                         

<110>  National Cheng Kung University
       Chang, Ming-shi
 
<120>  Treating Allergic Airway Disorders Using Anti-IL-20 Receptor 
       Antibodies

<130>  N0521.70012US00

<140>  TBD
<141>  2012-08-07

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  457
<212>  PRT
<213>  Mouse


<400>  1

Met Arg Val Leu Ile Leu Leu Trp Leu Phe Thr Ala Phe Pro Gly Ile 
1               5                   10                  15      


Leu Ser Val Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr 
        35                  40                  45              


Ser Asp Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Arg Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Tyr Ser Gly Ser Thr Lys Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Ile Ser Val Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Phe Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Asp Phe Gly Asp Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu 
    130                 135                 140                 


Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser 
                165                 170                 175     


Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp 
        195                 200                 205             


Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys 
225                 230                 235                 240 


Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe 
        275                 280                 285             


Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu 
    290                 295                 300                 


Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala 
                325                 330                 335     


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg 
            340                 345                 350         


Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met 
        355                 360                 365             


Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro 
    370                 375                 380                 


Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn 
385                 390                 395                 400 


Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val 
                405                 410                 415     


Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr 
            420                 425                 430         


Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu 
        435                 440                 445             


Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455         


<210>  2
<211>  1374
<212>  DNA
<213>  Mouse


<400>  2
atgagagtgc tgattctttt gtggctgttc acagcctttc ctggtatcct gtctgttgtg       60

cagcttcagg agtcgggacc tggcctggtg aaaccttctc agtctctgtc cctcacctgc      120

actgtcactg gctactcaat caccagtgat tatgcctgga actggatccg gcagtttcca      180

ggaaacagac tggagtggat gggctacata gactacagtg gtagcactaa atacaacccc      240

tctctcaaaa gtcgaatctc tgtcactcga gacacatcca agaaccagtt cttcctgcag      300

ttgaattctg tgactactga ggacacagcc acatattact gtgcaagaga ctttggtgat      360

gcttactggg gccaggggac tctggtcact gtctctgcag ccaaaacgac acccccatct      420

gtctatccac tggcccctgg atctgctgcc caaactaact ccatggtgac cctgggatgc      480

ctggtcaagg gctatttccc tgagccagtg acagtgacct ggaactctgg atccctgtcc      540

agcggtgtgc acaccttccc agctgtcctg cagtctgacc tctacactct gagcagctca      600

gtgactgtcc cctccagcac ctggcccagc gagaccgtca cctgcaacgt tgcccacccg      660

gccagcagca ccaaggtgga caagaaaatt gtgcccaggg attgtggttg taagccttgc      720

atatgtacag tcccagaagt atcatctgtc ttcatcttcc ccccaaagcc caaggatgtg      780

ctcaccatta ctctgactcc taaggtcacg tgtgttgtgg tagacatcag caaggatgat      840

cccgaggtcc agttcagctg gtttgtagat gatgtggagg tgcacacagc tcaaacgcaa      900

ccccgggagg agcagttcaa cagcactttc cgctcagtca gtgaacttcc catcatgcac      960

caggactggc tcaatggcaa ggagttcaaa tgcagggtca acagtgcagc tttccctgcc     1020

cccatcgaga aaaccatctc caaaaccaaa ggcagaccga aggctccaca ggtgtacacc     1080

attccacctc ccaaggagca aatggccaag gataaagtca gtctgacctg catgataaca     1140

gacttcttcc ctgaagacat tactgtggag tggcagtgga atgggcagcc agcggagaac     1200

tacaagaaca ctcagcccat catggacaca gatggctctt acttcgtcta cagcaagctc     1260

aatgtgcaga agagcaactg ggaggcagga aatactttca cctgctctgt gttacatgag     1320

ggcctgcaca accaccatac tgagaagagc ctctcccact ctcctggtaa atga           1374


<210>  3
<211>  240
<212>  PRT
<213>  Mouse


<400>  3

Met Asp Ser Gln Ala Gln Val Leu Met Leu Leu Leu Leu Trp Val Ser 
1               5                   10                  15      


Gly Ser Cys Gly Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Tyr Ser Arg Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Leu 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe 
    130                 135                 140                 


Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys 
145                 150                 155                 160 


Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile 
                165                 170                 175     


Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr 
        195                 200                 205             


Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His 
    210                 215                 220                 


Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 240 


<210>  4
<211>  723
<212>  DNA
<213>  Mouse


<400>  4
atggattcac aggcccaggt tcttatgtta ctgctgctat gggtatctgg ttcctgtggg       60

gacattgtga tgtcacagtc tccatcctcc ctagctgtgt cagttggaga gaaggttact      120

atgagctgca agtccagtca gagcctttta tatagtagga atcaaaagaa ctacttggcc      180

tggtaccagc tgaagccagg gcagtctcct aaactgctga tttactgggc atccactagg      240

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      300

atcagcagtg tgaaggctga agacctggca gtttattact gtcagcaata ttatagctat      360

ccgctcacgt tcggtgctgg gaccaagctg gagctgaaac gggctgatgc tgcaccaact      420

gtatccatct tcccaccatc cagtgagcag ttaacatctg gaggtgcctc agtcgtgtgc      480

ttcttgaaca acttctaccc caaagacatc aatgtcaagt ggaagattga tggcagtgaa      540

cgacaaaatg gcgtcctgaa cagttggact gatcaggaca gcaaagacag cacctacagc      600

atgagcagca ccctcacgtt gaccaaggac gagtatgaac gacataacag ctatacctgt      660

gaggccactc acaagacatc aacttcaccc attgtcaaga gcttcaacag gaatgagtgt      720

tag                                                                    723


<210>  5
<211>  460
<212>  PRT
<213>  Mouse


<400>  5

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Ala Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ala Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Asn Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Ser Ile Ser Ser Gly Gly Arg Phe Thr Ser Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Gly Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg His Asp Gly Asn Gly Gly Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val 
    130                 135                 140                 


Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr 
                165                 170                 175     


Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser 
        195                 200                 205             


Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala 
    210                 215                 220                 


Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys 
225                 230                 235                 240 


Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe 
        275                 280                 285             


Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro 
    290                 295                 300                 


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro 
305                 310                 315                 320 


Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val 
                325                 330                 335     


Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
            340                 345                 350         


Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys 
        355                 360                 365             


Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp 
    370                 375                 380                 


Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro 
385                 390                 395                 400 


Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser 
                405                 410                 415     


Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala 
            420                 425                 430         


Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
        435                 440                 445             


His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460 


<210>  6
<211>  1383
<212>  DNA
<213>  Mouse


<400>  6
atgaacttcg ggctcagcct gattttcctt gccctcattt taaaaggtgt ccagtgtgag       60

gtgcagctgg tggaggctgg gggagactta gtgaagcctg gagggtccct gaaactctcc      120

tgtgcggcct ctggattcag tttgagtaac tatggcatgt cctgggttcg ccagactcca      180

gacaagaggc tggagtgggt cgcaagcatt agtagtggtg gtcgtttcac ctcctatcca      240

gacagtgtga gggggcgatt caccatctcc agagacaatg ccaagaacac cctgtacctg      300

caaatgagcg gtctgaagtc tgaggacaca gccatgtatt actgtgcaag acacgacggc      360

aacggtgggg actactgggg tcaaggaacc tcagtcaccg tctcctcagc caaaacgaca      420

cccccatctg tctatccact ggcccctgga tctgctgccc aaactaactc catggtgacc      480

ctgggatgcc tggtcaaggg ctatttccct gagccagtga cagtgacctg gaactctgga      540

tccctgtcca gcggtgtgca caccttccca gctgtcctgc agtctgacct ctacactctg      600

agcagctcag tgactgtccc ctccagcacc tggcccagcg agaccgtcac ctgcaacgtt      660

gcccacccgg ccagcagcac caaggtggac aagaaaattg tgcccaggga ttgtggttgt      720

aagccttgca tatgtacagt cccagaagta tcatctgtct tcatcttccc cccaaagccc      780

aaggatgtgc tcaccattac tctgactcct aaggtcacgt gtgttgtggt agacatcagc      840

aaggatgatc ccgaggtcca gttcagctgg tttgtagatg atgtggaggt gcacacagct      900

cagacgcaac cccgggagga gcagttcaac agcactttcc gctcagtcag tgaacttccc      960

atcatgcacc aggactggct caatggcaag gagttcaaat gcagggtcaa cagtgcagct     1020

ttccctgccc ccatcgagaa aaccatctcc aaaaccaaag gcagaccgaa ggctccacag     1080

gtgtacacca ttccacctcc caaggagcag atggccaagg ataaagtcag tctgacctgc     1140

atgataacag acttcttccc tgaagacatt actgtggagt ggcagtggaa tgggcagcca     1200

gcggagaact acaagaacac tcagcccatc atggacacag atggctctta cttcgtctac     1260

agcaagctca atgtgcagaa gagcaactgg gaggcaggaa atactttcac ctgctctgtg     1320

ttacatgagg gcctgcacaa ccaccatact gagaagagcc tctcccactc tcctggtaaa     1380

tga                                                                   1383


<210>  7
<211>  235
<212>  PRT
<213>  Mouse


<400>  7

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Phe Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Arg 
        35                  40                  45              


Ser Ser Val Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Pro Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
    130                 135                 140                 


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
                165                 170                 175     


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
        195                 200                 205             


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
    210                 215                 220                 


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235 


<210>  8
<211>  708
<212>  DNA
<213>  Mouse


<400>  8
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcttcagt cataatgtcc       60

agaggacaaa ttgttctctc ccagtttcca gcaatcctgt ctgcatctcc aggggagaag      120

gtcacaatga cttgcagggc caggtcaagt gtaagtttca tgcactggta ccagcagaag      180

ccaggatcct cccccaaacc ctggatttat gccacatcca acctggcttc tggagtccct      240

cctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag cagagtggag      300

gctgaagatg ctgccactta ttactgccag cagtggagta gtaacccata cacgttcgga      360

ggggggacta agctggaaat aaaacgggct gatgctgcac caactgtatc catcttccca      420

ccatccagtg agcagttaac atctggaggt gcctcagtcg tgtgcttctt gaacaacttc      480

taccccaaag acatcaatgt caagtggaag attgatggca gtgaacgaca aaatggcgtc      540

ctgaacagtt ggactgatca ggacagcaaa gacagcacct acagcatgag cagcaccctc      600

acgttgacca aggacgagta tgaacgacat aacagctata cctgtgaggc cactcacaag      660

acatcaactt cacccattgt caagagcttc aacaggaatg agtgttag                   708


