                 905                 910         
Gly Thr Gly Thr Cys Cys Gly Thr Gly Cys Thr Gly Ala Cys Cys Gly
        915                 920                 925             
Thr Gly Cys Thr Gly Cys Ala Cys Cys Ala Gly Gly Ala Thr Thr Gly
    930                 935                 940                 
Gly Cys Thr Gly Ala Ala Cys Gly Gly Cys Ala Ala Gly Gly Ala Gly
945                 950                 955                 960 
Thr Ala Cys Ala Ala Gly Thr Gly Thr Ala Ala Gly Gly Thr Gly Thr
                965                 970                 975     
Cys Cys Ala Ala Cys Ala Ala Gly Gly Cys Cys Cys Thr Gly Cys Cys
            980                 985                 990         
Thr Gly Cys Cys Cys Cys Thr Ala Thr Cys Gly Ala Gly Ala Ala Ala
        995                 1000                1005            
Ala Cys Cys Ala Thr Cys Ala Gly Cys Ala Ala Gly Gly Cys Cys Ala
    1010                1015                1020                
Ala Gly Gly Gly Cys Cys Ala Gly Cys Cys Cys Ala Gly Ala Gly Ala
1025                1030                1035                1040
Gly Cys Cys Cys Cys Ala Gly Gly Thr Gly Thr Ala Cys Ala Cys Cys
                1045                1050                1055    
Cys Thr Gly Cys Cys Cys Cys Cys Thr Ala Gly Cys Ala Gly Ala Gly
            1060                1065                1070        
Ala Thr Gly Ala Gly Cys Thr Gly Ala Cys Cys Ala Ala Gly Ala Ala
        1075                1080                1085            
Cys Cys Ala Gly Gly Thr Gly Thr Cys Cys Cys Thr Gly Ala Cys Cys
    1090                1095                1100                
Thr Gly Cys Cys Thr Gly Gly Thr Gly Ala Ala Gly Gly Gly Cys Thr
1105                1110                1115                1120
Thr Cys Thr Ala Cys Cys Cys Cys Ala Gly Cys Gly Ala Cys Ala Thr
                1125                1130                1135    
Cys Gly Cys Cys Gly Thr Gly Gly Ala Gly Thr Gly Gly Gly Ala Gly
            1140                1145                1150        
Ala Gly Cys Ala Ala Cys Gly Gly Cys Cys Ala Gly Cys Cys Cys Gly
        1155                1160                1165            
Ala Gly Ala Ala Cys Ala Ala Cys Thr Ala Cys Ala Ala Gly Ala Cys
    1170                1175                1180                
Cys Ala Cys Cys Cys Cys Cys Cys Cys Thr Gly Thr Gly Cys Thr Gly
1185                1190                1195                1200
Gly Ala Cys Ala Gly Cys Gly Ala Thr Gly Gly Cys Ala Gly Cys Thr
                1205                1210                1215    
Thr Cys Thr Thr Cys Cys Thr Gly Thr Ala Cys Ala Gly Cys Ala Ala
            1220                1225                1230        
Gly Cys Thr Gly Ala Cys Cys Gly Thr Gly Gly Ala Cys Ala Ala Gly
        1235                1240                1245            
Ala Gly Cys Ala Gly Ala Thr Gly Gly Cys Ala Gly Cys Ala Gly Gly
    1250                1255                1260                
Gly Cys Ala Ala Cys Gly Thr Gly Thr Thr Cys Ala Gly Cys Thr Gly
1265                1270                1275                1280
Cys Thr Cys Cys Gly Thr Gly Ala Thr Gly Cys Ala Cys Gly Ala Gly
                1285                1290                1295    
Gly Cys Cys Cys Thr Gly Cys Ala Cys Ala Ala Thr Cys Ala Cys Thr
            1300                1305                1310        
Ala Cys Ala Cys Cys Cys Ala Gly Ala Ala Gly Ala Gly Cys Cys Thr
        1315                1320                1325            
Gly Ala Gly Cys Cys Thr Gly Thr Cys Cys Cys Cys Thr Gly Gly Cys
    1330                1335                1340                
Ala Ala Gly
1345        


<210> SEQ ID NO:32
<211> LENGTH: 1347
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised heavy chain for DMS10082
      
      

<400> SEQ ID NO:32
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcagcag cgtgaaggtg 60
agctgcaagg ccagcggcgg caccttcagc agctactgga tgcactgggt gaggcaggcc 120
cccggccagg gcctggagtg gatgggcagg atccacccca gcgacagcga caccaactac 180
aaccagaagt tcaagggcag ggtgaccatc accgccgaca agagcaccag caccgcctac 240
atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc catcggctac 300
tactacgaca gcagctacga ctactggggc cagggcacac tagtgaccgt gtccagcgcc 360
agcaccaagg gccccagcgt gttccccctg gcccccagca gcaagagcac cagcggcggc 420
acagccgccc tgggctgcct ggtgaaggac tacttccccg aaccggtgac cgtgtcctgg 480
aacagcggag ccctgaccag cggcgtgcac accttccccg ccgtgctgca gagcagcggc 540
ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca gcctgggcac ccagacctac 600
atctgtaacg tgaaccacaa gcccagcaac accaaggtgg acaagaaggt ggagcccaag 660
agctgtgaca agacccacac ctgccccccc tgccctgccc ccgagctgct gggaggcccc 720
agcgtgttcc tgttcccccc caagcctaag gacaccctga tgatcagcag aacccccgag 780
gtgacctgtg tggtggtgga tgtgagccac gaggaccctg aggtgaagtt caactggtac 840
gtggacggcg tggaggtgca caatgccaag accaagccca gggaggagca gtacaacagc 900
acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg attggctgaa cggcaaggag 960
tacaagtgta aggtgtccaa caaggccctg cctgccccta tcgagaaaac catcagcaag 1020
gccaagggcc agcccagaga gccccaggtg tacaccctgc cccctagcag agatgagctg 1080
accaagaacc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc 1140
gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg 1200
gacagcgatg gcagcttctt cctgtacagc aagctgaccg tggacaagag cagatggcag 1260
cagggcaacg tgttcagctg ctccgtgatg cacgaggccc tgcacaatca ctacacccag 1320
aagagcctga gcctgtcccc tggcaag                                     1347

<210> SEQ ID NO:33
<211> LENGTH: 1347
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised heavy chain for DMS10083
      
      

<400> SEQ ID NO:33
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcagcag cgtgaaggtg 60
agctgcaagg ccagcggcta caccttcagc agctactgga tgcactgggt gaggcaggcc 120
cccggccagg gcctggagtg gatgggcagg atccacccca gcgacagcga caccaactac 180
aaccagaagt tcaagggcag ggtgaccatc accgccgaca agagcaccag caccgcctac 240
atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caggggctac 300
tactacgaca gcagctacga ctactggggc cagggcacac tagtgaccgt gtccagcgcc 360
agcaccaagg gccccagcgt gttccccctg gcccccagca gcaagagcac cagcggcggc 420
acagccgccc tgggctgcct ggtgaaggac tacttccccg aaccggtgac cgtgtcctgg 480
aacagcggag ccctgaccag cggcgtgcac accttccccg ccgtgctgca gagcagcggc 540
ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca gcctgggcac ccagacctac 600
atctgtaacg tgaaccacaa gcccagcaac accaaggtgg acaagaaggt ggagcccaag 660
agctgtgaca agacccacac ctgccccccc tgccctgccc ccgagctgct gggaggcccc 720
agcgtgttcc tgttcccccc caagcctaag gacaccctga tgatcagcag aacccccgag 780
gtgacctgtg tggtggtgga tgtgagccac gaggaccctg aggtgaagtt caactggtac 840
gtggacggcg tggaggtgca caatgccaag accaagccca gggaggagca gtacaacagc 900
acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg attggctgaa cggcaaggag 960
tacaagtgta aggtgtccaa caaggccctg cctgccccta tcgagaaaac catcagcaag 1020
gccaagggcc agcccagaga gccccaggtg tacaccctgc cccctagcag agatgagctg 1080
accaagaacc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc 1140
gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg 1200
gacagcgatg gcagcttctt cctgtacagc aagctgaccg tggacaagag cagatggcag 1260
cagggcaacg tgttcagctg ctccgtgatg cacgaggccc tgcacaatca ctacacccag 1320
aagagcctga gcctgtcccc tggcaag                                     1347

<210> SEQ ID NO:34
<211> LENGTH: 1347
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised heavy chain for DMS10084
      
      

<400> SEQ ID NO:34
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcagcag cgtgaaggtg 60
agctgcaagg ccagcggcgg caccttcacc agctactgga tgcactgggt gaggcaggcc 120
cccggccagg gcctggagtg gatgggcagg atccacccca gcgacagcga caccaactac 180
aaccagaagt tcaagggcag ggtgaccatc accgccgaca agagcaccag caccgcctac 240
atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caggggctac 300
tactacgaca gcagctacga ctactggggc cagggcacac tagtgaccgt gtccagcgcc 360
agcaccaagg gccccagcgt gttccccctg gcccccagca gcaagagcac cagcggcggc 420
acagccgccc tgggctgcct ggtgaaggac tacttccccg aaccggtgac cgtgtcctgg 480
aacagcggag ccctgaccag cggcgtgcac accttccccg ccgtgctgca gagcagcggc 540
ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca gcctgggcac ccagacctac 600
atctgtaacg tgaaccacaa gcccagcaac accaaggtgg acaagaaggt ggagcccaag 660
agctgtgaca agacccacac ctgccccccc tgccctgccc ccgagctgct gggaggcccc 720
agcgtgttcc tgttcccccc caagcctaag gacaccctga tgatcagcag aacccccgag 780
gtgacctgtg tggtggtgga tgtgagccac gaggaccctg aggtgaagtt caactggtac 840
gtggacggcg tggaggtgca caatgccaag accaagccca gggaggagca gtacaacagc 900
acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg attggctgaa cggcaaggag 960
tacaagtgta aggtgtccaa caaggccctg cctgccccta tcgagaaaac catcagcaag 1020
gccaagggcc agcccagaga gccccaggtg tacaccctgc cccctagcag agatgagctg 1080
accaagaacc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc 1140
gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg 1200
gacagcgatg gcagcttctt cctgtacagc aagctgaccg tggacaagag cagatggcag 1260
cagggcaacg tgttcagctg ctccgtgatg cacgaggccc tgcacaatca ctacacccag 1320
aagagcctga gcctgtcccc tggcaag                                     1347

<210> SEQ ID NO:35
<211> LENGTH: 1347
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised heavy chain for DMS10085
      
      

<400> SEQ ID NO:35
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcagcag cgtgaaggtg 60
agctgcaagg ccagcggcgg caccttcagc agctactgga tgcactgggt gaggcaggcc 120
cccggccagg gcctggagtg gatgggcagg atccacccca gcgacagcga caccaactac 180
aaccagaagt tcaagggcag ggtgaccatc accgccgaca agagcaccag caccgcctac 240
atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caggggctac 300
tactacgaca gcagctacga ctactggggc cagggcacac tagtgaccgt gtccagcgcc 360
agcaccaagg gccccagcgt gttccccctg gcccccagca gcaagagcac cagcggcggc 420
acagccgccc tgggctgcct ggtgaaggac tacttccccg aaccggtgac cgtgtcctgg 480
aacagcggag ccctgaccag cggcgtgcac accttccccg ccgtgctgca gagcagcggc 540
ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca gcctgggcac ccagacctac 600
atctgtaacg tgaaccacaa gcccagcaac accaaggtgg acaagaaggt ggagcccaag 660
agctgtgaca agacccacac ctgccccccc tgccctgccc ccgagctgct gggaggcccc 720
agcgtgttcc tgttcccccc caagcctaag gacaccctga tgatcagcag aacccccgag 780
gtgacctgtg tggtggtgga tgtgagccac gaggaccctg aggtgaagtt caactggtac 840
gtggacggcg tggaggtgca caatgccaag accaagccca gggaggagca gtacaacagc 900
acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg attggctgaa cggcaaggag 960
tacaagtgta aggtgtccaa caaggccctg cctgccccta tcgagaaaac catcagcaag 1020
gccaagggcc agcccagaga gccccaggtg tacaccctgc cccctagcag agatgagctg 1080
accaagaacc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc 1140
gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg 1200
gacagcgatg gcagcttctt cctgtacagc aagctgaccg tggacaagag cagatggcag 1260
cagggcaacg tgttcagctg ctccgtgatg cacgaggccc tgcacaatca ctacacccag 1320
aagagcctga gcctgtcccc tggcaag                                     1347

<210> SEQ ID NO:36
<211> LENGTH: 5
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: CDRH1 for YW311.31.57
      
      

<400> SEQ ID NO:36
Ser Tyr Tyr Ile Ser
 1               5  


<210> SEQ ID NO:37
<211> LENGTH: 17
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: CDRH2 for YW311.31.57
      
      

<400> SEQ ID NO:37
Glu Ile Ser Pro Tyr Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> SEQ ID NO:38
<211> LENGTH: 17
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: CDRH3 for YW311.31.57
      
      

<400> SEQ ID NO:38
Arg Ala Arg Pro Pro Ile Arg Leu Tyr Pro Arg Gly Ser Val Met Asp
 1               5                  10                  15      
Tyr
    


<210> SEQ ID NO:39
<211> LENGTH: 11
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: CDRL1 for YW311.31.57
      
      

<400> SEQ ID NO:39
Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala
 1               5                  10      


<210> SEQ ID NO:40
<211> LENGTH: 7
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: CDRL2 for YW311.31.57
      
      

<400> SEQ ID NO:40
Ser Ala Ser Phe Leu Tyr Ser
 1               5          


<210> SEQ ID NO:41
<211> LENGTH: 9
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: CDRL3 for YW311.31.57
      
      

<400> SEQ ID NO:41
Gln Gln Ser Tyr Thr Leu Pro Thr Thr
 1               5                  


<210> SEQ ID NO:42
<211> LENGTH: 126
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Heavy chain variable region of YW311.31.57
      
      

<400> SEQ ID NO:42
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Ser Pro Tyr Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Leu Arg Ala Arg Pro Pro Ile Arg Leu Tyr Pro Arg Gly Ser Val
            100                 105                 110         
Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125     


<210> SEQ ID NO:43
<211> LENGTH: 107
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Light chain variable region of YW311.31.57
      
      

<400> SEQ ID NO:43
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Leu Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> SEQ ID NO:44
<211> LENGTH: 456
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Heavy chain variable region of YW311.31.57
      
      

<400> SEQ ID NO:44
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Ser Pro Tyr Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Leu Arg Ala Arg Pro Pro Ile Arg Leu Tyr Pro Arg Gly Ser Val
            100                 105                 110         
Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser
        115                 120                 125             
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
    130                 135                 140                 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro
145                 150                 155                 160 
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val
                165                 170                 175     
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser
            180                 185                 190         
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile
        195                 200                 205             
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val
    210                 215                 220                 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
225                 230                 235                 240 
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
                245                 250                 255     
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
            260                 265                 270         
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
        275                 280                 285             
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
    290                 295                 300                 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
305                 310                 315                 320 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
                325                 330                 335     
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
            340                 345                 350         
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
        355                 360                 365             
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
    370                 375                 380                 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
385                 390                 395                 400 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
                405                 410                 415     
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
            420                 425                 430         
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
        435                 440                 445             
Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455     


<210> SEQ ID NO:45
<211> LENGTH: 1368
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Heavy chain  of YW311.31.57
      
      

<400> SEQ ID NO:45
gaggtgcagc tggtggagag cggcggaggc ctggtgcagc ccggcggcag cctcaggctg 60
agctgcgccg ccagcggctt caccttcacc agctactaca tcagctgggt cagacaggcc 120
cccggcaagg gactcgagtg ggtggccgag atcagcccct acagcggctc cacttactac 180
gccgacagcg tgaagggcag gttcaccatc agcgccgaca ccagcaagaa caccgcctac 240
ctgcaaatga actctctgag ggccgaggac actgccgtgt actactgcgc cctgagggct 300
aggcctccca tcaggctgta ccccaggggc agcgtgatgg actactgggg ccagggcaca 360
ctagtgaccg tgtccagcgc cagcaccaag ggccccagcg tgttccccct ggcccccagc 420
agcaagagca ccagcggcgg cacagccgcc ctgggctgcc tggtgaagga ctacttcccc 480
gaaccggtga ccgtgtcctg gaacagcgga gccctgacca gcggcgtgca caccttcccc 540
gccgtgctgc agagcagcgg cctgtacagc ctgagcagcg tggtgaccgt gcccagcagc 600
agcctgggca cccagaccta catctgtaac gtgaaccaca agcccagcaa caccaaggtg 660
gacaagaagg tggagcccaa gagctgtgac aagacccaca cctgcccccc ctgccctgcc 720
cccgagctgc tgggaggccc cagcgtgttc ctgttccccc ccaagcctaa ggacaccctg 780
atgatcagca gaacccccga ggtgacctgt gtggtggtgg atgtgagcca cgaggaccct 840
gaggtgaagt tcaactggta cgtggacggc gtggaggtgc acaatgccaa gaccaagccc 900
agggaggagc agtacaacag cacctaccgg gtggtgtccg tgctgaccgt gctgcaccag 960
gattggctga acggcaagga gtacaagtgt aaggtgtcca acaaggccct gcctgcccct 1020
atcgagaaaa ccatcagcaa ggccaagggc cagcccagag agccccaggt gtacaccctg 1080
ccccctagca gagatgagct gaccaagaac caggtgtccc tgacctgcct ggtgaagggc 1140
ttctacccca gcgacatcgc cgtggagtgg gagagcaacg gccagcccga gaacaactac 1200
aagaccaccc cccctgtgct ggacagcgat ggcagcttct tcctgtacag caagctgacc 1260
gtggacaaga gcagatggca gcagggcaac gtgttcagct gctccgtgat gcacgaggcc 1320
ctgcacaatc actacaccca gaagagcctg agcctgtccc ctggcaag              1368

<210> SEQ ID NO:46
<211> LENGTH: 214
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Light chain of YW311.31.57
      
      

<400> SEQ ID NO:46
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Leu Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> SEQ ID NO:47
<211> LENGTH: 5
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: CDRH1 for  YW311.31.62
      

<400> SEQ ID NO:47
Tyr Tyr Tyr Ile Ser
 1               5  


<210> SEQ ID NO:48
<211> LENGTH: 17
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: CDRH2 for  YW311.31.62
      

<400> SEQ ID NO:48
Glu Ile Ser Pro Tyr Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> SEQ ID NO:49
<211> LENGTH: 17
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: CDRH3 for  YW311.31.62
      

<400> SEQ ID NO:49
Arg Ala Arg Pro Pro Ile Arg Leu His Pro Arg Gly Ser Val Met Asp
 1               5                  10                  15      
Tyr
    


<210> SEQ ID NO:50
<211> LENGTH: 11
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: CDRL1 for  YW311.31.62
      

<400> SEQ ID NO:50
Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala
 1               5                  10      


<210> SEQ ID NO:51
<211> LENGTH: 7
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: CDRL2 for  YW311.31.62
      

<400> SEQ ID NO:51
Ser Ala Ser Phe Leu Tyr Ser
 1               5          


<210> SEQ ID NO:52
<211> LENGTH: 9
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: CDRL3 for  YW311.31.62
      

<400> SEQ ID NO:52
Gln Gln Ser Tyr Thr Thr Pro Pro Thr
 1               5                  


<210> SEQ ID NO:53
<211> LENGTH: 126
<212> TYPE: PRT
<213> ORGANISM:Heavy chain Variable region of YW311.31.62Artifici

<220> FEATURE:
<223> OTHER INFORMATION: Heavy chain Variable region of YW311.31.62
      

<400> SEQ ID NO:53
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Tyr Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Ser Pro Tyr Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Leu Arg Ala Arg Pro Pro Ile Arg Leu His Pro Arg Gly Ser Val
            100                 105                 110         
Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125     


<210> SEQ ID NO:54
<211> LENGTH: 107
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Light chain Variable region of YW311.31.62
      

<400> SEQ ID NO:54
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> SEQ ID NO:55
<211> LENGTH: 456
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Heavy Chain  of YW311.31.62
      

<400> SEQ ID NO:55
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Tyr Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Ser Pro Tyr Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Leu Arg Ala Arg Pro Pro Ile Arg Leu His Pro Arg Gly Ser Val
            100                 105                 110         
Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser
        115                 120                 125             
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
    130                 135                 140                 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro
145                 150                 155                 160 
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val
                165                 170                 175     
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser
            180                 185                 190         
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile
        195                 200                 205             
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val
    210                 215                 220                 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
225                 230                 235                 240 
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
                245                 250                 255     
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
            260                 265                 270         
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
        275                 280                 285             
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
    290                 295                 300                 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
305                 310                 315                 320 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
                325                 330                 335     
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
            340                 345                 350         
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
        355                 360                 365             
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
    370                 375                 380                 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
385                 390                 395                 400 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
                405                 410                 415     
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
            420                 425                 430         
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
        435                 440                 445             
Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455     


<210> SEQ ID NO:56
<211> LENGTH: 1368
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Heavy Chain  of YW311.31.62
      

<400> SEQ ID NO:56
gaggtgcagc tggtggagag cggcggaggc ctggtgcagc ccggcggcag cctcaggctg 60
agctgcgccg caagcggctt caccttcggc tactactaca tcagctgggt gaggcaggct 120
cccggcaagg gcctggagtg ggtggccgag atcagcccct acagcggcag cacctactac 180
gccgactccg tgaagggccg cttcaccatc agcgccgaca ccagcaagaa caccgcctac 240
ctgcaaatga actctctgag ggccgaggac accgccgtgt actattgcgc cctgagggcc 300
aggcctccca tcaggctgca ccccaggggc agcgtgatgg actactgggg ccagggcaca 360
ctagtgaccg tgtccagcgc cagcaccaag ggccccagcg tgttccccct ggcccccagc 420
agcaagagca ccagcggcgg cacagccgcc ctgggctgcc tggtgaagga ctacttcccc 480
gaaccggtga ccgtgtcctg gaacagcgga gccctgacca gcggcgtgca caccttcccc 540
gccgtgctgc agagcagcgg cctgtacagc ctgagcagcg tggtgaccgt gcccagcagc 600
agcctgggca cccagaccta catctgtaac gtgaaccaca agcccagcaa caccaaggtg 660
gacaagaagg tggagcccaa gagctgtgac aagacccaca cctgcccccc ctgccctgcc 720
cccgagctgc tgggaggccc cagcgtgttc ctgttccccc ccaagcctaa ggacaccctg 780
atgatcagca gaacccccga ggtgacctgt gtggtggtgg atgtgagcca cgaggaccct 840
gaggtgaagt tcaactggta cgtggacggc gtggaggtgc acaatgccaa gaccaagccc 900
agggaggagc agtacaacag cacctaccgg gtggtgtccg tgctgaccgt gctgcaccag 960
gattggctga acggcaagga gtacaagtgt aaggtgtcca acaaggccct gcctgcccct 1020
atcgagaaaa ccatcagcaa ggccaagggc cagcccagag agccccaggt gtacaccctg 1080
ccccctagca gagatgagct gaccaagaac caggtgtccc tgacctgcct ggtgaagggc 1140
ttctacccca gcgacatcgc cgtggagtgg gagagcaacg gccagcccga gaacaactac 1200
aagaccaccc cccctgtgct ggacagcgat ggcagcttct tcctgtacag caagctgacc 1260
gtggacaaga gcagatggca gcagggcaac gtgttcagct gctccgtgat gcacgaggcc 1320
ctgcacaatc actacaccca gaagagcctg agcctgtccc ctggcaag              1368

<210> SEQ ID NO:57
<211> LENGTH: 214
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Light Chain  of YW311.31.62
      

<400> SEQ ID NO:57
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> SEQ ID NO:58
<211> LENGTH: 642
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Light Chain  of YW311.31.62
      

<400> SEQ ID NO:58
gacatccaga tgacccagag ccccagcagc ctgagcgcaa gcgtcggaga cagggtgacc 60
attacctgca gggccagcca ggacgtgagc accgccgtgg cctggtatca gcagaaaccc 120
ggcaaggccc ccaagctgct gatctacagc gccagcttcc tgtacagcgg cgtgccctct 180
aggtttagcg gcagcggcag cggcactgac ttcaccctca ccatctccag cctgcagccc 240
gaggacttcg ccacctacta ctgccagcag agctacacca cccctcccac cttcggccag 300
ggcaccaagg tggagatcaa gcgtacggtg gccgccccca gcgtgttcat cttccccccc 360
agcgatgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac 420
ccccgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag 480
gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540
ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc 600
ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gc                    642

<210> SEQ ID NO:59
<211> LENGTH: 5
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: CDRH1 for  YW210.09
      

<400> SEQ ID NO:59
Asn Ser Tyr Ile His
 1               5  


<210> SEQ ID NO:60
<211> LENGTH: 17
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: CDRH2 for  YW210.09

<400> SEQ ID NO:60
Trp Ile Thr Pro Tyr Gly Gly Tyr Thr Asn Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> SEQ ID NO:61
<211> LENGTH: 17
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: CDRH3 for  YW210.09

<400> SEQ ID NO:61
Gly Ser Gly His Val Asn Ala Val Lys Asn Tyr Gly Tyr Val Met Asp
 1               5                  10                  15      
Tyr
    


<210> SEQ ID NO:62
<211> LENGTH: 11
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: CDRL1 for  YW210.09

<400> SEQ ID NO:62
Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala
 1               5                  10      


<210> SEQ ID NO:63
<211> LENGTH: 7
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: CDRL2 for  YW210.09

<400> SEQ ID NO:63
Ser Ala Ser Phe Leu Tyr Ser
 1               5          


<210> SEQ ID NO:64
<211> LENGTH: 9
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: CDRL3 for  YW210.09

<400> SEQ ID NO:64
Gln Gln Ser Tyr Thr Thr Pro Pro Thr
 1               5                  


<210> SEQ ID NO:65
<211> LENGTH: 126
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Heavy chain Variable region of YW210.09

<400> SEQ ID NO:65
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Ser
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Trp Ile Thr Pro Tyr Gly Gly Tyr Thr Asn Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Ser Gly His Val Asn Ala Val Lys Asn Tyr Gly Tyr Val
            100                 105                 110         
Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125     


<210> SEQ ID NO:66
<211> LENGTH: 107
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Light chain Variable region of YW210.09

<400> SEQ ID NO:66
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> SEQ ID NO:67
<211> LENGTH: 456
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Heavy chain of YW210.09

<400> SEQ ID NO:67
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Ser
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Trp Ile Thr Pro Tyr Gly Gly Tyr Thr Asn Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Ser Gly His Val Asn Ala Val Lys Asn Tyr Gly Tyr Val
            100                 105                 110         
Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser
        115                 120                 125             
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
    130                 135                 140                 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro
145                 150                 155                 160 
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val
                165                 170                 175     
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser
            180                 185                 190         
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile
        195                 200                 205             
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val
    210                 215                 220                 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
225                 230                 235                 240 
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
                245                 250                 255     
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
            260                 265                 270         
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
        275                 280                 285             
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
    290                 295                 300                 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
305                 310                 315                 320 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
                325                 330                 335     
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
            340                 345                 350         
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
        355                 360                 365             
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
    370                 375                 380                 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
385                 390                 395                 400 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
                405                 410                 415     
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
            420                 425                 430         
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
        435                 440                 445             
Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455     


<210> SEQ ID NO:68
<211> LENGTH: 1368
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Heavy chain of YW311.31.62

<400> SEQ ID NO:68
gaggtgcagc tggtggagag cggcggaggc ctggtgcagc ccggcggcag cctcaggctg 60
agctgcgccg ctagcggctt caccttcacc aacagctaca tccactgggt gaggcaggcc 120
cccggcaaag gactggagtg ggtgggctgg atcaccccct acggcggcta caccaactac 180
gccgacagcg tcaaggggag gttcaccatc agcgccgaca ccagcaagaa caccgcctac 240
ctgcaaatga actctctgag ggccgaggac actgccgtgt actattgcgc caggggctcc 300
ggccacgtga acgccgtgaa gaactacggc tacgtgatgg actactgggg ccagggcaca 360
ctagtgaccg tgtccagcgc cagcaccaag ggccccagcg tgttccccct ggcccccagc 420
agcaagagca ccagcggcgg cacagccgcc ctgggctgcc tggtgaagga ctacttcccc 480
gaaccggtga ccgtgtcctg gaacagcgga gccctgacca gcggcgtgca caccttcccc 540
gccgtgctgc agagcagcgg cctgtacagc ctgagcagcg tggtgaccgt gcccagcagc 600
agcctgggca cccagaccta catctgtaac gtgaaccaca agcccagcaa caccaaggtg 660
gacaagaagg tggagcccaa gagctgtgac aagacccaca cctgcccccc ctgccctgcc 720
cccgagctgc tgggaggccc cagcgtgttc ctgttccccc ccaagcctaa ggacaccctg 780
atgatcagca gaacccccga ggtgacctgt gtggtggtgg atgtgagcca cgaggaccct 840
gaggtgaagt tcaactggta cgtggacggc gtggaggtgc acaatgccaa gaccaagccc 900
agggaggagc agtacaacag cacctaccgg gtggtgtccg tgctgaccgt gctgcaccag 960
gattggctga acggcaagga gtacaagtgt aaggtgtcca acaaggccct gcctgcccct 1020
atcgagaaaa ccatcagcaa ggccaagggc cagcccagag agccccaggt gtacaccctg 1080
ccccctagca gagatgagct gaccaagaac caggtgtccc tgacctgcct ggtgaagggc 1140
ttctacccca gcgacatcgc cgtggagtgg gagagcaacg gccagcccga gaacaactac 1200
aagaccaccc cccctgtgct ggacagcgat ggcagcttct tcctgtacag caagctgacc 1260
gtggacaaga gcagatggca gcagggcaac gtgttcagct gctccgtgat gcacgaggcc 1320
ctgcacaatc actacaccca gaagagcctg agcctgtccc ctggcaag              1368

<210> SEQ ID NO:69
<211> LENGTH: 214
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Light chain of YW210.09

<400> SEQ ID NO:69
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> SEQ ID NO:70
<211> LENGTH: 642
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Light chain of YW311.31.62

<400> SEQ ID NO:70
gacatccaga tgacccagag ccccagcagc ctgagcgcaa gcgtcggaga cagggtgacc 60
attacctgca gggccagcca ggacgtgagc accgccgtgg cctggtatca gcagaaaccc 120
ggcaaggccc ccaagctgct gatctacagc gccagcttcc tgtacagcgg cgtgccctct 180
aggtttagcg gcagcggcag cggcactgac ttcaccctca ccatctccag cctgcagccc 240
gaggacttcg ccacctacta ctgccagcag agctacacca cccctcccac cttcggccag 300
ggcaccaagg tggagatcaa gcgtacggtg gccgccccca gcgtgttcat cttccccccc 360
agcgatgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac 420
ccccgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag 480
gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540
ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc 600
ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gc                    642

<210> SEQ ID NO:71
<211> LENGTH: 5
<212> TYPE: PRT
<213> ORGANISM:CDRH1 for Arca 135-16 and ARCA 135-16AArtificial S

<220> FEATURE:
<223> OTHER INFORMATION: CDRH1 for Arca 135-16 and ARCA 135-16A

<400> SEQ ID NO:71
Ser Tyr Pro Ile Glu
 1               5  


<210> SEQ ID NO:72
<211> LENGTH: 17
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: CDRH2 for Arca 135-16 and ARCA 135-16A

<400> SEQ ID NO:72
Asn Phe His Pro Tyr Asn Asp Asn Thr Lys Tyr Asn Glu Lys Phe Lys
 1               5                  10                  15      
Gly
    


<210> SEQ ID NO:73
<211> LENGTH: 12
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: CDRH3 for Arca 135-16 and ARCA 135-16A

<400> SEQ ID NO:73
Gly Tyr Ser Gly Asn Tyr Phe Ser Ala Met Asp Tyr
 1               5                  10          


<210> SEQ ID NO:74
<211> LENGTH: 11
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: CDRL1 for Arca 135-16 and ARCA 135-16A

<400> SEQ ID NO:74
Lys Ala Ser Gln Asn Val Arg Asn Asp Val Ala
 1               5                  10      


<210> SEQ ID NO:75
<211> LENGTH: 7
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: CDRL2 for Arca 135-16 and ARCA 135-16A

<400> SEQ ID NO:75
Leu Ala Ser Asn Arg His Thr
 1               5          


<210> SEQ ID NO:76
<211> LENGTH: 9
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: CDRL3 for Arca 135-16 and ARCA 135-16A

<400> SEQ ID NO:76
Leu Gln His Trp Asn Tyr Pro Tyr Thr
 1               5                  


<210> SEQ ID NO:77
<211> LENGTH: 121
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Heavy chain Variable region of Arca 135-16A

<400> SEQ ID NO:77
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Phe Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Pro Ile Glu Trp Met Lys Gln Asn His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asn Phe His Pro Tyr Asn Asp Asn Thr Lys Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Lys Leu Thr Val Glu Lys Ser Ser Ser Thr Val Tyr
65                  70                  75                  80  
Leu Glu Leu Ser Arg Ser Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Tyr Ser Gly Asn Tyr Phe Ser Ala Met Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     


<210> SEQ ID NO:78
<211> LENGTH: 363
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Heavy chain Variable region of Arca 135-16A

<400> SEQ ID NO:78
caggtgcagc tgcagcagag cggagccgaa ctggtgaagc ccggcgctag cgtgaagatg 60
agctgcaagg ccttcggcta caccttcacc agctacccca tcgagtggat gaagcagaac 120
cacggcaaga gcctggagtg gatcggcaat ttccacccct acaacgacaa caccaaatac 180
aacgagaagt tcaagggcaa ggccaagctg accgtggaga agagcagctc caccgtctat 240
ctggagctga gcaggagcac cagcgacgac agcgccgtgt actattgcgc cagggggtac 300
agcggcaact actttagcgc catggactac tggggccagg gaacactagt gaccgtgtcc 360
agc                                                               363

<210> SEQ ID NO:79
<211> LENGTH: 121
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Heavy chain Variable region of Arca 135-16

<400> SEQ ID NO:79
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Phe Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Pro Ile Glu Trp Met Lys Gln Asn His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asn Phe His Pro Tyr Asn Asp Asn Thr Lys Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Lys Leu Thr Val Glu Lys Ser Ser Ser Thr Val Tyr
65                  70                  75                  80  
Leu Glu Leu Ser Arg Ser Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Tyr Ser Gly Asn Tyr Phe Ser Ala Met Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Ser Val Thr Val Ser Ser
        115                 120     


<210> SEQ ID NO:80
<211> LENGTH: 363
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Heavy chain Variable region of Arca 135-16

<400> SEQ ID NO:80
caggtgcagc tgcagcagag cggagccgaa ctggtgaagc ccggcgctag cgtgaagatg 60
agctgcaagg ccttcggcta caccttcacc agctacccca tcgagtggat gaagcagaac 120
cacggcaaga gcctggagtg gatcggcaat ttccacccct acaacgacaa caccaaatac 180
aacgagaagt tcaagggcaa ggccaagctg accgtggaga agagcagctc caccgtctat 240
ctggagctga gcaggagcac cagcgacgac agcgccgtgt actattgcgc cagggggtac 300
agcggcaact actttagcgc catggactac tggggccagg gaacatcagt gaccgtgtcc 360
agc                                                               363

<210> SEQ ID NO:81
<211> LENGTH: 107
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Light chain Variable region of Arca 135-16

<400> SEQ ID NO:81
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Asn Asp
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ser Leu Ile
        35                  40                  45              
Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> SEQ ID NO:82
<211> LENGTH: 321
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Light chain Variable region of Arca 135-16A

<400> SEQ ID NO:82
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc 60
atcacctgca aggccagtca gaatgttcgt aatgatgtag cctggtatca acagaaacca 120
gggcagtctc ctaaatcact gatttacttg gcatccaacc ggcacactgg agtccctgat 180
cgcttcacag gcagtggatc tgggacagat ttcactctca ccattagcaa tgtgcaatct 240
gaagacctgg cagattattt ctgtctgcaa cattggaatt atccgtacac gttcggaggg 300
gggaccaagc tggaaataaa a                                           321

<210> SEQ ID NO:83
<211> LENGTH: 451
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Heavy chain Arca 135-16A

<400> SEQ ID NO:83
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Phe Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Pro Ile Glu Trp Met Lys Gln Asn His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asn Phe His Pro Tyr Asn Asp Asn Thr Lys Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Lys Leu Thr Val Glu Lys Ser Ser Ser Thr Val Tyr
65                  70                  75                  80  
Leu Glu Leu Ser Arg Ser Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Tyr Ser Gly Asn Tyr Phe Ser Ala Met Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445             
Pro Gly Lys
    450     


<210> SEQ ID NO:84
<211> LENGTH: 1353
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Heavy chain Arca 135-16A

<400> SEQ ID NO:84
caggtgcagc tgcagcagag cggagccgaa ctggtgaagc ccggcgctag cgtgaagatg 60
agctgcaagg ccttcggcta caccttcacc agctacccca tcgagtggat gaagcagaac 120
cacggcaaga gcctggagtg gatcggcaat ttccacccct acaacgacaa caccaaatac 180
aacgagaagt tcaagggcaa ggccaagctg accgtggaga agagcagctc caccgtctat 240
ctggagctga gcaggagcac cagcgacgac agcgccgtgt actattgcgc cagggggtac 300
agcggcaact actttagcgc catggactac tggggccagg gaacactagt gaccgtgtcc 360
agcgccagca ccaagggccc cagcgtgttc cccctggccc ccagcagcaa gagcaccagc 420
ggcggcacag ccgccctggg ctgcctggtg aaggactact tccccgaacc ggtgaccgtg 480
tcctggaaca gcggagccct gaccagcggc gtgcacacct tccccgccgt gctgcagagc 540
agcggcctgt acagcctgag cagcgtggtg accgtgccca gcagcagcct gggcacccag 600
acctacatct gtaacgtgaa ccacaagccc agcaacacca aggtggacaa gaaggtggag 660
cccaagagct gtgacaagac ccacacctgc cccccctgcc ctgcccccga gctgctggga 720
ggccccagcg tgttcctgtt cccccccaag cctaaggaca ccctgatgat cagcagaacc 780
cccgaggtga cctgtgtggt ggtggatgtg agccacgagg accctgaggt gaagttcaac 840
tggtacgtgg acggcgtgga ggtgcacaat gccaagacca agcccaggga ggagcagtac 900
aacagcacct accgggtggt gtccgtgctg accgtgctgc accaggattg gctgaacggc 960
aaggagtaca agtgtaaggt gtccaacaag gccctgcctg cccctatcga gaaaaccatc 1020
agcaaggcca agggccagcc cagagagccc caggtgtaca ccctgccccc tagcagagat 1080
gagctgacca agaaccaggt gtccctgacc tgcctggtga agggcttcta ccccagcgac 1140
atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac caccccccct 1200
gtgctggaca gcgatggcag cttcttcctg tacagcaagc tgaccgtgga caagagcaga 1260
tggcagcagg gcaacgtgtt cagctgctcc gtgatgcacg aggccctgca caatcactac 1320
acccagaaga gcctgagcct gtcccctggc aag                              1353

<210> SEQ ID NO:85
<211> LENGTH: 451
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Heavy chain Arca 135-16

<400> SEQ ID NO:85
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Phe Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Pro Ile Glu Trp Met Lys Gln Asn His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asn Phe His Pro Tyr Asn Asp Asn Thr Lys Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Lys Leu Thr Val Glu Lys Ser Ser Ser Thr Val Tyr
65                  70                  75                  80  
Leu Glu Leu Ser Arg Ser Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Tyr Ser Gly Asn Tyr Phe Ser Ala Met Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445             
Pro Gly Lys
    450     


<210> SEQ ID NO:86
<211> LENGTH: 1353
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Heavy chain of Arca 135-16

<400> SEQ ID NO:86
caggtgcagc tgcagcagag cggagccgaa ctggtgaagc ccggcgctag cgtgaagatg 60
agctgcaagg ccttcggcta caccttcacc agctacccca tcgagtggat gaagcagaac 120
cacggcaaga gcctggagtg gatcggcaat ttccacccct acaacgacaa caccaaatac 180
aacgagaagt tcaagggcaa ggccaagctg accgtggaga agagcagctc caccgtctat 240
ctggagctga gcaggagcac cagcgacgac agcgccgtgt actattgcgc cagggggtac 300
agcggcaact actttagcgc catggactac tggggccagg gaacatcagt gaccgtgtcc 360
agcgccagca ccaagggccc cagcgtgttc cccctggccc ccagcagcaa gagcaccagc 420
ggcggcacag ccgccctggg ctgcctggtg aaggactact tccccgaacc ggtgaccgtg 480
tcctggaaca gcggagccct gaccagcggc gtgcacacct tccccgccgt gctgcagagc 540
agcggcctgt acagcctgag cagcgtggtg accgtgccca gcagcagcct gggcacccag 600
acctacatct gtaacgtgaa ccacaagccc agcaacacca aggtggacaa gaaggtggag 660
cccaagagct gtgacaagac ccacacctgc cccccctgcc ctgcccccga gctgctggga 720
ggccccagcg tgttcctgtt cccccccaag cctaaggaca ccctgatgat cagcagaacc 780
cccgaggtga cctgtgtggt ggtggatgtg agccacgagg accctgaggt gaagttcaac 840
tggtacgtgg acggcgtgga ggtgcacaat gccaagacca agcccaggga ggagcagtac 900
aacagcacct accgggtggt gtccgtgctg accgtgctgc accaggattg gctgaacggc 960
aaggagtaca agtgtaaggt gtccaacaag gccctgcctg cccctatcga gaaaaccatc 1020
agcaaggcca agggccagcc cagagagccc caggtgtaca ccctgccccc tagcagagat 1080
gagctgacca agaaccaggt gtccctgacc tgcctggtga agggcttcta ccccagcgac 1140
atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac caccccccct 1200
gtgctggaca gcgatggcag cttcttcctg tacagcaagc tgaccgtgga caagagcaga 1260
tggcagcagg gcaacgtgtt cagctgctcc gtgatgcacg aggccctgca caatcactac 1320
acccagaaga gcctgagcct gtcccctggc aag                              1353

<210> SEQ ID NO:87
<211> LENGTH: 214
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Light chain of Arca 135-16

<400> SEQ ID NO:87
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Asn Asp
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ser Leu Ile
        35                  40                  45              
Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> SEQ ID NO:88
<211> LENGTH: 642
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Light chain of Arca 135-16

<400> SEQ ID NO:88
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc 60
atcacctgca aggccagtca gaatgttcgt aatgatgtag cctggtatca acagaaacca 120
gggcagtctc ctaaatcact gatttacttg gcatccaacc ggcacactgg agtccctgat 180
cgcttcacag gcagtggatc tgggacagat ttcactctca ccattagcaa tgtgcaatct 240
gaagacctgg cagattattt ctgtctgcaa cattggaatt atccgtacac gttcggaggg 300
gggaccaagc tggaaataaa acggacggtg gccgccccca gcgtgttcat cttccccccc 360
agcgatgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac 420
ccccgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag 480
gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540
ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc 600
ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gc                    642

<210> SEQ ID NO:90
<211> LENGTH: 351
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised variable heavy chain for DMS10064

<400> SEQ ID NO:90
cagctggtgc agagcggcgc cgaggtgaag aagcccggca gcagcgtgaa ggtgagctgc 60
aaggccagcg gctacacctt caccagctac tggatgcact gggtgaggca ggcccccggc 120
cagggcctgg agtggatggg caggatccac cccagcgaca gcgacaccaa ctacaaccag 180
aagttcaagg gcagggtgac catcaccgcc gacaagagca ccagcaccgc ctacatggag 240
ctgagcagcc tgaggagcga ggacaccgcc gtgtactact gcgccatcgg ctactactac 300
gacagcagct acgactactg gggccagggc acactagtga ccgtgtccag c          351

<210> SEQ ID NO:92
<211> LENGTH: 321
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised variable light chain

<400> SEQ ID NO:92
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc 60
atcacctgca gggccagcga gaacatctac agctacctgg cctggtacca gcagaagccc 120
ggcaaggccc ccaagctgct gatctacaac gccaagaccc tggccgaggg cgtgcccagc 180
aggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc 240
gaggacttcg ccacctacta ctgccagcac cactacggca cccccctgac cttcggccag 300
ggcaccaagc tggagatcaa g                                           321

<210> SEQ ID NO:93
<211> LENGTH: 119
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised variable heavy chain for DMS10079

<400> SEQ ID NO:93
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ile Gly Tyr Tyr Tyr Asp Ser Ser Tyr Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> SEQ ID NO:94
<211> LENGTH: 357
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised variable heavy chain for DMS10079

<400> SEQ ID NO:94
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcagcag cgtgaaggtg 60
agctgcaagg ccagcggcgg caccttcacc agctactgga tgcactgggt gaggcaggcc 120
cccggccagg gcctggagtg gatgggcagg atccacccca gcgacagcga caccaactac 180
aaccagaagt tcaagggcag ggtgaccatc accgccgaca agagcaccag caccgcctac 240
atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc catcggctac 300
tactacgaca gcagctacga ctactggggc cagggcacac tagtgaccgt gtccagc    357

<210> SEQ ID NO:95
<211> LENGTH: 119
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised variable heavy chain for DMS10080

<400> SEQ ID NO:95
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ile Gly Tyr Tyr Tyr Asp Ser Ser Tyr Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> SEQ ID NO:96
<211> LENGTH: 357
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised variable heavy chain for DMS10080

<400> SEQ ID NO:96
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcagcag cgtgaaggtg 60
agctgcaagg ccagcggcta caccttcagc agctactgga tgcactgggt gaggcaggcc 120
cccggccagg gcctggagtg gatgggcagg atccacccca gcgacagcga caccaactac 180
aaccagaagt tcaagggcag ggtgaccatc accgccgaca agagcaccag caccgcctac 240
atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc catcggctac 300
tactacgaca gcagctacga ctactggggc cagggcacac tagtgaccgt gtccagc    357

<210> SEQ ID NO:97
<211> LENGTH: 119
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised variable heavy chain for DMS10081

<400> SEQ ID NO:97
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Tyr Tyr Tyr Asp Ser Ser Tyr Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> SEQ ID NO:98
<211> LENGTH: 357
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised variable heavy chain for DMS10081

<400> SEQ ID NO:98
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcagcag cgtgaaggtg 60
agctgcaagg ccagcggcta caccttcacc agctactgga tgcactgggt gaggcaggcc 120
cccggccagg gcctggagtg gatgggcagg atccacccca gcgacagcga caccaactac 180
aaccagaagt tcaagggcag ggtgaccatc accgccgaca agagcaccag caccgcctac 240
atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caggggctac 300
tactacgaca gcagctacga ctactggggc cagggcacac tagtgaccgt gtccagc    357

<210> SEQ ID NO:99
<211> LENGTH: 119
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised variable heavy chain for DMS10082
      
      

<400> SEQ ID NO:99
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ile Gly Tyr Tyr Tyr Asp Ser Ser Tyr Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> SEQ ID NO:100
<211> LENGTH: 357
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised variable heavy chain for DMS10082
      
      

<400> SEQ ID NO:100
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcagcag cgtgaaggtg 60
agctgcaagg ccagcggcgg caccttcagc agctactgga tgcactgggt gaggcaggcc 120
cccggccagg gcctggagtg gatgggcagg atccacccca gcgacagcga caccaactac 180
aaccagaagt tcaagggcag ggtgaccatc accgccgaca agagcaccag caccgcctac 240
atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc catcggctac 300
tactacgaca gcagctacga ctactggggc cagggcacac tagtgaccgt gtccagc    357

<210> SEQ ID NO:101
<211> LENGTH: 119
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised variable heavy chain for DMS10083
      
      

<400> SEQ ID NO:101
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Tyr Tyr Tyr Asp Ser Ser Tyr Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> SEQ ID NO:102
<211> LENGTH: 357
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised variable heavy chain for DMS10083
      
      

<400> SEQ ID NO:102
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcagcag cgtgaaggtg 60
agctgcaagg ccagcggcta caccttcagc agctactgga tgcactgggt gaggcaggcc 120
cccggccagg gcctggagtg gatgggcagg atccacccca gcgacagcga caccaactac 180
aaccagaagt tcaagggcag ggtgaccatc accgccgaca agagcaccag caccgcctac 240
atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caggggctac 300
tactacgaca gcagctacga ctactggggc cagggcacac tagtgaccgt gtccagc    357

<210> SEQ ID NO:103
<211> LENGTH: 119
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised variable heavy chain for DMS10084
      
      

<400> SEQ ID NO:103
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Tyr Tyr Tyr Asp Ser Ser Tyr Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> SEQ ID NO:104
<211> LENGTH: 357
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised variable heavy chain for DMS10084
      
      

<400> SEQ ID NO:104
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcagcag cgtgaaggtg 60
agctgcaagg ccagcggcgg caccttcacc agctactgga tgcactgggt gaggcaggcc 120
cccggccagg gcctggagtg gatgggcagg atccacccca gcgacagcga caccaactac 180
aaccagaagt tcaagggcag ggtgaccatc accgccgaca agagcaccag caccgcctac 240
atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caggggctac 300
tactacgaca gcagctacga ctactggggc cagggcacac tagtgaccgt gtccagc    357

<210> SEQ ID NO:105
<211> LENGTH: 119
<212> TYPE: PRT
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised variable heavy chain for DMS10085
      
      

<400> SEQ ID NO:105
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Tyr Tyr Tyr Asp Ser Ser Tyr Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> SEQ ID NO:106
<211> LENGTH: 357
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Humanised variable heavy chain for DMS10085
      
      

<400> SEQ ID NO:106
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcagcag cgtgaaggtg 60
agctgcaagg ccagcggcgg caccttcagc agctactgga tgcactgggt gaggcaggcc 120
cccggccagg gcctggagtg gatgggcagg atccacccca gcgacagcga caccaactac 180
aaccagaagt tcaagggcag ggtgaccatc accgccgaca agagcaccag caccgcctac 240
atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caggggctac 300
tactacgaca gcagctacga ctactggggc cagggcacac tagtgaccgt gtccagc    357

<210> SEQ ID NO:107
<211> LENGTH: 642
<212> TYPE: DNA
<213> ORGANISM:Artificial Sequence

<220> FEATURE:
<223> OTHER INFORMATION: Light chain of YW311.31.57
      
      

<400> SEQ ID NO:107
gacatccaga tgacccagag ccccagcagc ctgagcgcaa gcgtcggaga cagggtgacc 60
attacctgca gggccagcca ggacgtgagc accgccgtgg cctggtatca gcagaaaccc 120
ggcaaggccc ccaagctgct gatctacagc gccagcttcc tgtacagcgg cgtgccctct 180
aggtttagcg gcagcggcag cggcactgac ttcaccctca ccatctccag cctgcagccc 240
gaggacttcg caacctacta ctgccagcag agctacaccc tgcccaccac ctttggccag 300
ggcaccaagg tggagatcaa gcgtacggtg gccgccccca gcgtgttcat cttccccccc 360
agcgatgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac 420
ccccgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag 480
gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540
ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc 600
ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gc                    642
