                         SEQUENCE LISTING

<110>  THE ROCKEFELLER UNIVERSITY
 
<120>  MicroRNAs that Suppress Human Melanoma

<130>  070413.20156

<140>  PCT/US13/54690
<141>  2013-08-13

<150>  61/784,057
<151>  2013-03-14

<150>  61/682,339
<151>  2012-08-13

<160>  141   

<170>  PatentIn version 3.5

<210>  1
<211>  1223
<212>  DNA
<213>  Homo sapiens

<400>  1
gggatccttg agtcctactc agccccagcg gaggtgaagg acgtccttcc ccaggagccg       60

actggccaat cacaggcagg aagatgaagg ttctgtgggc tgcgttgctg gtcacattcc      120

tggcaggatg ccaggccaag gtggagcaag cggtggagac agagccggag cccgagctgc      180

gccagcagac cgagtggcag agcggccagc gctgggaact ggcactgggt cgcttttggg      240

attacctgcg ctgggtgcag acactgtctg agcaggtgca ggaggagctg ctcagctccc      300

aggtcaccca ggaactgagg gcgctgatgg acgagaccat gaaggagttg aaggcctaca      360

aatcggaact ggaggaacaa ctgaccccgg tggcggagga gacgcgggca cggctgtcca      420

aggagctgca ggcggcgcag gcccggctgg gcgcggacat ggaggacgtg tgcggccgcc      480

tggtgcagta ccgcggcgag gtgcaggcca tgctcggcca gagcaccgag gagctgcggg      540

tgcgcctcgc ctcccacctg cgcaagctgc gtaagcggct cctccgcgat gccgatgacc      600

tgcagaagcg cctggcagtg taccaggccg gggcccgcga gggcgccgag cgcggcctca      660

gcgccatccg cgagcgcctg gggcccctgg tggaacaggg ccgcgtgcgg gccgccactg      720

tgggctccct ggccggccag ccgctacagg agcgggccca ggcctggggc gagcggctgc      780

gcgcgcggat ggaggagatg ggcagccgga cccgcgaccg cctggacgag gtgaaggagc      840

aggtggcgga ggtgcgcgcc aagctggagg agcaggccca gcagatacgc ctgcaggccg      900

aggccttcca ggcccgcctc aagagctggt tcgagcccct ggtggaagac atgcagcgcc      960

agtgggccgg gctggtggag aaggtgcagg ctgccgtggg caccagcgcc gcccctgtgc     1020

ccagcgacaa tcactgaacg ccgaagcctg cagccatgcg accccacgcc accccgtgcc     1080

tcctgcctcc gcgcagcctg cagcgggaga ccctgtcccc gccccagccg tcctcctggg     1140

gtggacccta gtttaataaa gattcaccaa gtttcacgca aaaaaaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaa                                             1223


<210>  2
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Val Leu Trp Ala Ala Leu Leu Val Thr Phe Leu Ala Gly Cys 
1               5                   10                  15      


Gln Ala Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu 
            20                  25                  30          


Arg Gln Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu 
        35                  40                  45              


Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln 
    50                  55                  60                  


Val Gln Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala 
65                  70                  75                  80  


Leu Met Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu 
                85                  90                  95      


Glu Glu Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser 
            100                 105                 110         


Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp 
        115                 120                 125             


Val Cys Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu 
    130                 135                 140                 


Gly Gln Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg 
145                 150                 155                 160 


Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg 
                165                 170                 175     


Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu 
            180                 185                 190         


Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val 
        195                 200                 205             


Arg Ala Ala Thr Val Gly Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg 
    210                 215                 220                 


Ala Gln Ala Trp Gly Glu Arg Leu Arg Ala Arg Met Glu Glu Met Gly 
225                 230                 235                 240 


Ser Arg Thr Arg Asp Arg Leu Asp Glu Val Lys Glu Gln Val Ala Glu 
                245                 250                 255     


Val Arg Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala 
            260                 265                 270         


Glu Ala Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu 
        275                 280                 285             


Asp Met Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala 
    290                 295                 300                 


Val Gly Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His 
305                 310                 315         


<210>  3
<211>  3203
<212>  RNA
<213>  Homo sapiens

<400>  3
agucccaccc uucggcgcag ggcuccggcc aacacagccc uccaggccgc cuacucucca       60

gccagccggc uccacggacc cacggaaggg caagggggcg gccucggggc ggcgggacag      120

uugucggagg gcgcccucca ggcccaagcc gccuucuccg gcccccgcca uggcccgggg      180

cggcagucag agcuggagcu ccggggaauc agacgggcag ccaaaggagc agacgcccga      240

gaagcccaga cacaagaugg ugaaggagac ccaguacuau gacauccugg gcgugaagcc      300

cagcgcgucc ccggaggaga ucaagaaggc cuaucggaag cuggcgcuca aguaccaccc      360

ggacaagaac ccggaugagg gcgagaaguu uaaacucaua ucccaggcau augaagugcu      420

uucagaucca aagaaaaggg auguuuauga ccaaggcgga gagcaggcaa uuaaagaagg      480

aggcucaggc agccccagcu ucucuucacc cauggacauc uuugacaugu ucuuuggugg      540

ugguggacgg auggcuagag agagaagagg caagaauguu guacaccagu uaucuguaac      600

ucuugaagau cuauauaaug gagucacgaa gaaauuggcc cuccagaaaa auguaauuug      660

ugagaaaugu gaagguguug gugggaagaa gggaucggug gagaagugcc cgcugugcaa      720

ggggcggggg augcagaucc acauccagca gaucgggccg ggcaugguac agcagaucca      780

gaccgugugc aucgagugca agggccaggg ugagcgcauc aaccccaagg accgcugcga      840

gagcugcagc ggggccaagg ugauccguga gaagaagauu aucgagguac auguugaaaa      900

agguaugaaa gaugggcaaa agauacuauu ucauggagaa ggagaucagg agccugagcu      960

ggagccuggu gaugucauaa uugugcuuga ucagaaggau cauagugucu uucagagacg     1020

aggccaugac uugaucauga aaaugaaaau ucagcuuucu gaagcucuuu guggcuucaa     1080

gaagacgaua aaaacauugg acaaucgaau ucuuguuauu acauccaaag caggugaggu     1140

gauaaagcac ggggaccuga gaugcgugcg cgaugaagga augcccaucu acaaagcacc     1200

ccuggaaaaa gggauucuga ucauacaguu uuuaguaauc uuuccugaaa aacacuggcu     1260

uucucuggaa aagcuuccuc agcuggaagc uuuacucccu ccucgacaga aagugaggau     1320

uacagaugac auggaucagg uggagcugaa ggaguuuugu cccaaugagc agaacuggcg     1380

ucagcacagg gaggccuacg aggaggacga agacgggccc caggcuggag ugcagugcca     1440

gacggcauga cguggugcgg ggcagcgugg ccccaccgga cuagcacaug augaauguaa     1500

aguuggcaca augaaaauga caucgcuuua auggccuugu guuugggaug uccuguguau     1560

guguucagca uucuuaauug cugagugucu uuuuggcuuu ucuuuugguu guaacuuaag     1620

uuauagcuua auuuauauuu aaauguuuua aguauaaauc accucuaguc ugcauaugga     1680

aucuguucau uucuauuuuc aggauauacu uuugagaugu cagugauugc accaauacuu     1740

ugugcuucua guggcuuugc cauaauucag ugucaccaau aaggcacagc ccaguuagca     1800

gcuuagcccc ccuagcaaac cccaaggcac aaagugggca uccugacuca ucucuagguc     1860

ugugguuucu ccccucuucc cuuggcagag uuauugaggg caugaucuca gggcugcuaa     1920

gauaacauuu cugaggauuc uagaugaucc ucuuaaagaa uaaaagcaca uccguggauc     1980

ggacauggcu gcaugugccu gcuuaacagg gccaacuuag uuccuacugu ucugugcccu     2040

ucaguggaug gaacgugagu gucugaucau cucucuugga aguuuucuga accuuccaag     2100

cucuguggug aggacaaacc aguguuugaa ucauaugcug auaacuguuu gccugugacc     2160

cucacaccuu guucuucagg guuuuaauga uuuucuguug acaacuuuug caaugcuuuc     2220

ccaccaaagu gcuuacuugu aaagaaaacu aaauccuucu guguccccgg cagccucagu     2280

gcagcaacag aagccaaggg agaaugcugc ugguuuggcc cauggcacag ccagcuucuc     2340

ugaccaguaa uccgggguga cuugaggguc ugcaaaggca uagaacuccc caguguuuuc     2400

caccucauuc ucccagauug agcucccuuc caaaggaucg uuccucucau ugcacagcca     2460

uauuacaaag gguuuccugc ucaagugaug uuuugguaag aacuucgcug aguuccacug     2520

uggauuacag uuuguaugga cuacuacugu aaauuauagc uuguuuggag ggauauuagu     2580

cauuauuuua uucaugacag guagacuaca auucgaacuu aggguuaccu cagucuuuag     2640

ccauuacugc uuauuucuuu uccccaaguc acaaaaaacu uguaagcugc uggguuaaag     2700

cagaggccac cugucagauc uacccuaccc uuauuugguu acauggcacc ugagaguuuc     2760

acucagacca gggaucuucc uuaggagggu caaagugcag aucagaccau gcagguaagg     2820

ugaaccagcu gcacggacca gguucccgca aaacauugcc agcuagugag gcauaauuug     2880

cucaaaguau agaaacagcc caccugugcc cacuuugacc auuggugagg auagauauaa     2940

aaucacuucu uccaacgaag ccuaggugaa aaucuauuua uaaauggacc acaacucugg     3000

ggugucguuu uugugcugug acuuccuaau uauugcuaaa gaacuacugu uuaguuggua     3060

augguguaaa auuacauuca gcuccuucuu gucauauaaa aggaauuugg agggugucgc     3120

uuaaaauuuu auuccaccug uacauuuguc acuuuaaaau uaaaauugag cugguaugag     3180

agauaaaaaa aaaaaaaaaa aaa                                             3203


<210>  4
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Arg Gly Gly Ser Gln Ser Trp Ser Ser Gly Glu Ser Asp Gly 
1               5                   10                  15      


Gln Pro Lys Glu Gln Thr Pro Glu Lys Pro Arg His Lys Met Val Lys 
            20                  25                  30          


Glu Thr Gln Tyr Tyr Asp Ile Leu Gly Val Lys Pro Ser Ala Ser Pro 
        35                  40                  45              


Glu Glu Ile Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys Tyr His Pro 
    50                  55                  60                  


Asp Lys Asn Pro Asp Glu Gly Glu Lys Phe Lys Leu Ile Ser Gln Ala 
65                  70                  75                  80  


Tyr Glu Val Leu Ser Asp Pro Lys Lys Arg Asp Val Tyr Asp Gln Gly 
                85                  90                  95      


Gly Glu Gln Ala Ile Lys Glu Gly Gly Ser Gly Ser Pro Ser Phe Ser 
            100                 105                 110         


Ser Pro Met Asp Ile Phe Asp Met Phe Phe Gly Gly Gly Gly Arg Met 
        115                 120                 125             


Ala Arg Glu Arg Arg Gly Lys Asn Val Val His Gln Leu Ser Val Thr 
    130                 135                 140                 


Leu Glu Asp Leu Tyr Asn Gly Val Thr Lys Lys Leu Ala Leu Gln Lys 
145                 150                 155                 160 


Asn Val Ile Cys Glu Lys Cys Glu Gly Val Gly Gly Lys Lys Gly Ser 
                165                 170                 175     


Val Glu Lys Cys Pro Leu Cys Lys Gly Arg Gly Met Gln Ile His Ile 
            180                 185                 190         


Gln Gln Ile Gly Pro Gly Met Val Gln Gln Ile Gln Thr Val Cys Ile 
        195                 200                 205             


Glu Cys Lys Gly Gln Gly Glu Arg Ile Asn Pro Lys Asp Arg Cys Glu 
    210                 215                 220                 


Ser Cys Ser Gly Ala Lys Val Ile Arg Glu Lys Lys Ile Ile Glu Val 
225                 230                 235                 240 


His Val Glu Lys Gly Met Lys Asp Gly Gln Lys Ile Leu Phe His Gly 
                245                 250                 255     


Glu Gly Asp Gln Glu Pro Glu Leu Glu Pro Gly Asp Val Ile Ile Val 
            260                 265                 270         


Leu Asp Gln Lys Asp His Ser Val Phe Gln Arg Arg Gly His Asp Leu 
        275                 280                 285             


Ile Met Lys Met Lys Ile Gln Leu Ser Glu Ala Leu Cys Gly Phe Lys 
    290                 295                 300                 


Lys Thr Ile Lys Thr Leu Asp Asn Arg Ile Leu Val Ile Thr Ser Lys 
305                 310                 315                 320 


Ala Gly Glu Val Ile Lys His Gly Asp Leu Arg Cys Val Arg Asp Glu 
                325                 330                 335     


Gly Met Pro Ile Tyr Lys Ala Pro Leu Glu Lys Gly Ile Leu Ile Ile 
            340                 345                 350         


Gln Phe Leu Val Ile Phe Pro Glu Lys His Trp Leu Ser Leu Glu Lys 
        355                 360                 365             


Leu Pro Gln Leu Glu Ala Leu Leu Pro Pro Arg Gln Lys Val Arg Ile 
    370                 375                 380                 


Thr Asp Asp Met Asp Gln Val Glu Leu Lys Glu Phe Cys Pro Asn Glu 
385                 390                 395                 400 


Gln Asn Trp Arg Gln His Arg Glu Ala Tyr Glu Glu Asp Glu Asp Gly 
                405                 410                 415     


Pro Gln Ala Gly Val Gln Cys Gln Thr Ala 
            420                 425     


<210>  5
<211>  3064
<212>  RNA
<213>  Homo sapiens

<400>  5
gugaccguga cgcgcgagcg ggcggcgggg gcgcgggcca ggggcgcggg ccagggugcc       60

ggcaggggcg uccggggcgc ucugaccggc cucgcccgcc ccccccgcag acacaagaug      120

gugaaggaga cccaguacua ugacauccug ggcgugaagc ccagcgcguc cccggaggag      180

aucaagaagg ccuaucggaa gcuggcgcuc aaguaccacc cggacaagaa cccggaugag      240

ggcgagaagu uuaaacucau aucccaggca uaugaagugc uuucagaucc aaagaaaagg      300

gauguuuaug accaaggcgg agagcaggca auuaaagaag gaggcucagg cagccccagc      360

uucucuucac ccauggacau cuuugacaug uucuuuggug gugguggacg gauggcuaga      420

gagagaagag gcaagaaugu uguacaccag uuaucuguaa cucuugaaga ucuauauaau      480

ggagucacga agaaauuggc ccuccagaaa aauguaauuu gugagaaaug ugaagguguu      540

ggugggaaga agggaucggu ggagaagugc ccgcugugca aggggcgggg gaugcagauc      600

cacauccagc agaucgggcc gggcauggua cagcagaucc agaccgugug caucgagugc      660

aagggccagg gugagcgcau caaccccaag gaccgcugcg agagcugcag cggggccaag      720

gugauccgug agaagaagau uaucgaggua cauguugaaa aagguaugaa agaugggcaa      780

aagauacuau uucauggaga aggagaucag gagccugagc uggagccugg ugaugucaua      840

auugugcuug aucagaagga ucauaguguc uuucagagac gaggccauga cuugaucaug      900

aaaaugaaaa uucagcuuuc ugaagcucuu uguggcuuca agaagacgau aaaaacauug      960

gacaaucgaa uucuuguuau uacauccaaa gcaggugagg ugauaaagca cggggaccug     1020

agaugcgugc gcgaugaagg aaugcccauc uacaaagcac cccuggaaaa agggauucug     1080

aucauacagu uuuuaguaau cuuuccugaa aaacacuggc uuucucugga aaagcuuccu     1140

cagcuggaag cuuuacuccc uccucgacag aaagugagga uuacagauga cauggaucag     1200

guggagcuga aggaguuuug ucccaaugag cagaacuggc gucagcacag ggaggccuac     1260

gaggaggacg aagacgggcc ccaggcugga gugcagugcc agacggcaug acguggugcg     1320

gggcagcgug gccccaccgg acuagcacau gaugaaugua aaguuggcac aaugaaaaug     1380

acaucgcuuu aauggccuug uguuugggau guccugugua uguguucagc auucuuaauu     1440

gcugaguguc uuuuuggcuu uucuuuuggu uguaacuuaa guuauagcuu aauuuauauu     1500

uaaauguuuu aaguauaaau caccucuagu cugcauaugg aaucuguuca uuucuauuuu     1560

caggauauac uuuugagaug ucagugauug caccaauacu uugugcuucu aguggcuuug     1620

ccauaauuca gugucaccaa uaaggcacag cccaguuagc agcuuagccc cccuagcaaa     1680

ccccaaggca caaagugggc auccugacuc aucucuaggu cugugguuuc uccccucuuc     1740

ccuuggcaga guuauugagg gcaugaucuc agggcugcua agauaacauu ucugaggauu     1800

cuagaugauc cucuuaaaga auaaaagcac auccguggau cggacauggc ugcaugugcc     1860

ugcuuaacag ggccaacuua guuccuacug uucugugccc uucaguggau ggaacgugag     1920

ugucugauca ucucucuugg aaguuuucug aaccuuccaa gcucuguggu gaggacaaac     1980

caguguuuga aucauaugcu gauaacuguu ugccugugac ccucacaccu uguucuucag     2040

gguuuuaaug auuuucuguu gacaacuuuu gcaaugcuuu cccaccaaag ugcuuacuug     2100

uaaagaaaac uaaauccuuc uguguccccg gcagccucag ugcagcaaca gaagccaagg     2160

gagaaugcug cugguuuggc ccauggcaca gccagcuucu cugaccagua auccggggug     2220

acuugagggu cugcaaaggc auagaacucc ccaguguuuu ccaccucauu cucccagauu     2280

gagcucccuu ccaaaggauc guuccucuca uugcacagcc auauuacaaa ggguuuccug     2340

cucaagugau guuuugguaa gaacuucgcu gaguuccacu guggauuaca guuuguaugg     2400

acuacuacug uaaauuauag cuuguuugga gggauauuag ucauuauuuu auucaugaca     2460

gguagacuac aauucgaacu uaggguuacc ucagucuuua gccauuacug cuuauuucuu     2520

uuccccaagu cacaaaaaac uuguaagcug cuggguuaaa gcagaggcca ccugucagau     2580

cuacccuacc cuuauuuggu uacauggcac cugagaguuu cacucagacc agggaucuuc     2640

cuuaggaggg ucaaagugca gaucagacca ugcagguaag gugaaccagc ugcacggacc     2700

agguucccgc aaaacauugc cagcuaguga ggcauaauuu gcucaaagua uagaaacagc     2760

ccaccugugc ccacuuugac cauuggugag gauagauaua aaaucacuuc uuccaacgaa     2820

gccuagguga aaaucuauuu auaaauggac cacaacucug gggugucguu uuugugcugu     2880

gacuuccuaa uuauugcuaa agaacuacug uuuaguuggu aaugguguaa aauuacauuc     2940

agcuccuucu ugucauauaa aaggaauuug gagggugucg cuuaaaauuu uauuccaccu     3000

guacauuugu cacuuuaaaa uuaaaauuga gcugguauga gagauaaaaa aaaaaaaaaa     3060

aaaa                                                                  3064


<210>  6
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Val Lys Glu Thr Gln Tyr Tyr Asp Ile Leu Gly Val Lys Pro Ser 
1               5                   10                  15      


Ala Ser Pro Glu Glu Ile Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys 
            20                  25                  30          


Tyr His Pro Asp Lys Asn Pro Asp Glu Gly Glu Lys Phe Lys Leu Ile 
        35                  40                  45              


Ser Gln Ala Tyr Glu Val Leu Ser Asp Pro Lys Lys Arg Asp Val Tyr 
    50                  55                  60                  


Asp Gln Gly Gly Glu Gln Ala Ile Lys Glu Gly Gly Ser Gly Ser Pro 
65                  70                  75                  80  


Ser Phe Ser Ser Pro Met Asp Ile Phe Asp Met Phe Phe Gly Gly Gly 
                85                  90                  95      


Gly Arg Met Ala Arg Glu Arg Arg Gly Lys Asn Val Val His Gln Leu 
            100                 105                 110         


Ser Val Thr Leu Glu Asp Leu Tyr Asn Gly Val Thr Lys Lys Leu Ala 
        115                 120                 125             


Leu Gln Lys Asn Val Ile Cys Glu Lys Cys Glu Gly Val Gly Gly Lys 
    130                 135                 140                 


Lys Gly Ser Val Glu Lys Cys Pro Leu Cys Lys Gly Arg Gly Met Gln 
145                 150                 155                 160 


Ile His Ile Gln Gln Ile Gly Pro Gly Met Val Gln Gln Ile Gln Thr 
                165                 170                 175     


Val Cys Ile Glu Cys Lys Gly Gln Gly Glu Arg Ile Asn Pro Lys Asp 
            180                 185                 190         


Arg Cys Glu Ser Cys Ser Gly Ala Lys Val Ile Arg Glu Lys Lys Ile 
        195                 200                 205             


Ile Glu Val His Val Glu Lys Gly Met Lys Asp Gly Gln Lys Ile Leu 
    210                 215                 220                 


Phe His Gly Glu Gly Asp Gln Glu Pro Glu Leu Glu Pro Gly Asp Val 
225                 230                 235                 240 


Ile Ile Val Leu Asp Gln Lys Asp His Ser Val Phe Gln Arg Arg Gly 
                245                 250                 255     


His Asp Leu Ile Met Lys Met Lys Ile Gln Leu Ser Glu Ala Leu Cys 
            260                 265                 270         


Gly Phe Lys Lys Thr Ile Lys Thr Leu Asp Asn Arg Ile Leu Val Ile 
        275                 280                 285             


Thr Ser Lys Ala Gly Glu Val Ile Lys His Gly Asp Leu Arg Cys Val 
    290                 295                 300                 


Arg Asp Glu Gly Met Pro Ile Tyr Lys Ala Pro Leu Glu Lys Gly Ile 
305                 310                 315                 320 


Leu Ile Ile Gln Phe Leu Val Ile Phe Pro Glu Lys His Trp Leu Ser 
                325                 330                 335     


Leu Glu Lys Leu Pro Gln Leu Glu Ala Leu Leu Pro Pro Arg Gln Lys 
            340                 345                 350         


Val Arg Ile Thr Asp Asp Met Asp Gln Val Glu Leu Lys Glu Phe Cys 
        355                 360                 365             


Pro Asn Glu Gln Asn Trp Arg Gln His Arg Glu Ala Tyr Glu Glu Asp 
    370                 375                 380                 


Glu Asp Gly Pro Gln Ala Gly Val Gln Cys Gln Thr Ala 
385                 390                 395         


<210>  7
<211>  2891
<212>  RNA
<213>  Homo sapiens

<400>  7
acauuucagc aagcuggcua aagacaugug ggaaagccug acccuggauu caggucaaau       60

cucagcacuc acaagauuua aacucauauc ccaggcauau gaagugcuuu cagauccaaa      120

gaaaagggau guuuaugacc aaggcggaga gcaggcaauu aaagaaggag gcucaggcag      180

ccccagcuuc ucuucaccca uggacaucuu ugacauguuc uuugguggug guggacggau      240

ggcuagagag agaagaggca agaauguugu acaccaguua ucuguaacuc uugaagaucu      300

auauaaugga gucacgaaga aauuggcccu ccagaaaaau guaauuugug agaaauguga      360

agguguuggu gggaagaagg gaucggugga gaagugcccg cugugcaagg ggcgggggau      420

gcagauccac auccagcaga ucgggccggg caugguacag cagauccaga ccgugugcau      480

cgagugcaag ggccagggug agcgcaucaa ccccaaggac cgcugcgaga gcugcagcgg      540

ggccaaggug auccgugaga agaagauuau cgagguacau guugaaaaag guaugaaaga      600

ugggcaaaag auacuauuuc auggagaagg agaucaggag ccugagcugg agccugguga      660

ugucauaauu gugcuugauc agaaggauca uagugucuuu cagagacgag gccaugacuu      720

gaucaugaaa augaaaauuc agcuuucuga agcucuuugu ggcuucaaga agacgauaaa      780

aacauuggac aaucgaauuc uuguuauuac auccaaagca ggugagguga uaaagcacgg      840

ggaccugaga ugcgugcgcg augaaggaau gcccaucuac aaagcacccc uggaaaaagg      900

gauucugauc auacaguuuu uaguaaucuu uccugaaaaa cacuggcuuu cucuggaaaa      960

gcuuccucag cuggaagcuu uacucccucc ucgacagaaa gugaggauua cagaugacau     1020

ggaucaggug gagcugaagg aguuuugucc caaugagcag aacuggcguc agcacaggga     1080

ggccuacgag gaggacgaag acgggcccca ggcuggagug cagugccaga cggcaugacg     1140

uggugcgggg cagcguggcc ccaccggacu agcacaugau gaauguaaag uuggcacaau     1200

gaaaaugaca ucgcuuuaau ggccuugugu uugggauguc cuguguaugu guucagcauu     1260

cuuaauugcu gagugucuuu uuggcuuuuc uuuugguugu aacuuaaguu auagcuuaau     1320

uuauauuuaa auguuuuaag uauaaaucac cucuagucug cauauggaau cuguucauuu     1380

cuauuuucag gauauacuuu ugagauguca gugauugcac caauacuuug ugcuucuagu     1440

ggcuuugcca uaauucagug ucaccaauaa ggcacagccc aguuagcagc uuagcccccc     1500

uagcaaaccc caaggcacaa agugggcauc cugacucauc ucuaggucug ugguuucucc     1560

ccucuucccu uggcagaguu auugagggca ugaucucagg gcugcuaaga uaacauuucu     1620

gaggauucua gaugauccuc uuaaagaaua aaagcacauc cguggaucgg acauggcugc     1680

augugccugc uuaacagggc caacuuaguu ccuacuguuc ugugcccuuc aguggaugga     1740

acgugagugu cugaucaucu cucuuggaag uuuucugaac cuuccaagcu cuguggugag     1800

gacaaaccag uguuugaauc auaugcugau aacuguuugc cugugacccu cacaccuugu     1860

ucuucagggu uuuaaugauu uucuguugac aacuuuugca augcuuuccc accaaagugc     1920

uuacuuguaa agaaaacuaa auccuucugu guccccggca gccucagugc agcaacagaa     1980

gccaagggag aaugcugcug guuuggccca uggcacagcc agcuucucug accaguaauc     2040

cggggugacu ugagggucug caaaggcaua gaacucccca guguuuucca ccucauucuc     2100

ccagauugag cucccuucca aaggaucguu ccucucauug cacagccaua uuacaaaggg     2160

uuuccugcuc aagugauguu uugguaagaa cuucgcugag uuccacugug gauuacaguu     2220

uguauggacu acuacuguaa auuauagcuu guuuggaggg auauuaguca uuauuuuauu     2280

caugacaggu agacuacaau ucgaacuuag gguuaccuca gucuuuagcc auuacugcuu     2340

auuucuuuuc cccaagucac aaaaaacuug uaagcugcug gguuaaagca gaggccaccu     2400

gucagaucua cccuacccuu auuugguuac auggcaccug agaguuucac ucagaccagg     2460

gaucuuccuu aggaggguca aagugcagau cagaccaugc agguaaggug aaccagcugc     2520

acggaccagg uucccgcaaa acauugccag cuagugaggc auaauuugcu caaaguauag     2580

aaacagccca ccugugccca cuuugaccau uggugaggau agauauaaaa ucacuucuuc     2640

caacgaagcc uaggugaaaa ucuauuuaua aauggaccac aacucugggg ugucguuuuu     2700

gugcugugac uuccuaauua uugcuaaaga acuacuguuu aguugguaau gguguaaaau     2760

uacauucagc uccuucuugu cauauaaaag gaauuuggag ggugucgcuu aaaauuuuau     2820

uccaccugua cauuugucac uuuaaaauua aaauugagcu gguaugagag auaaaaaaaa     2880

aaaaaaaaaa a                                                          2891


<210>  8
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Trp Glu Ser Leu Thr Leu Asp Ser Gly Gln Ile Ser Ala Leu Thr 
1               5                   10                  15      


Arg Phe Lys Leu Ile Ser Gln Ala Tyr Glu Val Leu Ser Asp Pro Lys 
            20                  25                  30          


Lys Arg Asp Val Tyr Asp Gln Gly Gly Glu Gln Ala Ile Lys Glu Gly 
        35                  40                  45              


Gly Ser Gly Ser Pro Ser Phe Ser Ser Pro Met Asp Ile Phe Asp Met 
    50                  55                  60                  


Phe Phe Gly Gly Gly Gly Arg Met Ala Arg Glu Arg Arg Gly Lys Asn 
65                  70                  75                  80  


Val Val His Gln Leu Ser Val Thr Leu Glu Asp Leu Tyr Asn Gly Val 
                85                  90                  95      


Thr Lys Lys Leu Ala Leu Gln Lys Asn Val Ile Cys Glu Lys Cys Glu 
            100                 105                 110         


Gly Val Gly Gly Lys Lys Gly Ser Val Glu Lys Cys Pro Leu Cys Lys 
        115                 120                 125             


Gly Arg Gly Met Gln Ile His Ile Gln Gln Ile Gly Pro Gly Met Val 
    130                 135                 140                 


Gln Gln Ile Gln Thr Val Cys Ile Glu Cys Lys Gly Gln Gly Glu Arg 
145                 150                 155                 160 


Ile Asn Pro Lys Asp Arg Cys Glu Ser Cys Ser Gly Ala Lys Val Ile 
                165                 170                 175     


Arg Glu Lys Lys Ile Ile Glu Val His Val Glu Lys Gly Met Lys Asp 
            180                 185                 190         


Gly Gln Lys Ile Leu Phe His Gly Glu Gly Asp Gln Glu Pro Glu Leu 
        195                 200                 205             


Glu Pro Gly Asp Val Ile Ile Val Leu Asp Gln Lys Asp His Ser Val 
    210                 215                 220                 


Phe Gln Arg Arg Gly His Asp Leu Ile Met Lys Met Lys Ile Gln Leu 
225                 230                 235                 240 


Ser Glu Ala Leu Cys Gly Phe Lys Lys Thr Ile Lys Thr Leu Asp Asn 
                245                 250                 255     


Arg Ile Leu Val Ile Thr Ser Lys Ala Gly Glu Val Ile Lys His Gly 
            260                 265                 270         


Asp Leu Arg Cys Val Arg Asp Glu Gly Met Pro Ile Tyr Lys Ala Pro 
        275                 280                 285             


Leu Glu Lys Gly Ile Leu Ile Ile Gln Phe Leu Val Ile Phe Pro Glu 
    290                 295                 300                 


Lys His Trp Leu Ser Leu Glu Lys Leu Pro Gln Leu Glu Ala Leu Leu 
305                 310                 315                 320 


Pro Pro Arg Gln Lys Val Arg Ile Thr Asp Asp Met Asp Gln Val Glu 
                325                 330                 335     


Leu Lys Glu Phe Cys Pro Asn Glu Gln Asn Trp Arg Gln His Arg Glu 
            340                 345                 350         


Ala Tyr Glu Glu Asp Glu Asp Gly Pro Gln Ala Gly Val Gln Cys Gln 
        355                 360                 365             


Thr Ala 
    370 


<210>  9
<211>  14905
<212>  RNA
<213>  Homo sapiens

<400>  9
cagcggugcg agcuccaggc ccaugcacug aggaggcgga aacaagggga gcccccagag       60

cuccaucaag cccccuccaa aggcuccccu acccggucca cgccccccac ccccccuccc      120

cgccuccucc caauugugca uuuuugcagc cggaggcggc uccgagaugg ggcugugagc      180

uucgcccggg gagggggaaa gagcagcgag gagugaagcg gggggguggg gugaaggguu      240

uggauuucgg ggcagggggc gcacccccgu cagcaggccc uccccaaggg gcucggaacu      300

cuaccucuuc acccacgccc cuggugcgcu uugccgaagg aaagaauaag aacagagaag      360

gaggaggggg aaaggaggaa aagggggacc ccccaacugg ggggggugaa ggagagaagu      420

agcaggacca gaggggaagg ggcugcugcu ugcaucagcc cacaccaugc ugaccccgcc      480

guugcuccug cugcugcccc ugcucucagc ucuggucgcg gcggcuaucg acgccccuaa      540

gacuugcagc cccaagcagu uugccugcag agaucaaaua accuguaucu caaagggcug      600

gcggugcgac ggugagaggg acugcccaga cggaucugac gaggccccug agauuugucc      660

acagaguaag gcccagcgau gccagccaaa cgagcauaac ugccugggua cugagcugug      720

uguucccaug ucccgccucu gcaauggggu ccaggacugc auggacggcu cagaugaggg      780

gccccacugc cgagagcucc aaggcaacug cucucgccug ggcugccagc accauugugu      840

ccccacacuc gaugggccca ccugcuacug caacagcagc uuucagcuuc aggcagaugg      900

caagaccugc aaagauuuug augagugcuc aguguacggc accugcagcc agcuaugcac      960

caacacagac ggcuccuuca uauguggcug uguugaagga uaccuccugc agccggauaa     1020

ccgcuccugc aaggccaaga acgagccagu agaccggccc ccugugcugu ugauagccaa     1080

cucccagaac aucuuggcca cguaccugag uggggcccag gugucuacca ucacaccuac     1140

gagcacgcgg cagaccacag ccauggacuu cagcuaugcc aacgagaccg uaugcugggu     1200

gcauguuggg gacagugcug cucagacgca gcucaagugu gcccgcaugc cuggccuaaa     1260

gggcuucgug gaugagcaca ccaucaacau cucccucagu cugcaccacg uggaacagau     1320

ggccaucgac uggcugacag gcaacuucua cuuuguggau gacaucgaug auaggaucuu     1380

ugucugcaac agaaaugggg acacaugugu cacauugcua gaccuggaac ucuacaaccc     1440

caagggcauu gcccuggacc cugccauggg gaagguguuu uucacugacu augggcagau     1500

cccaaaggug gaacgcugug acauggaugg gcagaaccgc accaagcucg ucgacagcaa     1560

gauuguguuu ccucauggca ucacgcugga ccuggucagc cgccuugucu acugggcaga     1620

ugccuaucug gacuauauug aaguggugga cuaugagggc aagggccgcc agaccaucau     1680

ccagggcauc cugauugagc accuguacgg ccugacugug uuugagaauu aucucuaugc     1740

caccaacucg gacaaugcca augcccagca gaagacgagu gugauccgug ugaaccgcuu     1800

uaacagcacc gaguaccagg uugucacccg gguggacaag gguggugccc uccacaucua     1860

ccaccagagg cgucagcccc gagugaggag ccaugccugu gaaaacgacc aguaugggaa     1920

gccggguggc ugcucugaca ucugccugcu ggccaacagc cacaaggcgc ggaccugccg     1980

cugccguucc ggcuucagcc ugggcaguga cgggaaguca ugcaagaagc cggagcauga     2040

gcuguuccuc guguauggca agggccggcc aggcaucauc cggggcaugg auaugggggc     2100

caaggucccg gaugagcaca ugauccccau ugaaaaccuc augaaccccc gagcccugga     2160

cuuccacgcu gagaccggcu ucaucuacuu ugccgacacc accagcuacc ucauuggccg     2220

ccagaagauu gauggcacug agcgggagac cauccugaag gacggcaucc acaaugugga     2280

ggguguggcc guggacugga ugggagacaa ucuguacugg acggacgaug ggcccaaaaa     2340

gacaaucagc guggccaggc uggagaaagc ugcucagacc cgcaagacuu uaaucgaggg     2400

caaaaugaca caccccaggg cuauuguggu ggauccacuc aaugggugga uguacuggac     2460

agacugggag gaggacccca aggacagucg gcgugggcgg cuggagaggg cguggaugga     2520

uggcucacac cgagacaucu uugucaccuc caagacagug cuuuggccca augggcuaag     2580

ccuggacauc ccggcugggc gccucuacug gguggaugcc uucuacgacc gcaucgagac     2640

gauacugcuc aauggcacag accggaagau uguguaugaa gguccugagc ugaaccacgc     2700

cuuuggccug ugucaccaug gcaacuaccu cuucuggacu gaguaucgga guggcagugu     2760

cuaccgcuug gaacggggug uaggaggcgc accccccacu gugacccuuc ugcgcaguga     2820

gcggcccccc aucuuugaga uccgaaugua ugaugcccag cagcagcaag uuggcaccaa     2880

caaaugccgg gugaacaaug gcggcugcag cagccugugc uuggccaccc cugggagccg     2940

ccagugcgcc ugugcugagg accagguguu ggacgcagac ggcgucacuu gcuuggcgaa     3000

cccauccuac gugccuccac cccagugcca gccaggcgag uuugccugug ccaacagccg     3060

cugcauccag gagcgcugga agugugacgg agacaacgau ugccuggaca acagugauga     3120

ggccccagcc cucugccauc agcacaccug ccccucggac cgauucaagu gcgagaacaa     3180

ccggugcauc cccaaccgcu ggcucugcga cggggacaau gacuguggga acagugaaga     3240

ugaguccaau gccacuuguu cagcccgcac cugccccccc aaccaguucu ccugugccag     3300

uggccgcugc auccccaucu ccuggacgug ugaucuggau gacgacugug gggaccgcuc     3360

ugaugagucu gcuucgugug ccuaucccac cugcuucccc cugacucagu uuaccugcaa     3420

caauggcaga uguaucaaca ucaacuggag augcgacaau gacaaugacu guggggacaa     3480

cagugacgaa gccggcugca gccacuccug uucuagcacc caguucaagu gcaacagcgg     3540

gcguugcauc cccgagcacu ggaccugcga uggggacaau gacugcggag acuacaguga     3600

ugagacacac gccaacugca ccaaccaggc cacgaggccc ccugguggcu gccacacuga     3660

ugaguuccag ugccggcugg auggacuaug caucccccug cgguggcgcu gcgaugggga     3720

cacugacugc auggacucca gcgaugagaa gagcugugag ggagugaccc acgucugcga     3780

ucccaguguc aaguuuggcu gcaaggacuc agcucggugc aucagcaaag cgugggugug     3840

ugauggcgac aaugacugug aggauaacuc ggacgaggag aacugcgagu cccuggccug     3900

caggccaccc ucgcacccuu gugccaacaa caccucaguc ugccugcccc cugacaagcu     3960

gugugauggc aacgacgacu guggcgacgg cucagaugag ggcgagcucu gcgaccagug     4020

cucucugaau aacgguggcu gcagccacaa cugcucagug gcaccuggcg aaggcauugu     4080

guguuccugc ccucugggca uggagcuggg gcccgacaac cacaccugcc agauccagag     4140

cuacugugcc aagcaucuca aaugcagcca aaagugcgac cagaacaagu ucagcgugaa     4200

gugcuccugc uacgagggcu ggguccugga accugacggc gagagcugcc gcagccugga     4260

ccccuucaag ccguucauca uuuucuccaa ccgccaugaa auccggcgca ucgaucuuca     4320

caaaggagac uacagcgucc uggugcccgg ccugcgcaac accaucgccc uggacuucca     4380

ccucagccag agcgcccucu acuggaccga cgugguggag gacaagaucu accgcgggaa     4440

gcugcuggac aacggagccc ugacuaguuu cgagguggug auucaguaug gccuggccac     4500

acccgagggc cuggcuguag acuggauugc aggcaacauc uacugggugg agaguaaccu     4560

ggaucagauc gagguggcca agcuggaugg gacccuccgg accacccugc uggccgguga     4620

cauugagcac ccaagggcaa ucgcacugga uccccgggau gggauccugu uuuggacaga     4680

cugggaugcc agccugcccc gcauugaggc agccuccaug aguggggcug ggcgccgcac     4740

cgugcaccgg gagaccggcu cugggggcug gcccaacggg cucaccgugg acuaccugga     4800

gaagcgcauc cuuuggauug acgccagguc agaugccauu uacucagccc guuacgacgg     4860

cucuggccac auggaggugc uucggggaca cgaguuccug ucgcacccgu uugcagugac     4920

gcuguacggg ggggaggucu acuggacuga cuggcgaaca aacacacugg cuaaggccaa     4980

caaguggacc ggccacaaug ucaccguggu acagaggacc aacacccagc ccuuugaccu     5040

gcagguguac caccccuccc gccagcccau ggcucccaau cccugugagg ccaauggggg     5100

ccagggcccc ugcucccacc ugugucucau caacuacaac cggaccgugu ccugcgccug     5160

cccccaccuc augaagcucc acaaggacaa caccaccugc uaugaguuua agaaguuccu     5220

gcuguacgca cgucagaugg agauccgagg uguggaccug gaugcucccu acuacaacua     5280

caucaucucc uucacggugc ccgacaucga caacgucaca gugcuagacu acgaugcccg     5340

cgagcagcgu guguacuggu cugacgugcg gacacaggcc aucaagcggg ccuucaucaa     5400

cggcacaggc guggagacag ucgucucugc agacuugcca aaugcccacg ggcuggcugu     5460

ggacuggguc ucccgaaacc uguucuggac aagcuaugac accaauaaga agcagaucaa     5520

uguggcccgg cuggauggcu ccuucaagaa cgcaguggug cagggccugg agcagcccca     5580

uggccuuguc guccacccuc ugcgugggaa gcucuacugg accgauggug acaacaucag     5640

cauggccaac auggauggca gcaaucgcac ccugcucuuc aguggccaga agggccccgu     5700

gggccuggcu auugacuucc cugaaagcaa acucuacugg aucagcuccg ggaaccauac     5760

caucaaccgc ugcaaccugg augggagugg gcuggagguc aucgaugcca ugcggagcca     5820

gcugggcaag gccaccgccc uggccaucau gggggacaag cugugguggg cugaucaggu     5880

gucggaaaag augggcacau gcagcaaggc ugacggcucg ggcuccgugg uccuucggaa     5940

cagcaccacc cuggugaugc acaugaaggu cuaugacgag agcauccagc uggaccauaa     6000

gggcaccaac cccugcagug ucaacaacgg ugacugcucc cagcucugcc ugcccacguc     6060

agagacgacc cgcuccugca ugugcacagc cggcuauagc cuccggagug gccagcaggc     6120

cugcgagggc guagguuccu uucuccugua cucugugcau gagggaauca ggggaauucc     6180

ccuggauccc aaugacaagu cagaugcccu ggucccagug uccgggaccu cgcuggcugu     6240

cggcaucgac uuccacgcug aaaaugacac caucuacugg guggacaugg gccugagcac     6300

gaucagccgg gccaagcggg accagacgug gcgugaagac guggugacca auggcauugg     6360

ccguguggag ggcauugcag uggacuggau cgcaggcaac aucuacugga cagaccaggg     6420

cuuugauguc aucgaggucg cccggcucaa uggcuccuuc cgcuacgugg ugaucuccca     6480

gggucuagac aagccccggg ccaucaccgu ccacccggag aaaggguacu uguucuggac     6540

ugaguggggu caguauccgc guauugagcg gucucggcua gauggcacgg agcguguggu     6600

gcuggucaac gucagcauca gcuggcccaa cggcaucuca guggacuacc aggaugggaa     6660

gcuguacugg ugcgaugcac ggacagacaa gauugaacgg aucgaccugg agacagguga     6720

gaaccgcgag gugguucugu ccagcaacaa cauggacaug uuuucagugu cuguguuuga     6780

ggauuucauc uacuggagug acaggacuca ugccaacggc ucuaucaagc gcgggagcaa     6840

agacaaugcc acagacuccg ugccccugcg aaccggcauc ggcguccagc uuaaagacau     6900

caaagucuuc aaccgggacc ggcagaaagg caccaacgug ugcgcggugg ccaauggcgg     6960

gugccagcag cugugccugu accggggccg ugggcagcgg gccugcgccu gugcccacgg     7020

gaugcuggcu gaagacggag caucgugccg cgaguaugcc ggcuaccugc ucuacucaga     7080

gcgcaccauu cucaagagua uccaccuguc ggaugagcgc aaccucaaug cgcccgugca     7140

gcccuucgag gacccugagc acaugaagaa cgucaucgcc cuggccuuug acuaccgggc     7200

aggcaccucu ccgggcaccc ccaaucgcau cuucuucagc gacauccacu uugggaacau     7260

ccaacagauc aacgacgaug gcuccaggag gaucaccauu guggaaaacg ugggcuccgu     7320

ggaaggccug gccuaucacc guggcuggga cacucucuau uggacaagcu acacgacauc     7380

caccaucacg cgccacacag uggaccagac ccgcccaggg gccuucgagc gugagaccgu     7440

caucacuaug ucuggagaug accacccacg ggccuucguu uuggacgagu gccagaaccu     7500

cauguucugg accaacugga augagcagca ucccagcauc augcgggcgg cgcucucggg     7560

agccaauguc cugacccuua ucgagaagga cauccguacc cccaauggcc uggccaucga     7620

ccaccgugcc gagaagcucu acuucucuga cgccacccug gacaagaucg agcggugcga     7680

guaugacggc ucccaccgcu augugauccu aaagucagag ccuguccacc ccuucgggcu     7740

ggccguguau ggggagcaca uuuucuggac ugacugggug cggcgggcag ugcagcgggc     7800

caacaagcac gugggcagca acaugaagcu gcugcgcgug gacauccccc agcagcccau     7860

gggcaucauc gccguggcca acgacaccaa cagcugugaa cucucuccau gccgaaucaa     7920

caacgguggc ugccaggacc ugugucugcu cacucaccag ggccauguca acugcucaug     7980

ccgagggggc cgaauccucc aggaugaccu caccugccga gcggugaauu ccucuugccg     8040

agcacaagau gaguuugagu gugccaaugg cgagugcauc aacuucagcc ugaccugcga     8100

cggcgucccc cacugcaagg acaaguccga ugagaagcca uccuacugca acucccgccg     8160

cugcaagaag acuuuccggc agugcagcaa ugggcgcugu guguccaaca ugcuguggug     8220

caacggggcc gacgacugug gggauggcuc ugacgagauc ccuugcaaca agacagccug     8280

uggugugggc gaguuccgcu gccgggacgg gaccugcauc gggaacucca gccgcugcaa     8340

ccaguuugug gauugugagg acgccucaga ugagaugaac ugcagugcca ccgacugcag     8400

cagcuacuuc cgccugggcg ugaagggcgu gcucuuccag cccugcgagc ggaccucacu     8460

cugcuacgca cccagcuggg ugugugaugg cgccaaugac uguggggacu acagugauga     8520

gcgcgacugc ccagguguga aacgccccag augcccucug aauuacuucg ccugcccuag     8580

ugggcgcugc auccccauga gcuggacgug ugacaaagag gaugacugug aacauggcga     8640

ggacgagacc cacugcaaca aguucugcuc agaggcccag uuugagugcc agaaccaucg     8700

cugcaucucc aagcaguggc ugugugacgg cagcgaugac uguggggaug gcucagacga     8760

ggcugcucac ugugaaggca agacgugcgg ccccuccucc uucuccugcc cuggcaccca     8820

cgugugcguc cccgagcgcu ggcucuguga cggugacaaa gacugugcug auggugcaga     8880

cgagagcauc gcagcugguu gcuuguacaa cagcacuugu gacgaccgug aguucaugug     8940

ccagaaccgc cagugcaucc ccaagcacuu cgugugugac cacgaccgug acugugcaga     9000

uggcucugau gagucccccg agugugagua cccgaccugc ggccccagug aguuccgcug     9060

ugccaauggg cgcugucuga gcucccgcca gugggagugu gauggcgaga augacugcca     9120

cgaccagagu gacgaggcuc ccaagaaccc acacugcacc agccaagagc acaagugcaa     9180

ugccucguca caguuccugu gcagcagugg gcgcugugug gcugaggcac ugcucugcaa     9240

cggccaggau gacuguggcg acagcucgga cgagcguggc ugccacauca augagugucu     9300

cagccgcaag cucaguggcu gcagccagga cugugaggac cucaagaucg gcuucaagug     9360

ccgcugucgc ccuggcuucc ggcugaagga cgacggccgg acgugugcug auguggacga     9420

gugcagcacc accuuccccu gcagccagcg cugcaucaac acucauggca gcuauaagug     9480

ucugugugug gagggcuaug caccccgcgg cggcgacccc cacagcugca aggcugugac     9540

ugacgaggaa ccguuucuga ucuucgccaa ccgguacuac cugcgcaagc ucaaccugga     9600

cggguccaac uacacguuac uuaagcaggg ccugaacaac gccguugccu uggauuuuga     9660

cuaccgagag cagaugaucu acuggacaga ugugaccacc cagggcagca ugauccgaag     9720

gaugcaccuu aacgggagca augugcaggu ccuacaccgu acaggccuca gcaaccccga     9780

ugggcuggcu guggacuggg uggguggcaa ccuguacugg ugcgacaaag gccgggacac     9840

caucgaggug uccaagcuca auggggccua ucggacggug cuggucagcu cuggccuccg     9900

ugagcccagg gcucuggugg uggaugugca gaauggguac cuguacugga cagacugggg     9960

ugaccauuca cugaucggcc gcaucggcau ggaugggucc agccgcagcg ucaucgugga    10020

caccaagauc acauggccca auggccugac gcuggacuau gucacugagc gcaucuacug    10080

ggccgacgcc cgcgaggacu acauugaauu ugccagccug gauggcucca aucgccacgu    10140

ugugcugagc caggacaucc cgcacaucuu ugcacugacc cuguuugagg acuacgucua    10200

cuggaccgac ugggaaacaa aguccauuaa ccgagcccac aagaccacgg gcaccaacaa    10260

aacgcuccuc aucagcacgc ugcaccggcc cauggaccug caugucuucc augcccugcg    10320

ccagccagac gugcccaauc accccugcaa ggucaacaau gguggcugca gcaaccugug    10380

ccugcugucc cccgggggag ggcacaaaug ugccugcccc accaacuucu accugggcag    10440

cgaugggcgc accugugugu ccaacugcac ggcuagccag uuuguaugca agaacgacaa    10500

gugcaucccc uucuggugga agugugacac cgaggacgac ugcggggacc acucagacga    10560

gcccccggac ugcccugagu ucaagugccg gcccggacag uuccagugcu ccacagguau    10620

cugcacaaac ccugccuuca ucugcgaugg cgacaaugac ugccaggaca acagugacga    10680

ggccaacugu gacauccacg ucugcuugcc cagucaguuc aaaugcacca acaccaaccg    10740

cuguauuccc ggcaucuucc gcugcaaugg gcaggacaac ugcggagaug gggaggauga    10800

gagggacugc cccgagguga ccugcgcccc caaccaguuc cagugcucca uuaccaaacg    10860

gugcaucccc cgggucuggg ucugcgaccg ggacaaugac uguguggaug gcagugauga    10920

gcccgccaac ugcacccaga ugaccugugg uguggacgag uuccgcugca aggauucggg    10980

ccgcugcauc ccagcgcguu ggaaguguga cggagaggau gacugugggg auggcucgga    11040

ugagcccaag gaagagugug augaacgcac cugugagcca uaccaguucc gcugcaagaa    11100

caaccgcugc gugcccggcc gcuggcagug cgacuacgac aacgauugcg gugacaacuc    11160

cgaugaagag agcugcaccc cucggcccug cuccgagagu gaguucuccu gugccaacgg    11220

ccgcugcauc gcggggcgcu ggaaaugcga uggagaccac gacugcgcgg acggcucgga    11280

cgagaaagac ugcacccccc gcugugacau ggaccaguuc cagugcaaga gcggccacug    11340

caucccccug cgcuggcgcu gugacgcaga cgccgacugc auggacggca gcgacgagga    11400

ggccugcggc acuggcgugc ggaccugccc ccuggacgag uuccagugca acaacaccuu    11460

gugcaagccg cuggccugga agugcgaugg cgaggaugac uguggggaca acucagauga    11520

gaaccccgag gagugugccc gguucgugug cccucccaac cggcccuucc guugcaagaa    11580

ugaccgcguc ugucugugga ucgggcgcca augcgauggc acggacaacu guggggaugg    11640

gacugaugaa gaggacugug agccccccac agcccacacc acccacugca aagacaagaa    11700

ggaguuucug ugccggaacc agcgcugccu cuccuccucc cugcgcugca acauguucga    11760

ugacugcggg gacggcucug acgaggagga cugcagcauc gaccccaagc ugaccagcug    11820

cgccaccaau gccagcaucu guggggacga ggcacgcugc gugcgcaccg agaaagcggc    11880

cuacugugcc ugccgcucgg gcuuccacac cgugcccggc cagcccggau gccaagacau    11940

caacgagugc cugcgcuucg gcaccugcuc ccagcucugc aacaacacca agggcggcca    12000

ccucugcagc ugcgcucgga acuucaugaa gacgcacaac accugcaagg ccgaaggcuc    12060

ugaguaccag guccuguaca ucgcugauga caaugagauc cgcagccugu uccccggcca    12120

cccccauucg gcuuacgagc aggcauucca gggugacgag aguguccgca uugaugcuau    12180

ggauguccau gucaaggcug gccgugucua uuggaccaac uggcacacgg gcaccaucuc    12240

cuaccgcagc cugccaccug cugcgccucc uaccacuucc aaccgccacc ggcgacagau    12300

ugaccggggu gucacccacc ucaacauuuc agggcugaag augcccagag gcaucgccau    12360

cgacugggug gccggaaacg uguacuggac cgacucgggc cgagauguga uugagguggc    12420

gcagaugaag ggcgagaacc gcaagacgcu caucucgggc augauugacg agccccacgc    12480

cauuguggug gacccacuga gggggaccau guacugguca gacuggggca accaccccaa    12540

gauugagacg gcagcgaugg augggacgcu ucgggagaca cuggugcagg acaacauuca    12600

guggcccaca ggccuggccg uggauuauca caaugagcgg cuguacuggg cagacgccaa    12660

gcuuucaguc aucggcagca uccggcucaa uggcacggac cccauugugg cugcugacag    12720

caaacgaggc cuaagucacc ccuucagcau cgacgucuuu gaggauuaca ucuauggugu    12780

caccuacauc aauaaucgug ucuucaagau ccauaaguuu ggccacagcc ccuuggucaa    12840

ccugacaggg ggccugagcc acgccucuga cgugguccuu uaccaucagc acaagcagcc    12900

cgaagugacc aacccaugug accgcaagaa augcgagugg cucugccugc ugagccccag    12960

ugggccuguc ugcaccuguc ccaaugggaa gcggcuggac aacggcacau gcgugccugu    13020

gcccucucca acgccccccc cagaugcucc ccggccugga accuguaacc ugcagugcuu    13080

caacgguggc agcuguuucc ucaaugcacg gaggcagccc aagugccgcu gccaaccccg    13140

cuacacgggu gacaagugug aacuggacca gugcugggag cacugucgca augggggcac    13200

cugugcugcc ucccccucug gcaugcccac gugccggugc cccacgggcu ucacgggccc    13260

caaaugcacc cagcaggugu gugcgggcua cugugccaac aacagcaccu gcacugucaa    13320

ccagggcaac cagccccagu gccgaugccu acccggcuuc cugggcgacc gcugccagua    13380

ccggcagugc ucuggcuacu gugagaacuu uggcacaugc cagauggcug cugauggcuc    13440

ccgacaaugc cgcugcacug ccuacuuuga gggaucgagg ugugagguga acaagugcag    13500

ccgcugucuc gaaggggccu guguggucaa caagcagagu ggggauguca ccugcaacug    13560

cacggauggc cggguggccc ccagcugucu gaccugcguc ggccacugca gcaauggcgg    13620

cuccuguacc augaacagca aaaugaugcc ugagugccag ugcccacccc acaugacagg    13680

gccccggugu gaggagcacg ucuucagcca gcagcagcca ggacauauag ccuccauccu    13740

aaucccucug cuguugcugc ugcugcuggu ucugguggcc ggagugguau ucugguauaa    13800

gcggcgaguc caaggggcua agggcuucca gcaccaacgg augaccaacg gggccaugaa    13860

cguggagauu ggaaacccca ccuacaagau guacgaaggc ggagagccug augauguggg    13920

aggccuacug gacgcugacu uugcccugga cccugacaag cccaccaacu ucaccaaccc    13980

cguguaugcc acacucuaca uggggggcca uggcagucgc cacucccugg ccagcacgga    14040

cgagaagcga gaacuccugg gccggggccc ugaggacgag auaggggacc ccuuggcaua    14100

gggcccugcc ccgucggacu gcccccagaa agccuccugc ccccugccgg ugaaguccuu    14160

cagugagccc cuccccagcc agcccuuccc uggccccgcc ggauguauaa auguaaaaau    14220

gaaggaauua cauuuuauau gugagcgagc aagccggcaa gcgagcacag uauuauuucu    14280

ccauccccuc ccugccugcu ccuuggcacc cccaugcugc cuucagggag acaggcaggg    14340

agggcuuggg gcugcaccuc cuacccuccc accagaacgc accccacugg gagagcuggu    14400

ggugcagccu uccccucccu guauaagaca cuuugccaag gcucuccccu cucgccccau    14460

cccugcuugc ccgcucccac agcuuccuga gggcuaauuc ugggaaggga gaguucuuug    14520

cugccccugu cuggaagacg uggcucuggg ugagguaggc gggaaaggau ggaguguuuu    14580

aguucuuggg ggaggccacc ccaaacccca gccccaacuc caggggcacc uaugagaugg    14640

ccaugcucaa ccccccuccc agacaggccc ucccugucuc cagggccccc accgagguuc    14700

ccagggcugg agacuuccuc ugguaaacau uccuccagcc uccccucccc uggggacgcc    14760

aaggaggugg gccacaccca ggaagggaaa gcgggcagcc ccguuuuggg gacgugaacg    14820

uuuuaauaau uuuugcugaa uuccuuuaca acuaaauaac acagauauug uuauaaauaa    14880

aauuguaaaa aaaaaaaaaa aaaaa                                          14905


<210>  10
<211>  4544
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Thr Pro Pro Leu Leu Leu Leu Leu Pro Leu Leu Ser Ala Leu 
1               5                   10                  15      


Val Ala Ala Ala Ile Asp Ala Pro Lys Thr Cys Ser Pro Lys Gln Phe 
            20                  25                  30          


Ala Cys Arg Asp Gln Ile Thr Cys Ile Ser Lys Gly Trp Arg Cys Asp 
        35                  40                  45              


Gly Glu Arg Asp Cys Pro Asp Gly Ser Asp Glu Ala Pro Glu Ile Cys 
    50                  55                  60                  


Pro Gln Ser Lys Ala Gln Arg Cys Gln Pro Asn Glu His Asn Cys Leu 
65                  70                  75                  80  


Gly Thr Glu Leu Cys Val Pro Met Ser Arg Leu Cys Asn Gly Val Gln 
                85                  90                  95      


Asp Cys Met Asp Gly Ser Asp Glu Gly Pro His Cys Arg Glu Leu Gln 
            100                 105                 110         


Gly Asn Cys Ser Arg Leu Gly Cys Gln His His Cys Val Pro Thr Leu 
        115                 120                 125             


Asp Gly Pro Thr Cys Tyr Cys Asn Ser Ser Phe Gln Leu Gln Ala Asp 
    130                 135                 140                 


Gly Lys Thr Cys Lys Asp Phe Asp Glu Cys Ser Val Tyr Gly Thr Cys 
145                 150                 155                 160 


Ser Gln Leu Cys Thr Asn Thr Asp Gly Ser Phe Ile Cys Gly Cys Val 
                165                 170                 175     


Glu Gly Tyr Leu Leu Gln Pro Asp Asn Arg Ser Cys Lys Ala Lys Asn 
            180                 185                 190         


Glu Pro Val Asp Arg Pro Pro Val Leu Leu Ile Ala Asn Ser Gln Asn 
        195                 200                 205             


Ile Leu Ala Thr Tyr Leu Ser Gly Ala Gln Val Ser Thr Ile Thr Pro 
    210                 215                 220                 


Thr Ser Thr Arg Gln Thr Thr Ala Met Asp Phe Ser Tyr Ala Asn Glu 
225                 230                 235                 240 


Thr Val Cys Trp Val His Val Gly Asp Ser Ala Ala Gln Thr Gln Leu 
                245                 250                 255     


Lys Cys Ala Arg Met Pro Gly Leu Lys Gly Phe Val Asp Glu His Thr 
            260                 265                 270         


Ile Asn Ile Ser Leu Ser Leu His His Val Glu Gln Met Ala Ile Asp 
        275                 280                 285             


Trp Leu Thr Gly Asn Phe Tyr Phe Val Asp Asp Ile Asp Asp Arg Ile 
    290                 295                 300                 


Phe Val Cys Asn Arg Asn Gly Asp Thr Cys Val Thr Leu Leu Asp Leu 
305                 310                 315                 320 


Glu Leu Tyr Asn Pro Lys Gly Ile Ala Leu Asp Pro Ala Met Gly Lys 
                325                 330                 335     


Val Phe Phe Thr Asp Tyr Gly Gln Ile Pro Lys Val Glu Arg Cys Asp 
            340                 345                 350         


Met Asp Gly Gln Asn Arg Thr Lys Leu Val Asp Ser Lys Ile Val Phe 
        355                 360                 365             


Pro His Gly Ile Thr Leu Asp Leu Val Ser Arg Leu Val Tyr Trp Ala 
    370                 375                 380                 


Asp Ala Tyr Leu Asp Tyr Ile Glu Val Val Asp Tyr Glu Gly Lys Gly 
385                 390                 395                 400 


Arg Gln Thr Ile Ile Gln Gly Ile Leu Ile Glu His Leu Tyr Gly Leu 
                405                 410                 415     


Thr Val Phe Glu Asn Tyr Leu Tyr Ala Thr Asn Ser Asp Asn Ala Asn 
            420                 425                 430         


Ala Gln Gln Lys Thr Ser Val Ile Arg Val Asn Arg Phe Asn Ser Thr 
        435                 440                 445             


Glu Tyr Gln Val Val Thr Arg Val Asp Lys Gly Gly Ala Leu His Ile 
    450                 455                 460                 


Tyr His Gln Arg Arg Gln Pro Arg Val Arg Ser His Ala Cys Glu Asn 
465                 470                 475                 480 


Asp Gln Tyr Gly Lys Pro Gly Gly Cys Ser Asp Ile Cys Leu Leu Ala 
                485                 490                 495     


Asn Ser His Lys Ala Arg Thr Cys Arg Cys Arg Ser Gly Phe Ser Leu 
            500                 505                 510         


Gly Ser Asp Gly Lys Ser Cys Lys Lys Pro Glu His Glu Leu Phe Leu 
        515                 520                 525             


Val Tyr Gly Lys Gly Arg Pro Gly Ile Ile Arg Gly Met Asp Met Gly 
    530                 535                 540                 


Ala Lys Val Pro Asp Glu His Met Ile Pro Ile Glu Asn Leu Met Asn 
545                 550                 555                 560 


Pro Arg Ala Leu Asp Phe His Ala Glu Thr Gly Phe Ile Tyr Phe Ala 
                565                 570                 575     


Asp Thr Thr Ser Tyr Leu Ile Gly Arg Gln Lys Ile Asp Gly Thr Glu 
            580                 585                 590         


Arg Glu Thr Ile Leu Lys Asp Gly Ile His Asn Val Glu Gly Val Ala 
        595                 600                 605             


Val Asp Trp Met Gly Asp Asn Leu Tyr Trp Thr Asp Asp Gly Pro Lys 
    610                 615                 620                 


Lys Thr Ile Ser Val Ala Arg Leu Glu Lys Ala Ala Gln Thr Arg Lys 
625                 630                 635                 640 


Thr Leu Ile Glu Gly Lys Met Thr His Pro Arg Ala Ile Val Val Asp 
                645                 650                 655     


Pro Leu Asn Gly Trp Met Tyr Trp Thr Asp Trp Glu Glu Asp Pro Lys 
            660                 665                 670         


Asp Ser Arg Arg Gly Arg Leu Glu Arg Ala Trp Met Asp Gly Ser His 
        675                 680                 685             


Arg Asp Ile Phe Val Thr Ser Lys Thr Val Leu Trp Pro Asn Gly Leu 
    690                 695                 700                 


Ser Leu Asp Ile Pro Ala Gly Arg Leu Tyr Trp Val Asp Ala Phe Tyr 
705                 710                 715                 720 


Asp Arg Ile Glu Thr Ile Leu Leu Asn Gly Thr Asp Arg Lys Ile Val 
                725                 730                 735     


Tyr Glu Gly Pro Glu Leu Asn His Ala Phe Gly Leu Cys His His Gly 
            740                 745                 750         


Asn Tyr Leu Phe Trp Thr Glu Tyr Arg Ser Gly Ser Val Tyr Arg Leu 
        755                 760                 765             


Glu Arg Gly Val Gly Gly Ala Pro Pro Thr Val Thr Leu Leu Arg Ser 
    770                 775                 780                 


Glu Arg Pro Pro Ile Phe Glu Ile Arg Met Tyr Asp Ala Gln Gln Gln 
785                 790                 795                 800 


Gln Val Gly Thr Asn Lys Cys Arg Val Asn Asn Gly Gly Cys Ser Ser 
                805                 810                 815     


Leu Cys Leu Ala Thr Pro Gly Ser Arg Gln Cys Ala Cys Ala Glu Asp 
            820                 825                 830         


Gln Val Leu Asp Ala Asp Gly Val Thr Cys Leu Ala Asn Pro Ser Tyr 
        835                 840                 845             


Val Pro Pro Pro Gln Cys Gln Pro Gly Glu Phe Ala Cys Ala Asn Ser 
    850                 855                 860                 


Arg Cys Ile Gln Glu Arg Trp Lys Cys Asp Gly Asp Asn Asp Cys Leu 
865                 870                 875                 880 


Asp Asn Ser Asp Glu Ala Pro Ala Leu Cys His Gln His Thr Cys Pro 
                885                 890                 895     


Ser Asp Arg Phe Lys Cys Glu Asn Asn Arg Cys Ile Pro Asn Arg Trp 
            900                 905                 910         


Leu Cys Asp Gly Asp Asn Asp Cys Gly Asn Ser Glu Asp Glu Ser Asn 
        915                 920                 925             


Ala Thr Cys Ser Ala Arg Thr Cys Pro Pro Asn Gln Phe Ser Cys Ala 
    930                 935                 940                 


Ser Gly Arg Cys Ile Pro Ile Ser Trp Thr Cys Asp Leu Asp Asp Asp 
945                 950                 955                 960 


Cys Gly Asp Arg Ser Asp Glu Ser Ala Ser Cys Ala Tyr Pro Thr Cys 
                965                 970                 975     


Phe Pro Leu Thr Gln Phe Thr Cys Asn Asn Gly Arg Cys Ile Asn Ile 
            980                 985                 990         


Asn Trp Arg Cys Asp Asn Asp Asn  Asp Cys Gly Asp Asn  Ser Asp Glu 
        995                 1000                 1005             


Ala Gly  Cys Ser His Ser Cys  Ser Ser Thr Gln Phe  Lys Cys Asn 
    1010                 1015                 1020             


Ser Gly  Arg Cys Ile Pro Glu  His Trp Thr Cys Asp  Gly Asp Asn 
    1025                 1030                 1035             


Asp Cys  Gly Asp Tyr Ser Asp  Glu Thr His Ala Asn  Cys Thr Asn 
    1040                 1045                 1050             


Gln Ala  Thr Arg Pro Pro Gly  Gly Cys His Thr Asp  Glu Phe Gln 
    1055                 1060                 1065             


Cys Arg  Leu Asp Gly Leu Cys  Ile Pro Leu Arg Trp  Arg Cys Asp 
    1070                 1075                 1080             


Gly Asp  Thr Asp Cys Met Asp  Ser Ser Asp Glu Lys  Ser Cys Glu 
    1085                 1090                 1095             


Gly Val  Thr His Val Cys Asp  Pro Ser Val Lys Phe  Gly Cys Lys 
    1100                 1105                 1110             


Asp Ser  Ala Arg Cys Ile Ser  Lys Ala Trp Val Cys  Asp Gly Asp 
    1115                 1120                 1125             


Asn Asp  Cys Glu Asp Asn Ser  Asp Glu Glu Asn Cys  Glu Ser Leu 
    1130                 1135                 1140             


Ala Cys  Arg Pro Pro Ser His  Pro Cys Ala Asn Asn  Thr Ser Val 
    1145                 1150                 1155             


Cys Leu  Pro Pro Asp Lys Leu  Cys Asp Gly Asn Asp  Asp Cys Gly 
    1160                 1165                 1170             


Asp Gly  Ser Asp Glu Gly Glu  Leu Cys Asp Gln Cys  Ser Leu Asn 
    1175                 1180                 1185             


Asn Gly  Gly Cys Ser His Asn  Cys Ser Val Ala Pro  Gly Glu Gly 
    1190                 1195                 1200             


Ile Val  Cys Ser Cys Pro Leu  Gly Met Glu Leu Gly  Pro Asp Asn 
    1205                 1210                 1215             


His Thr  Cys Gln Ile Gln Ser  Tyr Cys Ala Lys His  Leu Lys Cys 
    1220                 1225                 1230             


Ser Gln  Lys Cys Asp Gln Asn  Lys Phe Ser Val Lys  Cys Ser Cys 
    1235                 1240                 1245             


Tyr Glu  Gly Trp Val Leu Glu  Pro Asp Gly Glu Ser  Cys Arg Ser 
    1250                 1255                 1260             


Leu Asp  Pro Phe Lys Pro Phe  Ile Ile Phe Ser Asn  Arg His Glu 
    1265                 1270                 1275             


Ile Arg  Arg Ile Asp Leu His  Lys Gly Asp Tyr Ser  Val Leu Val 
    1280                 1285                 1290             


Pro Gly  Leu Arg Asn Thr Ile  Ala Leu Asp Phe His  Leu Ser Gln 
    1295                 1300                 1305             


Ser Ala  Leu Tyr Trp Thr Asp  Val Val Glu Asp Lys  Ile Tyr Arg 
    1310                 1315                 1320             


Gly Lys  Leu Leu Asp Asn Gly  Ala Leu Thr Ser Phe  Glu Val Val 
    1325                 1330                 1335             


Ile Gln  Tyr Gly Leu Ala Thr  Pro Glu Gly Leu Ala  Val Asp Trp 
    1340                 1345                 1350             


Ile Ala  Gly Asn Ile Tyr Trp  Val Glu Ser Asn Leu  Asp Gln Ile 
    1355                 1360                 1365             


Glu Val  Ala Lys Leu Asp Gly  Thr Leu Arg Thr Thr  Leu Leu Ala 
    1370                 1375                 1380             


Gly Asp  Ile Glu His Pro Arg  Ala Ile Ala Leu Asp  Pro Arg Asp 
    1385                 1390                 1395             


Gly Ile  Leu Phe Trp Thr Asp  Trp Asp Ala Ser Leu  Pro Arg Ile 
    1400                 1405                 1410             


Glu Ala  Ala Ser Met Ser Gly  Ala Gly Arg Arg Thr  Val His Arg 
    1415                 1420                 1425             


Glu Thr  Gly Ser Gly Gly Trp  Pro Asn Gly Leu Thr  Val Asp Tyr 
    1430                 1435                 1440             


Leu Glu  Lys Arg Ile Leu Trp  Ile Asp Ala Arg Ser  Asp Ala Ile 
    1445                 1450                 1455             


Tyr Ser  Ala Arg Tyr Asp Gly  Ser Gly His Met Glu  Val Leu Arg 
    1460                 1465                 1470             


Gly His  Glu Phe Leu Ser His  Pro Phe Ala Val Thr  Leu Tyr Gly 
    1475                 1480                 1485             


Gly Glu  Val Tyr Trp Thr Asp  Trp Arg Thr Asn Thr  Leu Ala Lys 
    1490                 1495                 1500             


Ala Asn  Lys Trp Thr Gly His  Asn Val Thr Val Val  Gln Arg Thr 
    1505                 1510                 1515             


Asn Thr  Gln Pro Phe Asp Leu  Gln Val Tyr His Pro  Ser Arg Gln 
    1520                 1525                 1530             


Pro Met  Ala Pro Asn Pro Cys  Glu Ala Asn Gly Gly  Gln Gly Pro 
    1535                 1540                 1545             


Cys Ser  His Leu Cys Leu Ile  Asn Tyr Asn Arg Thr  Val Ser Cys 
    1550                 1555                 1560             


Ala Cys  Pro His Leu Met Lys  Leu His Lys Asp Asn  Thr Thr Cys 
    1565                 1570                 1575             


Tyr Glu  Phe Lys Lys Phe Leu  Leu Tyr Ala Arg Gln  Met Glu Ile 
    1580                 1585                 1590             


Arg Gly  Val Asp Leu Asp Ala  Pro Tyr Tyr Asn Tyr  Ile Ile Ser 
    1595                 1600                 1605             


Phe Thr  Val Pro Asp Ile Asp  Asn Val Thr Val Leu  Asp Tyr Asp 
    1610                 1615                 1620             


Ala Arg  Glu Gln Arg Val Tyr  Trp Ser Asp Val Arg  Thr Gln Ala 
    1625                 1630                 1635             


Ile Lys  Arg Ala Phe Ile Asn  Gly Thr Gly Val Glu  Thr Val Val 
    1640                 1645                 1650             


Ser Ala  Asp Leu Pro Asn Ala  His Gly Leu Ala Val  Asp Trp Val 
    1655                 1660                 1665             


Ser Arg  Asn Leu Phe Trp Thr  Ser Tyr Asp Thr Asn  Lys Lys Gln 
    1670                 1675                 1680             


Ile Asn  Val Ala Arg Leu Asp  Gly Ser Phe Lys Asn  Ala Val Val 
    1685                 1690                 1695             


Gln Gly  Leu Glu Gln Pro His  Gly Leu Val Val His  Pro Leu Arg 
    1700                 1705                 1710             


Gly Lys  Leu Tyr Trp Thr Asp  Gly Asp Asn Ile Ser  Met Ala Asn 
    1715                 1720                 1725             


Met Asp  Gly Ser Asn Arg Thr  Leu Leu Phe Ser Gly  Gln Lys Gly 
    1730                 1735                 1740             


Pro Val  Gly Leu Ala Ile Asp  Phe Pro Glu Ser Lys  Leu Tyr Trp 
    1745                 1750                 1755             


Ile Ser  Ser Gly Asn His Thr  Ile Asn Arg Cys Asn  Leu Asp Gly 
    1760                 1765                 1770             


Ser Gly  Leu Glu Val Ile Asp  Ala Met Arg Ser Gln  Leu Gly Lys 
    1775                 1780                 1785             


Ala Thr  Ala Leu Ala Ile Met  Gly Asp Lys Leu Trp  Trp Ala Asp 
    1790                 1795                 1800             


Gln Val  Ser Glu Lys Met Gly  Thr Cys Ser Lys Ala  Asp Gly Ser 
    1805                 1810                 1815             


Gly Ser  Val Val Leu Arg Asn  Ser Thr Thr Leu Val  Met His Met 
    1820                 1825                 1830             


Lys Val  Tyr Asp Glu Ser Ile  Gln Leu Asp His Lys  Gly Thr Asn 
    1835                 1840                 1845             


Pro Cys  Ser Val Asn Asn Gly  Asp Cys Ser Gln Leu  Cys Leu Pro 
    1850                 1855                 1860             


Thr Ser  Glu Thr Thr Arg Ser  Cys Met Cys Thr Ala  Gly Tyr Ser 
    1865                 1870                 1875             


Leu Arg  Ser Gly Gln Gln Ala  Cys Glu Gly Val Gly  Ser Phe Leu 
    1880                 1885                 1890             


Leu Tyr  Ser Val His Glu Gly  Ile Arg Gly Ile Pro  Leu Asp Pro 
    1895                 1900                 1905             


Asn Asp  Lys Ser Asp Ala Leu  Val Pro Val Ser Gly  Thr Ser Leu 
    1910                 1915                 1920             


Ala Val  Gly Ile Asp Phe His  Ala Glu Asn Asp Thr  Ile Tyr Trp 
    1925                 1930                 1935             


Val Asp  Met Gly Leu Ser Thr  Ile Ser Arg Ala Lys  Arg Asp Gln 
    1940                 1945                 1950             


Thr Trp  Arg Glu Asp Val Val  Thr Asn Gly Ile Gly  Arg Val Glu 
    1955                 1960                 1965             


Gly Ile  Ala Val Asp Trp Ile  Ala Gly Asn Ile Tyr  Trp Thr Asp 
    1970                 1975                 1980             


Gln Gly  Phe Asp Val Ile Glu  Val Ala Arg Leu Asn  Gly Ser Phe 
    1985                 1990                 1995             


Arg Tyr  Val Val Ile Ser Gln  Gly Leu Asp Lys Pro  Arg Ala Ile 
    2000                 2005                 2010             


Thr Val  His Pro Glu Lys Gly  Tyr Leu Phe Trp Thr  Glu Trp Gly 
    2015                 2020                 2025             


Gln Tyr  Pro Arg Ile Glu Arg  Ser Arg Leu Asp Gly  Thr Glu Arg 
    2030                 2035                 2040             


Val Val  Leu Val Asn Val Ser  Ile Ser Trp Pro Asn  Gly Ile Ser 
    2045                 2050                 2055             


Val Asp  Tyr Gln Asp Gly Lys  Leu Tyr Trp Cys Asp  Ala Arg Thr 
    2060                 2065                 2070             


Asp Lys  Ile Glu Arg Ile Asp  Leu Glu Thr Gly Glu  Asn Arg Glu 
    2075                 2080                 2085             


Val Val  Leu Ser Ser Asn Asn  Met Asp Met Phe Ser  Val Ser Val 
    2090                 2095                 2100             


Phe Glu  Asp Phe Ile Tyr Trp  Ser Asp Arg Thr His  Ala Asn Gly 
    2105                 2110                 2115             


Ser Ile  Lys Arg Gly Ser Lys  Asp Asn Ala Thr Asp  Ser Val Pro 
    2120                 2125                 2130             


Leu Arg  Thr Gly Ile Gly Val  Gln Leu Lys Asp Ile  Lys Val Phe 
    2135                 2140                 2145             


Asn Arg  Asp Arg Gln Lys Gly  Thr Asn Val Cys Ala  Val Ala Asn 
    2150                 2155                 2160             


Gly Gly  Cys Gln Gln Leu Cys  Leu Tyr Arg Gly Arg  Gly Gln Arg 
    2165                 2170                 2175             


Ala Cys  Ala Cys Ala His Gly  Met Leu Ala Glu Asp  Gly Ala Ser 
    2180                 2185                 2190             


Cys Arg  Glu Tyr Ala Gly Tyr  Leu Leu Tyr Ser Glu  Arg Thr Ile 
    2195                 2200                 2205             


Leu Lys  Ser Ile His Leu Ser  Asp Glu Arg Asn Leu  Asn Ala Pro 
    2210                 2215                 2220             


Val Gln  Pro Phe Glu Asp Pro  Glu His Met Lys Asn  Val Ile Ala 
    2225                 2230                 2235             


Leu Ala  Phe Asp Tyr Arg Ala  Gly Thr Ser Pro Gly  Thr Pro Asn 
    2240                 2245                 2250             


Arg Ile  Phe Phe Ser Asp Ile  His Phe Gly Asn Ile  Gln Gln Ile 
    2255                 2260                 2265             


Asn Asp  Asp Gly Ser Arg Arg  Ile Thr Ile Val Glu  Asn Val Gly 
    2270                 2275                 2280             


Ser Val  Glu Gly Leu Ala Tyr  His Arg Gly Trp Asp  Thr Leu Tyr 
    2285                 2290                 2295             


Trp Thr  Ser Tyr Thr Thr Ser  Thr Ile Thr Arg His  Thr Val Asp 
    2300                 2305                 2310             


Gln Thr  Arg Pro Gly Ala Phe  Glu Arg Glu Thr Val  Ile Thr Met 
    2315                 2320                 2325             


Ser Gly  Asp Asp His Pro Arg  Ala Phe Val Leu Asp  Glu Cys Gln 
    2330                 2335                 2340             


Asn Leu  Met Phe Trp Thr Asn  Trp Asn Glu Gln His  Pro Ser Ile 
    2345                 2350                 2355             


Met Arg  Ala Ala Leu Ser Gly  Ala Asn Val Leu Thr  Leu Ile Glu 
    2360                 2365                 2370             


Lys Asp  Ile Arg Thr Pro Asn  Gly Leu Ala Ile Asp  His Arg Ala 
    2375                 2380                 2385             


Glu Lys  Leu Tyr Phe Ser Asp  Ala Thr Leu Asp Lys  Ile Glu Arg 
    2390                 2395                 2400             


Cys Glu  Tyr Asp Gly Ser His  Arg Tyr Val Ile Leu  Lys Ser Glu 
    2405                 2410                 2415             


Pro Val  His Pro Phe Gly Leu  Ala Val Tyr Gly Glu  His Ile Phe 
    2420                 2425                 2430             


Trp Thr  Asp Trp Val Arg Arg  Ala Val Gln Arg Ala  Asn Lys His 
    2435                 2440                 2445             


Val Gly  Ser Asn Met Lys Leu  Leu Arg Val Asp Ile  Pro Gln Gln 
    2450                 2455                 2460             


Pro Met  Gly Ile Ile Ala Val  Ala Asn Asp Thr Asn  Ser Cys Glu 
    2465                 2470                 2475             


Leu Ser  Pro Cys Arg Ile Asn  Asn Gly Gly Cys Gln  Asp Leu Cys 
    2480                 2485                 2490             


Leu Leu  Thr His Gln Gly His  Val Asn Cys Ser Cys  Arg Gly Gly 
    2495                 2500                 2505             


Arg Ile  Leu Gln Asp Asp Leu  Thr Cys Arg Ala Val  Asn Ser Ser 
    2510                 2515                 2520             


Cys Arg  Ala Gln Asp Glu Phe  Glu Cys Ala Asn Gly  Glu Cys Ile 
    2525                 2530                 2535             


Asn Phe  Ser Leu Thr Cys Asp  Gly Val Pro His Cys  Lys Asp Lys 
    2540                 2545                 2550             


Ser Asp  Glu Lys Pro Ser Tyr  Cys Asn Ser Arg Arg  Cys Lys Lys 
    2555                 2560                 2565             


Thr Phe  Arg Gln Cys Ser Asn  Gly Arg Cys Val Ser  Asn Met Leu 
    2570                 2575                 2580             


Trp Cys  Asn Gly Ala Asp Asp  Cys Gly Asp Gly Ser  Asp Glu Ile 
    2585                 2590                 2595             


Pro Cys  Asn Lys Thr Ala Cys  Gly Val Gly Glu Phe  Arg Cys Arg 
    2600                 2605                 2610             


Asp Gly  Thr Cys Ile Gly Asn  Ser Ser Arg Cys Asn  Gln Phe Val 
    2615                 2620                 2625             


Asp Cys  Glu Asp Ala Ser Asp  Glu Met Asn Cys Ser  Ala Thr Asp 
    2630                 2635                 2640             


Cys Ser  Ser Tyr Phe Arg Leu  Gly Val Lys Gly Val  Leu Phe Gln 
    2645                 2650                 2655             


Pro Cys  Glu Arg Thr Ser Leu  Cys Tyr Ala Pro Ser  Trp Val Cys 
    2660                 2665                 2670             


Asp Gly  Ala Asn Asp Cys Gly  Asp Tyr Ser Asp Glu  Arg Asp Cys 
    2675                 2680                 2685             


Pro Gly  Val Lys Arg Pro Arg  Cys Pro Leu Asn Tyr  Phe Ala Cys 
    2690                 2695                 2700             


Pro Ser  Gly Arg Cys Ile Pro  Met Ser Trp Thr Cys  Asp Lys Glu 
    2705                 2710                 2715             


Asp Asp  Cys Glu His Gly Glu  Asp Glu Thr His Cys  Asn Lys Phe 
    2720                 2725                 2730             


Cys Ser  Glu Ala Gln Phe Glu  Cys Gln Asn His Arg  Cys Ile Ser 
    2735                 2740                 2745             


Lys Gln  Trp Leu Cys Asp Gly  Ser Asp Asp Cys Gly  Asp Gly Ser 
    2750                 2755                 2760             


Asp Glu  Ala Ala His Cys Glu  Gly Lys Thr Cys Gly  Pro Ser Ser 
    2765                 2770                 2775             


Phe Ser  Cys Pro Gly Thr His  Val Cys Val Pro Glu  Arg Trp Leu 
    2780                 2785                 2790             


Cys Asp  Gly Asp Lys Asp Cys  Ala Asp Gly Ala Asp  Glu Ser Ile 
    2795                 2800                 2805             


Ala Ala  Gly Cys Leu Tyr Asn  Ser Thr Cys Asp Asp  Arg Glu Phe 
    2810                 2815                 2820             


Met Cys  Gln Asn Arg Gln Cys  Ile Pro Lys His Phe  Val Cys Asp 
    2825                 2830                 2835             


His Asp  Arg Asp Cys Ala Asp  Gly Ser Asp Glu Ser  Pro Glu Cys 
    2840                 2845                 2850             


Glu Tyr  Pro Thr Cys Gly Pro  Ser Glu Phe Arg Cys  Ala Asn Gly 
    2855                 2860                 2865             


Arg Cys  Leu Ser Ser Arg Gln  Trp Glu Cys Asp Gly  Glu Asn Asp 
    2870                 2875                 2880             


Cys His  Asp Gln Ser Asp Glu  Ala Pro Lys Asn Pro  His Cys Thr 
    2885                 2890                 2895             


Ser Gln  Glu His Lys Cys Asn  Ala Ser Ser Gln Phe  Leu Cys Ser 
    2900                 2905                 2910             


Ser Gly  Arg Cys Val Ala Glu  Ala Leu Leu Cys Asn  Gly Gln Asp 
    2915                 2920                 2925             


Asp Cys  Gly Asp Ser Ser Asp  Glu Arg Gly Cys His  Ile Asn Glu 
    2930                 2935                 2940             


Cys Leu  Ser Arg Lys Leu Ser  Gly Cys Ser Gln Asp  Cys Glu Asp 
    2945                 2950                 2955             


Leu Lys  Ile Gly Phe Lys Cys  Arg Cys Arg Pro Gly  Phe Arg Leu 
    2960                 2965                 2970             


Lys Asp  Asp Gly Arg Thr Cys  Ala Asp Val Asp Glu  Cys Ser Thr 
    2975                 2980                 2985             


Thr Phe  Pro Cys Ser Gln Arg  Cys Ile Asn Thr His  Gly Ser Tyr 
    2990                 2995                 3000             


Lys Cys  Leu Cys Val Glu Gly  Tyr Ala Pro Arg Gly  Gly Asp Pro 
    3005                 3010                 3015             


His Ser  Cys Lys Ala Val Thr  Asp Glu Glu Pro Phe  Leu Ile Phe 
    3020                 3025                 3030             


Ala Asn  Arg Tyr Tyr Leu Arg  Lys Leu Asn Leu Asp  Gly Ser Asn 
    3035                 3040                 3045             


Tyr Thr  Leu Leu Lys Gln Gly  Leu Asn Asn Ala Val  Ala Leu Asp 
    3050                 3055                 3060             


Phe Asp  Tyr Arg Glu Gln Met  Ile Tyr Trp Thr Asp  Val Thr Thr 
    3065                 3070                 3075             


Gln Gly  Ser Met Ile Arg Arg  Met His Leu Asn Gly  Ser Asn Val 
    3080                 3085                 3090             


Gln Val  Leu His Arg Thr Gly  Leu Ser Asn Pro Asp  Gly Leu Ala 
    3095                 3100                 3105             


Val Asp  Trp Val Gly Gly Asn  Leu Tyr Trp Cys Asp  Lys Gly Arg 
    3110                 3115                 3120             


Asp Thr  Ile Glu Val Ser Lys  Leu Asn Gly Ala Tyr  Arg Thr Val 
    3125                 3130                 3135             


Leu Val  Ser Ser Gly Leu Arg  Glu Pro Arg Ala Leu  Val Val Asp 
    3140                 3145                 3150             


Val Gln  Asn Gly Tyr Leu Tyr  Trp Thr Asp Trp Gly  Asp His Ser 
    3155                 3160                 3165             


Leu Ile  Gly Arg Ile Gly Met  Asp Gly Ser Ser Arg  Ser Val Ile 
    3170                 3175                 3180             


Val Asp  Thr Lys Ile Thr Trp  Pro Asn Gly Leu Thr  Leu Asp Tyr 
    3185                 3190                 3195             


Val Thr  Glu Arg Ile Tyr Trp  Ala Asp Ala Arg Glu  Asp Tyr Ile 
    3200                 3205                 3210             


Glu Phe  Ala Ser Leu Asp Gly  Ser Asn Arg His Val  Val Leu Ser 
    3215                 3220                 3225             


Gln Asp  Ile Pro His Ile Phe  Ala Leu Thr Leu Phe  Glu Asp Tyr 
    3230                 3235                 3240             


Val Tyr  Trp Thr Asp Trp Glu  Thr Lys Ser Ile Asn  Arg Ala His 
    3245                 3250                 3255             


Lys Thr  Thr Gly Thr Asn Lys  Thr Leu Leu Ile Ser  Thr Leu His 
    3260                 3265                 3270             


Arg Pro  Met Asp Leu His Val  Phe His Ala Leu Arg  Gln Pro Asp 
    3275                 3280                 3285             


Val Pro  Asn His Pro Cys Lys  Val Asn Asn Gly Gly  Cys Ser Asn 
    3290                 3295                 3300             


Leu Cys  Leu Leu Ser Pro Gly  Gly Gly His Lys Cys  Ala Cys Pro 
    3305                 3310                 3315             


Thr Asn  Phe Tyr Leu Gly Ser  Asp Gly Arg Thr Cys  Val Ser Asn 
    3320                 3325                 3330             


Cys Thr  Ala Ser Gln Phe Val  Cys Lys Asn Asp Lys  Cys Ile Pro 
    3335                 3340                 3345             


Phe Trp  Trp Lys Cys Asp Thr  Glu Asp Asp Cys Gly  Asp His Ser 
    3350                 3355                 3360             


Asp Glu  Pro Pro Asp Cys Pro  Glu Phe Lys Cys Arg  Pro Gly Gln 
    3365                 3370                 3375             


Phe Gln  Cys Ser Thr Gly Ile  Cys Thr Asn Pro Ala  Phe Ile Cys 
    3380                 3385                 3390             


Asp Gly  Asp Asn Asp Cys Gln  Asp Asn Ser Asp Glu  Ala Asn Cys 
    3395                 3400                 3405             


Asp Ile  His Val Cys Leu Pro  Ser Gln Phe Lys Cys  Thr Asn Thr 
    3410                 3415                 3420             


Asn Arg  Cys Ile Pro Gly Ile  Phe Arg Cys Asn Gly  Gln Asp Asn 
    3425                 3430                 3435             


Cys Gly  Asp Gly Glu Asp Glu  Arg Asp Cys Pro Glu  Val Thr Cys 
    3440                 3445                 3450             


Ala Pro  Asn Gln Phe Gln Cys  Ser Ile Thr Lys Arg  Cys Ile Pro 
    3455                 3460                 3465             


Arg Val  Trp Val Cys Asp Arg  Asp Asn Asp Cys Val  Asp Gly Ser 
    3470                 3475                 3480             


Asp Glu  Pro Ala Asn Cys Thr  Gln Met Thr Cys Gly  Val Asp Glu 
    3485                 3490                 3495             


Phe Arg  Cys Lys Asp Ser Gly  Arg Cys Ile Pro Ala  Arg Trp Lys 
    3500                 3505                 3510             


Cys Asp  Gly Glu Asp Asp Cys  Gly Asp Gly Ser Asp  Glu Pro Lys 
    3515                 3520                 3525             


Glu Glu  Cys Asp Glu Arg Thr  Cys Glu Pro Tyr Gln  Phe Arg Cys 
    3530                 3535                 3540             


Lys Asn  Asn Arg Cys Val Pro  Gly Arg Trp Gln Cys  Asp Tyr Asp 
    3545                 3550                 3555             


Asn Asp  Cys Gly Asp Asn Ser  Asp Glu Glu Ser Cys  Thr Pro Arg 
    3560                 3565                 3570             


Pro Cys  Ser Glu Ser Glu Phe  Ser Cys Ala Asn Gly  Arg Cys Ile 
    3575                 3580                 3585             


Ala Gly  Arg Trp Lys Cys Asp  Gly Asp His Asp Cys  Ala Asp Gly 
    3590                 3595                 3600             


Ser Asp  Glu Lys Asp Cys Thr  Pro Arg Cys Asp Met  Asp Gln Phe 
    3605                 3610                 3615             


Gln Cys  Lys Ser Gly His Cys  Ile Pro Leu Arg Trp  Arg Cys Asp 
    3620                 3625                 3630             


Ala Asp  Ala Asp Cys Met Asp  Gly Ser Asp Glu Glu  Ala Cys Gly 
    3635                 3640                 3645             


Thr Gly  Val Arg Thr Cys Pro  Leu Asp Glu Phe Gln  Cys Asn Asn 
    3650                 3655                 3660             


Thr Leu  Cys Lys Pro Leu Ala  Trp Lys Cys Asp Gly  Glu Asp Asp 
    3665                 3670                 3675             


Cys Gly  Asp Asn Ser Asp Glu  Asn Pro Glu Glu Cys  Ala Arg Phe 
    3680                 3685                 3690             


Val Cys  Pro Pro Asn Arg Pro  Phe Arg Cys Lys Asn  Asp Arg Val 
    3695                 3700                 3705             


Cys Leu  Trp Ile Gly Arg Gln  Cys Asp Gly Thr Asp  Asn Cys Gly 
    3710                 3715                 3720             


Asp Gly  Thr Asp Glu Glu Asp  Cys Glu Pro Pro Thr  Ala His Thr 
    3725                 3730                 3735             


Thr His  Cys Lys Asp Lys Lys  Glu Phe Leu Cys Arg  Asn Gln Arg 
    3740                 3745                 3750             


Cys Leu  Ser Ser Ser Leu Arg  Cys Asn Met Phe Asp  Asp Cys Gly 
    3755                 3760                 3765             


Asp Gly  Ser Asp Glu Glu Asp  Cys Ser Ile Asp Pro  Lys Leu Thr 
    3770                 3775                 3780             


Ser Cys  Ala Thr Asn Ala Ser  Ile Cys Gly Asp Glu  Ala Arg Cys 
    3785                 3790                 3795             


Val Arg  Thr Glu Lys Ala Ala  Tyr Cys Ala Cys Arg  Ser Gly Phe 
    3800                 3805                 3810             


His Thr  Val Pro Gly Gln Pro  Gly Cys Gln Asp Ile  Asn Glu Cys 
    3815                 3820                 3825             


Leu Arg  Phe Gly Thr Cys Ser  Gln Leu Cys Asn Asn  Thr Lys Gly 
    3830                 3835                 3840             


Gly His  Leu Cys Ser Cys Ala  Arg Asn Phe Met Lys  Thr His Asn 
    3845                 3850                 3855             


Thr Cys  Lys Ala Glu Gly Ser  Glu Tyr Gln Val Leu  Tyr Ile Ala 
    3860                 3865                 3870             


Asp Asp  Asn Glu Ile Arg Ser  Leu Phe Pro Gly His  Pro His Ser 
    3875                 3880                 3885             


Ala Tyr  Glu Gln Ala Phe Gln  Gly Asp Glu Ser Val  Arg Ile Asp 
    3890                 3895                 3900             


Ala Met  Asp Val His Val Lys  Ala Gly Arg Val Tyr  Trp Thr Asn 
    3905                 3910                 3915             


Trp His  Thr Gly Thr Ile Ser  Tyr Arg Ser Leu Pro  Pro Ala Ala 
    3920                 3925                 3930             


Pro Pro  Thr Thr Ser Asn Arg  His Arg Arg Gln Ile  Asp Arg Gly 
    3935                 3940                 3945             


Val Thr  His Leu Asn Ile Ser  Gly Leu Lys Met Pro  Arg Gly Ile 
    3950                 3955                 3960             


Ala Ile  Asp Trp Val Ala Gly  Asn Val Tyr Trp Thr  Asp Ser Gly 
    3965                 3970                 3975             


Arg Asp  Val Ile Glu Val Ala  Gln Met Lys Gly Glu  Asn Arg Lys 
    3980                 3985                 3990             


Thr Leu  Ile Ser Gly Met Ile  Asp Glu Pro His Ala  Ile Val Val 
    3995                 4000                 4005             


Asp Pro  Leu Arg Gly Thr Met  Tyr Trp Ser Asp Trp  Gly Asn His 
    4010                 4015                 4020             


Pro Lys  Ile Glu Thr Ala Ala  Met Asp Gly Thr Leu  Arg Glu Thr 
    4025                 4030                 4035             


Leu Val  Gln Asp Asn Ile Gln  Trp Pro Thr Gly Leu  Ala Val Asp 
    4040                 4045                 4050             


Tyr His  Asn Glu Arg Leu Tyr  Trp Ala Asp Ala Lys  Leu Ser Val 
    4055                 4060                 4065             


Ile Gly  Ser Ile Arg Leu Asn  Gly Thr Asp Pro Ile  Val Ala Ala 
    4070                 4075                 4080             


Asp Ser  Lys Arg Gly Leu Ser  His Pro Phe Ser Ile  Asp Val Phe 
    4085                 4090                 4095             


Glu Asp  Tyr Ile Tyr Gly Val  Thr Tyr Ile Asn Asn  Arg Val Phe 
    4100                 4105                 4110             


Lys Ile  His Lys Phe Gly His  Ser Pro Leu Val Asn  Leu Thr Gly 
    4115                 4120                 4125             


Gly Leu  Ser His Ala Ser Asp  Val Val Leu Tyr His  Gln His Lys 
    4130                 4135                 4140             


Gln Pro  Glu Val Thr Asn Pro  Cys Asp Arg Lys Lys  Cys Glu Trp 
    4145                 4150                 4155             


Leu Cys  Leu Leu Ser Pro Ser  Gly Pro Val Cys Thr  Cys Pro Asn 
    4160                 4165                 4170             


Gly Lys  Arg Leu Asp Asn Gly  Thr Cys Val Pro Val  Pro Ser Pro 
    4175                 4180                 4185             


Thr Pro  Pro Pro Asp Ala Pro  Arg Pro Gly Thr Cys  Asn Leu Gln 
    4190                 4195                 4200             


Cys Phe  Asn Gly Gly Ser Cys  Phe Leu Asn Ala Arg  Arg Gln Pro 
    4205                 4210                 4215             


Lys Cys  Arg Cys Gln Pro Arg  Tyr Thr Gly Asp Lys  Cys Glu Leu 
    4220                 4225                 4230             


Asp Gln  Cys Trp Glu His Cys  Arg Asn Gly Gly Thr  Cys Ala Ala 
    4235                 4240                 4245             


Ser Pro  Ser Gly Met Pro Thr  Cys Arg Cys Pro Thr  Gly Phe Thr 
    4250                 4255                 4260             


Gly Pro  Lys Cys Thr Gln Gln  Val Cys Ala Gly Tyr  Cys Ala Asn 
    4265                 4270                 4275             


Asn Ser  Thr Cys Thr Val Asn  Gln Gly Asn Gln Pro  Gln Cys Arg 
    4280                 4285                 4290             


Cys Leu  Pro Gly Phe Leu Gly  Asp Arg Cys Gln Tyr  Arg Gln Cys 
    4295                 4300                 4305             


Ser Gly  Tyr Cys Glu Asn Phe  Gly Thr Cys Gln Met  Ala Ala Asp 
    4310                 4315                 4320             


Gly Ser  Arg Gln Cys Arg Cys  Thr Ala Tyr Phe Glu  Gly Ser Arg 
    4325                 4330                 4335             


Cys Glu  Val Asn Lys Cys Ser  Arg Cys Leu Glu Gly  Ala Cys Val 
    4340                 4345                 4350             


Val Asn  Lys Gln Ser Gly Asp  Val Thr Cys Asn Cys  Thr Asp Gly 
    4355                 4360                 4365             


Arg Val  Ala Pro Ser Cys Leu  Thr Cys Val Gly His  Cys Ser Asn 
    4370                 4375                 4380             


Gly Gly  Ser Cys Thr Met Asn  Ser Lys Met Met Pro  Glu Cys Gln 
    4385                 4390                 4395             


Cys Pro  Pro His Met Thr Gly  Pro Arg Cys Glu Glu  His Val Phe 
    4400                 4405                 4410             


Ser Gln  Gln Gln Pro Gly His  Ile Ala Ser Ile Leu  Ile Pro Leu 
    4415                 4420                 4425             


Leu Leu  Leu Leu Leu Leu Val  Leu Val Ala Gly Val  Val Phe Trp 
    4430                 4435                 4440             


Tyr Lys  Arg Arg Val Gln Gly  Ala Lys Gly Phe Gln  His Gln Arg 
    4445                 4450                 4455             


Met Thr  Asn Gly Ala Met Asn  Val Glu Ile Gly Asn  Pro Thr Tyr 
    4460                 4465                 4470             


Lys Met  Tyr Glu Gly Gly Glu  Pro Asp Asp Val Gly  Gly Leu Leu 
    4475                 4480                 4485             


Asp Ala  Asp Phe Ala Leu Asp  Pro Asp Lys Pro Thr  Asn Phe Thr 
    4490                 4495                 4500             


Asn Pro  Val Tyr Ala Thr Leu  Tyr Met Gly Gly His  Gly Ser Arg 
    4505                 4510                 4515             


His Ser  Leu Ala Ser Thr Asp  Glu Lys Arg Glu Leu  Leu Gly Arg 
    4520                 4525                 4530             


Gly Pro  Glu Asp Glu Ile Gly  Asp Pro Leu Ala 
    4535                 4540                 


<210>  11
<211>  7783
<212>  RNA
<213>  Homo sapiens

<400>  11
gcuggcggcg gccgcccagg gccggggccg cgcgcccagc cugagcccgc cccgccgccg       60

agcgucaccg aaccugcuug aaaugcagcc gaggagccgg ggcgggcggc agcggcggcg      120

gcggcggcgg cgggggcagc ggcaaccccg gcgccgcggc aaggacucgg agggcugaga      180

cgcggcggcg gcggcgcggg gagcgcgggg cgcggcggcc ggagccccgg gcccgccaug      240

ggccuccccg agccgggccc ucuccggcuu cuggcgcugc ugcugcugcu gcugcugcug      300

cugcugcugc agcuccagca ucuugcggcg gcagcggcug auccgcugcu cggcggccaa      360

gggccggcca aggauugcga aaaggaccaa uuccagugcc ggaacgagcg cugcaucccc      420

ucugugugga gaugcgacga ggacgaugac ugcuuagacc acagcgacga ggacgacugc      480

cccaagaaga ccugugcaga cagugacuuc accugugaca acggccacug cauccacgaa      540

cgguggaagu gugacggcga ggaggagugu ccugauggcu ccgaugaguc cgaggccacu      600

ugcaccaagc aggugugucc ugcagagaag cugagcugug gacccaccag ccacaagugu      660

guaccugccu cguggcgcug cgacggggag aaggacugcg aggguggagc ggaugaggcc      720

ggcugugcua ccuugugcgc cccgcacgag uuccagugcg gcaaccgcuc gugccuggcc      780

gccguguucg ugugcgacgg cgacgacgac uguggugacg gcagcgauga gcgcggcugu      840

gcagacccgg ccugcgggcc ccgcgaguuc cgcugcggcg gcgauggcgg cggcgccugc      900

aucccggagc gcugggucug cgaccgccag uuugacugcg aggaccgcuc ggacgaggca      960

gccgagcucu gcggccgucc gggccccggg gccacguccg cgcccgccgc cugcgccacc     1020

gccucccagu ucgccugccg cagcggcgag ugcgugcacc ugggcuggcg cugcgacggc     1080

gaccgcgacu gcaaagacaa aucggacgag gccgacugcc cacugggcac cugccguggg     1140

gacgaguucc agugugggga ugggacaugu guccuugcaa ucaagcacug caaccaggag     1200

caggacuguc cagaugggag ugaugaagcu ggcugccuac aggggcugaa cgagugucug     1260

cacaacaaug gcggcugcuc acacaucugc acugaccuca agauuggcuu ugaaugcacg     1320

ugcccagcag gcuuccagcu ccuggaccag aagaccugug gcgacauuga ugagugcaag     1380

gacccagaug ccugcagcca gaucuguguc aauuacaagg gcuauuuuaa gugugagugc     1440

uacccuggcu acgagaugga ccuacugacc aagaacugca aggcugcugc uggcaagagc     1500

ccaucccuaa ucuucaccaa ccggcacgag gugcggagga ucgaccuggu gaagcggaac     1560

uauucacgcc ucauccccau gcucaagaau gucguggcac uagaugugga aguugccacc     1620

aaucgcaucu acugguguga ccucuccuac cguaagaucu auagcgccua cauggacaag     1680

gccagugacc cgaaagagca ggagguccuc auugacgagc aguugcacuc uccagagggc     1740

cuggcagugg acugggucca caagcacauc uacuggacug acucgggcaa uaagaccauc     1800

ucaguggcca caguugaugg uggccgccga cgcacucucu ucagccguaa ccucagugaa     1860

ccccgggcca ucgcuguuga cccccugcga ggguucaugu auuggucuga cuggggggac     1920

caggccaaga uugagaaauc ugggcucaac gguguggacc ggcaaacacu ggugucagac     1980

aauauugaau ggcccaacgg aaucacccug gaucugcuga gccagcgcuu guacugggua     2040

gacuccaagc uacaccaacu guccagcauu gacuucagug gaggcaacag aaagacgcug     2100

aucuccucca cugacuuccu gagccacccu uuugggauag cuguguuuga ggacaaggug     2160

uucuggacag accuggagaa cgaggccauu uucagugcaa aucggcucaa uggccuggaa     2220

aucuccaucc uggcugagaa ccucaacaac ccacaugaca uugucaucuu ccaugagcug     2280

aagcagccaa gagcuccaga ugccugugag cugagugucc agccuaaugg aggcugugaa     2340

uaccugugcc uuccugcucc ucagaucucc agccacucuc ccaaguacac augugccugu     2400

ccugacacaa uguggcuggg uccagacaug aagaggugcu accgagcacc ucaaucuacc     2460

ucaacuacga cguuagcuuc uaccaugacg aggacaguac cugccaccac aagagccccc     2520

gggaccaccg uccacagauc caccuaccag aaccacagca cagagacacc aagccugaca     2580

gcugcagucc caagcucagu uagugucccc agggcuccca gcaucagccc gucuacccua     2640

agcccugcaa ccagcaacca cucccagcac uaugcaaaug aagacaguaa gaugggcuca     2700

acagucacug ccgcuguuau cgggaucauc gugcccauag uggugauagc ccuccugugc     2760

augaguggau accugaucug gagaaacugg aagcggaaga acaccaaaag caugaauuuu     2820

gacaacccag ucuacaggaa aacaacagaa gaagaagacg aagaugagcu ccauauaggg     2880

agaacugcuc agauuggcca ugucuauccu gcagcaauca gcagcuuuga ucgcccacug     2940

ugggcagagc ccugucuugg ggagaccaga gaaccggaag acccagcccc ugcccucaag     3000

gagcuuuuug ucuugccggg ggaaccaagg ucacagcugc accaacuccc gaagaacccu     3060

cuuuccgagc ugccugucgu caaauccaag cgaguggcau uaagccuuga agaugaugga     3120

cuacccugag gaugggauca cccccuucgu gccucaugga auucaguccc augcacuaca     3180

cucuggaugg uguaugacug gaugaauggg uuucuauaua ugggucugug ugaguguaug     3240

ugugugugug auuuuuuuuu uaaauuuaug uugcggaaag guaaccacaa aguuaugaug     3300

aacugcaaac auccaaagga ugugagaguu uuucuaugua uaauguuuua uacacuuuuu     3360

aacugguugc acuacccaug aggaauucgu ggaauggcua cugcugacua acaugaugca     3420

cauaaccaaa ugggggccaa uggcacagua ccuuacucau cauuuaaaaa cuauauuuac     3480

agaagauguu ugguugcugg gggggcuuuu uuagguuuug gggcauuugu uuuuuguaaa     3540

uaagaugauu augcuuugug gcuauccauc aacauaagua aaaaaaaaaa aaaaacacuu     3600

caacucccuc ccccauuuag auuauuuauu aacauauuuu aaaaaucaga ugaguucuau     3660

aaauaauuua gagaagugag aguauuuauu uuuggcaugu uuggcccacc acacagacuc     3720

ugugugugua uguguguguu uauaugugua ugugugugac agaaaaaucu guagagaaga     3780

ggcacaucua uggcuacugu ucaaauacau aaagauaaau uuauuuucac acaguccaca     3840

agggguauau cuuguaguuu ucagaaaagc cuuuggaaau cuggaucaga aaauagauac     3900

caugguuugu gcaauuaugu aguaaaaaag gcaaaucuuu ucaccucugg cuauuccuga     3960

gaccccagga agucaggaaa agccuuucag cucacccaug gcugcuguga cuccuaccag     4020

ggcuuucuug gcuuuggcga aggucagugu acagacauuc caugguacca gagugcucag     4080

aaacucaaga uaggauaugc cucacccuca gcuacuccuu guuuuaaagu ucagcucuuu     4140

gaguaacuuc uucaauuucu uucaggacac uuggguugaa uucaguaagu uuccucugaa     4200

gcacccugaa gggugccauc cuuacagagc uaaguggaga cguuuccaga ucagcccaag     4260

uuuacuauag agacuggccc aggcacugaa ugucuaggac augcugugga ugaagauaaa     4320

gaugguggaa uagguuuuau cacaucucuu auuucucuuu uccccuuacu cucuaccauu     4380

uccuuuaugu ggggaaacau uuuaagguaa uaaauagguu acuuaccauc auauguucau     4440

auagaugaaa cuaauuuuug gcuuaaguca gaacaacugg ccaaaauuga agucauauuu     4500

gaggggggaa auggcauacg caauauuaua uuauauugga uauuuauguu cacacaggaa     4560

uuugguuuac ugcuuuguaa auaaaaggaa aaacuccggg uauauguaua gauguucuuc     4620

auuauagaca ucuucuuugc uuuucuuggc cuugggggag gaagggagaa gugcucuuuu     4680

cuacuugugg ggucucccau uggaaacaua auccuauagu cccagaagga uucagucccc     4740

aguggcuuuc ccauccaaag agaaagaguu ugaguuucuu aacucugcug uucugccacu     4800

uacucccacu agacaaccag ggacaaggug caacauggaa guguuugacu uaaguaggag     4860

cagaggagcu gcaucuaauc ucaucauacc uggaacuuga cacacuuaag caaaugccuu     4920

cccaucccua ccugccagau gcccccaacu caaugaaguu ggaugucuca ccagcuugau     4980

acccuuugaa uuuucaguca gacauucugg aguucuagca uccuguaccu aggaccuucc     5040

ucugugucac ucuuggccuc cuaaacucua agaaaauaac uauauucugg agcuugggca     5100

guguguuuug cauaauccag caaucuccuc augacaugca uguguugaua guccugaaac     5160

auucauugag aggguaaaug caguugaccu agaaugacca auaccaaaca gaauuuuaag     5220

aacagguggc caacuccuau ggagcuuacu cacauauuac uauucuuuua agaacggaaa     5280

guaaaauuau uuuugacuga agaaaaauga ugacagugaa aaacauggaa auguacucaa     5340

aacaagugac uuuuucugua accuuccaaa gaaacugaau uuuccaagga auuaaaugau     5400

aacaguggcu aaggcauagu uucuaaacuu ucaguaagau ccuggcauuc acagaaaaaa     5460

augaugaaug gggucuggac auacagccug agaucucaaa augacaauga aauucacaac     5520

uuuuucucag agacauucau guuuccugca uaugcuacaa cugcaguuug aaagaggcag     5580

caaugggagc aacccuuuac aagaaacaaa uugugauaua uucauguguu ggacggcagu     5640

aaauaagaug aaaccugagg agucagaucc accuuccccc auucauagag gcuuuucagc     5700

cucauuuuga gguacaguua cauaucuuuu gccuuuugcc cccgugcaua gcuaucuaca     5760

gccaaucaca gaucacagag ucacuggacu auagagcugg aaggaagcuc agagacaaug     5820

ccaagggggc agaaaauuua ucagaagcca gucccagugc guuuccucca uuuccuucug     5880

caggaagacu auuuugggcu gccugaacau uguaucaaac cugcuaccua uacuaugguc     5940

uaccuuuccu ccaguggaau uacaaaggca cuaacugaaa ugccuucuag aaacagagaa     6000

aacgaaacug uacuuauuua cucuugauac acagauuauu uauaaaacag auugaaguaa     6060

ccuguuaacu ggcaaaaaga gaaugagauc ggauuuaaau guauggcagu aaguccuauu     6120

gaucccucca guuaucucag uaugacugca guauauucau ucacuaaaac cacucacuag     6180

auaccaacua cacaccuggc acugcagaug uaaaggucag ucacacaugu ucugacuuua     6240

cagaguucac aguagcagug gaggaugaua uauguggaaa caaaaaaggc auugauucua     6300

uucagagcac uguuagggcu caaaggagag aggggucuuu ccaccuaaga aaugaggaau     6360

agggucauca uagaagugac cuuaagucuu aaaaauuaag aaggggauuc caagcugcuu     6420

cagacagaga cacaucgagc uaaaacacag agguaugaaa gagcacaggg acuuuaggaa     6480

uugcacaguu cauucuaaca ggaacaaaag gcucaagggg ggcaagaaau gaggcuguau     6540

ggaaagagau ucaauguaag cacuuuauaa aauagauuaa uuucugauuc aaugaagcau     6600

uucuugauca uuguguacaa ggcacuacau gcaucaugga aaauucauua ggaugcauug     6660

ccagcacuuu gcagaacuga uauuauucag ccucaagcuu uccaguggcc aaagggaaau     6720

gcugacugcu uuucauauau uugagucaaa gauuuuuuau auggucaaug aagacuaaua     6780

uaagggcagu gggauuuuca cagaugcaug ccauguuguc gagagccucu uagauuuucu     6840

caacugugag aaagaaaaac gaaaauguug aagacguuga gucuggagag gggauacuaa     6900

ucacugucca guugggcacu ggugggaaug gggaaauggc acaggaaugc aagccucucc     6960

acccuacccc ccgaacucca gccauacacu caucguuuca caaaauauaa augaguuagc     7020

auuaaauguu ucagaguaaa uaauuccuuu ucccgaaaug caugaagaua gaguaacaga     7080

cuucucacac uguauuuuua ggguauggag aauuuagaag guuaaagaau uacugcuuca     7140

auuuuucagu uaaaaaaaaa ucaggaagcu cuguucauuc aggcuaugca ccaugugcac     7200

agucaagaau uagcagaaac ccucugcauu uacaaacacu uugugcuaua aaaaaguaau     7260

uuuuaaaaag ccacgugugu guguguguau auauauauau auauauauau uuaaagccaa     7320

gguuuugaua cuuuuuuaca aaaacuacaa gagaaaacaa auauaccugu ccaaaccaua     7380

uacuuuuaaa agagcauuuu uuuuuccaua caagcuguug uuaauuuggg gguaaagugc     7440

ugauuugcaa acuucaucaa auuguuccca aguggauucu ccuuguuugu cucccccuac     7500

caaccccaaa guuaccauau uugauguaag aaucaggcau guuagaaugu ugugucacac     7560

uaacugauuc ugcucuuuuu gucuugucau ucaaguuccg uuagcuucug uacgcggugc     7620

ccuuugcagu cuggugucuc uuccagaggc gagggggcug aggauggggu gcugcaucuc     7680

acuagcuaua cuggcaucau cuugguaaac ugaaaaccaa auguggacau uuguaaaauc     7740

agugcacugu uucuagagag agauuaaauu cauuuaaaaa aaa                       7783


<210>  12
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gly Leu Pro Glu Pro Gly Pro Leu Arg Leu Leu Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Gln Leu Gln His Leu Ala Ala Ala 
            20                  25                  30          


Ala Ala Asp Pro Leu Leu Gly Gly Gln Gly Pro Ala Lys Asp Cys Glu 
        35                  40                  45              


Lys Asp Gln Phe Gln Cys Arg Asn Glu Arg Cys Ile Pro Ser Val Trp 
    50                  55                  60                  


Arg Cys Asp Glu Asp Asp Asp Cys Leu Asp His Ser Asp Glu Asp Asp 
65                  70                  75                  80  


Cys Pro Lys Lys Thr Cys Ala Asp Ser Asp Phe Thr Cys Asp Asn Gly 
                85                  90                  95      


His Cys Ile His Glu Arg Trp Lys Cys Asp Gly Glu Glu Glu Cys Pro 
            100                 105                 110         


Asp Gly Ser Asp Glu Ser Glu Ala Thr Cys Thr Lys Gln Val Cys Pro 
        115                 120                 125             


Ala Glu Lys Leu Ser Cys Gly Pro Thr Ser His Lys Cys Val Pro Ala 
    130                 135                 140                 


Ser Trp Arg Cys Asp Gly Glu Lys Asp Cys Glu Gly Gly Ala Asp Glu 
145                 150                 155                 160 


Ala Gly Cys Ala Thr Leu Cys Ala Pro His Glu Phe Gln Cys Gly Asn 
                165                 170                 175     


Arg Ser Cys Leu Ala Ala Val Phe Val Cys Asp Gly Asp Asp Asp Cys 
            180                 185                 190         


Gly Asp Gly Ser Asp Glu Arg Gly Cys Ala Asp Pro Ala Cys Gly Pro 
        195                 200                 205             


Arg Glu Phe Arg Cys Gly Gly Asp Gly Gly Gly Ala Cys Ile Pro Glu 
    210                 215                 220                 


Arg Trp Val Cys Asp Arg Gln Phe Asp Cys Glu Asp Arg Ser Asp Glu 
225                 230                 235                 240 


Ala Ala Glu Leu Cys Gly Arg Pro Gly Pro Gly Ala Thr Ser Ala Pro 
                245                 250                 255     


Ala Ala Cys Ala Thr Ala Ser Gln Phe Ala Cys Arg Ser Gly Glu Cys 
            260                 265                 270         


Val His Leu Gly Trp Arg Cys Asp Gly Asp Arg Asp Cys Lys Asp Lys 
        275                 280                 285             


Ser Asp Glu Ala Asp Cys Pro Leu Gly Thr Cys Arg Gly Asp Glu Phe 
    290                 295                 300                 


Gln Cys Gly Asp Gly Thr Cys Val Leu Ala Ile Lys His Cys Asn Gln 
305                 310                 315                 320 


Glu Gln Asp Cys Pro Asp Gly Ser Asp Glu Ala Gly Cys Leu Gln Gly 
                325                 330                 335     


Leu Asn Glu Cys Leu His Asn Asn Gly Gly Cys Ser His Ile Cys Thr 
            340                 345                 350         


Asp Leu Lys Ile Gly Phe Glu Cys Thr Cys Pro Ala Gly Phe Gln Leu 
        355                 360                 365             


Leu Asp Gln Lys Thr Cys Gly Asp Ile Asp Glu Cys Lys Asp Pro Asp 
    370                 375                 380                 


Ala Cys Ser Gln Ile Cys Val Asn Tyr Lys Gly Tyr Phe Lys Cys Glu 
385                 390                 395                 400 


Cys Tyr Pro Gly Tyr Glu Met Asp Leu Leu Thr Lys Asn Cys Lys Ala 
                405                 410                 415     


Ala Ala Gly Lys Ser Pro Ser Leu Ile Phe Thr Asn Arg His Glu Val 
            420                 425                 430         


Arg Arg Ile Asp Leu Val Lys Arg Asn Tyr Ser Arg Leu Ile Pro Met 
        435                 440                 445             


Leu Lys Asn Val Val Ala Leu Asp Val Glu Val Ala Thr Asn Arg Ile 
    450                 455                 460                 


Tyr Trp Cys Asp Leu Ser Tyr Arg Lys Ile Tyr Ser Ala Tyr Met Asp 
465                 470                 475                 480 


Lys Ala Ser Asp Pro Lys Glu Gln Glu Val Leu Ile Asp Glu Gln Leu 
                485                 490                 495     


His Ser Pro Glu Gly Leu Ala Val Asp Trp Val His Lys His Ile Tyr 
            500                 505                 510         


Trp Thr Asp Ser Gly Asn Lys Thr Ile Ser Val Ala Thr Val Asp Gly 
        515                 520                 525             


Gly Arg Arg Arg Thr Leu Phe Ser Arg Asn Leu Ser Glu Pro Arg Ala 
    530                 535                 540                 


Ile Ala Val Asp Pro Leu Arg Gly Phe Met Tyr Trp Ser Asp Trp Gly 
545                 550                 555                 560 


Asp Gln Ala Lys Ile Glu Lys Ser Gly Leu Asn Gly Val Asp Arg Gln 
                565                 570                 575     


Thr Leu Val Ser Asp Asn Ile Glu Trp Pro Asn Gly Ile Thr Leu Asp 
            580                 585                 590         


Leu Leu Ser Gln Arg Leu Tyr Trp Val Asp Ser Lys Leu His Gln Leu 
        595                 600                 605             


Ser Ser Ile Asp Phe Ser Gly Gly Asn Arg Lys Thr Leu Ile Ser Ser 
    610                 615                 620                 


Thr Asp Phe Leu Ser His Pro Phe Gly Ile Ala Val Phe Glu Asp Lys 
625                 630                 635                 640 


Val Phe Trp Thr Asp Leu Glu Asn Glu Ala Ile Phe Ser Ala Asn Arg 
                645                 650                 655     


Leu Asn Gly Leu Glu Ile Ser Ile Leu Ala Glu Asn Leu Asn Asn Pro 
            660                 665                 670         


His Asp Ile Val Ile Phe His Glu Leu Lys Gln Pro Arg Ala Pro Asp 
        675                 680                 685             


Ala Cys Glu Leu Ser Val Gln Pro Asn Gly Gly Cys Glu Tyr Leu Cys 
    690                 695                 700                 


Leu Pro Ala Pro Gln Ile Ser Ser His Ser Pro Lys Tyr Thr Cys Ala 
705                 710                 715                 720 


Cys Pro Asp Thr Met Trp Leu Gly Pro Asp Met Lys Arg Cys Tyr Arg 
                725                 730                 735     


Ala Pro Gln Ser Thr Ser Thr Thr Thr Leu Ala Ser Thr Met Thr Arg 
            740                 745                 750         


Thr Val Pro Ala Thr Thr Arg Ala Pro Gly Thr Thr Val His Arg Ser 
        755                 760                 765             


Thr Tyr Gln Asn His Ser Thr Glu Thr Pro Ser Leu Thr Ala Ala Val 
    770                 775                 780                 


Pro Ser Ser Val Ser Val Pro Arg Ala Pro Ser Ile Ser Pro Ser Thr 
785                 790                 795                 800 


Leu Ser Pro Ala Thr Ser Asn His Ser Gln His Tyr Ala Asn Glu Asp 
                805                 810                 815     


Ser Lys Met Gly Ser Thr Val Thr Ala Ala Val Ile Gly Ile Ile Val 
            820                 825                 830         


Pro Ile Val Val Ile Ala Leu Leu Cys Met Ser Gly Tyr Leu Ile Trp 
        835                 840                 845             


Arg Asn Trp Lys Arg Lys Asn Thr Lys Ser Met Asn Phe Asp Asn Pro 
    850                 855                 860                 


Val Tyr Arg Lys Thr Thr Glu Glu Glu Asp Glu Asp Glu Leu His Ile 
865                 870                 875                 880 


Gly Arg Thr Ala Gln Ile Gly His Val Tyr Pro Ala Ala Ile Ser Ser 
                885                 890                 895     


Phe Asp Arg Pro Leu Trp Ala Glu Pro Cys Leu Gly Glu Thr Arg Glu 
            900                 905                 910         


Pro Glu Asp Pro Ala Pro Ala Leu Lys Glu Leu Phe Val Leu Pro Gly 
        915                 920                 925             


Glu Pro Arg Ser Gln Leu His Gln Leu Pro Lys Asn Pro Leu Ser Glu 
    930                 935                 940                 


Leu Pro Val Val Lys Ser Lys Arg Val Ala Leu Ser Leu Glu Asp Asp 
945                 950                 955                 960 


Gly Leu Pro 
            


<210>  13
<211>  7273
<212>  RNA
<213>  Homo sapiens

<400>  13
gcuggcggcg gccgcccagg gccggggccg cgcgcccagc cugagcccgc cccgccgccg       60

agcgucaccg aaccugcuug aaaugcagcc gaggagccgg ggcgggcggc agcggcggcg      120

gcggcggcgg cgggggcagc ggcaaccccg gcgccgcggc aaggacucgg agggcugaga      180

cgcggcggcg gcggcgcggg gagcgcgggg cgcggcggcc ggagccccgg gcccgccaug      240

ggccuccccg agccgggccc ucuccggcuu cuggcgcugc ugcugcugcu gcugcugcug      300

cugcugcugc agcuccagca ucuugcggcg gcagcggcug auccgcugcu cggcggccaa      360

gggccggcca aggauugcga aaaggaccaa uuccagugcc ggaacgagcg cugcaucccc      420

ucugugugga gaugcgacga ggacgaugac ugcuuagacc acagcgacga ggacgacugc      480

cccaagaaga ccugugcaga cagugacuuc accugugaca acggccacug cauccacgaa      540

cgguggaagu gugacggcga ggaggagugu ccugauggcu ccgaugaguc cgaggccacu      600

ugcaccaagc aggugugucc ugcagagaag cugagcugug gacccaccag ccacaagugu      660

guaccugccu cguggcgcug cgacggggag aaggacugcg aggguggagc ggaugaggcc      720

ggcugugcua ccuggcugaa cgagugucug cacaacaaug gcggcugcuc acacaucugc      780

acugaccuca agauuggcuu ugaaugcacg ugcccagcag gcuuccagcu ccuggaccag      840

aagaccugug gcgacauuga ugagugcaag gacccagaug ccugcagcca gaucuguguc      900

aauuacaagg gcuauuuuaa gugugagugc uacccuggcu acgagaugga ccuacugacc      960

aagaacugca aggcugcugc uggcaagagc ccaucccuaa ucuucaccaa ccggcacgag     1020

gugcggagga ucgaccuggu gaagcggaac uauucacgcc ucauccccau gcucaagaau     1080

gucguggcac uagaugugga aguugccacc aaucgcaucu acugguguga ccucuccuac     1140

cguaagaucu auagcgccua cauggacaag gccagugacc cgaaagagca ggagguccuc     1200

auugacgagc aguugcacuc uccagagggc cuggcagugg acugggucca caagcacauc     1260

uacuggacug acucgggcaa uaagaccauc ucaguggcca caguugaugg uggccgccga     1320

cgcacucucu ucagccguaa ccucagugaa ccccgggcca ucgcuguuga cccccugcga     1380

ggguucaugu auuggucuga cuggggggac caggccaaga uugagaaauc ugggcucaac     1440

gguguggacc ggcaaacacu ggugucagac aauauugaau ggcccaacgg aaucacccug     1500

gaucugcuga gccagcgcuu guacugggua gacuccaagc uacaccaacu guccagcauu     1560

gacuucagug gaggcaacag aaagacgcug aucuccucca cugacuuccu gagccacccu     1620

uuugggauag cuguguuuga ggacaaggug uucuggacag accuggagaa cgaggccauu     1680

uucagugcaa aucggcucaa uggccuggaa aucuccaucc uggcugagaa ccucaacaac     1740

ccacaugaca uugucaucuu ccaugagcug aagcagccaa gagcuccaga ugccugugag     1800

cugagugucc agccuaaugg aggcugugaa uaccugugcc uuccugcucc ucagaucucc     1860

agccacucuc ccaaguacac augugccugu ccugacacaa uguggcuggg uccagacaug     1920

aagaggugcu accgagcacc ucaaucuacc ucaacuacga cguuagcuuc uaccaugacg     1980

aggacaguac cugccaccac aagagccccc gggaccaccg uccacagauc caccuaccag     2040

aaccacagca cagagacacc aagccugaca gcugcagucc caagcucagu uagugucccc     2100

agggcuccca gcaucagccc gucuacccua agcccugcaa ccagcaacca cucccagcac     2160

uaugcaaaug aagacaguaa gaugggcuca acagucacug ccgcuguuau cgggaucauc     2220

gugcccauag uggugauagc ccuccugugc augaguggau accugaucug gagaaacugg     2280

aagcggaaga acaccaaaag caugaauuuu gacaacccag ucuacaggaa aacaacagaa     2340

gaagaagacg aagaugagcu ccauauaggg agaacugcuc agauuggcca ugucuauccu     2400

gcagcaauca gcagcuuuga ucgcccacug ugggcagagc ccugucuugg ggagaccaga     2460

gaaccggaag acccagcccc ugcccucaag gagcuuuuug ucuugccggg ggaaccaagg     2520

ucacagcugc accaacuccc gaagaacccu cuuuccgagc ugccugucgu caaauccaag     2580

cgaguggcau uaagccuuga agaugaugga cuacccugag gaugggauca cccccuucgu     2640

gccucaugga auucaguccc augcacuaca cucuggaugg uguaugacug gaugaauggg     2700

uuucuauaua ugggucugug ugaguguaug ugugugugug auuuuuuuuu uaaauuuaug     2760

uugcggaaag guaaccacaa aguuaugaug aacugcaaac auccaaagga ugugagaguu     2820

uuucuaugua uaauguuuua uacacuuuuu aacugguugc acuacccaug aggaauucgu     2880

ggaauggcua cugcugacua acaugaugca cauaaccaaa ugggggccaa uggcacagua     2940

ccuuacucau cauuuaaaaa cuauauuuac agaagauguu ugguugcugg gggggcuuuu     3000

uuagguuuug gggcauuugu uuuuuguaaa uaagaugauu augcuuugug gcuauccauc     3060

aacauaagua aaaaaaaaaa aaaaacacuu caacucccuc ccccauuuag auuauuuauu     3120

aacauauuuu aaaaaucaga ugaguucuau aaauaauuua gagaagugag aguauuuauu     3180

uuuggcaugu uuggcccacc acacagacuc ugugugugua uguguguguu uauaugugua     3240

ugugugugac agaaaaaucu guagagaaga ggcacaucua uggcuacugu ucaaauacau     3300

aaagauaaau uuauuuucac acaguccaca agggguauau cuuguaguuu ucagaaaagc     3360

cuuuggaaau cuggaucaga aaauagauac caugguuugu gcaauuaugu aguaaaaaag     3420

gcaaaucuuu ucaccucugg cuauuccuga gaccccagga agucaggaaa agccuuucag     3480

cucacccaug gcugcuguga cuccuaccag ggcuuucuug gcuuuggcga aggucagugu     3540

acagacauuc caugguacca gagugcucag aaacucaaga uaggauaugc cucacccuca     3600

gcuacuccuu guuuuaaagu ucagcucuuu gaguaacuuc uucaauuucu uucaggacac     3660

uuggguugaa uucaguaagu uuccucugaa gcacccugaa gggugccauc cuuacagagc     3720

uaaguggaga cguuuccaga ucagcccaag uuuacuauag agacuggccc aggcacugaa     3780

ugucuaggac augcugugga ugaagauaaa gaugguggaa uagguuuuau cacaucucuu     3840

auuucucuuu uccccuuacu cucuaccauu uccuuuaugu ggggaaacau uuuaagguaa     3900

uaaauagguu acuuaccauc auauguucau auagaugaaa cuaauuuuug gcuuaaguca     3960

gaacaacugg ccaaaauuga agucauauuu gaggggggaa auggcauacg caauauuaua     4020

uuauauugga uauuuauguu cacacaggaa uuugguuuac ugcuuuguaa auaaaaggaa     4080

aaacuccggg uauauguaua gauguucuuc auuauagaca ucuucuuugc uuuucuuggc     4140

cuugggggag gaagggagaa gugcucuuuu cuacuugugg ggucucccau uggaaacaua     4200

auccuauagu cccagaagga uucagucccc aguggcuuuc ccauccaaag agaaagaguu     4260

ugaguuucuu aacucugcug uucugccacu uacucccacu agacaaccag ggacaaggug     4320

caacauggaa guguuugacu uaaguaggag cagaggagcu gcaucuaauc ucaucauacc     4380

uggaacuuga cacacuuaag caaaugccuu cccaucccua ccugccagau gcccccaacu     4440

caaugaaguu ggaugucuca ccagcuugau acccuuugaa uuuucaguca gacauucugg     4500

aguucuagca uccuguaccu aggaccuucc ucugugucac ucuuggccuc cuaaacucua     4560

agaaaauaac uauauucugg agcuugggca guguguuuug cauaauccag caaucuccuc     4620

augacaugca uguguugaua guccugaaac auucauugag aggguaaaug caguugaccu     4680

agaaugacca auaccaaaca gaauuuuaag aacagguggc caacuccuau ggagcuuacu     4740

cacauauuac uauucuuuua agaacggaaa guaaaauuau uuuugacuga agaaaaauga     4800

ugacagugaa aaacauggaa auguacucaa aacaagugac uuuuucugua accuuccaaa     4860

gaaacugaau uuuccaagga auuaaaugau aacaguggcu aaggcauagu uucuaaacuu     4920

ucaguaagau ccuggcauuc acagaaaaaa augaugaaug gggucuggac auacagccug     4980

agaucucaaa augacaauga aauucacaac uuuuucucag agacauucau guuuccugca     5040

uaugcuacaa cugcaguuug aaagaggcag caaugggagc aacccuuuac aagaaacaaa     5100

uugugauaua uucauguguu ggacggcagu aaauaagaug aaaccugagg agucagaucc     5160

accuuccccc auucauagag gcuuuucagc cucauuuuga gguacaguua cauaucuuuu     5220

gccuuuugcc cccgugcaua gcuaucuaca gccaaucaca gaucacagag ucacuggacu     5280

auagagcugg aaggaagcuc agagacaaug ccaagggggc agaaaauuua ucagaagcca     5340

gucccagugc guuuccucca uuuccuucug caggaagacu auuuugggcu gccugaacau     5400

uguaucaaac cugcuaccua uacuaugguc uaccuuuccu ccaguggaau uacaaaggca     5460

cuaacugaaa ugccuucuag aaacagagaa aacgaaacug uacuuauuua cucuugauac     5520

acagauuauu uauaaaacag auugaaguaa ccuguuaacu ggcaaaaaga gaaugagauc     5580

ggauuuaaau guauggcagu aaguccuauu gaucccucca guuaucucag uaugacugca     5640

guauauucau ucacuaaaac cacucacuag auaccaacua cacaccuggc acugcagaug     5700

uaaaggucag ucacacaugu ucugacuuua cagaguucac aguagcagug gaggaugaua     5760

uauguggaaa caaaaaaggc auugauucua uucagagcac uguuagggcu caaaggagag     5820

aggggucuuu ccaccuaaga aaugaggaau agggucauca uagaagugac cuuaagucuu     5880

aaaaauuaag aaggggauuc caagcugcuu cagacagaga cacaucgagc uaaaacacag     5940

agguaugaaa gagcacaggg acuuuaggaa uugcacaguu cauucuaaca ggaacaaaag     6000

gcucaagggg ggcaagaaau gaggcuguau ggaaagagau ucaauguaag cacuuuauaa     6060

aauagauuaa uuucugauuc aaugaagcau uucuugauca uuguguacaa ggcacuacau     6120

gcaucaugga aaauucauua ggaugcauug ccagcacuuu gcagaacuga uauuauucag     6180

ccucaagcuu uccaguggcc aaagggaaau gcugacugcu uuucauauau uugagucaaa     6240

gauuuuuuau auggucaaug aagacuaaua uaagggcagu gggauuuuca cagaugcaug     6300

ccauguuguc gagagccucu uagauuuucu caacugugag aaagaaaaac gaaaauguug     6360

aagacguuga gucuggagag gggauacuaa ucacugucca guugggcacu ggugggaaug     6420

gggaaauggc acaggaaugc aagccucucc acccuacccc ccgaacucca gccauacacu     6480

caucguuuca caaaauauaa augaguuagc auuaaauguu ucagaguaaa uaauuccuuu     6540

ucccgaaaug caugaagaua gaguaacaga cuucucacac uguauuuuua ggguauggag     6600

aauuuagaag guuaaagaau uacugcuuca auuuuucagu uaaaaaaaaa ucaggaagcu     6660

cuguucauuc aggcuaugca ccaugugcac agucaagaau uagcagaaac ccucugcauu     6720

uacaaacacu uugugcuaua aaaaaguaau uuuuaaaaag ccacgugugu guguguguau     6780

auauauauau auauauauau uuaaagccaa gguuuugaua cuuuuuuaca aaaacuacaa     6840

gagaaaacaa auauaccugu ccaaaccaua uacuuuuaaa agagcauuuu uuuuuccaua     6900

caagcuguug uuaauuuggg gguaaagugc ugauuugcaa acuucaucaa auuguuccca     6960

aguggauucu ccuuguuugu cucccccuac caaccccaaa guuaccauau uugauguaag     7020

aaucaggcau guuagaaugu ugugucacac uaacugauuc ugcucuuuuu gucuugucau     7080

ucaaguuccg uuagcuucug uacgcggugc ccuuugcagu cuggugucuc uuccagaggc     7140

gagggggcug aggauggggu gcugcaucuc acuagcuaua cuggcaucau cuugguaaac     7200

ugaaaaccaa auguggacau uuguaaaauc agugcacugu uucuagagag agauuaaauu     7260

cauuuaaaaa aaa                                                        7273


<210>  14
<211>  793
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gly Leu Pro Glu Pro Gly Pro Leu Arg Leu Leu Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Gln Leu Gln His Leu Ala Ala Ala 
            20                  25                  30          


Ala Ala Asp Pro Leu Leu Gly Gly Gln Gly Pro Ala Lys Asp Cys Glu 
        35                  40                  45              


Lys Asp Gln Phe Gln Cys Arg Asn Glu Arg Cys Ile Pro Ser Val Trp 
    50                  55                  60                  


Arg Cys Asp Glu Asp Asp Asp Cys Leu Asp His Ser Asp Glu Asp Asp 
65                  70                  75                  80  


Cys Pro Lys Lys Thr Cys Ala Asp Ser Asp Phe Thr Cys Asp Asn Gly 
                85                  90                  95      


His Cys Ile His Glu Arg Trp Lys Cys Asp Gly Glu Glu Glu Cys Pro 
            100                 105                 110         


Asp Gly Ser Asp Glu Ser Glu Ala Thr Cys Thr Lys Gln Val Cys Pro 
        115                 120                 125             


Ala Glu Lys Leu Ser Cys Gly Pro Thr Ser His Lys Cys Val Pro Ala 
    130                 135                 140                 


Ser Trp Arg Cys Asp Gly Glu Lys Asp Cys Glu Gly Gly Ala Asp Glu 
145                 150                 155                 160 


Ala Gly Cys Ala Thr Trp Leu Asn Glu Cys Leu His Asn Asn Gly Gly 
                165                 170                 175     


Cys Ser His Ile Cys Thr Asp Leu Lys Ile Gly Phe Glu Cys Thr Cys 
            180                 185                 190         


Pro Ala Gly Phe Gln Leu Leu Asp Gln Lys Thr Cys Gly Asp Ile Asp 
        195                 200                 205             


Glu Cys Lys Asp Pro Asp Ala Cys Ser Gln Ile Cys Val Asn Tyr Lys 
    210                 215                 220                 


Gly Tyr Phe Lys Cys Glu Cys Tyr Pro Gly Tyr Glu Met Asp Leu Leu 
225                 230                 235                 240 


Thr Lys Asn Cys Lys Ala Ala Ala Gly Lys Ser Pro Ser Leu Ile Phe 
                245                 250                 255     


Thr Asn Arg His Glu Val Arg Arg Ile Asp Leu Val Lys Arg Asn Tyr 
            260                 265                 270         


Ser Arg Leu Ile Pro Met Leu Lys Asn Val Val Ala Leu Asp Val Glu 
        275                 280                 285             


Val Ala Thr Asn Arg Ile Tyr Trp Cys Asp Leu Ser Tyr Arg Lys Ile 
    290                 295                 300                 


Tyr Ser Ala Tyr Met Asp Lys Ala Ser Asp Pro Lys Glu Gln Glu Val 
305                 310                 315                 320 


Leu Ile Asp Glu Gln Leu His Ser Pro Glu Gly Leu Ala Val Asp Trp 
                325                 330                 335     


Val His Lys His Ile Tyr Trp Thr Asp Ser Gly Asn Lys Thr Ile Ser 
            340                 345                 350         


Val Ala Thr Val Asp Gly Gly Arg Arg Arg Thr Leu Phe Ser Arg Asn 
        355                 360                 365             


Leu Ser Glu Pro Arg Ala Ile Ala Val Asp Pro Leu Arg Gly Phe Met 
    370                 375                 380                 


Tyr Trp Ser Asp Trp Gly Asp Gln Ala Lys Ile Glu Lys Ser Gly Leu 
385                 390                 395                 400 


Asn Gly Val Asp Arg Gln Thr Leu Val Ser Asp Asn Ile Glu Trp Pro 
                405                 410                 415     


Asn Gly Ile Thr Leu Asp Leu Leu Ser Gln Arg Leu Tyr Trp Val Asp 
            420                 425                 430         


Ser Lys Leu His Gln Leu Ser Ser Ile Asp Phe Ser Gly Gly Asn Arg 
        435                 440                 445             


Lys Thr Leu Ile Ser Ser Thr Asp Phe Leu Ser His Pro Phe Gly Ile 
    450                 455                 460                 


Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Leu Glu Asn Glu Ala 
465                 470                 475                 480 


Ile Phe Ser Ala Asn Arg Leu Asn Gly Leu Glu Ile Ser Ile Leu Ala 
                485                 490                 495     


Glu Asn Leu Asn Asn Pro His Asp Ile Val Ile Phe His Glu Leu Lys 
            500                 505                 510         


Gln Pro Arg Ala Pro Asp Ala Cys Glu Leu Ser Val Gln Pro Asn Gly 
        515                 520                 525             


Gly Cys Glu Tyr Leu Cys Leu Pro Ala Pro Gln Ile Ser Ser His Ser 
    530                 535                 540                 


Pro Lys Tyr Thr Cys Ala Cys Pro Asp Thr Met Trp Leu Gly Pro Asp 
545                 550                 555                 560 


Met Lys Arg Cys Tyr Arg Ala Pro Gln Ser Thr Ser Thr Thr Thr Leu 
                565                 570                 575     


Ala Ser Thr Met Thr Arg Thr Val Pro Ala Thr Thr Arg Ala Pro Gly 
            580                 585                 590         


Thr Thr Val His Arg Ser Thr Tyr Gln Asn His Ser Thr Glu Thr Pro 
        595                 600                 605             


Ser Leu Thr Ala Ala Val Pro Ser Ser Val Ser Val Pro Arg Ala Pro 
    610                 615                 620                 


Ser Ile Ser Pro Ser Thr Leu Ser Pro Ala Thr Ser Asn His Ser Gln 
625                 630                 635                 640 


His Tyr Ala Asn Glu Asp Ser Lys Met Gly Ser Thr Val Thr Ala Ala 
                645                 650                 655     


Val Ile Gly Ile Ile Val Pro Ile Val Val Ile Ala Leu Leu Cys Met 
            660                 665                 670         


Ser Gly Tyr Leu Ile Trp Arg Asn Trp Lys Arg Lys Asn Thr Lys Ser 
        675                 680                 685             


Met Asn Phe Asp Asn Pro Val Tyr Arg Lys Thr Thr Glu Glu Glu Asp 
    690                 695                 700                 


Glu Asp Glu Leu His Ile Gly Arg Thr Ala Gln Ile Gly His Val Tyr 
705                 710                 715                 720 


Pro Ala Ala Ile Ser Ser Phe Asp Arg Pro Leu Trp Ala Glu Pro Cys 
                725                 730                 735     


Leu Gly Glu Thr Arg Glu Pro Glu Asp Pro Ala Pro Ala Leu Lys Glu 
            740                 745                 750         


Leu Phe Val Leu Pro Gly Glu Pro Arg Ser Gln Leu His Gln Leu Pro 
        755                 760                 765             


Lys Asn Pro Leu Ser Glu Leu Pro Val Val Lys Ser Lys Arg Val Ala 
    770                 775                 780                 


Leu Ser Leu Glu Asp Asp Gly Leu Pro 
785                 790             


<210>  15
<211>  6994
<212>  RNA
<213>  Homo sapiens

<400>  15
gcuggcggcg gccgcccagg gccggggccg cgcgcccagc cugagcccgc cccgccgccg       60

agcgucaccg aaccugcuug aaaugcagcc gaggagccgg ggcgggcggc agcggcggcg      120

gcggcggcgg cgggggcagc ggcaaccccg gcgccgcggc aaggacucgg agggcugaga      180

cgcggcggcg gcggcgcggg gagcgcgggg cgcggcggcc ggagccccgg gcccgccaug      240

ggccuccccg agccgggccc ucuccggcuu cuggcgcugc ugcugcugcu gcugcugcug      300

cugcugcugc agcuccagca ucuugcggcg gcagcggcug auccgcugcu cggcggccaa      360

gggccggcca aggauugcga aaaggaccaa uuccagugcc ggaacgagcg cugcaucccc      420

ucugugugga gaugcgacga ggacgaugac ugcuuagacc acagcgacga ggacgacugc      480

cccaagaaga ccugugcaga cagugacuuc accugugaca acggccacug cauccacgaa      540

cgguggaagu gugacggcga ggaggagugu ccugauggcu ccgaugaguc cgaggccacu      600

ugcaccaagc aggugugucc ugcagagaag cugagcugug gacccaccag ccacaagugu      660

guaccugccu cguggcgcug cgacggggag aaggacugcg aggguggagc ggaugaggcc      720

ggcugugcua ccucacuggg caccugccgu ggggacgagu uccagugugg ggaugggaca      780

uguguccuug caaucaagca cugcaaccag gagcaggacu guccagaugg gagugaugaa      840

gcuggcugcc uacaggggcu gaacgagugu cugcacaaca auggcggcug cucacacauc      900

ugcacugacc ucaagauugg cuuugaaugc acgugcccag caggcuucca gcuccuggac      960

cagaagaccu guggcgacau ugaugagugc aaggacccag augccugcag ccagaucugu     1020

gucaauuaca agggcuauuu uaagugugag ugcuacccug gcuacgagau ggaccuacug     1080

accaagaacu gcaaggcugc ugcuggcaag agcccauccc uaaucuucac caaccggcac     1140

gaggugcgga ggaucgaccu ggugaagcgg aacuauucac gccucauccc caugcucaag     1200

aaugucgugg cacuagaugu ggaaguugcc accaaucgca ucuacuggug ugaccucucc     1260

uaccguaaga ucuauagcgc cuacauggac aaggccagug acccgaaaga gcaggagguc     1320

cucauugacg agcaguugca cucuccagag ggccuggcag uggacugggu ccacaagcac     1380

aucuacugga cugacucggg caauaagacc aucucagugg ccacaguuga ugguggccgc     1440

cgacgcacuc ucuucagccg uaaccucagu gaaccccggg ccaucgcugu ugacccccug     1500

cgaggguuca uguauugguc ugacuggggg gaccaggcca agauugagaa aucugggcuc     1560

aacggugugg accggcaaac acugguguca gacaauauug aauggcccaa cggaaucacc     1620

cuggaucugc ugagccagcg cuuguacugg guagacucca agcuacacca acuguccagc     1680

auugacuuca guggaggcaa cagaaagacg cugaucuccu ccacugacuu ccugagccac     1740

ccuuuuggga uagcuguguu ugaggacaag guguucugga cagaccugga gaacgaggcc     1800

auuuucagug caaaucggcu caauggccug gaaaucucca uccuggcuga gaaccucaac     1860

aacccacaug acauugucau cuuccaugag cugaagcagc caagagcucc agaugccugu     1920

gagcugagug uccagccuaa uggaggcugu gaauaccugu gccuuccugc uccucagauc     1980

uccagccacu cucccaagua cacaugugcc uguccugaca caauguggcu ggguccagac     2040

augaagaggu gcuaccgaga ugcaaaugaa gacaguaaga ugggcucaac agucacugcc     2100

gcuguuaucg ggaucaucgu gcccauagug gugauagccc uccugugcau gaguggauac     2160

cugaucugga gaaacuggaa gcggaagaac accaaaagca ugaauuuuga caacccaguc     2220

uacaggaaaa caacagaaga agaagacgaa gaugagcucc auauagggag aacugcucag     2280

auuggccaug ucuauccugc acgaguggca uuaagccuug aagaugaugg acuacccuga     2340

ggaugggauc acccccuucg ugccucaugg aauucagucc caugcacuac acucuggaug     2400

guguaugacu ggaugaaugg guuucuauau augggucugu gugaguguau gugugugugu     2460

gauuuuuuuu uuaaauuuau guugcggaaa gguaaccaca aaguuaugau gaacugcaaa     2520

cauccaaagg augugagagu uuuucuaugu auaauguuuu auacacuuuu uaacugguug     2580

cacuacccau gaggaauucg uggaauggcu acugcugacu aacaugaugc acauaaccaa     2640

augggggcca auggcacagu accuuacuca ucauuuaaaa acuauauuua cagaagaugu     2700

uugguugcug ggggggcuuu uuuagguuuu ggggcauuug uuuuuuguaa auaagaugau     2760

uaugcuuugu ggcuauccau caacauaagu aaaaaaaaaa aaaaaacacu ucaacucccu     2820

cccccauuua gauuauuuau uaacauauuu uaaaaaucag augaguucua uaaauaauuu     2880

agagaaguga gaguauuuau uuuuggcaug uuuggcccac cacacagacu cugugugugu     2940

augugugugu uuauaugugu auguguguga cagaaaaauc uguagagaag aggcacaucu     3000

auggcuacug uucaaauaca uaaagauaaa uuuauuuuca cacaguccac aagggguaua     3060

ucuuguaguu uucagaaaag ccuuuggaaa ucuggaucag aaaauagaua ccaugguuug     3120

ugcaauuaug uaguaaaaaa ggcaaaucuu uucaccucug gcuauuccug agaccccagg     3180

aagucaggaa aagccuuuca gcucacccau ggcugcugug acuccuacca gggcuuucuu     3240

ggcuuuggcg aaggucagug uacagacauu ccaugguacc agagugcuca gaaacucaag     3300

auaggauaug ccucacccuc agcuacuccu uguuuuaaag uucagcucuu ugaguaacuu     3360

cuucaauuuc uuucaggaca cuuggguuga auucaguaag uuuccucuga agcacccuga     3420

agggugccau ccuuacagag cuaaguggag acguuuccag aucagcccaa guuuacuaua     3480

gagacuggcc caggcacuga augucuagga caugcugugg augaagauaa agauggugga     3540

auagguuuua ucacaucucu uauuucucuu uuccccuuac ucucuaccau uuccuuuaug     3600

uggggaaaca uuuuaaggua auaaauaggu uacuuaccau cauauguuca uauagaugaa     3660

acuaauuuuu ggcuuaaguc agaacaacug gccaaaauug aagucauauu ugagggggga     3720

aauggcauac gcaauauuau auuauauugg auauuuaugu ucacacagga auuugguuua     3780

cugcuuugua aauaaaagga aaaacuccgg guauauguau agauguucuu cauuauagac     3840

aucuucuuug cuuuucuugg ccuuggggga ggaagggaga agugcucuuu ucuacuugug     3900

gggucuccca uuggaaacau aauccuauag ucccagaagg auucaguccc caguggcuuu     3960

cccauccaaa gagaaagagu uugaguuucu uaacucugcu guucugccac uuacucccac     4020

uagacaacca gggacaaggu gcaacaugga aguguuugac uuaaguagga gcagaggagc     4080

ugcaucuaau cucaucauac cuggaacuug acacacuuaa gcaaaugccu ucccaucccu     4140

accugccaga ugcccccaac ucaaugaagu uggaugucuc accagcuuga uacccuuuga     4200

auuuucaguc agacauucug gaguucuagc auccuguacc uaggaccuuc cucuguguca     4260

cucuuggccu ccuaaacucu aagaaaauaa cuauauucug gagcuugggc aguguguuuu     4320

gcauaaucca gcaaucuccu caugacaugc auguguugau aguccugaaa cauucauuga     4380

gaggguaaau gcaguugacc uagaaugacc aauaccaaac agaauuuuaa gaacaggugg     4440

ccaacuccua uggagcuuac ucacauauua cuauucuuuu aagaacggaa aguaaaauua     4500

uuuuugacug aagaaaaaug augacaguga aaaacaugga aauguacuca aaacaaguga     4560

cuuuuucugu aaccuuccaa agaaacugaa uuuuccaagg aauuaaauga uaacaguggc     4620

uaaggcauag uuucuaaacu uucaguaaga uccuggcauu cacagaaaaa aaugaugaau     4680

ggggucugga cauacagccu gagaucucaa aaugacaaug aaauucacaa cuuuuucuca     4740

gagacauuca uguuuccugc auaugcuaca acugcaguuu gaaagaggca gcaaugggag     4800

caacccuuua caagaaacaa auugugauau auucaugugu uggacggcag uaaauaagau     4860

gaaaccugag gagucagauc caccuucccc cauucauaga ggcuuuucag ccucauuuug     4920

agguacaguu acauaucuuu ugccuuuugc ccccgugcau agcuaucuac agccaaucac     4980

agaucacaga gucacuggac uauagagcug gaaggaagcu cagagacaau gccaaggggg     5040

cagaaaauuu aucagaagcc agucccagug cguuuccucc auuuccuucu gcaggaagac     5100

uauuuugggc ugccugaaca uuguaucaaa ccugcuaccu auacuauggu cuaccuuucc     5160

uccaguggaa uuacaaaggc acuaacugaa augccuucua gaaacagaga aaacgaaacu     5220

guacuuauuu acucuugaua cacagauuau uuauaaaaca gauugaagua accuguuaac     5280

uggcaaaaag agaaugagau cggauuuaaa uguauggcag uaaguccuau ugaucccucc     5340

aguuaucuca guaugacugc aguauauuca uucacuaaaa ccacucacua gauaccaacu     5400

acacaccugg cacugcagau guaaagguca gucacacaug uucugacuuu acagaguuca     5460

caguagcagu ggaggaugau auauguggaa acaaaaaagg cauugauucu auucagagca     5520

cuguuagggc ucaaaggaga gaggggucuu uccaccuaag aaaugaggaa uagggucauc     5580

auagaaguga ccuuaagucu uaaaaauuaa gaaggggauu ccaagcugcu ucagacagag     5640

acacaucgag cuaaaacaca gagguaugaa agagcacagg gacuuuagga auugcacagu     5700

ucauucuaac aggaacaaaa ggcucaaggg gggcaagaaa ugaggcugua uggaaagaga     5760

uucaauguaa gcacuuuaua aaauagauua auuucugauu caaugaagca uuucuugauc     5820

auuguguaca aggcacuaca ugcaucaugg aaaauucauu aggaugcauu gccagcacuu     5880

ugcagaacug auauuauuca gccucaagcu uuccaguggc caaagggaaa ugcugacugc     5940

uuuucauaua uuugagucaa agauuuuuua uauggucaau gaagacuaau auaagggcag     6000

ugggauuuuc acagaugcau gccauguugu cgagagccuc uuagauuuuc ucaacuguga     6060

gaaagaaaaa cgaaaauguu gaagacguug agucuggaga ggggauacua aucacugucc     6120

aguugggcac uggugggaau ggggaaaugg cacaggaaug caagccucuc cacccuaccc     6180

cccgaacucc agccauacac ucaucguuuc acaaaauaua aaugaguuag cauuaaaugu     6240

uucagaguaa auaauuccuu uucccgaaau gcaugaagau agaguaacag acuucucaca     6300

cuguauuuuu aggguaugga gaauuuagaa gguuaaagaa uuacugcuuc aauuuuucag     6360

uuaaaaaaaa aucaggaagc ucuguucauu caggcuaugc accaugugca cagucaagaa     6420

uuagcagaaa cccucugcau uuacaaacac uuugugcuau aaaaaaguaa uuuuuaaaaa     6480

gccacgugug ugugugugua uauauauaua uauauauaua uuuaaagcca agguuuugau     6540

acuuuuuuac aaaaacuaca agagaaaaca aauauaccug uccaaaccau auacuuuuaa     6600

aagagcauuu uuuuuuccau acaagcuguu guuaauuugg ggguaaagug cugauuugca     6660

aacuucauca aauuguuccc aaguggauuc uccuuguuug ucucccccua ccaaccccaa     6720

aguuaccaua uuugauguaa gaaucaggca uguuagaaug uugugucaca cuaacugauu     6780

cugcucuuuu ugucuuguca uucaaguucc guuagcuucu guacgcggug cccuuugcag     6840

ucuggugucu cuuccagagg cgagggggcu gaggaugggg ugcugcaucu cacuagcuau     6900

acuggcauca ucuugguaaa cugaaaacca aauguggaca uuuguaaaau cagugcacug     6960

uuucuagaga gagauuaaau ucauuuaaaa aaaa                                 6994


<210>  16
<211>  700
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Leu Pro Glu Pro Gly Pro Leu Arg Leu Leu Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Gln Leu Gln His Leu Ala Ala Ala 
            20                  25                  30          


Ala Ala Asp Pro Leu Leu Gly Gly Gln Gly Pro Ala Lys Asp Cys Glu 
        35                  40                  45              


Lys Asp Gln Phe Gln Cys Arg Asn Glu Arg Cys Ile Pro Ser Val Trp 
    50                  55                  60                  


Arg Cys Asp Glu Asp Asp Asp Cys Leu Asp His Ser Asp Glu Asp Asp 
65                  70                  75                  80  


Cys Pro Lys Lys Thr Cys Ala Asp Ser Asp Phe Thr Cys Asp Asn Gly 
                85                  90                  95      


His Cys Ile His Glu Arg Trp Lys Cys Asp Gly Glu Glu Glu Cys Pro 
            100                 105                 110         


Asp Gly Ser Asp Glu Ser Glu Ala Thr Cys Thr Lys Gln Val Cys Pro 
        115                 120                 125             


Ala Glu Lys Leu Ser Cys Gly Pro Thr Ser His Lys Cys Val Pro Ala 
    130                 135                 140                 


Ser Trp Arg Cys Asp Gly Glu Lys Asp Cys Glu Gly Gly Ala Asp Glu 
145                 150                 155                 160 


Ala Gly Cys Ala Thr Ser Leu Gly Thr Cys Arg Gly Asp Glu Phe Gln 
                165                 170                 175     


Cys Gly Asp Gly Thr Cys Val Leu Ala Ile Lys His Cys Asn Gln Glu 
            180                 185                 190         


Gln Asp Cys Pro Asp Gly Ser Asp Glu Ala Gly Cys Leu Gln Gly Leu 
        195                 200                 205             


Asn Glu Cys Leu His Asn Asn Gly Gly Cys Ser His Ile Cys Thr Asp 
    210                 215                 220                 


Leu Lys Ile Gly Phe Glu Cys Thr Cys Pro Ala Gly Phe Gln Leu Leu 
225                 230                 235                 240 


Asp Gln Lys Thr Cys Gly Asp Ile Asp Glu Cys Lys Asp Pro Asp Ala 
                245                 250                 255     


Cys Ser Gln Ile Cys Val Asn Tyr Lys Gly Tyr Phe Lys Cys Glu Cys 
            260                 265                 270         


Tyr Pro Gly Tyr Glu Met Asp Leu Leu Thr Lys Asn Cys Lys Ala Ala 
        275                 280                 285             


Ala Gly Lys Ser Pro Ser Leu Ile Phe Thr Asn Arg His Glu Val Arg 
    290                 295                 300                 


Arg Ile Asp Leu Val Lys Arg Asn Tyr Ser Arg Leu Ile Pro Met Leu 
305                 310                 315                 320 


Lys Asn Val Val Ala Leu Asp Val Glu Val Ala Thr Asn Arg Ile Tyr 
                325                 330                 335     


Trp Cys Asp Leu Ser Tyr Arg Lys Ile Tyr Ser Ala Tyr Met Asp Lys 
            340                 345                 350         


Ala Ser Asp Pro Lys Glu Gln Glu Val Leu Ile Asp Glu Gln Leu His 
        355                 360                 365             


Ser Pro Glu Gly Leu Ala Val Asp Trp Val His Lys His Ile Tyr Trp 
    370                 375                 380                 


Thr Asp Ser Gly Asn Lys Thr Ile Ser Val Ala Thr Val Asp Gly Gly 
385                 390                 395                 400 


Arg Arg Arg Thr Leu Phe Ser Arg Asn Leu Ser Glu Pro Arg Ala Ile 
                405                 410                 415     


Ala Val Asp Pro Leu Arg Gly Phe Met Tyr Trp Ser Asp Trp Gly Asp 
            420                 425                 430         


Gln Ala Lys Ile Glu Lys Ser Gly Leu Asn Gly Val Asp Arg Gln Thr 
        435                 440                 445             


Leu Val Ser Asp Asn Ile Glu Trp Pro Asn Gly Ile Thr Leu Asp Leu 
    450                 455                 460                 


Leu Ser Gln Arg Leu Tyr Trp Val Asp Ser Lys Leu His Gln Leu Ser 
465                 470                 475                 480 


Ser Ile Asp Phe Ser Gly Gly Asn Arg Lys Thr Leu Ile Ser Ser Thr 
                485                 490                 495     


Asp Phe Leu Ser His Pro Phe Gly Ile Ala Val Phe Glu Asp Lys Val 
            500                 505                 510         


Phe Trp Thr Asp Leu Glu Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu 
        515                 520                 525             


Asn Gly Leu Glu Ile Ser Ile Leu Ala Glu Asn Leu Asn Asn Pro His 
    530                 535                 540                 


Asp Ile Val Ile Phe His Glu Leu Lys Gln Pro Arg Ala Pro Asp Ala 
545                 550                 555                 560 


Cys Glu Leu Ser Val Gln Pro Asn Gly Gly Cys Glu Tyr Leu Cys Leu 
                565                 570                 575     


Pro Ala Pro Gln Ile Ser Ser His Ser Pro Lys Tyr Thr Cys Ala Cys 
            580                 585                 590         


Pro Asp Thr Met Trp Leu Gly Pro Asp Met Lys Arg Cys Tyr Arg Asp 
        595                 600                 605             


Ala Asn Glu Asp Ser Lys Met Gly Ser Thr Val Thr Ala Ala Val Ile 
    610                 615                 620                 


Gly Ile Ile Val Pro Ile Val Val Ile Ala Leu Leu Cys Met Ser Gly 
625                 630                 635                 640 


Tyr Leu Ile Trp Arg Asn Trp Lys Arg Lys Asn Thr Lys Ser Met Asn 
                645                 650                 655     


Phe Asp Asn Pro Val Tyr Arg Lys Thr Thr Glu Glu Glu Asp Glu Asp 
            660                 665                 670         


Glu Leu His Ile Gly Arg Thr Ala Gln Ile Gly His Val Tyr Pro Ala 
        675                 680                 685             


Arg Val Ala Leu Ser Leu Glu Asp Asp Gly Leu Pro 
    690                 695                 700 


<210>  17
<211>  7606
<212>  RNA
<213>  Homo sapiens

<400>  17
gcuggcggcg gccgcccagg gccggggccg cgcgcccagc cugagcccgc cccgccgccg       60

agcgucaccg aaccugcuug aaaugcagcc gaggagccgg ggcgggcggc agcggcggcg      120

gcggcggcgg cgggggcagc ggcaaccccg gcgccgcggc aaggacucgg agggcugaga      180

cgcggcggcg gcggcgcggg gagcgcgggg cgcggcggcc ggagccccgg gcccgccaug      240

ggccuccccg agccgggccc ucuccggcuu cuggcgcugc ugcugcugcu gcugcugcug      300

cugcugcugc agcuccagca ucuugcggcg gcagcggcug auccgcugcu cggcggccaa      360

gggccggcca aggauugcga aaaggaccaa uuccagugcc ggaacgagcg cugcaucccc      420

ucugugugga gaugcgacga ggacgaugac ugcuuagacc acagcgacga ggacgacugc      480

cccaagaaga ccugugcaga cagugacuuc accugugaca acggccacug cauccacgaa      540

cgguggaagu gugacggcga ggaggagugu ccugauggcu ccgaugaguc cgaggccacu      600

ugcaccaagc aggugugucc ugcagagaag cugagcugug gacccaccag ccacaagugu      660

guaccugccu cguggcgcug cgacggggag aaggacugcg aggguggagc ggaugaggcc      720

ggcugugcua ccuugugcgc cccgcacgag uuccagugcg gcaaccgcuc gugccuggcc      780

gccguguucg ugugcgacgg cgacgacgac uguggugacg gcagcgauga gcgcggcugu      840

gcagacccgg ccugcgggcc ccgcgaguuc cgcugcggcg gcgauggcgg cggcgccugc      900

aucccggagc gcugggucug cgaccgccag uuugacugcg aggaccgcuc ggacgaggca      960

gccgagcucu gcggccgucc gggccccggg gccacguccg cgcccgccgc cugcgccacc     1020

gccucccagu ucgccugccg cagcggcgag ugcgugcacc ugggcuggcg cugcgacggc     1080

gaccgcgacu gcaaagacaa aucggacgag gccgacugcc cacugggcac cugccguggg     1140

gacgaguucc agugugggga ugggacaugu guccuugcaa ucaagcacug caaccaggag     1200

caggacuguc cagaugggag ugaugaagcu ggcugccuac aggggcugaa cgagugucug     1260

cacaacaaug gcggcugcuc acacaucugc acugaccuca agauuggcuu ugaaugcacg     1320

ugcccagcag gcuuccagcu ccuggaccag aagaccugug gcgacauuga ugagugcaag     1380

gacccagaug ccugcagcca gaucuguguc aauuacaagg gcuauuuuaa gugugagugc     1440

uacccuggcu acgagaugga ccuacugacc aagaacugca aggcugcugc uggcaagagc     1500

ccaucccuaa ucuucaccaa ccggcacgag gugcggagga ucgaccuggu gaagcggaac     1560

uauucacgcc ucauccccau gcucaagaau gucguggcac uagaugugga aguugccacc     1620

aaucgcaucu acugguguga ccucuccuac cguaagaucu auagcgccua cauggacaag     1680

gccagugacc cgaaagagca ggagguccuc auugacgagc aguugcacuc uccagagggc     1740

cuggcagugg acugggucca caagcacauc uacuggacug acucgggcaa uaagaccauc     1800

ucaguggcca caguugaugg uggccgccga cgcacucucu ucagccguaa ccucagugaa     1860

ccccgggcca ucgcuguuga cccccugcga ggguucaugu auuggucuga cuggggggac     1920

caggccaaga uugagaaauc ugggcucaac gguguggacc ggcaaacacu ggugucagac     1980

aauauugaau ggcccaacgg aaucacccug gaucugcuga gccagcgcuu guacugggua     2040

gacuccaagc uacaccaacu guccagcauu gacuucagug gaggcaacag aaagacgcug     2100

aucuccucca cugacuuccu gagccacccu uuugggauag cuguguuuga ggacaaggug     2160

uucuggacag accuggagaa cgaggccauu uucagugcaa aucggcucaa uggccuggaa     2220

aucuccaucc uggcugagaa ccucaacaac ccacaugaca uugucaucuu ccaugagcug     2280

aagcagccaa gagcuccaga ugccugugag cugagugucc agccuaaugg aggcugugaa     2340

uaccugugcc uuccugcucc ucagaucucc agccacucuc ccaaguacac augugccugu     2400

ccugacacaa uguggcuggg uccagacaug aagaggugcu accgagcacc ucaaucuacc     2460

ucaacuacga cguuagcuuc uaccaugacg aggacaguac cugccaccac aagagccccc     2520

gggaccaccg uccacagauc caccuaccag aaccacagca cagagacacc aagccugaca     2580

gcugcagucc caagcucagu uagugucccc agggcuccca gcaucagccc gucuacccua     2640

agcccugcaa ccagcaacca cucccagcac uaugcaaaug aagacaguaa gaugggcuca     2700

acagucacug ccgcuguuau cgggaucauc gugcccauag uggugauagc ccuccugugc     2760

augaguggau accugaucug gagaaacugg aagcggaaga acaccaaaag caugaauuuu     2820

gacaacccag ucuacaggaa aacaacagaa gaagaagacg aagaugagcu ccauauaggg     2880

agaacugcuc agauuggcca ugucuauccu gcacgagugg cauuaagccu ugaagaugau     2940

ggacuacccu gaggauggga ucacccccuu cgugccucau ggaauucagu cccaugcacu     3000

acacucugga ugguguauga cuggaugaau ggguuucuau auaugggucu gugugagugu     3060

augugugugu gugauuuuuu uuuuaaauuu auguugcgga aagguaacca caaaguuaug     3120

augaacugca aacauccaaa ggaugugaga guuuuucuau guauaauguu uuauacacuu     3180

uuuaacuggu ugcacuaccc augaggaauu cguggaaugg cuacugcuga cuaacaugau     3240

gcacauaacc aaaugggggc caauggcaca guaccuuacu caucauuuaa aaacuauauu     3300

uacagaagau guuugguugc ugggggggcu uuuuuagguu uuggggcauu uguuuuuugu     3360

aaauaagaug auuaugcuuu guggcuaucc aucaacauaa guaaaaaaaa aaaaaaaaca     3420

cuucaacucc cucccccauu uagauuauuu auuaacauau uuuaaaaauc agaugaguuc     3480

uauaaauaau uuagagaagu gagaguauuu auuuuuggca uguuuggccc accacacaga     3540

cucugugugu guaugugugu guuuauaugu guaugugugu gacagaaaaa ucuguagaga     3600

agaggcacau cuauggcuac uguucaaaua cauaaagaua aauuuauuuu cacacagucc     3660

acaaggggua uaucuuguag uuuucagaaa agccuuugga aaucuggauc agaaaauaga     3720

uaccaugguu ugugcaauua uguaguaaaa aaggcaaauc uuuucaccuc uggcuauucc     3780

ugagacccca ggaagucagg aaaagccuuu cagcucaccc auggcugcug ugacuccuac     3840

cagggcuuuc uuggcuuugg cgaaggucag uguacagaca uuccauggua ccagagugcu     3900

cagaaacuca agauaggaua ugccucaccc ucagcuacuc cuuguuuuaa aguucagcuc     3960

uuugaguaac uucuucaauu ucuuucagga cacuuggguu gaauucagua aguuuccucu     4020

gaagcacccu gaagggugcc auccuuacag agcuaagugg agacguuucc agaucagccc     4080

aaguuuacua uagagacugg cccaggcacu gaaugucuag gacaugcugu ggaugaagau     4140

aaagauggug gaauagguuu uaucacaucu cuuauuucuc uuuuccccuu acucucuacc     4200

auuuccuuua uguggggaaa cauuuuaagg uaauaaauag guuacuuacc aucauauguu     4260

cauauagaug aaacuaauuu uuggcuuaag ucagaacaac uggccaaaau ugaagucaua     4320

uuugaggggg gaaauggcau acgcaauauu auauuauauu ggauauuuau guucacacag     4380

gaauuugguu uacugcuuug uaaauaaaag gaaaaacucc ggguauaugu auagauguuc     4440

uucauuauag acaucuucuu ugcuuuucuu ggccuugggg gaggaaggga gaagugcucu     4500

uuucuacuug uggggucucc cauuggaaac auaauccuau agucccagaa ggauucaguc     4560

cccaguggcu uucccaucca aagagaaaga guuugaguuu cuuaacucug cuguucugcc     4620

acuuacuccc acuagacaac cagggacaag gugcaacaug gaaguguuug acuuaaguag     4680

gagcagagga gcugcaucua aucucaucau accuggaacu ugacacacuu aagcaaaugc     4740

cuucccaucc cuaccugcca gaugccccca acucaaugaa guuggauguc ucaccagcuu     4800

gauacccuuu gaauuuucag ucagacauuc uggaguucua gcauccugua ccuaggaccu     4860

uccucugugu cacucuuggc cuccuaaacu cuaagaaaau aacuauauuc uggagcuugg     4920

gcaguguguu uugcauaauc cagcaaucuc cucaugacau gcauguguug auaguccuga     4980

aacauucauu gagaggguaa augcaguuga ccuagaauga ccaauaccaa acagaauuuu     5040

aagaacaggu ggccaacucc uauggagcuu acucacauau uacuauucuu uuaagaacgg     5100

aaaguaaaau uauuuuugac ugaagaaaaa ugaugacagu gaaaaacaug gaaauguacu     5160

caaaacaagu gacuuuuucu guaaccuucc aaagaaacug aauuuuccaa ggaauuaaau     5220

gauaacagug gcuaaggcau aguuucuaaa cuuucaguaa gauccuggca uucacagaaa     5280

aaaaugauga auggggucug gacauacagc cugagaucuc aaaaugacaa ugaaauucac     5340

aacuuuuucu cagagacauu cauguuuccu gcauaugcua caacugcagu uugaaagagg     5400

cagcaauggg agcaacccuu uacaagaaac aaauugugau auauucaugu guuggacggc     5460

aguaaauaag augaaaccug aggagucaga uccaccuucc cccauucaua gaggcuuuuc     5520

agccucauuu ugagguacag uuacauaucu uuugccuuuu gcccccgugc auagcuaucu     5580

acagccaauc acagaucaca gagucacugg acuauagagc uggaaggaag cucagagaca     5640

augccaaggg ggcagaaaau uuaucagaag ccagucccag ugcguuuccu ccauuuccuu     5700

cugcaggaag acuauuuugg gcugccugaa cauuguauca aaccugcuac cuauacuaug     5760

gucuaccuuu ccuccagugg aauuacaaag gcacuaacug aaaugccuuc uagaaacaga     5820

gaaaacgaaa cuguacuuau uuacucuuga uacacagauu auuuauaaaa cagauugaag     5880

uaaccuguua acuggcaaaa agagaaugag aucggauuua aauguauggc aguaaguccu     5940

auugaucccu ccaguuaucu caguaugacu gcaguauauu cauucacuaa aaccacucac     6000

uagauaccaa cuacacaccu ggcacugcag auguaaaggu cagucacaca uguucugacu     6060

uuacagaguu cacaguagca guggaggaug auauaugugg aaacaaaaaa ggcauugauu     6120

cuauucagag cacuguuagg gcucaaagga gagagggguc uuuccaccua agaaaugagg     6180

aauaggguca ucauagaagu gaccuuaagu cuuaaaaauu aagaagggga uuccaagcug     6240

cuucagacag agacacaucg agcuaaaaca cagagguaug aaagagcaca gggacuuuag     6300

gaauugcaca guucauucua acaggaacaa aaggcucaag gggggcaaga aaugaggcug     6360

uauggaaaga gauucaaugu aagcacuuua uaaaauagau uaauuucuga uucaaugaag     6420

cauuucuuga ucauugugua caaggcacua caugcaucau ggaaaauuca uuaggaugca     6480

uugccagcac uuugcagaac ugauauuauu cagccucaag cuuuccagug gccaaaggga     6540

aaugcugacu gcuuuucaua uauuugaguc aaagauuuuu uauaugguca augaagacua     6600

auauaagggc agugggauuu ucacagaugc augccauguu gucgagagcc ucuuagauuu     6660

ucucaacugu gagaaagaaa aacgaaaaug uugaagacgu ugagucugga gaggggauac     6720

uaaucacugu ccaguugggc acugguggga auggggaaau ggcacaggaa ugcaagccuc     6780

uccacccuac cccccgaacu ccagccauac acucaucguu ucacaaaaua uaaaugaguu     6840

agcauuaaau guuucagagu aaauaauucc uuuucccgaa augcaugaag auagaguaac     6900

agacuucuca cacuguauuu uuaggguaug gagaauuuag aagguuaaag aauuacugcu     6960

ucaauuuuuc aguuaaaaaa aaaucaggaa gcucuguuca uucaggcuau gcaccaugug     7020

cacagucaag aauuagcaga aacccucugc auuuacaaac acuuugugcu auaaaaaagu     7080

aauuuuuaaa aagccacgug ugugugugug uauauauaua uauauauaua uauuuaaagc     7140

caagguuuug auacuuuuuu acaaaaacua caagagaaaa caaauauacc uguccaaacc     7200

auauacuuuu aaaagagcau uuuuuuuucc auacaagcug uuguuaauuu ggggguaaag     7260

ugcugauuug caaacuucau caaauuguuc ccaaguggau ucuccuuguu ugucuccccc     7320

uaccaacccc aaaguuacca uauuugaugu aagaaucagg cauguuagaa uguuguguca     7380

cacuaacuga uucugcucuu uuugucuugu cauucaaguu ccguuagcuu cuguacgcgg     7440

ugcccuuugc agucuggugu cucuuccaga ggcgaggggg cugaggaugg ggugcugcau     7500

cucacuagcu auacuggcau caucuuggua aacugaaaac caaaugugga cauuuguaaa     7560

aucagugcac uguuucuaga gagagauuaa auucauuuaa aaaaaa                    7606


<210>  18
<211>  904
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly Leu Pro Glu Pro Gly Pro Leu Arg Leu Leu Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Gln Leu Gln His Leu Ala Ala Ala 
            20                  25                  30          


Ala Ala Asp Pro Leu Leu Gly Gly Gln Gly Pro Ala Lys Asp Cys Glu 
        35                  40                  45              


Lys Asp Gln Phe Gln Cys Arg Asn Glu Arg Cys Ile Pro Ser Val Trp 
    50                  55                  60                  


Arg Cys Asp Glu Asp Asp Asp Cys Leu Asp His Ser Asp Glu Asp Asp 
65                  70                  75                  80  


Cys Pro Lys Lys Thr Cys Ala Asp Ser Asp Phe Thr Cys Asp Asn Gly 
                85                  90                  95      


His Cys Ile His Glu Arg Trp Lys Cys Asp Gly Glu Glu Glu Cys Pro 
            100                 105                 110         


Asp Gly Ser Asp Glu Ser Glu Ala Thr Cys Thr Lys Gln Val Cys Pro 
        115                 120                 125             


Ala Glu Lys Leu Ser Cys Gly Pro Thr Ser His Lys Cys Val Pro Ala 
    130                 135                 140                 


Ser Trp Arg Cys Asp Gly Glu Lys Asp Cys Glu Gly Gly Ala Asp Glu 
145                 150                 155                 160 


Ala Gly Cys Ala Thr Leu Cys Ala Pro His Glu Phe Gln Cys Gly Asn 
                165                 170                 175     


Arg Ser Cys Leu Ala Ala Val Phe Val Cys Asp Gly Asp Asp Asp Cys 
            180                 185                 190         


Gly Asp Gly Ser Asp Glu Arg Gly Cys Ala Asp Pro Ala Cys Gly Pro 
        195                 200                 205             


Arg Glu Phe Arg Cys Gly Gly Asp Gly Gly Gly Ala Cys Ile Pro Glu 
    210                 215                 220                 


Arg Trp Val Cys Asp Arg Gln Phe Asp Cys Glu Asp Arg Ser Asp Glu 
225                 230                 235                 240 


Ala Ala Glu Leu Cys Gly Arg Pro Gly Pro Gly Ala Thr Ser Ala Pro 
                245                 250                 255     


Ala Ala Cys Ala Thr Ala Ser Gln Phe Ala Cys Arg Ser Gly Glu Cys 
            260                 265                 270         


Val His Leu Gly Trp Arg Cys Asp Gly Asp Arg Asp Cys Lys Asp Lys 
        275                 280                 285             


Ser Asp Glu Ala Asp Cys Pro Leu Gly Thr Cys Arg Gly Asp Glu Phe 
    290                 295                 300                 


Gln Cys Gly Asp Gly Thr Cys Val Leu Ala Ile Lys His Cys Asn Gln 
305                 310                 315                 320 


Glu Gln Asp Cys Pro Asp Gly Ser Asp Glu Ala Gly Cys Leu Gln Gly 
                325                 330                 335     


Leu Asn Glu Cys Leu His Asn Asn Gly Gly Cys Ser His Ile Cys Thr 
            340                 345                 350         


Asp Leu Lys Ile Gly Phe Glu Cys Thr Cys Pro Ala Gly Phe Gln Leu 
        355                 360                 365             


Leu Asp Gln Lys Thr Cys Gly Asp Ile Asp Glu Cys Lys Asp Pro Asp 
    370                 375                 380                 


Ala Cys Ser Gln Ile Cys Val Asn Tyr Lys Gly Tyr Phe Lys Cys Glu 
385                 390                 395                 400 


Cys Tyr Pro Gly Tyr Glu Met Asp Leu Leu Thr Lys Asn Cys Lys Ala 
                405                 410                 415     


Ala Ala Gly Lys Ser Pro Ser Leu Ile Phe Thr Asn Arg His Glu Val 
            420                 425                 430         


Arg Arg Ile Asp Leu Val Lys Arg Asn Tyr Ser Arg Leu Ile Pro Met 
        435                 440                 445             


Leu Lys Asn Val Val Ala Leu Asp Val Glu Val Ala Thr Asn Arg Ile 
    450                 455                 460                 


Tyr Trp Cys Asp Leu Ser Tyr Arg Lys Ile Tyr Ser Ala Tyr Met Asp 
465                 470                 475                 480 


Lys Ala Ser Asp Pro Lys Glu Gln Glu Val Leu Ile Asp Glu Gln Leu 
                485                 490                 495     


His Ser Pro Glu Gly Leu Ala Val Asp Trp Val His Lys His Ile Tyr 
            500                 505                 510         


Trp Thr Asp Ser Gly Asn Lys Thr Ile Ser Val Ala Thr Val Asp Gly 
        515                 520                 525             


Gly Arg Arg Arg Thr Leu Phe Ser Arg Asn Leu Ser Glu Pro Arg Ala 
    530                 535                 540                 


Ile Ala Val Asp Pro Leu Arg Gly Phe Met Tyr Trp Ser Asp Trp Gly 
545                 550                 555                 560 


Asp Gln Ala Lys Ile Glu Lys Ser Gly Leu Asn Gly Val Asp Arg Gln 
                565                 570                 575     


Thr Leu Val Ser Asp Asn Ile Glu Trp Pro Asn Gly Ile Thr Leu Asp 
            580                 585                 590         


Leu Leu Ser Gln Arg Leu Tyr Trp Val Asp Ser Lys Leu His Gln Leu 
        595                 600                 605             


Ser Ser Ile Asp Phe Ser Gly Gly Asn Arg Lys Thr Leu Ile Ser Ser 
    610                 615                 620                 


Thr Asp Phe Leu Ser His Pro Phe Gly Ile Ala Val Phe Glu Asp Lys 
625                 630                 635                 640 


Val Phe Trp Thr Asp Leu Glu Asn Glu Ala Ile Phe Ser Ala Asn Arg 
                645                 650                 655     


Leu Asn Gly Leu Glu Ile Ser Ile Leu Ala Glu Asn Leu Asn Asn Pro 
            660                 665                 670         


His Asp Ile Val Ile Phe His Glu Leu Lys Gln Pro Arg Ala Pro Asp 
        675                 680                 685             


Ala Cys Glu Leu Ser Val Gln Pro Asn Gly Gly Cys Glu Tyr Leu Cys 
    690                 695                 700                 


Leu Pro Ala Pro Gln Ile Ser Ser His Ser Pro Lys Tyr Thr Cys Ala 
705                 710                 715                 720 


Cys Pro Asp Thr Met Trp Leu Gly Pro Asp Met Lys Arg Cys Tyr Arg 
                725                 730                 735     


Ala Pro Gln Ser Thr Ser Thr Thr Thr Leu Ala Ser Thr Met Thr Arg 
            740                 745                 750         


Thr Val Pro Ala Thr Thr Arg Ala Pro Gly Thr Thr Val His Arg Ser 
        755                 760                 765             


Thr Tyr Gln Asn His Ser Thr Glu Thr Pro Ser Leu Thr Ala Ala Val 
    770                 775                 780                 


Pro Ser Ser Val Ser Val Pro Arg Ala Pro Ser Ile Ser Pro Ser Thr 
785                 790                 795                 800 


Leu Ser Pro Ala Thr Ser Asn His Ser Gln His Tyr Ala Asn Glu Asp 
                805                 810                 815     


Ser Lys Met Gly Ser Thr Val Thr Ala Ala Val Ile Gly Ile Ile Val 
            820                 825                 830         


Pro Ile Val Val Ile Ala Leu Leu Cys Met Ser Gly Tyr Leu Ile Trp 
        835                 840                 845             


Arg Asn Trp Lys Arg Lys Asn Thr Lys Ser Met Asn Phe Asp Asn Pro 
    850                 855                 860                 


Val Tyr Arg Lys Thr Thr Glu Glu Glu Asp Glu Asp Glu Leu His Ile 
865                 870                 875                 880 


Gly Arg Thr Ala Gln Ile Gly His Val Tyr Pro Ala Arg Val Ala Leu 
                885                 890                 895     


Ser Leu Glu Asp Asp Gly Leu Pro 
            900                 


<210>  19
<211>  2358
<212>  RNA
<213>  Homo sapiens

<400>  19
aaacucacac aacaacucuu ccccgcugag aggagacagc cagugcgacu ccacccucca       60

gcucgacggc agccgccccg gccgacagcc ccgagacgac agcccggcgc gucccggucc      120

ccaccuccga ccaccgccag cgcuccaggc cccgccgcuc cccgcucgcc gccaccgcgc      180

ccuccgcucc gcccgcagug ccaaccauga ccgccgccag uaugggcccc guccgcgucg      240

ccuucguggu ccuccucgcc cucugcagcc ggccggccgu cggccagaac ugcagcgggc      300

cgugccggug cccggacgag ccggcgccgc gcugcccggc gggcgugagc cucgugcugg      360

acggcugcgg cugcugccgc gucugcgcca agcagcuggg cgagcugugc accgagcgcg      420

accccugcga cccgcacaag ggccucuucu gugacuucgg cuccccggcc aaccgcaaga      480

ucggcgugug caccgccaaa gauggugcuc ccugcaucuu cggugguacg guguaccgca      540

gcggagaguc cuuccagagc agcugcaagu accagugcac gugccuggac ggggcggugg      600

gcugcaugcc ccugugcagc auggacguuc gucugcccag cccugacugc cccuucccga      660

ggagggucaa gcugcccggg aaaugcugcg aggagugggu gugugacgag cccaaggacc      720

aaaccguggu ugggccugcc cucgcggcuu accgacugga agacacguuu ggcccagacc      780

caacuaugau uagagccaac ugccuggucc agaccacaga guggagcgcc uguuccaaga      840

ccugugggau gggcaucucc acccggguua ccaaugacaa cgccuccugc aggcuagaga      900

agcagagccg ccugugcaug gucaggccuu gcgaagcuga ccuggaagag aacauuaaga      960

agggcaaaaa gugcauccgu acucccaaaa ucuccaagcc uaucaaguuu gagcuuucug     1020

gcugcaccag caugaagaca uaccgagcua aauucugugg aguauguacc gacggccgau     1080

gcugcacccc ccacagaacc accacccugc cgguggaguu caagugcccu gacggcgagg     1140

ucaugaagaa gaacaugaug uucaucaaga ccugugccug ccauuacaac ugucccggag     1200

acaaugacau cuuugaaucg cuguacuaca ggaagaugua cggagacaug gcaugaagcc     1260

agagagugag agacauuaac ucauuagacu ggaacuugaa cugauucaca ucucauuuuu     1320

ccguaaaaau gauuucagua gcacaaguua uuuaaaucug uuuuucuaac ugggggaaaa     1380

gauucccacc caauucaaaa cauugugcca ugucaaacaa auagucuauc aaccccagac     1440

acugguuuga agaauguuaa gacuugacag uggaacuaca uuaguacaca gcaccagaau     1500

guauauuaag guguggcuuu aggagcagug ggaggguacc agcagaaagg uuaguaucau     1560

cagauagcau cuuauacgag uaauaugccu gcuauuugaa guguaauuga gaaggaaaau     1620

uuuagcgugc ucacugaccu gccuguagcc ccagugacag cuaggaugug cauucuccag     1680

ccaucaagag acugagucaa guuguuccuu aagucagaac agcagacuca gcucugacau     1740

ucugauucga augacacugu ucaggaaucg gaauccuguc gauuagacug gacagcuugu     1800

ggcaagugaa uuugccugua acaagccaga uuuuuuaaaa uuuauauugu aaauauugug     1860

ugugugugug uguguguaua uauauauaua uguacaguua ucuaaguuaa uuuaaaguug     1920

uuugugccuu uuuauuuuug uuuuuaaugc uuugauauuu caauguuagc cucaauuucu     1980

gaacaccaua gguagaaugu aaagcuuguc ugaucguuca aagcaugaaa uggauacuua     2040

uauggaaauu cugcucagau agaaugacag uccgucaaaa cagauuguuu gcaaagggga     2100

ggcaucagug uccuuggcag gcugauuucu agguaggaaa ugugguagcc ucacuuuuaa     2160

ugaacaaaug gccuuuauua aaaacugagu gacucuauau agcugaucag uuuuuucacc     2220

uggaagcauu uguuucuacu uugauaugac uguuuuucgg acaguuuauu uguugagagu     2280

gugaccaaaa guuacauguu ugcaccuuuc uaguugaaaa uaaaguguau auuuuuucua     2340

uaaaaaaaaa aaaaaaaa                                                   2358


<210>  20
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Thr Ala Ala Ser Met Gly Pro Val Arg Val Ala Phe Val Val Leu 
1               5                   10                  15      


Leu Ala Leu Cys Ser Arg Pro Ala Val Gly Gln Asn Cys Ser Gly Pro 
            20                  25                  30          


Cys Arg Cys Pro Asp Glu Pro Ala Pro Arg Cys Pro Ala Gly Val Ser 
        35                  40                  45              


Leu Val Leu Asp Gly Cys Gly Cys Cys Arg Val Cys Ala Lys Gln Leu 
    50                  55                  60                  


Gly Glu Leu Cys Thr Glu Arg Asp Pro Cys Asp Pro His Lys Gly Leu 
65                  70                  75                  80  


Phe Cys Asp Phe Gly Ser Pro Ala Asn Arg Lys Ile Gly Val Cys Thr 
                85                  90                  95      


Ala Lys Asp Gly Ala Pro Cys Ile Phe Gly Gly Thr Val Tyr Arg Ser 
            100                 105                 110         


Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr Gln Cys Thr Cys Leu Asp 
        115                 120                 125             


Gly Ala Val Gly Cys Met Pro Leu Cys Ser Met Asp Val Arg Leu Pro 
    130                 135                 140                 


Ser Pro Asp Cys Pro Phe Pro Arg Arg Val Lys Leu Pro Gly Lys Cys 
145                 150                 155                 160 


Cys Glu Glu Trp Val Cys Asp Glu Pro Lys Asp Gln Thr Val Val Gly 
                165                 170                 175     


Pro Ala Leu Ala Ala Tyr Arg Leu Glu Asp Thr Phe Gly Pro Asp Pro 
            180                 185                 190         


Thr Met Ile Arg Ala Asn Cys Leu Val Gln Thr Thr Glu Trp Ser Ala 
        195                 200                 205             


Cys Ser Lys Thr Cys Gly Met Gly Ile Ser Thr Arg Val Thr Asn Asp 
    210                 215                 220                 


Asn Ala Ser Cys Arg Leu Glu Lys Gln Ser Arg Leu Cys Met Val Arg 
225                 230                 235                 240 


Pro Cys Glu Ala Asp Leu Glu Glu Asn Ile Lys Lys Gly Lys Lys Cys 
                245                 250                 255     


Ile Arg Thr Pro Lys Ile Ser Lys Pro Ile Lys Phe Glu Leu Ser Gly 
            260                 265                 270         


Cys Thr Ser Met Lys Thr Tyr Arg Ala Lys Phe Cys Gly Val Cys Thr 
        275                 280                 285             


Asp Gly Arg Cys Cys Thr Pro His Arg Thr Thr Thr Leu Pro Val Glu 
    290                 295                 300                 


Phe Lys Cys Pro Asp Gly Glu Val Met Lys Lys Asn Met Met Phe Ile 
305                 310                 315                 320 


Lys Thr Cys Ala Cys His Tyr Asn Cys Pro Gly Asp Asn Asp Ile Phe 
                325                 330                 335     


Glu Ser Leu Tyr Tyr Arg Lys Met Tyr Gly Asp Met Ala 
            340                 345                 


<210>  21
<211>  1939
<212>  RNA
<213>  Homo sapiens

<400>  21
aggaaggagg gguggccuga ccccucggca gucccucccc ucagccuuuc cccaaauugc       60

uacuucucug gggcuccagg uccugcuugu gcucagcucc agcucacugg cuggccaccg      120

agacuucugg acaggaaacu gcaccauccu cuucucccag caagggggcu ccagagacug      180

cccacccagg aagucuggug gccuggggau uuggacagug ccuugguaau gaccagggcu      240

ccaggaagag auguccuugu ggcugggggc cccugugccu gacauuccuc cugacucugc      300

gguggagcug uggaagccag gcgcacagga ugcaagcagc caggcccagg gaggcagcag      360

cugcauccuc agagaggaag ccaggaugcc ccacucugcu ggggguacug cagggguggg      420

gcuggaggcu gcagagccca cagcccugcu caccagggca gagcccccuu cagaacccac      480

agagauccgu ccacaaaagc ggaaaaaggg gccagccccc aaaaugcugg ggaacgagcu      540

augcagcgug uguggggaca aggccucggg cuuccacuac aauguucuga gcugcgaggg      600

cugcaaggga uucuuccgcc gcagcgucau caagggagcg cacuacaucu gccacagugg      660

cggccacugc cccauggaca ccuacaugcg ucgcaagugc caggaguguc ggcuucgcaa      720

augccgucag gcuggcaugc gggaggagug uguccuguca gaagaacaga uccgccugaa      780

gaaacugaag cggcaagagg aggaacaggc ucaugccaca uccuugcccc ccagggcuuc      840

cucacccccc caaauccugc cccagcucag cccggaacaa cugggcauga ucgagaagcu      900

cgucgcugcc cagcaacagu guaaccggcg cuccuuuucu gaccggcuuc gagucacgcc      960

uuggcccaug gcaccagauc cccauagccg ggaggcccgu cagcagcgcu uugcccacuu     1020

cacugagcug gccaucgucu cugugcagga gauaguugac uuugcuaaac agcuacccgg     1080

cuuccugcag cucagccggg aggaccagau ugcccugcug aagaccucug cgaucgaggu     1140

gaugcuucug gagacaucuc ggagguacaa cccugggagu gagaguauca ccuuccucaa     1200

ggauuucagu uauaaccggg aagacuuugc caaagcaggg cugcaagugg aauucaucaa     1260

ccccaucuuc gaguucucca gggccaugaa ugagcugcaa cucaaugaug ccgaguuugc     1320

cuugcucauu gcuaucagca ucuucucugc agaccggccc aacgugcagg accagcucca     1380

gguagagagg cugcagcaca cauaugugga agcccugcau gccuacgucu ccauccacca     1440

uccccaugac cgacugaugu ucccacggau gcuaaugaaa cuggugagcc uccggacccu     1500

gagcagcguc cacucagagc aaguguuugc acugcgucug caggacaaaa agcucccacc     1560

gcugcucucu gagaucuggg augugcacga augacuguuc uguccccaua uuuucuguuu     1620

ucuuggccgg auggcugagg ccugguggcu gccuccuaga aguggaacag acugagaagg     1680

gcaaacauuc cugggagcug ggcaaggaga uccucccgug gcauuaaaag agagucaaag     1740

gguugcgagu uuuguggcua cugagcagug gagcccucgc uaacacugug cugugucuga     1800

agaucaugcu gaccccacaa acggaugggc cugggggcca cuuugcacag gguucuccag     1860

agcccugccc auccugccuc caccacuucc uguuuuuccc acagggcccc aagaaaaauu     1920

cuccacuguc aaaaaaaaa                                                  1939


<210>  22
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ser Leu Trp Leu Gly Ala Pro Val Pro Asp Ile Pro Pro Asp Ser 
1               5                   10                  15      


Ala Val Glu Leu Trp Lys Pro Gly Ala Gln Asp Ala Ser Ser Gln Ala 
            20                  25                  30          


Gln Gly Gly Ser Ser Cys Ile Leu Arg Glu Glu Ala Arg Met Pro His 
        35                  40                  45              


Ser Ala Gly Gly Thr Ala Gly Val Gly Leu Glu Ala Ala Glu Pro Thr 
    50                  55                  60                  


Ala Leu Leu Thr Arg Ala Glu Pro Pro Ser Glu Pro Thr Glu Ile Arg 
65                  70                  75                  80  


Pro Gln Lys Arg Lys Lys Gly Pro Ala Pro Lys Met Leu Gly Asn Glu 
                85                  90                  95      


Leu Cys Ser Val Cys Gly Asp Lys Ala Ser Gly Phe His Tyr Asn Val 
            100                 105                 110         


Leu Ser Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Val Ile Lys 
        115                 120                 125             


Gly Ala His Tyr Ile Cys His Ser Gly Gly His Cys Pro Met Asp Thr 
    130                 135                 140                 


Tyr Met Arg Arg Lys Cys Gln Glu Cys Arg Leu Arg Lys Cys Arg Gln 
145                 150                 155                 160 


Ala Gly Met Arg Glu Glu Cys Val Leu Ser Glu Glu Gln Ile Arg Leu 
                165                 170                 175     


Lys Lys Leu Lys Arg Gln Glu Glu Glu Gln Ala His Ala Thr Ser Leu 
            180                 185                 190         


Pro Pro Arg Ala Ser Ser Pro Pro Gln Ile Leu Pro Gln Leu Ser Pro 
        195                 200                 205             


Glu Gln Leu Gly Met Ile Glu Lys Leu Val Ala Ala Gln Gln Gln Cys 
    210                 215                 220                 


Asn Arg Arg Ser Phe Ser Asp Arg Leu Arg Val Thr Pro Trp Pro Met 
225                 230                 235                 240 


Ala Pro Asp Pro His Ser Arg Glu Ala Arg Gln Gln Arg Phe Ala His 
                245                 250                 255     


Phe Thr Glu Leu Ala Ile Val Ser Val Gln Glu Ile Val Asp Phe Ala 
            260                 265                 270         


Lys Gln Leu Pro Gly Phe Leu Gln Leu Ser Arg Glu Asp Gln Ile Ala 
        275                 280                 285             


Leu Leu Lys Thr Ser Ala Ile Glu Val Met Leu Leu Glu Thr Ser Arg 
    290                 295                 300                 


Arg Tyr Asn Pro Gly Ser Glu Ser Ile Thr Phe Leu Lys Asp Phe Ser 
305                 310                 315                 320 


Tyr Asn Arg Glu Asp Phe Ala Lys Ala Gly Leu Gln Val Glu Phe Ile 
                325                 330                 335     


Asn Pro Ile Phe Glu Phe Ser Arg Ala Met Asn Glu Leu Gln Leu Asn 
            340                 345                 350         


Asp Ala Glu Phe Ala Leu Leu Ile Ala Ile Ser Ile Phe Ser Ala Asp 
        355                 360                 365             


Arg Pro Asn Val Gln Asp Gln Leu Gln Val Glu Arg Leu Gln His Thr 
    370                 375                 380                 


Tyr Val Glu Ala Leu His Ala Tyr Val Ser Ile His His Pro His Asp 
385                 390                 395                 400 


Arg Leu Met Phe Pro Arg Met Leu Met Lys Leu Val Ser Leu Arg Thr 
                405                 410                 415     


Leu Ser Ser Val His Ser Glu Gln Val Phe Ala Leu Arg Leu Gln Asp 
            420                 425                 430         


Lys Lys Leu Pro Pro Leu Leu Ser Glu Ile Trp Asp Val His Glu 
        435                 440                 445         


<210>  23
<211>  1759
<212>  RNA
<213>  Homo sapiens

<400>  23
aggaaggagg gguggccuga ccccucggca gucccucccc ucagccuuuc cccaaauugc       60

uacuucucug gggcuccagg uccugcuugu gcucagcucc agcucacugg cuggccaccg      120

agacuucugg acaggaaacu gcaccauccu cuucucccag caagggggcu ccagagacug      180

cccacccagg aagucuggug gccuggggau uuggacagug ccuugguaau gaccagggcu      240

ccaggaagag auguccuugu ggcugggggc cccugugccu gacauuccuc cugacucugc      300

gguggagcug uggaagccag gcgcacagga ugcaagcagc caggcccagg gaggcagcag      360

cugcauccuc agagaggaag ccaggaugcc ccacucugcu ggggguacug cagggguggg      420

gcuggaggcu gcagagccca cagcccugcu caccagggca gagcccccuu cagaacccac      480

agagauccgu ccacaaaagc ggaaaaaggg gccagccccc aaaaugcugg ggaacgagcu      540

augcagcgug uguggggaca aggccucggg cuuccacuac aauguucuga gcugcgaggg      600

cugcaaggga uucuuccgcc gcagcgucau caagggagcg cacuacaucu gccacagugg      660

cggccacugc cccauggaca ccuacaugcg ucgcaagugc caggaguguc ggcuucgcaa      720

augccgucag gcuggcaugc gggaggagug uguccuguca gaagaacaga uccgccugaa      780

gaaacugaag cggcaagagg aggaacaggc ucaugccaca uccuugcccc ccagggcuuc      840

cucacccccc caaauccugc cccagcucag cccggaacaa cugggcauga ucgagaagcu      900

cgucgcugcc cagcaacagu guaaccggcg cuccuuuucu gaccggcuuc gagucacggu      960

gaugcuucug gagacaucuc ggagguacaa cccugggagu gagaguauca ccuuccucaa     1020

ggauuucagu uauaaccggg aagacuuugc caaagcaggg cugcaagugg aauucaucaa     1080

ccccaucuuc gaguucucca gggccaugaa ugagcugcaa cucaaugaug ccgaguuugc     1140

cuugcucauu gcuaucagca ucuucucugc agaccggccc aacgugcagg accagcucca     1200

gguagagagg cugcagcaca cauaugugga agcccugcau gccuacgucu ccauccacca     1260

uccccaugac cgacugaugu ucccacggau gcuaaugaaa cuggugagcc uccggacccu     1320

gagcagcguc cacucagagc aaguguuugc acugcgucug caggacaaaa agcucccacc     1380

gcugcucucu gagaucuggg augugcacga augacuguuc uguccccaua uuuucuguuu     1440

ucuuggccgg auggcugagg ccugguggcu gccuccuaga aguggaacag acugagaagg     1500

gcaaacauuc cugggagcug ggcaaggaga uccucccgug gcauuaaaag agagucaaag     1560

gguugcgagu uuuguggcua cugagcagug gagcccucgc uaacacugug cugugucuga     1620

agaucaugcu gaccccacaa acggaugggc cugggggcca cuuugcacag gguucuccag     1680

agcccugccc auccugccuc caccacuucc uguuuuuccc acagggcccc aagaaaaauu     1740

cuccacuguc aaaaaaaaa                                                  1759


<210>  24
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ser Leu Trp Leu Gly Ala Pro Val Pro Asp Ile Pro Pro Asp Ser 
1               5                   10                  15      


Ala Val Glu Leu Trp Lys Pro Gly Ala Gln Asp Ala Ser Ser Gln Ala 
            20                  25                  30          


Gln Gly Gly Ser Ser Cys Ile Leu Arg Glu Glu Ala Arg Met Pro His 
        35                  40                  45              


Ser Ala Gly Gly Thr Ala Gly Val Gly Leu Glu Ala Ala Glu Pro Thr 
    50                  55                  60                  


Ala Leu Leu Thr Arg Ala Glu Pro Pro Ser Glu Pro Thr Glu Ile Arg 
65                  70                  75                  80  


Pro Gln Lys Arg Lys Lys Gly Pro Ala Pro Lys Met Leu Gly Asn Glu 
                85                  90                  95      


Leu Cys Ser Val Cys Gly Asp Lys Ala Ser Gly Phe His Tyr Asn Val 
            100                 105                 110         


Leu Ser Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Val Ile Lys 
        115                 120                 125             


Gly Ala His Tyr Ile Cys His Ser Gly Gly His Cys Pro Met Asp Thr 
    130                 135                 140                 


Tyr Met Arg Arg Lys Cys Gln Glu Cys Arg Leu Arg Lys Cys Arg Gln 
145                 150                 155                 160 


Ala Gly Met Arg Glu Glu Cys Val Leu Ser Glu Glu Gln Ile Arg Leu 
                165                 170                 175     


Lys Lys Leu Lys Arg Gln Glu Glu Glu Gln Ala His Ala Thr Ser Leu 
            180                 185                 190         


Pro Pro Arg Ala Ser Ser Pro Pro Gln Ile Leu Pro Gln Leu Ser Pro 
        195                 200                 205             


Glu Gln Leu Gly Met Ile Glu Lys Leu Val Ala Ala Gln Gln Gln Cys 
    210                 215                 220                 


Asn Arg Arg Ser Phe Ser Asp Arg Leu Arg Val Thr Val Met Leu Leu 
225                 230                 235                 240 


Glu Thr Ser Arg Arg Tyr Asn Pro Gly Ser Glu Ser Ile Thr Phe Leu 
                245                 250                 255     


Lys Asp Phe Ser Tyr Asn Arg Glu Asp Phe Ala Lys Ala Gly Leu Gln 
            260                 265                 270         


Val Glu Phe Ile Asn Pro Ile Phe Glu Phe Ser Arg Ala Met Asn Glu 
        275                 280                 285             


Leu Gln Leu Asn Asp Ala Glu Phe Ala Leu Leu Ile Ala Ile Ser Ile 
    290                 295                 300                 


Phe Ser Ala Asp Arg Pro Asn Val Gln Asp Gln Leu Gln Val Glu Arg 
305                 310                 315                 320 


Leu Gln His Thr Tyr Val Glu Ala Leu His Ala Tyr Val Ser Ile His 
                325                 330                 335     


His Pro His Asp Arg Leu Met Phe Pro Arg Met Leu Met Lys Leu Val 
            340                 345                 350         


Ser Leu Arg Thr Leu Ser Ser Val His Ser Glu Gln Val Phe Ala Leu 
        355                 360                 365             


Arg Leu Gln Asp Lys Lys Leu Pro Pro Leu Leu Ser Glu Ile Trp Asp 
    370                 375                 380                 


Val His Glu 
385         


<210>  25
<211>  1748
<212>  RNA
<213>  Homo sapiens

<400>  25
aucuuacuua gggaccugcu ggggugcggg gaaaaggcgc agucucggug ggauugcgug       60

caggaggguc guggucuggc uguggcggag gagcauaaga agacucugcg guggagcugu      120

ggaagccagg cgcacaggau gcaagcagcc aggcccaggg aggcagcagc ugcauccuca      180

gagaggaagc caggaugccc cacucugcug gggguacugc aggggugggg cuggaggcug      240

cagagcccac agcccugcuc accagggcag agcccccuuc agaacccaca gagauccguc      300

cacaaaagcg gaaaaagggg ccagccccca aaaugcuggg gaacgagcua ugcagcgugu      360

guggggacaa ggccucgggc uuccacuaca auguucugag cugcgagggc ugcaagggau      420

ucuuccgccg cagcgucauc aagggagcgc acuacaucug ccacaguggc ggccacugcc      480

ccauggacac cuacaugcgu cgcaagugcc aggagugucg gcuucgcaaa ugccgucagg      540

cuggcaugcg ggaggagugu guccugucag aagaacagau ccgccugaag aaacugaagc      600

ggcaagagga ggaacaggcu caugccacau ccuugccccc cagggcuucc ucaccccccc      660

aaauccugcc ccagcucagc ccggaacaac ugggcaugau cgagaagcuc gucgcugccc      720

agcaacagug uaaccggcgc uccuuuucug accggcuucg agucacgccu uggcccaugg      780

caccagaucc ccauagccgg gaggcccguc agcagcgcuu ugcccacuuc acugagcugg      840

ccaucgucuc ugugcaggag auaguugacu uugcuaaaca gcuacccggc uuccugcagc      900

ucagccggga ggaccagauu gcccugcuga agaccucugc gaucgaggug augcuucugg      960

agacaucucg gagguacaac ccugggagug agaguaucac cuuccucaag gauuucaguu     1020

auaaccggga agacuuugcc aaagcagggc ugcaagugga auucaucaac cccaucuucg     1080

aguucuccag ggccaugaau gagcugcaac ucaaugaugc cgaguuugcc uugcucauug     1140

cuaucagcau cuucucugca gaccggccca acgugcagga ccagcuccag guagagaggc     1200

ugcagcacac auauguggaa gcccugcaug ccuacgucuc cauccaccau ccccaugacc     1260

gacugauguu cccacggaug cuaaugaaac uggugagccu ccggacccug agcagcgucc     1320

acucagagca aguguuugca cugcgucugc aggacaaaaa gcucccaccg cugcucucug     1380

agaucuggga ugugcacgaa ugacuguucu guccccauau uuucuguuuu cuuggccgga     1440

uggcugaggc cugguggcug ccuccuagaa guggaacaga cugagaaggg caaacauucc     1500

ugggagcugg gcaaggagau ccucccgugg cauuaaaaga gagucaaagg guugcgaguu     1560

uuguggcuac ugagcagugg agcccucgcu aacacugugc ugugucugaa gaucaugcug     1620

accccacaaa cggaugggcc ugggggccac uuugcacagg guucuccaga gcccugccca     1680

uccugccucc accacuuccu guuuuuccca cagggcccca agaaaaauuc uccacuguca     1740

aaaaaaaa                                                              1748


<210>  26
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Pro His Ser Ala Gly Gly Thr Ala Gly Val Gly Leu Glu Ala Ala 
1               5                   10                  15      


Glu Pro Thr Ala Leu Leu Thr Arg Ala Glu Pro Pro Ser Glu Pro Thr 
            20                  25                  30          


Glu Ile Arg Pro Gln Lys Arg Lys Lys Gly Pro Ala Pro Lys Met Leu 
        35                  40                  45              


Gly Asn Glu Leu Cys Ser Val Cys Gly Asp Lys Ala Ser Gly Phe His 
    50                  55                  60                  


Tyr Asn Val Leu Ser Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser 
65                  70                  75                  80  


Val Ile Lys Gly Ala His Tyr Ile Cys His Ser Gly Gly His Cys Pro 
                85                  90                  95      


Met Asp Thr Tyr Met Arg Arg Lys Cys Gln Glu Cys Arg Leu Arg Lys 
            100                 105                 110         


Cys Arg Gln Ala Gly Met Arg Glu Glu Cys Val Leu Ser Glu Glu Gln 
        115                 120                 125             


Ile Arg Leu Lys Lys Leu Lys Arg Gln Glu Glu Glu Gln Ala His Ala 
    130                 135                 140                 


Thr Ser Leu Pro Pro Arg Ala Ser Ser Pro Pro Gln Ile Leu Pro Gln 
145                 150                 155                 160 


Leu Ser Pro Glu Gln Leu Gly Met Ile Glu Lys Leu Val Ala Ala Gln 
                165                 170                 175     


Gln Gln Cys Asn Arg Arg Ser Phe Ser Asp Arg Leu Arg Val Thr Pro 
            180                 185                 190         


Trp Pro Met Ala Pro Asp Pro His Ser Arg Glu Ala Arg Gln Gln Arg 
        195                 200                 205             


Phe Ala His Phe Thr Glu Leu Ala Ile Val Ser Val Gln Glu Ile Val 
    210                 215                 220                 


Asp Phe Ala Lys Gln Leu Pro Gly Phe Leu Gln Leu Ser Arg Glu Asp 
225                 230                 235                 240 


Gln Ile Ala Leu Leu Lys Thr Ser Ala Ile Glu Val Met Leu Leu Glu 
                245                 250                 255     


Thr Ser Arg Arg Tyr Asn Pro Gly Ser Glu Ser Ile Thr Phe Leu Lys 
            260                 265                 270         


Asp Phe Ser Tyr Asn Arg Glu Asp Phe Ala Lys Ala Gly Leu Gln Val 
        275                 280                 285             


Glu Phe Ile Asn Pro Ile Phe Glu Phe Ser Arg Ala Met Asn Glu Leu 
    290                 295                 300                 


Gln Leu Asn Asp Ala Glu Phe Ala Leu Leu Ile Ala Ile Ser Ile Phe 
305                 310                 315                 320 


Ser Ala Asp Arg Pro Asn Val Gln Asp Gln Leu Gln Val Glu Arg Leu 
                325                 330                 335     


Gln His Thr Tyr Val Glu Ala Leu His Ala Tyr Val Ser Ile His His 
            340                 345                 350         


Pro His Asp Arg Leu Met Phe Pro Arg Met Leu Met Lys Leu Val Ser 
        355                 360                 365             


Leu Arg Thr Leu Ser Ser Val His Ser Glu Gln Val Phe Ala Leu Arg 
    370                 375                 380                 


Leu Gln Asp Lys Lys Leu Pro Pro Leu Leu Ser Glu Ile Trp Asp Val 
385                 390                 395                 400 


His Glu 
        


<210>  27
<211>  1928
<212>  RNA
<213>  Homo sapiens

<400>  27
gauucuaacu uagcuaagca augcuacugg agaccauagg caaagccaag guacagcuuc       60

agggaagucu uuggugagcc caucucucau uaccaaggua acgaagcgca gacuccgggc      120

ccgggugggc ggcaucacca ccagguucac gccgagaagg agcuggagga gagccgcccg      180

gcuccagccg gaccgcuugc ccgccaucac cguuguaauc uaugcagcaa acaagcugga      240

acccgcuggg uggcaccugc aagcagccgc ccggacgcac ccacucugcg guggagcugu      300

ggaagccagg cgcacaggau gcaagcagcc aggcccaggg aggcagcagc ugcauccuca      360

gagaggaagc caggaugccc cacucugcug gggguacugc aggggugggg cuggaggcug      420

cagagcccac agcccugcuc accagggcag agcccccuuc agaacccaca gagauccguc      480

cacaaaagcg gaaaaagggg ccagccccca aaaugcuggg gaacgagcua ugcagcgugu      540

guggggacaa ggccucgggc uuccacuaca auguucugag cugcgagggc ugcaagggau      600

ucuuccgccg cagcgucauc aagggagcgc acuacaucug ccacaguggc ggccacugcc      660

ccauggacac cuacaugcgu cgcaagugcc aggagugucg gcuucgcaaa ugccgucagg      720

cuggcaugcg ggaggagugu guccugucag aagaacagau ccgccugaag aaacugaagc      780

ggcaagagga ggaacaggcu caugccacau ccuugccccc cagggcuucc ucaccccccc      840

aaauccugcc ccagcucagc ccggaacaac ugggcaugau cgagaagcuc gucgcugccc      900

agcaacagug uaaccggcgc uccuuuucug accggcuucg agucacgccu uggcccaugg      960

caccagaucc ccauagccgg gaggcccguc agcagcgcuu ugcccacuuc acugagcugg     1020

ccaucgucuc ugugcaggag auaguugacu uugcuaaaca gcuacccggc uuccugcagc     1080

ucagccggga ggaccagauu gcccugcuga agaccucugc gaucgaggug augcuucugg     1140

agacaucucg gagguacaac ccugggagug agaguaucac cuuccucaag gauuucaguu     1200

auaaccggga agacuuugcc aaagcagggc ugcaagugga auucaucaac cccaucuucg     1260

aguucuccag ggccaugaau gagcugcaac ucaaugaugc cgaguuugcc uugcucauug     1320

cuaucagcau cuucucugca gaccggccca acgugcagga ccagcuccag guagagaggc     1380

ugcagcacac auauguggaa gcccugcaug ccuacgucuc cauccaccau ccccaugacc     1440

gacugauguu cccacggaug cuaaugaaac uggugagccu ccggacccug agcagcgucc     1500

acucagagca aguguuugca cugcgucugc aggacaaaaa gcucccaccg cugcucucug     1560

agaucuggga ugugcacgaa ugacuguucu guccccauau uuucuguuuu cuuggccgga     1620

uggcugaggc cugguggcug ccuccuagaa guggaacaga cugagaaggg caaacauucc     1680

ugggagcugg gcaaggagau ccucccgugg cauuaaaaga gagucaaagg guugcgaguu     1740

uuguggcuac ugagcagugg agcccucgcu aacacugugc ugugucugaa gaucaugcug     1800

accccacaaa cggaugggcc ugggggccac uuugcacagg guucuccaga gcccugccca     1860

uccugccucc accacuuccu guuuuuccca cagggcccca agaaaaauuc uccacuguca     1920

aaaaaaaa                                                              1928


<210>  28
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Gln Gln Thr Ser Trp Asn Pro Leu Gly Gly Thr Cys Lys Gln Pro 
1               5                   10                  15      


Pro Gly Arg Thr His Ser Ala Val Glu Leu Trp Lys Pro Gly Ala Gln 
            20                  25                  30          


Asp Ala Ser Ser Gln Ala Gln Gly Gly Ser Ser Cys Ile Leu Arg Glu 
        35                  40                  45              


Glu Ala Arg Met Pro His Ser Ala Gly Gly Thr Ala Gly Val Gly Leu 
    50                  55                  60                  


Glu Ala Ala Glu Pro Thr Ala Leu Leu Thr Arg Ala Glu Pro Pro Ser 
65                  70                  75                  80  


Glu Pro Thr Glu Ile Arg Pro Gln Lys Arg Lys Lys Gly Pro Ala Pro 
                85                  90                  95      


Lys Met Leu Gly Asn Glu Leu Cys Ser Val Cys Gly Asp Lys Ala Ser 
            100                 105                 110         


Gly Phe His Tyr Asn Val Leu Ser Cys Glu Gly Cys Lys Gly Phe Phe 
        115                 120                 125             


Arg Arg Ser Val Ile Lys Gly Ala His Tyr Ile Cys His Ser Gly Gly 
    130                 135                 140                 


His Cys Pro Met Asp Thr Tyr Met Arg Arg Lys Cys Gln Glu Cys Arg 
145                 150                 155                 160 


Leu Arg Lys Cys Arg Gln Ala Gly Met Arg Glu Glu Cys Val Leu Ser 
                165                 170                 175     


Glu Glu Gln Ile Arg Leu Lys Lys Leu Lys Arg Gln Glu Glu Glu Gln 
            180                 185                 190         


Ala His Ala Thr Ser Leu Pro Pro Arg Ala Ser Ser Pro Pro Gln Ile 
        195                 200                 205             


Leu Pro Gln Leu Ser Pro Glu Gln Leu Gly Met Ile Glu Lys Leu Val 
    210                 215                 220                 


Ala Ala Gln Gln Gln Cys Asn Arg Arg Ser Phe Ser Asp Arg Leu Arg 
225                 230                 235                 240 


Val Thr Pro Trp Pro Met Ala Pro Asp Pro His Ser Arg Glu Ala Arg 
                245                 250                 255     


Gln Gln Arg Phe Ala His Phe Thr Glu Leu Ala Ile Val Ser Val Gln 
            260                 265                 270         


Glu Ile Val Asp Phe Ala Lys Gln Leu Pro Gly Phe Leu Gln Leu Ser 
        275                 280                 285             


Arg Glu Asp Gln Ile Ala Leu Leu Lys Thr Ser Ala Ile Glu Val Met 
    290                 295                 300                 


Leu Leu Glu Thr Ser Arg Arg Tyr Asn Pro Gly Ser Glu Ser Ile Thr 
305                 310                 315                 320 


Phe Leu Lys Asp Phe Ser Tyr Asn Arg Glu Asp Phe Ala Lys Ala Gly 
                325                 330                 335     


Leu Gln Val Glu Phe Ile Asn Pro Ile Phe Glu Phe Ser Arg Ala Met 
            340                 345                 350         


Asn Glu Leu Gln Leu Asn Asp Ala Glu Phe Ala Leu Leu Ile Ala Ile 
        355                 360                 365             


Ser Ile Phe Ser Ala Asp Arg Pro Asn Val Gln Asp Gln Leu Gln Val 
    370                 375                 380                 


Glu Arg Leu Gln His Thr Tyr Val Glu Ala Leu His Ala Tyr Val Ser 
385                 390                 395                 400 


Ile His His Pro His Asp Arg Leu Met Phe Pro Arg Met Leu Met Lys 
                405                 410                 415     


Leu Val Ser Leu Arg Thr Leu Ser Ser Val His Ser Glu Gln Val Phe 
            420                 425                 430         


Ala Leu Arg Leu Gln Asp Lys Lys Leu Pro Pro Leu Leu Ser Glu Ile 
        435                 440                 445             


Trp Asp Val His Glu 
    450             


<210>  29
<211>  2093
<212>  RNA
<213>  Homo sapiens

<400>  29
ucgucaaguu ucacgcuccg ccccucuucc ggacgugacg caagggcggg guugccggaa       60

gaaguggcga aguuacuuuu gaggguauuu gaguagcggc ggugugucag gggcuaaaga      120

ggaggacgaa gaaaagcaga gcaagggaac ccagggcaac aggaguaguu cacuccgcga      180

gaggccgucc acgagacccc cgcgcgcagc caugagcccc gccccccgcu guugcuugga      240

gaggggcggg accuggagag aggcugcucc gugaccccac cauguccucu ccuaccacga      300

guucccugga uaccccccug ccuggaaaug gccccccuca gccuggcgcc ccuucuucuu      360

cacccacugu aaaggaggag gguccggagc cguggcccgg ggguccggac ccugaugucc      420

caggcacuga ugaggccagc ucagccugca gcacagacug ggucauccca gaucccgaag      480

aggaaccaga gcgcaagcga aagaagggcc cagccccgaa gaugcugggc cacgagcuuu      540

gccgugucug uggggacaag gccuccggcu uccacuacaa cgugcucagc ugcgaaggcu      600

gcaagggcuu cuuccggcgc aguguggucc gugguggggc caggcgcuau gccugccggg      660

guggcggaac cugccagaug gacgcuuuca ugcggcgcaa gugccagcag ugccggcugc      720

gcaagugcaa ggaggcaggg augagggagc agugcguccu uucugaagaa cagauccgga      780

agaagaagau ucggaaacaa cagcagcagg agucacaguc acagucgcag ucaccugugg      840

ggccgcaggg cagcagcagc ucagccucug ggccuggggc uuccccuggu ggaucugagg      900

caggcagcca gggcuccggg gaaggcgagg guguccagcu aacagcggcu caagaacuaa      960

ugauccagca guugguggcg gcccaacugc agugcaacaa acgcuccuuc uccgaccagc     1020

ccaaagucac gcccuggccc cugggcgcag acccccaguc ccgagaugcc cgccagcaac     1080

gcuuugccca cuucacggag cuggccauca ucucagucca ggagaucgug gacuucgcua     1140

agcaagugcc ugguuuccug cagcugggcc gggaggacca gaucgcccuc cugaaggcau     1200

ccacuaucga gaucaugcug cuagagacag ccaggcgcua caaccacgag acagagugua     1260

ucaccuucuu gaaggacuuc accuacagca aggacgacuu ccaccgugca ggccugcagg     1320

uggaguucau caaccccauc uucgaguucu cgcgggccau gcggcggcug ggccuggacg     1380

acgcugagua cgcccugcuc aucgccauca acaucuucuc ggccgaccgg cccaacgugc     1440

aggagccggg ccgcguggag gcguugcagc agcccuacgu ggaggcgcug cuguccuaca     1500

cgcgcaucaa gaggccgcag gaccagcugc gcuucccgcg caugcucaug aagcugguga     1560

gccugcgcac gcugagcucu gugcacucgg agcaggucuu cgccuugcgg cuccaggaca     1620

agaagcugcc gccucugcug ucggagaucu gggacgucca cgagugaggg gcuggccacc     1680

cagccccaca gccuugccug accacccucc agcagauaga cgccggcacc ccuuccucuu     1740

ccuagggugg aaggggcccu gggccgagcc uguagaccua ucggcucuca ucccuuggga     1800

uaagccccag uccaggucca ggaggcuccc ucccugccca gcgagucuuc cagaaggggu     1860

gaaaggguug caggucccga ccacugaccc uucccggcug cccucccucc ccagcuuaca     1920

ccucaagccc agcacgcagu gcaccuugaa cagagggagg ggaggaccca uggcucuccc     1980

cccuagcccg ggagaccagg gccuuccucu uccucugcuu uuauuuaaua aaaacuaaaa     2040

acagaaacag gaaaauaaaa uaugaauaca auccagcccg gagcuggagu gca            2093


<210>  30
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ser Ser Pro Thr Thr Ser Ser Leu Asp Thr Pro Leu Pro Gly Asn 
1               5                   10                  15      


Gly Pro Pro Gln Pro Gly Ala Pro Ser Ser Ser Pro Thr Val Lys Glu 
            20                  25                  30          


Glu Gly Pro Glu Pro Trp Pro Gly Gly Pro Asp Pro Asp Val Pro Gly 
        35                  40                  45              


Thr Asp Glu Ala Ser Ser Ala Cys Ser Thr Asp Trp Val Ile Pro Asp 
    50                  55                  60                  


Pro Glu Glu Glu Pro Glu Arg Lys Arg Lys Lys Gly Pro Ala Pro Lys 
65                  70                  75                  80  


Met Leu Gly His Glu Leu Cys Arg Val Cys Gly Asp Lys Ala Ser Gly 
                85                  90                  95      


Phe His Tyr Asn Val Leu Ser Cys Glu Gly Cys Lys Gly Phe Phe Arg 
            100                 105                 110         


Arg Ser Val Val Arg Gly Gly Ala Arg Arg Tyr Ala Cys Arg Gly Gly 
        115                 120                 125             


Gly Thr Cys Gln Met Asp Ala Phe Met Arg Arg Lys Cys Gln Gln Cys 
    130                 135                 140                 


Arg Leu Arg Lys Cys Lys Glu Ala Gly Met Arg Glu Gln Cys Val Leu 
145                 150                 155                 160 


Ser Glu Glu Gln Ile Arg Lys Lys Lys Ile Arg Lys Gln Gln Gln Gln 
                165                 170                 175     


Glu Ser Gln Ser Gln Ser Gln Ser Pro Val Gly Pro Gln Gly Ser Ser 
            180                 185                 190         


Ser Ser Ala Ser Gly Pro Gly Ala Ser Pro Gly Gly Ser Glu Ala Gly 
        195                 200                 205             


Ser Gln Gly Ser Gly Glu Gly Glu Gly Val Gln Leu Thr Ala Ala Gln 
    210                 215                 220                 


Glu Leu Met Ile Gln Gln Leu Val Ala Ala Gln Leu Gln Cys Asn Lys 
225                 230                 235                 240 


Arg Ser Phe Ser Asp Gln Pro Lys Val Thr Pro Trp Pro Leu Gly Ala 
                245                 250                 255     


Asp Pro Gln Ser Arg Asp Ala Arg Gln Gln Arg Phe Ala His Phe Thr 
            260                 265                 270         


Glu Leu Ala Ile Ile Ser Val Gln Glu Ile Val Asp Phe Ala Lys Gln 
        275                 280                 285             


Val Pro Gly Phe Leu Gln Leu Gly Arg Glu Asp Gln Ile Ala Leu Leu 
    290                 295                 300                 


Lys Ala Ser Thr Ile Glu Ile Met Leu Leu Glu Thr Ala Arg Arg Tyr 
305                 310                 315                 320 


Asn His Glu Thr Glu Cys Ile Thr Phe Leu Lys Asp Phe Thr Tyr Ser 
                325                 330                 335     


Lys Asp Asp Phe His Arg Ala Gly Leu Gln Val Glu Phe Ile Asn Pro 
            340                 345                 350         


Ile Phe Glu Phe Ser Arg Ala Met Arg Arg Leu Gly Leu Asp Asp Ala 
        355                 360                 365             


Glu Tyr Ala Leu Leu Ile Ala Ile Asn Ile Phe Ser Ala Asp Arg Pro 
    370                 375                 380                 


Asn Val Gln Glu Pro Gly Arg Val Glu Ala Leu Gln Gln Pro Tyr Val 
385                 390                 395                 400 


Glu Ala Leu Leu Ser Tyr Thr Arg Ile Lys Arg Pro Gln Asp Gln Leu 
                405                 410                 415     


Arg Phe Pro Arg Met Leu Met Lys Leu Val Ser Leu Arg Thr Leu Ser 
            420                 425                 430         


Ser Val His Ser Glu Gln Val Phe Ala Leu Arg Leu Gln Asp Lys Lys 
        435                 440                 445             


Leu Pro Pro Leu Leu Ser Glu Ile Trp Asp Val His Glu 
    450                 455                 460     


<210>  31
<211>  1802
<212>  RNA
<213>  Homo sapiens

<400>  31
ucgucaaguu ucacgcuccg ccccucuucc ggacgugacg caagggcggg guugccggaa       60

gaaguggcga aguuacuuuu gaggguauuu gaguagcggc ggugugucag gggcuaaaga      120

ggaggacgaa gaaaagcaga gcaagggaac ccagggcaac aggaguaguu cacuccgcga      180

gaggccgucc acgagacccc cgcgcgcagc caugagcccc gccccccgcu guugcuugga      240

gaggggcggg accuggagag aggcugcucc gugaccccac cauguccucu ccuaccacga      300

guucccugga uaccccccug ccuggaaaug gccccccuca gccuggcgcc ccuucuucuu      360

cacccacugu aaaggaggag gguccggagc cguggcccgg ggguccggac ccugaugucc      420

caggcacuga ugaggccagc ucagccugca gcacagacug gggcguccuu ucugaagaac      480

agauccggaa gaagaagauu cggaaacaac agcagcagga gucacaguca cagucgcagu      540

caccuguggg gccgcagggc agcagcagcu cagccucugg gccuggggcu uccccuggug      600

gaucugaggc aggcagccag ggcuccgggg aaggcgaggg uguccagcua acagcggcuc      660

aagaacuaau gauccagcag uugguggcgg cccaacugca gugcaacaaa cgcuccuucu      720

ccgaccagcc caaagucacg cccuggcccc ugggcgcaga cccccagucc cgagaugccc      780

gccagcaacg cuuugcccac uucacggagc uggccaucau cucaguccag gagaucgugg      840

acuucgcuaa gcaagugccu gguuuccugc agcugggccg ggaggaccag aucgcccucc      900

ugaaggcauc cacuaucgag aucaugcugc uagagacagc caggcgcuac aaccacgaga      960

cagaguguau caccuucuug aaggacuuca ccuacagcaa ggacgacuuc caccgugcag     1020

gccugcaggu ggaguucauc aaccccaucu ucgaguucuc gcgggccaug cggcggcugg     1080

gccuggacga cgcugaguac gcccugcuca ucgccaucaa caucuucucg gccgaccggc     1140

ccaacgugca ggagccgggc cgcguggagg cguugcagca gcccuacgug gaggcgcugc     1200

uguccuacac gcgcaucaag aggccgcagg accagcugcg cuucccgcgc augcucauga     1260

agcuggugag ccugcgcacg cugagcucug ugcacucgga gcaggucuuc gccuugcggc     1320

uccaggacaa gaagcugccg ccucugcugu cggagaucug ggacguccac gagugagggg     1380

cuggccaccc agccccacag ccuugccuga ccacccucca gcagauagac gccggcaccc     1440

cuuccucuuc cuagggugga aggggcccug ggccgagccu guagaccuau cggcucucau     1500

cccuugggau aagccccagu ccagguccag gaggcucccu cccugcccag cgagucuucc     1560

agaaggggug aaaggguugc aggucccgac cacugacccu ucccggcugc ccucccuccc     1620

cagcuuacac cucaagccca gcacgcagug caccuugaac agagggaggg gaggacccau     1680

ggcucucccc ccuagcccgg gagaccaggg ccuuccucuu ccucugcuuu uauuuaauaa     1740

aaacuaaaaa cagaaacagg aaaauaaaau augaauacaa uccagcccgg agcuggagug     1800

ca                                                                    1802


<210>  32
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ser Ser Pro Thr Thr Ser Ser Leu Asp Thr Pro Leu Pro Gly Asn 
1               5                   10                  15      


Gly Pro Pro Gln Pro Gly Ala Pro Ser Ser Ser Pro Thr Val Lys Glu 
            20                  25                  30          


Glu Gly Pro Glu Pro Trp Pro Gly Gly Pro Asp Pro Asp Val Pro Gly 
        35                  40                  45              


Thr Asp Glu Ala Ser Ser Ala Cys Ser Thr Asp Trp Gly Val Leu Ser 
    50                  55                  60                  


Glu Glu Gln Ile Arg Lys Lys Lys Ile Arg Lys Gln Gln Gln Gln Glu 
65                  70                  75                  80  


Ser Gln Ser Gln Ser Gln Ser Pro Val Gly Pro Gln Gly Ser Ser Ser 
                85                  90                  95      


Ser Ala Ser Gly Pro Gly Ala Ser Pro Gly Gly Ser Glu Ala Gly Ser 
            100                 105                 110         


Gln Gly Ser Gly Glu Gly Glu Gly Val Gln Leu Thr Ala Ala Gln Glu 
        115                 120                 125             


Leu Met Ile Gln Gln Leu Val Ala Ala Gln Leu Gln Cys Asn Lys Arg 
    130                 135                 140                 


Ser Phe Ser Asp Gln Pro Lys Val Thr Pro Trp Pro Leu Gly Ala Asp 
145                 150                 155                 160 


Pro Gln Ser Arg Asp Ala Arg Gln Gln Arg Phe Ala His Phe Thr Glu 
                165                 170                 175     


Leu Ala Ile Ile Ser Val Gln Glu Ile Val Asp Phe Ala Lys Gln Val 
            180                 185                 190         


Pro Gly Phe Leu Gln Leu Gly Arg Glu Asp Gln Ile Ala Leu Leu Lys 
        195                 200                 205             


Ala Ser Thr Ile Glu Ile Met Leu Leu Glu Thr Ala Arg Arg Tyr Asn 
    210                 215                 220                 


His Glu Thr Glu Cys Ile Thr Phe Leu Lys Asp Phe Thr Tyr Ser Lys 
225                 230                 235                 240 


Asp Asp Phe His Arg Ala Gly Leu Gln Val Glu Phe Ile Asn Pro Ile 
                245                 250                 255     


Phe Glu Phe Ser Arg Ala Met Arg Arg Leu Gly Leu Asp Asp Ala Glu 
            260                 265                 270         


Tyr Ala Leu Leu Ile Ala Ile Asn Ile Phe Ser Ala Asp Arg Pro Asn 
        275                 280                 285             


Val Gln Glu Pro Gly Arg Val Glu Ala Leu Gln Gln Pro Tyr Val Glu 
    290                 295                 300                 


Ala Leu Leu Ser Tyr Thr Arg Ile Lys Arg Pro Gln Asp Gln Leu Arg 
305                 310                 315                 320 


Phe Pro Arg Met Leu Met Lys Leu Val Ser Leu Arg Thr Leu Ser Ser 
                325                 330                 335     


Val His Ser Glu Gln Val Phe Ala Leu Arg Leu Gln Asp Lys Lys Leu 
            340                 345                 350         


Pro Pro Leu Leu Ser Glu Ile Trp Asp Val His Glu 
        355                 360                 


<210>  33
<211>  71
<212>  RNA
<213>  Homo sapiens

<400>  33
gccaacccag uguucagacu accuguucag gaggcucuca auguguacag uagucugcac       60

auugguuagg c                                                            71


<210>  34
<211>  110
<212>  RNA
<213>  Homo sapiens

<400>  34
aggaagcuuc uggagauccu gcuccgucgc cccaguguuc agacuaccug uucaggacaa       60

ugccguugua caguagucug cacauugguu agacugggca agggagagca                 110


<210>  35
<211>  80
<212>  RNA
<213>  Homo sapiens

<400>  35
cgggaaugcc gcggcgggga cggcgauugg uccguaugug uggugccacc ggccgccggc       60

uccgccccgg cccccgcccc                                                   80


<210>  36
<211>  110
<212>  RNA
<213>  Homo sapiens

<400>  36
uuggauguug gccuaguucu guguggaaga cuagugauuu uguuguuuuu agauaacuaa       60

aucgacaaca aaucacaguc ugccauaugg cacaggccau gccucuacag                 110


<210>  37
<211>  110
<212>  RNA
<213>  Homo sapiens

<400>  37
cuggauacag aguggaccgg cuggccccau cuggaagacu agugauuuug uuguugucuu       60

acugcgcuca acaacaaauc ccagucuacc uaauggugcc agccaucgca                 110


<210>  38
<211>  110
<212>  RNA
<213>  Homo sapiens

<400>  38
agauuagagu ggcugugguc uagugcugug uggaagacua gugauuuugu uguucugaug       60

uacuacgaca acaagucaca gccggccuca uagcgcagac ucccuucgac                 110


<210>  39
<211>  71
<212>  DNA
<213>  Homo sapiens

<400>  39
gatccgacag tagcctgcac attagtcact tcctgtcagt aaccaatgtg cagactactg       60

ttttttgaat t                                                            71


<210>  40
<211>  73
<212>  DNA
<213>  Homo sapiens

<400>  40
gatccgccca gtgctcagac tacccgtgcc ttcctgtcag gaacaggtag tctgaacact       60

gggtttttga att                                                          73


<210>  41
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  41
gatccgcggc gggaacggcg atcggccctt cctgtcagga ccaatcgccg tccccgccgt       60

ttttgaatt                                                               69


<210>  42
<211>  73
<212>  DNA
<213>  Homo sapiens

<400>  42
gatccgtgga agattagtga gtttattatc ttcctgtcag acaacaaaat cactagtctt       60

ccatttttga att                                                          73


<210>  43
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  43

Thr Gln Gln Ile Arg Leu Gln Ala Glu Ile Phe Gln Ala Arg 
1               5                   10                  


<210>  44
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  44

Ala Gln Gln Ile Arg Leu Gln Ala Glu Ala Phe Gln Ala Arg 
1               5                   10                  


<210>  45
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  45

Thr Ala Gln Ile Arg Leu Gln Ala Glu Ile Phe Gln Ala Arg 
1               5                   10                  


<210>  46
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  46

Thr Gln Ala Ile Arg Leu Gln Ala Glu Ile Phe Gln Ala Arg 
1               5                   10                  


<210>  47
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  47

Thr Gln Gln Ala Arg Leu Gln Ala Glu Ile Phe Gln Ala Arg 
1               5                   10                  


<210>  48
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  48

Thr Gln Gln Ile Ala Leu Gln Ala Glu Ile Phe Gln Ala Arg 
1               5                   10                  


<210>  49
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  49

Gln Thr Gln Gln Ile Arg Leu Gln Ala Glu Ile Phe Gln Ala Arg 
1               5                   10                  15  


<210>  50
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  50

Gln Gln Ile Arg Leu Gln Ala Glu Ile Phe Gln Ala Arg 
1               5                   10              


<210>  51
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic shAPOE

<400>  51
ccgggaagga gttgaaggcc tacaactcga gttgtaggcc ttcaactcct tcttttt          57


<210>  52
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic shAPOE

<400>  52
ccgggcagac actgtctgag caggtctcga gacctgctca gacagtgtct gcttttt          57


<210>  53
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic shDNAJA

<400>  53
ccgggcgaga agtttaaact catatctcga gatatgagtt taaacttctc gcttttt          57


<210>  54
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic shDNAJA4

<400>  54
ccggcctcga cagaaagtga ggattctcga gaatcctcac tttctgtcga ggttttt          57


<210>  55
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic ApoE Forward Primer

<400>  55
tcatgaggat ccatgaaggt tctgtgggct                                        30


<210>  56
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic ApoE Reverse Primer

<400>  56
tagcagaatt ctcagtgatt gtcgctggg                                         29


<210>  57
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNAJA4 Forward Primer

<400>  57
atccctggat ccatgtggga aagcctgacc c                                      31


<210>  58
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNAJA4 Reverse Primer

<400>  58
taccatgtcg actcatgccg tctggcactg c                                      31


<210>  59
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic LRP1 target sequence

<400>  59
cgaggacgau gacugcuua                                                    19


<210>  60
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic LRP1 target sequence

<400>  60
gcuaugaguu uaagaaguu                                                    19


<210>  61
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic LRP8 target sequence

<400>  61
cgaggacgau gacugcuua                                                    19


<210>  62
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic LRP8 target sequence

<400>  62
gaacuauuca cgccucauc                                                    19


<210>  63
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic ApoE Forward Primer

<400>  63
tgggtcgctt ttgggattac                                                   20


<210>  64
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic ApoE Reverse Primer

<400>  64
ttcaactcct tcatggtctc g                                                 21


<210>  65
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNAJA4 Forward Primer

<400>  65
ccagcttctc ttcacccatg                                                   20


<210>  66
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNAJA4 Reverse Primer

<400>  66
gccaatttct tcgtgactcc                                                   20


<210>  67
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic GAPDH Forward Primer

<400>  67
agccacatcg ctcagacac                                                    19


<210>  68
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic GAPDH Synthetic Primer

<400>  68
gcccaatacg accaaatcc                                                    19


<210>  69
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic LRP1 Forward Primer

<400>  69
tttaacagca ccgagtacca g                                                 21


<210>  70
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic LRP1 Reverse Primer

<400>  70
caggcagatg tcagagcag                                                    19


<210>  71
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic LRP8 Forward Primer

<400>  71
gctaccctgg ctacgagatg                                                   20


<210>  72
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic LRP8 Reverse Primer

<400>  72
gattagggat gggctcttgc                                                   20


<210>  73
<211>  8
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic miRNA seed sequence

<400>  73
caguaguc                                                                 8


<210>  74
<211>  8
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic miRNA seed sequence

<400>  74
ccaguguu                                                                 8


<210>  75
<211>  8
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic miRNA seed sequence

<400>  75
ggcgggga                                                                 8


<210>  76
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Primer

<400>  76
agtacctcga ggggatcctt gagtcctact c                                      31


<210>  77
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Primer

<400>  77
taattgcggc cgctcagaca gtgtctgcac ccag                                   34


<210>  78
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Primer

<400>  78
taatatctcg agatgtggga aagcctgacc c                                      31


<210>  79
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Primer

<400>  79
caattgcggc cgctcatgcc gtctggcact gc                                     32


<210>  80
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Primer

<400>  80
ttagcctcga gacgccgaag cctgcagcca                                        30


<210>  81
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Primer

<400>  81
ttactgcggc cgctgcgtga aacttggtga atctt                                  35


<210>  82
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Primer

<400>  82
taatatctcg agcgtggtgc ggggcagcgt                                        30


<210>  83
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Primer

<400>  83
caattgcggc cgcttatctc tcataccagc tcaat                                  35


<210>  84
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Primer

<400>  84
gccagcgctg ggaactggca actggtcgct tttgggatta cct                         43


<210>  85
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Primer

<400>  85
cagcgggaga ccctgtcccc ataccagccg tcctcctggg gtg                         43


<210>  86
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Primer

<400>  86
tccccgcccc agccgtcctc acagggtgga ccctagttta ata                         43


<210>  87
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Primer

<400>  87
gggatcggtg gagaagtgcc tattgtgcaa ggggcggggg atg                         43


<210>  88
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Primer

<400>  88
gtagggggcg gggaacgtgt tatccgtgaa gaggtggcta ggg                         43


<210>  89
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Primer

<400>  89
cagggccaac ttagttccta acattctgtg cccttcagtg gat                         43


<210>  90
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Primer

<400>  90
acagtttgta tggactacta tcttaaatta tagcttgttt gga                         43


<210>  91
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Primer

<400>  91
taattattgc taaagaacta tgttttagtt ggtaatggtg taa                         43


<210>  92
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Primer

<400>  92
cagctgcacg gaccaggttc cataaaaaca ttgccagcta gtgag                       45


<210>  93
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  93
tgagtatttt tgtggcaact gc                                                22


<210>  94
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  94
ctctgctggg aaagcggc                                                     18


<210>  95
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  95
caagcactct gcgaactgag                                                   20


<210>  96
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  96
aagtttttga aggcaagatg c                                                 21


<210>  97
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  97
gcggtctggc agtaaaaact atc                                               23


<210>  98
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  98
gtgaaacagc attgctgtca ctt                                               23


<210>  99
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  99
ctaggccaca gaattgaaag atct                                              24


<210>  100
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  100
gtaggtggaa attctagcat catcc                                             25


<210>  101
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  101
gcctagccga gggagagccg                                                   20


<210>  102
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  102
tgtgacttgg gagctctgca gc                                                22


<210>  103
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  103
gccgccccga ctgcatct                                                     18


<210>  104
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  104
tcagtggagg gaaggaaatg                                                   20


<210>  105
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  105
ttcctgccct ggacacttac                                                   20


<210>  106
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  106
ttgtgcccag tcatagccga at                                                22


<210>  107
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  107
ccttttctcc ctgacaccg                                                    19


<210>  108
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  108
gcatccatct ggcaggttc                                                    19


<210>  109
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  109
aggtgagatg acaggagatc                                                   20


<210>  110
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  110
ccggccgact gatgttccca cggatctcga gatccgtggg aacatcagtc ggttttt          57


<210>  111
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  111
ccgggcaact caatgatgcc gagttctcga gaactcggca tcattgagtt gcttttt          57


<210>  112
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  112
ccggagagtg tatcaccttc ttgaactcga gttcaagaag gtgatacact ctttttt          57


<210>  113
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  113
ccgggaaggc atccactatc gagatctcga gatctcgata gtggatgcct tcttttt          57


<210>  114
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  114
ccgggcagac actgtctgag caggtctcga gacctgctca gacagtgtct gcttttt          57


<210>  115
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  115
ccgggcaact caatgatgct gagttctcga gaactcagca tcattgagtt gcttttt          57


<210>  116
<211>  58
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  116
ccggtgagat catgttgcta gaaacctcga ggtttctagc aacatgatct catttttg         58


<210>  117
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  117
ccgggaggac actatgacgg aagtactcga gtacttccgt catagtgtcc tcttttt          57


<210>  118
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  118
tgggtcgctt ttgggattac                                                   20


<210>  119
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  119
ttcaactcct tcatggtctc g                                                 21


<210>  120
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  120
agccacatcg ctcagacac                                                    19


<210>  121
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  121
gcccaatacg accaaatcc                                                    19


<210>  122
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  122
gttataaccg ggaagacttt gc                                                22


<210>  123
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  123
aaactcggca tcattgagtt g                                                 21


<210>  124
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  124
tttgagggta tttgagtagc gg                                                22


<210>  125
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  125
ctctcgcgga gtgaactac                                                    19


<210>  126
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  126
gaccctggag gctaaggact                                                   20


<210>  127
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  127
agagccttca tcttcgcaat                                                   20


<210>  128
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  128
gcacagtcaa ggccgagaat                                                   20


<210>  129
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  129
gccttctcca tggtggtgaa                                                   20


<210>  130
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  130
gcgctcagct cttgtcact                                                    19


<210>  131
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  131
ctccagccac aaggacatct                                                   20


<210>  132
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  132
gctctgccta catcgtggtc                                                   20


<210>  133
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  133
ctcatggccc agcatctt                                                     18


<210>  134
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  134
atggagcagg gaagaccac                                                    19


<210>  135
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  135
gtaggccgtg ccagaagtt                                                    19


<210>  136
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  136
tcatagctag cgcagagcca ggattcacgc cctg                                   34


<210>  137
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  137
tggtcctcga ggaaccttca tcttcctgcc tgtga                                  35


<210>  138
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  138
tagttacgcg tagtagcccc catctttgcc                                        30


<210>  139
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  139
aatcagctag cccctcagct gcaaagctc                                         29


<210>  140
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  140
tagttacgcg tagtagcccc ctctttgcc                                         29


<210>  141
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  141
aatcagctag cccttcagct gcaaagctct g                                      31


