                         SEQUENCE LISTING

<110>  CNIC Fundacin Centro Nacional de Investigaciones 
       Cardiovasculares Carlos III.
       EMBL European Molecular Biology Laboratory.
 
<120>  Methods of using the calcineurin A variant CnAB1 for the 
       treatment of cardiac hypertrophy.

<130>  157642

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  496
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(496)
<223>  Human CnAbeta1 aa sequence

<400>  1

Met Ala Ala Pro Glu Pro Ala Arg Ala Ala Pro Pro Pro Pro Pro Pro 
1               5                   10                  15      


Pro Pro Pro Pro Pro Gly Ala Asp Arg Val Val Lys Ala Val Pro Phe 
            20                  25                  30          


Pro Pro Thr His Arg Leu Thr Ser Glu Glu Val Phe Asp Leu Asp Gly 
        35                  40                  45              


Ile Pro Arg Val Asp Val Leu Lys Asn His Leu Val Lys Glu Gly Arg 
    50                  55                  60                  


Val Asp Glu Glu Ile Ala Leu Arg Ile Ile Asn Glu Gly Ala Ala Ile 
65                  70                  75                  80  


Leu Arg Arg Glu Lys Thr Met Ile Glu Val Glu Ala Pro Ile Thr Val 
                85                  90                  95      


Cys Gly Asp Ile His Gly Gln Phe Phe Asp Leu Met Lys Leu Phe Glu 
            100                 105                 110         


Val Gly Gly Ser Pro Ala Asn Thr Arg Tyr Leu Phe Leu Gly Asp Tyr 
        115                 120                 125             


Val Asp Arg Gly Tyr Phe Ser Ile Glu Cys Val Leu Tyr Leu Trp Val 
    130                 135                 140                 


Leu Lys Ile Leu Tyr Pro Ser Thr Leu Phe Leu Leu Arg Gly Asn His 
145                 150                 155                 160 


Glu Cys Arg His Leu Thr Glu Tyr Phe Thr Phe Lys Gln Glu Cys Lys 
                165                 170                 175     


Ile Lys Tyr Ser Glu Arg Val Tyr Glu Ala Cys Met Glu Ala Phe Asp 
            180                 185                 190         


Ser Leu Pro Leu Ala Ala Leu Leu Asn Gln Gln Phe Leu Cys Val His 
        195                 200                 205             


Gly Gly Leu Ser Pro Glu Ile His Thr Leu Asp Asp Ile Arg Arg Leu 
    210                 215                 220                 


Asp Arg Phe Lys Glu Pro Pro Ala Phe Gly Pro Met Cys Asp Leu Leu 
225                 230                 235                 240 


Trp Ser Asp Pro Ser Glu Asp Phe Gly Asn Glu Lys Ser Gln Glu His 
                245                 250                 255     


Phe Ser His Asn Thr Val Arg Gly Cys Ser Tyr Phe Tyr Asn Tyr Pro 
            260                 265                 270         


Ala Val Cys Glu Phe Leu Gln Asn Asn Asn Leu Leu Ser Ile Ile Arg 
        275                 280                 285             


Ala His Glu Ala Gln Asp Ala Gly Tyr Arg Met Tyr Arg Lys Ser Gln 
    290                 295                 300                 


Thr Thr Gly Phe Pro Ser Leu Ile Thr Ile Phe Ser Ala Pro Asn Tyr 
305                 310                 315                 320 


Leu Asp Val Tyr Asn Asn Lys Ala Ala Val Leu Lys Tyr Glu Asn Asn 
                325                 330                 335     


Val Met Asn Ile Arg Gln Phe Asn Cys Ser Pro His Pro Tyr Trp Leu 
            340                 345                 350         


Pro Asn Phe Met Asp Val Phe Thr Trp Ser Leu Pro Phe Val Gly Glu 
        355                 360                 365             


Lys Val Thr Glu Met Leu Val Asn Val Leu Ser Ile Cys Ser Asp Asp 
    370                 375                 380                 


Glu Leu Met Thr Glu Gly Glu Asp Gln Phe Asp Gly Ser Ala Ala Ala 
385                 390                 395                 400 


Arg Lys Glu Ile Ile Arg Asn Lys Ile Arg Ala Ile Gly Lys Met Ala 
                405                 410                 415     


Arg Val Phe Ser Val Leu Arg Glu Glu Ser Glu Ser Val Leu Thr Leu 
            420                 425                 430         


Lys Gly Leu Thr Pro Thr Gly Met Leu Pro Ser Gly Val Leu Ala Gly 
        435                 440                 445             


Gly Arg Gln Thr Leu Gln Ser Gly Asn Asp Val Met Gln Leu Ala Val 
    450                 455                 460                 


Pro Gln Met Asp Trp Gly Thr Pro His Ser Phe Ala Asn Asn Ser His 
465                 470                 475                 480 


Asn Ala Cys Arg Glu Phe Leu Leu Phe Phe Ser Ser Cys Leu Ser Ser 
                485                 490                 495     


<210>  2
<211>  41
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(41)
<223>  C-terminal domain only of the human CnAbeta1 aa sequence.

<400>  2

Gly Asn Asp Val Met Gln Leu Ala Val Pro Gln Met Asp Trp Gly Thr 
1               5                   10                  15      


Pro His Ser Phe Ala Asn Asn Ser His Asn Ala Cys Arg Glu Phe Leu 
            20                  25                  30          


Leu Phe Phe Ser Ser Cys Leu Ser Ser 
        35                  40      


<210>  3
<211>  49
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(49)
<223>  Artificial peptide sequence

<400>  3

Gly Gly Arg Gln Thr Leu Gln Ser Gly Asn Asp Val Met Gln Leu Ala 
1               5                   10                  15      


Val Pro Gln Met Asp Trp Gly Thr Pro His Ser Phe Ala Asn Asn Ser 
            20                  25                  30          


His Asn Ala Cys Arg Glu Phe Leu Leu Phe Phe Ser Ser Cys Leu Ser 
        35                  40                  45              


Ser 
    


<210>  4
<211>  77
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(77)
<223>  Artificial sequence

<400>  4

Gly Gly Arg Gln Thr Leu Gln Ser Ala Thr Val Glu Ala Ile Glu Ala 
1               5                   10                  15      


Glu Lys Ala Ile Arg Gly Phe Ser Pro Pro His Arg Ile Cys Ser Phe 
            20                  25                  30          


Glu Glu Ala Lys Gly Leu Asp Arg Ile Asn Glu Arg Met Pro Pro Arg 
        35                  40                  45              


Lys Asp Ala Val Gln Gln Asp Gly Phe Asn Ser Leu Asn Thr Ala His 
    50                  55                  60                  


Ala Thr Glu Asn His Gly Thr Gly Asn His Thr Ala Gln 
65                  70                  75          


