                               SEQUENCE LISTING

<110> TRUSTEES OF BOSTON UNIVERSITY
      UNIVERSITA DI PERUGIA
 
<120> PRION PROTEIN LIGANDS AS THERAPEUTIC AGENTS FOR NEURODEGENERATIVE
      DISORDERS

<130> 701586-074802-PCT

<140> PCT/US2013/053796
<141> 2013-08-06

<150> 61/679,974
<151> 2012-08-06

<150> 61/835,314
<151> 2013-06-14

<160> 9     

<170> PatentIn version 3.5

<210> 1
<211> 253
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Asn Leu Gly Cys Trp Met Leu Val Leu Phe Val Ala Thr Trp 
1               5                   10                  15      


Ser Asp Leu Gly Leu Cys Lys Lys Arg Pro Lys Pro Gly Gly Trp Asn 
            20                  25                  30          


Thr Gly Gly Ser Arg Tyr Pro Gly Gln Gly Ser Pro Gly Gly Asn Arg 
        35                  40                  45              


Tyr Pro Pro Gln Gly Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 
    50                  55                  60                  


Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 
65                  70                  75                  80  


Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Gly Gly Gly Thr His 
                85                  90                  95      


Ser Gln Trp Asn Lys Pro Ser Lys Pro Lys Thr Asn Met Lys His Met 
            100                 105                 110         


Ala Gly Ala Ala Ala Ala Gly Ala Val Val Gly Gly Leu Gly Gly Tyr 
        115                 120                 125             


Met Leu Gly Ser Ala Met Ser Arg Pro Ile Ile His Phe Gly Ser Asp 
    130                 135                 140                 


Tyr Glu Asp Arg Tyr Tyr Arg Glu Asn Met His Arg Tyr Pro Asn Gln 
145                 150                 155                 160 


Val Tyr Tyr Arg Pro Met Asp Glu Tyr Ser Asn Gln Asn Asn Phe Val 
                165                 170                 175     


His Asp Cys Val Asn Ile Thr Ile Lys Gln His Thr Val Thr Thr Thr 
            180                 185                 190         


Thr Lys Gly Glu Asn Phe Thr Glu Thr Asp Val Lys Met Met Glu Arg 
        195                 200                 205             


Val Val Glu Gln Met Cys Ile Thr Gln Tyr Glu Arg Glu Ser Gln Ala 
    210                 215                 220                 


Tyr Tyr Gln Arg Gly Ser Ser Met Val Leu Phe Ser Ser Pro Pro Val 
225                 230                 235                 240 


Ile Leu Leu Ile Ser Phe Leu Ile Phe Leu Ile Val Gly 
                245                 250             


<210> 2
<211> 220
<212> PRT
<213> Mus musculus

<400> 2
Met Ala Asn Leu Gly Tyr Trp Leu Leu Ala Leu Phe Val Thr Met Trp 
1               5                   10                  15      


Thr Asp Val Gly Leu Cys Lys Lys Arg Pro Lys Pro Gly Gly Trp Asn 
            20                  25                  30          


Thr Gly Gly Ser Arg Tyr Pro Gly Gln Gly Ser Pro Gly Gly Asn Arg 
        35                  40                  45              


Tyr Pro Pro Gln Gly Gly Thr Trp Gly Gln Pro His Gly Gly Gly Trp 
    50                  55                  60                  


Gly Gln Pro His Gly Gly Ser Trp Gly Gln Pro His Gly Gly Ser Trp 
65                  70                  75                  80  


Gly Gln Pro His Gly Gly Gly Trp Gly Gln Gly Gly Gly Thr His Asn 
                85                  90                  95      


Gln Trp Asn Lys Pro Ser Lys Pro Lys Thr Asn Leu Lys His Val Ala 
            100                 105                 110         


Gly Ala Ala Ala Ala Gly Ala Val Val Gly Gly Leu Gly Gly Tyr Met 
        115                 120                 125             


Leu Gly Ser Ala Met Ser Arg Pro Met Ile His Phe Gly Asn Asp Trp 
    130                 135                 140                 


Glu Asp Arg Tyr Tyr Arg Glu Asn Met Tyr Arg Tyr Pro Asn Gln Val 
145                 150                 155                 160 


Tyr Tyr Arg Pro Val Asp Gln Tyr Ser Asn Gln Asn Asn Phe Val His 
                165                 170                 175     


Asp Cys Val Asn Ile Thr Ile Lys Gln His Thr Val Thr Thr Thr Thr 
            180                 185                 190         


Lys Gly Glu Asn Phe Thr Glu Thr Asp Val Lys Met Met Glu Arg Val 
        195                 200                 205             


Val Glu Gln Met Cys Val Thr Gln Tyr Gln Lys Glu 
    210                 215                 220 


<210> 3
<211> 254
<212> PRT
<213> Rattus norvegicus

<400> 3
Met Ala Asn Leu Gly Tyr Trp Leu Leu Ala Leu Phe Val Thr Thr Cys 
1               5                   10                  15      


Thr Asp Val Gly Leu Cys Lys Lys Arg Pro Lys Pro Gly Gly Trp Asn 
            20                  25                  30          


Thr Gly Gly Ser Arg Tyr Pro Gly Gln Gly Ser Pro Gly Gly Asn Arg 
        35                  40                  45              


Tyr Pro Pro Gln Ser Gly Gly Thr Trp Gly Gln Pro His Gly Gly Gly 
    50                  55                  60                  


Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 
65                  70                  75                  80  


Trp Gly Gln Pro His Gly Gly Gly Trp Ser Gln Gly Gly Gly Thr His 
                85                  90                  95      


Asn Gln Trp Asn Lys Pro Ser Lys Pro Lys Thr Asn Leu Lys His Val 
            100                 105                 110         


Ala Gly Ala Ala Ala Ala Gly Ala Val Val Gly Gly Leu Gly Gly Tyr 
        115                 120                 125             


Met Leu Gly Ser Ala Met Ser Arg Pro Met Leu His Phe Gly Asn Asp 
    130                 135                 140                 


Trp Glu Asp Arg Tyr Tyr Arg Glu Asn Met Tyr Arg Tyr Pro Asn Gln 
145                 150                 155                 160 


Val Tyr Tyr Arg Pro Val Asp Gln Tyr Ser Asn Gln Asn Asn Phe Val 
                165                 170                 175     


His Asp Cys Val Asn Ile Thr Ile Lys Gln His Thr Val Thr Thr Thr 
            180                 185                 190         


Thr Lys Gly Glu Asn Phe Thr Glu Thr Asp Val Lys Met Met Glu Arg 
        195                 200                 205             


Val Val Glu Gln Met Cys Val Thr Gln Tyr Gln Lys Glu Ser Gln Ala 
    210                 215                 220                 


Tyr Tyr Asp Gly Arg Arg Ser Ser Ala Val Leu Phe Ser Ser Pro Pro 
225                 230                 235                 240 


Val Ile Leu Leu Ile Ser Phe Leu Ile Phe Leu Ile Val Gly 
                245                 250                 


<210> 4
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Met Arg Gly Ser His His His His His His 
1               5                   10  


<210> 5
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 6
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Prion 
      polybasic domain peptide

<400> 6
Lys Lys Arg Pro Lys Pro Gly Gly Trp 
1               5                   


<210> 7
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 7
His His His His His His 
1               5       


<210> 8
<211> 31
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Prion 
      polybasic domain polypeptide       

<400> 8
His Asn Gln Trp Asn Lys Pro Ser Lys Pro Lys Thr Asn Leu Lys His 
1               5                   10                  15      


Val Ala Gly Ala Ala Ala Ala Gly Ala Val Val Gly Gly Leu Gly 
            20                  25                  30      


<210> 9
<211> 4
<212> PRT
<213> Mus musculus

<400> 9
Met Ser Arg Pro 
1               


