                         SEQUENCE LISTING
  
<110>  bluebird bio, Inc.
       Heffner, Garrett Collins
       Bassan, Abraham Isaac
 
<120>  COMPOUNDS FOR IMPROVED VIRAL TRANSDUCTION

<130>  BLBD-018/01WO

<150> US 61/682,068                  
<151> 2012-08-10 

<160>  18

<170>  PatentIn version 3.5

<210>  1
<211>  576
<212>  DNA
<213>  Homo sapiens

<400>  1
actcttctgg tccccacaga ctcagagaga acccaccatg gtgctgtctc ctgccgacaa       60

gaccaacgtc aaggccgcct ggggtaaggt cggcgcgcac gctggcgagt atggtgcgga      120

ggccctggag aggatgttcc tgtccttccc caccaccaag acctacttcc cgcacttcga      180

cctgagccac ggctctgccc aggttaaggg ccacggcaag aaggtggccg acgcgctgac      240

caacgccgtg gcgcacgtgg acgacatgcc caacgcgctg tccgccctga gcgacctgca      300

cgcgcacaag cttcgggtgg acccggtcaa cttcaagctc ctaagccact gcctgctggt      360

gaccctggcc gcccacctcc ccgccgagtt cacccctgcg gtgcacgcct ccctggacaa      420

gttcctggct tctgtgagca ccgtgctgac ctccaaatac cgttaagctg gagcctcggt      480

ggccatgctt cttgcccctt gggcctcccc ccagcccctc ctccccttcc tgcacccgta      540

cccccgtggt ctttgaataa agtctgagtg ggcggc                                576


<210>  2
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly 
1               5                   10                  15      


Lys Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg 
            20                  25                  30          


Met Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp 
        35                  40                  45              


Leu Ser His Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala 
    50                  55                  60                  


Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro Asn Ala 
65                  70                  75                  80  


Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro 
                85                  90                  95      


Val Asn Phe Lys Leu Leu Ser His Cys Leu Leu Val Thr Leu Ala Ala 
            100                 105                 110         


His Leu Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu Asp Lys 
        115                 120                 125             


Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg 
    130                 135                 140         


<210>  3
<211>  142
<212>  PRT
<213>  Mus musculus

<400>  3

Met Val Leu Ser Gly Glu Asp Lys Ser Asn Ile Lys Ala Ala Trp Gly 
1               5                   10                  15      


Lys Ile Gly Gly His Gly Ala Glu Tyr Gly Ala Glu Ala Leu Glu Arg 
            20                  25                  30          


Met Phe Ala Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp 
        35                  40                  45              


Val Ser His Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala 
    50                  55                  60                  


Asp Ala Leu Ala Asn Ala Ala Gly His Leu Asp Asp Leu Pro Gly Ala 
65                  70                  75                  80  


Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro 
                85                  90                  95      


Val Asn Phe Lys Leu Leu Ser His Cys Leu Leu Val Thr Leu Ala Ser 
            100                 105                 110         


His His Pro Ala Asp Phe Thr Pro Ala Val His Ala Ser Leu Asp Lys 
        115                 120                 125             


Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg 
    130                 135                 140         


<210>  4
<211>  142
<212>  PRT
<213>  Rattus norvegicus

<400>  4

Met Val Leu Ser Ala Asp Asp Lys Thr Asn Ile Lys Asn Cys Trp Gly 
1               5                   10                  15      


Lys Ile Gly Gly His Gly Gly Glu Tyr Gly Glu Glu Ala Leu Gln Arg 
            20                  25                  30          


Met Phe Ala Ala Phe Pro Thr Thr Lys Thr Tyr Phe Ser His Ile Asp 
        35                  40                  45              


Val Ser Pro Gly Ser Ala Gln Val Lys Ala His Gly Lys Lys Val Ala 
    50                  55                  60                  


Asp Ala Leu Ala Lys Ala Ala Asp His Val Glu Asp Leu Pro Gly Ala 
65                  70                  75                  80  


Leu Ser Thr Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro 
                85                  90                  95      


Val Asn Phe Lys Phe Leu Ser His Cys Leu Leu Val Thr Leu Ala Cys 
            100                 105                 110         


His His Pro Gly Asp Phe Thr Pro Ala Met His Ala Ser Leu Asp Lys 
        115                 120                 125             


Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg 
    130                 135                 140         


<210>  5
<211>  626
<212>  DNA
<213>  Homo sapiens

<400>  5
acatttgctt ctgacacaac tgtgttcact agcaacctca aacagacacc atggtgcatc       60

tgactcctga ggagaagtct gccgttactg ccctgtgggg caaggtgaac gtggatgaag      120

ttggtggtga ggccctgggc aggctgctgg tggtctaccc ttggacccag aggttctttg      180

agtcctttgg ggatctgtcc actcctgatg ctgttatggg caaccctaag gtgaaggctc      240

atggcaagaa agtgctcggt gcctttagtg atggcctggc tcacctggac aacctcaagg      300

gcacctttgc cacactgagt gagctgcact gtgacaagct gcacgtggat cctgagaact      360

tcaggctcct gggcaacgtg ctggtctgtg tgctggccca tcactttggc aaagaattca      420

ccccaccagt gcaggctgcc tatcagaaag tggtggctgg tgtggctaat gccctggccc      480

acaagtatca ctaagctcgc tttcttgctg tccaatttct attaaaggtt cctttgttcc      540

ctaagtccaa ctactaaact gggggatatt atgaagggcc ttgagcatct ggattctgcc      600

taataaaaaa catttatttt cattgc                                           626


<210>  6
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Thr Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  7
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Thr Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ala Gln Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  8
<211>  147
<212>  PRT
<213>  Mus musculus

<400>  8

Met Val His Leu Thr Asp Ala Glu Lys Ala Ala Val Ser Gly Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Ala Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Tyr Phe Asp Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Ser Ala Ser Ala Ile Met Gly Asn Ala Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Ile Thr Ala Phe Asn Asp Gly Leu Asn His Leu Asp 
65                  70                  75                  80  


Ser Leu Lys Gly Thr Phe Ala Ser Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Met Ile Val 
            100                 105                 110         


Ile Val Leu Gly His His Leu Gly Lys Asp Phe Thr Pro Ala Ala Gln 
        115                 120                 125             


Ala Ala Phe Gln Lys Val Val Ala Gly Val Ala Ala Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  9
<211>  147
<212>  PRT
<213>  Rattus norvegicus

<400>  9

Met Val His Leu Thr Asp Ala Glu Lys Ala Ala Val Asn Gly Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Pro Asp Asp Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Tyr Phe Asp Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Ser Ala Ser Ala Ile Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Ile Asn Ala Phe Asn Asp Gly Leu Lys His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ala His Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Met Ile Val 
            100                 105                 110         


Ile Val Leu Gly His His Leu Gly Lys Glu Phe Thr Pro Cys Ala Gln 
        115                 120                 125             


Ala Ala Phe Gln Lys Val Val Ala Gly Val Ala Ser Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  10
<211>  583
<212>  DNA
<213>  Homo sapiens

<400>  10
acactcgctt ctggaacgtc tgaggttatc aataagctcc tagtccagac gccatgggtc       60

atttcacaga ggaggacaag gctactatca caagcctgtg gggcaaggtg aatgtggaag      120

atgctggagg agaaaccctg ggaaggctcc tggttgtcta cccatggacc cagaggttct      180

ttgacagctt tggcaacctg tcctctgcct ctgccatcat gggcaacccc aaagtcaagg      240

cacatggcaa gaaggtgctg acttccttgg gagatgccat aaagcacctg gatgatctca      300

agggcacctt tgcccagctg agtgaactgc actgtgacaa gctgcatgtg gatcctgaga      360

acttcaagct cctgggaaat gtgctggtga ccgttttggc aatccatttc ggcaaagaat      420

tcacccctga ggtgcaggct tcctggcaga agatggtgac tggagtggcc agtgccctgt      480

cctccagata ccactgagct cactgcccat gatgcagagc tttcaaggat aggctttatt      540

ctgcaagcaa tcaaataata aatctattct gctaagagat cac                        583


<210>  11
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gly His Phe Thr Glu Glu Asp Lys Ala Thr Ile Thr Ser Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Glu Asp Ala Gly Gly Glu Thr Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Asp Ser Phe Gly Asn 
        35                  40                  45              


Leu Ser Ser Ala Ser Ala Ile Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Thr Ser Leu Gly Asp Ala Ile Lys His Leu Asp 
65                  70                  75                  80  


Asp Leu Lys Gly Thr Phe Ala Gln Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Lys Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Thr Val Leu Ala Ile His Phe Gly Lys Glu Phe Thr Pro Glu Val Gln 
        115                 120                 125             


Ala Ser Trp Gln Lys Met Val Thr Gly Val Ala Ser Ala Leu Ser Ser 
    130                 135                 140                 


Arg Tyr His 
145         


<210>  12
<211>  147
<212>  PRT
<213>  Mus musculus

<400>  12

Met Val His Phe Thr Ala Glu Glu Lys Ala Ala Ile Thr Ser Ile Trp 
1               5                   10                  15      


Asp Lys Val Asp Leu Glu Lys Val Gly Gly Glu Thr Leu Gly Arg Leu 
            20                  25                  30          


Leu Ile Val Tyr Pro Trp Thr Gln Arg Phe Phe Asp Lys Phe Gly Asn 
        35                  40                  45              


Leu Ser Ser Ala Leu Ala Ile Met Gly Asn Pro Arg Ile Arg Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Thr Ser Leu Gly Leu Gly Val Lys Asn Met Asp 
65                  70                  75                  80  


Asn Leu Lys Glu Thr Phe Ala His Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Lys Leu Leu Gly Asn Met Leu Val 
            100                 105                 110         


Ile Val Leu Ser Thr His Phe Ala Lys Glu Phe Thr Pro Glu Val Gln 
        115                 120                 125             


Ala Ala Trp Gln Lys Leu Val Ile Gly Val Ala Asn Ala Leu Ser His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  13
<211>  147
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Met Val His Phe Thr Ala Glu Glu Lys Ala Ala Ile Ile Ser Ile Trp 
1               5                   10                  15      


Glu Lys Val Asp Leu Glu Lys Ile Gly Gly Glu Thr Leu Gly Arg Leu 
            20                  25                  30          


Leu Ile Val Tyr Pro Trp Thr Gln Arg Phe Phe Asp Lys Phe Gly Asn 
        35                  40                  45              


Leu Ser Ser Ala Leu Ala Ile Met Gly Asn Pro Arg Ile Arg Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Thr Ser Leu Gly Ser Ala Val Glu Asn Met Asp 
65                  70                  75                  80  


Asn Leu Lys Glu Thr Phe Ala His Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Gln Asn Phe Lys Leu Leu Gly Asn Met Leu Val 
            100                 105                 110         


Ile Val Leu Ser Thr His Phe Ala Lys Glu Phe Thr Pro Glu Val Gln 
        115                 120                 125             


Ala Ala Trp Gln Lys Leu Val Met Gly Val Ala Asn Ala Leu Ser His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  14
<211>  774
<212>  DNA
<213>  Homo sapiens

<400>  14
agggcaagtt aagggaatag tggaatgaag gttcattttt cattctcaca aactaatgaa       60

accctgctta tcttaaacca acctgctcac tggagcaggg aggacaggac cagcataaaa      120

ggcagggcag agtcgactgt tgcttacact ttcttctgac ataacagtgt tcactagcaa      180

cctcaaacag acaccatggt gcatctgact cctgaggaga agactgctgt caatgccctg      240

tggggcaaag tgaacgtgga tgcagttggt ggtgaggccc tgggcagatt actggtggtc      300

tacccttgga cccagaggtt ctttgagtcc tttggggatc tgtcctctcc tgatgctgtt      360

atgggcaacc ctaaggtgaa ggctcatggc aagaaggtgc taggtgcctt tagtgatggc      420

ctggctcacc tggacaacct caagggcact ttttctcagc tgagtgagct gcactgtgac      480

aagctgcacg tggatcctga gaacttcagg ctcttgggca atgtgctggt gtgtgtgctg      540

gcccgcaact ttggcaagga attcacccca caaatgcagg ctgcctatca gaaggtggtg      600

gctggtgtgg ctaatgccct ggctcacaag taccattgag atcctggact gtttcctgat      660

aaccataaga agaccctatt tccctagatt ctattttctg aacttgggaa cacaatgcct      720

acttcaaggg tatggcttct gcctaataaa gaatgttcag ctcaacttcc tgat            774


<210>  15
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Val His Leu Thr Pro Glu Glu Lys Thr Ala Val Asn Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Ala Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Ser Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ser Gln Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala Arg Asn Phe Gly Lys Glu Phe Thr Pro Gln Met Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210> 16
<211> 2297
<212> DNA
<213> Homo sapiens

<400> 16
ccagccccag tccctacgcg gcagccagcc caggtgacat gccggtgctc tccaggcccc 60

ggccctggcg ggggaacacg ctgaagcgca cggccgtgct cctggccctc gcggcctatg 120

gagcccacaa agtctacccc ttggtgcgcc agtgcctggc cccggccagg ggtcttcagg 180

cgcccgccgg ggagcccacg caggaggcct ccggggtcgc ggcggccaaa gctggcatga 240

accgggtatt cctgcagcgg ctcctgtggc tcctgcggct gctgttcccc cgggtcctgt 300

gccgggagac ggggctgctg gccctgcact cggccgcctt ggtgagccgc accttcctgt 360

cggtgtatgt ggcccgcctg gacggaaggc tggcccgctg catcgtccgc aaggacccgc 420

gggcttttgg ctggcagctg ctgcagtggc tcctcatcgc cctccctgct accttcgtca 480

acagtgccat ccgttacctg gagggccaac tggccctgtc gttccgcagc cgtctggtgg 540

cccacgccta ccgcctctac ttctcccagc agacctacta ccgggtcagc aacatggacg 600

ggcggcttcg caaccctgac cagtctctga cggaggacgt ggtggccttt gcggcctctg 660

tggcccacct ctactccaac ctgaccaagc cactcctgga cgtggctgtg acttcctaca 720

ccctgcttcg ggcggcccgc tcccgtggag ccggcacagc ctggccctcg gccatcgccg 780

gcctcgtggt gttcctcacg gccaacgtgc tgcgggcctt ctcgcccaag ttcggggagc 840

tggtggcaga ggaggcgcgg cggaaggggg agctgcgcta catgcactcg cgtgtggtgg 900

ccaactcgga ggagatcgcc ttctatgggg gccatgaggt ggagctggcc ctgctacagc 960

gctcctacca ggacctggcc tcgcagatca acctcatcct tctggaacgc ctgtggtatg 1020

ttatgctgga gcagttcctc atgaagtatg tgtggagcgc ctcgggcctg ctcatggtgg 1080

ctgtccccat catcactgcc actggctact cagagtcaga tgcagaggcc gtgaagaagg 1140

cagccttgga aaagaaggag gaggagctgg tgagcgagcg cacagaagcc ttcactattg 1200

cccgcaacct cctgacagcg gctgcagatg ccattgagcg gatcatgtcg tcgtacaagg 1260

aggtgacgga gctggctggc tacacagccc gggtgcacga gatgttccag gtatttgaag 1320

atgttcagcg ctgtcacttc aagaggccca gggagctaga ggacgctcag gcggggtctg 1380

ggaccatagg ccggtctggt gtccgtgtgg agggccccct gaagatccga ggccaggtgg 1440

tggatgtgga acaggggatc atctgcgaga acatccccat cgtcacgccc tcaggagagg 1500

tggtggtggc cagcctcaac atcagggtgg aggaaggcat gcatctgctc atcacaggcc 1560

ccaatggctg cggcaagagc tccctgttcc ggatcctggg tgggctctgg cccacgtacg 1620

gtggtgtgct ctacaagccc ccaccccagc gcatgttcta catcccgcag aggccctaca 1680

tgtctgtggg ctccctgcgt gaccaggtga tctacccgga ctcagtggag gacatgcaaa 1740

ggaagggcta ctcggagcag gacctggaag ccatcctgga cgtcgtgcac ctgcaccaca 1800

tcctgcagcg ggagggaggt tgggaggcta tgtgtgactg gaaggacgtc ctgtcgggtg 1860

gcgagaagca gagaatcggc atggcccgca tgttctacca caggcccaag tacgccctcc 1920

tggatgaatg caccagcgcc gtgagcatcg acgtggaagg caagatcttc caggcggcca 1980

aggacgcggg cattgccctg ctctccatca cccaccggcc ctccctgtgg aaataccaca 2040

cacacttgct acagttcgat ggggagggcg gctggaagtt cgagaagctg gactcagctg 2100

cccgcctgag cctgacggag gagaagcagc ggctggagca gcagctggcg ggcattccca 2160

agatgcagcg gcgcctccag gagctctgcc agatcctggg cgaggccgtg gccccagcgc 2220

atgtgccggc acctagcccg caaggccctg gtggcctcca gggtgcctcc acctgactcg 2280

agggggggcc cggtacc                                                2297


<210> 17
<211> 2238
<212> DNA
<213> Homo sapiens

<400> 17
atgccggtgc tctccaggcc ccggccctgg cgggggaaca cgctgaagcg cacggccgtg 60

ctcctggccc tcgcggccta tggagcccac aaagtctacc ccttggtgcg ccagtgcctg 120

gccccggcca ggggtcttca ggcgcccgcc ggggagccca cgcaggaggc ctccggggtc 180

gcggcggcca aagctggcat gaaccgggta ttcctgcagc ggctcctgtg gctcctgcgg 240

ctgctgttcc cccgggtcct gtgccgggag acggggctgc tggccctgca ctcggccgcc 300

ttggtgagcc gcaccttcct gtcggtgtat gtggcccgcc tggacggaag gctggcccgc 360

tgcatcgtcc gcaaggaccc gcgggctttt ggctggcagc tgctgcagtg gctcctcatc 420

gccctccctg ctaccttcgt caacagtgcc atccgttacc tggagggcca actggccctg 480

tcgttccgca gccgtctggt ggcccacgcc taccgcctct acttctccca gcagacctac 540

taccgggtca gcaacatgga cgggcggctt cgcaaccctg accagtctct gacggaggac 600

gtggtggcct ttgcggcctc tgtggcccac ctctactcca acctgaccaa gccactcctg 660

gacgtggctg tgacttccta caccctgctt cgggcggccc gctcccgtgg agccggcaca 720

gcctggccct cggccatcgc cggcctcgtg gtgttcctca cggccaacgt gctgcgggcc 780

ttctcgccca agttcgggga gctggtggca gaggaggcgc ggcggaaggg ggagctgcgc 840

tacatgcact cgcgtgtggt ggccaactcg gaggagatcg ccttctatgg gggccatgag 900

gtggagctgg ccctgctaca gcgctcctac caggacctgg cctcgcagat caacctcatc 960

cttctggaac gcctgtggta tgttatgctg gagcagttcc tcatgaagta tgtgtggagc 1020

gcctcgggcc tgctcatggt ggctgtcccc atcatcactg ccactggcta ctcagagtca 1080

gatgcagagg ccgtgaagaa ggcagccttg gaaaagaagg aggaggagct ggtgagcgag 1140

cgcacagaag ccttcactat tgcccgcaac ctcctgacag cggctgcaga tgccattgag 1200

cggatcatgt cgtcgtacaa ggaggtgacg gagctggctg gctacacagc ccgggtgcac 1260

gagatgttcc aggtatttga agatgttcag cgctgtcact tcaagaggcc cagggagcta 1320

gaggacgctc aggcggggtc tgggaccata ggccggtctg gtgtccgtgt ggagggcccc 1380

ctgaagatcc gaggccaggt ggtggatgtg gaacagggga tcatctgcga gaacatcccc 1440

atcgtcacgc cctcaggaga ggtggtggtg gccagcctca acatcagggt ggaggaaggc 1500

atgcatctgc tcatcacagg ccccaatggc tgcggcaaga gctccctgtt ccggatcctg 1560

ggtgggctct ggcccacgta cggtggtgtg ctctacaagc ccccacccca gcgcatgttc 1620

tacatcccgc agaggcccta catgtctgtg ggctccctgc gtgaccaggt gatctacccg 1680

gactcagtgg aggacatgca aaggaagggc tactcggagc aggacctgga agccatcctg 1740

gacgtcgtgc acctgcacca catcctgcag cgggagggag gttgggaggc tatgtgtgac 1800

tggaaggacg tcctgtcggg tggcgagaag cagagaatcg gcatggcccg catgttctac 1860

cacaggccca agtacgccct cctggatgaa tgcaccagcg ccgtgagcat cgacgtggaa 1920

ggcaagatct tccaggcggc caaggacgcg ggcattgccc tgctctccat cacccaccgg 1980

ccctccctgt ggaaatacca cacacacttg ctacagttcg atggggaggg cggctggaag 2040

ttcgagaagc tggactcagc tgcccgcctg agcctgacgg aggagaagca gcggctggag 2100

cagcagctgg cgggcattcc caagatgcag cggcgcctcc aggagctctg ccagatcctg 2160

ggcgaggccg tggccccagc gcatgtgccg gcacctagcc cgcaaggccc tggtggcctc 2220

cagggtgcct ccacctga                                               2238


<210> 18
<211> 745
<212> PRT
<213> Homo sapiens

<400> 18

Met Pro Val Leu Ser Arg Pro Arg Pro Trp Arg Gly Asn Thr Leu Lys 
1               5                   10                  15      


Arg Thr Ala Val Leu Leu Ala Leu Ala Ala Tyr Gly Ala His Lys Val 
            20                  25                  30          


Tyr Pro Leu Val Arg Gln Cys Leu Ala Pro Ala Arg Gly Leu Gln Ala 
        35                  40                  45              


Pro Ala Gly Glu Pro Thr Gln Glu Ala Ser Gly Val Ala Ala Ala Lys 
    50                  55                  60                  


Ala Gly Met Asn Arg Val Phe Leu Gln Arg Leu Leu Trp Leu Leu Arg 
65                  70                  75                  80  


Leu Leu Phe Pro Arg Val Leu Cys Arg Glu Thr Gly Leu Leu Ala Leu 
                85                  90                  95      


His Ser Ala Ala Leu Val Ser Arg Thr Phe Leu Ser Val Tyr Val Ala 
            100                 105                 110         


Arg Leu Asp Gly Arg Leu Ala Arg Cys Ile Val Arg Lys Asp Pro Arg 
        115                 120                 125             


Ala Phe Gly Trp Gln Leu Leu Gln Trp Leu Leu Ile Ala Leu Pro Ala 
    130                 135                 140                 


Thr Phe Val Asn Ser Ala Ile Arg Tyr Leu Glu Gly Gln Leu Ala Leu 
145                 150                 155                 160 


Ser Phe Arg Ser Arg Leu Val Ala His Ala Tyr Arg Leu Tyr Phe Ser 
                165                 170                 175     


Gln Gln Thr Tyr Tyr Arg Val Ser Asn Met Asp Gly Arg Leu Arg Asn 
            180                 185                 190         


Pro Asp Gln Ser Leu Thr Glu Asp Val Val Ala Phe Ala Ala Ser Val 
        195                 200                 205             


Ala His Leu Tyr Ser Asn Leu Thr Lys Pro Leu Leu Asp Val Ala Val 
    210                 215                 220                 


Thr Ser Tyr Thr Leu Leu Arg Ala Ala Arg Ser Arg Gly Ala Gly Thr 
225                 230                 235                 240 


Ala Trp Pro Ser Ala Ile Ala Gly Leu Val Val Phe Leu Thr Ala Asn 
                245                 250                 255     


Val Leu Arg Ala Phe Ser Pro Lys Phe Gly Glu Leu Val Ala Glu Glu 
            260                 265                 270         


Ala Arg Arg Lys Gly Glu Leu Arg Tyr Met His Ser Arg Val Val Ala 
        275                 280                 285             


Asn Ser Glu Glu Ile Ala Phe Tyr Gly Gly His Glu Val Glu Leu Ala 
    290                 295                 300                 


Leu Leu Gln Arg Ser Tyr Gln Asp Leu Ala Ser Gln Ile Asn Leu Ile 
305                 310                 315                 320 


Leu Leu Glu Arg Leu Trp Tyr Val Met Leu Glu Gln Phe Leu Met Lys 
                325                 330                 335     


Tyr Val Trp Ser Ala Ser Gly Leu Leu Met Val Ala Val Pro Ile Ile 
            340                 345                 350         


Thr Ala Thr Gly Tyr Ser Glu Ser Asp Ala Glu Ala Val Lys Lys Ala 
        355                 360                 365             


Ala Leu Glu Lys Lys Glu Glu Glu Leu Val Ser Glu Arg Thr Glu Ala 
    370                 375                 380                 


Phe Thr Ile Ala Arg Asn Leu Leu Thr Ala Ala Ala Asp Ala Ile Glu 
385                 390                 395                 400 


Arg Ile Met Ser Ser Tyr Lys Glu Val Thr Glu Leu Ala Gly Tyr Thr 
                405                 410                 415     


Ala Arg Val His Glu Met Phe Gln Val Phe Glu Asp Val Gln Arg Cys 
            420                 425                 430         


His Phe Lys Arg Pro Arg Glu Leu Glu Asp Ala Gln Ala Gly Ser Gly 
        435                 440                 445             


Thr Ile Gly Arg Ser Gly Val Arg Val Glu Gly Pro Leu Lys Ile Arg 
    450                 455                 460                 


Gly Gln Val Val Asp Val Glu Gln Gly Ile Ile Cys Glu Asn Ile Pro 
465                 470                 475                 480 


Ile Val Thr Pro Ser Gly Glu Val Val Val Ala Ser Leu Asn Ile Arg 
                485                 490                 495     


Val Glu Glu Gly Met His Leu Leu Ile Thr Gly Pro Asn Gly Cys Gly 
            500                 505                 510         


Lys Ser Ser Leu Phe Arg Ile Leu Gly Gly Leu Trp Pro Thr Tyr Gly 
        515                 520                 525             


Gly Val Leu Tyr Lys Pro Pro Pro Gln Arg Met Phe Tyr Ile Pro Gln 
    530                 535                 540                 


Arg Pro Tyr Met Ser Val Gly Ser Leu Arg Asp Gln Val Ile Tyr Pro 
545                 550                 555                 560 


Asp Ser Val Glu Asp Met Gln Arg Lys Gly Tyr Ser Glu Gln Asp Leu 
                565                 570                 575     


Glu Ala Ile Leu Asp Val Val His Leu His His Ile Leu Gln Arg Glu 
            580                 585                 590         


Gly Gly Trp Glu Ala Met Cys Asp Trp Lys Asp Val Leu Ser Gly Gly 
        595                 600                 605             


Glu Lys Gln Arg Ile Gly Met Ala Arg Met Phe Tyr His Arg Pro Lys 
    610                 615                 620                 


Tyr Ala Leu Leu Asp Glu Cys Thr Ser Ala Val Ser Ile Asp Val Glu 
625                 630                 635                 640 


Gly Lys Ile Phe Gln Ala Ala Lys Asp Ala Gly Ile Ala Leu Leu Ser 
                645                 650                 655     


Ile Thr His Arg Pro Ser Leu Trp Lys Tyr His Thr His Leu Leu Gln 
            660                 665                 670         


Phe Asp Gly Glu Gly Gly Trp Lys Phe Glu Lys Leu Asp Ser Ala Ala 
        675                 680                 685             


Arg Leu Ser Leu Thr Glu Glu Lys Gln Arg Leu Glu Gln Gln Leu Ala 
    690                 695                 700                 


Gly Ile Pro Lys Met Gln Arg Arg Leu Gln Glu Leu Cys Gln Ile Leu 
705                 710                 715                 720 


Gly Glu Ala Val Ala Pro Ala His Val Pro Ala Pro Ser Pro Gln Gly 
                725                 730                 735     


Pro Gly Gly Leu Gln Gly Ala Ser Thr 
            740                 745




