                         SEQUENCE LISTING

<110>  University of Southern California
       Kahn, Michael
       Guha, Chandan
       Saha, Subhrajit
       Bhanja, Payel
 
<120>  WNT MODULATORS FOR THE PROTECTION, MITIGATION AND TREATMENT OF 
       RADIATION INJURY

<130>  0034371-049WO0

<150>  US 61/680,161
<151>  2012-08-06

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  2339
<212>  DNA
<213>  Homo sapiens

<400>  1
cgggtcgacg atttcgtcgc gccctcgccc ctcccgggcc tgcccccgtc gcgactggca       60

gcacgaagct gagattgtgg tttcctggtg attcaggtgg gagtgggcca gaagatcacc      120

gctggcaagg actggtgttt gtcaactgta aggactcatg gaacagatct accagggatt      180

ctcagacctt agtttgagaa atgctgcaat taaaggcaaa tcctatcact ctgagtgatc      240

gctttggtgt cgaggcaatc aaccataaag ataaatgcaa atatggaaat tgcataacag      300

tactcagtat taaggttggt ttttggagta gtccctgctg acgtgacaaa aagatctctc      360

atatgatatt ccgaggtatc tttgaggaag tctctctttg aggacctccc tttgagctga      420

tggagaactg ggctccccac accctctctg tccccagctg agattatggt ggatttgggc      480

tacggcccag gcctgggcct cctgctgctg acccagcccc agaggtgtta gcaagagccg      540

tgtgctatcc accctccccg agaccacccc tccgaccagg ggcctggagc tggcgcgtga      600

ctatgcggct tgggctgtgt gtggtggccc tggttctgag ctggacgcac ctcaccatca      660

gcagccgggg gatcaagggg aaaaggcaga ggcggatcag tgccgagggg agccaggcct      720

gtgccaaagg ctgtgagctc tgctctgaag tcaacggctg cctcaagtgc tcacccaagc      780

tgttcatcct gctggagagg aacgacatcc gccaggtggg cgtctgcttg ccgtcctgcc      840

cacctggata cttcgacgcc cgcaaccccg acatgaacaa gtgcatcaaa tgcaagatcg      900

agcactgtga ggcctgcttc agccataact tctgcaccaa gtgtaaggag ggcttgtacc      960

tgcacaaggg ccgctgctat ccagcttgtc ccgagggctc ctcagctgcc aatggcacca     1020

tggagtgcag tagtcctgcg caatgtgaaa tgagcgagtg gtctccgtgg gggccctgct     1080

ccaagaagca gcagctctgt ggtttccgga ggggctccga ggagcggaca cgcagggtgc     1140

tacatgcccc tgtgggggac catgctgcct gctctgacac caaggagacc cggaggtgca     1200

cagtgaggag agtgccgtgt cctgaggggc agaagaggag gaagggaggc cagggccggc     1260

gggagaatgc caacaggaac ctggccagga aggagagcaa ggaggcgggt gctggctctc     1320

gaagacgcaa ggggcagcaa cagcagcagc agcaagggac agtggggcca ctcacatctg     1380

cagggcctgc ctagggacac tgtccagcct ccaggcccat gcagaaagag ttcagtgcta     1440

ctctgcgtga ttcaagcttt cctgaactgg aacgtcgggg gcaaagcata cacacacact     1500

ccaatccatc catgcataca cagacacaag acacacacgc tcaaacccct gtccacatat     1560

acaaccatac atacttgcac atgtgtgttc atgtacacac gcagacacag acaccacaca     1620

cacacataca cacacacaca cacacgcaca cctgaggcca ccagaagaca cttccatccc     1680

tcgggcccag cagtacacac ttggtttcca gagctcccag tggacatgtc agagacaaca     1740

cttcccagca tctgagacca aactgcagag gggagccttc tggagaagct gctgggatcg     1800

gaccagccac tgtggcagat gggagccaag cttgaggact gctggtggcc tgggaagaaa     1860

ccttcttccc atcctgttca gcactcccag ctgtgtgact ttatcgttgg agagtattgt     1920

taccttccag gatacatatc agggttaacc tgactttgaa aactgcttaa aggtttattt     1980

caaattaaaa caaaaaaatc aacgacagca gtagacacag gcaccacatt cctttgcagg     2040

gtgtgagggt ttggcgaggt atgcgtagga gcaagaaggg acagggaatt tcaagagacc     2100

ccaaatagcc tgctcagtag agggtcatgc agacaaggaa gaaaacttag gggctgctct     2160

gacggtggta aacaggctgt ctatatcctt gttactcaga gcatggcccg gcagcagtgt     2220

tgtcacaggg cagcttgtta ggaatgataa tctcaggtct cattccagac ctggagagcc     2280

atgagtctaa attttaagat tcctgatgat tggcatgtta cccaaatttg agaagtgct      2339


<210>  2
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Leu Gly Leu Cys Val Val Ala Leu Val Leu Ser Trp Thr His 
1               5                   10                  15      


Leu Thr Ile Ser Ser Arg Gly Ile Lys Gly Lys Arg Gln Arg Arg Ile 
            20                  25                  30          


Ser Ala Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser 
        35                  40                  45              


Glu Val Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu 
    50                  55                  60                  


Glu Arg Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro 
65                  70                  75                  80  


Pro Gly Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile Lys 
                85                  90                  95      


Cys Lys Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys Thr 
            100                 105                 110         


Lys Cys Lys Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala 
        115                 120                 125             


Cys Pro Glu Gly Ser Ser Ala Ala Asn Gly Thr Met Glu Cys Ser Ser 
    130                 135                 140                 


Pro Ala Gln Cys Glu Met Ser Glu Trp Ser Pro Trp Gly Pro Cys Ser 
145                 150                 155                 160 


Lys Lys Gln Gln Leu Cys Gly Phe Arg Arg Gly Ser Glu Glu Arg Thr 
                165                 170                 175     


Arg Arg Val Leu His Ala Pro Val Gly Asp His Ala Ala Cys Ser Asp 
            180                 185                 190         


Thr Lys Glu Thr Arg Arg Cys Thr Val Arg Arg Val Pro Cys Pro Glu 
        195                 200                 205             


Gly Gln Lys Arg Arg Lys Gly Gly Gln Gly Arg Arg Glu Asn Ala Asn 
    210                 215                 220                 


Arg Asn Leu Ala Arg Lys Glu Ser Lys Glu Ala Gly Ala Gly Ser Arg 
225                 230                 235                 240 


Arg Arg Lys Gly Gln Gln Gln Gln Gln Gln Gln Gly Thr Val Gly Pro 
                245                 250                 255     


Leu Thr Ser Ala Gly Pro Ala 
            260             


<210>  3
<211>  3089
<212>  DNA
<213>  Homo sapiens

<400>  3
attccctccc tggtgctcgc agaggactgg cccctctccg ggctgggagc tccggccgag       60

cggaggcgcg acggagagca ccagcgcagg gcagagagcc cggagcgacc ggccagagta      120

gggcatccgc tcgggtgctg cggagaacga gggcagctcc gagccgcccc ggaggaccga      180

tgcgccgggt ggggcgctgg ccccgagggc gtgagccgtc cgcagattga gcaacttggg      240

aacgggcggg cggagcgcag gcgagccggg cgcccaggac agtcccgcag cgggcgggtg      300

agcgggccgc gccctcgccc ctcccgggcc tgcccccgtc gcgactggca gcacgaagct      360

gagattgtgg tttcctggtg attcaggtgg gagtgggcca gaagatcacc gctggcaagg      420

actggtgttt gtcaactgta aggactcatg gaacagatct accagggatt ctcagacctt      480

agtttgagaa atgctgcaat taaaggcaaa tcctatcact ctgagtgatc gctttggtgt      540

cgaggcaatc aaccataaag ataaatgcaa atatggaaat tgcataacag tactcagtat      600

taaggttggt ttttggagta gtccctgctg acgtgacaaa aagatctctc atatgatatt      660

ccgaggtatc tttgaggaag tctctctttg aggacctccc tttgagctga tggagaactg      720

ggctccccac accctctctg tccccagctg agattatggt ggatttgggc tacggcccag      780

gcctgggcct cctgctgctg acccagcccc agaggtgtta gcaagagccg tgtgctatcc      840

accctccccg agaccacccc tccgaccagg ggcctggagc tggcgcgtga ctatgcggct      900

tgggctgtgt gtggtggccc tggttctgag ctggacgcac ctcaccatca gcagccgggg      960

gatcaagggg aaaaggcaga ggcggatcag tgccgagggg agccaggcct gtgccaaagg     1020

ctgtgagctc tgctctgaag tcaacggctg cctcaagtgc tcacccaagc tgttcatcct     1080

gctggagagg aacgacatcc gccaggtggg cgtctgcttg ccgtcctgcc cacctggata     1140

cttcgacgcc cgcaaccccg acatgaacaa gtgcatcaaa tgcaagatcg agcactgtga     1200

ggcctgcttc agccataact tctgcaccaa gtgtaaggag ggcttgtacc tgcacaaggg     1260

ccgctgctat ccagcttgtc ccgagggctc ctcagctgcc aatggcacca tggagtgcag     1320

tagtcctgcg caatgtgaaa tgagcgagtg gtctccgtgg gggccctgct ccaagaagca     1380

gcagctctgt ggtttccgga ggggctccga ggagcggaca cgcagggtgc tacatgcccc     1440

tgtgggggac catgctgcct gctctgacac caaggagacc cggaggtgca cagtgaggag     1500

agtgccgtgt cctgaggggc agaagaggag gaagggaggc cagggccggc gggagaatgc     1560

caacaggaac ctggccagga aggagagcaa ggaggcgggt gctggctctc gaagacgcaa     1620

ggggcagcaa cagcagcagc agcaagggac agtggggcca ctcacatctg cagggcctgc     1680

ctagggacac tgtccagcct ccaggcccat gcagaaagag ttcagtgcta ctctgcgtga     1740

ttcaagcttt cctgaactgg aacgtcgggg gcaaagcata cacacacact ccaatccatc     1800

catgcataca tagacacaag acacacacgc tcaaacccct gtccacatat acaaccatac     1860

atacttgcac atgtgtgttc atgtacacac gcagacacag acaccacaca cacacataca     1920

cacacacaca cacacacacc tgaggccacc agaagacact tccatccctc gggcccagca     1980

gtacacactt ggtttccaga gctcccagtg gacatgtcag agacaacact tcccagcatc     2040

tgagaccaaa ctgcagaggg gagccttctg gagaagctgc tgggatcgga ccagccactg     2100

tggcagatgg gagccaagct tgaggactgc tggtgacctg ggaagaaacc ttcttcccat     2160

cctgttcagc actcccagct gtgtgacttt atcgttggag agtattgtta cccttccagg     2220

atacatatca gggttaacct gactttgaaa actgcttaaa ggtttatttc aaattaaaac     2280

aaaaaaatca acgacagcag tagacacagg caccacattc ctttgcaggg tgtgagggtt     2340

tggcgaggta tgcgtaggag caagaaggga cagggaattt caagagaccc caaatagcct     2400

gctcagtaga gggtcatgca gacaaggaag aaaacttagg ggctgctctg acggtggtaa     2460

acaggctgtc tatatccttg ttactcagag catggcccgg cagcagtgtt gtcacagggc     2520

agcttgttag gaatgagaat ctcaggtctc attccagacc tggtgagcca gagtctaaat     2580

tttaagattc ctgatgattg gcatgttacc caaatttgag aagtgctgct gtaattcccc     2640

ttaaaggacg ggagaaaggg ccccggccat cttgcagcag gagggattct ggtcagctat     2700

aaaggaggac tttccatctg ggagaggcag aatctatata ctgaagggct agtggcactg     2760

ccaggggaag ggagtgcgta ggcttccagt gatggttggg gacaatcctg cccaaaggca     2820

gggcagtgga tggaataact ccttgtggca ttctgaagtg tgtgccaggc tctggactag     2880

gtgctaggtt tccagggagg agccaaacac gggccttgct cttgtggagc ttagaggttg     2940

gtggggaaga aaataggcat gcaccaagga attgtacaaa cacatatata actacaaaag     3000

gatggtgcca agggcaggtg accactggca tctatgctta gctatgaaag tgaataaagc     3060

agaataaaaa taaaatactt tctctcagg                                       3089


<210>  4
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Leu Gly Leu Cys Val Val Ala Leu Val Leu Ser Trp Thr His 
1               5                   10                  15      


Leu Thr Ile Ser Ser Arg Gly Ile Lys Gly Lys Arg Gln Arg Arg Ile 
            20                  25                  30          


Ser Ala Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser 
        35                  40                  45              


Glu Val Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu 
    50                  55                  60                  


Glu Arg Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro 
65                  70                  75                  80  


Pro Gly Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile Lys 
                85                  90                  95      


Cys Lys Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys Thr 
            100                 105                 110         


Lys Cys Lys Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala 
        115                 120                 125             


Cys Pro Glu Gly Ser Ser Ala Ala Asn Gly Thr Met Glu Cys Ser Ser 
    130                 135                 140                 


Pro Ala Gln Cys Glu Met Ser Glu Trp Ser Pro Trp Gly Pro Cys Ser 
145                 150                 155                 160 


Lys Lys Gln Gln Leu Cys Gly Phe Arg Arg Gly Ser Glu Glu Arg Thr 
                165                 170                 175     


Arg Arg Val Leu His Ala Pro Val Gly Asp His Ala Ala Cys Ser Asp 
            180                 185                 190         


Thr Lys Glu Thr Arg Arg Cys Thr Val Arg Arg Val Pro Cys Pro Glu 
        195                 200                 205             


Gly Gln Lys Arg Arg Lys Gly Gly Gln Gly Arg Arg Glu Asn Ala Asn 
    210                 215                 220                 


Arg Asn Leu Ala Arg Lys Glu Ser Lys Glu Ala Gly Ala Gly Ser Arg 
225                 230                 235                 240 


Arg Arg Lys Gly Gln Gln Gln Gln Gln Gln Gln Gly Thr Val Gly Pro 
                245                 250                 255     


Leu Thr Ser Ala Gly Pro Ala 
            260             


<210>  5
<211>  2910
<212>  DNA
<213>  Homo sapiens

<400>  5
attccctccc tggtgctcgc agaggactgg cccctctccg ggctgggagc tccggccgag       60

cggaggcgcg acggagagca ccagcgcagg gcagagagcc cggagcgacc ggccagagta      120

gggcatccgc tcgggtgctg cggagaacga gggcagctcc gagccgcccc ggaggaccga      180

tgcgccgggt ggggcgctgg ccccgagggc gtgagccgtc cgcagattga gcaacttggg      240

aacgggcggg cggagcgcag gcgagccggg cgcccaggac agtcccgcag cgggcgggtg      300

agcgggccgc gccctcgccc ctcccgggcc tgcccccgtc gcgactggca gcacgaagct      360

gagattgtgg tttcctggtg attcaggtgg gagtgggcca gaagatcacc gctggcaagg      420

actgggttgg tttttggagt agtccctgct gacgtgacaa aaagatctct catatgatat      480

tccgaggtat ctttgaggaa gtctctcttt gaggacctcc ctttgagctg atggagaact      540

gggctcccca caccctctct gtccccagct gagattatgg tggatttggg ctacggccca      600

ggcctgggcc tcctgctgct gacccagccc cagaggtgtt agcaagagcc gtgtgctatc      660

caccctcccc gagaccaccc ctccgaccag gggcctggag ctggcgcgtg actatgcggc      720

ttgggctgtg tgtggtggcc ctggttctga gctggacgca cctcaccatc agcagccggg      780

ggatcaaggg gaaaaggcag aggcggatca gtgccgaggg gagccaggcc tgtgccaaag      840

gctgtgagct ctgctctgaa gtcaacggct gcctcaagtg ctcacccaag ctgttcatcc      900

tgctggagag gaacgacatc cgccaggtgg gcgtctgctt gccgtcctgc ccacctggat      960

acttcgacgc ccgcaacccc gacatgaaca agtgcatcaa atgcaagatc gagcactgtg     1020

aggcctgctt cagccataac ttctgcacca agtgtaagga gggcttgtac ctgcacaagg     1080

gccgctgcta tccagcttgt cccgagggct cctcagctgc caatggcacc atggagtgca     1140

gtagtcctgc gcaatgtgaa atgagcgagt ggtctccgtg ggggccctgc tccaagaagc     1200

agcagctctg tggtttccgg aggggctccg aggagcggac acgcagggtg ctacatgccc     1260

ctgtggggga ccatgctgcc tgctctgaca ccaaggagac ccggaggtgc acagtgagga     1320

gagtgccgtg tcctgagggg cagaagagga ggaagggagg ccagggccgg cgggagaatg     1380

ccaacaggaa cctggccagg aaggagagca aggaggcggg tgctggctct cgaagacgca     1440

aggggcagca acagcagcag cagcaaggga cagtggggcc actcacatct gcagggcctg     1500

cctagggaca ctgtccagcc tccaggccca tgcagaaaga gttcagtgct actctgcgtg     1560

attcaagctt tcctgaactg gaacgtcggg ggcaaagcat acacacacac tccaatccat     1620

ccatgcatac atagacacaa gacacacacg ctcaaacccc tgtccacata tacaaccata     1680

catacttgca catgtgtgtt catgtacaca cgcagacaca gacaccacac acacacatac     1740

acacacacac acacacacac ctgaggccac cagaagacac ttccatccct cgggcccagc     1800

agtacacact tggtttccag agctcccagt ggacatgtca gagacaacac ttcccagcat     1860

ctgagaccaa actgcagagg ggagccttct ggagaagctg ctgggatcgg accagccact     1920

gtggcagatg ggagccaagc ttgaggactg ctggtgacct gggaagaaac cttcttccca     1980

tcctgttcag cactcccagc tgtgtgactt tatcgttgga gagtattgtt acccttccag     2040

gatacatatc agggttaacc tgactttgaa aactgcttaa aggtttattt caaattaaaa     2100

caaaaaaatc aacgacagca gtagacacag gcaccacatt cctttgcagg gtgtgagggt     2160

ttggcgaggt atgcgtagga gcaagaaggg acagggaatt tcaagagacc ccaaatagcc     2220

tgctcagtag agggtcatgc agacaaggaa gaaaacttag gggctgctct gacggtggta     2280

aacaggctgt ctatatcctt gttactcaga gcatggcccg gcagcagtgt tgtcacaggg     2340

cagcttgtta ggaatgagaa tctcaggtct cattccagac ctggtgagcc agagtctaaa     2400

ttttaagatt cctgatgatt ggcatgttac ccaaatttga gaagtgctgc tgtaattccc     2460

cttaaaggac gggagaaagg gccccggcca tcttgcagca ggagggattc tggtcagcta     2520

taaaggagga ctttccatct gggagaggca gaatctatat actgaagggc tagtggcact     2580

gccaggggaa gggagtgcgt aggcttccag tgatggttgg ggacaatcct gcccaaaggc     2640

agggcagtgg atggaataac tccttgtggc attctgaagt gtgtgccagg ctctggacta     2700

ggtgctaggt ttccagggag gagccaaaca cgggccttgc tcttgtggag cttagaggtt     2760

ggtggggaag aaaataggca tgcaccaagg aattgtacaa acacatatat aactacaaaa     2820

ggatggtgcc aagggcaggt gaccactggc atctatgctt agctatgaaa gtgaataaag     2880

cagaataaaa ataaaatact ttctctcagg                                      2910


<210>  6
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Leu Gly Leu Cys Val Val Ala Leu Val Leu Ser Trp Thr His 
1               5                   10                  15      


Leu Thr Ile Ser Ser Arg Gly Ile Lys Gly Lys Arg Gln Arg Arg Ile 
            20                  25                  30          


Ser Ala Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser 
        35                  40                  45              


Glu Val Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu 
    50                  55                  60                  


Glu Arg Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro 
65                  70                  75                  80  


Pro Gly Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile Lys 
                85                  90                  95      


Cys Lys Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys Thr 
            100                 105                 110         


Lys Cys Lys Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala 
        115                 120                 125             


Cys Pro Glu Gly Ser Ser Ala Ala Asn Gly Thr Met Glu Cys Ser Ser 
    130                 135                 140                 


Pro Ala Gln Cys Glu Met Ser Glu Trp Ser Pro Trp Gly Pro Cys Ser 
145                 150                 155                 160 


Lys Lys Gln Gln Leu Cys Gly Phe Arg Arg Gly Ser Glu Glu Arg Thr 
                165                 170                 175     


Arg Arg Val Leu His Ala Pro Val Gly Asp His Ala Ala Cys Ser Asp 
            180                 185                 190         


Thr Lys Glu Thr Arg Arg Cys Thr Val Arg Arg Val Pro Cys Pro Glu 
        195                 200                 205             


Gly Gln Lys Arg Arg Lys Gly Gly Gln Gly Arg Arg Glu Asn Ala Asn 
    210                 215                 220                 


Arg Asn Leu Ala Arg Lys Glu Ser Lys Glu Ala Gly Ala Gly Ser Arg 
225                 230                 235                 240 


Arg Arg Lys Gly Gln Gln Gln Gln Gln Gln Gln Gly Thr Val Gly Pro 
                245                 250                 255     


Leu Thr Ser Ala Gly Pro Ala 
            260             


<210>  7
<211>  2589
<212>  DNA
<213>  Homo sapiens

<400>  7
attccctccc tggtgctcgc agaggactgg cccctctccg ggctgggagc tccggccgag       60

cggaggcgcg acggagagca ccagcgcagg gcagagagcc cggagcgacc ggccagagta      120

gggcatccgc tcgggtgctg cggagaacga gggcagctcc gagccgcccc ggaggaccga      180

tgcgccgggt ggggcgctgg ccccgagggc gtgagccgtc cgcagattga gcaacttggg      240

aacgggcggg cggagcgcag gcgagccggg cgcccaggac agtcccgcag cgggcgggtg      300

agcgggccgc gccctcgccc ctcccgggcc tgcccccgtc gcgactggca gcacgaagct      360

gagattgtgg tttcctggtg attcaggtgg gagtgggcca gaagatcacc gctggcaagg      420

actgggttgg tttttggagt agtccctgct gacgtgacaa aaagatctct catatgatat      480

tccgagtcag tgccgagggg agccaggcct gtgccaaagg ctgtgagctc tgctctgaag      540

tcaacggctg cctcaagtgc tcacccaagc tgttcatcct gctggagagg aacgacatcc      600

gccaggtggg cgtctgcttg ccgtcctgcc cacctggata cttcgacgcc cgcaaccccg      660

acatgaacaa gtgcatcaaa tgcaagatcg agcactgtga ggcctgcttc agccataact      720

tctgcaccaa gtgtaaggag ggcttgtacc tgcacaaggg ccgctgctat ccagcttgtc      780

ccgagggctc ctcagctgcc aatggcacca tggagtgcag tagtcctgcg caatgtgaaa      840

tgagcgagtg gtctccgtgg gggccctgct ccaagaagca gcagctctgt ggtttccgga      900

ggggctccga ggagcggaca cgcagggtgc tacatgcccc tgtgggggac catgctgcct      960

gctctgacac caaggagacc cggaggtgca cagtgaggag agtgccgtgt cctgaggggc     1020

agaagaggag gaagggaggc cagggccggc gggagaatgc caacaggaac ctggccagga     1080

aggagagcaa ggaggcgggt gctggctctc gaagacgcaa ggggcagcaa cagcagcagc     1140

agcaagggac agtggggcca ctcacatctg cagggcctgc ctagggacac tgtccagcct     1200

ccaggcccat gcagaaagag ttcagtgcta ctctgcgtga ttcaagcttt cctgaactgg     1260

aacgtcgggg gcaaagcata cacacacact ccaatccatc catgcataca tagacacaag     1320

acacacacgc tcaaacccct gtccacatat acaaccatac atacttgcac atgtgtgttc     1380

atgtacacac gcagacacag acaccacaca cacacataca cacacacaca cacacacacc     1440

tgaggccacc agaagacact tccatccctc gggcccagca gtacacactt ggtttccaga     1500

gctcccagtg gacatgtcag agacaacact tcccagcatc tgagaccaaa ctgcagaggg     1560

gagccttctg gagaagctgc tgggatcgga ccagccactg tggcagatgg gagccaagct     1620

tgaggactgc tggtgacctg ggaagaaacc ttcttcccat cctgttcagc actcccagct     1680

gtgtgacttt atcgttggag agtattgtta cccttccagg atacatatca gggttaacct     1740

gactttgaaa actgcttaaa ggtttatttc aaattaaaac aaaaaaatca acgacagcag     1800

tagacacagg caccacattc ctttgcaggg tgtgagggtt tggcgaggta tgcgtaggag     1860

caagaaggga cagggaattt caagagaccc caaatagcct gctcagtaga gggtcatgca     1920

gacaaggaag aaaacttagg ggctgctctg acggtggtaa acaggctgtc tatatccttg     1980

ttactcagag catggcccgg cagcagtgtt gtcacagggc agcttgttag gaatgagaat     2040

ctcaggtctc attccagacc tggtgagcca gagtctaaat tttaagattc ctgatgattg     2100

gcatgttacc caaatttgag aagtgctgct gtaattcccc ttaaaggacg ggagaaaggg     2160

ccccggccat cttgcagcag gagggattct ggtcagctat aaaggaggac tttccatctg     2220

ggagaggcag aatctatata ctgaagggct agtggcactg ccaggggaag ggagtgcgta     2280

ggcttccagt gatggttggg gacaatcctg cccaaaggca gggcagtgga tggaataact     2340

ccttgtggca ttctgaagtg tgtgccaggc tctggactag gtgctaggtt tccagggagg     2400

agccaaacac gggccttgct cttgtggagc ttagaggttg gtggggaaga aaataggcat     2460

gcaccaagga attgtacaaa cacatatata actacaaaag gatggtgcca agggcaggtg     2520

accactggca tctatgctta gctatgaaag tgaataaagc agaataaaaa taaaatactt     2580

tctctcagg                                                             2589


<210>  8
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ile Phe Arg Val Ser Ala Glu Gly Ser Gln Ala Cys Ala Lys Gly 
1               5                   10                  15      


Cys Glu Leu Cys Ser Glu Val Asn Gly Cys Leu Lys Cys Ser Pro Lys 
            20                  25                  30          


Leu Phe Ile Leu Leu Glu Arg Asn Asp Ile Arg Gln Val Gly Val Cys 
        35                  40                  45              


Leu Pro Ser Cys Pro Pro Gly Tyr Phe Asp Ala Arg Asn Pro Asp Met 
    50                  55                  60                  


Asn Lys Cys Ile Lys Cys Lys Ile Glu His Cys Glu Ala Cys Phe Ser 
65                  70                  75                  80  


His Asn Phe Cys Thr Lys Cys Lys Glu Gly Leu Tyr Leu His Lys Gly 
                85                  90                  95      


Arg Cys Tyr Pro Ala Cys Pro Glu Gly Ser Ser Ala Ala Asn Gly Thr 
            100                 105                 110         


Met Glu Cys Ser Ser Pro Ala Gln Cys Glu Met Ser Glu Trp Ser Pro 
        115                 120                 125             


Trp Gly Pro Cys Ser Lys Lys Gln Gln Leu Cys Gly Phe Arg Arg Gly 
    130                 135                 140                 


Ser Glu Glu Arg Thr Arg Arg Val Leu His Ala Pro Val Gly Asp His 
145                 150                 155                 160 


Ala Ala Cys Ser Asp Thr Lys Glu Thr Arg Arg Cys Thr Val Arg Arg 
                165                 170                 175     


Val Pro Cys Pro Glu Gly Gln Lys Arg Arg Lys Gly Gly Gln Gly Arg 
            180                 185                 190         


Arg Glu Asn Ala Asn Arg Asn Leu Ala Arg Lys Glu Ser Lys Glu Ala 
        195                 200                 205             


Gly Ala Gly Ser Arg Arg Arg Lys Gly Gln Gln Gln Gln Gln Gln Gln 
    210                 215                 220                 


Gly Thr Val Gly Pro Leu Thr Ser Ala Gly Pro Ala 
225                 230                 235     


<210>  9
<211>  2721
<212>  DNA
<213>  Homo sapiens

<400>  9
attccctccc tggtgctcgc agaggactgg cccctctccg ggctgggagc tccggccgag       60

cggaggcgcg acggagagca ccagcgcagg gcagagagcc cggagcgacc ggccagagta      120

gggcatccgc tcgggtgctg cggagaacga gggcagctcc gagccgcccc ggaggaccga      180

tgcgccgggt ggggcgctgg ccccgagggc gtgagccgtc cgcagattga gcaacttggg      240

aacgggcggg cggagcgcag gcgagccggg cgcccaggac agtcccgcag cgggcgggtg      300

agcgggccgc gccctcgccc ctcccgggcc tgcccccgtc gcgactggca gcacgaagct      360

gagattgtgg tttcctggtg attcaggtgg gagtgggcca gaagatcacc gctggcaagg      420

actgggttgg tttttggagt agtccctgct gacgtgacaa aaagatctct catatgatat      480

tccgaggtat ctttgaggaa gtctctcttt gaggacctcc ctttgagctg atggagaact      540

gggctcccca caccctctct gtccccagct gagattatgg tggatttggg ctacggccca      600

ggcctgggcc tcctgctgct gacccagccc cagaggtgtt agcaagagcc gtgtgctatc      660

caccctcccc gagaccaccc ctccgaccag gggcctggag ctggcgcgtg actatgcggc      720

ttgggctgtg tgtggtggcc ctggttctga gctggacgca cctcaccatc agcagccggg      780

ggatcaaggg gaaaaggcag aggcggatca gtgccgaggg gagccaggcc tgtgccaaag      840

gctgtgagct ctgctctgaa gtcaacggct gcctcaagtg ctcacccaag ctgttcatcc      900

tgctggagag gaacgacatc cgccaggtgg gcgtctgctt gccgtcctgc ccacctggat      960

acttcgacgc ccgcaacccc gacatgaaca agtgcatcaa atgcaagatc gagcactgtg     1020

aggcctgctt cagccataac ttctgcacca agtgtaagga gggcttgtac ctgcacaagg     1080

gccgctgcta tccagcttgt cccgagggct cctcagctgc caatggcacc atggagtgca     1140

gtagtcctgg gcagaagagg aggaagggag gccagggccg gcgggagaat gccaacagga     1200

acctggccag gaaggagagc aaggaggcgg gtgctggctc tcgaagacgc aaggggcagc     1260

aacagcagca gcagcaaggg acagtggggc cactcacatc tgcagggcct gcctagggac     1320

actgtccagc ctccaggccc atgcagaaag agttcagtgc tactctgcgt gattcaagct     1380

ttcctgaact ggaacgtcgg gggcaaagca tacacacaca ctccaatcca tccatgcata     1440

catagacaca agacacacac gctcaaaccc ctgtccacat atacaaccat acatacttgc     1500

acatgtgtgt tcatgtacac acgcagacac agacaccaca cacacacata cacacacaca     1560

cacacacaca cctgaggcca ccagaagaca cttccatccc tcgggcccag cagtacacac     1620

ttggtttcca gagctcccag tggacatgtc agagacaaca cttcccagca tctgagacca     1680

aactgcagag gggagccttc tggagaagct gctgggatcg gaccagccac tgtggcagat     1740

gggagccaag cttgaggact gctggtgacc tgggaagaaa ccttcttccc atcctgttca     1800

gcactcccag ctgtgtgact ttatcgttgg agagtattgt tacccttcca ggatacatat     1860

cagggttaac ctgactttga aaactgctta aaggtttatt tcaaattaaa acaaaaaaat     1920

caacgacagc agtagacaca ggcaccacat tcctttgcag ggtgtgaggg tttggcgagg     1980

tatgcgtagg agcaagaagg gacagggaat ttcaagagac cccaaatagc ctgctcagta     2040

gagggtcatg cagacaagga agaaaactta ggggctgctc tgacggtggt aaacaggctg     2100

tctatatcct tgttactcag agcatggccc ggcagcagtg ttgtcacagg gcagcttgtt     2160

aggaatgaga atctcaggtc tcattccaga cctggtgagc cagagtctaa attttaagat     2220

tcctgatgat tggcatgtta cccaaatttg agaagtgctg ctgtaattcc ccttaaagga     2280

cgggagaaag ggccccggcc atcttgcagc aggagggatt ctggtcagct ataaaggagg     2340

actttccatc tgggagaggc agaatctata tactgaaggg ctagtggcac tgccagggga     2400

agggagtgcg taggcttcca gtgatggttg gggacaatcc tgcccaaagg cagggcagtg     2460

gatggaataa ctccttgtgg cattctgaag tgtgtgccag gctctggact aggtgctagg     2520

tttccaggga ggagccaaac acgggccttg ctcttgtgga gcttagaggt tggtggggaa     2580

gaaaataggc atgcaccaag gaattgtaca aacacatata taactacaaa aggatggtgc     2640

caagggcagg tgaccactgg catctatgct tagctatgaa agtgaataaa gcagaataaa     2700

aataaaatac tttctctcag g                                               2721


<210>  10
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Arg Leu Gly Leu Cys Val Val Ala Leu Val Leu Ser Trp Thr His 
1               5                   10                  15      


Leu Thr Ile Ser Ser Arg Gly Ile Lys Gly Lys Arg Gln Arg Arg Ile 
            20                  25                  30          


Ser Ala Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser 
        35                  40                  45              


Glu Val Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu 
    50                  55                  60                  


Glu Arg Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro 
65                  70                  75                  80  


Pro Gly Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile Lys 
                85                  90                  95      


Cys Lys Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys Thr 
            100                 105                 110         


Lys Cys Lys Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala 
        115                 120                 125             


Cys Pro Glu Gly Ser Ser Ala Ala Asn Gly Thr Met Glu Cys Ser Ser 
    130                 135                 140                 


Pro Gly Gln Lys Arg Arg Lys Gly Gly Gln Gly Arg Arg Glu Asn Ala 
145                 150                 155                 160 


Asn Arg Asn Leu Ala Arg Lys Glu Ser Lys Glu Ala Gly Ala Gly Ser 
                165                 170                 175     


Arg Arg Arg Lys Gly Gln Gln Gln Gln Gln Gln Gln Gly Thr Val Gly 
            180                 185                 190         


Pro Leu Thr Ser Ala Gly Pro Ala 
        195                 200 


<210>  11
<211>  825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Rspo1 recombinant variant with StrepII tag (ESAWSHPQFEK)

<400>  11
atgcggcttg ggctgtgtgt ggtggccctg gttctgagct ggacgcacct caccatcagc       60

agccggggga tcaaggggaa aaggcagagg cggatcagtg ccgaggggag ccaggcctgt      120

gccaaaggct gtgagctctg ctctgaagtc aacggctgcc tcaagtgctc acccaagctg      180

ttcatcctgc tggagaggaa cgacatccgc caggtgggcg tctgcttgcc gtcctgccca      240

cctggatact tcgacgcccg caaccccgac atgaacaagt gcatcaaatg caagatcgag      300

cactgtgagg cctgcttcag ccataacttc tgcaccaagt gtaaggaggg cttgtacctg      360

cacaagggcc gctgctatcc agcttgtccc gagggctcct cagctgccaa tggcaccatg      420

gagtgcagta gtcctgcgca atgtgaaatg agcgagtggt ctccgtgggg gccctgctcc      480

aagaagcagc agctctgtgg tttccggagg ggctccgagg agcggacacg cagggtgcta      540

catgcccctg tgggggacca tgctgcctgc tctgacacca aggagacccg gaggtgcaca      600

gtgaggagag tgccgtgtcc tgaggggcag aagaggagga agggaggcca gggccggcgg      660

gagaatgcca acaggaacct ggccaggaag gagagcaagg aggcgggtgc tggctctcga      720

agacgcaagg ggcagcaaca gcagcagcag caagggacag tggggccact cacatctgca      780

gggcctgccg aaagcgcctg gagccacccc cagttcgaga agtga                      825


<210>  12
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human Rspo1 protein variant with SrepII tag (ESAWSHPQFEK) at 
       c-terminus

<400>  12

Met Arg Leu Gly Leu Cys Val Val Ala Leu Val Leu Ser Trp Thr His 
1               5                   10                  15      


Leu Thr Ile Ser Ser Arg Gly Ile Lys Gly Lys Arg Gln Arg Arg Ile 
            20                  25                  30          


Ser Ala Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser 
        35                  40                  45              


Glu Val Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu 
    50                  55                  60                  


Glu Arg Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro 
65                  70                  75                  80  


Pro Gly Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile Lys 
                85                  90                  95      


Cys Lys Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys Thr 
            100                 105                 110         


Lys Cys Lys Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala 
        115                 120                 125             


Cys Pro Glu Gly Ser Ser Ala Ala Asn Gly Thr Met Glu Cys Ser Ser 
    130                 135                 140                 


Pro Ala Gln Cys Glu Met Ser Glu Trp Ser Pro Trp Gly Pro Cys Ser 
145                 150                 155                 160 


Lys Lys Gln Gln Leu Cys Gly Phe Arg Arg Gly Ser Glu Glu Arg Thr 
                165                 170                 175     


Arg Arg Val Leu His Ala Pro Val Gly Asp His Ala Ala Cys Ser Asp 
            180                 185                 190         


Thr Lys Glu Thr Arg Arg Cys Thr Val Arg Arg Val Pro Cys Pro Glu 
        195                 200                 205             


Gly Gln Lys Arg Arg Lys Gly Gly Gln Gly Arg Arg Glu Asn Ala Asn 
    210                 215                 220                 


Arg Asn Leu Ala Arg Lys Glu Ser Lys Glu Ala Gly Ala Gly Ser Arg 
225                 230                 235                 240 


Arg Arg Lys Gly Gln Gln Gln Gln Gln Gln Gln Gly Thr Val Gly Pro 
                245                 250                 255     


Leu Thr Ser Ala Gly Pro Ala Glu Ser Ala Trp Ser His Pro Gln Phe 
            260                 265                 270         


Glu Lys 
        


