                         SEQUENCE LISTING

<110>  UNIVERSITE DE MONTREAL
       PERREAULT, Claude
       THIBAULT, Pierre
       LEMIEUX, Sebastien
       GRANADOS, Diana Paola
       DEV, Spiranganadane
       DAOUDA, Tariq
       CARON-LIZOTTE, Olivier
 
<120>  METHOD FOR IDENTIFYING NOVEL MINOR HISTOCOMPATIBILITY ANTIGENS

<130>  782/15691.22

<150>  US 61/683,361
<151>  2012-08-15

<150>  US 61/818,040
<151>  2013-05-01

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  10316
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (175)..(9519)

<400>  1
gagaccagaa gcgggcgaat tgggcaccgg tggcggctgc gggcagtttg aattagactc       60

tgggctccag cccgccgaag ccgcgccaga actgtactct ccgagaggtc gttttcccgt      120

ccccgagagc aagtttattt acaaatgttg gagtaataaa gaaggcagaa caaa atg        177
                                                            Met           
                                                            1             

agc tgg gct ttg gaa gaa tgg aaa gaa ggg ctg cct aca aga gct ctt        225
Ser Trp Ala Leu Glu Glu Trp Lys Glu Gly Leu Pro Thr Arg Ala Leu           
            5                   10                  15                    

cag aaa att caa gag ctt gaa gga cag ctt gac aaa ctg aag aag gaa        273
Gln Lys Ile Gln Glu Leu Glu Gly Gln Leu Asp Lys Leu Lys Lys Glu           
        20                  25                  30                        

aag cag caa agg cag ttt cag ctt gac agt ctc gag gct gcg ctg cag        321
Lys Gln Gln Arg Gln Phe Gln Leu Asp Ser Leu Glu Ala Ala Leu Gln           
    35                  40                  45                            

aag caa aaa cag aag gtt gaa aat gaa aaa acc gag ggt aca aac ctg        369
Lys Gln Lys Gln Lys Val Glu Asn Glu Lys Thr Glu Gly Thr Asn Leu           
50                  55                  60                  65            

aaa agg gag aat caa aga ttg atg gaa ata tgt gaa agt ctg gag aaa        417
Lys Arg Glu Asn Gln Arg Leu Met Glu Ile Cys Glu Ser Leu Glu Lys           
                70                  75                  80                

act aag cag aag att tct cat gaa ctt caa gtc aag gag tca caa gtg        465
Thr Lys Gln Lys Ile Ser His Glu Leu Gln Val Lys Glu Ser Gln Val           
            85                  90                  95                    

aat ttc cag gaa gga caa ctg aat tca ggc aaa aaa caa ata gaa aaa        513
Asn Phe Gln Glu Gly Gln Leu Asn Ser Gly Lys Lys Gln Ile Glu Lys           
        100                 105                 110                       

ctg gaa cag gaa ctt aaa agg tgt aaa tct gag ctt gaa aga agc caa        561
Leu Glu Gln Glu Leu Lys Arg Cys Lys Ser Glu Leu Glu Arg Ser Gln           
    115                 120                 125                           

caa gct gcg cag tct gca gat gtc tct ctg aat cca tgc aat aca cca        609
Gln Ala Ala Gln Ser Ala Asp Val Ser Leu Asn Pro Cys Asn Thr Pro           
130                 135                 140                 145           

caa aaa att ttt aca act cca cta aca cca agt caa tat tat agt ggt        657
Gln Lys Ile Phe Thr Thr Pro Leu Thr Pro Ser Gln Tyr Tyr Ser Gly           
                150                 155                 160               

tcc aag tat gaa gat cta aaa gaa aaa tat aat aaa gag gtt gaa gaa        705
Ser Lys Tyr Glu Asp Leu Lys Glu Lys Tyr Asn Lys Glu Val Glu Glu           
            165                 170                 175                   

cga aaa aga tta gag gca gag gtt aaa gcc ttg cag gct aaa aaa gca        753
Arg Lys Arg Leu Glu Ala Glu Val Lys Ala Leu Gln Ala Lys Lys Ala           
        180                 185                 190                       

agc cag act ctt cca caa gcc acc atg aat cac cgc gac att gcc cgg        801
Ser Gln Thr Leu Pro Gln Ala Thr Met Asn His Arg Asp Ile Ala Arg           
    195                 200                 205                           

cat cag gct tca tca tct gtg ttc tca tgg cag caa gag aag acc cca        849
His Gln Ala Ser Ser Ser Val Phe Ser Trp Gln Gln Glu Lys Thr Pro           
210                 215                 220                 225           

agt cat ctt tca tct aat tct caa aga act cca att agg aga gat ttc        897
Ser His Leu Ser Ser Asn Ser Gln Arg Thr Pro Ile Arg Arg Asp Phe           
                230                 235                 240               

tct gca tct tac ttt tct ggg gaa caa gag gtg act cca agt cga tca        945
Ser Ala Ser Tyr Phe Ser Gly Glu Gln Glu Val Thr Pro Ser Arg Ser           
            245                 250                 255                   

act ttg caa ata ggg aaa aga gat gct aat agc agt ttc ttt gac aat        993
Thr Leu Gln Ile Gly Lys Arg Asp Ala Asn Ser Ser Phe Phe Asp Asn           
        260                 265                 270                       

tct agc agt cct cat ctt ttg gat caa tta aaa gcg cag aat caa gag       1041
Ser Ser Ser Pro His Leu Leu Asp Gln Leu Lys Ala Gln Asn Gln Glu           
    275                 280                 285                           

cta aga aac aag att aat gag ttg gaa cta cgc ctg caa gga cat gaa       1089
Leu Arg Asn Lys Ile Asn Glu Leu Glu Leu Arg Leu Gln Gly His Glu           
290                 295                 300                 305           

aaa gaa atg aaa ggc caa gtg aat aag ttt caa gaa ctc caa ctc caa       1137
Lys Glu Met Lys Gly Gln Val Asn Lys Phe Gln Glu Leu Gln Leu Gln           
                310                 315                 320               

ctg gag aaa gca aaa gtg gaa tta att gaa aaa gag aaa gtt ttg aac       1185
Leu Glu Lys Ala Lys Val Glu Leu Ile Glu Lys Glu Lys Val Leu Asn           
            325                 330                 335                   

aaa tgt agg gat gaa cta gtg aga aca aca gca caa tac gac cag gcg       1233
Lys Cys Arg Asp Glu Leu Val Arg Thr Thr Ala Gln Tyr Asp Gln Ala           
        340                 345                 350                       

tca acc aag tat act gca ttg gaa caa aaa ctg aaa aaa ttg acg gaa       1281
Ser Thr Lys Tyr Thr Ala Leu Glu Gln Lys Leu Lys Lys Leu Thr Glu           
    355                 360                 365                           

gat ttg agt tgt cag cga caa aat gca gaa agt gcc aga tgt tct ctg       1329
Asp Leu Ser Cys Gln Arg Gln Asn Ala Glu Ser Ala Arg Cys Ser Leu           
370                 375                 380                 385           

gaa cag aaa att aag gaa aaa gaa aag gag ttt caa gag gag ctc tcc       1377
Glu Gln Lys Ile Lys Glu Lys Glu Lys Glu Phe Gln Glu Glu Leu Ser           
                390                 395                 400               

cgt caa cag cgt tct ttc caa aca ctg gac cag gag tgc atc cag atg       1425
Arg Gln Gln Arg Ser Phe Gln Thr Leu Asp Gln Glu Cys Ile Gln Met           
            405                 410                 415                   

aag gcc aga ctc acc cag gag tta cag caa gcc aag aat atg cac aac       1473
Lys Ala Arg Leu Thr Gln Glu Leu Gln Gln Ala Lys Asn Met His Asn           
        420                 425                 430                       

gtc ctg cag gct gaa ctg gat aaa ctc aca tca gta aag caa cag cta       1521
Val Leu Gln Ala Glu Leu Asp Lys Leu Thr Ser Val Lys Gln Gln Leu           
    435                 440                 445                           

gaa aac aat ttg gaa gag ttt aag caa aag ttg tgc aga gct gaa cag       1569
Glu Asn Asn Leu Glu Glu Phe Lys Gln Lys Leu Cys Arg Ala Glu Gln           
450                 455                 460                 465           

gcg ttc cag gcg agt cag atc aag gag aat gag ctg agg aga agc atg       1617
Ala Phe Gln Ala Ser Gln Ile Lys Glu Asn Glu Leu Arg Arg Ser Met           
                470                 475                 480               

gag gaa atg aag aag gaa aac aac ctc ctt aag agt cac tct gag caa       1665
Glu Glu Met Lys Lys Glu Asn Asn Leu Leu Lys Ser His Ser Glu Gln           
            485                 490                 495                   

aag gcc aga gaa gtc tgc cac ctg gag gca gaa ctc aag aac atc aaa       1713
Lys Ala Arg Glu Val Cys His Leu Glu Ala Glu Leu Lys Asn Ile Lys           
        500                 505                 510                       

cag tgt tta aat cag agc cag aat ttt gca gaa gaa atg aaa gcg aag       1761
Gln Cys Leu Asn Gln Ser Gln Asn Phe Ala Glu Glu Met Lys Ala Lys           
    515                 520                 525                           

aat acc tct cag gaa acc atg tta aga gat ctt caa gaa aaa ata aat       1809
Asn Thr Ser Gln Glu Thr Met Leu Arg Asp Leu Gln Glu Lys Ile Asn           
530                 535                 540                 545           

cag caa gaa aac tcc ttg act tta gaa aaa ctg aag ctt gct gtg gct       1857
Gln Gln Glu Asn Ser Leu Thr Leu Glu Lys Leu Lys Leu Ala Val Ala           
                550                 555                 560               

gat ctg gaa aag cag cga gat tgt tct caa gac ctt ttg aag aaa aga       1905
Asp Leu Glu Lys Gln Arg Asp Cys Ser Gln Asp Leu Leu Lys Lys Arg           
            565                 570                 575                   

gaa cat cac att gaa caa ctt aat gat aag tta agc aag aca gag aaa       1953
Glu His His Ile Glu Gln Leu Asn Asp Lys Leu Ser Lys Thr Glu Lys           
        580                 585                 590                       

gag tcc aaa gcc ttg ctg agt gct tta gag tta aaa aag aaa gaa tat       2001
Glu Ser Lys Ala Leu Leu Ser Ala Leu Glu Leu Lys Lys Lys Glu Tyr           
    595                 600                 605                           

gaa gaa ttg aaa gaa gag aaa act ctg ttt tct tgt tgg aaa agt gaa       2049
Glu Glu Leu Lys Glu Glu Lys Thr Leu Phe Ser Cys Trp Lys Ser Glu           
610                 615                 620                 625           

aac gaa aaa ctt tta act cag atg gaa tca gaa aag gaa aac ttg cag       2097
Asn Glu Lys Leu Leu Thr Gln Met Glu Ser Glu Lys Glu Asn Leu Gln           
                630                 635                 640               

agt aaa att aat cac ttg gaa act tgt ctg aag aca cag caa ata aaa       2145
Ser Lys Ile Asn His Leu Glu Thr Cys Leu Lys Thr Gln Gln Ile Lys           
            645                 650                 655                   

agt cat gaa tac aac gag aga gta aga acg ctg gag atg gac aga gaa       2193
Ser His Glu Tyr Asn Glu Arg Val Arg Thr Leu Glu Met Asp Arg Glu           
        660                 665                 670                       

aac cta agt gtc gag atc aga aac ctt cac aac gtg tta gac agt aag       2241
Asn Leu Ser Val Glu Ile Arg Asn Leu His Asn Val Leu Asp Ser Lys           
    675                 680                 685                           

tca gtg gag gta gag acc cag aaa cta gct tat atg gag cta cag cag       2289
Ser Val Glu Val Glu Thr Gln Lys Leu Ala Tyr Met Glu Leu Gln Gln           
690                 695                 700                 705           

aaa gct gag ttc tca gat cag aaa cat cag aag gaa ata gaa aat atg       2337
Lys Ala Glu Phe Ser Asp Gln Lys His Gln Lys Glu Ile Glu Asn Met           
                710                 715                 720               

tgt ttg aag act tct cag ctt act ggg caa gtt gaa gat cta gaa cac       2385
Cys Leu Lys Thr Ser Gln Leu Thr Gly Gln Val Glu Asp Leu Glu His           
            725                 730                 735                   

aag ctt cag tta ctg tca aat gaa ata atg gac aaa gac cgg tgt tac       2433
Lys Leu Gln Leu Leu Ser Asn Glu Ile Met Asp Lys Asp Arg Cys Tyr           
        740                 745                 750                       

caa gac ttg cat gcc gaa tat gag agc ctc agg gat ctg cta aaa tcc       2481
Gln Asp Leu His Ala Glu Tyr Glu Ser Leu Arg Asp Leu Leu Lys Ser           
    755                 760                 765                           

aaa gat gct tct ctg gtg aca aat gaa gat cat cag aga agt ctt ttg       2529
Lys Asp Ala Ser Leu Val Thr Asn Glu Asp His Gln Arg Ser Leu Leu           
770                 775                 780                 785           

gct ttt gat cag cag cct gcc atg cat cat tcc ttt gca aat ata att       2577
Ala Phe Asp Gln Gln Pro Ala Met His His Ser Phe Ala Asn Ile Ile           
                790                 795                 800               

gga gaa caa gga agc atg cct tca gag agg agt gaa tgt cgt tta gaa       2625
Gly Glu Gln Gly Ser Met Pro Ser Glu Arg Ser Glu Cys Arg Leu Glu           
            805                 810                 815                   

gca gac caa agt ccg aaa aat tct gcc atc cta caa aat aga gtt gat       2673
Ala Asp Gln Ser Pro Lys Asn Ser Ala Ile Leu Gln Asn Arg Val Asp           
        820                 825                 830                       

tca ctt gaa ttt tca tta gag tct caa aaa cag atg aac tca gac ctg       2721
Ser Leu Glu Phe Ser Leu Glu Ser Gln Lys Gln Met Asn Ser Asp Leu           
    835                 840                 845                           

caa aag cag tgt gaa gag ttg gtg caa atc aaa gga gaa ata gaa gaa       2769
Gln Lys Gln Cys Glu Glu Leu Val Gln Ile Lys Gly Glu Ile Glu Glu           
850                 855                 860                 865           

aat ctc atg aaa gca gaa cag atg cat caa agt ttt gtg gct gaa aca       2817
Asn Leu Met Lys Ala Glu Gln Met His Gln Ser Phe Val Ala Glu Thr           
                870                 875                 880               

agt cag cgc att agt aag tta cag gaa gac act tct gct cac cag aat       2865
Ser Gln Arg Ile Ser Lys Leu Gln Glu Asp Thr Ser Ala His Gln Asn           
            885                 890                 895                   

gtt gtt gct gaa acc tta agt gcc ctt gag aac aag gaa aaa gag ctg       2913
Val Val Ala Glu Thr Leu Ser Ala Leu Glu Asn Lys Glu Lys Glu Leu           
        900                 905                 910                       

caa ctt tta aat gat aag gta gaa act gag cag gca gag att caa gaa       2961
Gln Leu Leu Asn Asp Lys Val Glu Thr Glu Gln Ala Glu Ile Gln Glu           
    915                 920                 925                           

tta aaa aag agc aac cat cta ctt gaa gac tct cta aag gag cta caa       3009
Leu Lys Lys Ser Asn His Leu Leu Glu Asp Ser Leu Lys Glu Leu Gln           
930                 935                 940                 945           

ctt tta tcc gaa acc cta agc ttg gag aag aaa gaa atg agt tcc atc       3057
Leu Leu Ser Glu Thr Leu Ser Leu Glu Lys Lys Glu Met Ser Ser Ile           
                950                 955                 960               

att tct cta aat aaa agg gaa att gaa gag ctg acc caa gag aat ggg       3105
Ile Ser Leu Asn Lys Arg Glu Ile Glu Glu Leu Thr Gln Glu Asn Gly           
            965                 970                 975                   

act ctt aag gaa att aat gca tcc tta aat caa gag aag atg aac tta       3153
Thr Leu Lys Glu Ile Asn Ala Ser Leu Asn Gln Glu Lys Met Asn Leu           
        980                 985                 990                       

atc cag aaa agt gag agt ttt  gca aac tat ata gat  gaa agg gag aaa     3201
Ile Gln Lys Ser Glu Ser Phe  Ala Asn Tyr Ile Asp  Glu Arg Glu Lys         
    995                 1000                 1005                         

agc  att tca gag tta tct  gat cag tac aag caa  gaa aaa ctt att        3246
Ser  Ile Ser Glu Leu Ser  Asp Gln Tyr Lys Gln  Glu Lys Leu Ile            
1010                 1015                 1020                            

tta  cta caa aga tgt gaa  gaa acc gga aat gca  tat gag gat ctt        3291
Leu  Leu Gln Arg Cys Glu  Glu Thr Gly Asn Ala  Tyr Glu Asp Leu            
1025                 1030                 1035                            

agt  caa aaa tac aaa gca  gca cag gaa aag aat  tct aaa tta gaa        3336
Ser  Gln Lys Tyr Lys Ala  Ala Gln Glu Lys Asn  Ser Lys Leu Glu            
1040                 1045                 1050                            

tgc  ttg cta aat gaa tgc  act agt ctt tgt gaa  aat agg aaa aat        3381
Cys  Leu Leu Asn Glu Cys  Thr Ser Leu Cys Glu  Asn Arg Lys Asn            
1055                 1060                 1065                            

gag  ttg gaa cag cta aag  gaa gca ttt gca aag  gaa cac caa gaa        3426
Glu  Leu Glu Gln Leu Lys  Glu Ala Phe Ala Lys  Glu His Gln Glu            
1070                 1075                 1080                            

ttc  tta aca aaa tta gca  ttt gct gaa gaa aga  aat cag aat ctg        3471
Phe  Leu Thr Lys Leu Ala  Phe Ala Glu Glu Arg  Asn Gln Asn Leu            
1085                 1090                 1095                            

atg  cta gag ttg gag aca  gtg cag caa gct ctg  aga tct gag atg        3516
Met  Leu Glu Leu Glu Thr  Val Gln Gln Ala Leu  Arg Ser Glu Met            
1100                 1105                 1110                            

aca  gat aac caa aac aat  tct aag agc gag gct  ggt ggt tta aag        3561
Thr  Asp Asn Gln Asn Asn  Ser Lys Ser Glu Ala  Gly Gly Leu Lys            
1115                 1120                 1125                            

caa  gaa atc atg act tta  aag gaa gaa caa aac  aaa atg caa aag        3606
Gln  Glu Ile Met Thr Leu  Lys Glu Glu Gln Asn  Lys Met Gln Lys            
1130                 1135                 1140                            

gaa  gtt aat gac tta tta  caa gag aat gaa cag  ctg atg aag gta        3651
Glu  Val Asn Asp Leu Leu  Gln Glu Asn Glu Gln  Leu Met Lys Val            
1145                 1150                 1155                            

atg  aag act aaa cat gaa  tgt caa aat cta gaa  tca gaa cca att        3696
Met  Lys Thr Lys His Glu  Cys Gln Asn Leu Glu  Ser Glu Pro Ile            
1160                 1165                 1170                            

agg  aac tct gtg aaa gaa  aga gag agt gag aga  aat caa tgt aat        3741
Arg  Asn Ser Val Lys Glu  Arg Glu Ser Glu Arg  Asn Gln Cys Asn            
1175                 1180                 1185                            

ttt  aaa cct cag atg gat  ctt gaa gtt aaa gaa  att tct cta gat        3786
Phe  Lys Pro Gln Met Asp  Leu Glu Val Lys Glu  Ile Ser Leu Asp            
1190                 1195                 1200                            

agt  tat aat gcg cag ttg  gtg caa tta gaa gct  atg cta aga aat        3831
Ser  Tyr Asn Ala Gln Leu  Val Gln Leu Glu Ala  Met Leu Arg Asn            
1205                 1210                 1215                            

aag  gaa tta aaa ctt cag  gaa agt gag aag gag  aag gag tgc ctg        3876
Lys  Glu Leu Lys Leu Gln  Glu Ser Glu Lys Glu  Lys Glu Cys Leu            
1220                 1225                 1230                            

cag  cat gaa tta cag aca  att aga gga gat ctt  gaa acc agc aat        3921
Gln  His Glu Leu Gln Thr  Ile Arg Gly Asp Leu  Glu Thr Ser Asn            
1235                 1240                 1245                            

ttg  caa gac atg cag tca  caa gaa att agt ggc  ctt aaa gac tgt        3966
Leu  Gln Asp Met Gln Ser  Gln Glu Ile Ser Gly  Leu Lys Asp Cys            
1250                 1255                 1260                            

gaa  ata gat gcg gaa gaa  aag tat att tca ggg  cct cat gag ttg        4011
Glu  Ile Asp Ala Glu Glu  Lys Tyr Ile Ser Gly  Pro His Glu Leu            
1265                 1270                 1275                            

tca  aca agt caa aac gac  aat gca cac ctt cag  tgc tct ctg caa        4056
Ser  Thr Ser Gln Asn Asp  Asn Ala His Leu Gln  Cys Ser Leu Gln            
1280                 1285                 1290                            

aca  aca atg aac aag ctg  aat gag cta gag aaa  ata tgt gaa ata        4101
Thr  Thr Met Asn Lys Leu  Asn Glu Leu Glu Lys  Ile Cys Glu Ile            
1295                 1300                 1305                            

ctg  cag gct gaa aag tat  gaa ctc gta act gag  ctg aat gat tca        4146
Leu  Gln Ala Glu Lys Tyr  Glu Leu Val Thr Glu  Leu Asn Asp Ser            
1310                 1315                 1320                            

agg  tca gaa tgt atc aca  gca act agg aaa atg  gca gaa gag gta        4191
Arg  Ser Glu Cys Ile Thr  Ala Thr Arg Lys Met  Ala Glu Glu Val            
1325                 1330                 1335                            

ggg  aaa cta cta aat gaa  gtt aaa ata tta aat  gat gac agt ggt        4236
Gly  Lys Leu Leu Asn Glu  Val Lys Ile Leu Asn  Asp Asp Ser Gly            
1340                 1345                 1350                            

ctt  ctc cat ggt gag tta  gtg gaa gac ata cca  gga ggt gaa ttt        4281
Leu  Leu His Gly Glu Leu  Val Glu Asp Ile Pro  Gly Gly Glu Phe            
1355                 1360                 1365                            

ggt  gaa caa cca aat gaa  cag cac cct gtg tct  ttg gct cca ttg        4326
Gly  Glu Gln Pro Asn Glu  Gln His Pro Val Ser  Leu Ala Pro Leu            
1370                 1375                 1380                            

gac  gag agt aat tcc tac  gag cac ttg aca ttg  tca gac aaa gaa        4371
Asp  Glu Ser Asn Ser Tyr  Glu His Leu Thr Leu  Ser Asp Lys Glu            
1385                 1390                 1395                            

gtt  caa atg cac ttt gcc  gaa ttg caa gag aaa  ttc tta tct tta        4416
Val  Gln Met His Phe Ala  Glu Leu Gln Glu Lys  Phe Leu Ser Leu            
1400                 1405                 1410                            

caa  agt gaa cac aaa att  tta cat gat cag cac  tgt cag atg agc        4461
Gln  Ser Glu His Lys Ile  Leu His Asp Gln His  Cys Gln Met Ser            
1415                 1420                 1425                            

tct  aaa atg tca gag ctg  cag acc tat gtt gac  tca tta aag gcc        4506
Ser  Lys Met Ser Glu Leu  Gln Thr Tyr Val Asp  Ser Leu Lys Ala            
1430                 1435                 1440                            

gaa  aat ttg gtc ttg tca  acg aat ctg aga aac  ttt caa ggt gac        4551
Glu  Asn Leu Val Leu Ser  Thr Asn Leu Arg Asn  Phe Gln Gly Asp            
1445                 1450                 1455                            

ttg  gtg aag gag atg cag  ctg ggc ttg gag gag  ggg ctc gtt cca        4596
Leu  Val Lys Glu Met Gln  Leu Gly Leu Glu Glu  Gly Leu Val Pro            
1460                 1465                 1470                            

tcc  ctg tca tcc tct tgt  gtg cct gac agc tct  agt ctt agc agt        4641
Ser  Leu Ser Ser Ser Cys  Val Pro Asp Ser Ser  Ser Leu Ser Ser            
1475                 1480                 1485                            

ttg  gga gac tcc tcc ttt  tac aga gct ctt tta  gaa cag aca gga        4686
Leu  Gly Asp Ser Ser Phe  Tyr Arg Ala Leu Leu  Glu Gln Thr Gly            
1490                 1495                 1500                            

gat  atg tct ctt ttg agt  aat tta gaa ggg gct  gtt tca gca aac        4731
Asp  Met Ser Leu Leu Ser  Asn Leu Glu Gly Ala  Val Ser Ala Asn            
1505                 1510                 1515                            

cag  tgc agt gta gat gaa  gta ttt tgc agc agt  ctg cag gag gag        4776
Gln  Cys Ser Val Asp Glu  Val Phe Cys Ser Ser  Leu Gln Glu Glu            
1520                 1525                 1530                            

aat  ctg acc agg aaa gaa  acc cct tcg gcc cca  gcg aag ggt gtt        4821
Asn  Leu Thr Arg Lys Glu  Thr Pro Ser Ala Pro  Ala Lys Gly Val            
1535                 1540                 1545                            

gaa  gag ctt gag tcc ctc  tgt gag gtg tac cgg  cag tcc ctc gag        4866
Glu  Glu Leu Glu Ser Leu  Cys Glu Val Tyr Arg  Gln Ser Leu Glu            
1550                 1555                 1560                            

aag  cta gaa gag aaa atg  gaa agt caa ggg att  atg aaa aat aag        4911
Lys  Leu Glu Glu Lys Met  Glu Ser Gln Gly Ile  Met Lys Asn Lys            
1565                 1570                 1575                            

gaa  att caa gag ctc gag  cag tta tta agt tct  gaa agg caa gag        4956
Glu  Ile Gln Glu Leu Glu  Gln Leu Leu Ser Ser  Glu Arg Gln Glu            
1580                 1585                 1590                            

ctt  gac tgc ctt agg aag  cag tat ttg tca gaa  aat gaa cag tgg        5001
Leu  Asp Cys Leu Arg Lys  Gln Tyr Leu Ser Glu  Asn Glu Gln Trp            
1595                 1600                 1605                            

caa  cag aag ctg aca agc  gtg act ctg gag atg  gag tcc aag ttg        5046
Gln  Gln Lys Leu Thr Ser  Val Thr Leu Glu Met  Glu Ser Lys Leu            
1610                 1615                 1620                            

gcg  gca gaa aag aaa cag  acg gaa caa ctg tca  ctt gag ctg gaa        5091
Ala  Ala Glu Lys Lys Gln  Thr Glu Gln Leu Ser  Leu Glu Leu Glu            
1625                 1630                 1635                            

gta  gca cga ctc cag cta  caa ggt ctg gac tta  agt tct cgg tct        5136
Val  Ala Arg Leu Gln Leu  Gln Gly Leu Asp Leu  Ser Ser Arg Ser            
1640                 1645                 1650                            

ttg  ctt ggc atc gac aca  gaa gat gct att caa  ggc cga aat gag        5181
Leu  Leu Gly Ile Asp Thr  Glu Asp Ala Ile Gln  Gly Arg Asn Glu            
1655                 1660                 1665                            

agc  tgt gac ata tca aaa  gaa cat act tca gaa  act aca gaa aga        5226
Ser  Cys Asp Ile Ser Lys  Glu His Thr Ser Glu  Thr Thr Glu Arg            
1670                 1675                 1680                            

aca  cca aag cat gat gtt  cat cag att tgt gat  aaa gat gct cag        5271
Thr  Pro Lys His Asp Val  His Gln Ile Cys Asp  Lys Asp Ala Gln            
1685                 1690                 1695                            

cag  gac ctc aat cta gac  att gag aaa ata act  gag act ggt gca        5316
Gln  Asp Leu Asn Leu Asp  Ile Glu Lys Ile Thr  Glu Thr Gly Ala            
1700                 1705                 1710                            

gtg  aaa ccc aca gga gag  tgc tct ggg gaa cag  tcc cca gat acc        5361
Val  Lys Pro Thr Gly Glu  Cys Ser Gly Glu Gln  Ser Pro Asp Thr            
1715                 1720                 1725                            

aat  tat gag cct cca ggg  gaa gat aaa acc cag  ggc tct tca gaa        5406
Asn  Tyr Glu Pro Pro Gly  Glu Asp Lys Thr Gln  Gly Ser Ser Glu            
1730                 1735                 1740                            

tgc  att tct gaa ttg tca  ttt tct ggt cct aat  gct ttg gta cct        5451
Cys  Ile Ser Glu Leu Ser  Phe Ser Gly Pro Asn  Ala Leu Val Pro            
1745                 1750                 1755                            

atg  gat ttc ctg ggg aat  cag gaa gat atc cat  aat ctt caa ctg        5496
Met  Asp Phe Leu Gly Asn  Gln Glu Asp Ile His  Asn Leu Gln Leu            
1760                 1765                 1770                            

cgg  gta aaa gag aca tca  aat gag aat ttg aga  tta ctt cat gtg        5541
Arg  Val Lys Glu Thr Ser  Asn Glu Asn Leu Arg  Leu Leu His Val            
1775                 1780                 1785                            

ata  gag gac cgt gac aga  aaa gtt gaa agt ttg  cta aat gaa atg        5586
Ile  Glu Asp Arg Asp Arg  Lys Val Glu Ser Leu  Leu Asn Glu Met            
1790                 1795                 1800                            

aaa  gaa tta gac tca aaa  ctc cat tta cag gag  gta caa cta atg        5631
Lys  Glu Leu Asp Ser Lys  Leu His Leu Gln Glu  Val Gln Leu Met            
1805                 1810                 1815                            

acc  aaa att gaa gca tgc  ata gaa ttg gaa aaa  ata gtt ggg gaa        5676
Thr  Lys Ile Glu Ala Cys  Ile Glu Leu Glu Lys  Ile Val Gly Glu            
1820                 1825                 1830                            

ctt  aag aaa gaa aac tca  gat tta agt gaa aaa  ttg gaa tat ttt        5721
Leu  Lys Lys Glu Asn Ser  Asp Leu Ser Glu Lys  Leu Glu Tyr Phe            
1835                 1840                 1845                            

tct  tgt gat cac cag gag  tta ctc cag aga gta  gaa act tct gaa        5766
Ser  Cys Asp His Gln Glu  Leu Leu Gln Arg Val  Glu Thr Ser Glu            
1850                 1855                 1860                            

ggc  ctc aat tct gat tta  gaa atg cat gca gat  aaa tca tca cgt        5811
Gly  Leu Asn Ser Asp Leu  Glu Met His Ala Asp  Lys Ser Ser Arg            
1865                 1870                 1875                            

gaa  gat att gga gat aat  gtg gcc aag gtg aat  gac agc tgg aag        5856
Glu  Asp Ile Gly Asp Asn  Val Ala Lys Val Asn  Asp Ser Trp Lys            
1880                 1885                 1890                            

gag  aga ttt ctt gat gtg  gaa aat gag ctg agt  agg atc aga tcg        5901
Glu  Arg Phe Leu Asp Val  Glu Asn Glu Leu Ser  Arg Ile Arg Ser            
1895                 1900                 1905                            

gag  aaa gct agc att gag  cat gaa gcc ctc tac  ctg gag gct gac        5946
Glu  Lys Ala Ser Ile Glu  His Glu Ala Leu Tyr  Leu Glu Ala Asp            
1910                 1915                 1920                            

tta  gag gta gtt caa aca  gag aag cta tgt tta  gaa aaa gac aat        5991
Leu  Glu Val Val Gln Thr  Glu Lys Leu Cys Leu  Glu Lys Asp Asn            
1925                 1930                 1935                            

gaa  aat aag cag aag gtt  att gtc tgc ctt gaa  gaa gaa ctc tca        6036
Glu  Asn Lys Gln Lys Val  Ile Val Cys Leu Glu  Glu Glu Leu Ser            
1940                 1945                 1950                            

gtg  gtc aca agt gag aga  aac cag ctt cgt gga  gaa tta gat act        6081
Val  Val Thr Ser Glu Arg  Asn Gln Leu Arg Gly  Glu Leu Asp Thr            
1955                 1960                 1965                            

atg  tca aaa aaa acc acg  gca ctg gat cag ttg  tct gaa aaa atg        6126
Met  Ser Lys Lys Thr Thr  Ala Leu Asp Gln Leu  Ser Glu Lys Met            
1970                 1975                 1980                            

aag  gag aaa aca caa gag  ctt gag tct cat caa  agt gag tgt ctc        6171
Lys  Glu Lys Thr Gln Glu  Leu Glu Ser His Gln  Ser Glu Cys Leu            
1985                 1990                 1995                            

cat  tgc att cag gtg gca  gag gca gag gtg aag  gaa aag acg gaa        6216
His  Cys Ile Gln Val Ala  Glu Ala Glu Val Lys  Glu Lys Thr Glu            
2000                 2005                 2010                            

ctc  ctt cag act ttg tcc  tct gat gtg agt gag  ctg tta aaa gac        6261
Leu  Leu Gln Thr Leu Ser  Ser Asp Val Ser Glu  Leu Leu Lys Asp            
2015                 2020                 2025                            

aaa  act cat ctc cag gaa  aag ctg cag agt ttg  gaa aag gac tca        6306
Lys  Thr His Leu Gln Glu  Lys Leu Gln Ser Leu  Glu Lys Asp Ser            
2030                 2035                 2040                            

cag  gca ctg tct ttg aca  aaa tgt gag ctg gaa  aac caa att gca        6351
Gln  Ala Leu Ser Leu Thr  Lys Cys Glu Leu Glu  Asn Gln Ile Ala            
2045                 2050                 2055                            

caa  ctg aat aaa gag aaa  gaa ttg ctt gtc aag  gaa tct gaa agc        6396
Gln  Leu Asn Lys Glu Lys  Glu Leu Leu Val Lys  Glu Ser Glu Ser            
2060                 2065                 2070                            

ctg  cag gcc aga ctg agt  gaa tca gat tat gaa  aag ctg aat gtc        6441
Leu  Gln Ala Arg Leu Ser  Glu Ser Asp Tyr Glu  Lys Leu Asn Val            
2075                 2080                 2085                            

tcc  aag gcc ttg gag gcc  gca ctg gtg gag aaa  ggt gag ttc gca        6486
Ser  Lys Ala Leu Glu Ala  Ala Leu Val Glu Lys  Gly Glu Phe Ala            
2090                 2095                 2100                            

ttg  agg ctg agc tca aca  cag gag gaa gtg cat  cag ctg aga aga        6531
Leu  Arg Leu Ser Ser Thr  Gln Glu Glu Val His  Gln Leu Arg Arg            
2105                 2110                 2115                            

ggc  atc gag aaa ctg aga  gtt cgc att gag gcc  gat gaa aag aag        6576
Gly  Ile Glu Lys Leu Arg  Val Arg Ile Glu Ala  Asp Glu Lys Lys            
2120                 2125                 2130                            

cag  ctg cac atc gca gag  aaa ctg aaa gaa cgc  gag cgg gag aat        6621
Gln  Leu His Ile Ala Glu  Lys Leu Lys Glu Arg  Glu Arg Glu Asn            
2135                 2140                 2145                            

gat  tca ctt aag gat aaa  gtt gag aac ctt gaa  agg gaa ttg cag        6666
Asp  Ser Leu Lys Asp Lys  Val Glu Asn Leu Glu  Arg Glu Leu Gln            
2150                 2155                 2160                            

atg  tca gaa gaa aac cag  gag cta gtg att ctt  gat gcc gag aat        6711
Met  Ser Glu Glu Asn Gln  Glu Leu Val Ile Leu  Asp Ala Glu Asn            
2165                 2170                 2175                            

tcc  aaa gca gaa gta gag  act cta aaa aca caa  ata gaa gag atg        6756
Ser  Lys Ala Glu Val Glu  Thr Leu Lys Thr Gln  Ile Glu Glu Met            
2180                 2185                 2190                            

gcc  aga agc ctg aaa gtt  ttt gaa tta gac ctt  gtc acg tta agg        6801
Ala  Arg Ser Leu Lys Val  Phe Glu Leu Asp Leu  Val Thr Leu Arg            
2195                 2200                 2205                            

tct  gaa aaa gaa aat ctg  aca aaa caa ata caa  gaa aaa caa ggt        6846
Ser  Glu Lys Glu Asn Leu  Thr Lys Gln Ile Gln  Glu Lys Gln Gly            
2210                 2215                 2220                            

cag  ttg tca gaa cta gac  aag tta ctc tct tca  ttt aaa agt ctg        6891
Gln  Leu Ser Glu Leu Asp  Lys Leu Leu Ser Ser  Phe Lys Ser Leu            
2225                 2230                 2235                            

tta  gaa gaa aag gag caa  gca gag ata cag atc  aaa gaa gaa tct        6936
Leu  Glu Glu Lys Glu Gln  Ala Glu Ile Gln Ile  Lys Glu Glu Ser            
2240                 2245                 2250                            

aaa  act gca gtg gag atg  ctt cag aat cag tta  aag gag cta aat        6981
Lys  Thr Ala Val Glu Met  Leu Gln Asn Gln Leu  Lys Glu Leu Asn            
2255                 2260                 2265                            

gag  gca gta gca gcc ttg  tgt ggt gac caa gaa  att atg aag gcc        7026
Glu  Ala Val Ala Ala Leu  Cys Gly Asp Gln Glu  Ile Met Lys Ala            
2270                 2275                 2280                            

aca  gaa cag agt cta gac  cca cca ata gag gaa  gag cat cag ctg        7071
Thr  Glu Gln Ser Leu Asp  Pro Pro Ile Glu Glu  Glu His Gln Leu            
2285                 2290                 2295                            

aga  aat agc att gaa aag  ctg aga gcc cgc cta  gaa gct gat gaa        7116
Arg  Asn Ser Ile Glu Lys  Leu Arg Ala Arg Leu  Glu Ala Asp Glu            
2300                 2305                 2310                            

aag  aag cag ctc tgt gtc  tta caa caa ctg aag  gaa agt gag cat        7161
Lys  Lys Gln Leu Cys Val  Leu Gln Gln Leu Lys  Glu Ser Glu His            
2315                 2320                 2325                            

cat  gca gat tta ctt aag  ggt aga gtg gag aac  ctt gaa aga gag        7206
His  Ala Asp Leu Leu Lys  Gly Arg Val Glu Asn  Leu Glu Arg Glu            
2330                 2335                 2340                            

cta  gag ata gcc agg aca  aac caa gag cat gca  gct ctt gag gca        7251
Leu  Glu Ile Ala Arg Thr  Asn Gln Glu His Ala  Ala Leu Glu Ala            
2345                 2350                 2355                            

gag  aat tcc aaa gga gag  gta gag acc cta aaa  gca aaa ata gaa        7296
Glu  Asn Ser Lys Gly Glu  Val Glu Thr Leu Lys  Ala Lys Ile Glu            
2360                 2365                 2370                            

ggg  atg acc caa agt ctg  aga ggt ctg gaa tta  gat gtt gtt act        7341
Gly  Met Thr Gln Ser Leu  Arg Gly Leu Glu Leu  Asp Val Val Thr            
2375                 2380                 2385                            

ata  agg tca gaa aaa gaa  aat ctg aca aat gaa  tta caa aaa gag        7386
Ile  Arg Ser Glu Lys Glu  Asn Leu Thr Asn Glu  Leu Gln Lys Glu            
2390                 2395                 2400                            

caa  gag cga ata tct gaa  tta gaa ata ata aat  tca tca ttt gaa        7431
Gln  Glu Arg Ile Ser Glu  Leu Glu Ile Ile Asn  Ser Ser Phe Glu            
2405                 2410                 2415                            

aat  att ttg caa gaa aaa  gag caa gag aaa gta  cag atg aaa gaa        7476
Asn  Ile Leu Gln Glu Lys  Glu Gln Glu Lys Val  Gln Met Lys Glu            
2420                 2425                 2430                            

aaa  tca agc act gcc atg  gag atg ctt caa aca  caa tta aaa gag        7521
Lys  Ser Ser Thr Ala Met  Glu Met Leu Gln Thr  Gln Leu Lys Glu            
2435                 2440                 2445                            

ctc  aat gag aga gtg gca  gcc ctg cat aat gac  caa gaa gcc tgt        7566
Leu  Asn Glu Arg Val Ala  Ala Leu His Asn Asp  Gln Glu Ala Cys            
2450                 2455                 2460                            

aag  gcc aaa gag cag aat  ctt agt agt caa gta  gag tgt ctt gaa        7611
Lys  Ala Lys Glu Gln Asn  Leu Ser Ser Gln Val  Glu Cys Leu Glu            
2465                 2470                 2475                            

ctt  gag aag gct cag ttg  cta caa ggc ctt gat  gag gcc aaa aat        7656
Leu  Glu Lys Ala Gln Leu  Leu Gln Gly Leu Asp  Glu Ala Lys Asn            
2480                 2485                 2490                            

aat  tat att gtt ttg caa  tct tca gtg aat ggc  ctc att caa gaa        7701
Asn  Tyr Ile Val Leu Gln  Ser Ser Val Asn Gly  Leu Ile Gln Glu            
2495                 2500                 2505                            

gta  gaa gat ggc aag cag  aaa ctg gag aag aag  gat gaa gaa atc        7746
Val  Glu Asp Gly Lys Gln  Lys Leu Glu Lys Lys  Asp Glu Glu Ile            
2510                 2515                 2520                            

agt  aga ctg aaa aat caa  att caa gac caa gag  cag ctt gtc tct        7791
Ser  Arg Leu Lys Asn Gln  Ile Gln Asp Gln Glu  Gln Leu Val Ser            
2525                 2530                 2535                            

aaa  ctg tcc cag gtg gaa  gga gag cac caa ctt  tgg aag gag caa        7836
Lys  Leu Ser Gln Val Glu  Gly Glu His Gln Leu  Trp Lys Glu Gln            
2540                 2545                 2550                            

aac  tta gaa ctg aga aat  ctg aca gtg gaa ttg  gag cag aag atc        7881
Asn  Leu Glu Leu Arg Asn  Leu Thr Val Glu Leu  Glu Gln Lys Ile            
2555                 2560                 2565                            

caa  gtg cta caa tcc aaa  aat gcc tct ttg cag  gac aca tta gaa        7926
Gln  Val Leu Gln Ser Lys  Asn Ala Ser Leu Gln  Asp Thr Leu Glu            
2570                 2575                 2580                            

gtg  ctg cag agt tct tac  aag aat cta gag aat  gag ctt gaa ttg        7971
Val  Leu Gln Ser Ser Tyr  Lys Asn Leu Glu Asn  Glu Leu Glu Leu            
2585                 2590                 2595                            

aca  aaa atg gac aaa atg  tcc ttt gtt gaa aaa  gta aac aaa atg        8016
Thr  Lys Met Asp Lys Met  Ser Phe Val Glu Lys  Val Asn Lys Met            
2600                 2605                 2610                            

act  gca aag gaa act gag  ctg cag agg gaa atg  cat gag atg gca        8061
Thr  Ala Lys Glu Thr Glu  Leu Gln Arg Glu Met  His Glu Met Ala            
2615                 2620                 2625                            

cag  aaa aca gca gag ctg  caa gaa gaa ctc agt  gga gag aaa aat        8106
Gln  Lys Thr Ala Glu Leu  Gln Glu Glu Leu Ser  Gly Glu Lys Asn            
2630                 2635                 2640                            

agg  cta gct gga gag ttg  cag tta ctg ttg gaa  gaa ata aag agc        8151
Arg  Leu Ala Gly Glu Leu  Gln Leu Leu Leu Glu  Glu Ile Lys Ser            
2645                 2650                 2655                            

agc  aaa gat caa ttg aag  gag ctc aca cta gaa  aat agt gaa ttg        8196
Ser  Lys Asp Gln Leu Lys  Glu Leu Thr Leu Glu  Asn Ser Glu Leu            
2660                 2665                 2670                            

aag  aag agc cta gat tgc  atg cac aaa gac cag  gtg gaa aag gaa        8241
Lys  Lys Ser Leu Asp Cys  Met His Lys Asp Gln  Val Glu Lys Glu            
2675                 2680                 2685                            

ggg  aaa gtg aga gag gaa  ata gct gaa tat cag  cta cgg ctt cat        8286
Gly  Lys Val Arg Glu Glu  Ile Ala Glu Tyr Gln  Leu Arg Leu His            
2690                 2695                 2700                            

gaa  gct gaa aag aaa cac  cag gct ttg ctt ttg  gac aca aac aaa        8331
Glu  Ala Glu Lys Lys His  Gln Ala Leu Leu Leu  Asp Thr Asn Lys            
2705                 2710                 2715                            

cag  tat gaa gta gaa atc  cag aca tac cga gag  aaa ttg act tct        8376
Gln  Tyr Glu Val Glu Ile  Gln Thr Tyr Arg Glu  Lys Leu Thr Ser            
2720                 2725                 2730                            

aaa  gaa gaa tgt ctc agt  tca cag aag ctg gag  ata gac ctt tta        8421
Lys  Glu Glu Cys Leu Ser  Ser Gln Lys Leu Glu  Ile Asp Leu Leu            
2735                 2740                 2745                            

aag  tct agt aaa gaa gag  ctc aat aat tca ttg  aaa gct act act        8466
Lys  Ser Ser Lys Glu Glu  Leu Asn Asn Ser Leu  Lys Ala Thr Thr            
2750                 2755                 2760                            

cag  att ttg gaa gaa ttg  aag aaa acc aag atg  gac aat cta aaa        8511
Gln  Ile Leu Glu Glu Leu  Lys Lys Thr Lys Met  Asp Asn Leu Lys            
2765                 2770                 2775                            

tat  gta aat cag ttg aag  aag gaa aat gaa cgt  gcc cag ggg aaa        8556
Tyr  Val Asn Gln Leu Lys  Lys Glu Asn Glu Arg  Ala Gln Gly Lys            
2780                 2785                 2790                            

atg  aag ttg ttg atc aaa  tcc tgt aaa cag ctg  gaa gag gaa aag        8601
Met  Lys Leu Leu Ile Lys  Ser Cys Lys Gln Leu  Glu Glu Glu Lys            
2795                 2800                 2805                            

gag  ata ctg cag aaa gaa  ctc tct caa ctt caa  gct gca cag gag        8646
Glu  Ile Leu Gln Lys Glu  Leu Ser Gln Leu Gln  Ala Ala Gln Glu            
2810                 2815                 2820                            

aag  cag aaa aca ggt act  gtt atg gat acc aag  gtc gat gaa tta        8691
Lys  Gln Lys Thr Gly Thr  Val Met Asp Thr Lys  Val Asp Glu Leu            
2825                 2830                 2835                            

aca  act gag atc aaa gaa  ctg aaa gaa act ctt  gaa gaa aaa acc        8736
Thr  Thr Glu Ile Lys Glu  Leu Lys Glu Thr Leu  Glu Glu Lys Thr            
2840                 2845                 2850                            

aag  gag gca gat gaa tac  ttg gat aag tac tgt  tcc ttg ctt ata        8781
Lys  Glu Ala Asp Glu Tyr  Leu Asp Lys Tyr Cys  Ser Leu Leu Ile            
2855                 2860                 2865                            

agc  cat gaa aag tta gag  aaa gct aaa gag atg  tta gag aca caa        8826
Ser  His Glu Lys Leu Glu  Lys Ala Lys Glu Met  Leu Glu Thr Gln            
2870                 2875                 2880                            

gtg  gcc cat ctg tgt tca  cag caa tct aaa caa  gat tcc cga ggg        8871
Val  Ala His Leu Cys Ser  Gln Gln Ser Lys Gln  Asp Ser Arg Gly            
2885                 2890                 2895                            

tct  cct ttg cta ggt cca  gtt gtt cca gga cca  tct cca atc cct        8916
Ser  Pro Leu Leu Gly Pro  Val Val Pro Gly Pro  Ser Pro Ile Pro            
2900                 2905                 2910                            

tct  gtt act gaa aag agg  tta tca tct ggc caa  aat aaa gct tca        8961
Ser  Val Thr Glu Lys Arg  Leu Ser Ser Gly Gln  Asn Lys Ala Ser            
2915                 2920                 2925                            

ggc  aag agg caa aga tcc  agt gga ata tgg gag  aat ggt aga gga        9006
Gly  Lys Arg Gln Arg Ser  Ser Gly Ile Trp Glu  Asn Gly Arg Gly            
2930                 2935                 2940                            

cca  aca cct gct acc cca  gag agc ttt tct aaa  aaa agc aag aaa        9051
Pro  Thr Pro Ala Thr Pro  Glu Ser Phe Ser Lys  Lys Ser Lys Lys            
2945                 2950                 2955                            

gca  gtc atg agt ggt att  cac cct gca gaa gac  acg gaa ggt act        9096
Ala  Val Met Ser Gly Ile  His Pro Ala Glu Asp  Thr Glu Gly Thr            
2960                 2965                 2970                            

gag  ttt gag cca gag gga  ctt cca gaa gtt gta  aag aaa ggg ttt        9141
Glu  Phe Glu Pro Glu Gly  Leu Pro Glu Val Val  Lys Lys Gly Phe            
2975                 2980                 2985                            

gct  gac atc ccg aca gga  aag act agc cca tat  atc ctg cga aga        9186
Ala  Asp Ile Pro Thr Gly  Lys Thr Ser Pro Tyr  Ile Leu Arg Arg            
2990                 2995                 3000                            

aca  acc atg gca act cgg  acc agc ccc cgc ctg  gct gca cag aag        9231
Thr  Thr Met Ala Thr Arg  Thr Ser Pro Arg Leu  Ala Ala Gln Lys            
3005                 3010                 3015                            

tta  gcg cta tcc cca ctg  agt ctc ggc aaa gaa  aat ctt gca gag        9276
Leu  Ala Leu Ser Pro Leu  Ser Leu Gly Lys Glu  Asn Leu Ala Glu            
3020                 3025                 3030                            

tcc  tcc aaa cca aca gct  ggt ggc agc aga tca  caa aag gtc aaa        9321
Ser  Ser Lys Pro Thr Ala  Gly Gly Ser Arg Ser  Gln Lys Val Lys            
3035                 3040                 3045                            

gtt  gct cag cgg agc cca  gta gat tca ggc acc  atc ctc cga gaa        9366
Val  Ala Gln Arg Ser Pro  Val Asp Ser Gly Thr  Ile Leu Arg Glu            
3050                 3055                 3060                            

ccc  acc acg aaa tcc gtc  cca gtc aat aat ctt  cct gag aga agt        9411
Pro  Thr Thr Lys Ser Val  Pro Val Asn Asn Leu  Pro Glu Arg Ser            
3065                 3070                 3075                            

ccg  act gac agc ccc aga  gag ggc ctg agg gtc  aag cga ggc cga        9456
Pro  Thr Asp Ser Pro Arg  Glu Gly Leu Arg Val  Lys Arg Gly Arg            
3080                 3085                 3090                            

ctt  gtc ccc agc ccc aaa  gct gga ctg gag tcc  aac ggc agt gag        9501
Leu  Val Pro Ser Pro Lys  Ala Gly Leu Glu Ser  Asn Gly Ser Glu            
3095                 3100                 3105                            

aac  tgt aag gtc cag tga aggcactttg tgtgtcagta cccctgggag             9549
Asn  Cys Lys Val Gln                                                      
3110                                                                      

gtgccagtca ttgaatagat aaggctgtgc ctacaggact tctctttagt cagggcatgc     9609

tttattagtg aggagaaaac aattccttag aagtcttaaa tatattgtac tctttagatc     9669

tcccatgtgt aggtattgaa aaagtttgga agcactgatc acctgttagc attgccattc     9729

ctctactgca atgtaaatag tataaagcta tgtatataaa gctttttggt aatatgttac     9789

aattaaaatg acaagcacta tatcacaatc tctgtttgta tgtgggtttt acactaaaaa     9849

aatgcaaaac acattttatt cttctaatta acagctccta ggaaaatgta gacttttgct     9909

ttatgatatt ctatctgtag tatgaggcat ggaatagttt tgtatcggga atttctcaga     9969

gctgagtaaa atgaaggaaa agcatgttat gtgtttttaa ggaaaatgtg cacacatata    10029

catgtaggag tgtttatctt tctcttacaa tctgttttag acatctttgc ttatgaaacc    10089

tgtacatatg tgtgtgtggg tatgtgttta tttccagtga gggctgcagg cttcctagag    10149

gtgtgctata ccatgcgtct gtcgttgtgc ttttttctgt ttttagacca attttttaca    10209

gttctttggt aagcattgtc gtatctggtg atggattaac atatagcctt tgttttctaa    10269

taaaatagtc gccttcgttt tctgtaaaaa aaaaaaaaaa aaaaaaa                  10316


<210>  2
<211>  3114
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Trp Ala Leu Glu Glu Trp Lys Glu Gly Leu Pro Thr Arg Ala 
1               5                   10                  15      


Leu Gln Lys Ile Gln Glu Leu Glu Gly Gln Leu Asp Lys Leu Lys Lys 
            20                  25                  30          


Glu Lys Gln Gln Arg Gln Phe Gln Leu Asp Ser Leu Glu Ala Ala Leu 
        35                  40                  45              


Gln Lys Gln Lys Gln Lys Val Glu Asn Glu Lys Thr Glu Gly Thr Asn 
    50                  55                  60                  


Leu Lys Arg Glu Asn Gln Arg Leu Met Glu Ile Cys Glu Ser Leu Glu 
65                  70                  75                  80  


Lys Thr Lys Gln Lys Ile Ser His Glu Leu Gln Val Lys Glu Ser Gln 
                85                  90                  95      


Val Asn Phe Gln Glu Gly Gln Leu Asn Ser Gly Lys Lys Gln Ile Glu 
            100                 105                 110         


Lys Leu Glu Gln Glu Leu Lys Arg Cys Lys Ser Glu Leu Glu Arg Ser 
        115                 120                 125             


Gln Gln Ala Ala Gln Ser Ala Asp Val Ser Leu Asn Pro Cys Asn Thr 
    130                 135                 140                 


Pro Gln Lys Ile Phe Thr Thr Pro Leu Thr Pro Ser Gln Tyr Tyr Ser 
145                 150                 155                 160 


Gly Ser Lys Tyr Glu Asp Leu Lys Glu Lys Tyr Asn Lys Glu Val Glu 
                165                 170                 175     


Glu Arg Lys Arg Leu Glu Ala Glu Val Lys Ala Leu Gln Ala Lys Lys 
            180                 185                 190         


Ala Ser Gln Thr Leu Pro Gln Ala Thr Met Asn His Arg Asp Ile Ala 
        195                 200                 205             


Arg His Gln Ala Ser Ser Ser Val Phe Ser Trp Gln Gln Glu Lys Thr 
    210                 215                 220                 


Pro Ser His Leu Ser Ser Asn Ser Gln Arg Thr Pro Ile Arg Arg Asp 
225                 230                 235                 240 


Phe Ser Ala Ser Tyr Phe Ser Gly Glu Gln Glu Val Thr Pro Ser Arg 
                245                 250                 255     


Ser Thr Leu Gln Ile Gly Lys Arg Asp Ala Asn Ser Ser Phe Phe Asp 
            260                 265                 270         


Asn Ser Ser Ser Pro His Leu Leu Asp Gln Leu Lys Ala Gln Asn Gln 
        275                 280                 285             


Glu Leu Arg Asn Lys Ile Asn Glu Leu Glu Leu Arg Leu Gln Gly His 
    290                 295                 300                 


Glu Lys Glu Met Lys Gly Gln Val Asn Lys Phe Gln Glu Leu Gln Leu 
305                 310                 315                 320 


Gln Leu Glu Lys Ala Lys Val Glu Leu Ile Glu Lys Glu Lys Val Leu 
                325                 330                 335     


Asn Lys Cys Arg Asp Glu Leu Val Arg Thr Thr Ala Gln Tyr Asp Gln 
            340                 345                 350         


Ala Ser Thr Lys Tyr Thr Ala Leu Glu Gln Lys Leu Lys Lys Leu Thr 
        355                 360                 365             


Glu Asp Leu Ser Cys Gln Arg Gln Asn Ala Glu Ser Ala Arg Cys Ser 
    370                 375                 380                 


Leu Glu Gln Lys Ile Lys Glu Lys Glu Lys Glu Phe Gln Glu Glu Leu 
385                 390                 395                 400 


Ser Arg Gln Gln Arg Ser Phe Gln Thr Leu Asp Gln Glu Cys Ile Gln 
                405                 410                 415     


Met Lys Ala Arg Leu Thr Gln Glu Leu Gln Gln Ala Lys Asn Met His 
            420                 425                 430         


Asn Val Leu Gln Ala Glu Leu Asp Lys Leu Thr Ser Val Lys Gln Gln 
        435                 440                 445             


Leu Glu Asn Asn Leu Glu Glu Phe Lys Gln Lys Leu Cys Arg Ala Glu 
    450                 455                 460                 


Gln Ala Phe Gln Ala Ser Gln Ile Lys Glu Asn Glu Leu Arg Arg Ser 
465                 470                 475                 480 


Met Glu Glu Met Lys Lys Glu Asn Asn Leu Leu Lys Ser His Ser Glu 
                485                 490                 495     


Gln Lys Ala Arg Glu Val Cys His Leu Glu Ala Glu Leu Lys Asn Ile 
            500                 505                 510         


Lys Gln Cys Leu Asn Gln Ser Gln Asn Phe Ala Glu Glu Met Lys Ala 
        515                 520                 525             


Lys Asn Thr Ser Gln Glu Thr Met Leu Arg Asp Leu Gln Glu Lys Ile 
    530                 535                 540                 


Asn Gln Gln Glu Asn Ser Leu Thr Leu Glu Lys Leu Lys Leu Ala Val 
545                 550                 555                 560 


Ala Asp Leu Glu Lys Gln Arg Asp Cys Ser Gln Asp Leu Leu Lys Lys 
                565                 570                 575     


Arg Glu His His Ile Glu Gln Leu Asn Asp Lys Leu Ser Lys Thr Glu 
            580                 585                 590         


Lys Glu Ser Lys Ala Leu Leu Ser Ala Leu Glu Leu Lys Lys Lys Glu 
        595                 600                 605             


Tyr Glu Glu Leu Lys Glu Glu Lys Thr Leu Phe Ser Cys Trp Lys Ser 
    610                 615                 620                 


Glu Asn Glu Lys Leu Leu Thr Gln Met Glu Ser Glu Lys Glu Asn Leu 
625                 630                 635                 640 


Gln Ser Lys Ile Asn His Leu Glu Thr Cys Leu Lys Thr Gln Gln Ile 
                645                 650                 655     


Lys Ser His Glu Tyr Asn Glu Arg Val Arg Thr Leu Glu Met Asp Arg 
            660                 665                 670         


Glu Asn Leu Ser Val Glu Ile Arg Asn Leu His Asn Val Leu Asp Ser 
        675                 680                 685             


Lys Ser Val Glu Val Glu Thr Gln Lys Leu Ala Tyr Met Glu Leu Gln 
    690                 695                 700                 


Gln Lys Ala Glu Phe Ser Asp Gln Lys His Gln Lys Glu Ile Glu Asn 
705                 710                 715                 720 


Met Cys Leu Lys Thr Ser Gln Leu Thr Gly Gln Val Glu Asp Leu Glu 
                725                 730                 735     


His Lys Leu Gln Leu Leu Ser Asn Glu Ile Met Asp Lys Asp Arg Cys 
            740                 745                 750         


Tyr Gln Asp Leu His Ala Glu Tyr Glu Ser Leu Arg Asp Leu Leu Lys 
        755                 760                 765             


Ser Lys Asp Ala Ser Leu Val Thr Asn Glu Asp His Gln Arg Ser Leu 
    770                 775                 780                 


Leu Ala Phe Asp Gln Gln Pro Ala Met His His Ser Phe Ala Asn Ile 
785                 790                 795                 800 


Ile Gly Glu Gln Gly Ser Met Pro Ser Glu Arg Ser Glu Cys Arg Leu 
                805                 810                 815     


Glu Ala Asp Gln Ser Pro Lys Asn Ser Ala Ile Leu Gln Asn Arg Val 
            820                 825                 830         


Asp Ser Leu Glu Phe Ser Leu Glu Ser Gln Lys Gln Met Asn Ser Asp 
        835                 840                 845             


Leu Gln Lys Gln Cys Glu Glu Leu Val Gln Ile Lys Gly Glu Ile Glu 
    850                 855                 860                 


Glu Asn Leu Met Lys Ala Glu Gln Met His Gln Ser Phe Val Ala Glu 
865                 870                 875                 880 


Thr Ser Gln Arg Ile Ser Lys Leu Gln Glu Asp Thr Ser Ala His Gln 
                885                 890                 895     


Asn Val Val Ala Glu Thr Leu Ser Ala Leu Glu Asn Lys Glu Lys Glu 
            900                 905                 910         


Leu Gln Leu Leu Asn Asp Lys Val Glu Thr Glu Gln Ala Glu Ile Gln 
        915                 920                 925             


Glu Leu Lys Lys Ser Asn His Leu Leu Glu Asp Ser Leu Lys Glu Leu 
    930                 935                 940                 


Gln Leu Leu Ser Glu Thr Leu Ser Leu Glu Lys Lys Glu Met Ser Ser 
945                 950                 955                 960 


Ile Ile Ser Leu Asn Lys Arg Glu Ile Glu Glu Leu Thr Gln Glu Asn 
                965                 970                 975     


Gly Thr Leu Lys Glu Ile Asn Ala Ser Leu Asn Gln Glu Lys Met Asn 
            980                 985                 990         


Leu Ile Gln Lys Ser Glu Ser Phe  Ala Asn Tyr Ile Asp  Glu Arg Glu 
        995                 1000                 1005             


Lys Ser  Ile Ser Glu Leu Ser  Asp Gln Tyr Lys Gln  Glu Lys Leu 
    1010                 1015                 1020             


Ile Leu  Leu Gln Arg Cys Glu  Glu Thr Gly Asn Ala  Tyr Glu Asp 
    1025                 1030                 1035             


Leu Ser  Gln Lys Tyr Lys Ala  Ala Gln Glu Lys Asn  Ser Lys Leu 
    1040                 1045                 1050             


Glu Cys  Leu Leu Asn Glu Cys  Thr Ser Leu Cys Glu  Asn Arg Lys 
    1055                 1060                 1065             


Asn Glu  Leu Glu Gln Leu Lys  Glu Ala Phe Ala Lys  Glu His Gln 
    1070                 1075                 1080             


Glu Phe  Leu Thr Lys Leu Ala  Phe Ala Glu Glu Arg  Asn Gln Asn 
    1085                 1090                 1095             


Leu Met  Leu Glu Leu Glu Thr  Val Gln Gln Ala Leu  Arg Ser Glu 
    1100                 1105                 1110             


Met Thr  Asp Asn Gln Asn Asn  Ser Lys Ser Glu Ala  Gly Gly Leu 
    1115                 1120                 1125             


Lys Gln  Glu Ile Met Thr Leu  Lys Glu Glu Gln Asn  Lys Met Gln 
    1130                 1135                 1140             


Lys Glu  Val Asn Asp Leu Leu  Gln Glu Asn Glu Gln  Leu Met Lys 
    1145                 1150                 1155             


Val Met  Lys Thr Lys His Glu  Cys Gln Asn Leu Glu  Ser Glu Pro 
    1160                 1165                 1170             


Ile Arg  Asn Ser Val Lys Glu  Arg Glu Ser Glu Arg  Asn Gln Cys 
    1175                 1180                 1185             


Asn Phe  Lys Pro Gln Met Asp  Leu Glu Val Lys Glu  Ile Ser Leu 
    1190                 1195                 1200             


Asp Ser  Tyr Asn Ala Gln Leu  Val Gln Leu Glu Ala  Met Leu Arg 
    1205                 1210                 1215             


Asn Lys  Glu Leu Lys Leu Gln  Glu Ser Glu Lys Glu  Lys Glu Cys 
    1220                 1225                 1230             


Leu Gln  His Glu Leu Gln Thr  Ile Arg Gly Asp Leu  Glu Thr Ser 
    1235                 1240                 1245             


Asn Leu  Gln Asp Met Gln Ser  Gln Glu Ile Ser Gly  Leu Lys Asp 
    1250                 1255                 1260             


Cys Glu  Ile Asp Ala Glu Glu  Lys Tyr Ile Ser Gly  Pro His Glu 
    1265                 1270                 1275             


Leu Ser  Thr Ser Gln Asn Asp  Asn Ala His Leu Gln  Cys Ser Leu 
    1280                 1285                 1290             


Gln Thr  Thr Met Asn Lys Leu  Asn Glu Leu Glu Lys  Ile Cys Glu 
    1295                 1300                 1305             


Ile Leu  Gln Ala Glu Lys Tyr  Glu Leu Val Thr Glu  Leu Asn Asp 
    1310                 1315                 1320             


Ser Arg  Ser Glu Cys Ile Thr  Ala Thr Arg Lys Met  Ala Glu Glu 
    1325                 1330                 1335             


Val Gly  Lys Leu Leu Asn Glu  Val Lys Ile Leu Asn  Asp Asp Ser 
    1340                 1345                 1350             


Gly Leu  Leu His Gly Glu Leu  Val Glu Asp Ile Pro  Gly Gly Glu 
    1355                 1360                 1365             


Phe Gly  Glu Gln Pro Asn Glu  Gln His Pro Val Ser  Leu Ala Pro 
    1370                 1375                 1380             


Leu Asp  Glu Ser Asn Ser Tyr  Glu His Leu Thr Leu  Ser Asp Lys 
    1385                 1390                 1395             


Glu Val  Gln Met His Phe Ala  Glu Leu Gln Glu Lys  Phe Leu Ser 
    1400                 1405                 1410             


Leu Gln  Ser Glu His Lys Ile  Leu His Asp Gln His  Cys Gln Met 
    1415                 1420                 1425             


Ser Ser  Lys Met Ser Glu Leu  Gln Thr Tyr Val Asp  Ser Leu Lys 
    1430                 1435                 1440             


Ala Glu  Asn Leu Val Leu Ser  Thr Asn Leu Arg Asn  Phe Gln Gly 
    1445                 1450                 1455             


Asp Leu  Val Lys Glu Met Gln  Leu Gly Leu Glu Glu  Gly Leu Val 
    1460                 1465                 1470             


Pro Ser  Leu Ser Ser Ser Cys  Val Pro Asp Ser Ser  Ser Leu Ser 
    1475                 1480                 1485             


Ser Leu  Gly Asp Ser Ser Phe  Tyr Arg Ala Leu Leu  Glu Gln Thr 
    1490                 1495                 1500             


Gly Asp  Met Ser Leu Leu Ser  Asn Leu Glu Gly Ala  Val Ser Ala 
    1505                 1510                 1515             


Asn Gln  Cys Ser Val Asp Glu  Val Phe Cys Ser Ser  Leu Gln Glu 
    1520                 1525                 1530             


Glu Asn  Leu Thr Arg Lys Glu  Thr Pro Ser Ala Pro  Ala Lys Gly 
    1535                 1540                 1545             


Val Glu  Glu Leu Glu Ser Leu  Cys Glu Val Tyr Arg  Gln Ser Leu 
    1550                 1555                 1560             


Glu Lys  Leu Glu Glu Lys Met  Glu Ser Gln Gly Ile  Met Lys Asn 
    1565                 1570                 1575             


Lys Glu  Ile Gln Glu Leu Glu  Gln Leu Leu Ser Ser  Glu Arg Gln 
    1580                 1585                 1590             


Glu Leu  Asp Cys Leu Arg Lys  Gln Tyr Leu Ser Glu  Asn Glu Gln 
    1595                 1600                 1605             


Trp Gln  Gln Lys Leu Thr Ser  Val Thr Leu Glu Met  Glu Ser Lys 
    1610                 1615                 1620             


Leu Ala  Ala Glu Lys Lys Gln  Thr Glu Gln Leu Ser  Leu Glu Leu 
    1625                 1630                 1635             


Glu Val  Ala Arg Leu Gln Leu  Gln Gly Leu Asp Leu  Ser Ser Arg 
    1640                 1645                 1650             


Ser Leu  Leu Gly Ile Asp Thr  Glu Asp Ala Ile Gln  Gly Arg Asn 
    1655                 1660                 1665             


Glu Ser  Cys Asp Ile Ser Lys  Glu His Thr Ser Glu  Thr Thr Glu 
    1670                 1675                 1680             


Arg Thr  Pro Lys His Asp Val  His Gln Ile Cys Asp  Lys Asp Ala 
    1685                 1690                 1695             


Gln Gln  Asp Leu Asn Leu Asp  Ile Glu Lys Ile Thr  Glu Thr Gly 
    1700                 1705                 1710             


Ala Val  Lys Pro Thr Gly Glu  Cys Ser Gly Glu Gln  Ser Pro Asp 
    1715                 1720                 1725             


Thr Asn  Tyr Glu Pro Pro Gly  Glu Asp Lys Thr Gln  Gly Ser Ser 
    1730                 1735                 1740             


Glu Cys  Ile Ser Glu Leu Ser  Phe Ser Gly Pro Asn  Ala Leu Val 
    1745                 1750                 1755             


Pro Met  Asp Phe Leu Gly Asn  Gln Glu Asp Ile His  Asn Leu Gln 
    1760                 1765                 1770             


Leu Arg  Val Lys Glu Thr Ser  Asn Glu Asn Leu Arg  Leu Leu His 
    1775                 1780                 1785             


Val Ile  Glu Asp Arg Asp Arg  Lys Val Glu Ser Leu  Leu Asn Glu 
    1790                 1795                 1800             


Met Lys  Glu Leu Asp Ser Lys  Leu His Leu Gln Glu  Val Gln Leu 
    1805                 1810                 1815             


Met Thr  Lys Ile Glu Ala Cys  Ile Glu Leu Glu Lys  Ile Val Gly 
    1820                 1825                 1830             


Glu Leu  Lys Lys Glu Asn Ser  Asp Leu Ser Glu Lys  Leu Glu Tyr 
    1835                 1840                 1845             


Phe Ser  Cys Asp His Gln Glu  Leu Leu Gln Arg Val  Glu Thr Ser 
    1850                 1855                 1860             


Glu Gly  Leu Asn Ser Asp Leu  Glu Met His Ala Asp  Lys Ser Ser 
    1865                 1870                 1875             


Arg Glu  Asp Ile Gly Asp Asn  Val Ala Lys Val Asn  Asp Ser Trp 
    1880                 1885                 1890             


Lys Glu  Arg Phe Leu Asp Val  Glu Asn Glu Leu Ser  Arg Ile Arg 
    1895                 1900                 1905             


Ser Glu  Lys Ala Ser Ile Glu  His Glu Ala Leu Tyr  Leu Glu Ala 
    1910                 1915                 1920             


Asp Leu  Glu Val Val Gln Thr  Glu Lys Leu Cys Leu  Glu Lys Asp 
    1925                 1930                 1935             


Asn Glu  Asn Lys Gln Lys Val  Ile Val Cys Leu Glu  Glu Glu Leu 
    1940                 1945                 1950             


Ser Val  Val Thr Ser Glu Arg  Asn Gln Leu Arg Gly  Glu Leu Asp 
    1955                 1960                 1965             


Thr Met  Ser Lys Lys Thr Thr  Ala Leu Asp Gln Leu  Ser Glu Lys 
    1970                 1975                 1980             


Met Lys  Glu Lys Thr Gln Glu  Leu Glu Ser His Gln  Ser Glu Cys 
    1985                 1990                 1995             


Leu His  Cys Ile Gln Val Ala  Glu Ala Glu Val Lys  Glu Lys Thr 
    2000                 2005                 2010             


Glu Leu  Leu Gln Thr Leu Ser  Ser Asp Val Ser Glu  Leu Leu Lys 
    2015                 2020                 2025             


Asp Lys  Thr His Leu Gln Glu  Lys Leu Gln Ser Leu  Glu Lys Asp 
    2030                 2035                 2040             


Ser Gln  Ala Leu Ser Leu Thr  Lys Cys Glu Leu Glu  Asn Gln Ile 
    2045                 2050                 2055             


Ala Gln  Leu Asn Lys Glu Lys  Glu Leu Leu Val Lys  Glu Ser Glu 
    2060                 2065                 2070             


Ser Leu  Gln Ala Arg Leu Ser  Glu Ser Asp Tyr Glu  Lys Leu Asn 
    2075                 2080                 2085             


Val Ser  Lys Ala Leu Glu Ala  Ala Leu Val Glu Lys  Gly Glu Phe 
    2090                 2095                 2100             


Ala Leu  Arg Leu Ser Ser Thr  Gln Glu Glu Val His  Gln Leu Arg 
    2105                 2110                 2115             


Arg Gly  Ile Glu Lys Leu Arg  Val Arg Ile Glu Ala  Asp Glu Lys 
    2120                 2125                 2130             


Lys Gln  Leu His Ile Ala Glu  Lys Leu Lys Glu Arg  Glu Arg Glu 
    2135                 2140                 2145             


Asn Asp  Ser Leu Lys Asp Lys  Val Glu Asn Leu Glu  Arg Glu Leu 
    2150                 2155                 2160             


Gln Met  Ser Glu Glu Asn Gln  Glu Leu Val Ile Leu  Asp Ala Glu 
    2165                 2170                 2175             


Asn Ser  Lys Ala Glu Val Glu  Thr Leu Lys Thr Gln  Ile Glu Glu 
    2180                 2185                 2190             


Met Ala  Arg Ser Leu Lys Val  Phe Glu Leu Asp Leu  Val Thr Leu 
    2195                 2200                 2205             


Arg Ser  Glu Lys Glu Asn Leu  Thr Lys Gln Ile Gln  Glu Lys Gln 
    2210                 2215                 2220             


Gly Gln  Leu Ser Glu Leu Asp  Lys Leu Leu Ser Ser  Phe Lys Ser 
    2225                 2230                 2235             


Leu Leu  Glu Glu Lys Glu Gln  Ala Glu Ile Gln Ile  Lys Glu Glu 
    2240                 2245                 2250             


Ser Lys  Thr Ala Val Glu Met  Leu Gln Asn Gln Leu  Lys Glu Leu 
    2255                 2260                 2265             


Asn Glu  Ala Val Ala Ala Leu  Cys Gly Asp Gln Glu  Ile Met Lys 
    2270                 2275                 2280             


Ala Thr  Glu Gln Ser Leu Asp  Pro Pro Ile Glu Glu  Glu His Gln 
    2285                 2290                 2295             


Leu Arg  Asn Ser Ile Glu Lys  Leu Arg Ala Arg Leu  Glu Ala Asp 
    2300                 2305                 2310             


Glu Lys  Lys Gln Leu Cys Val  Leu Gln Gln Leu Lys  Glu Ser Glu 
    2315                 2320                 2325             


His His  Ala Asp Leu Leu Lys  Gly Arg Val Glu Asn  Leu Glu Arg 
    2330                 2335                 2340             


Glu Leu  Glu Ile Ala Arg Thr  Asn Gln Glu His Ala  Ala Leu Glu 
    2345                 2350                 2355             


Ala Glu  Asn Ser Lys Gly Glu  Val Glu Thr Leu Lys  Ala Lys Ile 
    2360                 2365                 2370             


Glu Gly  Met Thr Gln Ser Leu  Arg Gly Leu Glu Leu  Asp Val Val 
    2375                 2380                 2385             


Thr Ile  Arg Ser Glu Lys Glu  Asn Leu Thr Asn Glu  Leu Gln Lys 
    2390                 2395                 2400             


Glu Gln  Glu Arg Ile Ser Glu  Leu Glu Ile Ile Asn  Ser Ser Phe 
    2405                 2410                 2415             


Glu Asn  Ile Leu Gln Glu Lys  Glu Gln Glu Lys Val  Gln Met Lys 
    2420                 2425                 2430             


Glu Lys  Ser Ser Thr Ala Met  Glu Met Leu Gln Thr  Gln Leu Lys 
    2435                 2440                 2445             


Glu Leu  Asn Glu Arg Val Ala  Ala Leu His Asn Asp  Gln Glu Ala 
    2450                 2455                 2460             


Cys Lys  Ala Lys Glu Gln Asn  Leu Ser Ser Gln Val  Glu Cys Leu 
    2465                 2470                 2475             


Glu Leu  Glu Lys Ala Gln Leu  Leu Gln Gly Leu Asp  Glu Ala Lys 
    2480                 2485                 2490             


Asn Asn  Tyr Ile Val Leu Gln  Ser Ser Val Asn Gly  Leu Ile Gln 
    2495                 2500                 2505             


Glu Val  Glu Asp Gly Lys Gln  Lys Leu Glu Lys Lys  Asp Glu Glu 
    2510                 2515                 2520             


Ile Ser  Arg Leu Lys Asn Gln  Ile Gln Asp Gln Glu  Gln Leu Val 
    2525                 2530                 2535             


Ser Lys  Leu Ser Gln Val Glu  Gly Glu His Gln Leu  Trp Lys Glu 
    2540                 2545                 2550             


Gln Asn  Leu Glu Leu Arg Asn  Leu Thr Val Glu Leu  Glu Gln Lys 
    2555                 2560                 2565             


Ile Gln  Val Leu Gln Ser Lys  Asn Ala Ser Leu Gln  Asp Thr Leu 
    2570                 2575                 2580             


Glu Val  Leu Gln Ser Ser Tyr  Lys Asn Leu Glu Asn  Glu Leu Glu 
    2585                 2590                 2595             


Leu Thr  Lys Met Asp Lys Met  Ser Phe Val Glu Lys  Val Asn Lys 
    2600                 2605                 2610             


Met Thr  Ala Lys Glu Thr Glu  Leu Gln Arg Glu Met  His Glu Met 
    2615                 2620                 2625             


Ala Gln  Lys Thr Ala Glu Leu  Gln Glu Glu Leu Ser  Gly Glu Lys 
    2630                 2635                 2640             


Asn Arg  Leu Ala Gly Glu Leu  Gln Leu Leu Leu Glu  Glu Ile Lys 
    2645                 2650                 2655             


Ser Ser  Lys Asp Gln Leu Lys  Glu Leu Thr Leu Glu  Asn Ser Glu 
    2660                 2665                 2670             


Leu Lys  Lys Ser Leu Asp Cys  Met His Lys Asp Gln  Val Glu Lys 
    2675                 2680                 2685             


Glu Gly  Lys Val Arg Glu Glu  Ile Ala Glu Tyr Gln  Leu Arg Leu 
    2690                 2695                 2700             


His Glu  Ala Glu Lys Lys His  Gln Ala Leu Leu Leu  Asp Thr Asn 
    2705                 2710                 2715             


Lys Gln  Tyr Glu Val Glu Ile  Gln Thr Tyr Arg Glu  Lys Leu Thr 
    2720                 2725                 2730             


Ser Lys  Glu Glu Cys Leu Ser  Ser Gln Lys Leu Glu  Ile Asp Leu 
    2735                 2740                 2745             


Leu Lys  Ser Ser Lys Glu Glu  Leu Asn Asn Ser Leu  Lys Ala Thr 
    2750                 2755                 2760             


Thr Gln  Ile Leu Glu Glu Leu  Lys Lys Thr Lys Met  Asp Asn Leu 
    2765                 2770                 2775             


Lys Tyr  Val Asn Gln Leu Lys  Lys Glu Asn Glu Arg  Ala Gln Gly 
    2780                 2785                 2790             


Lys Met  Lys Leu Leu Ile Lys  Ser Cys Lys Gln Leu  Glu Glu Glu 
    2795                 2800                 2805             


Lys Glu  Ile Leu Gln Lys Glu  Leu Ser Gln Leu Gln  Ala Ala Gln 
    2810                 2815                 2820             


Glu Lys  Gln Lys Thr Gly Thr  Val Met Asp Thr Lys  Val Asp Glu 
    2825                 2830                 2835             


Leu Thr  Thr Glu Ile Lys Glu  Leu Lys Glu Thr Leu  Glu Glu Lys 
    2840                 2845                 2850             


Thr Lys  Glu Ala Asp Glu Tyr  Leu Asp Lys Tyr Cys  Ser Leu Leu 
    2855                 2860                 2865             


Ile Ser  His Glu Lys Leu Glu  Lys Ala Lys Glu Met  Leu Glu Thr 
    2870                 2875                 2880             


Gln Val  Ala His Leu Cys Ser  Gln Gln Ser Lys Gln  Asp Ser Arg 
    2885                 2890                 2895             


Gly Ser  Pro Leu Leu Gly Pro  Val Val Pro Gly Pro  Ser Pro Ile 
    2900                 2905                 2910             


Pro Ser  Val Thr Glu Lys Arg  Leu Ser Ser Gly Gln  Asn Lys Ala 
    2915                 2920                 2925             


Ser Gly  Lys Arg Gln Arg Ser  Ser Gly Ile Trp Glu  Asn Gly Arg 
    2930                 2935                 2940             


Gly Pro  Thr Pro Ala Thr Pro  Glu Ser Phe Ser Lys  Lys Ser Lys 
    2945                 2950                 2955             


Lys Ala  Val Met Ser Gly Ile  His Pro Ala Glu Asp  Thr Glu Gly 
    2960                 2965                 2970             


Thr Glu  Phe Glu Pro Glu Gly  Leu Pro Glu Val Val  Lys Lys Gly 
    2975                 2980                 2985             


Phe Ala  Asp Ile Pro Thr Gly  Lys Thr Ser Pro Tyr  Ile Leu Arg 
    2990                 2995                 3000             


Arg Thr  Thr Met Ala Thr Arg  Thr Ser Pro Arg Leu  Ala Ala Gln 
    3005                 3010                 3015             


Lys Leu  Ala Leu Ser Pro Leu  Ser Leu Gly Lys Glu  Asn Leu Ala 
    3020                 3025                 3030             


Glu Ser  Ser Lys Pro Thr Ala  Gly Gly Ser Arg Ser  Gln Lys Val 
    3035                 3040                 3045             


Lys Val  Ala Gln Arg Ser Pro  Val Asp Ser Gly Thr  Ile Leu Arg 
    3050                 3055                 3060             


Glu Pro  Thr Thr Lys Ser Val  Pro Val Asn Asn Leu  Pro Glu Arg 
    3065                 3070                 3075             


Ser Pro  Thr Asp Ser Pro Arg  Glu Gly Leu Arg Val  Lys Arg Gly 
    3080                 3085                 3090             


Arg Leu  Val Pro Ser Pro Lys  Ala Gly Leu Glu Ser  Asn Gly Ser 
    3095                 3100                 3105             


Glu Asn  Cys Lys Val Gln 
    3110                 


<210>  3
<211>  1687
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (38)..(871)

<400>  3
gattgtggga aggcagctga actcggcgcc tggaaag atg gag gca gcg gag aca        55
                                         Met Glu Ala Ala Glu Thr          
                                         1               5                

gag gcg gaa gct gca gcc cta gag gtc ctg gct gag gtg gca ggc atc        103
Glu Ala Glu Ala Ala Ala Leu Glu Val Leu Ala Glu Val Ala Gly Ile           
            10                  15                  20                    

ttg gaa cct gta ggc ctg cag gag gag gca gaa ctg cca gcc aag atc        151
Leu Glu Pro Val Gly Leu Gln Glu Glu Ala Glu Leu Pro Ala Lys Ile           
        25                  30                  35                        

ctg gtt gag ttt gtg gtg gac tct cag aag aaa gac aag ctg ctc tgc        199
Leu Val Glu Phe Val Val Asp Ser Gln Lys Lys Asp Lys Leu Leu Cys           
    40                  45                  50                            

agc cag ctt cag gta gcg gat ttc ctg cag aac atc ctg gct cag gag        247
Ser Gln Leu Gln Val Ala Asp Phe Leu Gln Asn Ile Leu Ala Gln Glu           
55                  60                  65                  70            

gac act gct aag ggt ctc gac ccc ttg gct tct gaa gac acg agc cga        295
Asp Thr Ala Lys Gly Leu Asp Pro Leu Ala Ser Glu Asp Thr Ser Arg           
                75                  80                  85                

cag aag gca att gca gct aag gaa caa tgg aaa gag ctg aag gcc acc        343
Gln Lys Ala Ile Ala Ala Lys Glu Gln Trp Lys Glu Leu Lys Ala Thr           
            90                  95                  100                   

tac agg gag cac gta gag gcc atc aaa att ggc ctc acc aag gcc ctg        391
Tyr Arg Glu His Val Glu Ala Ile Lys Ile Gly Leu Thr Lys Ala Leu           
        105                 110                 115                       

act cag atg gag gaa gcc cag agg aaa cgg aca caa ctc cgg gaa gcc        439
Thr Gln Met Glu Glu Ala Gln Arg Lys Arg Thr Gln Leu Arg Glu Ala           
    120                 125                 130                           

ttt gag cag ctc cag gcc aag aaa caa atg gcc atg gag aaa cgc aga        487
Phe Glu Gln Leu Gln Ala Lys Lys Gln Met Ala Met Glu Lys Arg Arg           
135                 140                 145                 150           

gca gtc cag aac cag tgg cag cta caa cag gag aag cat ctg cag cat        535
Ala Val Gln Asn Gln Trp Gln Leu Gln Gln Glu Lys His Leu Gln His           
                155                 160                 165               

ctg gcg gag gtt tct gca gag gtg agg gag cgt aag aca ggg act cag        583
Leu Ala Glu Val Ser Ala Glu Val Arg Glu Arg Lys Thr Gly Thr Gln           
            170                 175                 180                   

cag gag ctt gac agg gtg ttt cag aaa ctt gga aac ctg aag cag cag        631
Gln Glu Leu Asp Arg Val Phe Gln Lys Leu Gly Asn Leu Lys Gln Gln           
        185                 190                 195                       

gca gaa cag gag cgg gac aag ctg cag agg tat cag acc ttc ctc cag        679
Ala Glu Gln Glu Arg Asp Lys Leu Gln Arg Tyr Gln Thr Phe Leu Gln           
    200                 205                 210                           

ctt ctg tat acc ctg cag ggt aag ctg ttg ttc cct gag gct gag gct        727
Leu Leu Tyr Thr Leu Gln Gly Lys Leu Leu Phe Pro Glu Ala Glu Ala           
215                 220                 225                 230           

gag gca gag aat ctt cca gat gat aaa ccc cag cag ccg act cga ccc        775
Glu Ala Glu Asn Leu Pro Asp Asp Lys Pro Gln Gln Pro Thr Arg Pro           
                235                 240                 245               

cag gag cag agt aca gga gac acc atg ggg aga gac cct ggt gtg tcc        823
Gln Glu Gln Ser Thr Gly Asp Thr Met Gly Arg Asp Pro Gly Val Ser           
            250                 255                 260                   

ttc aag gct gtt ggt cta caa cct gct gga gat gta aat ttg cca tga        871
Phe Lys Ala Val Gly Leu Gln Pro Ala Gly Asp Val Asn Leu Pro               
        265                 270                 275                       

cttcctggag gacagcagca tggagaaaga tcctagaaaa ggcctctgac ttccctcacc      931

tcccaaccat cattacagga aagactgtga actcctgagt tcagcttgat ttctgactac      991

atcccagcaa gctctggcat ctgtggatta aaatccctgg atctctctca gttgtgtatt     1051

tgttcatctt catatgctgg caggaacaac tattaataca gatactcaga agccaataac     1111

atgacaggag ctgggactgg tttgaacaca gggtgtgcag atggggaggg ggtactggcc     1171

ttgggcctcc tatgatgcag acatggtgaa tttaattcaa ggaggaggag aatgttttag     1231

gcaggtggtt atatgtggga agataatttt attcatggat ccaaatgttt gttgagtcct     1291

ttctttgtgc taaggttctt gcggtgaacc agaattataa cagtgagctc atctgactgt     1351

tttaggatgt acagcctagt gttaacattc ttggtatctt tttgtgcctt atctaaaaca     1411

tttctcgatc actggtttca gatgttcatt tattatattc ttttcaaaga ttcagagatt     1471

ggcttttgtc atccactatt gtatgttttg tttcattgac ctctagtgat accttgatct     1531

ttcccacttt ctgttttcgg attggagaag atgtaccttt tttgtcaact cttactttta     1591

tcagatgatc aactcacgta tttggatctt tatttgtttt ctcaaataaa tatttaaggt     1651

tatacattta aaaaaaaaaa aaaaaaaaaa aaaaaa                               1687


<210>  4
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Ala Ala Glu Thr Glu Ala Glu Ala Ala Ala Leu Glu Val Leu 
1               5                   10                  15      


Ala Glu Val Ala Gly Ile Leu Glu Pro Val Gly Leu Gln Glu Glu Ala 
            20                  25                  30          


Glu Leu Pro Ala Lys Ile Leu Val Glu Phe Val Val Asp Ser Gln Lys 
        35                  40                  45              


Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Ala Asp Phe Leu Gln 
    50                  55                  60                  


Asn Ile Leu Ala Gln Glu Asp Thr Ala Lys Gly Leu Asp Pro Leu Ala 
65                  70                  75                  80  


Ser Glu Asp Thr Ser Arg Gln Lys Ala Ile Ala Ala Lys Glu Gln Trp 
                85                  90                  95      


Lys Glu Leu Lys Ala Thr Tyr Arg Glu His Val Glu Ala Ile Lys Ile 
            100                 105                 110         


Gly Leu Thr Lys Ala Leu Thr Gln Met Glu Glu Ala Gln Arg Lys Arg 
        115                 120                 125             


Thr Gln Leu Arg Glu Ala Phe Glu Gln Leu Gln Ala Lys Lys Gln Met 
    130                 135                 140                 


Ala Met Glu Lys Arg Arg Ala Val Gln Asn Gln Trp Gln Leu Gln Gln 
145                 150                 155                 160 


Glu Lys His Leu Gln His Leu Ala Glu Val Ser Ala Glu Val Arg Glu 
                165                 170                 175     


Arg Lys Thr Gly Thr Gln Gln Glu Leu Asp Arg Val Phe Gln Lys Leu 
            180                 185                 190         


Gly Asn Leu Lys Gln Gln Ala Glu Gln Glu Arg Asp Lys Leu Gln Arg 
        195                 200                 205             


Tyr Gln Thr Phe Leu Gln Leu Leu Tyr Thr Leu Gln Gly Lys Leu Leu 
    210                 215                 220                 


Phe Pro Glu Ala Glu Ala Glu Ala Glu Asn Leu Pro Asp Asp Lys Pro 
225                 230                 235                 240 


Gln Gln Pro Thr Arg Pro Gln Glu Gln Ser Thr Gly Asp Thr Met Gly 
                245                 250                 255     


Arg Asp Pro Gly Val Ser Phe Lys Ala Val Gly Leu Gln Pro Ala Gly 
            260                 265                 270         


Asp Val Asn Leu Pro 
        275         


<210>  5
<211>  2628
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (190)..(1101)

<400>  5
gagcgcctgc cgtttctcgg ggcgggacgg gggggcgggg actgggcgga gaggcgcgtg       60

ctgctgcgtg cgtgcgcgcg cgccgcgggc gggccagtga aaccggcggc cctggcacgt      120

gacctaggac cggctcaccg ggtcgcttgg tggctccgtc tgtctgtccg tccgcccgcg      180

ggtgccatc atg gcg gac gcg gcc agt cag gtg ctc ctg ggc tcc ggt ctc      231
          Met Ala Asp Ala Ala Ser Gln Val Leu Leu Gly Ser Gly Leu         
          1               5                   10                          

acc atc ctg tcc cag ccg ctc atg tac gtg aaa gtg ctc atc cag gtg        279
Thr Ile Leu Ser Gln Pro Leu Met Tyr Val Lys Val Leu Ile Gln Val           
15                  20                  25                  30            

gga tat gag cct ctt cct cca aca ata gga cga aat att ttt ggg cgg        327
Gly Tyr Glu Pro Leu Pro Pro Thr Ile Gly Arg Asn Ile Phe Gly Arg           
                35                  40                  45                

caa gtg tgt cag ctt cct ggt ctc ttt agt tat gct cag cac att gcc        375
Gln Val Cys Gln Leu Pro Gly Leu Phe Ser Tyr Ala Gln His Ile Ala           
            50                  55                  60                    

agt atc gat ggg agg cgc ggg ttg ttc aca ggc tta act cca aga ctg        423
Ser Ile Asp Gly Arg Arg Gly Leu Phe Thr Gly Leu Thr Pro Arg Leu           
        65                  70                  75                        

tgt tcg gga gtc ctt gga act gtg gtc cat ggt aaa gtt tta cag cat        471
Cys Ser Gly Val Leu Gly Thr Val Val His Gly Lys Val Leu Gln His           
    80                  85                  90                            

tac cag gag agt gac aag ggt gag gag tta gga cct gga aat gta cag        519
Tyr Gln Glu Ser Asp Lys Gly Glu Glu Leu Gly Pro Gly Asn Val Gln           
95                  100                 105                 110           

aaa gaa gtc tca tct tcc ttt gac cac gtt atc aag gag aca act cga        567
Lys Glu Val Ser Ser Ser Phe Asp His Val Ile Lys Glu Thr Thr Arg           
                115                 120                 125               

gag atg atc gct cgt tct gct gct acc ctc atc aca cat ccc ttc cat        615
Glu Met Ile Ala Arg Ser Ala Ala Thr Leu Ile Thr His Pro Phe His           
            130                 135                 140                   

gtg atc act ctg aga tct atg gta cag ttc att ggc aga gaa tcc aag        663
Val Ile Thr Leu Arg Ser Met Val Gln Phe Ile Gly Arg Glu Ser Lys           
        145                 150                 155                       

tac tgt gga ctt tgt gat tcc ata ata acc atc tat cgg gaa gag ggc        711
Tyr Cys Gly Leu Cys Asp Ser Ile Ile Thr Ile Tyr Arg Glu Glu Gly           
    160                 165                 170                           

att cta gga ttt ttc gcg ggt ctt gtt cct cgc ctt cta ggt gac atc        759
Ile Leu Gly Phe Phe Ala Gly Leu Val Pro Arg Leu Leu Gly Asp Ile           
175                 180                 185                 190           

ctt tct ttg tgg ctg tgt aac tca ctg gcc tac ctc gtc aat acc tat        807
Leu Ser Leu Trp Leu Cys Asn Ser Leu Ala Tyr Leu Val Asn Thr Tyr           
                195                 200                 205               

gca ctg gac agt ggg gtt tct acc atg aat gaa atg aag agt tat tct        855
Ala Leu Asp Ser Gly Val Ser Thr Met Asn Glu Met Lys Ser Tyr Ser           
            210                 215                 220                   

caa gct gtc aca gga ttt ttt gcg agt atg ttg acc tat ccc ttt gtg        903
Gln Ala Val Thr Gly Phe Phe Ala Ser Met Leu Thr Tyr Pro Phe Val           
        225                 230                 235                       

ctt gtc tcc aat ctt atg gct gtc aac aac tgt ggt ctt gct ggt gga        951
Leu Val Ser Asn Leu Met Ala Val Asn Asn Cys Gly Leu Ala Gly Gly           
    240                 245                 250                           

tgc cct cct tac tcc cca ata tat acg tct tgg ata gac tgt tgg tgc        999
Cys Pro Pro Tyr Ser Pro Ile Tyr Thr Ser Trp Ile Asp Cys Trp Cys           
255                 260                 265                 270           

atg cta caa aaa gag ggg aat atg agc cga gga aat agc tta ttt ttc       1047
Met Leu Gln Lys Glu Gly Asn Met Ser Arg Gly Asn Ser Leu Phe Phe           
                275                 280                 285               

cgg aag gtc ccc ttt ggg aag act tat tgt tgt gac ctg aaa atg tta       1095
Arg Lys Val Pro Phe Gly Lys Thr Tyr Cys Cys Asp Leu Lys Met Leu           
            290                 295                 300                   

att tga agatgtgggg cagggacagt gacatttctg tagtcccaga tgcacagaat        1151
Ile                                                                       
                                                                          

tatgggagag aatgttgatt tctatacagt gtggcgcgct tttttaataa tcatttaatc     1211

ttgggaaaat tcaggtgttt ggtgtctgcc ttttttgttc ttttttccag cacaacataa     1271

cttaccactg atactccccc tttagttatt ctgaattagg atatttttgc tccaaattct     1331

tattttactt aaccagaagg gaaaaaaagt tgtattttcc tgaagctaca ggcactttgt     1391

catgtgattt ttgagtctca atttaaggct ttgtaaaatg aagagtagaa ttccaagaaa     1451

aatgagaaat aattttgtaa aacttaacaa aatcactaaa ttaaactata tgggaggtta     1511

tgaattactt tttcttgggt agaccctaaa atgtcagtag catgcaccag aatctgactc     1571

ccattatgct tctaagcaca tttcattgac cttgtctctc atacttcaag aaaaggacag     1631

tacattgcta cattacccta gaaagtctgt gtgaggatct gccccttcag tctgttattg     1691

caaagtaata aaatgtcacc tacagggagc ctctgagcct actctagttc aagaggctac     1751

ctgaaaaaaa ataaataaga taaagggtca gcaacaacaa agaaaaagac aattacagaa     1811

aataagcaag atttggaaag gaagtataat ggcacttttt tcctcaaagg aagttcttgt     1871

tttcacataa aatatgaaaa gcagatcctg caggagtaac ccccttcttt aagagccaag     1931

tatttgccag tgcttaaatt acaccataca gttctaatta tatataatct tttgttcttc     1991

agttttttgt tttgtttcct ttttgttatt gttgccgaag gtgagtagtt ttgcatttct     2051

gatgacagcc ttggaaagta tatttgtaac tccatgtctg gtaatgccaa cccaagtcga     2111

catgggtctt aggacactga ccacctcaca tgccataccc tcagttaagc atgttaacat     2171

ttataggagg aaaaaaatca ctttgggaga aaataaaatt caactcaagc ataaagcttc     2231

tgtttactca ggccttctaa aaagcaggtt aaaatgctct aaaatgagaa agcctgtggt     2291

ttcacttatt tatataactc actgggacat tgccaaatga gtaagcactt aattcgctgc     2351

ttctgagact tctctgtcaa aacagcccca ctgataatat tagacagaac gagaatgcag     2411

gggtctcttc cctcccctgg ggtttaggaa gctcatgagg agctcggctt aaaatgtctt     2471

tgatgtctct tcctttgtct caaaaagtaa tgtcaatttt atatactatt tcaatattac     2531

tatctgcatt tgttttaata taaaaatgtt tgctgcctac ctttttctcc caaaaaatct     2591

ttaagtaaag atgatctggg aaaatgtgcc atgttta                              2628


<210>  6
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Asp Ala Ala Ser Gln Val Leu Leu Gly Ser Gly Leu Thr Ile 
1               5                   10                  15      


Leu Ser Gln Pro Leu Met Tyr Val Lys Val Leu Ile Gln Val Gly Tyr 
            20                  25                  30          


Glu Pro Leu Pro Pro Thr Ile Gly Arg Asn Ile Phe Gly Arg Gln Val 
        35                  40                  45              


Cys Gln Leu Pro Gly Leu Phe Ser Tyr Ala Gln His Ile Ala Ser Ile 
    50                  55                  60                  


Asp Gly Arg Arg Gly Leu Phe Thr Gly Leu Thr Pro Arg Leu Cys Ser 
65                  70                  75                  80  


Gly Val Leu Gly Thr Val Val His Gly Lys Val Leu Gln His Tyr Gln 
                85                  90                  95      


Glu Ser Asp Lys Gly Glu Glu Leu Gly Pro Gly Asn Val Gln Lys Glu 
            100                 105                 110         


Val Ser Ser Ser Phe Asp His Val Ile Lys Glu Thr Thr Arg Glu Met 
        115                 120                 125             


Ile Ala Arg Ser Ala Ala Thr Leu Ile Thr His Pro Phe His Val Ile 
    130                 135                 140                 


Thr Leu Arg Ser Met Val Gln Phe Ile Gly Arg Glu Ser Lys Tyr Cys 
145                 150                 155                 160 


Gly Leu Cys Asp Ser Ile Ile Thr Ile Tyr Arg Glu Glu Gly Ile Leu 
                165                 170                 175     


Gly Phe Phe Ala Gly Leu Val Pro Arg Leu Leu Gly Asp Ile Leu Ser 
            180                 185                 190         


Leu Trp Leu Cys Asn Ser Leu Ala Tyr Leu Val Asn Thr Tyr Ala Leu 
        195                 200                 205             


Asp Ser Gly Val Ser Thr Met Asn Glu Met Lys Ser Tyr Ser Gln Ala 
    210                 215                 220                 


Val Thr Gly Phe Phe Ala Ser Met Leu Thr Tyr Pro Phe Val Leu Val 
225                 230                 235                 240 


Ser Asn Leu Met Ala Val Asn Asn Cys Gly Leu Ala Gly Gly Cys Pro 
                245                 250                 255     


Pro Tyr Ser Pro Ile Tyr Thr Ser Trp Ile Asp Cys Trp Cys Met Leu 
            260                 265                 270         


Gln Lys Glu Gly Asn Met Ser Arg Gly Asn Ser Leu Phe Phe Arg Lys 
        275                 280                 285             


Val Pro Phe Gly Lys Thr Tyr Cys Cys Asp Leu Lys Met Leu Ile 
    290                 295                 300             


<210>  7
<211>  3760
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (374)..(2233)

<400>  7
agaaacactt ggtttcatgt atgactcata agctgaagca cagacaccac ttccccaatc       60

tacaggagcc attttaacag ctaaaacttg tcggattgct ttttattttc aagctcaaaa      120

gacgatagag aaagaatact tgaaggccaa gaagcttgag agaagaaaaa tttcagaaaa      180

attgtctcaa tttgactaga atatcaatga accaggaaaa ctgaagcacc ttccctaaag      240

aaaacttggg tatacaatta ctccacagac agagctgagg gttttttacc caaatcagtc      300

actggatttt gctgcctgat acgtgaatct tcttggaatt tttctcatgt ggatctaagg      360

ggaatgcttt att atg gct gct gtt gtc caa cag aac gac cta gta ttt         409
               Met Ala Ala Val Val Gln Gln Asn Asp Leu Val Phe            
               1               5                   10                     

gaa ttt gct agt aac gtc atg gag gat gaa cga cag ctt ggt gat cca        457
Glu Phe Ala Ser Asn Val Met Glu Asp Glu Arg Gln Leu Gly Asp Pro           
        15                  20                  25                        

gct att ttt cct gcc gta att gtg gaa cat gtt cct ggt gct gat att        505
Ala Ile Phe Pro Ala Val Ile Val Glu His Val Pro Gly Ala Asp Ile           
    30                  35                  40                            

ctc aat agt tat gcc ggt cta gcc tgt gtg gaa gag ccc aat gac atg        553
Leu Asn Ser Tyr Ala Gly Leu Ala Cys Val Glu Glu Pro Asn Asp Met           
45                  50                  55                  60            

att act gag agt tca ctg gat gtt gct gaa gaa gaa atc ata gac gat        601
Ile Thr Glu Ser Ser Leu Asp Val Ala Glu Glu Glu Ile Ile Asp Asp           
                65                  70                  75                

gat gat gat gac atc acc ctt aca gtt gaa gct tct tgt cat gac ggg        649
Asp Asp Asp Asp Ile Thr Leu Thr Val Glu Ala Ser Cys His Asp Gly           
            80                  85                  90                    

gat gaa aca att gaa act att gag gct gct gag gca ctc ctc aat atg        697
Asp Glu Thr Ile Glu Thr Ile Glu Ala Ala Glu Ala Leu Leu Asn Met           
        95                  100                 105                       

gat tcc cct ggc cct atg ctg gat gaa aaa cga ata aat aat aat ata        745
Asp Ser Pro Gly Pro Met Leu Asp Glu Lys Arg Ile Asn Asn Asn Ile           
    110                 115                 120                           

ttt agt tca cct gaa gat gac atg gtt gtt gcc cca gtc acc cat gtg        793
Phe Ser Ser Pro Glu Asp Asp Met Val Val Ala Pro Val Thr His Val           
125                 130                 135                 140           

tcc gtc aca tta gat ggg att cct gaa gtg atg gaa aca cag cag gtg        841
Ser Val Thr Leu Asp Gly Ile Pro Glu Val Met Glu Thr Gln Gln Val           
                145                 150                 155               

caa gaa aaa tat gca gac tca ccg gga gcc tca tca cca gaa cag cct        889
Gln Glu Lys Tyr Ala Asp Ser Pro Gly Ala Ser Ser Pro Glu Gln Pro           
            160                 165                 170                   

aag agg aaa aaa gga aga aaa act aaa cca cca cga cca gat tcc cca        937
Lys Arg Lys Lys Gly Arg Lys Thr Lys Pro Pro Arg Pro Asp Ser Pro           
        175                 180                 185                       

gcc act acg cca aat ata tct gtg aag aag aaa aac aaa gat gga aag        985
Ala Thr Thr Pro Asn Ile Ser Val Lys Lys Lys Asn Lys Asp Gly Lys           
    190                 195                 200                           

gga aac aca att tat ctt tgg gag ttt tta ctg gca ctg ctc cag gac       1033
Gly Asn Thr Ile Tyr Leu Trp Glu Phe Leu Leu Ala Leu Leu Gln Asp           
205                 210                 215                 220           

aag gct act tgt cct aaa tac atc aag tgg acc cag cga gag aaa ggc       1081
Lys Ala Thr Cys Pro Lys Tyr Ile Lys Trp Thr Gln Arg Glu Lys Gly           
                225                 230                 235               

att ttt aaa ttg gtg gat tct aaa gca gtg tcc agg ttg tgg ggg aag       1129
Ile Phe Lys Leu Val Asp Ser Lys Ala Val Ser Arg Leu Trp Gly Lys           
            240                 245                 250                   

cac aaa aac aaa cct gat atg aat tat gag acc atg gga aga gca ctc       1177
His Lys Asn Lys Pro Asp Met Asn Tyr Glu Thr Met Gly Arg Ala Leu           
        255                 260                 265                       

agg tac tat tac caa agg ggt att ctg gca aaa gtg gaa ggt cag cgc       1225
Arg Tyr Tyr Tyr Gln Arg Gly Ile Leu Ala Lys Val Glu Gly Gln Arg           
    270                 275                 280                           

ttg gtg tat cag ttt aaa gaa atg cca aaa gat ctt ata tat ata aat       1273
Leu Val Tyr Gln Phe Lys Glu Met Pro Lys Asp Leu Ile Tyr Ile Asn           
285                 290                 295                 300           

gat gag gat cca agt tcc agc ata gag tct tca gat cca tcg cta tct       1321
Asp Glu Asp Pro Ser Ser Ser Ile Glu Ser Ser Asp Pro Ser Leu Ser           
                305                 310                 315               

tca tca gcc act tca aat agg aat caa acc agc cgg tcg aga gta tct       1369
Ser Ser Ala Thr Ser Asn Arg Asn Gln Thr Ser Arg Ser Arg Val Ser           
            320                 325                 330                   

tca agt cca ggg gta aaa gga gga gcc act aca gtt cta aaa cca ggg       1417
Ser Ser Pro Gly Val Lys Gly Gly Ala Thr Thr Val Leu Lys Pro Gly           
        335                 340                 345                       

aat tct aaa gct gca aaa ccc aaa gat cct gtg gaa gtt gca caa cca       1465
Asn Ser Lys Ala Ala Lys Pro Lys Asp Pro Val Glu Val Ala Gln Pro           
    350                 355                 360                           

tca gaa gtt ttg agg aca gtg cag ccc acg cag tct cca tat cct acc       1513
Ser Glu Val Leu Arg Thr Val Gln Pro Thr Gln Ser Pro Tyr Pro Thr           
365                 370                 375                 380           

cag ctc ttc cgg act gtt cat gta gta cag cca gta cag gct gtc cca       1561
Gln Leu Phe Arg Thr Val His Val Val Gln Pro Val Gln Ala Val Pro           
                385                 390                 395               

gag gga gaa gca gct aga acc agt acc atg cag gat gaa aca tta aat       1609
Glu Gly Glu Ala Ala Arg Thr Ser Thr Met Gln Asp Glu Thr Leu Asn           
            400                 405                 410                   

tct tcc gtt cag agt att agg act ata cag gct cca acc caa gtt cca       1657
Ser Ser Val Gln Ser Ile Arg Thr Ile Gln Ala Pro Thr Gln Val Pro           
        415                 420                 425                       

gtg gtt gtg tct cct agg aat cag cag ttg cat aca gta aca ctc caa       1705
Val Val Val Ser Pro Arg Asn Gln Gln Leu His Thr Val Thr Leu Gln           
    430                 435                 440                           

aca gtg cca ctc aca aca gtt ata gcc agc aca gat cca tca gca ggt       1753
Thr Val Pro Leu Thr Thr Val Ile Ala Ser Thr Asp Pro Ser Ala Gly           
445                 450                 455                 460           

act gga tct cag aag ttt att tta caa gcc att cca tca tca cag ccc       1801
Thr Gly Ser Gln Lys Phe Ile Leu Gln Ala Ile Pro Ser Ser Gln Pro           
                465                 470                 475               

atg aca gta ctg aaa gaa aat gtc atg ctg cag tca caa aag gcg ggc       1849
Met Thr Val Leu Lys Glu Asn Val Met Leu Gln Ser Gln Lys Ala Gly           
            480                 485                 490                   

tct cct cct tca att gtc ttg ggc cct gcc cag gtt cag cag gtc ctt       1897
Ser Pro Pro Ser Ile Val Leu Gly Pro Ala Gln Val Gln Gln Val Leu           
        495                 500                 505                       

act agc aat gtt cag acc att tgc aat gga acc gtc agt gtg gct tcc       1945
Thr Ser Asn Val Gln Thr Ile Cys Asn Gly Thr Val Ser Val Ala Ser           
    510                 515                 520                           

tct cca tcc ttc agt gct act gca cct gtg gtg acc ttt tct cct cgc       1993
Ser Pro Ser Phe Ser Ala Thr Ala Pro Val Val Thr Phe Ser Pro Arg           
525                 530                 535                 540           

agt tca cag ctg gtt gct cac cca cct ggc act gta atc act tca gtt       2041
Ser Ser Gln Leu Val Ala His Pro Pro Gly Thr Val Ile Thr Ser Val           
                545                 550                 555               

atc aaa act caa gaa aca aaa act ctt aca cag gaa gta gag aaa aag       2089
Ile Lys Thr Gln Glu Thr Lys Thr Leu Thr Gln Glu Val Glu Lys Lys           
            560                 565                 570                   

gaa tct gaa gat cat ttg aaa gag aac act gag aaa acg gag cag cag       2137
Glu Ser Glu Asp His Leu Lys Glu Asn Thr Glu Lys Thr Glu Gln Gln           
        575                 580                 585                       

cca cag cct tat gtg atg gta gtg tcc agt tcc aat gga ttt act tct       2185
Pro Gln Pro Tyr Val Met Val Val Ser Ser Ser Asn Gly Phe Thr Ser           
    590                 595                 600                           

cag gta gct atg aaa caa aac gaa ctg ctg gaa ccc aac tct ttt tag       2233
Gln Val Ala Met Lys Gln Asn Glu Leu Leu Glu Pro Asn Ser Phe               
605                 610                 615                               

ttaatatacc aaagcttatg aataattgtt tgttaattga acattttcaa ttatatgcag     2293

actgactgat tctaagataa attctaagga ggtttctaat tttgtaattg ttaaaaatag     2353

agttaatttt gactttgtta gatgagggag gaaaactcaa ctgtttctct ttgttatcta     2413

aatgtttcag aattcaatcg tgaaggaaca ggcattttac actatgaaga cattcttttg     2473

agatttttat ttcagttgct atatcataag catttttaaa gtttcttttc taattttaca     2533

ttgtattaga ttttctgatt cttttgtaaa tacagaactt aaatagaagg caacaggaaa     2593

tttatatagg aactattttc attccacttg tgtaagttaa gtcttgactc tttcaaatgc     2653

aaaaaaccta ttttatgctt tgttaaaatt atggtgtcac ttagattgac tttagttgac     2713

tgcactatat aatatagaac tatgaatatg tagaataaca tgaaaaattg gaggtgctgg     2773

tggtatggct gaccctgttt cagaagcagg atagtataaa agcatcagcc taagaatggc     2833

actcccacta actagctatg taatcttgac ctctttgggc tttagttcct ctcataaaag     2893

gaagagatgt attggattag actagatgat caccactttc tcttctagtt ctaatttttt     2953

taattctaat acctatattt tcaagttatg tcaattaaat cattatcagg ttatttccta     3013

atgtaagaat agctaaaatg ttgcagagaa ataagtgacc caacaaaatt tattcatctg     3073

ttatgggtaa gatctgccat aaattcttcc taaataattt gtttactaac tctttaggcc     3133

actgtgcttt gcggtccatt agtaaacttg tgttgctaag tgctaaacag aatactgcta     3193

ttttgagaga gtcaagactc tttcttaagg gccaagaaag caacttgagc cttgggctaa     3253

tctggctgag tagtcagtta taaaagcata attgctttat attttggatc attttttact     3313

gggggcggac ttgggggggg ttgcatacaa agataacata tatatccaac tttctgaaat     3373

gaaatgtttt tagattactt tttcaactgt aaataatgta catttaatgt cacaagaaaa     3433

aaatgtcttc tgcaaatttt ctagtataac agaaattttt gtagatgaaa aaaatcatta     3493

tgtttagagg tctaatgcta tgttttcata ttacagagtg aatttgtatt taaacaaaaa     3553

tttaaatttt ggaatcctct aaacattttt gtatctttaa ttggtttatt attaaataaa     3613

tcatataaaa attctcagtg tctgttttca ggcaaaagtt tcttaaagaa taagtgtgca     3673

gagaatatta ctagaacatc agcattactt aatgtttata aataaatttc attagtcaga     3733

attgcaaaaa aaaaaaaaaa aaaaaaa                                         3760


<210>  8
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Ala Val Val Gln Gln Asn Asp Leu Val Phe Glu Phe Ala Ser 
1               5                   10                  15      


Asn Val Met Glu Asp Glu Arg Gln Leu Gly Asp Pro Ala Ile Phe Pro 
            20                  25                  30          


Ala Val Ile Val Glu His Val Pro Gly Ala Asp Ile Leu Asn Ser Tyr 
        35                  40                  45              


Ala Gly Leu Ala Cys Val Glu Glu Pro Asn Asp Met Ile Thr Glu Ser 
    50                  55                  60                  


Ser Leu Asp Val Ala Glu Glu Glu Ile Ile Asp Asp Asp Asp Asp Asp 
65                  70                  75                  80  


Ile Thr Leu Thr Val Glu Ala Ser Cys His Asp Gly Asp Glu Thr Ile 
                85                  90                  95      


Glu Thr Ile Glu Ala Ala Glu Ala Leu Leu Asn Met Asp Ser Pro Gly 
            100                 105                 110         


Pro Met Leu Asp Glu Lys Arg Ile Asn Asn Asn Ile Phe Ser Ser Pro 
        115                 120                 125             


Glu Asp Asp Met Val Val Ala Pro Val Thr His Val Ser Val Thr Leu 
    130                 135                 140                 


Asp Gly Ile Pro Glu Val Met Glu Thr Gln Gln Val Gln Glu Lys Tyr 
145                 150                 155                 160 


Ala Asp Ser Pro Gly Ala Ser Ser Pro Glu Gln Pro Lys Arg Lys Lys 
                165                 170                 175     


Gly Arg Lys Thr Lys Pro Pro Arg Pro Asp Ser Pro Ala Thr Thr Pro 
            180                 185                 190         


Asn Ile Ser Val Lys Lys Lys Asn Lys Asp Gly Lys Gly Asn Thr Ile 
        195                 200                 205             


Tyr Leu Trp Glu Phe Leu Leu Ala Leu Leu Gln Asp Lys Ala Thr Cys 
    210                 215                 220                 


Pro Lys Tyr Ile Lys Trp Thr Gln Arg Glu Lys Gly Ile Phe Lys Leu 
225                 230                 235                 240 


Val Asp Ser Lys Ala Val Ser Arg Leu Trp Gly Lys His Lys Asn Lys 
                245                 250                 255     


Pro Asp Met Asn Tyr Glu Thr Met Gly Arg Ala Leu Arg Tyr Tyr Tyr 
            260                 265                 270         


Gln Arg Gly Ile Leu Ala Lys Val Glu Gly Gln Arg Leu Val Tyr Gln 
        275                 280                 285             


Phe Lys Glu Met Pro Lys Asp Leu Ile Tyr Ile Asn Asp Glu Asp Pro 
    290                 295                 300                 


Ser Ser Ser Ile Glu Ser Ser Asp Pro Ser Leu Ser Ser Ser Ala Thr 
305                 310                 315                 320 


Ser Asn Arg Asn Gln Thr Ser Arg Ser Arg Val Ser Ser Ser Pro Gly 
                325                 330                 335     


Val Lys Gly Gly Ala Thr Thr Val Leu Lys Pro Gly Asn Ser Lys Ala 
            340                 345                 350         


Ala Lys Pro Lys Asp Pro Val Glu Val Ala Gln Pro Ser Glu Val Leu 
        355                 360                 365             


Arg Thr Val Gln Pro Thr Gln Ser Pro Tyr Pro Thr Gln Leu Phe Arg 
    370                 375                 380                 


Thr Val His Val Val Gln Pro Val Gln Ala Val Pro Glu Gly Glu Ala 
385                 390                 395                 400 


Ala Arg Thr Ser Thr Met Gln Asp Glu Thr Leu Asn Ser Ser Val Gln 
                405                 410                 415     


Ser Ile Arg Thr Ile Gln Ala Pro Thr Gln Val Pro Val Val Val Ser 
            420                 425                 430         


Pro Arg Asn Gln Gln Leu His Thr Val Thr Leu Gln Thr Val Pro Leu 
        435                 440                 445             


Thr Thr Val Ile Ala Ser Thr Asp Pro Ser Ala Gly Thr Gly Ser Gln 
    450                 455                 460                 


Lys Phe Ile Leu Gln Ala Ile Pro Ser Ser Gln Pro Met Thr Val Leu 
465                 470                 475                 480 


Lys Glu Asn Val Met Leu Gln Ser Gln Lys Ala Gly Ser Pro Pro Ser 
                485                 490                 495     


Ile Val Leu Gly Pro Ala Gln Val Gln Gln Val Leu Thr Ser Asn Val 
            500                 505                 510         


Gln Thr Ile Cys Asn Gly Thr Val Ser Val Ala Ser Ser Pro Ser Phe 
        515                 520                 525             


Ser Ala Thr Ala Pro Val Val Thr Phe Ser Pro Arg Ser Ser Gln Leu 
    530                 535                 540                 


Val Ala His Pro Pro Gly Thr Val Ile Thr Ser Val Ile Lys Thr Gln 
545                 550                 555                 560 


Glu Thr Lys Thr Leu Thr Gln Glu Val Glu Lys Lys Glu Ser Glu Asp 
                565                 570                 575     


His Leu Lys Glu Asn Thr Glu Lys Thr Glu Gln Gln Pro Gln Pro Tyr 
            580                 585                 590         


Val Met Val Val Ser Ser Ser Asn Gly Phe Thr Ser Gln Val Ala Met 
        595                 600                 605             


Lys Gln Asn Glu Leu Leu Glu Pro Asn Ser Phe 
    610                 615                 


<210>  9
<211>  2601
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (192)..(1016)

<400>  9
ccgcccttgt aggctgtcca cctcaaacgg gccggacagg atatataaga gagaatgcac       60

cgtgcactac acacgcgact cccacaaggt tgcagccgga gccgcccagc tcaccgagag      120

cctagttccg gccagggtcg ccccggcaac cacgagccca gccaatcagc gccccggact      180

gcaccagagc c atg gtc ggc aga aga gca ctg atc gta ctg gct cac tca       230
             Met Val Gly Arg Arg Ala Leu Ile Val Leu Ala His Ser          
             1               5                   10                       

gag agg acg tcc ttc aac tat gcc atg aag gag gct gct gca gcg gct        278
Glu Arg Thr Ser Phe Asn Tyr Ala Met Lys Glu Ala Ala Ala Ala Ala           
    15                  20                  25                            

ttg aag aag aaa gga tgg gag gtg gtg gag tcg gac ctc tat gcc atg        326
Leu Lys Lys Lys Gly Trp Glu Val Val Glu Ser Asp Leu Tyr Ala Met           
30                  35                  40                  45            

aac ttc aat ccc atc att tcc aga aag gac atc aca ggt aaa ctg aag        374
Asn Phe Asn Pro Ile Ile Ser Arg Lys Asp Ile Thr Gly Lys Leu Lys           
                50                  55                  60                

gac cct gcg aac ttt cag tat cct gcc gag tct gtt ctg gct tat aaa        422
Asp Pro Ala Asn Phe Gln Tyr Pro Ala Glu Ser Val Leu Ala Tyr Lys           
            65                  70                  75                    

gaa ggc cat ctg agc cca gat att gtg gct gaa caa aag aag ctg gaa        470
Glu Gly His Leu Ser Pro Asp Ile Val Ala Glu Gln Lys Lys Leu Glu           
        80                  85                  90                        

gcc gca gac ctt gtg ata ttc cag ttc ccc ctg cag tgg ttt gga gtc        518
Ala Ala Asp Leu Val Ile Phe Gln Phe Pro Leu Gln Trp Phe Gly Val           
    95                  100                 105                           

cct gcc att ctg aaa ggc tgg ttt gag cga gtg ttc ata gga gag ttt        566
Pro Ala Ile Leu Lys Gly Trp Phe Glu Arg Val Phe Ile Gly Glu Phe           
110                 115                 120                 125           

gct tac act tac gct gcc atg tat gac aaa gga ccc ttc cgg agt aag        614
Ala Tyr Thr Tyr Ala Ala Met Tyr Asp Lys Gly Pro Phe Arg Ser Lys           
                130                 135                 140               

aag gca gtg ctt tcc atc acc act ggt ggc agt ggc tcc atg tac tct        662
Lys Ala Val Leu Ser Ile Thr Thr Gly Gly Ser Gly Ser Met Tyr Ser           
            145                 150                 155                   

ctg caa ggg atc cac ggg gac atg aat gtc att ctc tgg cca att cag        710
Leu Gln Gly Ile His Gly Asp Met Asn Val Ile Leu Trp Pro Ile Gln           
        160                 165                 170                       

agt ggc att ctg cat ttc tgt ggc ttc caa gtc tta gaa cct caa ctg        758
Ser Gly Ile Leu His Phe Cys Gly Phe Gln Val Leu Glu Pro Gln Leu           
    175                 180                 185                           

aca tat agc att ggg cac act cca gca gac gcc cga att caa atc ctg        806
Thr Tyr Ser Ile Gly His Thr Pro Ala Asp Ala Arg Ile Gln Ile Leu           
190                 195                 200                 205           

gaa gga tgg aag aaa cgc ctg gag aat att tgg gat gag aca cca ctg        854
Glu Gly Trp Lys Lys Arg Leu Glu Asn Ile Trp Asp Glu Thr Pro Leu           
                210                 215                 220               

tat ttt gct cca agc agc ctc ttt gac cta aac ttc cag gca gga ttc        902
Tyr Phe Ala Pro Ser Ser Leu Phe Asp Leu Asn Phe Gln Ala Gly Phe           
            225                 230                 235                   

tta atg aaa aaa gag gta cag gat gag gag aaa aac aag aaa ttt ggc        950
Leu Met Lys Lys Glu Val Gln Asp Glu Glu Lys Asn Lys Lys Phe Gly           
        240                 245                 250                       

ctt tct gtg ggc cat cac ttg ggc aag tcc atc cca act gac aac cag        998
Leu Ser Val Gly His His Leu Gly Lys Ser Ile Pro Thr Asp Asn Gln           
    255                 260                 265                           

atc aaa gct aga aaa tga gattccttag cctggatttc cttctaacat              1046
Ile Lys Ala Arg Lys                                                       
270                                                                       

gttatcaaat ctgggtatct ttccaggctt ccctgacttg ctttagtttt taagatttgt     1106

gtttttcttt ttccacaagg aataaatgag agggaatcga ctgtattcgt gcatttttgg     1166

atcattttta actgattctt atgattacta tcatggcata taaccaaaat ccgactgggc     1226

tcaagaggcc acttagggaa agatgtagaa agatgctaga aaaatgttct ttaaaggcat     1286

ctacacaatt taattcctct ttttagggct aaagttttag ggtacagttt ggctaggtat     1346

cattcaactc tccaatgttc tattaatcac ctctctgtag tttatggcag aagggaattg     1406

ctcagagaag gaaaagactg aatctacctg ccctaaggga cttaacttgt ttggtagtta     1466

gccatctaat gcttgtttat gatatttctt gctttcaatt acaaagcagt tactaatatg     1526

cctagcacaa gtaccactct tggtcagctt ttgttgttta tatacagtac acagatacct     1586

tgaaaggaag agctaataaa tctcttcttt gctgcagtca tctacttttt ttttaattaa     1646

aaaaaatttt tttttgaagc agtcttgctc tgttacccag gctggagtgc agtggtgtga     1706

tctcggctca ctgcaacctc tgcctcccag gttccagcaa ttctcctgcc tcagcctccc     1766

tagtagctgg gatgacaggc gcctgccatc atgcctgact aatttttgta tttttagtag     1826

agacggcgtt tcaccatgtt ggccaggctg gtctcaaact cctgacctca ggtgatccgc     1886

ctacctcagc ctcccaaagt gctgggatta caggcgtgat ccaccacacc tggcccttgc     1946

aatcttctac tttaaggttt gcagagataa accaataaat ccacaccgta catctgcaat     2006

atgaattcaa gaaaggaaat agtaccttca atacttaaaa atagtcttcc acaaaaaata     2066

ctttatttct gatctataca aattttcaga aggttatttt ctttatcatt gctaaactga     2126

tgacttacta tgggatgggg tccagtccca tgaccttggg gtacaattgt aaacctagag     2186

ttttatcaac tttggtgaac agttttggca taatagtcaa tttctacttc tggaagtcat     2246

ctcattccac tgttggtatt atataattca aggagaatat gataaaacac tgccctcttg     2306

tggtgcattg aaagaagaga tgagaaatga tgaaaaggtt gcctgaaaaa tgggagacag     2366

cctcttactt gccaagaaaa tgaagggatt ggaccgagct ggaaaacctc ctttaccaga     2426

tgctgactgg cactggtggt ttttgctctc gacagtatcc acaatagctg acggctgggt     2486

gtttcagttt gaaaatattt tgttgccttc atcttcactg caattttgtg taaatttctc     2546

aaagatctga attaaataaa taaaattcat ttctacagac ccacaaaaaa aaaaa          2601


<210>  10
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Val Gly Arg Arg Ala Leu Ile Val Leu Ala His Ser Glu Arg Thr 
1               5                   10                  15      


Ser Phe Asn Tyr Ala Met Lys Glu Ala Ala Ala Ala Ala Leu Lys Lys 
            20                  25                  30          


Lys Gly Trp Glu Val Val Glu Ser Asp Leu Tyr Ala Met Asn Phe Asn 
        35                  40                  45              


Pro Ile Ile Ser Arg Lys Asp Ile Thr Gly Lys Leu Lys Asp Pro Ala 
    50                  55                  60                  


Asn Phe Gln Tyr Pro Ala Glu Ser Val Leu Ala Tyr Lys Glu Gly His 
65                  70                  75                  80  


Leu Ser Pro Asp Ile Val Ala Glu Gln Lys Lys Leu Glu Ala Ala Asp 
                85                  90                  95      


Leu Val Ile Phe Gln Phe Pro Leu Gln Trp Phe Gly Val Pro Ala Ile 
            100                 105                 110         


Leu Lys Gly Trp Phe Glu Arg Val Phe Ile Gly Glu Phe Ala Tyr Thr 
        115                 120                 125             


Tyr Ala Ala Met Tyr Asp Lys Gly Pro Phe Arg Ser Lys Lys Ala Val 
    130                 135                 140                 


Leu Ser Ile Thr Thr Gly Gly Ser Gly Ser Met Tyr Ser Leu Gln Gly 
145                 150                 155                 160 


Ile His Gly Asp Met Asn Val Ile Leu Trp Pro Ile Gln Ser Gly Ile 
                165                 170                 175     


Leu His Phe Cys Gly Phe Gln Val Leu Glu Pro Gln Leu Thr Tyr Ser 
            180                 185                 190         


Ile Gly His Thr Pro Ala Asp Ala Arg Ile Gln Ile Leu Glu Gly Trp 
        195                 200                 205             


Lys Lys Arg Leu Glu Asn Ile Trp Asp Glu Thr Pro Leu Tyr Phe Ala 
    210                 215                 220                 


Pro Ser Ser Leu Phe Asp Leu Asn Phe Gln Ala Gly Phe Leu Met Lys 
225                 230                 235                 240 


Lys Glu Val Gln Asp Glu Glu Lys Asn Lys Lys Phe Gly Leu Ser Val 
                245                 250                 255     


Gly His His Leu Gly Lys Ser Ile Pro Thr Asp Asn Gln Ile Lys Ala 
            260                 265                 270         


Arg Lys 
        


<210>  11
<211>  3993
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (606)..(2594)

<400>  11
ggatttctag gaggaccggc agaggcgcgc ataggtgcgt ggtgctgggc ccgggcgccg       60

cggcaccggt gtaggagcgc gcatctccag agtttcttcc atctgggcga cgtctcggtg      120

cctgcggcgg gaacggcgct ttgcttccct gaggagcttc tagagagcta cggtggcccc      180

cgtgtgggag gcggggggcg tggcggcgtc ggggcgtcgc tgtcccctcc tcggtagctc      240

tcctccctcc cctttctgct gttaccggga gcgcggtggc cacggaacgc tgcccggagc      300

cgcgcgaggg aggacccgac gcgcggcgtt tacccagcgc agcgttccac cgctcgggtt      360

tggctggata aaataaaaaa tggggatatt gacctcctgt cactactgca tggactttga      420

tggtttccaa tcattacttt ctcctctgtg tcaatctgcc tcttcgagaa attcatactc      480

ctgaatagct ctccagaccc ccagctggcc atgtggtgag ttcagggccc aaatcaagta      540

gtaccagcaa tcagggaact cctatctgtt ttgaatggat tcacaccagc cacaagcctg      600

gaaag atg gtg tca caa tct aca gtc agg cag gat tct cct gtg gag ccc      650
      Met Val Ser Gln Ser Thr Val Arg Gln Asp Ser Pro Val Glu Pro         
      1               5                   10                  15          

tgg gaa ggg atc agc gat cac tct ggc att att gat ggt tcg ccc aga        698
Trp Glu Gly Ile Ser Asp His Ser Gly Ile Ile Asp Gly Ser Pro Arg           
                20                  25                  30                

ctc ctg aac act gac cat cct cct tgc caa tta gac atc agg ctc atg        746
Leu Leu Asn Thr Asp His Pro Pro Cys Gln Leu Asp Ile Arg Leu Met           
            35                  40                  45                    

agg cac aaa gct gtc tgg att aac ccc cag gat gtg cag caa cag ccg        794
Arg His Lys Ala Val Trp Ile Asn Pro Gln Asp Val Gln Gln Gln Pro           
        50                  55                  60                        

cag gac ttg caa tct cag gtg cca gca gca ggg aac agt ggg acc cat        842
Gln Asp Leu Gln Ser Gln Val Pro Ala Ala Gly Asn Ser Gly Thr His           
    65                  70                  75                            

ttt gtg aca gat gct gcc tct ccc tca ggc cct tca cct tcg tgc ctc        890
Phe Val Thr Asp Ala Ala Ser Pro Ser Gly Pro Ser Pro Ser Cys Leu           
80                  85                  90                  95            

ggg gac tcc ctg gca gag aca acg ttg tct gag gat acc aca gac tcc        938
Gly Asp Ser Leu Ala Glu Thr Thr Leu Ser Glu Asp Thr Thr Asp Ser           
                100                 105                 110               

gtt ggc agc gct tct ccc cat ggc tcg agt gaa aag agt agc agc ttc        986
Val Gly Ser Ala Ser Pro His Gly Ser Ser Glu Lys Ser Ser Ser Phe           
            115                 120                 125                   

tct ctg tcc tca aca gag gta cac atg gtc cgc cca gga tac tct cat       1034
Ser Leu Ser Ser Thr Glu Val His Met Val Arg Pro Gly Tyr Ser His           
        130                 135                 140                       

cgg gtg tct ctg ccc aca agc cct ggg att ttg gcc acc tcc cca tat       1082
Arg Val Ser Leu Pro Thr Ser Pro Gly Ile Leu Ala Thr Ser Pro Tyr           
    145                 150                 155                           

cct gag act gac agt gct ttt ttt gag cct tcc cat ctg aca tct gct       1130
Pro Glu Thr Asp Ser Ala Phe Phe Glu Pro Ser His Leu Thr Ser Ala           
160                 165                 170                 175           

gct gat gaa ggt gct gtt caa gtc agt aga aga acc att tct tcg aat       1178
Ala Asp Glu Gly Ala Val Gln Val Ser Arg Arg Thr Ile Ser Ser Asn           
                180                 185                 190               

tcc ttc tca cca gag gta ttt gtg ctg cct gtt gat gta gaa aag gaa       1226
Ser Phe Ser Pro Glu Val Phe Val Leu Pro Val Asp Val Glu Lys Glu           
            195                 200                 205                   

aat gcc cac ttt tat gtt gca gat atg att ata tca gca atg gag aaa       1274
Asn Ala His Phe Tyr Val Ala Asp Met Ile Ile Ser Ala Met Glu Lys           
        210                 215                 220                       

atg aag tgt aac att ctg agt caa cag cag aca gag agc tgg agt aaa       1322
Met Lys Cys Asn Ile Leu Ser Gln Gln Gln Thr Glu Ser Trp Ser Lys           
    225                 230                 235                           

gaa gtc agt ggg tta ctt ggg agt gat cag cct gac tct gaa atg act       1370
Glu Val Ser Gly Leu Leu Gly Ser Asp Gln Pro Asp Ser Glu Met Thr           
240                 245                 250                 255           

ttt gat acc aac ata aag caa gag tct ggg tct tct act tct tca tac       1418
Phe Asp Thr Asn Ile Lys Gln Glu Ser Gly Ser Ser Thr Ser Ser Tyr           
                260                 265                 270               

agt ggc tat gaa ggt tgt gct gtg tta cag gtc agc cca gtg act gaa       1466
Ser Gly Tyr Glu Gly Cys Ala Val Leu Gln Val Ser Pro Val Thr Glu           
            275                 280                 285                   

aca cgt act tac cat gat gtg aaa gag att tgc aaa tgc gat gtt gat       1514
Thr Arg Thr Tyr His Asp Val Lys Glu Ile Cys Lys Cys Asp Val Asp           
        290                 295                 300                       

gaa ttt gtt att tta gag ctt gga gat ttt aat gat atc aca gaa acc       1562
Glu Phe Val Ile Leu Glu Leu Gly Asp Phe Asn Asp Ile Thr Glu Thr           
    305                 310                 315                           

tgt agc tgt tcc tgc agc tcc tct aag agt gtc act tat gag cca gac       1610
Cys Ser Cys Ser Cys Ser Ser Ser Lys Ser Val Thr Tyr Glu Pro Asp           
320                 325                 330                 335           

ttc aat tct gca gaa cta tta gcc aaa gag ctg tac cgc gtg ttc cag       1658
Phe Asn Ser Ala Glu Leu Leu Ala Lys Glu Leu Tyr Arg Val Phe Gln           
                340                 345                 350               

aag tgc tgg ata ctg tca gta gtt aat tct cag ctg gca ggt tcc ctg       1706
Lys Cys Trp Ile Leu Ser Val Val Asn Ser Gln Leu Ala Gly Ser Leu           
            355                 360                 365                   

agt gca gct ggc tcg ata gtc gta aat gaa gag tgt gtc cga aaa gac       1754
Ser Ala Ala Gly Ser Ile Val Val Asn Glu Glu Cys Val Arg Lys Asp           
        370                 375                 380                       

ttt gaa tcc agt atg aat gta gta cag gaa att aaa ttt aag tct agg       1802
Phe Glu Ser Ser Met Asn Val Val Gln Glu Ile Lys Phe Lys Ser Arg           
    385                 390                 395                           

atc aga ggg act gaa gac tgg gct cct cct aga ttt caa atc ata ttt       1850
Ile Arg Gly Thr Glu Asp Trp Ala Pro Pro Arg Phe Gln Ile Ile Phe           
400                 405                 410                 415           

aat att cat cca cca ctc aag agg gac ctt gtg gtg gca gcc cag aat       1898
Asn Ile His Pro Pro Leu Lys Arg Asp Leu Val Val Ala Ala Gln Asn           
                420                 425                 430               

ttt ttc tgt gcc ggc tgt gga act cca gta gag cct aag ttt gtg aag       1946
Phe Phe Cys Ala Gly Cys Gly Thr Pro Val Glu Pro Lys Phe Val Lys           
            435                 440                 445                   

cgg ctc cgg tac tgc gaa tac cta ggg aag tat ttc tgt gac tgc tgc       1994
Arg Leu Arg Tyr Cys Glu Tyr Leu Gly Lys Tyr Phe Cys Asp Cys Cys           
        450                 455                 460                       

cac tca tat gca gag tcg tgc atc cct gcc cga atc ctg atg atg tgg       2042
His Ser Tyr Ala Glu Ser Cys Ile Pro Ala Arg Ile Leu Met Met Trp           
    465                 470                 475                           

gac ttc aag aag tac tac gtc agc aat ttc tcc aaa cag ctg ctc gac       2090
Asp Phe Lys Lys Tyr Tyr Val Ser Asn Phe Ser Lys Gln Leu Leu Asp           
480                 485                 490                 495           

agc ata tgg cac cag ccc att ttc aat ttg ctg agc atc ggc caa agc       2138
Ser Ile Trp His Gln Pro Ile Phe Asn Leu Leu Ser Ile Gly Gln Ser           
                500                 505                 510               

ctg tat gcg aaa gcc aag gag ctg gac aga gtg aag gaa att cag gag       2186
Leu Tyr Ala Lys Ala Lys Glu Leu Asp Arg Val Lys Glu Ile Gln Glu           
            515                 520                 525                   

cag ctc ttc cat atc aag aag ctg ttg aag acc tgt agg ttt gct aac       2234
Gln Leu Phe His Ile Lys Lys Leu Leu Lys Thr Cys Arg Phe Ala Asn           
        530                 535                 540                       

agt gca tta aag gag ttc gag cag gtg ccg gga cac ttg act gat gag       2282
Ser Ala Leu Lys Glu Phe Glu Gln Val Pro Gly His Leu Thr Asp Glu           
    545                 550                 555                           

ctc cac ctg ttc tcc ctt gag gac ctg gtc agg atc aag aaa ggg ctg       2330
Leu His Leu Phe Ser Leu Glu Asp Leu Val Arg Ile Lys Lys Gly Leu           
560                 565                 570                 575           

ctg gca ccc tta ctc aag gac att ctg aaa gct tcc ctt gca cat gtg       2378
Leu Ala Pro Leu Leu Lys Asp Ile Leu Lys Ala Ser Leu Ala His Val           
                580                 585                 590               

gct ggc tgt gag ctg tgt caa gga aag ggc ttt att tgt gaa ttt tgc       2426
Ala Gly Cys Glu Leu Cys Gln Gly Lys Gly Phe Ile Cys Glu Phe Cys           
            595                 600                 605                   

cag aat acg act gtc atc ttc cca ttt cag aca gca aca tgt aga aga       2474
Gln Asn Thr Thr Val Ile Phe Pro Phe Gln Thr Ala Thr Cys Arg Arg           
        610                 615                 620                       

tgt tca gcg tgc agg gct tgc ttt cac aaa cag tgc ttc cag tcc tcc       2522
Cys Ser Ala Cys Arg Ala Cys Phe His Lys Gln Cys Phe Gln Ser Ser           
    625                 630                 635                           

gag tgc ccc cgg tgt gcg agg atc aca gcg agg aga aaa ctt ctg gaa       2570
Glu Cys Pro Arg Cys Ala Arg Ile Thr Ala Arg Arg Lys Leu Leu Glu           
640                 645                 650                 655           

agt gtg gcc tct gca gca aca tga tgcccctgag tactgtgaaa aagactgttc      2624
Ser Val Ala Ser Ala Ala Thr                                               
                660                                                       

aacatgcctt atgataacac cgatttgtgt ctattattgg tgacattgtt ttagatattg     2684

ggtattgtat attaaggaaa aagatggtct atattctctt tattgcatat acttaatgtt     2744

tcaaaagaat gcagattctg tgtttaagca cagggctgat agttgtggtt ttgtttacaa     2804

atgttctgtt ttggctgcta ttggtttttt aaagaggttt tttatacttt tgtatttgaa     2864

tagttatgtt tcactgatgc tgagccagtt tgtatgtgtg tgcatatatg tgaactgtaa     2924

ctgacaagat gaattactca gtttctcttt ctctaaagct tgtttgatga aactggttgg     2984

tcctttcagt gaacaaaaat atgaccccaa atctgtttgc tctggctttt atttcttcag     3044

gaagcagact tccacttaaa tgccattttg tgattgtgtc aatcatacac attttattta     3104

cttcagagtt tgaatagaga gtacacattt cttctgcaga tttatttcat gatgagtttg     3164

agttgcttag cagggcgtgt gggtcccgtt gaagtgcagt ttgaagcaac tgcttctaga     3224

tggcactctt tcaggtggca caaattgaac ctgtatttgt catctctgtt ccacacactg     3284

caatgtcaag ggatgcagaa gtgagtagaa ttccatccct gcccttgagg atcttgcttt     3344

aacagatgta aaactgaaca taaggtattt gcagatttaa acgaactggg ggaaataatg     3404

aacagtgtga ttctagtaat aacattaaaa tcatagacat tgactaataa ggttaaatga     3464

atcacaaaac ctttatgaat ttcttttttc taatagttct tatatgtttt cctgaaacat     3524

gtgagcctat tcttttttct tctactttct atatactttc tcccacttga gaaaggggcc     3584

ttgaggctgg gtcccttcat ggtatacctt tagactgaac ggtttgcaac ctagggcttg     3644

ggcattacat tccctgggat tcacatgccc taactaaacc taccttgatt ttctcagaca     3704

gcacaggcag gcaataaagc gtcacagatt gtcccctaac cccatccagc catgtgtatg     3764

agtgtgtttt attcaatggg atagtactga gcacatgaaa gaaatgaatg acttctgtca     3824

atctcttttc attcagtctt ctcattctgt caattgtttt ctcatccgca gtgcctctgc     3884

cagaactgtg ctcacatcca ttatttaagc cagatctttt ctaagtatta tagaagtgta     3944

gaggcacata gaataaataa aaccagactt caaaaaaaaa aaaaaaaaa                 3993


<210>  12
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Val Ser Gln Ser Thr Val Arg Gln Asp Ser Pro Val Glu Pro Trp 
1               5                   10                  15      


Glu Gly Ile Ser Asp His Ser Gly Ile Ile Asp Gly Ser Pro Arg Leu 
            20                  25                  30          


Leu Asn Thr Asp His Pro Pro Cys Gln Leu Asp Ile Arg Leu Met Arg 
        35                  40                  45              


His Lys Ala Val Trp Ile Asn Pro Gln Asp Val Gln Gln Gln Pro Gln 
    50                  55                  60                  


Asp Leu Gln Ser Gln Val Pro Ala Ala Gly Asn Ser Gly Thr His Phe 
65                  70                  75                  80  


Val Thr Asp Ala Ala Ser Pro Ser Gly Pro Ser Pro Ser Cys Leu Gly 
                85                  90                  95      


Asp Ser Leu Ala Glu Thr Thr Leu Ser Glu Asp Thr Thr Asp Ser Val 
            100                 105                 110         


Gly Ser Ala Ser Pro His Gly Ser Ser Glu Lys Ser Ser Ser Phe Ser 
        115                 120                 125             


Leu Ser Ser Thr Glu Val His Met Val Arg Pro Gly Tyr Ser His Arg 
    130                 135                 140                 


Val Ser Leu Pro Thr Ser Pro Gly Ile Leu Ala Thr Ser Pro Tyr Pro 
145                 150                 155                 160 


Glu Thr Asp Ser Ala Phe Phe Glu Pro Ser His Leu Thr Ser Ala Ala 
                165                 170                 175     


Asp Glu Gly Ala Val Gln Val Ser Arg Arg Thr Ile Ser Ser Asn Ser 
            180                 185                 190         


Phe Ser Pro Glu Val Phe Val Leu Pro Val Asp Val Glu Lys Glu Asn 
        195                 200                 205             


Ala His Phe Tyr Val Ala Asp Met Ile Ile Ser Ala Met Glu Lys Met 
    210                 215                 220                 


Lys Cys Asn Ile Leu Ser Gln Gln Gln Thr Glu Ser Trp Ser Lys Glu 
225                 230                 235                 240 


Val Ser Gly Leu Leu Gly Ser Asp Gln Pro Asp Ser Glu Met Thr Phe 
                245                 250                 255     


Asp Thr Asn Ile Lys Gln Glu Ser Gly Ser Ser Thr Ser Ser Tyr Ser 
            260                 265                 270         


Gly Tyr Glu Gly Cys Ala Val Leu Gln Val Ser Pro Val Thr Glu Thr 
        275                 280                 285             


Arg Thr Tyr His Asp Val Lys Glu Ile Cys Lys Cys Asp Val Asp Glu 
    290                 295                 300                 


Phe Val Ile Leu Glu Leu Gly Asp Phe Asn Asp Ile Thr Glu Thr Cys 
305                 310                 315                 320 


Ser Cys Ser Cys Ser Ser Ser Lys Ser Val Thr Tyr Glu Pro Asp Phe 
                325                 330                 335     


Asn Ser Ala Glu Leu Leu Ala Lys Glu Leu Tyr Arg Val Phe Gln Lys 
            340                 345                 350         


Cys Trp Ile Leu Ser Val Val Asn Ser Gln Leu Ala Gly Ser Leu Ser 
        355                 360                 365             


Ala Ala Gly Ser Ile Val Val Asn Glu Glu Cys Val Arg Lys Asp Phe 
    370                 375                 380                 


Glu Ser Ser Met Asn Val Val Gln Glu Ile Lys Phe Lys Ser Arg Ile 
385                 390                 395                 400 


Arg Gly Thr Glu Asp Trp Ala Pro Pro Arg Phe Gln Ile Ile Phe Asn 
                405                 410                 415     


Ile His Pro Pro Leu Lys Arg Asp Leu Val Val Ala Ala Gln Asn Phe 
            420                 425                 430         


Phe Cys Ala Gly Cys Gly Thr Pro Val Glu Pro Lys Phe Val Lys Arg 
        435                 440                 445             


Leu Arg Tyr Cys Glu Tyr Leu Gly Lys Tyr Phe Cys Asp Cys Cys His 
    450                 455                 460                 


Ser Tyr Ala Glu Ser Cys Ile Pro Ala Arg Ile Leu Met Met Trp Asp 
465                 470                 475                 480 


Phe Lys Lys Tyr Tyr Val Ser Asn Phe Ser Lys Gln Leu Leu Asp Ser 
                485                 490                 495     


Ile Trp His Gln Pro Ile Phe Asn Leu Leu Ser Ile Gly Gln Ser Leu 
            500                 505                 510         


Tyr Ala Lys Ala Lys Glu Leu Asp Arg Val Lys Glu Ile Gln Glu Gln 
        515                 520                 525             


Leu Phe His Ile Lys Lys Leu Leu Lys Thr Cys Arg Phe Ala Asn Ser 
    530                 535                 540                 


Ala Leu Lys Glu Phe Glu Gln Val Pro Gly His Leu Thr Asp Glu Leu 
545                 550                 555                 560 


His Leu Phe Ser Leu Glu Asp Leu Val Arg Ile Lys Lys Gly Leu Leu 
                565                 570                 575     


Ala Pro Leu Leu Lys Asp Ile Leu Lys Ala Ser Leu Ala His Val Ala 
            580                 585                 590         


Gly Cys Glu Leu Cys Gln Gly Lys Gly Phe Ile Cys Glu Phe Cys Gln 
        595                 600                 605             


Asn Thr Thr Val Ile Phe Pro Phe Gln Thr Ala Thr Cys Arg Arg Cys 
    610                 615                 620                 


Ser Ala Cys Arg Ala Cys Phe His Lys Gln Cys Phe Gln Ser Ser Glu 
625                 630                 635                 640 


Cys Pro Arg Cys Ala Arg Ile Thr Ala Arg Arg Lys Leu Leu Glu Ser 
                645                 650                 655     


Val Ala Ser Ala Ala Thr 
            660         


<210>  13
<211>  3064
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (161)..(1105)

<400>  13
aaaccatggg ggcggaagag gtgctgggca ggaggcggaa gaggtgctgt gcaggaggcg       60

ggcgggcgcg gttctttccg gaaggattga atctccttta gccccgcccg cctccgtagc      120

tgcctgaagt agtgcagggt cagcccgcaa gttgcaggtc atg gcg ctg gct gct        175
                                            Met Ala Leu Ala Ala           
                                            1               5             

cga ctg tgg cgc ctt ctg cct ttc cga cgt gga gcc gcc ccg ggg tct        223
Arg Leu Trp Arg Leu Leu Pro Phe Arg Arg Gly Ala Ala Pro Gly Ser           
                10                  15                  20                

cgt ctc cct gcg ggg act tcg ggc agc cgc ggg cat tgc ggc ccc tgt        271
Arg Leu Pro Ala Gly Thr Ser Gly Ser Arg Gly His Cys Gly Pro Cys           
            25                  30                  35                    

cga ttc cgc ggc ttc gag gta atg gga aac cca gga act ttc aaa aga        319
Arg Phe Arg Gly Phe Glu Val Met Gly Asn Pro Gly Thr Phe Lys Arg           
        40                  45                  50                        

ggc ctt tta ctc tca gct ttg tcg tat ttg ggt ttt gaa act tac cag        367
Gly Leu Leu Leu Ser Ala Leu Ser Tyr Leu Gly Phe Glu Thr Tyr Gln           
    55                  60                  65                            

gtt atc tct cag gct gct gtg gtt cat gcc aca gcc aaa gtt gaa gaa        415
Val Ile Ser Gln Ala Ala Val Val His Ala Thr Ala Lys Val Glu Glu           
70                  75                  80                  85            

ata ctt gaa caa gca gac tac ctg tat gaa agc gga gaa aca gaa aaa        463
Ile Leu Glu Gln Ala Asp Tyr Leu Tyr Glu Ser Gly Glu Thr Glu Lys           
                90                  95                  100               

ctt tat cag ttg cta acc caa tac aag gaa agt gaa gat gca gag tta        511
Leu Tyr Gln Leu Leu Thr Gln Tyr Lys Glu Ser Glu Asp Ala Glu Leu           
            105                 110                 115                   

ctg tgg cgt ttg gca cgg gca tca cgt gat gta gct cag ctt agc aga        559
Leu Trp Arg Leu Ala Arg Ala Ser Arg Asp Val Ala Gln Leu Ser Arg           
        120                 125                 130                       

acc tca gaa gag gag aaa aag cta ttg gtg tat gaa gcc cta gag tat        607
Thr Ser Glu Glu Glu Lys Lys Leu Leu Val Tyr Glu Ala Leu Glu Tyr           
    135                 140                 145                           

gca aaa aga gca cta gaa aaa aat gaa tca agt ttt gca tct cat aag        655
Ala Lys Arg Ala Leu Glu Lys Asn Glu Ser Ser Phe Ala Ser His Lys           
150                 155                 160                 165           

tgg tat gca atc tgc ctt agt gat gtt gga gat tat gaa ggc atc aag        703
Trp Tyr Ala Ile Cys Leu Ser Asp Val Gly Asp Tyr Glu Gly Ile Lys           
                170                 175                 180               

gct aaa att gca aat gca tat atc atc aag gag cat ttt gag aaa gca        751
Ala Lys Ile Ala Asn Ala Tyr Ile Ile Lys Glu His Phe Glu Lys Ala           
            185                 190                 195                   

att gaa ctg aac cct aaa gat gct act tca att cac ctt atg ggt att        799
Ile Glu Leu Asn Pro Lys Asp Ala Thr Ser Ile His Leu Met Gly Ile           
        200                 205                 210                       

tgg tgc tat aca ttt gcc gaa atg cct tgg tat caa aga aga att gct        847
Trp Cys Tyr Thr Phe Ala Glu Met Pro Trp Tyr Gln Arg Arg Ile Ala           
    215                 220                 225                           

aaa atg ctg ttt gca act cct cct agt tcc acc tat gag aag gcc tta        895
Lys Met Leu Phe Ala Thr Pro Pro Ser Ser Thr Tyr Glu Lys Ala Leu           
230                 235                 240                 245           

ggc tac ttt cac agg gca gaa caa gtg gat cca aac ttc tac agc aaa        943
Gly Tyr Phe His Arg Ala Glu Gln Val Asp Pro Asn Phe Tyr Ser Lys           
                250                 255                 260               

aac tta ctt ctt tta gga aag aca tac ttg aaa cta cac aac aaa aag        991
Asn Leu Leu Leu Leu Gly Lys Thr Tyr Leu Lys Leu His Asn Lys Lys           
            265                 270                 275                   

ctt gct gct ttc tgg cta atg aaa gcc aag gac tat cca gca cac aca       1039
Leu Ala Ala Phe Trp Leu Met Lys Ala Lys Asp Tyr Pro Ala His Thr           
        280                 285                 290                       

gag gag gat aaa cag ata cag aca gaa gct gct cag ttg ctt aca agt       1087
Glu Glu Asp Lys Gln Ile Gln Thr Glu Ala Ala Gln Leu Leu Thr Ser           
    295                 300                 305                           

ttc agt gag aag aat tga gaacttttca gagaagattt atgaaatagc              1135
Phe Ser Glu Lys Asn                                                       
310                                                                       

taataaacat tgccttttct tttaattcta aacttaatat atgaactata actgttctac     1195

ggctttttaa atgttgtgac catttaaccg tgtaaatata aaatattcta ggcttcttca     1255

caaataatag ggtaaaataa ataatcgcca taagagtggt agaaataaat ctccatggct     1315

caggcaaaga gattattttg catcctggat accagcaatg caaaatggta tgagatttct     1375

aaggattgat cacattggga tgggagatca agcaaagaaa tatttgtaga ggaggggaaa     1435

tggatctata ggggatatac agggggatgg attttcaaat tggattgatt ctaagttgaa     1495

atcttgaaga gaaggtgtgg tgacagtggt taggatgttg tgggttcctg acataaagta     1555

gttaaatgat atatcttgga gctaacctgt gtaagtaaag aactaagtaa ggagatgact     1615

aaaaatggag tagtttcctt ttttattttt ttgagacaga gtctcacttt gtttcccagg     1675

ctggtgtgca gtggcacaat ctcggcccac tgcagcctcc gcctcccggg ttcaagtgat     1735

tctcctgcct tagcctcctg agtggctggg attacagggt tgtaccacca cactcggcta     1795

acttttgtat ttttggtaga gatggggttt tgccatgttg gctaggctgg tctcaaactc     1855

ctggcctcaa gtgatctgcc cgccttggcc tcccaaattg ctgggattac aggcgtgagc     1915

caccgcacct ggccagttta ctttaaatgt ggtgtagtct catggtaaac tgaatttgtc     1975

atcagatgca aagttctatt ccctaatgga atggaaggaa cacaaaactt aagagtgaaa     2035

tggaatacta agatgttttt aaataggcag gactatgcta ctcacttgag gctggagtgc     2095

caccactgca aaatcttttt aagttttgta aaaaggagca tcttgaatcc acttagataa     2155

agacagactg tgtgtgtagg tggatttttc ccaaaggatt tgggaattgt aatgttacaa     2215

tgaactgtat ggatatgttt gtcatgtaca ttttcaaaca aaaaggaaaa ctgaaagtag     2275

tgatctttgt atacccatct cttagattca gtgattttgc tatataggtt gtgtatccct     2335

tatctgaaat acttgggact agtagaagca tcttggattt gggatgtttt tccaaatttt     2395

ggaatacctg catacacaca ataagatatc ttggagatgg gacccaagtt taaacacaaa     2455

ttcacttgtt tcatatatac cttatgcaca tagcttgaag gtaactttat ataacattat     2515

ttttaataat tttgtgcatt gagaccaagt ttgcatacct tgaaccatca gaaagcaaag     2575

gtgtcattat ctcagccact catgtgggta atttgtggtt ggttgatgtc accatcattc     2635

ctgactgaat gtatatgcta ccaataagca gttattttct tatacttatt catgcataag     2695

tacttaacag taaaaaatat gacataactc gcacaggaac aaggatggca aaaaaaaaaa     2755

tatgacacac cactgataca gtgaaaaaat aatgtggtca gggtagctag gcaacagtag     2815

catcaccaga aacctgtatc agctgttaaa cggcaacaac aatggcaggc tttcagtttc     2875

ccacttaatg atgctgtatt ttaaaaggtt attgtatact gtaattttat ttttgtaggt     2935

gaagagaaac agaagcagct gaagggccag gaagtgggtc tttctaggga tgtggcattc     2995

tgctggatgg ctttttaaaa tgggtttttt cctttaggga gaccgaataa actgtgttgt     3055

gcacctgca                                                             3064


<210>  14
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Leu Ala Ala Arg Leu Trp Arg Leu Leu Pro Phe Arg Arg Gly 
1               5                   10                  15      


Ala Ala Pro Gly Ser Arg Leu Pro Ala Gly Thr Ser Gly Ser Arg Gly 
            20                  25                  30          


His Cys Gly Pro Cys Arg Phe Arg Gly Phe Glu Val Met Gly Asn Pro 
        35                  40                  45              


Gly Thr Phe Lys Arg Gly Leu Leu Leu Ser Ala Leu Ser Tyr Leu Gly 
    50                  55                  60                  


Phe Glu Thr Tyr Gln Val Ile Ser Gln Ala Ala Val Val His Ala Thr 
65                  70                  75                  80  


Ala Lys Val Glu Glu Ile Leu Glu Gln Ala Asp Tyr Leu Tyr Glu Ser 
                85                  90                  95      


Gly Glu Thr Glu Lys Leu Tyr Gln Leu Leu Thr Gln Tyr Lys Glu Ser 
            100                 105                 110         


Glu Asp Ala Glu Leu Leu Trp Arg Leu Ala Arg Ala Ser Arg Asp Val 
        115                 120                 125             


Ala Gln Leu Ser Arg Thr Ser Glu Glu Glu Lys Lys Leu Leu Val Tyr 
    130                 135                 140                 


Glu Ala Leu Glu Tyr Ala Lys Arg Ala Leu Glu Lys Asn Glu Ser Ser 
145                 150                 155                 160 


Phe Ala Ser His Lys Trp Tyr Ala Ile Cys Leu Ser Asp Val Gly Asp 
                165                 170                 175     


Tyr Glu Gly Ile Lys Ala Lys Ile Ala Asn Ala Tyr Ile Ile Lys Glu 
            180                 185                 190         


His Phe Glu Lys Ala Ile Glu Leu Asn Pro Lys Asp Ala Thr Ser Ile 
        195                 200                 205             


His Leu Met Gly Ile Trp Cys Tyr Thr Phe Ala Glu Met Pro Trp Tyr 
    210                 215                 220                 


Gln Arg Arg Ile Ala Lys Met Leu Phe Ala Thr Pro Pro Ser Ser Thr 
225                 230                 235                 240 


Tyr Glu Lys Ala Leu Gly Tyr Phe His Arg Ala Glu Gln Val Asp Pro 
                245                 250                 255     


Asn Phe Tyr Ser Lys Asn Leu Leu Leu Leu Gly Lys Thr Tyr Leu Lys 
            260                 265                 270         


Leu His Asn Lys Lys Leu Ala Ala Phe Trp Leu Met Lys Ala Lys Asp 
        275                 280                 285             


Tyr Pro Ala His Thr Glu Glu Asp Lys Gln Ile Gln Thr Glu Ala Ala 
    290                 295                 300                 


Gln Leu Leu Thr Ser Phe Ser Glu Lys Asn 
305                 310                 


<210>  15
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  15

Glu Leu Gln Glu Lys Phe Leu Ser Leu 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  16

Glu Leu Gln Glu Lys Phe Ser Ser Leu 
1               5                   


<210>  17
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Glu Leu Asp Gly Val Phe Gln Lys Leu 
1               5                   10  


<210>  18
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  18

Gln Glu Leu Asp Arg Val Phe Gln Lys Leu 
1               5                   10  


<210>  19
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  19

Ser Leu Phe Phe Arg Lys Val Pro Phe 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  20

Ser Leu Phe Phe Arg Lys Val Ala Phe 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  21

Ser Val Leu Lys Pro Gly Asn Ser Lys 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  22

Thr Val Leu Lys Pro Gly Asn Ser Lys 
1               5                   


<210>  23
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  23

Ala Met Tyr Asp Lys Gly Pro Phe Arg Ser Lys 
1               5                   10      


<210>  24
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  24

Ala Met Tyr Asp Lys Gly Pro Phe Trp Ser Lys 
1               5                   10      


<210>  25
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  25

Arg Val Ser Leu Pro Thr Ser Pro Gly 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  26

Arg Val Ser Leu Pro Thr Ser Pro Arg 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  27

Val Met Gly Asn Pro Gly Thr Phe Lys 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  28

Val Met Gly Asn Pro Gly Thr Phe Asn 
1               5                   


