                         SEQUENCE LISTING

<110>  BrainStorm Cell Therapeutics Ltd.
       Gothelf, Yael
       Levy, Yosef
       Burshtein, Alex
 
<120>  METHODS OF GENERATING MESENCHYMAL STEM CELLS WHICH SECRETE 
       NEUROTROPHIC FACTORS

<130>  56908

<150>  US 61/679,822
<151>  2012-08-06

<160>  157   

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  1
ugagcaccac acaggccggg cgc                                               23


<210>  2
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  2
uaacagucua cagccauggu cg                                                22


<210>  3
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  3
ggggcugggg ccggggccga gc                                                22


<210>  4
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  4
ggcuugcaug ggggacugg                                                    19


<210>  5
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  5
agcaggugcg gggcggcg                                                     18


<210>  6
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  6
uggcaguguc uuagcugguu gu                                                22


<210>  7
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  7
ccccagggcg acgcggcggg                                                   20


<210>  8
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  8
caaucagcaa guauacugcc cu                                                22


<210>  9
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  9
uaggcagugu cauuagcuga uug                                               23


<210>  10
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  10
cugcccuggc ccgagggacc ga                                                22


<210>  11
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  11
cggccccacg caccagggua aga                                               23


<210>  12
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  12
gggucccggg gagggggg                                                     18


<210>  13
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  13
uggcagggag gcugggaggg g                                                 21


<210>  14
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  14
uguaaacauc cuacacucag cu                                                22


<210>  15
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  15
uagcaccauu ugaaaucagu guu                                               23


<210>  16
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  16
cccaguguuu agacuaucug uuc                                               23


<210>  17
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  17
uguaaacauc cuugacugga ag                                                22


<210>  18
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  18
uucaaguaau ccaggauagg cu                                                22


<210>  19
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  19
cccugagacc cuaaccuuaa                                                   20


<210>  20
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  20
uagcagcggg aacaguucug cag                                               23


<210>  21
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  21
ugaguguugu cuacgagggc a                                                 21


<210>  22
<211>  24
<212>  RNA
<213>  Homo sapiens

<400>  22
aacaacaaaa ucacuagucu ucca                                              24


<210>  23
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  23
aaaagcuggg uugagagggc aa                                                22


<210>  24
<211>  17
<212>  RNA
<213>  Homo sapiens

<400>  24
gugggggaga ggcuguc                                                      17


<210>  25
<211>  24
<212>  RNA
<213>  Homo sapiens

<400>  25
uggguagaga aggagcucag agga                                              24


<210>  26
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  26
gaaguugccc auguuauuuu cg                                                22


<210>  27
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  27
aacauucauu gcugucggug ggu                                               23


<210>  28
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  28
cagcagcaau ucauguuuug aa                                                22


<210>  29
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  29
gggcucacau caccccau                                                     18


<210>  30
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  30
ugagugugug ugugugagug ugu                                               23


<210>  31
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  31
ugagaugaag cacuguagcu c                                                 21


<210>  32
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  32
aaaagugcuu acagugcagg uag                                               23


<210>  33
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  33
gcaguccaug ggcauauaca c                                                 21


<210>  34
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  34
uaaagugcuu auagugcagg uag                                               23


<210>  35
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  35
guccaguuuu cccaggaauc ccu                                               23


<210>  36
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  36
acugccccag gugcugcugg                                                   20


<210>  37
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  37
cagugcaaug augaaagggc au                                                22


<210>  38
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  38
uuuucaacuc uaaugggaga ga                                                22


<210>  39
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  39
uaccacaggg uagaaccacg g                                                 21


<210>  40
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  40
aaaagcuggg uugagagggc ga                                                22


<210>  41
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  41
agcuacaucu ggcuacuggg u                                                 21


<210>  42
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Leu Trp Ser Gly Cys Arg Arg Phe Gly Ala Arg Leu Gly Cys Leu 
1               5                   10                  15      


Pro Gly Gly Leu Arg Val Leu Val Gln Thr Gly His Arg Ser Leu Thr 
            20                  25                  30          


Ser Cys Ile Asp Pro Ser Met Gly Leu Asn Glu Glu Gln Lys Glu Phe 
        35                  40                  45              


Gln Lys Val Ala Phe Asp Phe Ala Ala Arg Glu Met Ala Pro Asn Met 
    50                  55                  60                  


Ala Glu Trp Asp Gln Lys Glu Leu Phe Pro Val Asp Val Met Arg Lys 
65                  70                  75                  80  


Ala Ala Gln Leu Gly Phe Gly Gly Val Tyr Ile Gln Thr Asp Val Gly 
                85                  90                  95      


Gly Ser Gly Leu Ser Arg Leu Asp Thr Ser Val Ile Phe Glu Ala Leu 
            100                 105                 110         


Ala Thr Gly Cys Thr Ser Thr Thr Ala Tyr Ile Ser Ile His Asn Met 
        115                 120                 125             


Cys Ala Trp Met Ile Asp Ser Phe Gly Asn Glu Glu Gln Arg His Lys 
    130                 135                 140                 


Phe Cys Pro Pro Leu Cys Thr Met Glu Lys Phe Ala Ser Tyr Cys Leu 
145                 150                 155                 160 


Thr Glu Pro Gly Ser Gly Ser Asp Ala Ala Ser Leu Leu Thr Ser Ala 
                165                 170                 175     


Lys Lys Gln Gly Asp His Tyr Ile Leu Asn Gly Ser Lys Ala Phe Ile 
            180                 185                 190         


Ser Gly Ala Gly Glu Ser Asp Ile Tyr Val Val Met Cys Arg Thr Gly 
        195                 200                 205             


Gly Pro Gly Pro Lys Gly Ile Ser Cys Ile Val Val Glu Lys Gly Thr 
    210                 215                 220                 


Pro Gly Leu Ser Phe Gly Lys Lys Glu Lys Lys Val Gly Trp Asn Ser 
225                 230                 235                 240 


Gln Pro Thr Arg Ala Val Ile Phe Glu Asp Cys Ala Val Pro Val Ala 
                245                 250                 255     


Asn Arg Ile Gly Ser Glu Gly Gln Gly Phe Leu Ile Ala Val Arg Gly 
            260                 265                 270         


Leu Asn Gly Gly Arg Ile Asn Ile Ala Ser Cys Ser Leu Gly Ala Ala 
        275                 280                 285             


His Ala Ser Val Ile Leu Thr Arg Asp His Leu Asn Val Arg Lys Gln 
    290                 295                 300                 


Phe Gly Glu Pro Leu Ala Ser Asn Gln Tyr Leu Gln Phe Thr Leu Ala 
305                 310                 315                 320 


Asp Met Ala Thr Arg Leu Val Ala Ala Arg Leu Met Val Arg Asn Ala 
                325                 330                 335     


Ala Val Ala Leu Gln Glu Glu Arg Lys Asp Ala Val Ala Leu Cys Ser 
            340                 345                 350         


Met Ala Lys Leu Phe Ala Thr Asp Glu Cys Phe Ala Ile Cys Asn Gln 
        355                 360                 365             


Ala Leu Gln Met His Gly Gly Tyr Gly Tyr Leu Lys Asp Tyr Ala Val 
    370                 375                 380                 


Gln Gln Tyr Val Arg Asp Ser Arg Val His Gln Ile Leu Glu Gly Ser 
385                 390                 395                 400 


Asn Glu Val Met Arg Ile Leu Ile Ser Arg Ser Leu Leu Gln Glu 
                405                 410                 415 


<210>  43
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ser Leu Pro Ser Ser Arg Ala Ala Arg Val Pro Gly Pro Ser Gly 
1               5                   10                  15      


Ser Leu Cys Ala Leu Leu Ala Leu Leu Leu Leu Leu Thr Pro Pro Gly 
            20                  25                  30          


Pro Leu Ala Ser Ala Gly Pro Val Ser Ala Val Leu Thr Glu Leu Arg 
        35                  40                  45              


Cys Thr Cys Leu Arg Val Thr Leu Arg Val Asn Pro Lys Thr Ile Gly 
    50                  55                  60                  


Lys Leu Gln Val Phe Pro Ala Gly Pro Gln Cys Ser Lys Val Glu Val 
65                  70                  75                  80  


Val Ala Ser Leu Lys Asn Gly Lys Gln Val Cys Leu Asp Pro Glu Ala 
                85                  90                  95      


Pro Phe Leu Lys Lys Val Ile Gln Lys Ile Leu Asp Ser Gly Asn Lys 
            100                 105                 110         


Lys Asn 
        


<210>  44
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Leu Cys Cys Met Arg Arg Thr Lys Gln Val Glu Lys Asn Asp Asp 
1               5                   10                  15      


Asp Gln Lys Ile Glu Gln Asp Gly Ile Lys Pro Glu Asp Lys Ala His 
            20                  25                  30          


Lys Ala Ala Thr Lys Ile Gln Ala Ser Phe Arg Gly His Ile Thr Arg 
        35                  40                  45              


Lys Lys Leu Lys Gly Glu Lys Lys Asp Asp Val Gln Ala Ala Glu Ala 
    50                  55                  60                  


Glu Ala Asn Lys Lys Asp Glu Ala Pro Val Ala Asp Gly Val Glu Lys 
65                  70                  75                  80  


Lys Gly Glu Gly Thr Thr Thr Ala Glu Ala Ala Pro Ala Thr Gly Ser 
                85                  90                  95      


Lys Pro Asp Glu Pro Gly Lys Ala Gly Glu Thr Pro Ser Glu Glu Lys 
            100                 105                 110         


Lys Gly Glu Gly Asp Ala Ala Thr Glu Gln Ala Ala Pro Gln Ala Pro 
        115                 120                 125             


Ala Ser Ser Glu Glu Lys Ala Gly Ser Ala Glu Thr Glu Ser Ala Thr 
    130                 135                 140                 


Lys Ala Ser Thr Asp Asn Ser Pro Ser Ser Lys Ala Glu Asp Ala Pro 
145                 150                 155                 160 


Ala Lys Glu Glu Pro Lys Gln Ala Asp Val Pro Ala Ala Val Thr Ala 
                165                 170                 175     


Ala Ala Ala Thr Thr Pro Ala Ala Glu Asp Ala Ala Ala Lys Ala Thr 
            180                 185                 190         


Ala Gln Pro Pro Thr Glu Thr Gly Glu Ser Ser Gln Ala Glu Glu Asn 
        195                 200                 205             


Ile Glu Ala Val Asp Glu Thr Lys Pro Lys Glu Ser Ala Arg Gln Asp 
    210                 215                 220                 


Glu Gly Lys Glu Glu Glu Pro Glu Ala Asp Gln Glu His Ala 
225                 230                 235             


<210>  45
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Pro Gly Gln Glu Leu Arg Thr Val Asn Gly Ser Gln Met Leu Leu 
1               5                   10                  15      


Val Leu Leu Val Leu Ser Trp Leu Pro His Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Glu Ala Ser Arg Ala Ser Phe Pro Gly Pro Ser Glu Leu His Ser 
        35                  40                  45              


Glu Asp Ser Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp Leu Leu 
    50                  55                  60                  


Thr Arg Leu Arg Ala Asn Gln Ser Trp Glu Asp Ser Asn Thr Asp Leu 
65                  70                  75                  80  


Val Pro Ala Pro Ala Val Arg Ile Leu Thr Pro Glu Val Arg Leu Gly 
                85                  90                  95      


Ser Gly Gly His Leu His Leu Arg Ile Ser Arg Ala Ala Leu Pro Glu 
            100                 105                 110         


Gly Leu Pro Glu Ala Ser Arg Leu His Arg Ala Leu Phe Arg Leu Ser 
        115                 120                 125             


Pro Thr Ala Ser Arg Ser Trp Asp Val Thr Arg Pro Leu Arg Arg Gln 
    130                 135                 140                 


Leu Ser Leu Ala Arg Pro Gln Ala Pro Ala Leu His Leu Arg Leu Ser 
145                 150                 155                 160 


Pro Pro Pro Ser Gln Ser Asp Gln Leu Leu Ala Glu Ser Ser Ser Ala 
                165                 170                 175     


Arg Pro Gln Leu Glu Leu His Leu Arg Pro Gln Ala Ala Arg Gly Arg 
            180                 185                 190         


Arg Arg Ala Arg Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly 
        195                 200                 205             


Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly 
    210                 215                 220                 


Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys 
225                 230                 235                 240 


Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln 
                245                 250                 255     


Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro 
            260                 265                 270         


Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr 
        275                 280                 285             


Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Ile 
305             


<210>  46
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Arg Gln Gln Asp Ala Pro Lys Pro Thr Pro Ala Ala Cys Arg Cys 
1               5                   10                  15      


Ser Gly Leu Ala Arg Arg Val Leu Thr Ile Ala Phe Ala Leu Leu Ile 
            20                  25                  30          


Leu Gly Leu Met Thr Trp Ala Tyr Ala Ala Gly Val Pro Leu Ala Ser 
        35                  40                  45              


Asp Arg Tyr Gly Leu Leu Ala Phe Gly Leu Tyr Gly Ala Phe Leu Ser 
    50                  55                  60                  


Ala His Leu Val Ala Gln Ser Leu Phe Ala Tyr Leu Glu His Arg Arg 
65                  70                  75                  80  


Val Ala Ala Ala Ala Arg Gly Pro Leu Asp Ala Ala Thr Ala Arg Ser 
                85                  90                  95      


Val Ala Leu Thr Ile Ser Ala Tyr Gln Glu Asp Pro Ala Tyr Leu Arg 
            100                 105                 110         


Gln Cys Leu Ala Ser Ala Arg Ala Leu Leu Tyr Pro Arg Ala Arg Leu 
        115                 120                 125             


Arg Val Leu Met Val Val Asp Gly Asn Arg Ala Glu Asp Leu Tyr Met 
    130                 135                 140                 


Val Asp Met Phe Arg Glu Val Phe Ala Asp Glu Asp Pro Ala Thr Tyr 
145                 150                 155                 160 


Val Trp Asp Gly Asn Tyr His Gln Pro Trp Glu Pro Ala Ala Ala Gly 
                165                 170                 175     


Ala Val Gly Ala Gly Ala Tyr Arg Glu Val Glu Ala Glu Asp Pro Gly 
            180                 185                 190         


Arg Leu Ala Val Glu Ala Leu Val Arg Thr Arg Arg Cys Val Cys Val 
        195                 200                 205             


Ala Gln Arg Trp Gly Gly Lys Arg Glu Val Met Tyr Thr Ala Phe Lys 
    210                 215                 220                 


Ala Leu Gly Asp Ser Val Asp Tyr Val Gln Val Cys Asp Ser Asp Thr 
225                 230                 235                 240 


Arg Leu Asp Pro Met Ala Leu Leu Glu Leu Val Arg Val Leu Asp Glu 
                245                 250                 255     


Asp Pro Arg Val Gly Ala Val Gly Gly Asp Val Arg Ile Leu Asn Pro 
            260                 265                 270         


Leu Asp Ser Trp Val Ser Phe Leu Ser Ser Leu Arg Tyr Trp Val Ala 
        275                 280                 285             


Phe Asn Val Glu Arg Ala Cys Gln Ser Tyr Phe His Cys Val Ser Cys 
    290                 295                 300                 


Ile Ser Gly Pro Leu Gly Leu Tyr Arg Asn Asn Leu Leu Gln Gln Phe 
305                 310                 315                 320 


Leu Glu Ala Trp Tyr Asn Gln Lys Phe Leu Gly Thr His Cys Thr Phe 
                325                 330                 335     


Gly Asp Asp Arg His Leu Thr Asn Arg Met Leu Ser Met Gly Tyr Ala 
            340                 345                 350         


Thr Lys Tyr Thr Ser Arg Ser Arg Cys Tyr Ser Glu Thr Pro Ser Ser 
        355                 360                 365             


Phe Leu Arg Trp Leu Ser Gln Gln Thr Arg Trp Ser Lys Ser Tyr Phe 
    370                 375                 380                 


Arg Glu Trp Leu Tyr Asn Ala Leu Trp Trp His Arg His His Ala Trp 
385                 390                 395                 400 


Met Thr Tyr Glu Ala Val Val Ser Gly Leu Phe Pro Phe Phe Val Ala 
                405                 410                 415     


Ala Thr Val Leu Arg Leu Phe Tyr Ala Gly Arg Pro Trp Ala Leu Leu 
            420                 425                 430         


Trp Val Leu Leu Cys Val Gln Gly Val Ala Leu Ala Lys Ala Ala Phe 
        435                 440                 445             


Ala Ala Trp Leu Arg Gly Cys Leu Arg Met Val Leu Leu Ser Leu Tyr 
    450                 455                 460                 


Ala Pro Leu Tyr Met Cys Gly Leu Leu Pro Ala Lys Phe Leu Ala Leu 
465                 470                 475                 480 


Val Thr Met Asn Gln Ser Gly Trp Gly Thr Ser Gly Arg Arg Lys Leu 
                485                 490                 495     


Ala Ala Asn Tyr Val Pro Leu Leu Pro Leu Ala Leu Trp Ala Leu Leu 
            500                 505                 510         


Leu Leu Gly Gly Leu Val Arg Ser Val Ala His Glu Ala Arg Ala Asp 
        515                 520                 525             


Trp Ser Gly Pro Ser Arg Ala Ala Glu Ala Tyr His Leu Ala Ala Gly 
    530                 535                 540                 


Ala Gly Ala Tyr Val Gly Tyr Trp Val Ala Met Leu Thr Leu Tyr Trp 
545                 550                 555                 560 


Val Gly Val Arg Arg Leu Cys Arg Arg Arg Thr Gly Gly Tyr Arg Val 
                565                 570                 575     


Gln Val 
        


<210>  47
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         


Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 


Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     


Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 


<210>  48
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Thr Ser Lys Leu Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser 
1               5                   10                  15      


Ala Ala Leu Cys Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu 
            20                  25                  30          


Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe 
        35                  40                  45              


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr 
    50                  55                  60                  


Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro 
65                  70                  75                  80  


Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala 
                85                  90                  95      


Glu Asn Ser 
            


<210>  49
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Pro Leu Leu Trp Leu Arg Gly Phe Leu Leu Ala Ser Cys Trp Ile 
1               5                   10                  15      


Ile Val Arg Ser Ser Pro Thr Pro Gly Ser Glu Gly His Ser Ala Ala 
            20                  25                  30          


Pro Asp Cys Pro Ser Cys Ala Leu Ala Ala Leu Pro Lys Asp Val Pro 
        35                  40                  45              


Asn Ser Gln Pro Glu Met Val Glu Ala Val Lys Lys His Ile Leu Asn 
    50                  55                  60                  


Met Leu His Leu Lys Lys Arg Pro Asp Val Thr Gln Pro Val Pro Lys 
65                  70                  75                  80  


Ala Ala Leu Leu Asn Ala Ile Arg Lys Leu His Val Gly Lys Val Gly 
                85                  90                  95      


Glu Asn Gly Tyr Val Glu Ile Glu Asp Asp Ile Gly Arg Arg Ala Glu 
            100                 105                 110         


Met Asn Glu Leu Met Glu Gln Thr Ser Glu Ile Ile Thr Phe Ala Glu 
        115                 120                 125             


Ser Gly Thr Ala Arg Lys Thr Leu His Phe Glu Ile Ser Lys Glu Gly 
    130                 135                 140                 


Ser Asp Leu Ser Val Val Glu Arg Ala Glu Val Trp Leu Phe Leu Lys 
145                 150                 155                 160 


Val Pro Lys Ala Asn Arg Thr Arg Thr Lys Val Thr Ile Arg Leu Phe 
                165                 170                 175     


Gln Gln Gln Lys His Pro Gln Gly Ser Leu Asp Thr Gly Glu Glu Ala 
            180                 185                 190         


Glu Glu Val Gly Leu Lys Gly Glu Arg Ser Glu Leu Leu Leu Ser Glu 
        195                 200                 205             


Lys Val Val Asp Ala Arg Lys Ser Thr Trp His Val Phe Pro Val Ser 
    210                 215                 220                 


Ser Ser Ile Gln Arg Leu Leu Asp Gln Gly Lys Ser Ser Leu Asp Val 
225                 230                 235                 240 


Arg Ile Ala Cys Glu Gln Cys Gln Glu Ser Gly Ala Ser Leu Val Leu 
                245                 250                 255     


Leu Gly Lys Lys Lys Lys Lys Glu Glu Glu Gly Glu Gly Lys Lys Lys 
            260                 265                 270         


Gly Gly Gly Glu Gly Gly Ala Gly Ala Asp Glu Glu Lys Glu Gln Ser 
        275                 280                 285             


His Arg Pro Phe Leu Met Leu Gln Ala Arg Gln Ser Glu Asp His Pro 
    290                 295                 300                 


His Arg Arg Arg Arg Arg Gly Leu Glu Cys Asp Gly Lys Val Asn Ile 
305                 310                 315                 320 


Cys Cys Lys Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn 
                325                 330                 335     


Asp Trp Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly 
            340                 345                 350         


Glu Cys Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe 
        355                 360                 365             


His Ser Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe 
    370                 375                 380                 


Ala Asn Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser 
385                 390                 395                 400 


Met Leu Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln 
                405                 410                 415     


Asn Met Ile Val Glu Glu Cys Gly Cys Ser 
            420                 425     


<210>  50
<211>  1242
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ala Ser Pro Pro Glu Ser Asp Gly Phe Ser Asp Val Arg Lys Val 
1               5                   10                  15      


Gly Tyr Leu Arg Lys Pro Lys Ser Met His Lys Arg Phe Phe Val Leu 
            20                  25                  30          


Arg Ala Ala Ser Glu Ala Gly Gly Pro Ala Arg Leu Glu Tyr Tyr Glu 
        35                  40                  45              


Asn Glu Lys Lys Trp Arg His Lys Ser Ser Ala Pro Lys Arg Ser Ile 
    50                  55                  60                  


Pro Leu Glu Ser Cys Phe Asn Ile Asn Lys Arg Ala Asp Ser Lys Asn 
65                  70                  75                  80  


Lys His Leu Val Ala Leu Tyr Thr Arg Asp Glu His Phe Ala Ile Ala 
                85                  90                  95      


Ala Asp Ser Glu Ala Glu Gln Asp Ser Trp Tyr Gln Ala Leu Leu Gln 
            100                 105                 110         


Leu His Asn Arg Ala Lys Gly His His Asp Gly Ala Ala Ala Leu Gly 
        115                 120                 125             


Ala Gly Gly Gly Gly Gly Ser Cys Ser Gly Ser Ser Gly Leu Gly Glu 
    130                 135                 140                 


Ala Gly Glu Asp Leu Ser Tyr Gly Asp Val Pro Pro Gly Pro Ala Phe 
145                 150                 155                 160 


Lys Glu Val Trp Gln Val Ile Leu Lys Pro Lys Gly Leu Gly Gln Thr 
                165                 170                 175     


Lys Asn Leu Ile Gly Ile Tyr Arg Leu Cys Leu Thr Ser Lys Thr Ile 
            180                 185                 190         


Ser Phe Val Lys Leu Asn Ser Glu Ala Ala Ala Val Val Leu Gln Leu 
        195                 200                 205             


Met Asn Ile Arg Arg Cys Gly His Ser Glu Asn Phe Phe Phe Ile Glu 
    210                 215                 220                 


Val Gly Arg Ser Ala Val Thr Gly Pro Gly Glu Phe Trp Met Gln Val 
225                 230                 235                 240 


Asp Asp Ser Val Val Ala Gln Asn Met His Glu Thr Ile Leu Glu Ala 
                245                 250                 255     


Met Arg Ala Met Ser Asp Glu Phe Arg Pro Arg Ser Lys Ser Gln Ser 
            260                 265                 270         


Ser Ser Asn Cys Ser Asn Pro Ile Ser Val Pro Leu Arg Arg His His 
        275                 280                 285             


Leu Asn Asn Pro Pro Pro Ser Gln Val Gly Leu Thr Arg Arg Ser Arg 
    290                 295                 300                 


Thr Glu Ser Ile Thr Ala Thr Ser Pro Ala Ser Met Val Gly Gly Lys 
305                 310                 315                 320 


Pro Gly Ser Phe Arg Val Arg Ala Ser Ser Asp Gly Glu Gly Thr Met 
                325                 330                 335     


Ser Arg Pro Ala Ser Val Asp Gly Ser Pro Val Ser Pro Ser Thr Asn 
            340                 345                 350         


Arg Thr His Ala His Arg His Arg Gly Ser Ala Arg Leu His Pro Pro 
        355                 360                 365             


Leu Asn His Ser Arg Ser Ile Pro Met Pro Ala Ser Arg Cys Ser Pro 
    370                 375                 380                 


Ser Ala Thr Ser Pro Val Ser Leu Ser Ser Ser Ser Thr Ser Gly His 
385                 390                 395                 400 


Gly Ser Thr Ser Asp Cys Leu Phe Pro Arg Arg Ser Ser Ala Ser Val 
                405                 410                 415     


Ser Gly Ser Pro Ser Asp Gly Gly Phe Ile Ser Ser Asp Glu Tyr Gly 
            420                 425                 430         


Ser Ser Pro Cys Asp Phe Arg Ser Ser Phe Arg Ser Val Thr Pro Asp 
        435                 440                 445             


Ser Leu Gly His Thr Pro Pro Ala Arg Gly Glu Glu Glu Leu Ser Asn 
    450                 455                 460                 


Tyr Ile Cys Met Gly Gly Lys Gly Pro Ser Thr Leu Thr Ala Pro Asn 
465                 470                 475                 480 


Gly His Tyr Ile Leu Ser Arg Gly Gly Asn Gly His Arg Cys Thr Pro 
                485                 490                 495     


Gly Thr Gly Leu Gly Thr Ser Pro Ala Leu Ala Gly Asp Glu Ala Ala 
            500                 505                 510         


Ser Ala Ala Asp Leu Asp Asn Arg Phe Arg Lys Arg Thr His Ser Ala 
        515                 520                 525             


Gly Thr Ser Pro Thr Ile Thr His Gln Lys Thr Pro Ser Gln Ser Ser 
    530                 535                 540                 


Val Ala Ser Ile Glu Glu Tyr Thr Glu Met Met Pro Ala Tyr Pro Pro 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Arg Leu Pro Gly His Arg His Ser Ala Phe 
                565                 570                 575     


Val Pro Thr Arg Ser Tyr Pro Glu Glu Gly Leu Glu Met His Pro Leu 
            580                 585                 590         


Glu Arg Arg Gly Gly His His Arg Pro Asp Ser Ser Thr Leu His Thr 
        595                 600                 605             


Asp Asp Gly Tyr Met Pro Met Ser Pro Gly Val Ala Pro Val Pro Ser 
    610                 615                 620                 


Gly Arg Lys Gly Ser Gly Asp Tyr Met Pro Met Ser Pro Lys Ser Val 
625                 630                 635                 640 


Ser Ala Pro Gln Gln Ile Ile Asn Pro Ile Arg Arg His Pro Gln Arg 
                645                 650                 655     


Val Asp Pro Asn Gly Tyr Met Met Met Ser Pro Ser Gly Gly Cys Ser 
            660                 665                 670         


Pro Asp Ile Gly Gly Gly Pro Ser Ser Ser Ser Ser Ser Ser Asn Ala 
        675                 680                 685             


Val Pro Ser Gly Thr Ser Tyr Gly Lys Leu Trp Thr Asn Gly Val Gly 
    690                 695                 700                 


Gly His His Ser His Val Leu Pro His Pro Lys Pro Pro Val Glu Ser 
705                 710                 715                 720 


Ser Gly Gly Lys Leu Leu Pro Cys Thr Gly Asp Tyr Met Asn Met Ser 
                725                 730                 735     


Pro Val Gly Asp Ser Asn Thr Ser Ser Pro Ser Asp Cys Tyr Tyr Gly 
            740                 745                 750         


Pro Glu Asp Pro Gln His Lys Pro Val Leu Ser Tyr Tyr Ser Leu Pro 
        755                 760                 765             


Arg Ser Phe Lys His Thr Gln Arg Pro Gly Glu Pro Glu Glu Gly Ala 
    770                 775                 780                 


Arg His Gln His Leu Arg Leu Ser Thr Ser Ser Gly Arg Leu Leu Tyr 
785                 790                 795                 800 


Ala Ala Thr Ala Asp Asp Ser Ser Ser Ser Thr Ser Ser Asp Ser Leu 
                805                 810                 815     


Gly Gly Gly Tyr Cys Gly Ala Arg Leu Glu Pro Ser Leu Pro His Pro 
            820                 825                 830         


His His Gln Val Leu Gln Pro His Leu Pro Arg Lys Val Asp Thr Ala 
        835                 840                 845             


Ala Gln Thr Asn Ser Arg Leu Ala Arg Pro Thr Arg Leu Ser Leu Gly 
    850                 855                 860                 


Asp Pro Lys Ala Ser Thr Leu Pro Arg Ala Arg Glu Gln Gln Gln Gln 
865                 870                 875                 880 


Gln Gln Pro Leu Leu His Pro Pro Glu Pro Lys Ser Pro Gly Glu Tyr 
                885                 890                 895     


Val Asn Ile Glu Phe Gly Ser Asp Gln Ser Gly Tyr Leu Ser Gly Pro 
            900                 905                 910         


Val Ala Phe His Ser Ser Pro Ser Val Arg Cys Pro Ser Gln Leu Gln 
        915                 920                 925             


Pro Ala Pro Arg Glu Glu Glu Thr Gly Thr Glu Glu Tyr Met Lys Met 
    930                 935                 940                 


Asp Leu Gly Pro Gly Arg Arg Ala Ala Trp Gln Glu Ser Thr Gly Val 
945                 950                 955                 960 


Glu Met Gly Arg Leu Gly Pro Ala Pro Pro Gly Ala Ala Ser Ile Cys 
                965                 970                 975     


Arg Pro Thr Arg Ala Val Pro Ser Ser Arg Gly Asp Tyr Met Thr Met 
            980                 985                 990         


Gln Met Ser Cys Pro Arg Gln Ser  Tyr Val Asp Thr Ser  Pro Ala Ala 
        995                 1000                 1005             


Pro Val  Ser Tyr Ala Asp Met  Arg Thr Gly Ile Ala  Ala Glu Glu 
    1010                 1015                 1020             


Val Ser  Leu Pro Arg Ala Thr  Met Ala Ala Ala Ser  Ser Ser Ser 
    1025                 1030                 1035             


Ala Ala  Ser Ala Ser Pro Thr  Gly Pro Gln Gly Ala  Ala Glu Leu 
    1040                 1045                 1050             


Ala Ala  His Ser Ser Leu Leu  Gly Gly Pro Gln Gly  Pro Gly Gly 
    1055                 1060                 1065             


Met Ser  Ala Phe Thr Arg Val  Asn Leu Ser Pro Asn  Arg Asn Gln 
    1070                 1075                 1080             


Ser Ala  Lys Val Ile Arg Ala  Asp Pro Gln Gly Cys  Arg Arg Arg 
    1085                 1090                 1095             


His Ser  Ser Glu Thr Phe Ser  Ser Thr Pro Ser Ala  Thr Arg Val 
    1100                 1105                 1110             


Gly Asn  Thr Val Pro Phe Gly  Ala Gly Ala Ala Val  Gly Gly Gly 
    1115                 1120                 1125             


Gly Gly  Ser Ser Ser Ser Ser  Glu Asp Val Lys Arg  His Ser Ser 
    1130                 1135                 1140             


Ala Ser  Phe Glu Asn Val Trp  Leu Arg Pro Gly Glu  Leu Gly Gly 
    1145                 1150                 1155             


Ala Pro  Lys Glu Pro Ala Lys  Leu Cys Gly Ala Ala  Gly Gly Leu 
    1160                 1165                 1170             


Glu Asn  Gly Leu Asn Tyr Ile  Asp Leu Asp Leu Val  Lys Asp Phe 
    1175                 1180                 1185             


Lys Gln  Cys Pro Gln Glu Cys  Thr Pro Glu Pro Gln  Pro Pro Pro 
    1190                 1195                 1200             


Pro Pro  Pro Pro His Gln Pro  Leu Gly Ser Gly Glu  Ser Ser Ser 
    1205                 1210                 1215             


Thr Arg  Arg Ser Ser Glu Asp  Leu Ser Ala Tyr Ala  Ser Ile Ser 
    1220                 1225                 1230             


Phe Gln  Lys Gln Pro Glu Asp  Arg Gln 
    1235                 1240         


<210>  51
<211>  1179
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ala Pro Arg Pro Arg Ala Arg Pro Gly Val Ala Val Ala Cys Cys 
1               5                   10                  15      


Trp Leu Leu Thr Val Val Leu Arg Cys Cys Val Ser Phe Asn Val Asp 
            20                  25                  30          


Val Lys Asn Ser Met Thr Phe Ser Gly Pro Val Glu Asp Met Phe Gly 
        35                  40                  45              


Tyr Thr Val Gln Gln Tyr Glu Asn Glu Glu Gly Lys Trp Val Leu Ile 
    50                  55                  60                  


Gly Ser Pro Leu Val Gly Gln Pro Lys Asn Arg Thr Gly Asp Val Tyr 
65                  70                  75                  80  


Lys Cys Pro Val Gly Arg Gly Glu Ser Leu Pro Cys Val Lys Leu Asp 
                85                  90                  95      


Leu Pro Val Asn Thr Ser Ile Pro Asn Val Thr Glu Val Lys Glu Asn 
            100                 105                 110         


Met Thr Phe Gly Ser Thr Leu Val Thr Asn Pro Asn Gly Gly Phe Leu 
        115                 120                 125             


Ala Cys Gly Pro Leu Tyr Ala Tyr Arg Cys Gly His Leu His Tyr Thr 
    130                 135                 140                 


Thr Gly Ile Cys Ser Asp Val Ser Pro Thr Phe Gln Val Val Asn Ser 
145                 150                 155                 160 


Ile Ala Pro Val Gln Glu Cys Ser Thr Gln Leu Asp Ile Val Ile Val 
                165                 170                 175     


Leu Asp Gly Ser Asn Ser Ile Tyr Pro Trp Asp Ser Val Thr Ala Phe 
            180                 185                 190         


Leu Asn Asp Leu Leu Glu Arg Met Asp Ile Gly Pro Lys Gln Thr Gln 
        195                 200                 205             


Val Gly Ile Val Gln Tyr Gly Glu Asn Val Thr His Glu Phe Asn Leu 
    210                 215                 220                 


Asn Lys Tyr Ser Ser Thr Glu Glu Val Leu Val Ala Ala Lys Lys Ile 
225                 230                 235                 240 


Val Gln Arg Gly Gly Arg Gln Thr Met Thr Ala Leu Gly Ile Asp Thr 
                245                 250                 255     


Ala Arg Lys Glu Ala Phe Thr Glu Ala Arg Gly Ala Arg Arg Gly Val 
            260                 265                 270         


Lys Lys Val Met Val Ile Val Thr Asp Gly Glu Ser His Asp Asn His 
        275                 280                 285             


Arg Leu Lys Lys Val Ile Gln Asp Cys Glu Asp Glu Asn Ile Gln Arg 
    290                 295                 300                 


Phe Ser Ile Ala Ile Leu Gly Ser Tyr Asn Arg Gly Asn Leu Ser Thr 
305                 310                 315                 320 


Glu Lys Phe Val Glu Glu Ile Lys Ser Ile Ala Ser Glu Pro Thr Glu 
                325                 330                 335     


Lys His Phe Phe Asn Val Ser Asp Glu Leu Ala Leu Val Thr Ile Val 
            340                 345                 350         


Lys Thr Leu Gly Glu Arg Ile Phe Ala Leu Glu Ala Thr Ala Asp Gln 
        355                 360                 365             


Ser Ala Ala Ser Phe Glu Met Glu Met Ser Gln Thr Gly Phe Ser Ala 
    370                 375                 380                 


His Tyr Ser Gln Asp Trp Val Met Leu Gly Ala Val Gly Ala Tyr Asp 
385                 390                 395                 400 


Trp Asn Gly Thr Val Val Met Gln Lys Ala Ser Gln Ile Ile Ile Pro 
                405                 410                 415     


Arg Asn Thr Thr Phe Asn Val Glu Ser Thr Lys Lys Asn Glu Pro Leu 
            420                 425                 430         


Ala Ser Tyr Leu Gly Tyr Thr Val Asn Ser Ala Thr Ala Ser Ser Gly 
        435                 440                 445             


Asp Val Leu Tyr Ile Ala Gly Gln Pro Arg Tyr Asn His Thr Gly Gln 
    450                 455                 460                 


Val Ile Ile Tyr Arg Met Glu Asp Gly Asn Ile Lys Ile Leu Gln Thr 
465                 470                 475                 480 


Leu Ser Gly Glu Gln Ile Gly Ser Tyr Phe Gly Ser Ile Leu Thr Thr 
                485                 490                 495     


Thr Asp Ile Asp Lys Asp Ser Asn Thr Asp Ile Leu Leu Val Gly Ala 
            500                 505                 510         


Pro Met Tyr Met Gly Thr Glu Lys Glu Glu Gln Gly Lys Val Tyr Val 
        515                 520                 525             


Tyr Ala Leu Asn Gln Thr Arg Phe Glu Tyr Gln Met Ser Leu Glu Pro 
    530                 535                 540                 


Ile Lys Gln Thr Cys Cys Ser Ser Arg Gln His Asn Ser Cys Thr Thr 
545                 550                 555                 560 


Glu Asn Lys Asn Glu Pro Cys Gly Ala Arg Phe Gly Thr Ala Ile Ala 
                565                 570                 575     


Ala Val Lys Asp Leu Asn Leu Asp Gly Phe Asn Asp Ile Val Ile Gly 
            580                 585                 590         


Ala Pro Leu Glu Asp Asp His Gly Gly Ala Val Tyr Ile Tyr His Gly 
        595                 600                 605             


Ser Gly Lys Thr Ile Arg Lys Glu Tyr Ala Gln Arg Ile Pro Ser Gly 
    610                 615                 620                 


Gly Asp Gly Lys Thr Leu Lys Phe Phe Gly Gln Ser Ile His Gly Glu 
625                 630                 635                 640 


Met Asp Leu Asn Gly Asp Gly Leu Thr Asp Val Thr Ile Gly Gly Leu 
                645                 650                 655     


Gly Gly Ala Ala Leu Phe Trp Ser Arg Asp Val Ala Val Val Lys Val 
            660                 665                 670         


Thr Met Asn Phe Glu Pro Asn Lys Val Asn Ile Gln Lys Lys Asn Cys 
        675                 680                 685             


His Met Glu Gly Lys Glu Thr Val Cys Ile Asn Ala Thr Val Cys Phe 
    690                 695                 700                 


Asp Val Lys Leu Lys Ser Lys Glu Asp Thr Ile Tyr Glu Ala Asp Leu 
705                 710                 715                 720 


Gln Tyr Arg Val Thr Leu Asp Ser Leu Arg Gln Ile Ser Arg Ser Phe 
                725                 730                 735     


Phe Ser Gly Thr Gln Glu Arg Lys Val Gln Arg Asn Ile Thr Val Arg 
            740                 745                 750         


Lys Ser Glu Cys Thr Lys His Ser Phe Tyr Met Leu Asp Lys His Asp 
        755                 760                 765             


Phe Gln Asp Ser Val Arg Ile Thr Leu Asp Phe Asn Leu Thr Asp Pro 
    770                 775                 780                 


Glu Asn Gly Pro Val Leu Asp Asp Ser Leu Pro Asn Ser Val His Glu 
785                 790                 795                 800 


Tyr Ile Pro Phe Ala Lys Asp Cys Gly Asn Lys Glu Lys Cys Ile Ser 
                805                 810                 815     


Asp Leu Ser Leu His Val Ala Thr Thr Glu Lys Asp Leu Leu Ile Val 
            820                 825                 830         


Arg Ser Gln Asn Asp Lys Phe Asn Val Ser Leu Thr Val Lys Asn Thr 
        835                 840                 845             


Lys Asp Ser Ala Tyr Asn Thr Arg Thr Ile Val His Tyr Ser Pro Asn 
    850                 855                 860                 


Leu Val Phe Ser Gly Ile Glu Ala Ile Gln Lys Asp Ser Cys Glu Ser 
865                 870                 875                 880 


Asn His Asn Ile Thr Cys Lys Val Gly Tyr Pro Phe Leu Arg Arg Gly 
                885                 890                 895     


Glu Met Val Thr Phe Lys Ile Leu Phe Gln Phe Asn Thr Ser Tyr Leu 
            900                 905                 910         


Met Glu Asn Val Thr Ile Tyr Leu Ser Ala Thr Ser Asp Ser Glu Glu 
        915                 920                 925             


Pro Pro Glu Thr Leu Ser Asp Asn Val Val Asn Ile Ser Ile Pro Val 
    930                 935                 940                 


Lys Tyr Glu Val Gly Leu Gln Phe Tyr Ser Ser Ala Ser Glu Tyr His 
945                 950                 955                 960 


Ile Ser Ile Ala Ala Asn Glu Thr Val Pro Glu Val Ile Asn Ser Thr 
                965                 970                 975     


Glu Asp Ile Gly Asn Glu Ile Asn Ile Phe Tyr Leu Ile Arg Lys Ser 
            980                 985                 990         


Gly Ser Phe Pro Met Pro Glu Leu  Lys Leu Ser Ile Ser  Phe Pro Asn 
        995                 1000                 1005             


Met Thr  Ser Asn Gly Tyr Pro  Val Leu Tyr Pro Thr  Gly Leu Ser 
    1010                 1015                 1020             


Ser Ser  Glu Asn Ala Asn Cys  Arg Pro His Ile Phe  Glu Asp Pro 
    1025                 1030                 1035             


Phe Ser  Ile Asn Ser Gly Lys  Lys Met Thr Thr Ser  Thr Asp His 
    1040                 1045                 1050             


Leu Lys  Arg Gly Thr Ile Leu  Asp Cys Asn Thr Cys  Lys Phe Ala 
    1055                 1060                 1065             


Thr Ile  Thr Cys Asn Leu Thr  Ser Ser Asp Ile Ser  Gln Val Asn 
    1070                 1075                 1080             


Val Ser  Leu Ile Leu Trp Lys  Pro Thr Phe Ile Lys  Ser Tyr Phe 
    1085                 1090                 1095             


Ser Ser  Leu Asn Leu Thr Ile  Arg Gly Glu Leu Arg  Ser Glu Asn 
    1100                 1105                 1110             


Ala Ser  Leu Val Leu Ser Ser  Ser Asn Gln Lys Arg  Glu Leu Ala 
    1115                 1120                 1125             


Ile Gln  Ile Ser Lys Asp Gly  Leu Pro Gly Arg Val  Pro Leu Trp 
    1130                 1135                 1140             


Val Ile  Leu Leu Ser Ala Phe  Ala Gly Leu Leu Leu  Leu Met Leu 
    1145                 1150                 1155             


Leu Ile  Leu Ala Leu Trp Lys  Ile Gly Phe Phe Lys  Arg Pro Leu 
    1160                 1165                 1170             


Lys Lys  Lys Met Glu Lys 
    1175                 


<210>  52
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Glu Ala Val Leu Ile Asp Leu Phe Gly Leu Lys Leu Asn Ser 
1               5                   10                  15      


Gln Lys Asn Cys His Gln Thr Leu Leu Lys Thr Leu Asn Ala Val Gln 
            20                  25                  30          


Tyr His His Ala Ala Lys Ala Lys Phe Leu Cys Ile Met Cys Cys Ser 
        35                  40                  45              


Asn Ile Ser Tyr Glu Arg Asp Gly Glu Gln Asp Asn Cys Glu Ile Glu 
    50                  55                  60                  


Thr Ser Asn Gly Leu Ser Ala Leu Leu Glu Glu Phe Glu Ile Val Ser 
65                  70                  75                  80  


Cys Pro Ser Met Ala Ala Thr Leu Tyr Thr Ile Lys Gln Lys Ile Asp 
                85                  90                  95      


Glu Lys Asn Leu Ser Ser Ile Lys Val Ile Val Pro Arg His Arg Lys 
            100                 105                 110         


Thr Leu Met Lys Ala Phe Ile Asp Gln Leu Phe Thr Asp Val Tyr Asn 
        115                 120                 125             


Phe Glu Phe Glu Asp Leu Gln Val Thr Phe Arg Gly Gly Leu Phe Lys 
    130                 135                 140                 


Gln Ser Ile Glu Ile Asn Val Ile Thr Ala Gln Glu Leu Arg Gly Ile 
145                 150                 155                 160 


Gln Asn Glu Ile Glu Thr Phe Leu Arg Ser Leu Pro Ala Leu Arg Gly 
                165                 170                 175     


Lys Leu Thr Ile Ile Thr Ser Ser Leu Ile Pro Asp Ile Phe Ile His 
            180                 185                 190         


Gly Phe Thr Thr Arg Thr Gly Gly Ile Ser Tyr Ile Pro Thr Leu Ser 
        195                 200                 205             


Ser Phe Asn Leu Phe Ser Ser Ser Lys Arg Arg Asp Pro Lys Val Val 
    210                 215                 220                 


Val Gln Glu Asn Leu Arg Arg Leu Ala Asn Ala Ala Gly Phe Asn Val 
225                 230                 235                 240 


Glu Lys Phe Tyr Arg Ile Lys Thr His His Ser Asn Asp Ile Trp Ile 
                245                 250                 255     


Met Gly Arg Lys Glu Pro Asp Ser Tyr Asp Gly Ile Thr Thr Asn Gln 
            260                 265                 270         


Arg Gly Val Thr Ile Ala Ala Leu Gly Ala Asp Cys Ile Pro Ile Val 
        275                 280                 285             


Phe Ala Asp Pro Val Lys Lys Ala Cys Gly Val Ala His Ala Gly Trp 
    290                 295                 300                 


Lys Gly Thr Leu Leu Gly Val Ala Met Ala Thr Val Asn Ala Met Ile 
305                 310                 315                 320 


Ala Glu Tyr Gly Cys Ser Leu Glu Asp Ile Val Val Val Leu Gly Pro 
                325                 330                 335     


Ser Val Gly Pro Cys Cys Phe Thr Leu Pro Arg Glu Ser Ala Glu Ala 
            340                 345                 350         


Phe His Asn Leu His Pro Ala Cys Val Gln Leu Phe Asp Ser Pro Asn 
        355                 360                 365             


Pro Cys Ile Asp Ile Arg Lys Ala Thr Arg Ile Leu Leu Glu Gln Gly 
    370                 375                 380                 


Gly Ile Leu Pro Gln Asn Ile Gln Asp Gln Asn Gln Asp Leu Asn Leu 
385                 390                 395                 400 


Cys Thr Ser Cys His Pro Asp Lys Phe Phe Ser His Val Arg Asp Gly 
                405                 410                 415     


Leu Asn Phe Gly Thr Gln Ile Gly Phe Ile Ser Ile Lys Glu 
            420                 425                 430 


<210>  53
<211>  1823
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Ala Leu Ser Ser Ala Trp Arg Ser Val Leu Pro Leu Trp Leu Leu 
1               5                   10                  15      


Trp Ser Ala Ala Cys Ser Arg Ala Ala Ser Gly Asp Asp Asn Ala Phe 
            20                  25                  30          


Pro Phe Asp Ile Glu Gly Ser Ser Ala Val Gly Arg Gln Asp Pro Pro 
        35                  40                  45              


Glu Thr Ser Glu Pro Arg Val Ala Leu Gly Arg Leu Pro Pro Ala Ala 
    50                  55                  60                  


Glu Lys Cys Asn Ala Gly Phe Phe His Thr Leu Ser Gly Glu Cys Val 
65                  70                  75                  80  


Pro Cys Asp Cys Asn Gly Asn Ser Asn Glu Cys Leu Asp Gly Ser Gly 
                85                  90                  95      


Tyr Cys Val His Cys Gln Arg Asn Thr Thr Gly Glu His Cys Glu Lys 
            100                 105                 110         


Cys Leu Asp Gly Tyr Ile Gly Asp Ser Ile Arg Gly Ala Pro Gln Phe 
        115                 120                 125             


Cys Gln Pro Cys Pro Cys Pro Leu Pro His Leu Ala Asn Phe Ala Glu 
    130                 135                 140                 


Ser Cys Tyr Arg Lys Asn Gly Ala Val Arg Cys Ile Cys Asn Glu Asn 
145                 150                 155                 160 


Tyr Ala Gly Pro Asn Cys Glu Arg Cys Ala Pro Gly Tyr Tyr Gly Asn 
                165                 170                 175     


Pro Leu Leu Ile Gly Ser Thr Cys Lys Lys Cys Asp Cys Ser Gly Asn 
            180                 185                 190         


Ser Asp Pro Asn Leu Ile Phe Glu Asp Cys Asp Glu Val Thr Gly Gln 
        195                 200                 205             


Cys Arg Asn Cys Leu Arg Asn Thr Thr Gly Phe Lys Cys Glu Arg Cys 
    210                 215                 220                 


Ala Pro Gly Tyr Tyr Gly Asp Ala Arg Ile Ala Lys Asn Cys Ala Val 
225                 230                 235                 240 


Cys Asn Cys Gly Gly Gly Pro Cys Asp Ser Val Thr Gly Glu Cys Leu 
                245                 250                 255     


Glu Glu Gly Phe Glu Pro Pro Thr Gly Met Asp Cys Pro Thr Ile Ser 
            260                 265                 270         


Cys Asp Lys Cys Val Trp Asp Leu Thr Asp Ala Leu Arg Leu Ala Ala 
        275                 280                 285             


Leu Ser Ile Glu Glu Gly Lys Ser Gly Val Leu Ser Val Ser Ser Gly 
    290                 295                 300                 


Ala Ala Ala His Arg His Val Asn Glu Ile Asn Ala Thr Ile Tyr Leu 
305                 310                 315                 320 


Leu Lys Thr Lys Leu Ser Glu Arg Glu Asn Gln Tyr Ala Leu Arg Lys 
                325                 330                 335     


Ile Gln Ile Asn Asn Ala Glu Asn Thr Met Lys Ser Leu Leu Ser Asp 
            340                 345                 350         


Val Glu Glu Leu Val Glu Lys Glu Asn Gln Ala Ser Arg Lys Gly Gln 
        355                 360                 365             


Leu Val Gln Lys Glu Ser Met Asp Thr Ile Asn His Ala Ser Gln Leu 
    370                 375                 380                 


Val Glu Gln Ala His Asp Met Arg Asp Lys Ile Gln Glu Ile Asn Asn 
385                 390                 395                 400 


Lys Met Leu Tyr Tyr Gly Glu Glu His Glu Leu Ser Pro Lys Glu Ile 
                405                 410                 415     


Ser Glu Lys Leu Val Leu Ala Gln Lys Met Leu Glu Glu Ile Arg Ser 
            420                 425                 430         


Arg Gln Pro Phe Phe Thr Gln Arg Glu Leu Val Asp Glu Glu Ala Asp 
        435                 440                 445             


Glu Ala Tyr Glu Leu Leu Ser Gln Ala Glu Ser Trp Gln Arg Leu His 
    450                 455                 460                 


Asn Glu Thr Arg Thr Leu Phe Pro Val Val Leu Glu Gln Leu Asp Asp 
465                 470                 475                 480 


Tyr Asn Ala Lys Leu Ser Asp Leu Gln Glu Ala Leu Asp Gln Ala Leu 
                485                 490                 495     


Asn Tyr Val Arg Asp Ala Glu Asp Met Asn Arg Ala Thr Ala Ala Arg 
            500                 505                 510         


Gln Arg Asp His Glu Lys Gln Gln Glu Arg Val Arg Glu Gln Met Glu 
        515                 520                 525             


Val Val Asn Met Ser Leu Ser Thr Ser Ala Asp Ser Leu Thr Thr Pro 
    530                 535                 540                 


Arg Leu Thr Leu Ser Glu Leu Asp Asp Ile Ile Lys Asn Ala Ser Gly 
545                 550                 555                 560 


Ile Tyr Ala Glu Ile Asp Gly Ala Lys Ser Glu Leu Gln Val Lys Leu 
                565                 570                 575     


Ser Asn Leu Ser Asn Leu Ser His Asp Leu Val Gln Glu Ala Ile Asp 
            580                 585                 590         


His Ala Gln Asp Leu Gln Gln Glu Ala Asn Glu Leu Ser Arg Lys Leu 
        595                 600                 605             


His Ser Ser Asp Met Asn Gly Leu Val Gln Lys Ala Leu Asp Ala Ser 
    610                 615                 620                 


Asn Val Tyr Glu Asn Ile Val Asn Tyr Val Ser Glu Ala Asn Glu Thr 
625                 630                 635                 640 


Ala Glu Phe Ala Leu Asn Thr Thr Asp Arg Ile Tyr Asp Ala Val Ser 
                645                 650                 655     


Gly Ile Asp Thr Gln Ile Ile Tyr His Lys Asp Glu Ser Glu Asn Leu 
            660                 665                 670         


Leu Asn Gln Ala Arg Glu Leu Gln Ala Lys Ala Glu Ser Ser Ser Asp 
        675                 680                 685             


Glu Ala Val Ala Asp Thr Ser Arg Arg Val Gly Gly Ala Leu Ala Arg 
    690                 695                 700                 


Lys Ser Ala Leu Lys Thr Arg Leu Ser Asp Ala Val Lys Gln Leu Gln 
705                 710                 715                 720 


Ala Ala Glu Arg Gly Asp Ala Gln Gln Arg Leu Gly Gln Ser Arg Leu 
                725                 730                 735     


Ile Thr Glu Glu Ala Asn Arg Thr Thr Met Glu Val Gln Gln Ala Thr 
            740                 745                 750         


Ala Pro Met Ala Asn Asn Leu Thr Asn Trp Ser Gln Asn Leu Gln His 
        755                 760                 765             


Phe Asp Ser Ser Ala Tyr Asn Thr Ala Val Asn Ser Ala Arg Asp Ala 
    770                 775                 780                 


Val Arg Asn Leu Thr Glu Val Val Pro Gln Leu Leu Asp Gln Leu Arg 
785                 790                 795                 800 


Thr Val Glu Gln Lys Arg Pro Ala Ser Asn Val Ser Ala Ser Ile Gln 
                805                 810                 815     


Arg Ile Arg Glu Leu Ile Ala Gln Thr Arg Ser Val Ala Ser Lys Ile 
            820                 825                 830         


Gln Val Ser Met Met Phe Asp Gly Gln Ser Ala Val Glu Val His Ser 
        835                 840                 845             


Arg Thr Ser Met Asp Asp Leu Lys Ala Phe Thr Ser Leu Ser Leu Tyr 
    850                 855                 860                 


Met Lys Pro Pro Val Lys Arg Pro Glu Leu Thr Glu Thr Ala Asp Gln 
865                 870                 875                 880 


Phe Ile Leu Tyr Leu Gly Ser Lys Asn Ala Lys Lys Glu Tyr Met Gly 
                885                 890                 895     


Leu Ala Ile Lys Asn Asp Asn Leu Val Tyr Val Tyr Asn Leu Gly Thr 
            900                 905                 910         


Lys Asp Val Glu Ile Pro Leu Asp Ser Lys Pro Val Ser Ser Trp Pro 
        915                 920                 925             


Ala Tyr Phe Ser Ile Val Lys Ile Glu Arg Val Gly Lys His Gly Lys 
    930                 935                 940                 


Val Phe Leu Thr Val Pro Ser Leu Ser Ser Thr Ala Glu Glu Lys Phe 
945                 950                 955                 960 


Ile Lys Lys Gly Glu Phe Ser Gly Asp Asp Ser Leu Leu Asp Leu Asp 
                965                 970                 975     


Pro Glu Asp Thr Val Phe Tyr Val Gly Gly Val Pro Ser Asn Phe Lys 
            980                 985                 990         


Leu Pro Thr Ser Leu Asn Leu Pro  Gly Phe Val Gly Cys  Leu Glu Leu 
        995                 1000                 1005             


Ala Thr  Leu Asn Asn Asp Val  Ile Ser Leu Tyr Asn  Phe Lys His 
    1010                 1015                 1020             


Ile Tyr  Asn Met Asp Pro Ser  Thr Ser Val Pro Cys  Ala Arg Asp 
    1025                 1030                 1035             


Lys Leu  Ala Phe Thr Gln Ser  Arg Ala Ala Ser Tyr  Phe Phe Asp 
    1040                 1045                 1050             


Gly Ser  Gly Tyr Ala Val Val  Arg Asp Ile Thr Arg  Arg Gly Lys 
    1055                 1060                 1065             


Phe Gly  Gln Val Thr Arg Phe  Asp Ile Glu Val Arg  Thr Pro Ala 
    1070                 1075                 1080             


Asp Asn  Gly Leu Ile Leu Leu  Met Val Asn Gly Ser  Met Phe Phe 
    1085                 1090                 1095             


Arg Leu  Glu Met Arg Asn Gly  Tyr Leu His Val Phe  Tyr Asp Phe 
    1100                 1105                 1110             


Gly Phe  Ser Gly Gly Pro Val  His Leu Glu Asp Thr  Leu Lys Lys 
    1115                 1120                 1125             


Ala Gln  Ile Asn Asp Ala Lys  Tyr His Glu Ile Ser  Ile Ile Tyr 
    1130                 1135                 1140             


His Asn  Asp Lys Lys Met Ile  Leu Val Val Asp Arg  Arg His Val 
    1145                 1150                 1155             


Lys Ser  Met Asp Asn Glu Lys  Met Lys Ile Pro Phe  Thr Asp Ile 
    1160                 1165                 1170             


Tyr Ile  Gly Gly Ala Pro Pro  Glu Ile Leu Gln Ser  Arg Ala Leu 
    1175                 1180                 1185             


Arg Ala  His Leu Pro Leu Asp  Ile Asn Phe Arg Gly  Cys Met Lys 
    1190                 1195                 1200             


Gly Phe  Gln Phe Gln Lys Lys  Asp Phe Asn Leu Leu  Glu Gln Thr 
    1205                 1210                 1215             


Glu Thr  Leu Gly Val Gly Tyr  Gly Cys Pro Glu Asp  Ser Leu Ile 
    1220                 1225                 1230             


Ser Arg  Arg Ala Tyr Phe Asn  Gly Gln Ser Phe Ile  Ala Ser Ile 
    1235                 1240                 1245             


Gln Lys  Ile Ser Phe Phe Asp  Gly Phe Glu Gly Gly  Phe Asn Phe 
    1250                 1255                 1260             


Arg Thr  Leu Gln Pro Asn Gly  Leu Leu Phe Tyr Tyr  Ala Ser Gly 
    1265                 1270                 1275             


Ser Asp  Val Phe Ser Ile Ser  Leu Asp Asn Gly Thr  Val Ile Met 
    1280                 1285                 1290             


Asp Val  Lys Gly Ile Lys Val  Gln Ser Val Asp Lys  Gln Tyr Asn 
    1295                 1300                 1305             


Asp Gly  Leu Ser His Phe Val  Ile Ser Ser Val Ser  Pro Thr Arg 
    1310                 1315                 1320             


Tyr Glu  Leu Ile Val Asp Lys  Ser Arg Val Gly Ser  Lys Asn Pro 
    1325                 1330                 1335             


Thr Lys  Gly Lys Ile Glu Gln  Thr Gln Ala Ser Glu  Lys Lys Phe 
    1340                 1345                 1350             


Tyr Phe  Gly Gly Ser Pro Ile  Ser Ala Gln Tyr Ala  Asn Phe Thr 
    1355                 1360                 1365             


Gly Cys  Ile Ser Asn Ala Tyr  Phe Thr Arg Val Asp  Arg Asp Val 
    1370                 1375                 1380             


Glu Val  Glu Asp Phe Gln Arg  Tyr Thr Glu Lys Val  His Thr Ser 
    1385                 1390                 1395             


Leu Tyr  Glu Cys Pro Ile Glu  Ser Ser Pro Leu Phe  Leu Leu His 
    1400                 1405                 1410             


Lys Lys  Gly Lys Asn Leu Ser  Lys Pro Lys Ala Ser  Gln Asn Lys 
    1415                 1420                 1425             


Lys Gly  Gly Lys Ser Lys Asp  Ala Pro Ser Trp Asp  Pro Val Ala 
    1430                 1435                 1440             


Leu Lys  Leu Pro Glu Arg Asn  Thr Pro Arg Asn Ser  His Cys His 
    1445                 1450                 1455             


Leu Ser  Asn Ser Pro Arg Ala  Ile Glu His Ala Tyr  Gln Tyr Gly 
    1460                 1465                 1470             


Gly Thr  Ala Asn Ser Arg Gln  Glu Phe Glu His Leu  Lys Gly Asp 
    1475                 1480                 1485             


Phe Gly  Ala Lys Ser Gln Phe  Ser Ile Arg Leu Arg  Thr Arg Ser 
    1490                 1495                 1500             


Ser His  Gly Met Ile Phe Tyr  Val Ser Asp Gln Glu  Glu Asn Asp 
    1505                 1510                 1515             


Phe Met  Thr Leu Phe Leu Ala  His Gly Arg Leu Val  Tyr Met Phe 
    1520                 1525                 1530             


Asn Val  Gly His Lys Lys Leu  Lys Ile Arg Ser Gln  Glu Lys Tyr 
    1535                 1540                 1545             


Asn Asp  Gly Leu Trp His Asp  Val Ile Phe Ile Arg  Glu Arg Ser 
    1550                 1555                 1560             


Ser Gly  Arg Leu Val Ile Asp  Gly Leu Arg Val Leu  Glu Glu Ser 
    1565                 1570                 1575             


Leu Pro  Pro Thr Glu Ala Thr  Trp Lys Ile Lys Gly  Pro Ile Tyr 
    1580                 1585                 1590             


Leu Gly  Gly Val Ala Pro Gly  Lys Ala Val Lys Asn  Val Gln Ile 
    1595                 1600                 1605             


Asn Ser  Ile Tyr Ser Phe Ser  Gly Cys Leu Ser Asn  Leu Gln Leu 
    1610                 1615                 1620             


Asn Gly  Ala Ser Ile Thr Ser  Ala Ser Gln Thr Phe  Ser Val Thr 
    1625                 1630                 1635             


Pro Cys  Phe Glu Gly Pro Met  Glu Thr Gly Thr Tyr  Phe Ser Thr 
    1640                 1645                 1650             


Glu Gly  Gly Tyr Val Val Leu  Asp Glu Ser Phe Asn  Ile Gly Leu 
    1655                 1660                 1665             


Lys Phe  Glu Ile Ala Phe Glu  Val Arg Pro Arg Ser  Ser Ser Gly 
    1670                 1675                 1680             


Thr Leu  Val His Gly His Ser  Val Asn Gly Glu Tyr  Leu Asn Val 
    1685                 1690                 1695             


His Met  Lys Asn Gly Gln Val  Ile Val Lys Val Asn  Asn Gly Ile 
    1700                 1705                 1710             


Arg Asp  Phe Ser Thr Ser Val  Thr Pro Lys Gln Ser  Leu Cys Asp 
    1715                 1720                 1725             


Gly Arg  Trp His Arg Ile Thr  Val Ile Arg Asp Ser  Asn Val Val 
    1730                 1735                 1740             


Gln Leu  Asp Val Asp Ser Glu  Val Asn His Val Val  Gly Pro Leu 
    1745                 1750                 1755             


Asn Pro  Lys Pro Ile Asp His  Arg Glu Pro Val Phe  Val Gly Gly 
    1760                 1765                 1770             


Val Pro  Glu Ser Leu Leu Thr  Pro Arg Leu Ala Pro  Ser Lys Pro 
    1775                 1780                 1785             


Phe Thr  Gly Cys Ile Arg His  Phe Val Ile Asp Gly  His Pro Val 
    1790                 1795                 1800             


Ser Phe  Ser Lys Ala Ala Leu  Val Ser Gly Ala Val  Ser Ile Asn 
    1805                 1810                 1815             


Ser Cys  Pro Ala Ala 
    1820             


<210>  54
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ser Leu Ser Ala Phe Thr Leu Phe Leu Ala Leu Ile Gly Gly Thr 
1               5                   10                  15      


Ser Gly Gln Tyr Tyr Asp Tyr Asp Phe Pro Leu Ser Ile Tyr Gly Gln 
            20                  25                  30          


Ser Ser Pro Asn Cys Ala Pro Glu Cys Asn Cys Pro Glu Ser Tyr Pro 
        35                  40                  45              


Ser Ala Met Tyr Cys Asp Glu Leu Lys Leu Lys Ser Val Pro Met Val 
    50                  55                  60                  


Pro Pro Gly Ile Lys Tyr Leu Tyr Leu Arg Asn Asn Gln Ile Asp His 
65                  70                  75                  80  


Ile Asp Glu Lys Ala Phe Glu Asn Val Thr Asp Leu Gln Trp Leu Ile 
                85                  90                  95      


Leu Asp His Asn Leu Leu Glu Asn Ser Lys Ile Lys Gly Arg Val Phe 
            100                 105                 110         


Ser Lys Leu Lys Gln Leu Lys Lys Leu His Ile Asn His Asn Asn Leu 
        115                 120                 125             


Thr Glu Ser Val Gly Pro Leu Pro Lys Ser Leu Glu Asp Leu Gln Leu 
    130                 135                 140                 


Thr His Asn Lys Ile Thr Lys Leu Gly Ser Phe Glu Gly Leu Val Asn 
145                 150                 155                 160 


Leu Thr Phe Ile His Leu Gln His Asn Arg Leu Lys Glu Asp Ala Val 
                165                 170                 175     


Ser Ala Ala Phe Lys Gly Leu Lys Ser Leu Glu Tyr Leu Asp Leu Ser 
            180                 185                 190         


Phe Asn Gln Ile Ala Arg Leu Pro Ser Gly Leu Pro Val Ser Leu Leu 
        195                 200                 205             


Thr Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn Ile Pro Asp Glu Tyr 
    210                 215                 220                 


Phe Lys Arg Phe Asn Ala Leu Gln Tyr Leu Arg Leu Ser His Asn Glu 
225                 230                 235                 240 


Leu Ala Asp Ser Gly Ile Pro Gly Asn Ser Phe Asn Val Ser Ser Leu 
                245                 250                 255     


Val Glu Leu Asp Leu Ser Tyr Asn Lys Leu Lys Asn Ile Pro Thr Val 
            260                 265                 270         


Asn Glu Asn Leu Glu Asn Tyr Tyr Leu Glu Val Asn Gln Leu Glu Lys 
        275                 280                 285             


Phe Asp Ile Lys Ser Phe Cys Lys Ile Leu Gly Pro Leu Ser Tyr Ser 
    290                 295                 300                 


Lys Ile Lys His Leu Arg Leu Asp Gly Asn Arg Ile Ser Glu Thr Ser 
305                 310                 315                 320 


Leu Pro Pro Asp Met Tyr Glu Cys Leu Arg Val Ala Asn Glu Val Thr 
                325                 330                 335     


Leu Asn 
        


<210>  55
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  55

Met His Pro Gly Val Leu Ala Ala Phe Leu Phe Leu Ser Trp Thr His 
1               5                   10                  15      


Cys Arg Ala Leu Pro Leu Pro Ser Gly Gly Asp Glu Asp Asp Leu Ser 
            20                  25                  30          


Glu Glu Asp Leu Gln Phe Ala Glu Arg Tyr Leu Arg Ser Tyr Tyr His 
        35                  40                  45              


Pro Thr Asn Leu Ala Gly Ile Leu Lys Glu Asn Ala Ala Ser Ser Met 
    50                  55                  60                  


Thr Glu Arg Leu Arg Glu Met Gln Ser Phe Phe Gly Leu Glu Val Thr 
65                  70                  75                  80  


Gly Lys Leu Asp Asp Asn Thr Leu Asp Val Met Lys Lys Pro Arg Cys 
                85                  90                  95      


Gly Val Pro Asp Val Gly Glu Tyr Asn Val Phe Pro Arg Thr Leu Lys 
            100                 105                 110         


Trp Ser Lys Met Asn Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp 
        115                 120                 125             


Met Thr His Ser Glu Val Glu Lys Ala Phe Lys Lys Ala Phe Lys Val 
    130                 135                 140                 


Trp Ser Asp Val Thr Pro Leu Asn Phe Thr Arg Leu His Asp Gly Ile 
145                 150                 155                 160 


Ala Asp Ile Met Ile Ser Phe Gly Ile Lys Glu His Gly Asp Phe Tyr 
                165                 170                 175     


Pro Phe Asp Gly Pro Ser Gly Leu Leu Ala His Ala Phe Pro Pro Gly 
            180                 185                 190         


Pro Asn Tyr Gly Gly Asp Ala His Phe Asp Asp Asp Glu Thr Trp Thr 
        195                 200                 205             


Ser Ser Ser Lys Gly Tyr Asn Leu Phe Leu Val Ala Ala His Glu Phe 
    210                 215                 220                 


Gly His Ser Leu Gly Leu Asp His Ser Lys Asp Pro Gly Ala Leu Met 
225                 230                 235                 240 


Phe Pro Ile Tyr Thr Tyr Thr Gly Lys Ser His Phe Met Leu Pro Asp 
                245                 250                 255     


Asp Asp Val Gln Gly Ile Gln Ser Leu Tyr Gly Pro Gly Asp Glu Asp 
            260                 265                 270         


Pro Asn Pro Lys His Pro Lys Thr Pro Asp Lys Cys Asp Pro Ser Leu 
        275                 280                 285             


Ser Leu Asp Ala Ile Thr Ser Leu Arg Gly Glu Thr Met Ile Phe Lys 
    290                 295                 300                 


Asp Arg Phe Phe Trp Arg Leu His Pro Gln Gln Val Asp Ala Glu Leu 
305                 310                 315                 320 


Phe Leu Thr Lys Ser Phe Trp Pro Glu Leu Pro Asn Arg Ile Asp Ala 
                325                 330                 335     


Ala Tyr Glu His Pro Ser His Asp Leu Ile Phe Ile Phe Arg Gly Arg 
            340                 345                 350         


Lys Phe Trp Ala Leu Asn Gly Tyr Asp Ile Leu Glu Gly Tyr Pro Lys 
        355                 360                 365             


Lys Ile Ser Glu Leu Gly Leu Pro Lys Glu Val Lys Lys Ile Ser Ala 
    370                 375                 380                 


Ala Val His Phe Glu Asp Thr Gly Lys Thr Leu Leu Phe Ser Gly Asn 
385                 390                 395                 400 


Gln Val Trp Arg Tyr Asp Asp Thr Asn His Ile Met Asp Lys Asp Tyr 
                405                 410                 415     


Pro Arg Leu Ile Glu Glu Asp Phe Pro Gly Ile Gly Asp Lys Val Asp 
            420                 425                 430         


Ala Val Tyr Glu Lys Asn Gly Tyr Ile Tyr Phe Phe Asn Gly Pro Ile 
        435                 440                 445             


Gln Phe Glu Tyr Ser Ile Trp Ser Asn Arg Ile Val Arg Val Met Pro 
    450                 455                 460                 


Ala Asn Ser Ile Leu Trp Cys 
465                 470     


<210>  56
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ser Phe Phe Gln Leu Leu Met Lys Arg Lys Glu Leu Ile Pro Leu 
1               5                   10                  15      


Val Val Phe Met Thr Val Ala Ala Gly Gly Ala Ser Ser Phe Ala Val 
            20                  25                  30          


Tyr Ser Leu Trp Lys Thr Asp Val Ile Leu Asp Arg Lys Lys Asn Pro 
        35                  40                  45              


Glu Pro Trp Glu Thr Val Asp Pro Thr Val Pro Gln Lys Leu Ile Thr 
    50                  55                  60                  


Ile Asn Gln Gln Trp Lys Pro Ile Glu Glu Leu Gln Asn Val Gln Arg 
65                  70                  75                  80  


Val Thr Lys 
            


<210>  57
<211>  731
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ala Ser Cys Pro Asp Ser Asp Asn Ser Trp Val Leu Ala Gly Ser 
1               5                   10                  15      


Glu Ser Leu Pro Val Glu Thr Leu Gly Pro Ala Ser Arg Met Asp Pro 
            20                  25                  30          


Glu Ser Glu Arg Ala Leu Gln Ala Pro His Ser Pro Ser Lys Thr Asp 
        35                  40                  45              


Gly Lys Glu Leu Ala Gly Thr Met Asp Gly Glu Gly Thr Leu Phe Gln 
    50                  55                  60                  


Thr Glu Ser Pro Gln Ser Gly Ser Ile Leu Thr Glu Glu Thr Glu Val 
65                  70                  75                  80  


Lys Gly Thr Leu Glu Gly Asp Val Cys Gly Val Glu Pro Pro Gly Pro 
                85                  90                  95      


Gly Asp Thr Val Val Gln Gly Asp Leu Gln Glu Thr Thr Val Val Thr 
            100                 105                 110         


Gly Leu Gly Pro Asp Thr Gln Asp Leu Glu Gly Gln Ser Pro Pro Gln 
        115                 120                 125             


Ser Leu Pro Ser Thr Pro Lys Ala Ala Trp Ile Arg Glu Glu Gly Arg 
    130                 135                 140                 


Cys Ser Ser Ser Asp Asp Asp Thr Asp Val Asp Met Glu Gly Leu Arg 
145                 150                 155                 160 


Arg Arg Arg Gly Arg Glu Ala Gly Pro Pro Gln Pro Met Val Pro Leu 
                165                 170                 175     


Ala Val Glu Asn Gln Ala Gly Gly Glu Gly Ala Gly Gly Glu Leu Gly 
            180                 185                 190         


Ile Ser Leu Asn Met Cys Leu Leu Gly Ala Leu Val Leu Leu Gly Leu 
        195                 200                 205             


Gly Val Leu Leu Phe Ser Gly Gly Leu Ser Glu Ser Glu Thr Gly Pro 
    210                 215                 220                 


Met Glu Glu Val Glu Arg Gln Val Leu Pro Asp Pro Glu Val Leu Glu 
225                 230                 235                 240 


Ala Val Gly Asp Arg Gln Asp Gly Leu Arg Glu Gln Leu Gln Ala Pro 
                245                 250                 255     


Val Pro Pro Asp Ser Val Pro Ser Leu Gln Asn Met Gly Leu Leu Leu 
            260                 265                 270         


Asp Lys Leu Ala Lys Glu Asn Gln Asp Ile Arg Leu Leu Gln Ala Gln 
        275                 280                 285             


Leu Gln Ala Gln Lys Glu Glu Leu Gln Ser Leu Met His Gln Pro Lys 
    290                 295                 300                 


Gly Leu Glu Glu Glu Asn Ala Gln Leu Arg Gly Ala Leu Gln Gln Gly 
305                 310                 315                 320 


Glu Ala Phe Gln Arg Ala Leu Glu Ser Glu Leu Gln Gln Leu Arg Ala 
                325                 330                 335     


Arg Leu Gln Gly Leu Glu Ala Asp Cys Val Arg Gly Pro Asp Gly Val 
            340                 345                 350         


Cys Leu Ser Gly Gly Arg Gly Pro Gln Gly Asp Lys Ala Ile Arg Glu 
        355                 360                 365             


Gln Gly Pro Arg Glu Gln Glu Pro Glu Leu Ser Phe Leu Lys Gln Lys 
    370                 375                 380                 


Glu Gln Leu Glu Ala Glu Ala Gln Ala Leu Arg Gln Glu Leu Glu Arg 
385                 390                 395                 400 


Gln Arg Arg Leu Leu Gly Ser Val Gln Gln Asp Leu Glu Arg Ser Leu 
                405                 410                 415     


Gln Asp Ala Ser Arg Gly Asp Pro Ala His Ala Gly Leu Ala Glu Leu 
            420                 425                 430         


Gly His Arg Leu Ala Gln Lys Leu Gln Gly Leu Glu Asn Trp Gly Gln 
        435                 440                 445             


Asp Pro Gly Val Ser Ala Asn Ala Ser Lys Ala Trp His Gln Lys Ser 
    450                 455                 460                 


His Phe Gln Asn Ser Arg Glu Trp Ser Gly Lys Glu Lys Trp Trp Asp 
465                 470                 475                 480 


Gly Gln Arg Asp Arg Lys Ala Glu His Trp Lys His Lys Lys Glu Glu 
                485                 490                 495     


Ser Gly Arg Glu Arg Lys Lys Asn Trp Gly Gly Gln Glu Asp Arg Glu 
            500                 505                 510         


Pro Ala Gly Arg Trp Lys Glu Gly Arg Pro Arg Val Glu Glu Ser Gly 
        515                 520                 525             


Ser Lys Lys Glu Gly Lys Arg Gln Gly Pro Lys Glu Pro Pro Arg Lys 
    530                 535                 540                 


Ser Gly Ser Phe His Ser Ser Gly Glu Lys Gln Lys Gln Pro Arg Trp 
545                 550                 555                 560 


Arg Glu Gly Thr Lys Asp Ser His Asp Pro Leu Pro Ser Trp Ala Glu 
                565                 570                 575     


Leu Leu Arg Pro Lys Tyr Arg Ala Pro Gln Gly Cys Ser Gly Val Asp 
            580                 585                 590         


Glu Cys Ala Arg Gln Glu Gly Leu Thr Phe Phe Gly Thr Glu Leu Ala 
        595                 600                 605             


Pro Val Arg Gln Gln Glu Leu Ala Ser Leu Leu Arg Thr Tyr Leu Ala 
    610                 615                 620                 


Arg Leu Pro Trp Ala Gly Gln Leu Thr Lys Glu Leu Pro Leu Ser Pro 
625                 630                 635                 640 


Ala Phe Phe Gly Glu Asp Gly Ile Phe Arg His Asp Arg Leu Arg Phe 
                645                 650                 655     


Arg Asp Phe Val Asp Ala Leu Glu Asp Ser Leu Glu Glu Val Ala Val 
            660                 665                 670         


Gln Gln Thr Gly Asp Asp Asp Glu Val Asp Asp Phe Glu Asp Phe Ile 
        675                 680                 685             


Phe Ser His Phe Phe Gly Asp Lys Ala Leu Lys Lys Arg Ser Gly Lys 
    690                 695                 700                 


Lys Asp Lys His Ser Gln Ser Pro Arg Ala Ala Gly Pro Arg Glu Gly 
705                 710                 715                 720 


His Ser His Ser His His His His His Arg Gly 
                725                 730     


<210>  58
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Arg Arg Ala Pro Ala Ala Glu Arg Leu Leu Glu Leu Gly Phe Pro 
1               5                   10                  15      


Pro Arg Cys Gly Arg Gln Glu Pro Pro Phe Pro Leu Gly Val Thr Arg 
            20                  25                  30          


Gly Trp Gly Arg Trp Pro Ile Gln Lys Arg Arg Glu Gly Ala Arg Pro 
        35                  40                  45              


Val Pro Phe Ser Glu Arg Ser Gln Glu Asp Gly Arg Gly Pro Ala Ala 
    50                  55                  60                  


Arg Ser Ser Gly Thr Leu Trp Arg Ile Arg Thr Arg Leu Ser Leu Cys 
65                  70                  75                  80  


Arg Asp Pro Glu Pro Pro Pro Pro Leu Cys Leu Leu Arg Val Ser Leu 
                85                  90                  95      


Leu Cys Ala Leu Arg Ala Gly Gly Arg Gly Ser Arg Trp Gly Glu Asp 
            100                 105                 110         


Gly Ala Arg Leu Leu Leu Leu Pro Pro Ala Arg Ala Ala Gly Asn Gly 
        115                 120                 125             


Glu Ala Glu Pro Ser Gly Gly Pro Ser Tyr Ala Gly Arg Met Leu Glu 
    130                 135                 140                 


Ser Ser Gly Cys Lys Ala Leu Lys Glu Gly Val Leu Glu Lys Arg Ser 
145                 150                 155                 160 


Asp Gly Leu Leu Gln Leu Trp Lys Lys Lys Cys Cys Ile Leu Thr Glu 
                165                 170                 175     


Glu Gly Leu Leu Leu Ile Pro Pro Lys Gln Leu Gln His Gln Gln Gln 
            180                 185                 190         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Gly Gln Gly 
        195                 200                 205             


Pro Ala Glu Pro Ser Gln Pro Ser Gly Pro Ala Val Ala Ser Leu Glu 
    210                 215                 220                 


Pro Pro Val Lys Leu Lys Glu Leu His Phe Ser Asn Met Lys Thr Val 
225                 230                 235                 240 


Asp Cys Val Glu Arg Lys Gly Lys Tyr Met Tyr Phe Thr Val Val Met 
                245                 250                 255     


Ala Glu Gly Lys Glu Ile Asp Phe Arg Cys Pro Gln Asp Gln Gly Trp 
            260                 265                 270         


Asn Ala Glu Ile Thr Leu Gln Met Val Gln Tyr Lys Asn Arg Gln Ala 
        275                 280                 285             


Ile Leu Ala Val Lys Ser Thr Arg Gln Lys Gln Gln His Leu Val Gln 
    290                 295                 300                 


Gln Gln Pro Pro Ser Gln Pro Gln Pro Gln Pro Gln Leu Gln Pro Gln 
305                 310                 315                 320 


Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln Ser Gln Pro Gln 
                325                 330                 335     


Pro Gln Pro Gln Pro Lys Pro Gln Pro Gln Gln Leu His Pro Tyr Pro 
            340                 345                 350         


His Pro His Pro His Pro His Ser His Pro His Ser His Pro His Pro 
        355                 360                 365             


His Pro His Pro His Pro His Gln Ile Pro His Pro His Pro Gln Pro 
    370                 375                 380                 


His Ser Gln Pro His Gly His Arg Leu Leu Arg Ser Thr Ser Asn Ser 
385                 390                 395                 400 


Ala 
    


<210>  59
<211>  1659
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Glu Ala Pro Ser Gly Ser Glu Pro Gly Gly Asp Gly Ala Gly Asp 
1               5                   10                  15      


Cys Ala His Pro Asp Pro Arg Ala Pro Gly Ala Ala Ala Pro Ser Ser 
            20                  25                  30          


Gly Pro Gly Pro Cys Ala Ala Ala Arg Glu Ser Glu Arg Gln Leu Arg 
        35                  40                  45              


Leu Arg Leu Cys Val Leu Asn Glu Ile Leu Gly Thr Glu Arg Asp Tyr 
    50                  55                  60                  


Val Gly Thr Leu Arg Phe Leu Gln Ser Ala Phe Leu His Arg Ile Arg 
65                  70                  75                  80  


Gln Asn Val Ala Asp Ser Val Glu Lys Gly Leu Thr Glu Glu Asn Val 
                85                  90                  95      


Lys Val Leu Phe Ser Asn Ile Glu Asp Ile Leu Glu Val His Lys Asp 
            100                 105                 110         


Phe Leu Ala Ala Leu Glu Tyr Cys Leu His Pro Glu Pro Gln Ser Gln 
        115                 120                 125             


His Glu Leu Gly Asn Val Phe Leu Lys Phe Lys Asp Lys Phe Cys Val 
    130                 135                 140                 


Tyr Glu Glu Tyr Cys Ser Asn His Glu Lys Ala Leu Arg Leu Leu Val 
145                 150                 155                 160 


Glu Leu Asn Lys Ile Pro Thr Val Arg Ala Phe Leu Leu Ser Cys Met 
                165                 170                 175     


Leu Leu Gly Gly Arg Lys Thr Thr Asp Ile Pro Leu Glu Gly Tyr Leu 
            180                 185                 190         


Leu Ser Pro Ile Gln Arg Ile Cys Lys Tyr Pro Leu Leu Leu Lys Glu 
        195                 200                 205             


Leu Ala Lys Arg Thr Pro Gly Lys His Pro Asp His Pro Ala Val Gln 
    210                 215                 220                 


Ser Ala Leu Gln Ala Met Lys Thr Val Cys Ser Asn Ile Asn Glu Thr 
225                 230                 235                 240 


Lys Arg Gln Met Glu Lys Leu Glu Ala Leu Glu Gln Leu Gln Ser His 
                245                 250                 255     


Ile Glu Gly Trp Glu Gly Ser Asn Leu Thr Asp Ile Cys Thr Gln Leu 
            260                 265                 270         


Leu Leu Gln Gly Thr Leu Leu Lys Ile Ser Ala Gly Asn Ile Gln Glu 
        275                 280                 285             


Arg Ala Phe Phe Leu Phe Asp Asn Leu Leu Val Tyr Cys Lys Arg Lys 
    290                 295                 300                 


Ser Arg Val Thr Gly Ser Lys Lys Ser Thr Lys Arg Thr Lys Ser Ile 
305                 310                 315                 320 


Asn Gly Ser Leu Tyr Ile Phe Arg Gly Arg Ile Asn Thr Glu Val Met 
                325                 330                 335     


Glu Val Glu Asn Val Glu Asp Gly Thr Ala Asp Tyr His Ser Asn Gly 
            340                 345                 350         


Tyr Thr Val Thr Asn Gly Trp Lys Ile His Asn Thr Ala Lys Asn Lys 
        355                 360                 365             


Trp Phe Val Cys Met Ala Lys Thr Ala Glu Glu Lys Gln Lys Trp Leu 
    370                 375                 380                 


Asp Ala Ile Ile Arg Glu Arg Glu Gln Arg Glu Ser Leu Lys Leu Gly 
385                 390                 395                 400 


Met Glu Arg Asp Ala Tyr Val Met Ile Ala Glu Lys Gly Glu Lys Leu 
                405                 410                 415     


Tyr His Met Met Met Asn Lys Lys Val Asn Leu Ile Lys Asp Arg Arg 
            420                 425                 430         


Arg Lys Leu Ser Thr Val Pro Lys Cys Phe Leu Gly Asn Glu Phe Val 
        435                 440                 445             


Ala Trp Leu Leu Glu Ile Gly Glu Ile Ser Lys Thr Glu Glu Gly Val 
    450                 455                 460                 


Asn Leu Gly Gln Ala Leu Leu Glu Asn Gly Ile Ile His His Val Ser 
465                 470                 475                 480 


Asp Lys His Gln Phe Lys Asn Glu Gln Val Met Tyr Arg Phe Arg Tyr 
                485                 490                 495     


Asp Asp Gly Thr Tyr Lys Ala Arg Ser Glu Leu Glu Asp Ile Met Ser 
            500                 505                 510         


Lys Gly Val Arg Leu Tyr Cys Arg Leu His Ser Leu Tyr Thr Pro Val 
        515                 520                 525             


Ile Lys Asp Arg Asp Tyr His Leu Lys Thr Tyr Lys Ser Val Leu Pro 
    530                 535                 540                 


Gly Ser Lys Leu Val Asp Trp Leu Leu Ala Gln Gly Asp Cys Gln Thr 
545                 550                 555                 560 


Arg Glu Glu Ala Val Ala Leu Gly Val Gly Leu Cys Asn Asn Gly Phe 
                565                 570                 575     


Met His His Val Leu Glu Lys Ser Glu Phe Arg Asp Glu Ser Gln Tyr 
            580                 585                 590         


Phe Arg Phe His Ala Asp Glu Glu Met Glu Gly Thr Ser Ser Lys Asn 
        595                 600                 605             


Lys Gln Leu Arg Asn Asp Phe Lys Leu Val Glu Asn Ile Leu Ala Lys 
    610                 615                 620                 


Arg Leu Leu Ile Leu Pro Gln Glu Glu Asp Tyr Gly Phe Asp Ile Glu 
625                 630                 635                 640 


Glu Lys Asn Lys Ala Val Val Val Lys Ser Val Gln Arg Gly Ser Leu 
                645                 650                 655     


Ala Glu Val Ala Gly Leu Gln Val Gly Arg Lys Ile Tyr Ser Ile Asn 
            660                 665                 670         


Glu Asp Leu Val Phe Leu Arg Pro Phe Ser Glu Val Glu Ser Ile Leu 
        675                 680                 685             


Asn Gln Ser Phe Cys Ser Arg Arg Pro Leu Arg Leu Leu Val Ala Thr 
    690                 695                 700                 


Lys Ala Lys Glu Ile Ile Lys Ile Pro Asp Gln Pro Asp Thr Leu Cys 
705                 710                 715                 720 


Phe Gln Ile Arg Gly Ala Ala Pro Pro Tyr Val Tyr Ala Val Gly Arg 
                725                 730                 735     


Gly Ser Glu Ala Met Ala Ala Gly Leu Cys Ala Gly Gln Cys Ile Leu 
            740                 745                 750         


Lys Val Asn Gly Ser Asn Val Met Asn Asp Gly Ala Pro Glu Val Leu 
        755                 760                 765             


Glu His Phe Gln Ala Phe Arg Ser Arg Arg Glu Glu Ala Leu Gly Leu 
    770                 775                 780                 


Tyr Gln Trp Ile Tyr His Thr His Glu Asp Ala Gln Glu Ala Arg Ala 
785                 790                 795                 800 


Ser Gln Glu Ala Ser Thr Glu Asp Pro Ser Gly Glu Gln Ala Gln Glu 
                805                 810                 815     


Glu Asp Gln Ala Asp Ser Ala Phe Pro Leu Leu Ser Leu Gly Pro Arg 
            820                 825                 830         


Leu Ser Leu Cys Glu Asp Ser Pro Met Val Thr Leu Thr Val Asp Asn 
        835                 840                 845             


Val His Leu Glu His Gly Val Val Tyr Glu Tyr Val Ser Thr Ala Gly 
    850                 855                 860                 


Val Arg Cys His Val Leu Glu Lys Ile Val Glu Pro Arg Gly Cys Phe 
865                 870                 875                 880 


Gly Leu Thr Ala Lys Ile Leu Glu Ala Phe Ala Ala Asn Asp Ser Val 
                885                 890                 895     


Phe Val Glu Asn Cys Arg Arg Leu Met Ala Leu Ser Ser Ala Ile Val 
            900                 905                 910         


Thr Met Pro His Phe Glu Phe Arg Asn Ile Cys Asp Thr Lys Leu Glu 
        915                 920                 925             


Ser Ile Gly Gln Arg Ile Ala Cys Tyr Gln Glu Phe Ala Ala Gln Leu 
    930                 935                 940                 


Lys Ser Arg Val Ser Pro Pro Phe Lys Gln Ala Pro Leu Glu Pro His 
945                 950                 955                 960 


Pro Leu Cys Gly Leu Asp Phe Cys Pro Thr Asn Cys His Ile Asn Leu 
                965                 970                 975     


Met Glu Val Ser Tyr Pro Lys Thr Thr Pro Ser Val Gly Arg Ser Phe 
            980                 985                 990         


Ser Ile Arg Phe Gly Arg Lys Pro  Ser Leu Ile Gly Leu  Asp Pro Glu 
        995                 1000                 1005             


Gln Gly  His Leu Asn Pro Met  Ser Tyr Thr Gln His  Cys Ile Thr 
    1010                 1015                 1020             


Thr Met  Ala Ala Pro Ser Trp  Lys Cys Leu Pro Ala  Ala Glu Gly 
    1025                 1030                 1035             


Asp Pro  Gln Gly Gln Gly Leu  His Asp Gly Ser Phe  Gly Pro Ala 
    1040                 1045                 1050             


Ser Gly  Thr Leu Gly Gln Glu  Asp Arg Gly Leu Ser  Phe Leu Leu 
    1055                 1060                 1065             


Lys Gln  Glu Asp Arg Glu Ile  Gln Asp Ala Tyr Leu  Gln Leu Phe 
    1070                 1075                 1080             


Thr Lys  Leu Asp Val Ala Leu  Lys Glu Met Lys Gln  Tyr Val Thr 
    1085                 1090                 1095             


Gln Ile  Asn Arg Leu Leu Ser  Thr Ile Thr Glu Pro  Thr Ser Gly 
    1100                 1105                 1110             


Gly Ser  Cys Asp Ala Ser Leu  Ala Glu Glu Ala Ser  Ser Leu Pro 
    1115                 1120                 1125             


Leu Val  Ser Glu Glu Ser Glu  Met Asp Arg Ser Asp  His Gly Gly 
    1130                 1135                 1140             


Ile Lys  Lys Val Cys Phe Lys  Val Ala Glu Glu Asp  Gln Glu Asp 
    1145                 1150                 1155             


Ser Gly  His Asp Thr Met Ser  Tyr Arg Asp Ser Tyr  Ser Glu Cys 
    1160                 1165                 1170             


Asn Ser  Asn Arg Asp Ser Val  Leu Ser Tyr Thr Ser  Val Arg Ser 
    1175                 1180                 1185             


Asn Ser  Ser Tyr Leu Gly Ser  Asp Glu Met Gly Ser  Gly Asp Glu 
    1190                 1195                 1200             


Leu Pro  Cys Asp Met Arg Ile  Pro Ser Asp Lys Gln  Asp Lys Leu 
    1205                 1210                 1215             


His Gly  Cys Leu Glu His Leu  Phe Asn Gln Val Asp  Ser Ile Asn 
    1220                 1225                 1230             


Ala Leu  Leu Lys Gly Pro Val  Met Ser Arg Ala Phe  Glu Glu Thr 
    1235                 1240                 1245             


Lys His  Phe Pro Met Asn His  Ser Leu Gln Glu Phe  Lys Gln Lys 
    1250                 1255                 1260             


Glu Glu  Cys Thr Ile Arg Gly  Arg Ser Leu Ile Gln  Ile Ser Ile 
    1265                 1270                 1275             


Gln Glu  Asp Pro Trp Asn Leu  Pro Asn Ser Ile Lys  Thr Leu Val 
    1280                 1285                 1290             


Asp Asn  Ile Gln Arg Tyr Val  Glu Asp Gly Lys Asn  Gln Leu Leu 
    1295                 1300                 1305             


Leu Ala  Leu Leu Lys Cys Thr  Asp Thr Glu Leu Gln  Leu Arg Arg 
    1310                 1315                 1320             


Asp Ala  Ile Phe Cys Gln Ala  Leu Val Ala Ala Val  Cys Thr Phe 
    1325                 1330                 1335             


Ser Lys  Gln Leu Leu Ala Ala  Leu Gly Tyr Arg Tyr  Asn Asn Asn 
    1340                 1345                 1350             


Gly Glu  Tyr Glu Glu Ser Ser  Arg Asp Ala Ser Arg  Lys Trp Leu 
    1355                 1360                 1365             


Glu Gln  Val Ala Ala Thr Gly  Val Leu Leu His Cys  Gln Ser Leu 
    1370                 1375                 1380             


Leu Ser  Pro Ala Thr Val Lys  Glu Glu Arg Thr Met  Leu Glu Asp 
    1385                 1390                 1395             


Ile Trp  Val Thr Leu Ser Glu  Leu Asp Asn Val Thr  Phe Ser Phe 
    1400                 1405                 1410             


Lys Gln  Leu Asp Glu Asn Tyr  Val Ala Asn Thr Asn  Val Phe Tyr 
    1415                 1420                 1425             


His Ile  Glu Gly Ser Arg Gln  Ala Leu Lys Val Ile  Phe Tyr Leu 
    1430                 1435                 1440             


Asp Ser  Tyr His Phe Ser Lys  Leu Pro Ser Arg Leu  Glu Gly Gly 
    1445                 1450                 1455             


Ala Ser  Leu Arg Leu His Thr  Ala Leu Phe Thr Lys  Val Leu Glu 
    1460                 1465                 1470             


Asn Val  Glu Gly Leu Pro Ser  Pro Gly Ser Gln Ala  Ala Glu Asp 
    1475                 1480                 1485             


Leu Gln  Gln Asp Ile Asn Ala  Gln Ser Leu Glu Lys  Val Gln Gln 
    1490                 1495                 1500             


Tyr Tyr  Arg Lys Leu Arg Ala  Phe Tyr Leu Glu Arg  Ser Asn Leu 
    1505                 1510                 1515             


Pro Thr  Asp Ala Ser Thr Thr  Ala Val Lys Ile Asp  Gln Leu Ile 
    1520                 1525                 1530             


Arg Pro  Ile Asn Ala Leu Asp  Glu Leu Cys Arg Leu  Met Lys Ser 
    1535                 1540                 1545             


Phe Val  His Pro Lys Pro Gly  Ala Ala Gly Ser Val  Gly Ala Gly 
    1550                 1555                 1560             


Leu Ile  Pro Ile Ser Ser Glu  Leu Cys Tyr Arg Leu  Gly Ala Cys 
    1565                 1570                 1575             


Gln Met  Val Met Cys Gly Thr  Gly Met Gln Arg Ser  Thr Leu Ser 
    1580                 1585                 1590             


Val Ser  Leu Glu Gln Ala Ala  Ile Leu Ala Arg Ser  His Gly Leu 
    1595                 1600                 1605             


Leu Pro  Lys Cys Ile Met Gln  Ala Thr Asp Ile Met  Arg Lys Gln 
    1610                 1615                 1620             


Gly Pro  Arg Val Glu Ile Leu  Ala Lys Asn Leu Arg  Val Lys Asp 
    1625                 1630                 1635             


Gln Met  Pro Gln Gly Ala Pro  Arg Leu Tyr Arg Leu  Cys Gln Pro 
    1640                 1645                 1650             


Pro Val  Asp Gly Asp Leu 
    1655                 


<210>  60
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Pro Ala His Ser Leu Val Met Ser Ser Pro Ala Leu Pro Ala Phe 
1               5                   10                  15      


Leu Leu Cys Ser Thr Leu Leu Val Ile Lys Met Tyr Val Val Ala Ile 
            20                  25                  30          


Ile Thr Gly Gln Val Arg Leu Arg Lys Lys Ala Phe Ala Asn Pro Glu 
        35                  40                  45              


Asp Ala Leu Arg His Gly Gly Pro Gln Tyr Cys Arg Ser Asp Pro Asp 
    50                  55                  60                  


Val Glu Arg Cys Leu Arg Ala His Arg Asn Asp Met Glu Thr Ile Tyr 
65                  70                  75                  80  


Pro Phe Leu Phe Leu Gly Phe Val Tyr Ser Phe Leu Gly Pro Asn Pro 
                85                  90                  95      


Phe Val Ala Trp Met His Phe Leu Val Phe Leu Val Gly Arg Val Ala 
            100                 105                 110         


His Thr Val Ala Tyr Leu Gly Lys Leu Arg Ala Pro Ile Arg Ser Val 
        115                 120                 125             


Thr Tyr Thr Leu Ala Gln Leu Pro Cys Ala Ser Met Ala Leu Gln Ile 
    130                 135                 140                 


Leu Trp Glu Ala Ala Arg His Leu 
145                 150         


<210>  61
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Leu Ala Arg Ala Leu Leu Leu Cys Ala Val Leu Ala Leu Ser His 
1               5                   10                  15      


Thr Ala Asn Pro Cys Cys Ser His Pro Cys Gln Asn Arg Gly Val Cys 
            20                  25                  30          


Met Ser Val Gly Phe Asp Gln Tyr Lys Cys Asp Cys Thr Arg Thr Gly 
        35                  40                  45              


Phe Tyr Gly Glu Asn Cys Ser Thr Pro Glu Phe Leu Thr Arg Ile Lys 
    50                  55                  60                  


Leu Phe Leu Lys Pro Thr Pro Asn Thr Val His Tyr Ile Leu Thr His 
65                  70                  75                  80  


Phe Lys Gly Phe Trp Asn Val Val Asn Asn Ile Pro Phe Leu Arg Asn 
                85                  90                  95      


Ala Ile Met Ser Tyr Val Leu Thr Ser Arg Ser His Leu Ile Asp Ser 
            100                 105                 110         


Pro Pro Thr Tyr Asn Ala Asp Tyr Gly Tyr Lys Ser Trp Glu Ala Phe 
        115                 120                 125             


Ser Asn Leu Ser Tyr Tyr Thr Arg Ala Leu Pro Pro Val Pro Asp Asp 
    130                 135                 140                 


Cys Pro Thr Pro Leu Gly Val Lys Gly Lys Lys Gln Leu Pro Asp Ser 
145                 150                 155                 160 


Asn Glu Ile Val Glu Lys Leu Leu Leu Arg Arg Lys Phe Ile Pro Asp 
                165                 170                 175     


Pro Gln Gly Ser Asn Met Met Phe Ala Phe Phe Ala Gln His Phe Thr 
            180                 185                 190         


His Gln Phe Phe Lys Thr Asp His Lys Arg Gly Pro Ala Phe Thr Asn 
        195                 200                 205             


Gly Leu Gly His Gly Val Asp Leu Asn His Ile Tyr Gly Glu Thr Leu 
    210                 215                 220                 


Ala Arg Gln Arg Lys Leu Arg Leu Phe Lys Asp Gly Lys Met Lys Tyr 
225                 230                 235                 240 


Gln Ile Ile Asp Gly Glu Met Tyr Pro Pro Thr Val Lys Asp Thr Gln 
                245                 250                 255     


Ala Glu Met Ile Tyr Pro Pro Gln Val Pro Glu His Leu Arg Phe Ala 
            260                 265                 270         


Val Gly Gln Glu Val Phe Gly Leu Val Pro Gly Leu Met Met Tyr Ala 
        275                 280                 285             


Thr Ile Trp Leu Arg Glu His Asn Arg Val Cys Asp Val Leu Lys Gln 
    290                 295                 300                 


Glu His Pro Glu Trp Gly Asp Glu Gln Leu Phe Gln Thr Ser Arg Leu 
305                 310                 315                 320 


Ile Leu Ile Gly Glu Thr Ile Lys Ile Val Ile Glu Asp Tyr Val Gln 
                325                 330                 335     


His Leu Ser Gly Tyr His Phe Lys Leu Lys Phe Asp Pro Glu Leu Leu 
            340                 345                 350         


Phe Asn Lys Gln Phe Gln Tyr Gln Asn Arg Ile Ala Ala Glu Phe Asn 
        355                 360                 365             


Thr Leu Tyr His Trp His Pro Leu Leu Pro Asp Thr Phe Gln Ile His 
    370                 375                 380                 


Asp Gln Lys Tyr Asn Tyr Gln Gln Phe Ile Tyr Asn Asn Ser Ile Leu 
385                 390                 395                 400 


Leu Glu His Gly Ile Thr Gln Phe Val Glu Ser Phe Thr Arg Gln Ile 
                405                 410                 415     


Ala Gly Arg Val Ala Gly Gly Arg Asn Val Pro Pro Ala Val Gln Lys 
            420                 425                 430         


Val Ser Gln Ala Ser Ile Asp Gln Ser Arg Gln Met Lys Tyr Gln Ser 
        435                 440                 445             


Phe Asn Glu Tyr Arg Lys Arg Phe Met Leu Lys Pro Tyr Glu Ser Phe 
    450                 455                 460                 


Glu Glu Leu Thr Gly Glu Lys Glu Met Ser Ala Glu Leu Glu Ala Leu 
465                 470                 475                 480 


Tyr Gly Asp Ile Asp Ala Val Glu Leu Tyr Pro Ala Leu Leu Val Glu 
                485                 490                 495     


Lys Pro Arg Pro Asp Ala Ile Phe Gly Glu Thr Met Val Glu Val Gly 
            500                 505                 510         


Ala Pro Phe Ser Leu Lys Gly Leu Met Gly Asn Val Ile Cys Ser Pro 
        515                 520                 525             


Ala Tyr Trp Lys Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Gln Ile 
    530                 535                 540                 


Ile Asn Thr Ala Ser Ile Gln Ser Leu Ile Cys Asn Asn Val Lys Gly 
545                 550                 555                 560 


Cys Pro Phe Thr Ser Phe Ser Val Pro Asp Pro Glu Leu Ile Lys Thr 
                565                 570                 575     


Val Thr Ile Asn Ala Ser Ser Ser Arg Ser Gly Leu Asp Asp Ile Asn 
            580                 585                 590         


Pro Thr Val Leu Leu Lys Glu Arg Ser Thr Glu Leu 
        595                 600                 


<210>  62
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Thr Asp Gly Asp Tyr Asp Tyr Leu Ile Lys Leu Leu Ala Leu Gly 
1               5                   10                  15      


Asp Ser Gly Val Gly Lys Thr Thr Phe Leu Tyr Arg Tyr Thr Asp Asn 
            20                  25                  30          


Lys Phe Asn Pro Lys Phe Ile Thr Thr Val Gly Ile Asp Phe Arg Glu 
        35                  40                  45              


Lys Arg Val Val Tyr Asn Ala Gln Gly Pro Asn Gly Ser Ser Gly Lys 
    50                  55                  60                  


Ala Phe Lys Val His Leu Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg 
65                  70                  75                  80  


Phe Arg Ser Leu Thr Thr Ala Phe Phe Arg Asp Ala Met Gly Phe Leu 
                85                  90                  95      


Leu Met Phe Asp Leu Thr Ser Gln Gln Ser Phe Leu Asn Val Arg Asn 
            100                 105                 110         


Trp Met Ser Gln Leu Gln Ala Asn Ala Tyr Cys Glu Asn Pro Asp Ile 
        115                 120                 125             


Val Leu Ile Gly Asn Lys Ala Asp Leu Pro Asp Gln Arg Glu Val Asn 
    130                 135                 140                 


Glu Arg Gln Ala Arg Glu Leu Ala Asp Lys Tyr Gly Ile Pro Tyr Phe 
145                 150                 155                 160 


Glu Thr Ser Ala Ala Thr Gly Gln Asn Val Glu Lys Ala Val Glu Thr 
                165                 170                 175     


Leu Leu Asp Leu Ile Met Lys Arg Met Glu Gln Cys Val Glu Lys Thr 
            180                 185                 190         


Gln Ile Pro Asp Thr Val Asn Gly Gly Asn Ser Gly Asn Leu Asp Gly 
        195                 200                 205             


Glu Lys Pro Pro Glu Lys Lys Cys Ile Cys 
    210                 215             


<210>  63
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ala Ala Ile Arg Lys Lys Leu Val Val Val Gly Asp Gly Ala Cys 
1               5                   10                  15      


Gly Lys Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Glu Phe Pro Glu 
            20                  25                  30          


Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Val Ala Asp Ile Glu Val 
        35                  40                  45              


Asp Gly Lys Gln Val Glu Leu Ala Leu Trp Asp Thr Ala Gly Gln Glu 
    50                  55                  60                  


Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Asp Thr Asp Val Ile 
65                  70                  75                  80  


Leu Met Cys Phe Ser Val Asp Ser Pro Asp Ser Leu Glu Asn Ile Pro 
                85                  90                  95      


Glu Lys Trp Val Pro Glu Val Lys His Phe Cys Pro Asn Val Pro Ile 
            100                 105                 110         


Ile Leu Val Ala Asn Lys Lys Asp Leu Arg Ser Asp Glu His Val Arg 
        115                 120                 125             


Thr Glu Leu Ala Arg Met Lys Gln Glu Pro Val Arg Thr Asp Asp Gly 
    130                 135                 140                 


Arg Ala Met Ala Val Arg Ile Gln Ala Tyr Asp Tyr Leu Glu Cys Ser 
145                 150                 155                 160 


Ala Lys Thr Lys Glu Gly Val Arg Glu Val Phe Glu Thr Ala Thr Arg 
                165                 170                 175     


Ala Ala Leu Gln Lys Arg Tyr Gly Ser Gln Asn Gly Cys Ile Asn Cys 
            180                 185                 190         


Cys Lys Val Leu 
        195     


<210>  64
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Val Ala Pro Gly Leu Val Leu Gly Leu Val Leu Pro Leu Ile Leu 
1               5                   10                  15      


Trp Ala Asp Arg Ser Ala Gly Ile Gly Phe Arg Phe Ala Ser Tyr Ile 
            20                  25                  30          


Asn Asn Asp Met Val Leu Gln Lys Glu Pro Ala Gly Ala Val Ile Trp 
        35                  40                  45              


Gly Phe Gly Thr Pro Gly Ala Thr Val Thr Val Thr Leu Arg Gln Gly 
    50                  55                  60                  


Gln Glu Thr Ile Met Lys Lys Val Thr Ser Val Lys Ala His Ser Asp 
65                  70                  75                  80  


Thr Trp Met Val Val Leu Asp Pro Met Lys Pro Gly Gly Pro Phe Glu 
                85                  90                  95      


Val Met Ala Gln Gln Thr Leu Glu Lys Ile Asn Phe Thr Leu Arg Val 
            100                 105                 110         


His Asp Val Leu Phe Gly Asp Val Trp Leu Cys Ser Gly Gln Ser Asn 
        115                 120                 125             


Met Gln Met Thr Val Leu Gln Ile Phe Asn Ala Thr Arg Glu Leu Ser 
    130                 135                 140                 


Asn Thr Ala Ala Tyr Gln Ser Val Arg Ile Leu Ser Val Ser Pro Ile 
145                 150                 155                 160 


Gln Ala Glu Gln Glu Leu Glu Asp Leu Val Ala Val Asp Leu Gln Trp 
                165                 170                 175     


Ser Lys Pro Thr Ser Glu Asn Leu Gly His Gly Tyr Phe Lys Tyr Met 
            180                 185                 190         


Ser Ala Val Cys Trp Leu Phe Gly Arg His Leu Tyr Asp Thr Leu Gln 
        195                 200                 205             


Tyr Pro Ile Gly Leu Ile Ala Ser Ser Trp Gly Gly Thr Pro Ile Glu 
    210                 215                 220                 


Ala Trp Ser Ser Gly Arg Ser Leu Lys Ala Cys Gly Val Pro Lys Gln 
225                 230                 235                 240 


Gly Ser Ile Pro Tyr Asp Ser Val Thr Gly Pro Ser Lys His Ser Val 
                245                 250                 255     


Leu Trp Asn Ala Met Ile His Pro Leu Cys Asn Met Thr Leu Lys Gly 
            260                 265                 270         


Val Val Trp Tyr Gln Gly Glu Ser Asn Ile Asn Tyr Asn Thr Asp Leu 
        275                 280                 285             


Tyr Asn Cys Thr Phe Pro Ala Leu Ile Glu Asp Trp Arg Glu Thr Phe 
    290                 295                 300                 


His Arg Gly Ser Gln Gly Gln Thr Glu Arg Phe Phe Pro Phe Gly Leu 
305                 310                 315                 320 


Val Gln Leu Ser Ser Asp Leu Ser Lys Lys Ser Ser Asp Asp Gly Phe 
                325                 330                 335     


Pro Gln Ile Arg Trp His Gln Thr Ala Asp Phe Gly Tyr Val Pro Asn 
            340                 345                 350         


Pro Lys Met Pro Asn Thr Phe Met Ala Val Ala Met Asp Leu Cys Asp 
        355                 360                 365             


Arg Asp Ser Pro Phe Gly Ser Ile His Pro Arg Asp Lys Gln Thr Val 
    370                 375                 380                 


Ala Tyr Arg Leu His Leu Gly Ala Arg Ala Leu Ala Tyr Gly Glu Lys 
385                 390                 395                 400 


Asn Leu Thr Phe Glu Gly Pro Leu Pro Glu Lys Ile Glu Leu Leu Ala 
                405                 410                 415     


His Lys Gly Leu Leu Asn Leu Thr Tyr Tyr Gln Gln Ile Gln Val Gln 
            420                 425                 430         


Lys Lys Asp Asn Lys Ile Phe Glu Ile Ser Cys Cys Ser Asp His Arg 
        435                 440                 445             


Cys Lys Trp Leu Pro Ala Ser Met Asn Thr Val Ser Thr Gln Ser Leu 
    450                 455                 460                 


Thr Leu Ala Ile Asp Ser Cys His Gly Thr Val Val Ala Leu Arg Tyr 
465                 470                 475                 480 


Ala Trp Thr Thr Trp Pro Cys Glu Tyr Lys Gln Cys Pro Leu Tyr His 
                485                 490                 495     


Pro Ser Ser Ala Leu Pro Ala Pro Pro Phe Ile Ala Phe Ile Thr Asp 
            500                 505                 510         


Gln Gly Pro Gly His Gln Ser Asn Val Ala Lys 
        515                 520             


<210>  65
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Thr Gln Asn Lys Leu Lys Leu Cys Ser Lys Ala Asn Val Tyr Thr 
1               5                   10                  15      


Glu Val Pro Asp Gly Gly Trp Gly Trp Ala Val Ala Val Ser Phe Phe 
            20                  25                  30          


Phe Val Glu Val Phe Thr Tyr Gly Ile Ile Lys Thr Phe Gly Val Phe 
        35                  40                  45              


Phe Asn Asp Leu Met Asp Ser Phe Asn Glu Ser Asn Ser Arg Ile Ser 
    50                  55                  60                  


Trp Ile Ile Ser Ile Cys Val Phe Val Leu Thr Phe Ser Ala Pro Leu 
65                  70                  75                  80  


Ala Thr Val Leu Ser Asn Arg Phe Gly His Arg Leu Val Val Met Leu 
                85                  90                  95      


Gly Gly Leu Leu Val Ser Thr Gly Met Val Ala Ala Ser Phe Ser Gln 
            100                 105                 110         


Glu Val Ser His Met Tyr Val Ala Ile Gly Ile Ile Ser Gly Leu Gly 
        115                 120                 125             


Tyr Cys Phe Ser Phe Leu Pro Thr Val Thr Ile Leu Ser Gln Tyr Phe 
    130                 135                 140                 


Gly Lys Arg Arg Ser Ile Val Thr Ala Val Ala Ser Thr Gly Glu Cys 
145                 150                 155                 160 


Phe Ala Val Phe Ala Phe Ala Pro Ala Ile Met Ala Leu Lys Glu Arg 
                165                 170                 175     


Ile Gly Trp Arg Tyr Ser Leu Leu Phe Val Gly Leu Leu Gln Leu Asn 
            180                 185                 190         


Ile Val Ile Phe Gly Ala Leu Leu Arg Pro Ile Phe Ile Arg Gly Pro 
        195                 200                 205             


Ala Ser Pro Lys Ile Val Ile Gln Glu Asn Arg Lys Glu Ala Gln Tyr 
    210                 215                 220                 


Met Leu Glu Asn Glu Lys Thr Arg Thr Ser Ile Asp Ser Ile Asp Ser 
225                 230                 235                 240 


Gly Val Glu Leu Thr Thr Ser Pro Lys Asn Val Pro Thr His Thr Asn 
                245                 250                 255     


Leu Glu Leu Glu Pro Lys Ala Asp Met Gln Gln Val Leu Val Lys Thr 
            260                 265                 270         


Ser Pro Arg Pro Ser Glu Lys Lys Ala Pro Leu Leu Asp Phe Ser Ile 
        275                 280                 285             


Leu Lys Glu Lys Ser Phe Ile Cys Tyr Ala Leu Phe Gly Leu Phe Ala 
    290                 295                 300                 


Thr Leu Gly Phe Phe Ala Pro Ser Leu Tyr Ile Ile Pro Leu Gly Ile 
305                 310                 315                 320 


Ser Leu Gly Ile Asp Gln Asp Arg Ala Ala Phe Leu Leu Ser Thr Met 
                325                 330                 335     


Ala Ile Ala Glu Val Phe Gly Arg Ile Gly Ala Gly Phe Val Leu Asn 
            340                 345                 350         


Arg Glu Pro Ile Arg Lys Ile Tyr Ile Glu Leu Ile Cys Val Ile Leu 
        355                 360                 365             


Leu Thr Val Ser Leu Phe Ala Phe Thr Phe Ala Thr Glu Phe Trp Gly 
    370                 375                 380                 


Leu Met Ser Cys Ser Ile Phe Phe Gly Phe Met Val Gly Thr Ile Gly 
385                 390                 395                 400 


Gly Thr His Ile Pro Leu Leu Ala Glu Asp Asp Val Val Gly Ile Glu 
                405                 410                 415     


Lys Met Ser Ser Ala Ala Gly Val Tyr Ile Phe Ile Gln Ser Ile Ala 
            420                 425                 430         


Gly Leu Ala Gly Pro Pro Leu Ala Gly Leu Leu Val Asp Gln Ser Lys 
        435                 440                 445             


Ile Tyr Ser Arg Ala Phe Tyr Ser Cys Ala Ala Gly Met Ala Leu Ala 
    450                 455                 460                 


Ala Val Cys Leu Ala Leu Val Arg Pro Cys Lys Met Gly Leu Cys Gln 
465                 470                 475                 480 


His His His Ser Gly Glu Thr Lys Val Val Ser His Arg Gly Lys Thr 
                485                 490                 495     


Leu Gln Asp Ile Pro Glu Asp Phe Leu Glu Met Asp Leu Ala Lys Asn 
            500                 505                 510         


Glu His Arg Val His Val Gln Met Glu Pro Val 
        515                 520             


<210>  66
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Asp Pro Ala Arg Pro Leu Gly Leu Ser Ile Leu Leu Leu Phe Leu 
1               5                   10                  15      


Thr Glu Ala Ala Leu Gly Asp Ala Ala Gln Glu Pro Thr Gly Asn Asn 
            20                  25                  30          


Ala Glu Ile Cys Leu Leu Pro Leu Asp Tyr Gly Pro Cys Arg Ala Leu 
        35                  40                  45              


Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg Gln Phe 
    50                  55                  60                  


Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr Trp Glu 
65                  70                  75                  80  


Ala Cys Asp Asp Ala Cys Trp Arg Ile Glu Lys Val Pro Lys Val Cys 
                85                  90                  95      


Arg Leu Gln Val Ser Val Asp Asp Gln Cys Glu Gly Ser Thr Glu Lys 
            100                 105                 110         


Tyr Phe Phe Asn Leu Ser Ser Met Thr Cys Glu Lys Phe Phe Ser Gly 
        115                 120                 125             


Gly Cys His Arg Asn Arg Ile Glu Asn Arg Phe Pro Asp Glu Ala Thr 
    130                 135                 140                 


Cys Met Gly Phe Cys Ala Pro Lys Lys Ile Pro Ser Phe Cys Tyr Ser 
145                 150                 155                 160 


Pro Lys Asp Glu Gly Leu Cys Ser Ala Asn Val Thr Arg Tyr Tyr Phe 
                165                 170                 175     


Asn Pro Arg Tyr Arg Thr Cys Asp Ala Phe Thr Tyr Thr Gly Cys Gly 
            180                 185                 190         


Gly Asn Asp Asn Asn Phe Val Ser Arg Glu Asp Cys Lys Arg Ala Cys 
        195                 200                 205             


Ala Lys Ala Leu Lys Lys Lys Lys Lys Met Pro Lys Leu Arg Phe Ala 
    210                 215                 220                 


Ser Arg Ile Arg Lys Ile Arg Lys Lys Gln Phe 
225                 230                 235 


<210>  67
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Ser Arg Leu Leu Pro Leu Leu Arg Ser Arg Thr Ala Arg Ser Leu 
1               5                   10                  15      


Arg Pro Gly Pro Ala Ala Ala Ala Ala Pro Arg Pro Pro Ser Trp Cys 
            20                  25                  30          


Cys Cys Gly Arg Gly Leu Leu Ala Leu Ala Pro Pro Gly Gly Leu Pro 
        35                  40                  45              


Gly Gly Pro Arg Arg Leu Gly Thr His Pro Lys Lys Glu Pro Met Glu 
    50                  55                  60                  


Ala Leu Asn Thr Ala Gln Gly Ala Arg Asp Phe Ile Tyr Ser Leu His 
65                  70                  75                  80  


Ser Thr Glu Arg Ser Cys Leu Leu Lys Glu Leu His Arg Phe Glu Ser 
                85                  90                  95      


Ile Ala Ile Ala Gln Glu Lys Leu Glu Ala Pro Pro Pro Thr Pro Gly 
            100                 105                 110         


Gln Leu Arg Tyr Val Phe Ile His Asn Ala Ile Pro Phe Ile Gly Phe 
        115                 120                 125             


Gly Phe Leu Asp Asn Ala Ile Met Ile Val Ala Gly Thr His Ile Glu 
    130                 135                 140                 


Met Ser Ile Gly Ile Ile Leu Gly Ile Ser Thr Met Ala Ala Ala Ala 
145                 150                 155                 160 


Leu Gly Asn Leu Val Ser Asp Leu Ala Gly Leu Gly Leu Ala Gly Tyr 
                165                 170                 175     


Val Glu Ala Leu Ala Ser Arg Leu Gly Leu Ser Ile Pro Asp Leu Thr 
            180                 185                 190         


Pro Lys Gln Val Asp Met Trp Gln Thr Arg Leu Ser Thr His Leu Gly 
        195                 200                 205             


Lys Ala Val Gly Val Thr Ile Gly Cys Ile Leu Gly Met Phe Pro Leu 
    210                 215                 220                 


Ile Phe Phe Gly Gly Gly Glu Glu Asp Glu Lys Leu Glu Thr Lys Ser 
225                 230                 235                 240 


<210>  68
<211>  886
<212>  PRT
<213>  Homo sapiens

<400>  68

Met His Asp Ala Phe Glu Pro Val Pro Ile Leu Glu Lys Leu Pro Leu 
1               5                   10                  15      


Gln Ile Asp Cys Leu Ala Ala Trp Glu Glu Trp Leu Leu Val Gly Thr 
            20                  25                  30          


Lys Gln Gly His Leu Leu Leu Tyr Arg Ile Arg Lys Asp Val Val Pro 
        35                  40                  45              


Ala Asp Val Ala Ser Pro Glu Ser Gly Ser Cys Asn Arg Phe Glu Val 
    50                  55                  60                  


Thr Leu Glu Lys Ser Asn Lys Asn Phe Ser Lys Lys Ile Gln Gln Ile 
65                  70                  75                  80  


His Val Val Ser Gln Phe Lys Ile Leu Val Ser Leu Leu Glu Asn Asn 
                85                  90                  95      


Ile Tyr Val His Asp Leu Leu Thr Phe Gln Gln Ile Thr Thr Val Ser 
            100                 105                 110         


Lys Ala Lys Gly Ala Ser Leu Phe Thr Cys Asp Leu Gln His Thr Glu 
        115                 120                 125             


Thr Gly Glu Glu Val Leu Arg Met Cys Val Ala Val Lys Lys Lys Leu 
    130                 135                 140                 


Gln Leu Tyr Phe Trp Lys Asp Arg Glu Phe His Glu Leu Gln Gly Asp 
145                 150                 155                 160 


Phe Ser Val Pro Asp Val Pro Lys Ser Met Ala Trp Cys Glu Asn Ser 
                165                 170                 175     


Ile Cys Val Gly Phe Lys Arg Asp Tyr Tyr Leu Ile Arg Val Asp Gly 
            180                 185                 190         


Lys Gly Ser Ile Lys Glu Leu Phe Pro Thr Gly Lys Gln Leu Glu Pro 
        195                 200                 205             


Leu Val Ala Pro Leu Ala Asp Gly Lys Val Ala Val Gly Gln Asp Asp 
    210                 215                 220                 


Leu Thr Val Val Leu Asn Glu Glu Gly Ile Cys Thr Gln Lys Cys Ala 
225                 230                 235                 240 


Leu Asn Trp Thr Asp Ile Pro Val Ala Met Glu His Gln Pro Pro Tyr 
                245                 250                 255     


Ile Ile Ala Val Leu Pro Arg Tyr Val Glu Ile Arg Thr Phe Glu Pro 
            260                 265                 270         


Arg Leu Leu Val Gln Ser Ile Glu Leu Gln Arg Pro Arg Phe Ile Thr 
        275                 280                 285             


Ser Gly Gly Ser Asn Ile Ile Tyr Val Ala Ser Asn His Phe Val Trp 
    290                 295                 300                 


Arg Leu Ile Pro Val Pro Met Ala Thr Gln Ile Gln Gln Leu Leu Gln 
305                 310                 315                 320 


Asp Lys Gln Phe Glu Leu Ala Leu Gln Leu Ala Glu Met Lys Asp Asp 
                325                 330                 335     


Ser Asp Ser Glu Lys Gln Gln Gln Ile His His Ile Lys Asn Leu Tyr 
            340                 345                 350         


Ala Phe Asn Leu Phe Cys Gln Lys Arg Phe Asp Glu Ser Met Gln Val 
        355                 360                 365             


Phe Ala Lys Leu Gly Thr Asp Pro Thr His Val Met Gly Leu Tyr Pro 
    370                 375                 380                 


Asp Leu Leu Pro Thr Asp Tyr Arg Lys Gln Leu Gln Tyr Pro Asn Pro 
385                 390                 395                 400 


Leu Pro Val Leu Ser Gly Ala Glu Leu Glu Lys Ala His Leu Ala Leu 
                405                 410                 415     


Ile Asp Tyr Leu Thr Gln Lys Arg Ser Gln Leu Val Lys Lys Leu Asn 
            420                 425                 430         


Asp Ser Asp His Gln Ser Ser Thr Ser Pro Leu Met Glu Gly Thr Pro 
        435                 440                 445             


Thr Ile Lys Ser Lys Lys Lys Leu Leu Gln Ile Ile Asp Thr Thr Leu 
    450                 455                 460                 


Leu Lys Cys Tyr Leu His Thr Asn Val Ala Leu Val Ala Pro Leu Leu 
465                 470                 475                 480 


Arg Leu Glu Asn Asn His Cys His Ile Glu Glu Ser Glu His Val Leu 
                485                 490                 495     


Lys Lys Ala His Lys Tyr Ser Glu Leu Ile Ile Leu Tyr Glu Lys Lys 
            500                 505                 510         


Gly Leu His Glu Lys Ala Leu Gln Val Leu Val Asp Gln Ser Lys Lys 
        515                 520                 525             


Ala Asn Ser Pro Leu Lys Gly His Glu Arg Thr Val Gln Tyr Leu Gln 
    530                 535                 540                 


His Leu Gly Thr Glu Asn Leu His Leu Ile Phe Ser Tyr Ser Val Trp 
545                 550                 555                 560 


Val Leu Arg Asp Phe Pro Glu Asp Gly Leu Lys Ile Phe Thr Glu Asp 
                565                 570                 575     


Leu Pro Glu Val Glu Ser Leu Pro Arg Asp Arg Val Leu Gly Phe Leu 
            580                 585                 590         


Ile Glu Asn Phe Lys Gly Leu Ala Ile Pro Tyr Leu Glu His Ile Ile 
        595                 600                 605             


His Val Trp Glu Glu Thr Gly Ser Arg Phe His Asn Cys Leu Ile Gln 
    610                 615                 620                 


Leu Tyr Cys Glu Lys Val Gln Gly Leu Met Lys Glu Tyr Leu Leu Ser 
625                 630                 635                 640 


Phe Pro Ala Gly Lys Thr Pro Val Pro Ala Gly Glu Glu Glu Gly Glu 
                645                 650                 655     


Leu Gly Glu Tyr Arg Gln Lys Leu Leu Met Phe Leu Glu Ile Ser Ser 
            660                 665                 670         


Tyr Tyr Asp Pro Gly Arg Leu Ile Cys Asp Phe Pro Phe Asp Gly Leu 
        675                 680                 685             


Leu Glu Glu Arg Ala Leu Leu Leu Gly Arg Met Gly Lys His Glu Gln 
    690                 695                 700                 


Ala Leu Phe Ile Tyr Val His Ile Leu Lys Asp Thr Arg Met Ala Glu 
705                 710                 715                 720 


Glu Tyr Cys His Lys His Tyr Asp Arg Asn Lys Asp Gly Asn Lys Asp 
                725                 730                 735     


Val Tyr Leu Ser Leu Leu Arg Met Tyr Leu Ser Pro Pro Ser Ile His 
            740                 745                 750         


Cys Leu Gly Pro Ile Lys Leu Glu Leu Leu Glu Pro Lys Ala Asn Leu 
        755                 760                 765             


Gln Ala Ala Leu Gln Val Leu Glu Leu His His Ser Lys Leu Asp Thr 
    770                 775                 780                 


Thr Lys Ala Leu Asn Leu Leu Pro Ala Asn Thr Gln Ile Asn Asp Ile 
785                 790                 795                 800 


Arg Ile Phe Leu Glu Lys Val Leu Glu Glu Asn Ala Gln Lys Lys Arg 
                805                 810                 815     


Phe Asn Gln Val Leu Lys Asn Leu Leu His Ala Glu Phe Leu Arg Val 
            820                 825                 830         


Gln Glu Glu Arg Ile Leu His Gln Gln Val Lys Cys Ile Ile Thr Glu 
        835                 840                 845             


Glu Lys Val Cys Met Val Cys Lys Lys Lys Ile Gly Asn Ser Ala Phe 
    850                 855                 860                 


Ala Arg Tyr Pro Asn Gly Val Val Val His Tyr Phe Cys Ser Lys Glu 
865                 870                 875                 880 


Val Asn Pro Ala Asp Thr 
                885     


<210>  69
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Asp Leu Ser Ala Ala Ser His Arg Ile Pro Leu Ser Asp Gly Asn 
1               5                   10                  15      


Ser Ile Pro Ile Ile Gly Leu Gly Thr Tyr Ser Glu Pro Lys Ser Thr 
            20                  25                  30          


Pro Lys Gly Ala Cys Ala Thr Ser Val Lys Val Ala Ile Asp Thr Gly 
        35                  40                  45              


Tyr Arg His Ile Asp Gly Ala Tyr Ile Tyr Gln Asn Glu His Glu Val 
    50                  55                  60                  


Gly Glu Ala Ile Arg Glu Lys Ile Ala Glu Gly Lys Val Arg Arg Glu 
65                  70                  75                  80  


Asp Ile Phe Tyr Cys Gly Lys Leu Trp Ala Thr Asn His Val Pro Glu 
                85                  90                  95      


Met Val Arg Pro Thr Leu Glu Arg Thr Leu Arg Val Leu Gln Leu Asp 
            100                 105                 110         


Tyr Val Asp Leu Tyr Ile Ile Glu Val Pro Met Ala Phe Lys Pro Gly 
        115                 120                 125             


Asp Glu Ile Tyr Pro Arg Asp Glu Asn Gly Lys Trp Leu Tyr His Lys 
    130                 135                 140                 


Ser Asn Leu Cys Ala Thr Trp Glu Ala Met Glu Ala Cys Lys Asp Ala 
145                 150                 155                 160 


Gly Leu Val Lys Ser Leu Gly Val Ser Asn Phe Asn Arg Arg Gln Leu 
                165                 170                 175     


Glu Leu Ile Leu Asn Lys Pro Gly Leu Lys His Lys Pro Val Ser Asn 
            180                 185                 190         


Gln Val Glu Cys His Pro Tyr Phe Thr Gln Pro Lys Leu Leu Lys Phe 
        195                 200                 205             


Cys Gln Gln His Asp Ile Val Ile Thr Ala Tyr Ser Pro Leu Gly Thr 
    210                 215                 220                 


Ser Arg Asn Pro Ile Trp Val Asn Val Ser Ser Pro Pro Leu Leu Lys 
225                 230                 235                 240 


Asp Ala Leu Leu Asn Ser Leu Gly Lys Arg Tyr Asn Lys Thr Ala Ala 
                245                 250                 255     


Gln Ile Val Leu Arg Phe Asn Ile Gln Arg Gly Val Val Val Ile Pro 
            260                 265                 270         


Lys Ser Phe Asn Leu Glu Arg Ile Lys Glu Asn Phe Gln Ile Phe Asp 
        275                 280                 285             


Phe Ser Leu Thr Glu Glu Glu Met Lys Asp Ile Glu Ala Leu Asn Lys 
    290                 295                 300                 


Asn Val Arg Phe Val Glu Leu Leu Met Trp Arg Asp His Pro Glu Tyr 
305                 310                 315                 320 


Pro Phe His Asp Glu Tyr 
                325     


<210>  70
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val 
1               5                   10                  15      


Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala 
            20                  25                  30          


Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu 
        35                  40                  45              


Gly Gly Gly Gln Arg Arg Ile Asp Ala Gln His Lys Arg Gly Lys Leu 
    50                  55                  60                  


Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val 
65                  70                  75                  80  


Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala 
                85                  90                  95      


Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly 
            100                 105                 110         


Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln Asp Phe Thr Val 
        115                 120                 125             


Phe Gly Gly Ser Leu Ser Gly Ala His Ala Gln Lys Ile Cys Lys Ile 
    130                 135                 140                 


Met Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp 
145                 150                 155                 160 


Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr 
                165                 170                 175     


Ala Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln 
            180                 185                 190         


Ile Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro 
        195                 200                 205             


Ala Leu Thr Asp Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe 
    210                 215                 220                 


Ile Thr Gly Pro Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr 
225                 230                 235                 240 


Gln Glu Glu Leu Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val 
                245                 250                 255     


Ala His Arg Ala Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg 
            260                 265                 270         


Asp Phe Phe Asn Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Pro Val 
        275                 280                 285             


Arg Glu Cys His Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr 
    290                 295                 300                 


Ile Val Pro Leu Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile 
305                 310                 315                 320 


His Ser Val Val Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr 
                325                 330                 335     


Ala Lys Asn Ile Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val 
            340                 345                 350         


Gly Ile Val Gly Asn Gln Pro Lys Val Ala Ser Gly Cys Leu Asp Ile 
        355                 360                 365             


Asn Ser Ser Val Lys Gly Ala Arg Phe Val Arg Phe Cys Asp Ala Phe 
    370                 375                 380                 


Asn Ile Pro Leu Ile Thr Phe Val Asp Val Pro Gly Phe Leu Pro Gly 
385                 390                 395                 400 


Thr Ala Gln Glu Tyr Gly Gly Ile Ile Arg His Gly Ala Lys Leu Leu 
                405                 410                 415     


Tyr Ala Phe Ala Glu Ala Thr Val Pro Lys Val Thr Val Ile Thr Arg 
            420                 425                 430         


Lys Ala Tyr Gly Gly Ala Tyr Asp Val Met Ser Ser Lys His Leu Cys 
        435                 440                 445             


Gly Asp Thr Asn Tyr Ala Trp Pro Thr Ala Glu Ile Ala Val Met Gly 
    450                 455                 460                 


Ala Lys Gly Ala Val Glu Ile Ile Phe Lys Gly His Glu Asn Val Glu 
465                 470                 475                 480 


Ala Ala Gln Ala Glu Tyr Ile Glu Lys Phe Ala Asn Pro Phe Pro Ala 
                485                 490                 495     


Ala Val Arg Gly Phe Val Asp Asp Ile Ile Gln Pro Ser Ser Thr Arg 
            500                 505                 510         


Ala Arg Ile Cys Cys Asp Leu Asp Val Leu Ala Ser Lys Lys Val Gln 
        515                 520                 525             


Arg Pro Trp Arg Lys His Ala Asn Ile Pro Leu 
    530                 535                 


<210>  71
<211>  796
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Ser Ala Ala Gln Val Ser Ser Ser Arg Arg Gln Ser Cys Tyr Leu 
1               5                   10                  15      


Cys Asp Leu Pro Arg Met Pro Trp Ala Met Ile Trp Asp Phe Ser Glu 
            20                  25                  30          


Pro Val Cys Arg Gly Cys Val Asn Tyr Glu Gly Ala Asp Arg Ile Glu 
        35                  40                  45              


Phe Val Ile Glu Thr Ala Arg Gln Leu Lys Arg Ala His Gly Cys Phe 
    50                  55                  60                  


Gln Asp Gly Arg Ser Pro Gly Pro Pro Pro Pro Val Gly Val Lys Thr 
65                  70                  75                  80  


Val Ala Leu Ser Ala Lys Glu Ala Ala Ala Ala Ala Ala Ala Ala Ala 
                85                  90                  95      


Ala Ala Ala Ala Ala Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            100                 105                 110         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Leu 
        115                 120                 125             


Asn His Val Asp Gly Ser Ser Lys Pro Ala Val Leu Ala Ala Pro Ser 
    130                 135                 140                 


Gly Leu Glu Arg Tyr Gly Leu Ser Ala Ala Ala Ala Ala Ala Ala Ala 
145                 150                 155                 160 


Ala Ala Ala Ala Val Glu Gln Arg Ser Arg Phe Glu Tyr Pro Pro Pro 
                165                 170                 175     


Pro Val Ser Leu Gly Ser Ser Ser His Thr Ala Arg Leu Pro Asn Gly 
            180                 185                 190         


Leu Gly Gly Pro Asn Gly Phe Pro Lys Pro Thr Pro Glu Glu Gly Pro 
        195                 200                 205             


Pro Glu Leu Asn Arg Gln Ser Pro Asn Ser Ser Ser Ala Ala Ala Ser 
    210                 215                 220                 


Val Ala Ser Arg Arg Gly Thr His Gly Gly Leu Val Thr Gly Leu Pro 
225                 230                 235                 240 


Asn Pro Gly Gly Gly Gly Gly Pro Gln Leu Thr Val Pro Pro Asn Leu 
                245                 250                 255     


Leu Pro Gln Thr Leu Leu Asn Gly Pro Ala Ser Ala Ala Val Leu Pro 
            260                 265                 270         


Pro Pro Pro Pro His Ala Leu Gly Ser Arg Gly Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Pro Gly Ala Pro Gly Gly Pro Ala Cys Leu Gly Gly Thr Pro Gly 
    290                 295                 300                 


Val Ser Ala Thr Ser Ser Ser Ala Ser Ser Ser Thr Ser Ser Ser Val 
305                 310                 315                 320 


Ala Glu Val Gly Val Gly Ala Gly Gly Lys Arg Pro Gly Ser Val Ser 
                325                 330                 335     


Ser Thr Asp Gln Glu Arg Glu Leu Lys Glu Lys Gln Arg Asn Ala Glu 
            340                 345                 350         


Ala Leu Ala Glu Leu Ser Glu Ser Leu Arg Asn Arg Ala Glu Glu Trp 
        355                 360                 365             


Ala Ser Lys Pro Lys Met Val Arg Asp Thr Leu Leu Thr Leu Ala Gly 
    370                 375                 380                 


Cys Thr Pro Tyr Glu Val Arg Phe Lys Lys Asp His Ser Leu Leu Gly 
385                 390                 395                 400 


Arg Val Phe Ala Phe Asp Ala Val Ser Lys Pro Gly Met Asp Tyr Glu 
                405                 410                 415     


Leu Lys Leu Phe Ile Glu Tyr Pro Thr Gly Ser Gly Asn Val Tyr Ser 
            420                 425                 430         


Ser Ala Ser Gly Val Ala Lys Gln Met Tyr Gln Asp Cys Met Lys Asp 
        435                 440                 445             


Phe Gly Arg Gly Leu Ser Ser Gly Phe Lys Tyr Leu Glu Tyr Glu Lys 
    450                 455                 460                 


Lys His Gly Ser Gly Asp Trp Arg Leu Leu Gly Asp Leu Leu Pro Glu 
465                 470                 475                 480 


Ala Val Arg Phe Phe Lys Glu Gly Val Pro Gly Ala Asp Met Leu Pro 
                485                 490                 495     


Gln Pro Tyr Leu Asp Ala Ser Cys Pro Met Leu Pro Thr Ala Leu Val 
            500                 505                 510         


Ser Leu Ser Arg Ala Pro Ser Ala Pro Pro Gly Thr Gly Ala Leu Pro 
        515                 520                 525             


Pro Ala Ala Pro Ser Gly Arg Gly Ala Ala Ala Ser Leu Arg Lys Arg 
    530                 535                 540                 


Lys Ala Ser Pro Glu Pro Pro Asp Ser Ala Glu Gly Ala Leu Lys Leu 
545                 550                 555                 560 


Gly Glu Glu Gln Gln Arg Gln Gln Trp Met Ala Asn Gln Ser Glu Ala 
                565                 570                 575     


Leu Lys Leu Thr Met Ser Ala Gly Gly Phe Ala Ala Pro Gly His Ala 
            580                 585                 590         


Ala Gly Gly Pro Pro Pro Pro Pro Pro Pro Leu Gly Pro His Ser Asn 
        595                 600                 605             


Arg Thr Thr Pro Pro Glu Ser Ala Pro Gln Asn Gly Pro Ser Pro Met 
    610                 615                 620                 


Ala Ala Leu Met Ser Val Ala Asp Thr Leu Gly Thr Ala His Ser Pro 
625                 630                 635                 640 


Lys Asp Gly Ser Ser Val His Ser Thr Thr Ala Ser Ala Arg Arg Asn 
                645                 650                 655     


Ser Ser Ser Pro Val Ser Pro Ala Ser Val Pro Gly Gln Arg Arg Leu 
            660                 665                 670         


Ala Ser Arg Asn Gly Asp Leu Asn Leu Gln Val Ala Pro Pro Pro Pro 
        675                 680                 685             


Ser Ala His Pro Gly Met Asp Gln Val His Pro Gln Asn Ile Pro Asp 
    690                 695                 700                 


Ser Pro Met Ala Asn Ser Gly Pro Leu Cys Cys Thr Ile Cys His Glu 
705                 710                 715                 720 


Arg Leu Glu Asp Thr His Phe Val Gln Cys Pro Ser Val Pro Ser His 
                725                 730                 735     


Lys Phe Cys Phe Pro Cys Ser Arg Glu Ser Ile Lys Ala Gln Gly Ala 
            740                 745                 750         


Thr Gly Glu Val Tyr Cys Pro Ser Gly Glu Lys Cys Pro Leu Val Gly 
        755                 760                 765             


Ser Asn Val Pro Trp Ala Phe Met Gln Gly Glu Ile Ala Thr Ile Leu 
    770                 775                 780                 


Ala Gly Asp Val Lys Val Lys Lys Glu Arg Asp Pro 
785                 790                 795     


<210>  72
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Arg Ala Pro Gly Met Arg Ser Arg Pro Ala Gly Pro Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Phe Leu Gly Ala Ala Glu Ser Val Arg Arg Ala Gln 
            20                  25                  30          


Pro Pro Arg Arg Tyr Thr Pro Asp Trp Pro Ser Leu Asp Ser Arg Pro 
        35                  40                  45              


Leu Pro Ala Trp Phe Asp Glu Ala Lys Phe Gly Val Phe Ile His Trp 
    50                  55                  60                  


Gly Val Phe Ser Val Pro Ala Trp Gly Ser Glu Trp Phe Trp Trp His 
65                  70                  75                  80  


Trp Gln Gly Glu Gly Arg Pro Gln Tyr Gln Arg Phe Met Arg Asp Asn 
                85                  90                  95      


Tyr Pro Pro Gly Phe Ser Tyr Ala Asp Phe Gly Pro Gln Phe Thr Ala 
            100                 105                 110         


Arg Phe Phe His Pro Glu Glu Trp Ala Asp Leu Phe Gln Ala Ala Gly 
        115                 120                 125             


Ala Lys Tyr Val Val Leu Thr Thr Lys His His Glu Gly Phe Thr Asn 
    130                 135                 140                 


Trp Pro Ser Pro Val Ser Trp Asn Trp Asn Ser Lys Asp Val Gly Pro 
145                 150                 155                 160 


His Arg Asp Leu Val Gly Glu Leu Gly Thr Ala Leu Arg Lys Arg Asn 
                165                 170                 175     


Ile Arg Tyr Gly Leu Tyr His Ser Leu Leu Glu Trp Phe His Pro Leu 
            180                 185                 190         


Tyr Leu Leu Asp Lys Lys Asn Gly Phe Lys Thr Gln His Phe Val Ser 
        195                 200                 205             


Ala Lys Thr Met Pro Glu Leu Tyr Asp Leu Val Asn Ser Tyr Lys Pro 
    210                 215                 220                 


Asp Leu Ile Trp Ser Asp Gly Glu Trp Glu Cys Pro Asp Thr Tyr Trp 
225                 230                 235                 240 


Asn Ser Thr Asn Phe Leu Ser Trp Leu Tyr Asn Asp Ser Pro Val Lys 
                245                 250                 255     


Asp Glu Val Val Val Asn Asp Arg Trp Gly Gln Asn Cys Ser Cys His 
            260                 265                 270         


His Gly Gly Tyr Tyr Asn Cys Glu Asp Lys Phe Lys Pro Gln Ser Leu 
        275                 280                 285             


Pro Asp His Lys Trp Glu Met Cys Thr Ser Ile Asp Lys Phe Ser Trp 
    290                 295                 300                 


Gly Tyr Arg Arg Asp Met Ala Leu Ser Asp Val Thr Glu Glu Ser Glu 
305                 310                 315                 320 


Ile Ile Ser Glu Leu Val Gln Thr Val Ser Leu Gly Gly Asn Tyr Leu 
                325                 330                 335     


Leu Asn Ile Gly Pro Thr Lys Asp Gly Leu Ile Val Pro Ile Phe Gln 
            340                 345                 350         


Glu Arg Leu Leu Ala Val Gly Lys Trp Leu Ser Ile Asn Gly Glu Ala 
        355                 360                 365             


Ile Tyr Ala Ser Lys Pro Trp Arg Val Gln Trp Glu Lys Asn Thr Thr 
    370                 375                 380                 


Ser Val Trp Tyr Thr Ser Lys Gly Ser Ala Val Tyr Ala Ile Phe Leu 
385                 390                 395                 400 


His Trp Pro Glu Asn Gly Val Leu Asn Leu Glu Ser Pro Ile Thr Thr 
                405                 410                 415     


Ser Thr Thr Lys Ile Thr Met Leu Gly Ile Gln Gly Asp Leu Lys Trp 
            420                 425                 430         


Ser Thr Asp Pro Asp Lys Gly Leu Phe Ile Ser Leu Pro Gln Leu Pro 
        435                 440                 445             


Pro Ser Ala Val Pro Ala Glu Phe Ala Trp Thr Ile Lys Leu Thr Gly 
    450                 455                 460                 


Val Lys 
465     


<210>  73
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Asp Ser Lys Tyr Gln Cys Val Lys Leu Asn Asp Gly His Phe Met 
1               5                   10                  15      


Pro Val Leu Gly Phe Gly Thr Tyr Ala Pro Ala Glu Val Pro Lys Ser 
            20                  25                  30          


Lys Ala Leu Glu Ala Val Lys Leu Ala Ile Glu Ala Gly Phe His His 
        35                  40                  45              


Ile Asp Ser Ala His Val Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala 
    50                  55                  60                  


Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe 
65                  70                  75                  80  


Tyr Thr Ser Lys Leu Trp Ser Asn Ser His Arg Pro Glu Leu Val Arg 
                85                  90                  95      


Pro Ala Leu Glu Arg Ser Leu Lys Asn Leu Gln Leu Asp Tyr Val Asp 
            100                 105                 110         


Leu Tyr Leu Ile His Phe Pro Val Ser Val Lys Pro Gly Glu Glu Val 
        115                 120                 125             


Ile Pro Lys Asp Glu Asn Gly Lys Ile Leu Phe Asp Thr Val Asp Leu 
    130                 135                 140                 


Cys Ala Thr Trp Glu Ala Met Glu Lys Cys Lys Asp Ala Gly Leu Ala 
145                 150                 155                 160 


Lys Ser Ile Gly Val Ser Asn Phe Asn His Arg Leu Leu Glu Met Ile 
                165                 170                 175     


Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu 
            180                 185                 190         


Cys His Pro Tyr Phe Asn Gln Arg Lys Leu Leu Asp Phe Cys Lys Ser 
        195                 200                 205             


Lys Asp Ile Val Leu Val Ala Tyr Ser Ala Leu Gly Ser His Arg Glu 
    210                 215                 220                 


Glu Pro Trp Val Asp Pro Asn Ser Pro Val Leu Leu Glu Asp Pro Val 
225                 230                 235                 240 


Leu Cys Ala Leu Ala Lys Lys His Lys Arg Thr Pro Ala Leu Ile Ala 
                245                 250                 255     


Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Val Leu Ala Lys Ser Tyr 
            260                 265                 270         


Asn Glu Gln Arg Ile Arg Gln Asn Val Gln Val Phe Glu Phe Gln Leu 
        275                 280                 285             


Thr Ser Glu Glu Met Lys Ala Ile Asp Gly Leu Asn Arg Asn Val Arg 
    290                 295                 300                 


Tyr Leu Thr Leu Asp Ile Phe Ala Gly Pro Pro Asn Tyr Pro Phe Ser 
305                 310                 315                 320 


Asp Glu Tyr 
            


<210>  74
<211>  547
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ala Met Gly Leu Phe Arg Val Cys Leu Val Val Val Thr Ala Ile 
1               5                   10                  15      


Ile Asn His Pro Leu Leu Phe Pro Arg Glu Asn Ala Thr Val Pro Glu 
            20                  25                  30          


Asn Glu Glu Glu Ile Ile Arg Lys Met Gln Ala His Gln Glu Lys Leu 
        35                  40                  45              


Gln Leu Glu Gln Leu Arg Leu Glu Glu Glu Val Ala Arg Leu Ala Ala 
    50                  55                  60                  


Glu Lys Glu Ala Leu Glu Gln Val Ala Glu Glu Gly Arg Gln Gln Asn 
65                  70                  75                  80  


Glu Thr Arg Val Ala Trp Asp Leu Trp Ser Thr Leu Cys Met Ile Leu 
                85                  90                  95      


Phe Leu Met Ile Glu Val Trp Arg Gln Asp His Gln Glu Gly Pro Ser 
            100                 105                 110         


Pro Glu Cys Leu Gly Gly Glu Glu Asp Glu Leu Pro Gly Leu Gly Gly 
        115                 120                 125             


Ala Pro Leu Gln Gly Leu Thr Leu Pro Asn Lys Ala Thr Leu Gly His 
    130                 135                 140                 


Phe Tyr Glu Arg Cys Ile Arg Gly Ala Thr Ala Asp Ala Ala Arg Thr 
145                 150                 155                 160 


Arg Glu Phe Leu Glu Gly Phe Val Asp Asp Leu Leu Glu Ala Leu Arg 
                165                 170                 175     


Ser Leu Cys Asn Arg Asp Thr Asp Met Glu Val Glu Asp Phe Ile Gly 
            180                 185                 190         


Val Asp Ser Met Tyr Glu Asn Trp Gln Val Asp Arg Pro Leu Leu Cys 
        195                 200                 205             


His Leu Phe Val Pro Phe Thr Pro Pro Glu Pro Tyr Arg Phe His Pro 
    210                 215                 220                 


Glu Leu Trp Cys Ser Gly Arg Ser Val Pro Leu Asp Arg Gln Gly Tyr 
225                 230                 235                 240 


Gly Gln Ile Lys Val Val Arg Ala Asp Gly Asp Thr Leu Ser Cys Ile 
                245                 250                 255     


Cys Gly Lys Thr Lys Leu Gly Glu Asp Met Leu Cys Leu Leu His Gly 
            260                 265                 270         


Arg Asn Ser Met Ala Pro Pro Cys Gly Asp Met Glu Asn Leu Leu Cys 
        275                 280                 285             


Ala Thr Asp Ser Leu Tyr Leu Asp Thr Met Gln Val Met Lys Trp Phe 
    290                 295                 300                 


Gln Thr Ala Leu Thr Arg Ala Trp Lys Gly Ile Ala His Lys Tyr Glu 
305                 310                 315                 320 


Phe Asp Leu Ala Phe Gly Gln Leu Asp Ser Pro Gly Ser Leu Lys Ile 
                325                 330                 335     


Lys Phe Arg Ser Gly Lys Phe Met Pro Phe Asn Leu Ile Pro Val Ile 
            340                 345                 350         


Gln Cys Asp Asp Ser Asp Leu Tyr Phe Val Ser His Leu Pro Arg Glu 
        355                 360                 365             


Pro Ser Glu Gly Thr Pro Ala Ser Ser Thr Asp Trp Leu Leu Ser Phe 
    370                 375                 380                 


Ala Val Tyr Glu Arg His Phe Leu Arg Thr Thr Leu Lys Ala Leu Pro 
385                 390                 395                 400 


Glu Gly Ala Cys His Leu Ser Cys Leu Gln Ile Ala Ser Phe Leu Leu 
                405                 410                 415     


Ser Lys Gln Ser Arg Leu Thr Gly Pro Ser Gly Leu Ser Ser Tyr His 
            420                 425                 430         


Leu Lys Thr Ala Leu Leu His Leu Leu Leu Leu Arg Gln Ala Ala Asp 
        435                 440                 445             


Trp Lys Ala Gly Gln Leu Asp Ala Arg Leu His Glu Leu Leu Cys Phe 
    450                 455                 460                 


Leu Glu Lys Ser Leu Leu Gln Lys Lys Leu His His Phe Phe Ile Gly 
465                 470                 475                 480 


Asn Arg Lys Val Pro Glu Ala Met Gly Leu Pro Glu Ala Val Leu Arg 
                485                 490                 495     


Ala Glu Pro Leu Asn Leu Phe Arg Pro Phe Val Leu Gln Arg Ser Leu 
            500                 505                 510         


Tyr Arg Lys Thr Leu Asp Ser Phe Tyr Glu Met Leu Lys Asn Ala Pro 
        515                 520                 525             


Ala Leu Ile Ser Glu Tyr Ser Leu His Val Pro Ser Asp Gln Pro Thr 
    530                 535                 540                 


Pro Lys Ser 
545         


<210>  75
<211>  1361
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Gly Ala Ala Gly Arg Gln Asp Phe Leu Phe Lys Ala Met Leu Thr 
1               5                   10                  15      


Ile Ser Trp Leu Thr Leu Thr Cys Phe Pro Gly Ala Thr Ser Thr Val 
            20                  25                  30          


Ala Ala Gly Cys Pro Asp Gln Ser Pro Glu Leu Gln Pro Trp Asn Pro 
        35                  40                  45              


Gly His Asp Gln Asp His His Val His Ile Gly Gln Gly Lys Thr Leu 
    50                  55                  60                  


Leu Leu Thr Ser Ser Ala Thr Val Tyr Ser Ile His Ile Ser Glu Gly 
65                  70                  75                  80  


Gly Lys Leu Val Ile Lys Asp His Asp Glu Pro Ile Val Leu Arg Thr 
                85                  90                  95      


Arg His Ile Leu Ile Asp Asn Gly Gly Glu Leu His Ala Gly Ser Ala 
            100                 105                 110         


Leu Cys Pro Phe Gln Gly Asn Phe Thr Ile Ile Leu Tyr Gly Arg Ala 
        115                 120                 125             


Asp Glu Gly Ile Gln Pro Asp Pro Tyr Tyr Gly Leu Lys Tyr Ile Gly 
    130                 135                 140                 


Val Gly Lys Gly Gly Ala Leu Glu Leu His Gly Gln Lys Lys Leu Ser 
145                 150                 155                 160 


Trp Thr Phe Leu Asn Lys Thr Leu His Pro Gly Gly Met Ala Glu Gly 
                165                 170                 175     


Gly Tyr Phe Phe Glu Arg Ser Trp Gly His Arg Gly Val Ile Val His 
            180                 185                 190         


Val Ile Asp Pro Lys Ser Gly Thr Val Ile His Ser Asp Arg Phe Asp 
        195                 200                 205             


Thr Tyr Arg Ser Lys Lys Glu Ser Glu Arg Leu Val Gln Tyr Leu Asn 
    210                 215                 220                 


Ala Val Pro Asp Gly Arg Ile Leu Ser Val Ala Val Asn Asp Glu Gly 
225                 230                 235                 240 


Ser Arg Asn Leu Asp Asp Met Ala Arg Lys Ala Met Thr Lys Leu Gly 
                245                 250                 255     


Ser Lys His Phe Leu His Leu Gly Phe Arg His Pro Trp Ser Phe Leu 
            260                 265                 270         


Thr Val Lys Gly Asn Pro Ser Ser Ser Val Glu Asp His Ile Glu Tyr 
        275                 280                 285             


His Gly His Arg Gly Ser Ala Ala Ala Arg Val Phe Lys Leu Phe Gln 
    290                 295                 300                 


Thr Glu His Gly Glu Tyr Phe Asn Val Ser Leu Ser Ser Glu Trp Val 
305                 310                 315                 320 


Gln Asp Val Glu Trp Thr Glu Trp Phe Asp His Asp Lys Val Ser Gln 
                325                 330                 335     


Thr Lys Gly Gly Glu Lys Ile Ser Asp Leu Trp Lys Ala His Pro Gly 
            340                 345                 350         


Lys Ile Cys Asn Arg Pro Ile Asp Ile Gln Ala Thr Thr Met Asp Gly 
        355                 360                 365             


Val Asn Leu Ser Thr Glu Val Val Tyr Lys Lys Gly Gln Asp Tyr Arg 
    370                 375                 380                 


Phe Ala Cys Tyr Asp Arg Gly Arg Ala Cys Arg Ser Tyr Arg Val Arg 
385                 390                 395                 400 


Phe Leu Cys Gly Lys Pro Val Arg Pro Lys Leu Thr Val Thr Ile Asp 
                405                 410                 415     


Thr Asn Val Asn Ser Thr Ile Leu Asn Leu Glu Asp Asn Val Gln Ser 
            420                 425                 430         


Trp Lys Pro Gly Asp Thr Leu Val Ile Ala Ser Thr Asp Tyr Ser Met 
        435                 440                 445             


Tyr Gln Ala Glu Glu Phe Gln Val Leu Pro Cys Arg Ser Cys Ala Pro 
    450                 455                 460                 


Asn Gln Val Lys Val Ala Gly Lys Pro Met Tyr Leu His Ile Gly Glu 
465                 470                 475                 480 


Glu Ile Asp Gly Val Asp Met Arg Ala Glu Val Gly Leu Leu Ser Arg 
                485                 490                 495     


Asn Ile Ile Val Met Gly Glu Met Glu Asp Lys Cys Tyr Pro Tyr Arg 
            500                 505                 510         


Asn His Ile Cys Asn Phe Phe Asp Phe Asp Thr Phe Gly Gly His Ile 
        515                 520                 525             


Lys Phe Ala Leu Gly Phe Lys Ala Ala His Leu Glu Gly Thr Glu Leu 
    530                 535                 540                 


Lys His Met Gly Gln Gln Leu Val Gly Gln Tyr Pro Ile His Phe His 
545                 550                 555                 560 


Leu Ala Gly Asp Val Asp Glu Arg Gly Gly Tyr Asp Pro Pro Thr Tyr 
                565                 570                 575     


Ile Arg Asp Leu Ser Ile His His Thr Phe Ser Arg Cys Val Thr Val 
            580                 585                 590         


His Gly Ser Asn Gly Leu Leu Ile Lys Asp Val Val Gly Tyr Asn Ser 
        595                 600                 605             


Leu Gly His Cys Phe Phe Thr Glu Asp Gly Pro Glu Glu Arg Asn Thr 
    610                 615                 620                 


Phe Asp His Cys Leu Gly Leu Leu Val Lys Ser Gly Thr Leu Leu Pro 
625                 630                 635                 640 


Ser Asp Arg Asp Ser Lys Met Cys Lys Met Ile Thr Glu Asp Ser Tyr 
                645                 650                 655     


Pro Gly Tyr Ile Pro Lys Pro Arg Gln Asp Cys Asn Ala Val Ser Thr 
            660                 665                 670         


Phe Trp Met Ala Asn Pro Asn Asn Asn Leu Ile Asn Cys Ala Ala Ala 
        675                 680                 685             


Gly Ser Glu Glu Thr Gly Phe Trp Phe Ile Phe His His Val Pro Thr 
    690                 695                 700                 


Gly Pro Ser Val Gly Met Tyr Ser Pro Gly Tyr Ser Glu His Ile Pro 
705                 710                 715                 720 


Leu Gly Lys Phe Tyr Asn Asn Arg Ala His Ser Asn Tyr Arg Ala Gly 
                725                 730                 735     


Met Ile Ile Asp Asn Gly Val Lys Thr Thr Glu Ala Ser Ala Lys Asp 
            740                 745                 750         


Lys Arg Pro Phe Leu Ser Ile Ile Ser Ala Arg Tyr Ser Pro His Gln 
        755                 760                 765             


Asp Ala Asp Pro Leu Lys Pro Arg Glu Pro Ala Ile Ile Arg His Phe 
    770                 775                 780                 


Ile Ala Tyr Lys Asn Gln Asp His Gly Ala Trp Leu Arg Gly Gly Asp 
785                 790                 795                 800 


Val Trp Leu Asp Ser Cys Arg Phe Ala Asp Asn Gly Ile Gly Leu Thr 
                805                 810                 815     


Leu Ala Ser Gly Gly Thr Phe Pro Tyr Asp Asp Gly Ser Lys Gln Glu 
            820                 825                 830         


Ile Lys Asn Ser Leu Phe Val Gly Glu Ser Gly Asn Val Gly Thr Glu 
        835                 840                 845             


Met Met Asp Asn Arg Ile Trp Gly Pro Gly Gly Leu Asp His Ser Gly 
    850                 855                 860                 


Arg Thr Leu Pro Ile Gly Gln Asn Phe Pro Ile Arg Gly Ile Gln Leu 
865                 870                 875                 880 


Tyr Asp Gly Pro Ile Asn Ile Gln Asn Cys Thr Phe Arg Lys Phe Val 
                885                 890                 895     


Ala Leu Glu Gly Arg His Thr Ser Ala Leu Ala Phe Arg Leu Asn Asn 
            900                 905                 910         


Ala Trp Gln Ser Cys Pro His Asn Asn Val Thr Gly Ile Ala Phe Glu 
        915                 920                 925             


Asp Val Pro Ile Thr Ser Arg Val Phe Phe Gly Glu Pro Gly Pro Trp 
    930                 935                 940                 


Phe Asn Gln Leu Asp Met Asp Gly Asp Lys Thr Ser Val Phe His Asp 
945                 950                 955                 960 


Val Asp Gly Ser Val Ser Glu Tyr Pro Gly Ser Tyr Leu Thr Lys Asn 
                965                 970                 975     


Asp Asn Trp Leu Val Arg His Pro Asp Cys Ile Asn Val Pro Asp Trp 
            980                 985                 990         


Arg Gly Ala Ile Cys Ser Gly Cys  Tyr Ala Gln Met Tyr  Ile Gln Ala 
        995                 1000                 1005             


Tyr Lys  Thr Ser Asn Leu Arg  Met Lys Ile Ile Lys  Asn Asp Phe 
    1010                 1015                 1020             


Pro Ser  His Pro Leu Tyr Leu  Glu Gly Ala Leu Thr  Arg Ser Thr 
    1025                 1030                 1035             


His Tyr  Gln Gln Tyr Gln Pro  Val Val Thr Leu Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Ile  His Trp Asp Gln Thr  Ala Pro Ala Glu Leu  Ala Ile Trp 
    1055                 1060                 1065             


Leu Ile  Asn Phe Asn Lys Gly  Asp Trp Ile Arg Val  Gly Leu Cys 
    1070                 1075                 1080             


Tyr Pro  Arg Gly Thr Thr Phe  Ser Ile Leu Ser Asp  Val His Asn 
    1085                 1090                 1095             


Arg Leu  Leu Lys Gln Thr Ser  Lys Thr Gly Val Phe  Val Arg Thr 
    1100                 1105                 1110             


Leu Gln  Met Asp Lys Val Glu  Gln Ser Tyr Pro Gly  Arg Ser His 
    1115                 1120                 1125             


Tyr Tyr  Trp Asp Glu Asp Ser  Gly Leu Leu Phe Leu  Lys Leu Lys 
    1130                 1135                 1140             


Ala Gln  Asn Glu Arg Glu Lys  Phe Ala Phe Cys Ser  Met Lys Gly 
    1145                 1150                 1155             


Cys Glu  Arg Ile Lys Ile Lys  Ala Leu Ile Pro Lys  Asn Ala Gly 
    1160                 1165                 1170             


Val Ser  Asp Cys Thr Ala Thr  Ala Tyr Pro Lys Phe  Thr Glu Arg 
    1175                 1180                 1185             


Ala Val  Val Asp Val Pro Met  Pro Lys Lys Leu Phe  Gly Ser Gln 
    1190                 1195                 1200             


Leu Lys  Thr Lys Asp His Phe  Leu Glu Val Lys Met  Glu Ser Ser 
    1205                 1210                 1215             


Lys Gln  His Phe Phe His Leu  Trp Asn Asp Phe Ala  Tyr Ile Glu 
    1220                 1225                 1230             


Val Asp  Gly Lys Lys Tyr Pro  Ser Ser Glu Asp Gly  Ile Gln Val 
    1235                 1240                 1245             


Val Val  Ile Asp Gly Asn Gln  Gly Arg Val Val Ser  His Thr Ser 
    1250                 1255                 1260             


Phe Arg  Asn Ser Ile Leu Gln  Gly Ile Pro Trp Gln  Leu Phe Asn 
    1265                 1270                 1275             


Tyr Val  Ala Thr Ile Pro Asp  Asn Ser Ile Val Leu  Met Ala Ser 
    1280                 1285                 1290             


Lys Gly  Arg Tyr Val Ser Arg  Gly Pro Trp Thr Arg  Val Leu Glu 
    1295                 1300                 1305             


Lys Leu  Gly Ala Asp Arg Gly  Leu Lys Leu Lys Glu  Gln Met Ala 
    1310                 1315                 1320             


Phe Val  Gly Phe Lys Gly Ser  Phe Arg Pro Ile Trp  Val Thr Leu 
    1325                 1330                 1335             


Asp Thr  Glu Asp His Lys Ala  Lys Ile Phe Gln Val  Val Pro Ile 
    1340                 1345                 1350             


Pro Val  Val Lys Lys Lys Lys  Leu 
    1355                 1360     


<210>  76
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ala Thr Lys Cys Gly Asn Cys Gly Pro Gly Tyr Ser Thr Pro Leu 
1               5                   10                  15      


Glu Ala Met Lys Gly Pro Arg Glu Glu Ile Val Tyr Leu Pro Cys Ile 
            20                  25                  30          


Tyr Arg Asn Thr Gly Thr Glu Ala Pro Asp Tyr Leu Ala Thr Val Asp 
        35                  40                  45              


Val Asp Pro Lys Ser Pro Gln Tyr Cys Gln Val Ile His Arg Leu Pro 
    50                  55                  60                  


Met Pro Asn Leu Lys Asp Glu Leu His His Ser Gly Trp Asn Thr Cys 
65                  70                  75                  80  


Ser Ser Cys Phe Gly Asp Ser Thr Lys Ser Arg Thr Lys Leu Val Leu 
                85                  90                  95      


Pro Ser Leu Ile Ser Ser Arg Ile Tyr Val Val Asp Val Gly Ser Glu 
            100                 105                 110         


Pro Arg Ala Pro Lys Leu His Lys Val Ile Glu Pro Lys Asp Ile His 
        115                 120                 125             


Ala Lys Cys Glu Leu Ala Phe Leu His Thr Ser His Cys Leu Ala Ser 
    130                 135                 140                 


Gly Glu Val Met Ile Ser Ser Leu Gly Asp Val Lys Gly Asn Gly Lys 
145                 150                 155                 160 


Gly Gly Phe Val Leu Leu Asp Gly Glu Thr Phe Glu Val Lys Gly Thr 
                165                 170                 175     


Trp Glu Arg Pro Gly Gly Ala Ala Pro Leu Gly Tyr Asp Phe Trp Tyr 
            180                 185                 190         


Gln Pro Arg His Asn Val Met Ile Ser Thr Glu Trp Ala Ala Pro Asn 
        195                 200                 205             


Val Leu Arg Asp Gly Phe Asn Pro Ala Asp Val Glu Ala Gly Leu Tyr 
    210                 215                 220                 


Gly Ser His Leu Tyr Val Trp Asp Trp Gln Arg His Glu Ile Val Gln 
225                 230                 235                 240 


Thr Leu Ser Leu Lys Asp Gly Leu Ile Pro Leu Glu Ile Arg Phe Leu 
                245                 250                 255     


His Asn Pro Asp Ala Ala Gln Gly Phe Val Gly Cys Ala Leu Ser Ser 
            260                 265                 270         


Thr Ile Gln Arg Phe Tyr Lys Asn Glu Gly Gly Thr Trp Ser Val Glu 
        275                 280                 285             


Lys Val Ile Gln Val Pro Pro Lys Lys Val Lys Gly Trp Leu Leu Pro 
    290                 295                 300                 


Glu Met Pro Gly Leu Ile Thr Asp Ile Leu Leu Ser Leu Asp Asp Arg 
305                 310                 315                 320 


Phe Leu Tyr Phe Ser Asn Trp Leu His Gly Asp Leu Arg Gln Tyr Asp 
                325                 330                 335     


Ile Ser Asp Pro Gln Arg Pro Arg Leu Thr Gly Gln Leu Phe Leu Gly 
            340                 345                 350         


Gly Ser Ile Val Lys Gly Gly Pro Val Gln Val Leu Glu Asp Glu Glu 
        355                 360                 365             


Leu Lys Ser Gln Pro Glu Pro Leu Val Val Lys Gly Lys Arg Val Ala 
    370                 375                 380                 


Gly Gly Pro Gln Met Ile Gln Leu Ser Leu Asp Gly Lys Arg Leu Tyr 
385                 390                 395                 400 


Ile Thr Thr Ser Leu Tyr Ser Ala Trp Asp Lys Gln Phe Tyr Pro Asp 
                405                 410                 415     


Leu Ile Arg Glu Gly Ser Val Met Leu Gln Val Asp Val Asp Thr Val 
            420                 425                 430         


Lys Gly Gly Leu Lys Leu Asn Pro Asn Phe Leu Val Asp Phe Gly Lys 
        435                 440                 445             


Glu Pro Leu Gly Pro Ala Leu Ala His Glu Leu Arg Tyr Pro Gly Gly 
    450                 455                 460                 


Asp Cys Ser Ser Asp Ile Trp Ile 
465                 470         


<210>  77
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Lys Pro Lys Leu Met Tyr Gln Glu Leu Lys Val Pro Ala Glu Glu 
1               5                   10                  15      


Pro Ala Asn Glu Leu Pro Met Asn Glu Ile Glu Ala Trp Lys Ala Ala 
            20                  25                  30          


Glu Lys Lys Ala Arg Trp Val Leu Leu Val Leu Ile Leu Ala Val Val 
        35                  40                  45              


Gly Phe Gly Ala Leu Met Thr Gln Leu Phe Leu Trp Glu Tyr Gly Asp 
    50                  55                  60                  


Leu His Leu Phe Gly Pro Asn Gln Arg Pro Ala Pro Cys Tyr Asp Pro 
65                  70                  75                  80  


Cys Glu Ala Val Leu Val Glu Ser Ile Pro Glu Gly Leu Asp Phe Pro 
                85                  90                  95      


Asn Ala Ser Thr Gly Asn Pro Ser Thr Ser Gln Ala Trp Leu Gly Leu 
            100                 105                 110         


Leu Ala Gly Ala His Ser Ser Leu Asp Ile Ala Ser Phe Tyr Trp Thr 
        115                 120                 125             


Leu Thr Asn Asn Asp Thr His Thr Gln Glu Pro Ser Ala Gln Gln Gly 
    130                 135                 140                 


Glu Glu Val Leu Arg Gln Leu Gln Thr Leu Ala Pro Lys Gly Val Asn 
145                 150                 155                 160 


Val Arg Ile Ala Val Ser Lys Pro Ser Gly Pro Gln Pro Gln Ala Asp 
                165                 170                 175     


Leu Gln Ala Leu Leu Gln Ser Gly Ala Gln Val Arg Met Val Asp Met 
            180                 185                 190         


Gln Lys Leu Thr His Gly Val Leu His Thr Lys Phe Trp Val Val Asp 
        195                 200                 205             


Gln Thr His Phe Tyr Leu Gly Ser Ala Asn Met Asp Trp Arg Ser Leu 
    210                 215                 220                 


Thr Gln Val Lys Glu Leu Gly Val Val Met Tyr Asn Cys Ser Cys Leu 
225                 230                 235                 240 


Ala Arg Asp Leu Thr Lys Ile Phe Glu Ala Tyr Trp Phe Leu Gly Gln 
                245                 250                 255     


Ala Gly Ser Ser Ile Pro Ser Thr Trp Pro Arg Phe Tyr Asp Thr Arg 
            260                 265                 270         


Tyr Asn Gln Glu Thr Pro Met Glu Ile Cys Leu Asn Gly Thr Pro Ala 
        275                 280                 285             


Leu Ala Tyr Leu Ala Ser Ala Pro Pro Pro Leu Cys Pro Ser Gly Arg 
    290                 295                 300                 


Thr Pro Asp Leu Lys Ala Leu Leu Asn Val Val Asp Asn Ala Arg Ser 
305                 310                 315                 320 


Phe Ile Tyr Val Ala Val Met Asn Tyr Leu Pro Thr Leu Glu Phe Ser 
                325                 330                 335     


His Pro His Arg Phe Trp Pro Ala Ile Asp Asp Gly Leu Arg Arg Ala 
            340                 345                 350         


Thr Tyr Glu Arg Gly Val Lys Val Arg Leu Leu Ile Ser Cys Trp Gly 
        355                 360                 365             


His Ser Glu Pro Ser Met Arg Ala Phe Leu Leu Ser Leu Ala Ala Leu 
    370                 375                 380                 


Arg Asp Asn His Thr His Ser Asp Ile Gln Val Lys Leu Phe Val Val 
385                 390                 395                 400 


Pro Ala Asp Glu Ala Gln Ala Arg Ile Pro Tyr Ala Arg Val Asn His 
                405                 410                 415     


Asn Lys Tyr Met Val Thr Glu Arg Ala Thr Tyr Ile Gly Thr Ser Asn 
            420                 425                 430         


Trp Ser Gly Asn Tyr Phe Thr Glu Thr Ala Gly Thr Ser Leu Leu Val 
        435                 440                 445             


Thr Gln Asn Gly Arg Gly Gly Leu Arg Ser Gln Leu Glu Ala Ile Phe 
    450                 455                 460                 


Leu Arg Asp Trp Asp Ser Pro Tyr Ser His Asp Leu Asp Thr Ser Ala 
465                 470                 475                 480 


Asp Ser Val Gly Asn Ala Cys Arg Leu Leu 
                485                 490 


<210>  78
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Gly Ala Ser Ala Arg Leu Leu Arg Ala Val Ile Met Gly Ala Pro 
1               5                   10                  15      


Gly Ser Gly Lys Gly Thr Val Ser Ser Arg Ile Thr Thr His Phe Glu 
            20                  25                  30          


Leu Lys His Leu Ser Ser Gly Asp Leu Leu Arg Asp Asn Met Leu Arg 
        35                  40                  45              


Gly Thr Glu Ile Gly Val Leu Ala Lys Ala Phe Ile Asp Gln Gly Lys 
    50                  55                  60                  


Leu Ile Pro Asp Asp Val Met Thr Arg Leu Ala Leu His Glu Leu Lys 
65                  70                  75                  80  


Asn Leu Thr Gln Tyr Ser Trp Leu Leu Asp Gly Phe Pro Arg Thr Leu 
                85                  90                  95      


Pro Gln Ala Glu Ala Leu Asp Arg Ala Tyr Gln Ile Asp Thr Val Ile 
            100                 105                 110         


Asn Leu Asn Val Pro Phe Glu Val Ile Lys Gln Arg Leu Thr Ala Arg 
        115                 120                 125             


Trp Ile His Pro Ala Ser Gly Arg Val Tyr Asn Ile Glu Phe Asn Pro 
    130                 135                 140                 


Pro Lys Thr Val Gly Ile Asp Asp Leu Thr Gly Glu Pro Leu Ile Gln 
145                 150                 155                 160 


Arg Glu Asp Asp Lys Pro Glu Thr Val Ile Lys Arg Leu Lys Ala Tyr 
                165                 170                 175     


Glu Asp Gln Thr Lys Pro Val Leu Glu Tyr Tyr Gln Lys Lys Gly Val 
            180                 185                 190         


Leu Glu Thr Phe Ser Gly Thr Glu Thr Asn Lys Ile Trp Pro Tyr Val 
        195                 200                 205             


Tyr Ala Phe Leu Gln Thr Lys Val Pro Gln Arg Ser Gln Lys Ala Ser 
    210                 215                 220                 


Val Thr Pro 
225         


<210>  79
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Lys Lys Ser Ile Gly Ile Leu Ser Pro Gly Val Ala Leu Gly Met 
1               5                   10                  15      


Ala Gly Ser Ala Met Ser Ser Lys Phe Phe Leu Val Ala Leu Ala Ile 
            20                  25                  30          


Phe Phe Ser Phe Ala Gln Val Val Ile Glu Ala Asn Ser Trp Trp Ser 
        35                  40                  45              


Leu Gly Met Asn Asn Pro Val Gln Met Ser Glu Val Tyr Ile Ile Gly 
    50                  55                  60                  


Ala Gln Pro Leu Cys Ser Gln Leu Ala Gly Leu Ser Gln Gly Gln Lys 
65                  70                  75                  80  


Lys Leu Cys His Leu Tyr Gln Asp His Met Gln Tyr Ile Gly Glu Gly 
                85                  90                  95      


Ala Lys Thr Gly Ile Lys Glu Cys Gln Tyr Gln Phe Arg His Arg Arg 
            100                 105                 110         


Trp Asn Cys Ser Thr Val Asp Asn Thr Ser Val Phe Gly Arg Val Met 
        115                 120                 125             


Gln Ile Gly Ser Arg Glu Thr Ala Phe Thr Tyr Ala Val Ser Ala Ala 
    130                 135                 140                 


Gly Val Val Asn Ala Met Ser Arg Ala Cys Arg Glu Gly Glu Leu Ser 
145                 150                 155                 160 


Thr Cys Gly Cys Ser Arg Ala Ala Arg Pro Lys Asp Leu Pro Arg Asp 
                165                 170                 175     


Trp Leu Trp Gly Gly Cys Gly Asp Asn Ile Asp Tyr Gly Tyr Arg Phe 
            180                 185                 190         


Ala Lys Glu Phe Val Asp Ala Arg Glu Arg Glu Arg Ile His Ala Lys 
        195                 200                 205             


Gly Ser Tyr Glu Ser Ala Arg Ile Leu Met Asn Leu His Asn Asn Glu 
    210                 215                 220                 


Ala Gly Arg Arg Thr Val Tyr Asn Leu Ala Asp Val Ala Cys Lys Cys 
225                 230                 235                 240 


His Gly Val Ser Gly Ser Cys Ser Leu Lys Thr Cys Trp Leu Gln Leu 
                245                 250                 255     


Ala Asp Phe Arg Lys Val Gly Asp Ala Leu Lys Glu Lys Tyr Asp Ser 
            260                 265                 270         


Ala Ala Ala Met Arg Leu Asn Ser Arg Gly Lys Leu Val Gln Val Asn 
        275                 280                 285             


Ser Arg Phe Asn Ser Pro Thr Thr Gln Asp Leu Val Tyr Ile Asp Pro 
    290                 295                 300                 


Ser Pro Asp Tyr Cys Val Arg Asn Glu Ser Thr Gly Ser Leu Gly Thr 
305                 310                 315                 320 


Gln Gly Arg Leu Cys Asn Lys Thr Ser Glu Gly Met Asp Gly Cys Glu 
                325                 330                 335     


Leu Met Cys Cys Gly Arg Gly Tyr Asp Gln Phe Lys Thr Val Gln Thr 
            340                 345                 350         


Glu Arg Cys His Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys Lys 
        355                 360                 365             


Lys Cys Thr Glu Ile Val Asp Gln Phe Val Cys Lys 
    370                 375                 380 


<210>  80
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Asp Ser Lys His Gln Cys Val Lys Leu Asn Asp Gly His Phe Met 
1               5                   10                  15      


Pro Val Leu Gly Phe Gly Thr Tyr Ala Pro Pro Glu Val Pro Arg Ser 
            20                  25                  30          


Lys Ala Leu Glu Val Thr Lys Leu Ala Ile Glu Ala Gly Phe Arg His 
        35                  40                  45              


Ile Asp Ser Ala His Leu Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala 
    50                  55                  60                  


Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe 
65                  70                  75                  80  


Tyr Thr Ser Lys Leu Trp Ser Thr Phe His Arg Pro Glu Leu Val Arg 
                85                  90                  95      


Pro Ala Leu Glu Asn Ser Leu Lys Lys Ala Gln Leu Asp Tyr Val Asp 
            100                 105                 110         


Leu Tyr Leu Ile His Ser Pro Met Ser Leu Lys Pro Gly Glu Glu Leu 
        115                 120                 125             


Ser Pro Thr Asp Glu Asn Gly Lys Val Ile Phe Asp Ile Val Asp Leu 
    130                 135                 140                 


Cys Thr Thr Trp Glu Ala Met Glu Lys Cys Lys Asp Ala Gly Leu Ala 
145                 150                 155                 160 


Lys Ser Ile Gly Val Ser Asn Phe Asn Arg Arg Gln Leu Glu Met Ile 
                165                 170                 175     


Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu 
            180                 185                 190         


Cys His Pro Tyr Phe Asn Arg Ser Lys Leu Leu Asp Phe Cys Lys Ser 
        195                 200                 205             


Lys Asp Ile Val Leu Val Ala Tyr Ser Ala Leu Gly Ser Gln Arg Asp 
    210                 215                 220                 


Lys Arg Trp Val Asp Pro Asn Ser Pro Val Leu Leu Glu Asp Pro Val 
225                 230                 235                 240 


Leu Cys Ala Leu Ala Lys Lys His Lys Arg Thr Pro Ala Leu Ile Ala 
                245                 250                 255     


Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Val Leu Ala Lys Ser Tyr 
            260                 265                 270         


Asn Glu Gln Arg Ile Arg Gln Asn Val Gln Val Phe Glu Phe Gln Leu 
        275                 280                 285             


Thr Ala Glu Asp Met Lys Ala Ile Asp Gly Leu Asp Arg Asn Leu His 
    290                 295                 300                 


Tyr Phe Asn Ser Asp Ser Phe Ala Ser His Pro Asn Tyr Pro Tyr Ser 
305                 310                 315                 320 


Asp Glu Tyr 
            


<210>  81
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Ala Thr Lys Ala Arg Val Met Tyr Asp Phe Ala Ala Glu Pro Gly 
1               5                   10                  15      


Asn Asn Glu Leu Thr Val Asn Glu Gly Glu Ile Ile Thr Ile Thr Asn 
            20                  25                  30          


Pro Asp Val Gly Gly Gly Trp Leu Glu Gly Arg Asn Ile Lys Gly Glu 
        35                  40                  45              


Arg Gly Leu Val Pro Thr Asp Tyr Val Glu Ile Leu Pro Ser Asp Gly 
    50                  55                  60                  


Lys Asp Gln Phe Ser Cys Gly Asn Ser Val Ala Asp Gln Ala Phe Leu 
65                  70                  75                  80  


Asp Ser Leu Ser Ala Ser Thr Ala Gln Ala Ser Ser Ser Ala Ala Ser 
                85                  90                  95      


Asn Asn His Gln Val Gly Ser Gly Asn Asp Pro Trp Ser Ala Trp Ser 
            100                 105                 110         


Ala Ser Lys Ser Gly Asn Trp Glu Ser Ser Glu Gly Trp Gly Ala Gln 
        115                 120                 125             


Pro Glu Gly Ala Gly Ala Gln Arg Asn Thr Asn Thr Pro Asn Asn Trp 
    130                 135                 140                 


Asp Thr Ala Phe Gly His Pro Gln Ala Tyr Gln Gly Pro Ala Thr Gly 
145                 150                 155                 160 


Asp Asp Asp Asp Trp Asp Glu Asp Trp Asp Gly Pro Lys Ser Ser Ser 
                165                 170                 175     


Tyr Phe Lys Asp Ser Glu Ser Ala Asp Ala Gly Gly Ala Gln Arg Gly 
            180                 185                 190         


Asn Ser Arg Ala Ser Ser Ser Ser Met Lys Ile Pro Leu Asn Lys Phe 
        195                 200                 205             


Pro Gly Phe Ala Lys Pro Gly Thr Glu Gln Tyr Leu Leu Ala Lys Gln 
    210                 215                 220                 


Leu Ala Lys Pro Lys Glu Lys Ile Pro Ile Ile Val Gly Asp Tyr Gly 
225                 230                 235                 240 


Pro Met Trp Val Tyr Pro Thr Ser Thr Phe Asp Cys Val Val Ala Asp 
                245                 250                 255     


Pro Arg Lys Gly Ser Lys Met Tyr Gly Leu Lys Ser Tyr Ile Glu Tyr 
            260                 265                 270         


Gln Leu Thr Pro Thr Asn Thr Asn Arg Ser Val Asn His Arg Tyr Lys 
        275                 280                 285             


His Phe Asp Trp Leu Tyr Glu Arg Leu Leu Val Lys Phe Gly Ser Ala 
    290                 295                 300                 


Ile Pro Ile Pro Ser Leu Pro Asp Lys Gln Val Thr Gly Arg Phe Glu 
305                 310                 315                 320 


Glu Glu Phe Ile Lys Met Arg Met Glu Arg Leu Gln Ala Trp Met Thr 
                325                 330                 335     


Arg Met Cys Arg His Pro Val Ile Ser Glu Ser Glu Val Phe Gln Gln 
            340                 345                 350         


Phe Leu Asn Phe Arg Asp Glu Lys Glu Trp Lys Thr Gly Lys Arg Lys 
        355                 360                 365             


Ala Glu Arg Asp Glu Leu Ala Gly Val Met Ile Phe Ser Thr Met Glu 
    370                 375                 380                 


Pro Glu Ala Pro Asp Leu Asp Leu Val Glu Ile Glu Gln Lys Cys Glu 
385                 390                 395                 400 


Ala Val Gly Lys Phe Thr Lys Ala Met Asp Asp Gly Val Lys Glu Leu 
                405                 410                 415     


Leu Thr Val Gly Gln Glu His Trp Lys Arg Cys Thr Gly Pro Leu Pro 
            420                 425                 430         


Lys Glu Tyr Gln Lys Ile Gly Lys Ala Leu Gln Ser Leu Ala Thr Val 
        435                 440                 445             


Phe Ser Ser Ser Gly Tyr Gln Gly Glu Thr Asp Leu Asn Asp Ala Ile 
    450                 455                 460                 


Thr Glu Ala Gly Lys Thr Tyr Glu Glu Ile Ala Ser Leu Val Ala Glu 
465                 470                 475                 480 


Gln Pro Lys Lys Asp Leu His Phe Leu Met Glu Cys Asn His Glu Tyr 
                485                 490                 495     


Lys Gly Phe Leu Gly Cys Phe Pro Asp Ile Ile Gly Thr His Lys Gly 
            500                 505                 510         


Ala Ile Glu Lys Val Lys Glu Ser Asp Lys Leu Val Ala Thr Ser Lys 
        515                 520                 525             


Ile Thr Leu Gln Asp Lys Gln Asn Met Val Lys Arg Val Ser Ile Met 
    530                 535                 540                 


Ser Tyr Ala Leu Gln Ala Glu Met Asn His Phe His Ser Asn Arg Ile 
545                 550                 555                 560 


Tyr Asp Tyr Asn Ser Val Ile Arg Leu Tyr Leu Glu Gln Gln Val Gln 
                565                 570                 575     


Phe Tyr Glu Thr Ile Ala Glu Lys Leu Arg Gln Ala Leu Ser Arg Phe 
            580                 585                 590         


Pro Val Met 
        595 


<210>  82
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Gly Asp Trp Ser Ala Leu Gly Lys Leu Leu Asp Lys Val Gln Ala 
1               5                   10                  15      


Tyr Ser Thr Ala Gly Gly Lys Val Trp Leu Ser Val Leu Phe Ile Phe 
            20                  25                  30          


Arg Ile Leu Leu Leu Gly Thr Ala Val Glu Ser Ala Trp Gly Asp Glu 
        35                  40                  45              


Gln Ser Ala Phe Arg Cys Asn Thr Gln Gln Pro Gly Cys Glu Asn Val 
    50                  55                  60                  


Cys Tyr Asp Lys Ser Phe Pro Ile Ser His Val Arg Phe Trp Val Leu 
65                  70                  75                  80  


Gln Ile Ile Phe Val Ser Val Pro Thr Leu Leu Tyr Leu Ala His Val 
                85                  90                  95      


Phe Tyr Val Met Arg Lys Glu Glu Lys Leu Asn Lys Lys Glu Glu Glu 
            100                 105                 110         


Leu Lys Val Ala Gln Thr Asp Gly Val Asn Val Asp Met His Leu Lys 
        115                 120                 125             


Gln Ile Glu Ile Lys Lys Phe Lys Tyr Gly Ile Glu Glu His Gly Lys 
    130                 135                 140                 


Val Lys Met Arg Gly Gly Leu Leu Arg Thr Tyr Ile Ile Ser Ile Leu 
145                 150                 155                 160 


Phe Lys Ser Ile Phe Glu Val Ala Phe Leu Leu Ile Gln Trp Tyr Ile 
                165                 170                 175     


Tyr Gly Phe Ser Leu Ser Ala Val Tyr Thr Cys Lys Arg Asp Pro Cys 
            180                 185                 190         


Pro His Gln Val Asp Cys Phe Leu Ser Arg Pro Thr Glu Lys Thr Ile 
        195                 200                 205             


Phe Ile Ile Phe Met Leu Val Val Ser Leu Val Ser Leu Ala Leu Asn 
    210                 215                 220                 


Ile Ile Glu Leu Phe Tyr Val Phe Phe Lys Gly Val Lys Asp Arg Val 
225                 230                 235                 240 


Lys Gly Lys Ser Asp Pro Tyr His Ala Thr Ser Gly Ala Leu Ser Pro 
                245                 250                 255     


Ala Lys Asp Cys Gly Ser Gln Lys Tyr Ala Tyr Phe Asn Gly Cys Ser 
            260                 265                 270         


Ser Pro Thr Ala Pro Leu Ser Pro Met Ser Pro Pro Gly Tyr Lys Leu 
        275                 280                 285             


Val Thr Gly Asp Arg Asn Asn Ser Ser Cys Arg Asn Tyr Asn Lys Gln 
    290                 295                 300                 


Ala Ser Glu Gln Asn Trp Ala Asn Tyr Ser Ala Glu Gln Asn Arg Met 
305                 310                 315                 320 


Gly Gln Ala Gly Ser Thr Ile Ser Asn Ser His Ala Gln Pro Phe Asp 
                325                 330                 335     


Phe Pro Asp Asp Asn Gln Asn Ser Lys Lys Leu Ala Ala Gly His Glu 
            340                 345                 350         


Leu Gln Pro Leu Ala Ile Val Asp Gln Arg Pro Ser Ser Arg Ala Ser 
        355                 360                 365             


Ser Arg Ala Ser Ser Arg Pro Arg Pro Asp Asp Leu Glu Ile 
    370                 375                 380         


<210>  83
<211>  1178
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Leu Lys Phe Arg Thr Val His Gly Gly Leu Arg Leu Leu Gly Ile 
1               5                   10                  15      


Arg Arg Thr Ser Thr Ala Pro Ala Ala Ser Pro Asn Val Arg Arg Leu 
            20                  25                  30          


Glu Tyr Lys Pro Ile Lys Lys Val Met Val Ala Asn Arg Gly Glu Ile 
        35                  40                  45              


Ala Ile Arg Val Phe Arg Ala Cys Thr Glu Leu Gly Ile Arg Thr Val 
    50                  55                  60                  


Ala Ile Tyr Ser Glu Gln Asp Thr Gly Gln Met His Arg Gln Lys Ala 
65                  70                  75                  80  


Asp Glu Ala Tyr Leu Ile Gly Arg Gly Leu Ala Pro Val Gln Ala Tyr 
                85                  90                  95      


Leu His Ile Pro Asp Ile Ile Lys Val Ala Lys Glu Asn Asn Val Asp 
            100                 105                 110         


Ala Val His Pro Gly Tyr Gly Phe Leu Ser Glu Arg Ala Asp Phe Ala 
        115                 120                 125             


Gln Ala Cys Gln Asp Ala Gly Val Arg Phe Ile Gly Pro Ser Pro Glu 
    130                 135                 140                 


Val Val Arg Lys Met Gly Asp Lys Val Glu Ala Arg Ala Ile Ala Ile 
145                 150                 155                 160 


Ala Ala Gly Val Pro Val Val Pro Gly Thr Asp Ala Pro Ile Thr Ser 
                165                 170                 175     


Leu His Glu Ala His Glu Phe Ser Asn Thr Tyr Gly Phe Pro Ile Ile 
            180                 185                 190         


Phe Lys Ala Ala Tyr Gly Gly Gly Gly Arg Gly Met Arg Val Val His 
        195                 200                 205             


Ser Tyr Glu Glu Leu Glu Glu Asn Tyr Thr Arg Ala Tyr Ser Glu Ala 
    210                 215                 220                 


Leu Ala Ala Phe Gly Asn Gly Ala Leu Phe Val Glu Lys Phe Ile Glu 
225                 230                 235                 240 


Lys Pro Arg His Ile Glu Val Gln Ile Leu Gly Asp Gln Tyr Gly Asn 
                245                 250                 255     


Ile Leu His Leu Tyr Glu Arg Asp Cys Ser Ile Gln Arg Arg His Gln 
            260                 265                 270         


Lys Val Val Glu Ile Ala Pro Ala Ala His Leu Asp Pro Gln Leu Arg 
        275                 280                 285             


Thr Arg Leu Thr Ser Asp Ser Val Lys Leu Ala Lys Gln Val Gly Tyr 
    290                 295                 300                 


Glu Asn Ala Gly Thr Val Glu Phe Leu Val Asp Arg His Gly Lys His 
305                 310                 315                 320 


Tyr Phe Ile Glu Val Asn Ser Arg Leu Gln Val Glu His Thr Val Thr 
                325                 330                 335     


Glu Glu Ile Thr Asp Val Asp Leu Val His Ala Gln Ile His Val Ala 
            340                 345                 350         


Glu Gly Arg Ser Leu Pro Asp Leu Gly Leu Arg Gln Glu Asn Ile Arg 
        355                 360                 365             


Ile Asn Gly Cys Ala Ile Gln Cys Arg Val Thr Thr Glu Asp Pro Ala 
    370                 375                 380                 


Arg Ser Phe Gln Pro Asp Thr Gly Arg Ile Glu Val Phe Arg Ser Gly 
385                 390                 395                 400 


Glu Gly Met Gly Ile Arg Leu Asp Asn Ala Ser Ala Phe Gln Gly Ala 
                405                 410                 415     


Val Ile Ser Pro His Tyr Asp Ser Leu Leu Val Lys Val Ile Ala His 
            420                 425                 430         


Gly Lys Asp His Pro Thr Ala Ala Thr Lys Met Ser Arg Ala Leu Ala 
        435                 440                 445             


Glu Phe Arg Val Arg Gly Val Lys Thr Asn Ile Ala Phe Leu Gln Asn 
    450                 455                 460                 


Val Leu Asn Asn Gln Gln Phe Leu Ala Gly Thr Val Asp Thr Gln Phe 
465                 470                 475                 480 


Ile Asp Glu Asn Pro Glu Leu Phe Gln Leu Arg Pro Ala Gln Asn Arg 
                485                 490                 495     


Ala Gln Lys Leu Leu His Tyr Leu Gly His Val Met Val Asn Gly Pro 
            500                 505                 510         


Thr Thr Pro Ile Pro Val Lys Ala Ser Pro Ser Pro Thr Asp Pro Val 
        515                 520                 525             


Val Pro Ala Val Pro Ile Gly Pro Pro Pro Ala Gly Phe Arg Asp Ile 
    530                 535                 540                 


Leu Leu Arg Glu Gly Pro Glu Gly Phe Ala Arg Ala Val Arg Asn His 
545                 550                 555                 560 


Pro Gly Leu Leu Leu Met Asp Thr Thr Phe Arg Asp Ala His Gln Ser 
                565                 570                 575     


Leu Leu Ala Thr Arg Val Arg Thr His Asp Leu Lys Lys Ile Ala Pro 
            580                 585                 590         


Tyr Val Ala His Asn Phe Ser Lys Leu Phe Ser Met Glu Asn Trp Gly 
        595                 600                 605             


Gly Ala Thr Phe Asp Val Ala Met Arg Phe Leu Tyr Glu Cys Pro Trp 
    610                 615                 620                 


Arg Arg Leu Gln Glu Leu Arg Glu Leu Ile Pro Asn Ile Pro Phe Gln 
625                 630                 635                 640 


Met Leu Leu Arg Gly Ala Asn Ala Val Gly Tyr Thr Asn Tyr Pro Asp 
                645                 650                 655     


Asn Val Val Phe Lys Phe Cys Glu Val Ala Lys Glu Asn Gly Met Asp 
            660                 665                 670         


Val Phe Arg Val Phe Asp Ser Leu Asn Tyr Leu Pro Asn Met Leu Leu 
        675                 680                 685             


Gly Met Glu Ala Ala Gly Ser Ala Gly Gly Val Val Glu Ala Ala Ile 
    690                 695                 700                 


Ser Tyr Thr Gly Asp Val Ala Asp Pro Ser Arg Thr Lys Tyr Ser Leu 
705                 710                 715                 720 


Gln Tyr Tyr Met Gly Leu Ala Glu Glu Leu Val Arg Ala Gly Thr His 
                725                 730                 735     


Ile Leu Cys Ile Lys Asp Met Ala Gly Leu Leu Lys Pro Thr Ala Cys 
            740                 745                 750         


Thr Met Leu Val Ser Ser Leu Arg Asp Arg Phe Pro Asp Leu Pro Leu 
        755                 760                 765             


His Ile His Thr His Asp Thr Ser Gly Ala Gly Val Ala Ala Met Leu 
    770                 775                 780                 


Ala Cys Ala Gln Ala Gly Ala Asp Val Val Asp Val Ala Ala Asp Ser 
785                 790                 795                 800 


Met Ser Gly Met Thr Ser Gln Pro Ser Met Gly Ala Leu Val Ala Cys 
                805                 810                 815     


Thr Arg Gly Thr Pro Leu Asp Thr Glu Val Pro Met Glu Arg Val Phe 
            820                 825                 830         


Asp Tyr Ser Glu Tyr Trp Glu Gly Ala Arg Gly Leu Tyr Ala Ala Phe 
        835                 840                 845             


Asp Cys Thr Ala Thr Met Lys Ser Gly Asn Ser Asp Val Tyr Glu Asn 
    850                 855                 860                 


Glu Ile Pro Gly Gly Gln Tyr Thr Asn Leu His Phe Gln Ala His Ser 
865                 870                 875                 880 


Met Gly Leu Gly Ser Lys Phe Lys Glu Val Lys Lys Ala Tyr Val Glu 
                885                 890                 895     


Ala Asn Gln Met Leu Gly Asp Leu Ile Lys Val Thr Pro Ser Ser Lys 
            900                 905                 910         


Ile Val Gly Asp Leu Ala Gln Phe Met Val Gln Asn Gly Leu Ser Arg 
        915                 920                 925             


Ala Glu Ala Glu Ala Gln Ala Glu Glu Leu Ser Phe Pro Arg Ser Val 
    930                 935                 940                 


Val Glu Phe Leu Gln Gly Tyr Ile Gly Val Pro His Gly Gly Phe Pro 
945                 950                 955                 960 


Glu Pro Phe Arg Ser Lys Val Leu Lys Asp Leu Pro Arg Val Glu Gly 
                965                 970                 975     


Arg Pro Gly Ala Ser Leu Pro Pro Leu Asp Leu Gln Ala Leu Glu Lys 
            980                 985                 990         


Glu Leu Val Asp Arg His Gly Glu  Glu Val Thr Pro Glu  Asp Val Leu 
        995                 1000                 1005             


Ser Ala  Ala Met Tyr Pro Asp  Val Phe Ala His Phe  Lys Asp Phe 
    1010                 1015                 1020             


Thr Ala  Thr Phe Gly Pro Leu  Asp Ser Leu Asn Thr  Arg Leu Phe 
    1025                 1030                 1035             


Leu Gln  Gly Pro Lys Ile Ala  Glu Glu Phe Glu Val  Glu Leu Glu 
    1040                 1045                 1050             


Arg Gly  Lys Thr Leu His Ile  Lys Ala Leu Ala Val  Ser Asp Leu 
    1055                 1060                 1065             


Asn Arg  Ala Gly Gln Arg Gln  Val Phe Phe Glu Leu  Asn Gly Gln 
    1070                 1075                 1080             


Leu Arg  Ser Ile Leu Val Lys  Asp Thr Gln Ala Met  Lys Glu Met 
    1085                 1090                 1095             


His Phe  His Pro Lys Ala Leu  Lys Asp Val Lys Gly  Gln Ile Gly 
    1100                 1105                 1110             


Ala Pro  Met Pro Gly Lys Val  Ile Asp Ile Lys Val  Val Ala Gly 
    1115                 1120                 1125             


Ala Lys  Val Ala Lys Gly Gln  Pro Leu Cys Val Leu  Ser Ala Met 
    1130                 1135                 1140             


Lys Met  Glu Thr Val Val Thr  Ser Pro Met Glu Gly  Thr Val Arg 
    1145                 1150                 1155             


Lys Val  His Val Thr Lys Asp  Met Thr Leu Glu Gly  Asp Asp Leu 
    1160                 1165                 1170             


Ile Leu  Glu Ile Glu 
    1175             


<210>  84
<211>  911
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Pro Pro Arg Arg Ser Ile Val Glu Val Lys Val Leu Asp Val Gln 
1               5                   10                  15      


Lys Arg Arg Val Pro Asn Lys His Tyr Val Tyr Ile Ile Arg Val Thr 
            20                  25                  30          


Trp Ser Ser Gly Ser Thr Glu Ala Ile Tyr Arg Arg Tyr Ser Lys Phe 
        35                  40                  45              


Phe Asp Leu Gln Met Gln Met Leu Asp Lys Phe Pro Met Glu Gly Gly 
    50                  55                  60                  


Gln Lys Asp Pro Lys Gln Arg Ile Ile Pro Phe Leu Pro Gly Lys Ile 
65                  70                  75                  80  


Leu Phe Arg Arg Ser His Ile Arg Asp Val Ala Val Lys Arg Leu Ile 
                85                  90                  95      


Pro Ile Asp Glu Tyr Cys Lys Ala Leu Ile Gln Leu Pro Pro Tyr Ile 
            100                 105                 110         


Ser Gln Cys Asp Glu Val Leu Gln Phe Phe Glu Thr Arg Pro Glu Asp 
        115                 120                 125             


Leu Asn Pro Pro Lys Glu Glu His Ile Gly Lys Lys Lys Ser Gly Gly 
    130                 135                 140                 


Asp Gln Thr Ser Val Asp Pro Met Val Leu Glu Gln Tyr Val Val Val 
145                 150                 155                 160 


Ala Asn Tyr Gln Lys Gln Glu Ser Ser Glu Ile Ser Leu Ser Val Gly 
                165                 170                 175     


Gln Val Val Asp Ile Ile Glu Lys Asn Glu Ser Gly Trp Trp Phe Val 
            180                 185                 190         


Ser Thr Ala Glu Glu Gln Gly Trp Val Pro Ala Thr Cys Leu Glu Gly 
        195                 200                 205             


Gln Asp Gly Val Gln Asp Glu Phe Ser Leu Gln Pro Glu Glu Glu Glu 
    210                 215                 220                 


Lys Tyr Thr Val Ile Tyr Pro Tyr Thr Ala Arg Asp Gln Asp Glu Met 
225                 230                 235                 240 


Asn Leu Glu Arg Gly Ala Val Val Glu Val Ile Gln Lys Asn Leu Glu 
                245                 250                 255     


Gly Trp Trp Lys Ile Arg Tyr Gln Gly Lys Glu Gly Trp Ala Pro Ala 
            260                 265                 270         


Ser Tyr Leu Lys Lys Asn Ser Gly Glu Pro Leu Pro Pro Lys Pro Gly 
        275                 280                 285             


Pro Gly Ser Pro Ser His Pro Gly Ala Leu Asp Leu Asp Gly Val Ser 
    290                 295                 300                 


Arg Gln Gln Asn Ala Val Gly Arg Glu Lys Glu Leu Leu Ser Ser Gln 
305                 310                 315                 320 


Arg Asp Gly Arg Phe Glu Gly Arg Pro Val Pro Asp Gly Asp Ala Lys 
                325                 330                 335     


Gln Arg Ser Pro Lys Met Arg Gln Arg Pro Pro Pro Arg Arg Asp Met 
            340                 345                 350         


Thr Ile Pro Arg Gly Leu Asn Leu Pro Lys Pro Pro Ile Pro Pro Gln 
        355                 360                 365             


Val Glu Glu Glu Tyr Tyr Thr Ile Ala Glu Phe Gln Thr Thr Ile Pro 
    370                 375                 380                 


Asp Gly Ile Ser Phe Gln Ala Gly Leu Lys Val Glu Val Ile Glu Lys 
385                 390                 395                 400 


Asn Leu Ser Gly Trp Trp Tyr Ile Gln Ile Glu Asp Lys Glu Gly Trp 
                405                 410                 415     


Ala Pro Ala Thr Phe Ile Asp Lys Tyr Lys Lys Thr Ser Asn Ala Ser 
            420                 425                 430         


Arg Pro Asn Phe Leu Ala Pro Leu Pro His Glu Val Thr Gln Leu Arg 
        435                 440                 445             


Leu Gly Glu Ala Ala Ala Leu Glu Asn Asn Thr Gly Ser Glu Ala Thr 
    450                 455                 460                 


Gly Pro Ser Arg Pro Leu Pro Asp Ala Pro His Gly Val Met Asp Ser 
465                 470                 475                 480 


Gly Leu Pro Trp Ser Lys Asp Trp Lys Gly Ser Lys Asp Val Leu Arg 
                485                 490                 495     


Lys Ala Ser Ser Asp Met Ser Ala Ser Ala Gly Tyr Glu Glu Ile Ser 
            500                 505                 510         


Asp Pro Asp Met Glu Glu Lys Pro Ser Leu Pro Pro Arg Lys Glu Ser 
        515                 520                 525             


Ile Ile Lys Ser Glu Gly Glu Leu Leu Glu Arg Glu Arg Glu Arg Gln 
    530                 535                 540                 


Arg Thr Glu Gln Leu Arg Gly Pro Thr Pro Lys Pro Pro Gly Val Ile 
545                 550                 555                 560 


Leu Pro Met Met Pro Ala Lys His Ile Pro Pro Ala Arg Asp Ser Arg 
                565                 570                 575     


Arg Pro Glu Pro Lys Pro Asp Lys Ser Arg Leu Phe Gln Leu Lys Asn 
            580                 585                 590         


Asp Met Gly Leu Glu Cys Gly His Lys Val Leu Ala Lys Glu Val Lys 
        595                 600                 605             


Lys Pro Asn Leu Arg Pro Ile Ser Lys Ser Lys Thr Asp Leu Pro Glu 
    610                 615                 620                 


Glu Lys Pro Asp Ala Thr Pro Gln Asn Pro Phe Leu Lys Ser Arg Pro 
625                 630                 635                 640 


Gln Val Arg Pro Lys Pro Ala Pro Ser Pro Lys Thr Glu Pro Pro Gln 
                645                 650                 655     


Gly Glu Asp Gln Val Asp Ile Cys Asn Leu Arg Ser Lys Leu Arg Pro 
            660                 665                 670         


Ala Lys Ser Gln Asp Lys Ser Leu Leu Asp Gly Glu Gly Pro Gln Ala 
        675                 680                 685             


Val Gly Gly Gln Asp Val Ala Phe Ser Arg Ser Phe Leu Pro Gly Glu 
    690                 695                 700                 


Gly Pro Gly Arg Ala Gln Asp Arg Thr Gly Lys Gln Asp Gly Leu Ser 
705                 710                 715                 720 


Pro Lys Glu Ile Ser Cys Arg Ala Pro Pro Arg Pro Ala Lys Thr Thr 
                725                 730                 735     


Asp Pro Val Ser Lys Ser Val Pro Val Pro Leu Gln Glu Ala Pro Gln 
            740                 745                 750         


Gln Arg Pro Val Val Pro Pro Arg Arg Pro Pro Pro Pro Lys Lys Thr 
        755                 760                 765             


Ser Ser Ser Ser Arg Pro Leu Pro Glu Val Arg Gly Pro Gln Cys Glu 
    770                 775                 780                 


Gly His Glu Ser Arg Ala Ala Pro Thr Pro Gly Arg Ala Leu Leu Val 
785                 790                 795                 800 


Pro Pro Lys Ala Lys Pro Phe Leu Ser Asn Ser Leu Gly Gly Gln Asp 
                805                 810                 815     


Asp Thr Arg Gly Lys Gly Ser Leu Gly Pro Trp Gly Thr Gly Lys Ile 
            820                 825                 830         


Gly Glu Asn Arg Glu Lys Ala Ala Ala Ala Ser Val Pro Asn Ala Asp 
        835                 840                 845             


Gly Leu Lys Asp Ser Leu Tyr Val Ala Val Ala Asp Phe Glu Gly Asp 
    850                 855                 860                 


Lys Asp Thr Ser Ser Phe Gln Glu Gly Thr Val Phe Glu Val Arg Glu 
865                 870                 875                 880 


Lys Asn Ser Ser Gly Trp Trp Phe Cys Gln Val Leu Ser Gly Ala Pro 
                885                 890                 895     


Ser Trp Glu Gly Trp Ile Pro Ser Asn Tyr Leu Arg Lys Lys Pro 
            900                 905                 910     


<210>  85
<211>  1181
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Gly Pro Glu Arg Thr Gly Ala Ala Pro Leu Pro Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Leu Ser Gln Gly Ile Leu Asn Cys Cys Leu Ala Tyr Asn Val 
            20                  25                  30          


Gly Leu Pro Glu Ala Lys Ile Phe Ser Gly Pro Ser Ser Glu Gln Phe 
        35                  40                  45              


Gly Tyr Ala Val Gln Gln Phe Ile Asn Pro Lys Gly Asn Trp Leu Leu 
    50                  55                  60                  


Val Gly Ser Pro Trp Ser Gly Phe Pro Glu Asn Arg Met Gly Asp Val 
65                  70                  75                  80  


Tyr Lys Cys Pro Val Asp Leu Ser Thr Ala Thr Cys Glu Lys Leu Asn 
                85                  90                  95      


Leu Gln Thr Ser Thr Ser Ile Pro Asn Val Thr Glu Met Lys Thr Asn 
            100                 105                 110         


Met Ser Leu Gly Leu Ile Leu Thr Arg Asn Met Gly Thr Gly Gly Phe 
        115                 120                 125             


Leu Thr Cys Gly Pro Leu Trp Ala Gln Gln Cys Gly Asn Gln Tyr Tyr 
    130                 135                 140                 


Thr Thr Gly Val Cys Ser Asp Ile Ser Pro Asp Phe Gln Leu Ser Ala 
145                 150                 155                 160 


Ser Phe Ser Pro Ala Thr Gln Pro Cys Pro Ser Leu Ile Asp Val Val 
                165                 170                 175     


Val Val Cys Asp Glu Ser Asn Ser Ile Tyr Pro Trp Asp Ala Val Lys 
            180                 185                 190         


Asn Phe Leu Glu Lys Phe Val Gln Gly Leu Asp Ile Gly Pro Thr Lys 
        195                 200                 205             


Thr Gln Val Gly Leu Ile Gln Tyr Ala Asn Asn Pro Arg Val Val Phe 
    210                 215                 220                 


Asn Leu Asn Thr Tyr Lys Thr Lys Glu Glu Met Ile Val Ala Thr Ser 
225                 230                 235                 240 


Gln Thr Ser Gln Tyr Gly Gly Asp Leu Thr Asn Thr Phe Gly Ala Ile 
                245                 250                 255     


Gln Tyr Ala Arg Lys Tyr Ala Tyr Ser Ala Ala Ser Gly Gly Arg Arg 
            260                 265                 270         


Ser Ala Thr Lys Val Met Val Val Val Thr Asp Gly Glu Ser His Asp 
        275                 280                 285             


Gly Ser Met Leu Lys Ala Val Ile Asp Gln Cys Asn His Asp Asn Ile 
    290                 295                 300                 


Leu Arg Phe Gly Ile Ala Val Leu Gly Tyr Leu Asn Arg Asn Ala Leu 
305                 310                 315                 320 


Asp Thr Lys Asn Leu Ile Lys Glu Ile Lys Ala Ile Ala Ser Ile Pro 
                325                 330                 335     


Thr Glu Arg Tyr Phe Phe Asn Val Ser Asp Glu Ala Ala Leu Leu Glu 
            340                 345                 350         


Lys Ala Gly Thr Leu Gly Glu Gln Ile Phe Ser Ile Glu Gly Thr Val 
        355                 360                 365             


Gln Gly Gly Asp Asn Phe Gln Met Glu Met Ser Gln Val Gly Phe Ser 
    370                 375                 380                 


Ala Asp Tyr Ser Ser Gln Asn Asp Ile Leu Met Leu Gly Ala Val Gly 
385                 390                 395                 400 


Ala Phe Gly Trp Ser Gly Thr Ile Val Gln Lys Thr Ser His Gly His 
                405                 410                 415     


Leu Ile Phe Pro Lys Gln Ala Phe Asp Gln Ile Leu Gln Asp Arg Asn 
            420                 425                 430         


His Ser Ser Tyr Leu Gly Tyr Ser Val Ala Ala Ile Ser Thr Gly Glu 
        435                 440                 445             


Ser Thr His Phe Val Ala Gly Ala Pro Arg Ala Asn Tyr Thr Gly Gln 
    450                 455                 460                 


Ile Val Leu Tyr Ser Val Asn Glu Asn Gly Asn Ile Thr Val Ile Gln 
465                 470                 475                 480 


Ala His Arg Gly Asp Gln Ile Gly Ser Tyr Phe Gly Ser Val Leu Cys 
                485                 490                 495     


Ser Val Asp Val Asp Lys Asp Thr Ile Thr Asp Val Leu Leu Val Gly 
            500                 505                 510         


Ala Pro Met Tyr Met Ser Asp Leu Lys Lys Glu Glu Gly Arg Val Tyr 
        515                 520                 525             


Leu Phe Thr Ile Lys Lys Gly Ile Leu Gly Gln His Gln Phe Leu Glu 
    530                 535                 540                 


Gly Pro Glu Gly Ile Glu Asn Thr Arg Phe Gly Ser Ala Ile Ala Ala 
545                 550                 555                 560 


Leu Ser Asp Ile Asn Met Asp Gly Phe Asn Asp Val Ile Val Gly Ser 
                565                 570                 575     


Pro Leu Glu Asn Gln Asn Ser Gly Ala Val Tyr Ile Tyr Asn Gly His 
            580                 585                 590         


Gln Gly Thr Ile Arg Thr Lys Tyr Ser Gln Lys Ile Leu Gly Ser Asp 
        595                 600                 605             


Gly Ala Phe Arg Ser His Leu Gln Tyr Phe Gly Arg Ser Leu Asp Gly 
    610                 615                 620                 


Tyr Gly Asp Leu Asn Gly Asp Ser Ile Thr Asp Val Ser Ile Gly Ala 
625                 630                 635                 640 


Phe Gly Gln Val Val Gln Leu Trp Ser Gln Ser Ile Ala Asp Val Ala 
                645                 650                 655     


Ile Glu Ala Ser Phe Thr Pro Glu Lys Ile Thr Leu Val Asn Lys Asn 
            660                 665                 670         


Ala Gln Ile Ile Leu Lys Leu Cys Phe Ser Ala Lys Phe Arg Pro Thr 
        675                 680                 685             


Lys Gln Asn Asn Gln Val Ala Ile Val Tyr Asn Ile Thr Leu Asp Ala 
    690                 695                 700                 


Asp Gly Phe Ser Ser Arg Val Thr Ser Arg Gly Leu Phe Lys Glu Asn 
705                 710                 715                 720 


Asn Glu Arg Cys Leu Gln Lys Asn Met Val Val Asn Gln Ala Gln Ser 
                725                 730                 735     


Cys Pro Glu His Ile Ile Tyr Ile Gln Glu Pro Ser Asp Val Val Asn 
            740                 745                 750         


Ser Leu Asp Leu Arg Val Asp Ile Ser Leu Glu Asn Pro Gly Thr Ser 
        755                 760                 765             


Pro Ala Leu Glu Ala Tyr Ser Glu Thr Ala Lys Val Phe Ser Ile Pro 
    770                 775                 780                 


Phe His Lys Asp Cys Gly Glu Asp Gly Leu Cys Ile Ser Asp Leu Val 
785                 790                 795                 800 


Leu Asp Val Arg Gln Ile Pro Ala Ala Gln Glu Gln Pro Phe Ile Val 
                805                 810                 815     


Ser Asn Gln Asn Lys Arg Leu Thr Phe Ser Val Thr Leu Lys Asn Lys 
            820                 825                 830         


Arg Glu Ser Ala Tyr Asn Thr Gly Ile Val Val Asp Phe Ser Glu Asn 
        835                 840                 845             


Leu Phe Phe Ala Ser Phe Ser Leu Pro Val Asp Gly Thr Glu Val Thr 
    850                 855                 860                 


Cys Gln Val Ala Ala Ser Gln Lys Ser Val Ala Cys Asp Val Gly Tyr 
865                 870                 875                 880 


Pro Ala Leu Lys Arg Glu Gln Gln Val Thr Phe Thr Ile Asn Phe Asp 
                885                 890                 895     


Phe Asn Leu Gln Asn Leu Gln Asn Gln Ala Ser Leu Ser Phe Gln Ala 
            900                 905                 910         


Leu Ser Glu Ser Gln Glu Glu Asn Lys Ala Asp Asn Leu Val Asn Leu 
        915                 920                 925             


Lys Ile Pro Leu Leu Tyr Asp Ala Glu Ile His Leu Thr Arg Ser Thr 
    930                 935                 940                 


Asn Ile Asn Phe Tyr Glu Ile Ser Ser Asp Gly Asn Val Pro Ser Ile 
945                 950                 955                 960 


Val His Ser Phe Glu Asp Val Gly Pro Lys Phe Ile Phe Ser Leu Lys 
                965                 970                 975     


Val Thr Thr Gly Ser Val Pro Val Ser Met Ala Thr Val Ile Ile His 
            980                 985                 990         


Ile Pro Gln Tyr Thr Lys Glu Lys  Asn Pro Leu Met Tyr  Leu Thr Gly 
        995                 1000                 1005             


Val Gln  Thr Asp Lys Ala Gly  Asp Ile Ser Cys Asn  Ala Asp Ile 
    1010                 1015                 1020             


Asn Pro  Leu Lys Ile Gly Gln  Thr Ser Ser Ser Val  Ser Phe Lys 
    1025                 1030                 1035             


Ser Glu  Asn Phe Arg His Thr  Lys Glu Leu Asn Cys  Arg Thr Ala 
    1040                 1045                 1050             


Ser Cys  Ser Asn Val Thr Cys  Trp Leu Lys Asp Val  His Met Lys 
    1055                 1060                 1065             


Gly Glu  Tyr Phe Val Asn Val  Thr Thr Arg Ile Trp  Asn Gly Thr 
    1070                 1075                 1080             


Phe Ala  Ser Ser Thr Phe Gln  Thr Val Gln Leu Thr  Ala Ala Ala 
    1085                 1090                 1095             


Glu Ile  Asn Thr Tyr Asn Pro  Glu Ile Tyr Val Ile  Glu Asp Asn 
    1100                 1105                 1110             


Thr Val  Thr Ile Pro Leu Met  Ile Met Lys Pro Asp  Glu Lys Ala 
    1115                 1120                 1125             


Glu Val  Pro Thr Gly Val Ile  Ile Gly Ser Ile Ile  Ala Gly Ile 
    1130                 1135                 1140             


Leu Leu  Leu Leu Ala Leu Val  Ala Ile Leu Trp Lys  Leu Gly Phe 
    1145                 1150                 1155             


Phe Lys  Arg Lys Tyr Glu Lys  Met Thr Lys Asn Pro  Asp Glu Ile 
    1160                 1165                 1170             


Asp Glu  Thr Thr Glu Leu Ser  Ser 
    1175                 1180     


<210>  86
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Gly Thr Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu 
1               5                   10                  15      


Ser Ile Gln Gln Thr Thr Leu Leu Leu Leu Leu Ser Val Leu Ala Thr 
            20                  25                  30          


Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Arg 
        35                  40                  45              


Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala 
    50                  55                  60                  


Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg 
65                  70                  75                  80  


Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val 
                85                  90                  95      


Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser 
            100                 105                 110         


Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly 
        115                 120                 125             


Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln 
    130                 135                 140                 


Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Thr Arg Gln Pro 
145                 150                 155                 160 


Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu 
                165                 170                 175     


Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp 
            180                 185                 190         


Pro Arg Pro Leu Thr Val Val Ala Val Ala Asn Val Met Ser Ala Val 
        195                 200                 205             


Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu 
    210                 215                 220                 


Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
225                 230                 235                 240 


Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Thr 
                245                 250                 255     


Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile 
            260                 265                 270         


Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala 
        275                 280                 285             


Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
    290                 295                 300                 


Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val 
305                 310                 315                 320 


Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                325                 330                 335     


Thr Ala Leu Gln Trp Leu Leu Leu Leu Phe Thr Arg Tyr Pro Asp Val 
            340                 345                 350         


Gln Thr Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
        355                 360                 365             


Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe 
    370                 375                 380                 


Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro 
385                 390                 395                 400 


His Ala Thr Thr Ala Asn Thr Ser Val Leu Gly Tyr His Ile Pro Lys 
                405                 410                 415     


Asp Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Leu 
            420                 425                 430         


Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys 
        435                 440                 445             


Asp Gly Leu Ile Asn Lys Asp Leu Thr Ser Arg Val Met Ile Phe Ser 
    450                 455                 460                 


Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu 
465                 470                 475                 480 


Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn 
                485                 490                 495     


Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Thr Ile Lys 
            500                 505                 510         


Pro Lys Ser Phe Lys Val Asn Val Thr Leu Arg Glu Ser Met Glu Leu 
        515                 520                 525             


Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Thr Cys Gln 
    530                 535                 540             


<210>  87
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Gly Val Lys Ala Ser Gln Thr Gly Phe Val Val Leu Val Leu Leu 
1               5                   10                  15      


Gln Cys Cys Ser Ala Tyr Lys Leu Val Cys Tyr Tyr Thr Ser Trp Ser 
            20                  25                  30          


Gln Tyr Arg Glu Gly Asp Gly Ser Cys Phe Pro Asp Ala Leu Asp Arg 
        35                  40                  45              


Phe Leu Cys Thr His Ile Ile Tyr Ser Phe Ala Asn Ile Ser Asn Asp 
    50                  55                  60                  


His Ile Asp Thr Trp Glu Trp Asn Asp Val Thr Leu Tyr Gly Met Leu 
65                  70                  75                  80  


Asn Thr Leu Lys Asn Arg Asn Pro Asn Leu Lys Thr Leu Leu Ser Val 
                85                  90                  95      


Gly Gly Trp Asn Phe Gly Ser Gln Arg Phe Ser Lys Ile Ala Ser Asn 
            100                 105                 110         


Thr Gln Ser Arg Arg Thr Phe Ile Lys Ser Val Pro Pro Phe Leu Arg 
        115                 120                 125             


Thr His Gly Phe Asp Gly Leu Asp Leu Ala Trp Leu Tyr Pro Gly Arg 
    130                 135                 140                 


Arg Asp Lys Gln His Phe Thr Thr Leu Ile Lys Glu Met Lys Ala Glu 
145                 150                 155                 160 


Phe Ile Lys Glu Ala Gln Pro Gly Lys Lys Gln Leu Leu Leu Ser Ala 
                165                 170                 175     


Ala Leu Ser Ala Gly Lys Val Thr Ile Asp Ser Ser Tyr Asp Ile Ala 
            180                 185                 190         


Lys Ile Ser Gln His Leu Asp Phe Ile Ser Ile Met Thr Tyr Asp Phe 
        195                 200                 205             


His Gly Ala Trp Arg Gly Thr Thr Gly His His Ser Pro Leu Phe Arg 
    210                 215                 220                 


Gly Gln Glu Asp Ala Ser Pro Asp Arg Phe Ser Asn Thr Asp Tyr Ala 
225                 230                 235                 240 


Val Gly Tyr Met Leu Arg Leu Gly Ala Pro Ala Ser Lys Leu Val Met 
                245                 250                 255     


Gly Ile Pro Thr Phe Gly Arg Ser Phe Thr Leu Ala Ser Ser Glu Thr 
            260                 265                 270         


Gly Val Gly Ala Pro Ile Ser Gly Pro Gly Ile Pro Gly Arg Phe Thr 
        275                 280                 285             


Lys Glu Ala Gly Thr Leu Ala Tyr Tyr Glu Ile Cys Asp Phe Leu Arg 
    290                 295                 300                 


Gly Ala Thr Val His Arg Ile Leu Gly Gln Gln Val Pro Tyr Ala Thr 
305                 310                 315                 320 


Lys Gly Asn Gln Trp Val Gly Tyr Asp Asp Gln Glu Ser Val Lys Ser 
                325                 330                 335     


Lys Val Gln Tyr Leu Lys Asp Arg Gln Leu Ala Gly Ala Met Val Trp 
            340                 345                 350         


Ala Leu Asp Leu Asp Asp Phe Gln Gly Ser Phe Cys Gly Gln Asp Leu 
        355                 360                 365             


Arg Phe Pro Leu Thr Asn Ala Ile Lys Asp Ala Leu Ala Ala Thr 
    370                 375                 380             


<210>  88
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Asn Pro Ala Ala Glu Ala Glu Phe Asn Ile Leu Leu Ala Thr Asp 
1               5                   10                  15      


Ser Tyr Lys Val Thr His Tyr Lys Gln Tyr Pro Pro Asn Thr Ser Lys 
            20                  25                  30          


Val Tyr Ser Tyr Phe Glu Cys Arg Glu Lys Lys Thr Glu Asn Ser Lys 
        35                  40                  45              


Leu Arg Lys Val Lys Tyr Glu Glu Thr Val Phe Tyr Gly Leu Gln Tyr 
    50                  55                  60                  


Ile Leu Asn Lys Tyr Leu Lys Gly Lys Val Val Thr Lys Glu Lys Ile 
65                  70                  75                  80  


Gln Glu Ala Lys Asp Val Tyr Lys Glu His Phe Gln Asp Asp Val Phe 
                85                  90                  95      


Asn Glu Lys Gly Trp Asn Tyr Ile Leu Glu Lys Tyr Asp Gly His Leu 
            100                 105                 110         


Pro Ile Glu Ile Lys Ala Val Pro Glu Gly Phe Val Ile Pro Arg Gly 
        115                 120                 125             


Asn Val Leu Phe Thr Val Glu Asn Thr Asp Pro Glu Cys Tyr Trp Leu 
    130                 135                 140                 


Thr Asn Trp Ile Glu Thr Ile Leu Val Gln Ser Trp Tyr Pro Ile Thr 
145                 150                 155                 160 


Val Ala Thr Asn Ser Arg Glu Gln Lys Lys Ile Leu Ala Lys Tyr Leu 
                165                 170                 175     


Leu Glu Thr Ser Gly Asn Leu Asp Gly Leu Glu Tyr Lys Leu His Asp 
            180                 185                 190         


Phe Gly Tyr Arg Gly Val Ser Ser Gln Glu Thr Ala Gly Ile Gly Ala 
        195                 200                 205             


Ser Ala His Leu Val Asn Phe Lys Gly Thr Asp Thr Val Ala Gly Leu 
    210                 215                 220                 


Ala Leu Ile Lys Lys Tyr Tyr Gly Thr Lys Asp Pro Val Pro Gly Tyr 
225                 230                 235                 240 


Ser Val Pro Ala Ala Glu His Ser Thr Ile Thr Ala Trp Gly Lys Asp 
                245                 250                 255     


His Glu Lys Asp Ala Phe Glu His Ile Val Thr Gln Phe Ser Ser Val 
            260                 265                 270         


Pro Val Ser Val Val Ser Asp Ser Tyr Asp Ile Tyr Asn Ala Cys Glu 
        275                 280                 285             


Lys Ile Trp Gly Glu Asp Leu Arg His Leu Ile Val Ser Arg Ser Thr 
    290                 295                 300                 


Gln Ala Pro Leu Ile Ile Arg Pro Asp Ser Gly Asn Pro Leu Asp Thr 
305                 310                 315                 320 


Val Leu Lys Val Leu Glu Ile Leu Gly Lys Lys Phe Pro Val Thr Glu 
                325                 330                 335     


Asn Ser Lys Gly Tyr Lys Leu Leu Pro Pro Tyr Leu Arg Val Ile Gln 
            340                 345                 350         


Gly Asp Gly Val Asp Ile Asn Thr Leu Gln Glu Ile Val Glu Gly Met 
        355                 360                 365             


Lys Gln Lys Met Trp Ser Ile Glu Asn Ile Ala Phe Gly Ser Gly Gly 
    370                 375                 380                 


Gly Leu Leu Gln Lys Leu Thr Arg Asp Leu Leu Asn Cys Ser Phe Lys 
385                 390                 395                 400 


Cys Ser Tyr Val Val Thr Asn Gly Leu Gly Ile Asn Val Phe Lys Asp 
                405                 410                 415     


Pro Val Ala Asp Pro Asn Lys Arg Ser Lys Lys Gly Arg Leu Ser Leu 
            420                 425                 430         


His Arg Thr Pro Ala Gly Asn Phe Val Thr Leu Glu Glu Gly Lys Gly 
        435                 440                 445             


Asp Leu Glu Glu Tyr Gly Gln Asp Leu Leu His Thr Val Phe Lys Asn 
    450                 455                 460                 


Gly Lys Val Thr Lys Ser Tyr Ser Phe Asp Glu Ile Arg Lys Asn Ala 
465                 470                 475                 480 


Gln Leu Asn Ile Glu Leu Glu Ala Ala His His 
                485                 490     


<210>  89
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Lys Thr Trp Val Lys Ile Val Phe Gly Val Ala Thr Ser Ala Val 
1               5                   10                  15      


Leu Ala Leu Leu Val Met Cys Ile Val Leu Arg Pro Ser Arg Val His 
            20                  25                  30          


Asn Ser Glu Glu Asn Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu 
        35                  40                  45              


Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly 
    50                  55                  60                  


Gln Glu Tyr Leu His Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn 
65                  70                  75                  80  


Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Lys 
                85                  90                  95      


Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser Pro Asp Arg Gln Phe Val 
            100                 105                 110         


Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp Arg Tyr Ser Tyr Thr Ala 
        115                 120                 125             


Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly Glu Phe Val Arg Gly Asn 
    130                 135                 140                 


Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys Trp Ser Pro Val Gly Ser 
145                 150                 155                 160 


Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile Tyr Leu Lys Gln Arg Pro 
                165                 170                 175     


Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn Gly Arg Glu Asn Lys Ile 
            180                 185                 190         


Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu Glu Glu Met Leu Ala Thr 
        195                 200                 205             


Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly Lys Phe Leu Ala Tyr Ala 
    210                 215                 220                 


Glu Phe Asn Asp Thr Asp Ile Pro Val Ile Ala Tyr Ser Tyr Tyr Gly 
225                 230                 235                 240 


Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile Pro Tyr Pro Lys Ala Gly 
                245                 250                 255     


Ala Lys Asn Pro Val Val Arg Ile Phe Ile Ile Asp Thr Thr Tyr Pro 
            260                 265                 270         


Ala Tyr Val Gly Pro Gln Glu Val Pro Val Pro Ala Met Ile Ala Ser 
        275                 280                 285             


Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp Val Thr Asp Glu Arg Val 
    290                 295                 300                 


Cys Leu Gln Trp Leu Lys Arg Val Gln Asn Val Ser Val Leu Ser Ile 
305                 310                 315                 320 


Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp Asp Cys Pro Lys Thr Gln 
                325                 330                 335     


Glu His Ile Glu Glu Ser Arg Thr Gly Trp Ala Gly Gly Phe Phe Val 
            340                 345                 350         


Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile Ser Tyr Tyr Lys Ile Phe 
        355                 360                 365             


Ser Asp Lys Asp Gly Tyr Lys His Ile His Tyr Ile Lys Asp Thr Val 
    370                 375                 380                 


Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys Trp Glu Ala Ile Asn Ile 
385                 390                 395                 400 


Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr Ser Ser Asn Glu Phe Glu 
                405                 410                 415     


Glu Tyr Pro Gly Arg Arg Asn Ile Tyr Arg Ile Ser Ile Gly Ser Tyr 
            420                 425                 430         


Pro Pro Ser Lys Lys Cys Val Thr Cys His Leu Arg Lys Glu Arg Cys 
        435                 440                 445             


Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr Ala Lys Tyr Tyr Ala Leu 
    450                 455                 460                 


Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser Thr Leu His Asp Gly Arg 
465                 470                 475                 480 


Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu Asn Lys Glu Leu Glu Asn 
                485                 490                 495     


Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu Glu Ile Lys Lys Leu Glu 
            500                 505                 510         


Val Asp Glu Ile Thr Leu Trp Tyr Lys Met Ile Leu Pro Pro Gln Phe 
        515                 520                 525             


Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile Gln Val Tyr Gly Gly Pro 
    530                 535                 540                 


Cys Ser Gln Ser Val Arg Ser Val Phe Ala Val Asn Trp Ile Ser Tyr 
545                 550                 555                 560 


Leu Ala Ser Lys Glu Gly Met Val Ile Ala Leu Val Asp Gly Arg Gly 
                565                 570                 575     


Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr Ala Val Tyr Arg Lys Leu 
            580                 585                 590         


Gly Val Tyr Glu Val Glu Asp Gln Ile Thr Ala Val Arg Lys Phe Ile 
        595                 600                 605             


Glu Met Gly Phe Ile Asp Glu Lys Arg Ile Ala Ile Trp Gly Trp Ser 
    610                 615                 620                 


Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu Ala Ser Gly Thr Gly Leu 
625                 630                 635                 640 


Phe Lys Cys Gly Ile Ala Val Ala Pro Val Ser Ser Trp Glu Tyr Tyr 
                645                 650                 655     


Ala Ser Val Tyr Thr Glu Arg Phe Met Gly Leu Pro Thr Lys Asp Asp 
            660                 665                 670         


Asn Leu Glu His Tyr Lys Asn Ser Thr Val Met Ala Arg Ala Glu Tyr 
        675                 680                 685             


Phe Arg Asn Val Asp Tyr Leu Leu Ile His Gly Thr Ala Asp Asp Asn 
    690                 695                 700                 


Val His Phe Gln Asn Ser Ala Gln Ile Ala Lys Ala Leu Val Asn Ala 
705                 710                 715                 720 


Gln Val Asp Phe Gln Ala Met Trp Tyr Ser Asp Gln Asn His Gly Leu 
                725                 730                 735     


Ser Gly Leu Ser Thr Asn His Leu Tyr Thr His Met Thr His Phe Leu 
            740                 745                 750         


Lys Gln Cys Phe Ser Leu Ser Asp 
        755                 760 


<210>  90
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Leu Ser Arg Ala Val Cys Gly Thr Ser Arg Gln Leu Ala Pro Ala 
1               5                   10                  15      


Leu Gly Tyr Leu Gly Ser Arg Gln Lys His Ser Leu Pro Asp Leu Pro 
            20                  25                  30          


Tyr Asp Tyr Gly Ala Leu Glu Pro His Ile Asn Ala Gln Ile Met Gln 
        35                  40                  45              


Leu His His Ser Lys His His Ala Ala Tyr Val Asn Asn Leu Asn Val 
    50                  55                  60                  


Thr Glu Glu Lys Tyr Gln Glu Ala Leu Ala Lys Gly Asp Val Thr Ala 
65                  70                  75                  80  


Gln Ile Ala Leu Gln Pro Ala Leu Lys Phe Asn Gly Gly Gly His Ile 
                85                  90                  95      


Asn His Ser Ile Phe Trp Thr Asn Leu Ser Pro Asn Gly Gly Gly Glu 
            100                 105                 110         


Pro Lys Gly Glu Leu Leu Glu Ala Ile Lys Arg Asp Phe Gly Ser Phe 
        115                 120                 125             


Asp Lys Phe Lys Glu Lys Leu Thr Ala Ala Ser Val Gly Val Gln Gly 
    130                 135                 140                 


Ser Gly Trp Gly Trp Leu Gly Phe Asn Lys Glu Arg Gly His Leu Gln 
145                 150                 155                 160 


Ile Ala Ala Cys Pro Asn Gln Asp Pro Leu Gln Gly Thr Thr Gly Leu 
                165                 170                 175     


Ile Pro Leu Leu Gly Ile Asp Val Trp Glu His Ala Tyr Tyr Leu Gln 
            180                 185                 190         


Tyr Lys Asn Val Arg Pro Asp Tyr Leu Lys Ala Ile Trp Asn Val Ile 
        195                 200                 205             


Asn Trp Glu Asn Val Thr Glu Arg Tyr Met Ala Cys Lys Lys 
    210                 215                 220         


<210>  91
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Asp Ser Lys Tyr Gln Cys Val Lys Leu Asn Asp Gly His Phe Met 
1               5                   10                  15      


Pro Val Leu Gly Phe Gly Thr Tyr Ala Pro Ala Glu Val Pro Lys Ser 
            20                  25                  30          


Lys Ala Leu Glu Ala Thr Lys Leu Ala Ile Glu Ala Gly Phe Arg His 
        35                  40                  45              


Ile Asp Ser Ala His Leu Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala 
    50                  55                  60                  


Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe 
65                  70                  75                  80  


Tyr Thr Ser Lys Leu Trp Cys Asn Ser His Arg Pro Glu Leu Val Arg 
                85                  90                  95      


Pro Ala Leu Glu Arg Ser Leu Lys Asn Leu Gln Leu Asp Tyr Val Asp 
            100                 105                 110         


Leu Tyr Leu Ile His Phe Pro Val Ser Val Lys Pro Gly Glu Glu Val 
        115                 120                 125             


Ile Pro Lys Asp Glu Asn Gly Lys Ile Leu Phe Asp Thr Val Asp Leu 
    130                 135                 140                 


Cys Ala Thr Trp Glu Ala Val Glu Lys Cys Lys Asp Ala Gly Leu Ala 
145                 150                 155                 160 


Lys Ser Ile Gly Val Ser Asn Phe Asn Arg Arg Gln Leu Glu Met Ile 
                165                 170                 175     


Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu 
            180                 185                 190         


Cys His Pro Tyr Phe Asn Gln Arg Lys Leu Leu Asp Phe Cys Lys Ser 
        195                 200                 205             


Lys Asp Ile Val Leu Val Ala Tyr Ser Ala Leu Gly Ser His Arg Glu 
    210                 215                 220                 


Glu Pro Trp Val Asp Pro Asn Ser Pro Val Leu Leu Glu Asp Pro Val 
225                 230                 235                 240 


Leu Cys Ala Leu Ala Lys Lys His Lys Arg Thr Pro Ala Leu Ile Ala 
                245                 250                 255     


Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Val Leu Ala Lys Ser Tyr 
            260                 265                 270         


Asn Glu Gln Arg Ile Arg Gln Asn Val Gln Val Phe Glu Phe Gln Leu 
        275                 280                 285             


Thr Ser Glu Glu Met Lys Ala Ile Asp Gly Leu Asn Arg Asn Val Arg 
    290                 295                 300                 


Tyr Leu Thr Leu Asp Ile Phe Ala Gly Pro Pro Asn Tyr Pro Phe Ser 
305                 310                 315                 320 


Asp Glu Tyr 
            


<210>  92
<211>  1045
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Gly Glu Ile Glu Gln Arg Pro Thr Pro Gly Ser Arg Leu Gly Ala 
1               5                   10                  15      


Pro Glu Asn Ser Gly Ile Ser Thr Leu Glu Arg Gly Gln Lys Pro Pro 
            20                  25                  30          


Pro Thr Pro Ser Gly Lys Leu Val Ser Ile Lys Ile Gln Met Leu Asp 
        35                  40                  45              


Asp Thr Gln Glu Ala Phe Glu Val Pro Gln Arg Ala Pro Gly Lys Val 
    50                  55                  60                  


Leu Leu Asp Ala Val Cys Asn His Leu Asn Leu Val Glu Gly Asp Tyr 
65                  70                  75                  80  


Phe Gly Leu Glu Phe Pro Asp His Lys Lys Ile Thr Val Trp Leu Asp 
                85                  90                  95      


Leu Leu Lys Pro Ile Val Lys Gln Ile Arg Arg Pro Lys His Val Val 
            100                 105                 110         


Val Lys Phe Val Val Lys Phe Phe Pro Pro Asp His Thr Gln Leu Gln 
        115                 120                 125             


Glu Glu Leu Thr Arg Tyr Leu Phe Ala Leu Gln Val Lys Gln Asp Leu 
    130                 135                 140                 


Ala Gln Gly Arg Leu Thr Cys Asn Asp Thr Ser Ala Ala Leu Leu Ile 
145                 150                 155                 160 


Ser His Ile Val Gln Ser Glu Ile Gly Asp Phe Asp Glu Ala Leu Asp 
                165                 170                 175     


Arg Glu His Leu Ala Lys Asn Lys Tyr Ile Pro Gln Gln Asp Ala Leu 
            180                 185                 190         


Glu Asp Lys Ile Val Glu Phe His His Asn His Ile Gly Gln Thr Pro 
        195                 200                 205             


Ala Glu Ser Asp Phe Gln Leu Leu Glu Ile Ala Arg Arg Leu Glu Met 
    210                 215                 220                 


Tyr Gly Ile Arg Leu His Pro Ala Lys Asp Arg Glu Gly Thr Lys Ile 
225                 230                 235                 240 


Asn Leu Ala Val Ala Asn Thr Gly Ile Leu Val Phe Gln Gly Phe Thr 
                245                 250                 255     


Lys Ile Asn Ala Phe Asn Trp Ala Lys Val Arg Lys Leu Ser Phe Lys 
            260                 265                 270         


Arg Lys Arg Phe Leu Ile Lys Leu Arg Pro Asp Ala Asn Ser Ala Tyr 
        275                 280                 285             


Gln Asp Thr Leu Glu Phe Leu Met Ala Ser Arg Asp Phe Cys Lys Ser 
    290                 295                 300                 


Phe Trp Lys Ile Cys Val Glu His His Ala Phe Phe Arg Leu Phe Glu 
305                 310                 315                 320 


Glu Pro Lys Pro Lys Pro Lys Pro Val Leu Phe Ser Arg Gly Ser Ser 
                325                 330                 335     


Phe Arg Phe Ser Gly Arg Thr Gln Lys Gln Val Leu Asp Tyr Val Lys 
            340                 345                 350         


Glu Gly Gly His Lys Lys Val Gln Phe Glu Arg Lys His Ser Lys Ile 
        355                 360                 365             


His Ser Ile Arg Ser Leu Ala Ser Gln Pro Thr Glu Leu Asn Ser Glu 
    370                 375                 380                 


Val Leu Glu Gln Ser Gln Gln Ser Thr Ser Leu Thr Phe Gly Glu Gly 
385                 390                 395                 400 


Ala Glu Ser Pro Gly Gly Gln Ser Cys Arg Arg Gly Lys Glu Pro Lys 
                405                 410                 415     


Val Ser Ala Gly Glu Pro Gly Ser His Pro Ser Pro Ala Pro Arg Arg 
            420                 425                 430         


Ser Pro Ala Gly Asn Lys Gln Ala Asp Gly Ala Ala Ser Ala Pro Thr 
        435                 440                 445             


Glu Glu Glu Glu Glu Val Val Lys Asp Arg Thr Gln Gln Ser Lys Pro 
    450                 455                 460                 


Gln Pro Pro Gln Pro Ser Thr Gly Ser Leu Thr Gly Ser Pro His Leu 
465                 470                 475                 480 


Ser Glu Leu Ser Val Asn Ser Gln Gly Gly Val Ala Pro Ala Asn Val 
                485                 490                 495     


Thr Leu Ser Pro Asn Leu Ser Pro Asp Thr Lys Gln Ala Ser Pro Leu 
            500                 505                 510         


Ile Ser Pro Leu Leu Asn Asp Gln Ala Cys Pro Arg Thr Asp Asp Glu 
        515                 520                 525             


Asp Glu Gly Arg Arg Lys Arg Phe Pro Thr Asp Lys Ala Tyr Phe Ile 
    530                 535                 540                 


Ala Lys Glu Val Ser Thr Thr Glu Arg Thr Tyr Leu Lys Asp Leu Glu 
545                 550                 555                 560 


Val Ile Thr Ser Trp Phe Gln Ser Thr Val Ser Lys Glu Asp Ala Met 
                565                 570                 575     


Pro Glu Ala Leu Lys Ser Leu Ile Phe Pro Asn Phe Glu Pro Leu His 
            580                 585                 590         


Lys Phe His Thr Asn Phe Leu Lys Glu Ile Glu Gln Arg Leu Ala Leu 
        595                 600                 605             


Trp Glu Gly Arg Ser Asn Ala Gln Ile Arg Asp Tyr Gln Arg Ile Gly 
    610                 615                 620                 


Asp Val Met Leu Lys Asn Ile Gln Gly Met Lys His Leu Ala Ala His 
625                 630                 635                 640 


Leu Trp Lys His Ser Glu Ala Leu Glu Ala Leu Glu Asn Gly Ile Lys 
                645                 650                 655     


Ser Ser Arg Arg Leu Glu Asn Phe Cys Arg Asp Phe Glu Leu Gln Lys 
            660                 665                 670         


Val Cys Tyr Leu Pro Leu Asn Thr Phe Leu Leu Arg Pro Leu His Arg 
        675                 680                 685             


Leu Met His Tyr Lys Gln Val Leu Glu Arg Leu Cys Lys His His Pro 
    690                 695                 700                 


Pro Ser His Ala Asp Phe Arg Asp Cys Arg Ala Ala Leu Ala Glu Ile 
705                 710                 715                 720 


Thr Glu Met Val Ala Gln Leu His Gly Thr Met Ile Lys Met Glu Asn 
                725                 730                 735     


Phe Gln Lys Leu His Glu Leu Lys Lys Asp Leu Ile Gly Ile Asp Asn 
            740                 745                 750         


Leu Val Val Pro Gly Arg Glu Phe Ile Arg Leu Gly Ser Leu Ser Lys 
        755                 760                 765             


Leu Ser Gly Lys Gly Leu Gln Gln Arg Met Phe Phe Leu Phe Asn Asp 
    770                 775                 780                 


Val Leu Leu Tyr Thr Ser Arg Gly Leu Thr Ala Ser Asn Gln Phe Lys 
785                 790                 795                 800 


Val His Gly Gln Leu Pro Leu Tyr Gly Met Thr Ile Glu Glu Ser Glu 
                805                 810                 815     


Asp Glu Trp Gly Val Pro His Cys Leu Thr Leu Arg Gly Gln Arg Gln 
            820                 825                 830         


Ser Ile Ile Val Ala Ala Ser Ser Arg Ser Glu Met Glu Lys Trp Val 
        835                 840                 845             


Glu Asp Ile Gln Met Ala Ile Asp Leu Ala Glu Lys Ser Ser Ser Pro 
    850                 855                 860                 


Ala Pro Glu Phe Leu Ala Ser Ser Pro Pro Asp Asn Lys Ser Pro Asp 
865                 870                 875                 880 


Glu Ala Thr Ala Ala Asp Gln Glu Ser Glu Asp Asp Leu Ser Ala Ser 
                885                 890                 895     


Arg Thr Ser Leu Glu Arg Gln Ala Pro His Arg Gly Asn Thr Met Val 
            900                 905                 910         


His Val Cys Trp His Arg Asn Thr Ser Val Ser Met Val Asp Phe Ser 
        915                 920                 925             


Ile Ala Val Glu Asn Gln Leu Ser Gly Asn Leu Leu Arg Lys Phe Lys 
    930                 935                 940                 


Asn Ser Asn Gly Trp Gln Lys Leu Trp Val Val Phe Thr Asn Phe Cys 
945                 950                 955                 960 


Leu Phe Phe Tyr Lys Ser His Gln Asp Asn His Pro Leu Ala Ser Leu 
                965                 970                 975     


Pro Leu Leu Gly Tyr Ser Leu Thr Ile Pro Ser Glu Ser Glu Asn Ile 
            980                 985                 990         


Gln Lys Asp Tyr Val Phe Lys Leu  His Phe Lys Ser His  Val Tyr Tyr 
        995                 1000                 1005             


Phe Arg  Ala Glu Ser Glu Tyr  Thr Phe Glu Arg Trp  Met Glu Val 
    1010                 1015                 1020             


Ile Arg  Ser Ala Thr Ser Ser  Ala Ser Arg Pro His  Val Leu Ser 
    1025                 1030                 1035             


His Lys  Glu Ser Leu Val Tyr  
    1040                 1045 


<210>  93
<211>  544
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Gly Pro Gly Ala Arg Leu Ala Ala Leu Leu Ala Val Leu Ala Leu 
1               5                   10                  15      


Gly Thr Gly Asp Pro Glu Arg Ala Ala Ala Arg Gly Asp Thr Phe Ser 
            20                  25                  30          


Ala Leu Thr Ser Val Ala Arg Ala Leu Ala Pro Glu Arg Arg Leu Leu 
        35                  40                  45              


Gly Leu Leu Arg Arg Tyr Leu Arg Gly Glu Glu Ala Arg Leu Arg Asp 
    50                  55                  60                  


Leu Thr Arg Phe Tyr Asp Lys Val Leu Ser Leu His Glu Asp Ser Thr 
65                  70                  75                  80  


Thr Pro Val Ala Asn Pro Leu Leu Ala Phe Thr Leu Ile Lys Arg Leu 
                85                  90                  95      


Gln Ser Asp Trp Arg Asn Val Val His Ser Leu Glu Ala Ser Glu Asn 
            100                 105                 110         


Ile Arg Ala Leu Lys Asp Gly Tyr Glu Lys Val Glu Gln Asp Leu Pro 
        115                 120                 125             


Ala Phe Glu Asp Leu Glu Gly Ala Ala Arg Ala Leu Met Arg Leu Gln 
    130                 135                 140                 


Asp Val Tyr Met Leu Asn Val Lys Gly Leu Ala Arg Gly Val Phe Gln 
145                 150                 155                 160 


Arg Val Thr Gly Ser Ala Ile Thr Asp Leu Tyr Ser Pro Lys Arg Leu 
                165                 170                 175     


Phe Ser Leu Thr Gly Asp Asp Cys Phe Gln Val Gly Lys Val Ala Tyr 
            180                 185                 190         


Asp Met Gly Asp Tyr Tyr His Ala Ile Pro Trp Leu Glu Glu Ala Val 
        195                 200                 205             


Ser Leu Phe Arg Gly Ser Tyr Gly Glu Trp Lys Thr Glu Asp Glu Ala 
    210                 215                 220                 


Ser Leu Glu Asp Ala Leu Asp His Leu Ala Phe Ala Tyr Phe Arg Ala 
225                 230                 235                 240 


Gly Asn Val Ser Cys Ala Leu Ser Leu Ser Arg Glu Phe Leu Leu Tyr 
                245                 250                 255     


Ser Pro Asp Asn Lys Arg Met Ala Arg Asn Val Leu Lys Tyr Glu Arg 
            260                 265                 270         


Leu Leu Ala Glu Ser Pro Asn His Val Val Ala Glu Ala Val Ile Gln 
        275                 280                 285             


Arg Pro Asn Ile Pro His Leu Gln Thr Arg Asp Thr Tyr Glu Gly Leu 
    290                 295                 300                 


Cys Gln Thr Leu Gly Ser Gln Pro Thr Leu Tyr Gln Ile Pro Ser Leu 
305                 310                 315                 320 


Tyr Cys Ser Tyr Glu Thr Asn Ser Asn Ala Tyr Leu Leu Leu Gln Pro 
                325                 330                 335     


Ile Arg Lys Glu Val Ile His Leu Glu Pro Tyr Ile Ala Leu Tyr His 
            340                 345                 350         


Asp Phe Val Ser Asp Ser Glu Ala Gln Lys Ile Arg Glu Leu Ala Glu 
        355                 360                 365             


Pro Trp Leu Gln Arg Ser Val Val Ala Ser Gly Glu Lys Gln Leu Gln 
    370                 375                 380                 


Val Glu Tyr Arg Ile Ser Lys Ser Ala Trp Leu Lys Asp Thr Val Asp 
385                 390                 395                 400 


Pro Lys Leu Val Thr Leu Asn His Arg Ile Ala Ala Leu Thr Gly Leu 
                405                 410                 415     


Asp Val Arg Pro Pro Tyr Ala Glu Tyr Leu Gln Val Val Asn Tyr Gly 
            420                 425                 430         


Ile Gly Gly His Tyr Glu Pro His Phe Asp His Ala Thr Ser Pro Ser 
        435                 440                 445             


Ser Pro Leu Tyr Arg Met Lys Ser Gly Asn Arg Val Ala Thr Phe Met 
    450                 455                 460                 


Ile Tyr Leu Ser Ser Val Glu Ala Gly Gly Ala Thr Ala Phe Ile Tyr 
465                 470                 475                 480 


Ala Asn Leu Ser Val Pro Val Val Arg Asn Ala Ala Leu Phe Trp Trp 
                485                 490                 495     


Asn Leu His Arg Ser Gly Glu Gly Asp Ser Asp Thr Leu His Ala Gly 
            500                 505                 510         


Cys Pro Val Leu Val Gly Asp Lys Trp Val Ala Asn Lys Trp Ile His 
        515                 520                 525             


Glu Tyr Gly Gln Glu Phe Arg Arg Pro Cys Ser Ser Ser Pro Glu Asp 
    530                 535                 540                 


<210>  94
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Gly Asp Pro Glu Arg Pro Glu Ala Ala Gly Leu Asp Gln Asp Glu 
1               5                   10                  15      


Arg Ser Ser Ser Asp Thr Asn Glu Ser Glu Ile Lys Ser Asn Glu Glu 
            20                  25                  30          


Pro Leu Leu Arg Lys Ser Ser Arg Arg Phe Val Ile Phe Pro Ile Gln 
        35                  40                  45              


Tyr Pro Asp Ile Trp Lys Met Tyr Lys Gln Ala Gln Ala Ser Phe Trp 
    50                  55                  60                  


Thr Ala Glu Glu Val Asp Leu Ser Lys Asp Leu Pro His Trp Asn Lys 
65                  70                  75                  80  


Leu Lys Ala Asp Glu Lys Tyr Phe Ile Ser His Ile Leu Ala Phe Phe 
                85                  90                  95      


Ala Ala Ser Asp Gly Ile Val Asn Glu Asn Leu Val Glu Arg Phe Ser 
            100                 105                 110         


Gln Glu Val Gln Val Pro Glu Ala Arg Cys Phe Tyr Gly Phe Gln Ile 
        115                 120                 125             


Leu Ile Glu Asn Val His Ser Glu Met Tyr Ser Leu Leu Ile Asp Thr 
    130                 135                 140                 


Tyr Ile Arg Asp Pro Lys Lys Arg Glu Phe Leu Phe Asn Ala Ile Glu 
145                 150                 155                 160 


Thr Met Pro Tyr Val Lys Lys Lys Ala Asp Trp Ala Leu Arg Trp Ile 
                165                 170                 175     


Ala Asp Arg Lys Ser Thr Phe Gly Glu Arg Val Val Ala Phe Ala Ala 
            180                 185                 190         


Val Glu Gly Val Phe Phe Ser Gly Ser Phe Ala Ala Ile Phe Trp Leu 
        195                 200                 205             


Lys Lys Arg Gly Leu Met Pro Gly Leu Thr Phe Ser Asn Glu Leu Ile 
    210                 215                 220                 


Ser Arg Asp Glu Gly Leu His Cys Asp Phe Ala Cys Leu Met Phe Gln 
225                 230                 235                 240 


Tyr Leu Val Asn Lys Pro Ser Glu Glu Arg Val Arg Glu Ile Ile Val 
                245                 250                 255     


Asp Ala Val Lys Ile Glu Gln Glu Phe Leu Thr Glu Ala Leu Pro Val 
            260                 265                 270         


Gly Leu Ile Gly Met Asn Cys Ile Leu Met Lys Gln Tyr Ile Glu Phe 
        275                 280                 285             


Val Ala Asp Arg Leu Leu Val Glu Leu Gly Phe Ser Lys Val Phe Gln 
    290                 295                 300                 


Ala Glu Asn Pro Phe Asp Phe Met Glu Asn Ile Ser Leu Glu Gly Lys 
305                 310                 315                 320 


Thr Asn Phe Phe Glu Lys Arg Val Ser Glu Tyr Gln Arg Phe Ala Val 
                325                 330                 335     


Met Ala Glu Thr Thr Asp Asn Val Phe Thr Leu Asp Ala Asp Phe 
            340                 345                 350     


<210>  95
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Ser Gly Arg Ser Gly Lys Lys Lys Met Ser Lys Leu Ser Arg Ser 
1               5                   10                  15      


Ala Arg Ala Gly Val Ile Phe Pro Val Gly Arg Leu Met Arg Tyr Leu 
            20                  25                  30          


Lys Lys Gly Thr Phe Lys Tyr Arg Ile Ser Val Gly Ala Pro Val Tyr 
        35                  40                  45              


Met Ala Ala Val Ile Glu Tyr Leu Ala Ala Glu Ile Leu Glu Leu Ala 
    50                  55                  60                  


Gly Asn Ala Ala Arg Asp Asn Lys Lys Ala Arg Ile Ala Pro Arg His 
65                  70                  75                  80  


Ile Leu Leu Ala Val Ala Asn Asp Glu Glu Leu Asn Gln Leu Leu Lys 
                85                  90                  95      


Gly Val Thr Ile Ala Ser Gly Gly Val Leu Pro Arg Ile His Pro Glu 
            100                 105                 110         


Leu Leu Ala Lys Lys Arg Gly Thr Lys Gly Lys Ser Glu Thr Ile Leu 
        115                 120                 125             


Ser Pro Pro Pro Glu Lys Arg Gly Arg Lys Ala Thr Ser Gly Lys Lys 
    130                 135                 140                 


Gly Gly Lys Lys Ser Lys Ala Ala Lys Pro Arg Thr Ser Lys Lys Ser 
145                 150                 155                 160 


Lys Pro Lys Asp Ser Asp Lys Glu Gly Thr Ser Asn Ser Thr Ser Glu 
                165                 170                 175     


Asp Gly Pro Gly Asp Gly Phe Thr Ile Leu Ser Ser Lys Ser Leu Val 
            180                 185                 190         


Leu Gly Gln Lys Leu Ser Leu Thr Gln Ser Asp Ile Ser His Ile Gly 
        195                 200                 205             


Ser Met Arg Val Glu Gly Ile Val His Pro Thr Thr Ala Glu Ile Asp 
    210                 215                 220                 


Leu Lys Glu Asp Ile Gly Lys Ala Leu Glu Lys Ala Gly Gly Lys Glu 
225                 230                 235                 240 


Phe Leu Glu Thr Val Lys Glu Leu Arg Lys Ser Gln Gly Pro Leu Glu 
                245                 250                 255     


Val Ala Glu Ala Ala Val Ser Gln Ser Ser Gly Leu Ala Ala Lys Phe 
            260                 265                 270         


Val Ile His Cys His Ile Pro Gln Trp Gly Ser Asp Lys Cys Glu Glu 
        275                 280                 285             


Gln Leu Glu Glu Thr Ile Lys Asn Cys Leu Ser Ala Ala Glu Asp Lys 
    290                 295                 300                 


Lys Leu Lys Ser Val Ala Phe Pro Pro Phe Pro Ser Gly Arg Asn Cys 
305                 310                 315                 320 


Phe Pro Lys Gln Thr Ala Ala Gln Val Thr Leu Lys Ala Ile Ser Ala 
                325                 330                 335     


His Phe Asp Asp Ser Ser Ala Ser Ser Leu Lys Asn Val Tyr Phe Leu 
            340                 345                 350         


Leu Phe Asp Ser Glu Ser Ile Gly Ile Tyr Val Gln Glu Met Ala Lys 
        355                 360                 365             


Leu Asp Ala Lys 
    370         


<210>  96
<211>  657
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Gly Cys Cys Ser Ser Ala Ser Ser Ala Ala Gln Ser Ser Lys Arg 
1               5                   10                  15      


Glu Trp Lys Pro Leu Glu Asp Arg Ser Cys Thr Asp Ile Pro Trp Leu 
            20                  25                  30          


Leu Leu Phe Ile Leu Phe Cys Ile Gly Met Gly Phe Ile Cys Gly Phe 
        35                  40                  45              


Ser Ile Ala Thr Gly Ala Ala Ala Arg Leu Val Ser Gly Tyr Asp Ser 
    50                  55                  60                  


Tyr Gly Asn Ile Cys Gly Gln Lys Asn Thr Lys Leu Glu Ala Ile Pro 
65                  70                  75                  80  


Asn Ser Gly Met Asp His Thr Gln Arg Lys Tyr Val Phe Phe Leu Asp 
                85                  90                  95      


Pro Cys Asn Leu Asp Leu Ile Asn Arg Lys Ile Lys Ser Val Ala Leu 
            100                 105                 110         


Cys Val Ala Ala Cys Pro Arg Gln Glu Leu Lys Thr Leu Ser Asp Val 
        115                 120                 125             


Gln Lys Phe Ala Glu Ile Asn Gly Ser Ala Leu Cys Ser Tyr Asn Leu 
    130                 135                 140                 


Lys Pro Ser Glu Tyr Thr Thr Ser Pro Lys Ser Ser Val Leu Cys Pro 
145                 150                 155                 160 


Lys Leu Pro Val Pro Ala Ser Ala Pro Ile Pro Phe Phe His Arg Cys 
                165                 170                 175     


Ala Pro Val Asn Ile Ser Cys Tyr Ala Lys Phe Ala Glu Ala Leu Ile 
            180                 185                 190         


Thr Phe Val Ser Asp Asn Ser Val Leu His Arg Leu Ile Ser Gly Val 
        195                 200                 205             


Met Thr Ser Lys Glu Ile Ile Leu Gly Leu Cys Leu Leu Ser Leu Val 
    210                 215                 220                 


Leu Ser Met Ile Leu Met Val Ile Ile Arg Tyr Ile Ser Arg Val Leu 
225                 230                 235                 240 


Val Trp Ile Leu Thr Ile Leu Val Ile Leu Gly Ser Leu Gly Gly Thr 
                245                 250                 255     


Gly Val Leu Trp Trp Leu Tyr Ala Lys Gln Arg Arg Ser Pro Lys Glu 
            260                 265                 270         


Thr Val Thr Pro Glu Gln Leu Gln Ile Ala Glu Asp Asn Leu Arg Ala 
        275                 280                 285             


Leu Leu Ile Tyr Ala Ile Ser Ala Thr Val Phe Thr Val Ile Leu Phe 
    290                 295                 300                 


Leu Ile Met Leu Val Met Arg Lys Arg Val Ala Leu Thr Ile Ala Leu 
305                 310                 315                 320 


Phe His Val Ala Gly Lys Val Phe Ile His Leu Pro Leu Leu Val Phe 
                325                 330                 335     


Gln Pro Phe Trp Thr Phe Phe Ala Leu Val Leu Phe Trp Val Tyr Trp 
            340                 345                 350         


Ile Met Thr Leu Leu Phe Leu Gly Thr Thr Gly Ser Pro Val Gln Asn 
        355                 360                 365             


Glu Gln Gly Phe Val Glu Phe Lys Ile Ser Gly Pro Leu Gln Tyr Met 
    370                 375                 380                 


Trp Trp Tyr His Val Val Gly Leu Ile Trp Ile Ser Glu Phe Ile Leu 
385                 390                 395                 400 


Ala Cys Gln Gln Met Thr Val Ala Gly Ala Val Val Thr Tyr Tyr Phe 
                405                 410                 415     


Thr Arg Asp Lys Arg Asn Leu Pro Phe Thr Pro Ile Leu Ala Ser Val 
            420                 425                 430         


Asn Arg Leu Ile Arg Tyr His Leu Gly Thr Val Ala Lys Gly Ser Phe 
        435                 440                 445             


Ile Ile Thr Leu Val Lys Ile Pro Arg Met Ile Leu Met Tyr Ile His 
    450                 455                 460                 


Ser Gln Leu Lys Gly Lys Glu Asn Ala Cys Ala Arg Cys Val Leu Lys 
465                 470                 475                 480 


Ser Cys Ile Cys Cys Leu Trp Cys Leu Glu Lys Cys Leu Asn Tyr Leu 
                485                 490                 495     


Asn Gln Asn Ala Tyr Thr Ala Thr Ala Ile Asn Ser Thr Asn Phe Cys 
            500                 505                 510         


Thr Ser Ala Lys Asp Ala Phe Val Ile Leu Val Glu Asn Ala Leu Arg 
        515                 520                 525             


Val Ala Thr Ile Asn Thr Val Gly Asp Phe Met Leu Phe Leu Gly Lys 
    530                 535                 540                 


Val Leu Ile Val Cys Ser Thr Gly Leu Ala Gly Ile Met Leu Leu Asn 
545                 550                 555                 560 


Tyr Gln Gln Asp Tyr Thr Val Trp Val Leu Pro Leu Ile Ile Val Cys 
                565                 570                 575     


Leu Phe Ala Phe Leu Val Ala His Cys Phe Leu Ser Ile Tyr Glu Met 
            580                 585                 590         


Val Val Asp Val Leu Phe Leu Cys Phe Ala Ile Asp Thr Lys Tyr Asn 
        595                 600                 605             


Asp Gly Ser Pro Gly Arg Glu Phe Tyr Met Asp Lys Val Leu Met Glu 
    610                 615                 620                 


Phe Val Glu Asn Ser Arg Lys Ala Met Lys Glu Ala Gly Lys Gly Gly 
625                 630                 635                 640 


Val Ala Asp Ser Arg Glu Leu Lys Pro Met Ala Ser Gly Ala Ser Ser 
                645                 650                 655     


Ala 
    


<210>  97
<211>  1278
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Thr Ala Arg Gly Leu Ala Leu Gly Leu Leu Leu Leu Leu Leu Cys 
1               5                   10                  15      


Pro Ala Gln Val Phe Ser Gln Ser Cys Val Trp Tyr Gly Glu Cys Gly 
            20                  25                  30          


Ile Ala Tyr Gly Asp Lys Arg Tyr Asn Cys Glu Tyr Ser Gly Pro Pro 
        35                  40                  45              


Lys Pro Leu Pro Lys Asp Gly Tyr Asp Leu Val Gln Glu Leu Cys Pro 
    50                  55                  60                  


Gly Phe Phe Phe Gly Asn Val Ser Leu Cys Cys Asp Val Arg Gln Leu 
65                  70                  75                  80  


Gln Thr Leu Lys Asp Asn Leu Gln Leu Pro Leu Gln Phe Leu Ser Arg 
                85                  90                  95      


Cys Pro Ser Cys Phe Tyr Asn Leu Leu Asn Leu Phe Cys Glu Leu Thr 
            100                 105                 110         


Cys Ser Pro Arg Gln Ser Gln Phe Leu Asn Val Thr Ala Thr Glu Asp 
        115                 120                 125             


Tyr Val Asp Pro Val Thr Asn Gln Thr Lys Thr Asn Val Lys Glu Leu 
    130                 135                 140                 


Gln Tyr Tyr Val Gly Gln Ser Phe Ala Asn Ala Met Tyr Asn Ala Cys 
145                 150                 155                 160 


Arg Asp Val Glu Ala Pro Ser Ser Asn Asp Lys Ala Leu Gly Leu Leu 
                165                 170                 175     


Cys Gly Lys Asp Ala Asp Ala Cys Asn Ala Thr Asn Trp Ile Glu Tyr 
            180                 185                 190         


Met Phe Asn Lys Asp Asn Gly Gln Ala Pro Phe Thr Ile Thr Pro Val 
        195                 200                 205             


Phe Ser Asp Phe Pro Val His Gly Met Glu Pro Met Asn Asn Ala Thr 
    210                 215                 220                 


Lys Gly Cys Asp Glu Ser Val Asp Glu Val Thr Ala Pro Cys Ser Cys 
225                 230                 235                 240 


Gln Asp Cys Ser Ile Val Cys Gly Pro Lys Pro Gln Pro Pro Pro Pro 
                245                 250                 255     


Pro Ala Pro Trp Thr Ile Leu Gly Leu Asp Ala Met Tyr Val Ile Met 
            260                 265                 270         


Trp Ile Thr Tyr Met Ala Phe Leu Leu Val Phe Phe Gly Ala Phe Phe 
        275                 280                 285             


Ala Val Trp Cys Tyr Arg Lys Arg Tyr Phe Val Ser Glu Tyr Thr Pro 
    290                 295                 300                 


Ile Asp Ser Asn Ile Ala Phe Ser Val Asn Ala Ser Asp Lys Gly Glu 
305                 310                 315                 320 


Ala Ser Cys Cys Asp Pro Val Ser Ala Ala Phe Glu Gly Cys Leu Arg 
                325                 330                 335     


Arg Leu Phe Thr Arg Trp Gly Ser Phe Cys Val Arg Asn Pro Gly Cys 
            340                 345                 350         


Val Ile Phe Phe Ser Leu Val Phe Ile Thr Ala Cys Ser Ser Gly Leu 
        355                 360                 365             


Val Phe Val Arg Val Thr Thr Asn Pro Val Asp Leu Trp Ser Ala Pro 
    370                 375                 380                 


Ser Ser Gln Ala Arg Leu Glu Lys Glu Tyr Phe Asp Gln His Phe Gly 
385                 390                 395                 400 


Pro Phe Phe Arg Thr Glu Gln Leu Ile Ile Arg Ala Pro Leu Thr Asp 
                405                 410                 415     


Lys His Ile Tyr Gln Pro Tyr Pro Ser Gly Ala Asp Val Pro Phe Gly 
            420                 425                 430         


Pro Pro Leu Asp Ile Gln Ile Leu His Gln Val Leu Asp Leu Gln Ile 
        435                 440                 445             


Ala Ile Glu Asn Ile Thr Ala Ser Tyr Asp Asn Glu Thr Val Thr Leu 
    450                 455                 460                 


Gln Asp Ile Cys Leu Ala Pro Leu Ser Pro Tyr Asn Thr Asn Cys Thr 
465                 470                 475                 480 


Ile Leu Ser Val Leu Asn Tyr Phe Gln Asn Ser His Ser Val Leu Asp 
                485                 490                 495     


His Lys Lys Gly Asp Asp Phe Phe Val Tyr Ala Asp Tyr His Thr His 
            500                 505                 510         


Phe Leu Tyr Cys Val Arg Ala Pro Ala Ser Leu Asn Asp Thr Ser Leu 
        515                 520                 525             


Leu His Asp Pro Cys Leu Gly Thr Phe Gly Gly Pro Val Phe Pro Trp 
    530                 535                 540                 


Leu Val Leu Gly Gly Tyr Asp Asp Gln Asn Tyr Asn Asn Ala Thr Ala 
545                 550                 555                 560 


Leu Val Ile Thr Phe Pro Val Asn Asn Tyr Tyr Asn Asp Thr Glu Lys 
                565                 570                 575     


Leu Gln Arg Ala Gln Ala Trp Glu Lys Glu Phe Ile Asn Phe Val Lys 
            580                 585                 590         


Asn Tyr Lys Asn Pro Asn Leu Thr Ile Ser Phe Thr Ala Glu Arg Ser 
        595                 600                 605             


Ile Glu Asp Glu Leu Asn Arg Glu Ser Asp Ser Asp Val Phe Thr Val 
    610                 615                 620                 


Val Ile Ser Tyr Ala Ile Met Phe Leu Tyr Ile Ser Leu Ala Leu Gly 
625                 630                 635                 640 


His Met Lys Ser Cys Arg Arg Leu Leu Val Asp Ser Lys Val Ser Leu 
                645                 650                 655     


Gly Ile Ala Gly Ile Leu Ile Val Leu Ser Ser Val Ala Cys Ser Leu 
            660                 665                 670         


Gly Val Phe Ser Tyr Ile Gly Leu Pro Leu Thr Leu Ile Val Ile Glu 
        675                 680                 685             


Val Ile Pro Phe Leu Val Leu Ala Val Gly Val Asp Asn Ile Phe Ile 
    690                 695                 700                 


Leu Val Gln Ala Tyr Gln Arg Asp Glu Arg Leu Gln Gly Glu Thr Leu 
705                 710                 715                 720 


Asp Gln Gln Leu Gly Arg Val Leu Gly Glu Val Ala Pro Ser Met Phe 
                725                 730                 735     


Leu Ser Ser Phe Ser Glu Thr Val Ala Phe Phe Leu Gly Ala Leu Ser 
            740                 745                 750         


Val Met Pro Ala Val His Thr Phe Ser Leu Phe Ala Gly Leu Ala Val 
        755                 760                 765             


Phe Ile Asp Phe Leu Leu Gln Ile Thr Cys Phe Val Ser Leu Leu Gly 
    770                 775                 780                 


Leu Asp Ile Lys Arg Gln Glu Lys Asn Arg Leu Asp Ile Phe Cys Cys 
785                 790                 795                 800 


Val Arg Gly Ala Glu Asp Gly Thr Ser Val Gln Ala Ser Glu Ser Cys 
                805                 810                 815     


Leu Phe Arg Phe Phe Lys Asn Ser Tyr Ser Pro Leu Leu Leu Lys Asp 
            820                 825                 830         


Trp Met Arg Pro Ile Val Ile Ala Ile Phe Val Gly Val Leu Ser Phe 
        835                 840                 845             


Ser Ile Ala Val Leu Asn Lys Val Asp Ile Gly Leu Asp Gln Ser Leu 
    850                 855                 860                 


Ser Met Pro Asp Asp Ser Tyr Met Val Asp Tyr Phe Lys Ser Ile Ser 
865                 870                 875                 880 


Gln Tyr Leu His Ala Gly Pro Pro Val Tyr Phe Val Leu Glu Glu Gly 
                885                 890                 895     


His Asp Tyr Thr Ser Ser Lys Gly Gln Asn Met Val Cys Gly Gly Met 
            900                 905                 910         


Gly Cys Asn Asn Asp Ser Leu Val Gln Gln Ile Phe Asn Ala Ala Gln 
        915                 920                 925             


Leu Asp Asn Tyr Thr Arg Ile Gly Phe Ala Pro Ser Ser Trp Ile Asp 
    930                 935                 940                 


Asp Tyr Phe Asp Trp Val Lys Pro Gln Ser Ser Cys Cys Arg Val Asp 
945                 950                 955                 960 


Asn Ile Thr Asp Gln Phe Cys Asn Ala Ser Val Val Asp Pro Ala Cys 
                965                 970                 975     


Val Arg Cys Arg Pro Leu Thr Pro Glu Gly Lys Gln Arg Pro Gln Gly 
            980                 985                 990         


Gly Asp Phe Met Arg Phe Leu Pro  Met Phe Leu Ser Asp  Asn Pro Asn 
        995                 1000                 1005             


Pro Lys  Cys Gly Lys Gly Gly  His Ala Ala Tyr Ser  Ser Ala Val 
    1010                 1015                 1020             


Asn Ile  Leu Leu Gly His Gly  Thr Arg Val Gly Ala  Thr Tyr Phe 
    1025                 1030                 1035             


Met Thr  Tyr His Thr Val Leu  Gln Thr Ser Ala Asp  Phe Ile Asp 
    1040                 1045                 1050             


Ala Leu  Lys Lys Ala Arg Leu  Ile Ala Ser Asn Val  Thr Glu Thr 
    1055                 1060                 1065             


Met Gly  Ile Asn Gly Ser Ala  Tyr Arg Val Phe Pro  Tyr Ser Val 
    1070                 1075                 1080             


Phe Tyr  Val Phe Tyr Glu Gln  Tyr Leu Thr Ile Ile  Asp Asp Thr 
    1085                 1090                 1095             


Ile Phe  Asn Leu Gly Val Ser  Leu Gly Ala Ile Phe  Leu Val Thr 
    1100                 1105                 1110             


Met Val  Leu Leu Gly Cys Glu  Leu Trp Ser Ala Val  Ile Met Cys 
    1115                 1120                 1125             


Ala Thr  Ile Ala Met Val Leu  Val Asn Met Phe Gly  Val Met Trp 
    1130                 1135                 1140             


Leu Trp  Gly Ile Ser Leu Asn  Ala Val Ser Leu Val  Asn Leu Val 
    1145                 1150                 1155             


Met Ser  Cys Gly Ile Ser Val  Glu Phe Cys Ser His  Ile Thr Arg 
    1160                 1165                 1170             


Ala Phe  Thr Val Ser Met Lys  Gly Ser Arg Val Glu  Arg Ala Glu 
    1175                 1180                 1185             


Glu Ala  Leu Ala His Met Gly  Ser Ser Val Phe Ser  Gly Ile Thr 
    1190                 1195                 1200             


Leu Thr  Lys Phe Gly Gly Ile  Val Val Leu Ala Phe  Ala Lys Ser 
    1205                 1210                 1215             


Gln Ile  Phe Gln Ile Phe Tyr  Phe Arg Met Tyr Leu  Ala Met Val 
    1220                 1225                 1230             


Leu Leu  Gly Ala Thr His Gly  Leu Ile Phe Leu Pro  Val Leu Leu 
    1235                 1240                 1245             


Ser Tyr  Ile Gly Pro Ser Val  Asn Lys Ala Lys Ser  Cys Ala Thr 
    1250                 1255                 1260             


Glu Glu  Arg Tyr Lys Gly Thr  Glu Arg Glu Arg Leu  Leu Asn Phe 
    1265                 1270                 1275             


<210>  98
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         


<210>  99
<211>  1190
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Pro Val Arg Gly Asp Arg Gly Phe Pro Pro Arg Arg Glu Leu Ser 
1               5                   10                  15      


Gly Trp Leu Arg Ala Pro Gly Met Glu Glu Leu Ile Trp Glu Gln Tyr 
            20                  25                  30          


Thr Val Thr Leu Gln Lys Asp Ser Lys Arg Gly Phe Gly Ile Ala Val 
        35                  40                  45              


Ser Gly Gly Arg Asp Asn Pro His Phe Glu Asn Gly Glu Thr Ser Ile 
    50                  55                  60                  


Val Ile Ser Asp Val Leu Pro Gly Gly Pro Ala Asp Gly Leu Leu Gln 
65                  70                  75                  80  


Glu Asn Asp Arg Val Val Met Val Asn Gly Thr Pro Met Glu Asp Val 
                85                  90                  95      


Leu His Ser Phe Ala Val Gln Gln Leu Arg Lys Ser Gly Lys Val Ala 
            100                 105                 110         


Ala Ile Val Val Lys Arg Pro Arg Lys Val Gln Val Ala Ala Leu Gln 
        115                 120                 125             


Ala Ser Pro Pro Leu Asp Gln Asp Asp Arg Ala Phe Glu Val Met Asp 
    130                 135                 140                 


Glu Phe Asp Gly Arg Ser Phe Arg Ser Gly Tyr Ser Glu Arg Ser Arg 
145                 150                 155                 160 


Leu Asn Ser His Gly Gly Arg Ser Arg Ser Trp Glu Asp Ser Pro Glu 
                165                 170                 175     


Arg Gly Arg Pro His Glu Arg Ala Arg Ser Arg Glu Arg Asp Leu Ser 
            180                 185                 190         


Arg Asp Arg Ser Arg Gly Arg Ser Leu Glu Arg Gly Leu Asp Gln Asp 
        195                 200                 205             


His Ala Arg Thr Arg Asp Arg Ser Arg Gly Arg Ser Leu Glu Arg Gly 
    210                 215                 220                 


Leu Asp His Asp Phe Gly Pro Ser Arg Asp Arg Asp Arg Asp Arg Ser 
225                 230                 235                 240 


Arg Gly Arg Ser Ile Asp Gln Asp Tyr Glu Arg Ala Tyr His Arg Ala 
                245                 250                 255     


Tyr Asp Pro Asp Tyr Glu Arg Ala Tyr Ser Pro Glu Tyr Arg Arg Gly 
            260                 265                 270         


Ala Arg His Asp Ala Arg Ser Arg Gly Pro Arg Ser Arg Ser Arg Glu 
        275                 280                 285             


His Pro His Ser Arg Ser Pro Ser Pro Glu Pro Arg Gly Arg Pro Gly 
    290                 295                 300                 


Pro Ile Gly Val Leu Leu Met Lys Ser Arg Ala Asn Glu Glu Tyr Gly 
305                 310                 315                 320 


Leu Arg Leu Gly Ser Gln Ile Phe Val Lys Glu Met Thr Arg Thr Gly 
                325                 330                 335     


Leu Ala Thr Lys Asp Gly Asn Leu His Glu Gly Asp Ile Ile Leu Lys 
            340                 345                 350         


Ile Asn Gly Thr Val Thr Glu Asn Met Ser Leu Thr Asp Ala Arg Lys 
        355                 360                 365             


Leu Ile Glu Lys Ser Arg Gly Lys Leu Gln Leu Val Val Leu Arg Asp 
    370                 375                 380                 


Ser Gln Gln Thr Leu Ile Asn Ile Pro Ser Leu Asn Asp Ser Asp Ser 
385                 390                 395                 400 


Glu Ile Glu Asp Ile Ser Glu Ile Glu Ser Asn Arg Ser Phe Ser Pro 
                405                 410                 415     


Glu Glu Arg Arg His Gln Tyr Ser Asp Tyr Asp Tyr His Ser Ser Ser 
            420                 425                 430         


Glu Lys Leu Lys Glu Arg Pro Ser Ser Arg Glu Asp Thr Pro Ser Arg 
        435                 440                 445             


Leu Ser Arg Met Gly Ala Thr Pro Thr Pro Phe Lys Ser Thr Gly Asp 
    450                 455                 460                 


Ile Ala Gly Thr Val Val Pro Glu Thr Asn Lys Glu Pro Arg Tyr Gln 
465                 470                 475                 480 


Glu Asp Pro Pro Ala Pro Gln Pro Lys Ala Ala Pro Arg Thr Phe Leu 
                485                 490                 495     


Arg Pro Ser Pro Glu Asp Glu Ala Ile Tyr Gly Pro Asn Thr Lys Met 
            500                 505                 510         


Val Arg Phe Lys Lys Gly Asp Ser Val Gly Leu Arg Leu Ala Gly Gly 
        515                 520                 525             


Asn Asp Val Gly Ile Phe Val Ala Gly Ile Gln Glu Gly Thr Ser Ala 
    530                 535                 540                 


Glu Gln Glu Gly Leu Gln Glu Gly Asp Gln Ile Leu Lys Val Asn Thr 
545                 550                 555                 560 


Gln Asp Phe Arg Gly Leu Val Arg Glu Asp Ala Val Leu Tyr Leu Leu 
                565                 570                 575     


Glu Ile Pro Lys Gly Glu Met Val Thr Ile Leu Ala Gln Ser Arg Ala 
            580                 585                 590         


Asp Val Tyr Arg Asp Ile Leu Ala Cys Gly Arg Gly Asp Ser Phe Phe 
        595                 600                 605             


Ile Arg Ser His Phe Glu Cys Glu Lys Glu Thr Pro Gln Ser Leu Ala 
    610                 615                 620                 


Phe Thr Arg Gly Glu Val Phe Arg Val Val Asp Thr Leu Tyr Asp Gly 
625                 630                 635                 640 


Lys Leu Gly Asn Trp Leu Ala Val Arg Ile Gly Asn Glu Leu Glu Lys 
                645                 650                 655     


Gly Leu Ile Pro Asn Lys Ser Arg Ala Glu Gln Met Ala Ser Val Gln 
            660                 665                 670         


Asn Ala Gln Arg Asp Asn Ala Gly Asp Arg Ala Asp Phe Trp Arg Met 
        675                 680                 685             


Arg Gly Gln Arg Ser Gly Val Lys Lys Asn Leu Arg Lys Ser Arg Glu 
    690                 695                 700                 


Asp Leu Thr Ala Val Val Ser Val Ser Thr Lys Phe Pro Ala Tyr Glu 
705                 710                 715                 720 


Arg Val Leu Leu Arg Glu Ala Gly Phe Lys Arg Pro Val Val Leu Phe 
                725                 730                 735     


Gly Pro Ile Ala Asp Ile Ala Met Glu Lys Leu Ala Asn Glu Leu Pro 
            740                 745                 750         


Asp Trp Phe Gln Thr Ala Lys Thr Glu Pro Lys Asp Ala Gly Ser Glu 
        755                 760                 765             


Lys Ser Thr Gly Val Val Arg Leu Asn Thr Val Arg Gln Ile Ile Glu 
    770                 775                 780                 


Gln Asp Lys His Ala Leu Leu Asp Val Thr Pro Lys Ala Val Asp Leu 
785                 790                 795                 800 


Leu Asn Tyr Thr Gln Trp Phe Pro Ile Val Ile Phe Phe Asn Pro Asp 
                805                 810                 815     


Ser Arg Gln Gly Val Lys Thr Met Arg Gln Arg Leu Asn Pro Thr Ser 
            820                 825                 830         


Asn Lys Ser Ser Arg Lys Leu Phe Asp Gln Ala Asn Lys Leu Lys Lys 
        835                 840                 845             


Thr Cys Ala His Leu Phe Thr Ala Thr Ile Asn Leu Asn Ser Ala Asn 
    850                 855                 860                 


Asp Ser Trp Phe Gly Ser Leu Lys Asp Thr Ile Gln His Gln Gln Gly 
865                 870                 875                 880 


Glu Ala Val Trp Val Ser Glu Gly Lys Met Glu Gly Met Asp Asp Asp 
                885                 890                 895     


Pro Glu Asp Arg Met Ser Tyr Leu Thr Ala Met Gly Ala Asp Tyr Leu 
            900                 905                 910         


Ser Cys Asp Ser Arg Leu Ile Ser Asp Phe Glu Asp Thr Asp Gly Glu 
        915                 920                 925             


Gly Gly Ala Tyr Thr Asp Asn Glu Leu Asp Glu Pro Ala Glu Glu Pro 
    930                 935                 940                 


Leu Val Ser Ser Ile Thr Arg Ser Ser Glu Pro Val Gln His Glu Glu 
945                 950                 955                 960 


Ser Ile Arg Lys Pro Ser Pro Glu Pro Arg Ala Gln Met Arg Arg Ala 
                965                 970                 975     


Ala Ser Ser Asp Gln Leu Arg Asp Asn Ser Pro Pro Pro Ala Phe Lys 
            980                 985                 990         


Pro Glu Pro Pro Lys Ala Lys Thr  Gln Asn Lys Glu Glu  Ser Tyr Asp 
        995                 1000                 1005             


Phe Ser  Lys Ser Tyr Glu Tyr  Lys Ser Asn Pro Ser  Ala Val Ala 
    1010                 1015                 1020             


Gly Asn  Glu Thr Pro Gly Ala  Ser Thr Lys Gly Tyr  Pro Pro Pro 
    1025                 1030                 1035             


Val Ala  Ala Lys Pro Thr Phe  Gly Arg Ser Ile Leu  Lys Pro Ser 
    1040                 1045                 1050             


Thr Pro  Ile Pro Pro Gln Glu  Gly Glu Glu Val Gly  Glu Ser Ser 
    1055                 1060                 1065             


Glu Glu  Gln Asp Asn Ala Pro  Lys Ser Val Leu Gly  Lys Val Lys 
    1070                 1075                 1080             


Ile Phe  Glu Lys Met Asp His  Lys Ala Arg Leu Gln  Arg Met Gln 
    1085                 1090                 1095             


Glu Leu  Gln Glu Ala Gln Asn  Ala Arg Ile Glu Ile  Ala Gln Lys 
    1100                 1105                 1110             


His Pro  Asp Ile Tyr Ala Val  Pro Ile Lys Thr His  Lys Pro Asp 
    1115                 1120                 1125             


Pro Gly  Thr Pro Gln His Thr  Ser Ser Arg Pro Pro  Glu Pro Gln 
    1130                 1135                 1140             


Lys Ala  Pro Ser Arg Pro Tyr  Gln Asp Thr Arg Gly  Ser Tyr Gly 
    1145                 1150                 1155             


Ser Asp  Ala Glu Glu Glu Glu  Tyr Arg Gln Gln Leu  Ser Glu His 
    1160                 1165                 1170             


Ser Lys  Arg Gly Tyr Tyr Gly  Gln Ser Ala Arg Tyr  Arg Asp Thr 
    1175                 1180                 1185             


Glu Leu  
    1190 


<210>  100
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Leu Lys Lys Gln Ser Ala Gly Leu Val Leu Trp Gly Ala Ile Leu 
1               5                   10                  15      


Phe Val Ala Trp Asn Ala Leu Leu Leu Leu Phe Phe Trp Thr Arg Pro 
            20                  25                  30          


Ala Pro Gly Arg Pro Pro Ser Val Ser Ala Leu Asp Gly Asp Pro Ala 
        35                  40                  45              


Ser Leu Thr Arg Glu Val Ile Arg Leu Ala Gln Asp Ala Glu Val Glu 
    50                  55                  60                  


Leu Glu Arg Gln Arg Gly Leu Leu Gln Gln Ile Gly Asp Ala Leu Ser 
65                  70                  75                  80  


Ser Gln Arg Gly Arg Val Pro Thr Ala Ala Pro Pro Ala Gln Pro Arg 
                85                  90                  95      


Val Pro Val Thr Pro Ala Pro Ala Val Ile Pro Ile Leu Val Ile Ala 
            100                 105                 110         


Cys Asp Arg Ser Thr Val Arg Arg Cys Leu Asp Lys Leu Leu His Tyr 
        115                 120                 125             


Arg Pro Ser Ala Glu Leu Phe Pro Ile Ile Val Ser Gln Asp Cys Gly 
    130                 135                 140                 


His Glu Glu Thr Ala Gln Ala Ile Ala Ser Tyr Gly Ser Ala Val Thr 
145                 150                 155                 160 


His Ile Arg Gln Pro Asp Leu Ser Ser Ile Ala Val Pro Pro Asp His 
                165                 170                 175     


Arg Lys Phe Gln Gly Tyr Tyr Lys Ile Ala Arg His Tyr Arg Trp Ala 
            180                 185                 190         


Leu Gly Gln Val Phe Arg Gln Phe Arg Phe Pro Ala Ala Val Val Val 
        195                 200                 205             


Glu Asp Asp Leu Glu Val Ala Pro Asp Phe Phe Glu Tyr Phe Arg Ala 
    210                 215                 220                 


Thr Tyr Pro Leu Leu Lys Ala Asp Pro Ser Leu Trp Cys Val Ser Ala 
225                 230                 235                 240 


Trp Asn Asp Asn Gly Lys Glu Gln Met Val Asp Ala Ser Arg Pro Glu 
                245                 250                 255     


Leu Leu Tyr Arg Thr Asp Phe Phe Pro Gly Leu Gly Trp Leu Leu Leu 
            260                 265                 270         


Ala Glu Leu Trp Ala Glu Leu Glu Pro Lys Trp Pro Lys Ala Phe Trp 
        275                 280                 285             


Asp Asp Trp Met Arg Arg Pro Glu Gln Arg Gln Gly Arg Ala Cys Ile 
    290                 295                 300                 


Arg Pro Glu Ile Ser Arg Thr Met Thr Phe Gly Arg Lys Gly Val Ser 
305                 310                 315                 320 


His Gly Gln Phe Phe Asp Gln His Leu Lys Phe Ile Lys Leu Asn Gln 
                325                 330                 335     


Gln Phe Val His Phe Thr Gln Leu Asp Leu Ser Tyr Leu Gln Arg Glu 
            340                 345                 350         


Ala Tyr Asp Arg Asp Phe Leu Ala Arg Val Tyr Gly Ala Pro Gln Leu 
        355                 360                 365             


Gln Val Glu Lys Val Arg Thr Asn Asp Arg Lys Glu Leu Gly Glu Val 
    370                 375                 380                 


Arg Val Gln Tyr Thr Gly Arg Asp Ser Phe Lys Ala Phe Ala Lys Ala 
385                 390                 395                 400 


Leu Gly Val Met Asp Asp Leu Lys Ser Gly Val Pro Arg Ala Gly Tyr 
                405                 410                 415     


Arg Gly Ile Val Thr Phe Gln Phe Arg Gly Arg Arg Val His Leu Ala 
            420                 425                 430         


Pro Pro Leu Thr Trp Glu Gly Tyr Asp Pro Ser Trp Asn 
        435                 440                 445 


<210>  101
<211>  917
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Ala Asp Glu Ala Leu Ala Gly Leu Asp Glu Gly Ala Leu Arg Lys 
1               5                   10                  15      


Leu Leu Glu Val Thr Ala Asp Leu Ala Glu Arg Arg Arg Ile Arg Ser 
            20                  25                  30          


Ala Ile Arg Glu Leu Gln Arg Gln Glu Leu Glu Arg Glu Glu Glu Ala 
        35                  40                  45              


Leu Ala Ser Lys Arg Phe Arg Ala Glu Arg Gln Asp Asn Lys Glu Asn 
    50                  55                  60                  


Trp Leu His Ser Gln Gln Arg Glu Ala Glu Gln Arg Ala Ala Leu Ala 
65                  70                  75                  80  


Arg Leu Ala Gly Gln Leu Glu Ser Met Asn Asp Val Glu Glu Leu Thr 
                85                  90                  95      


Ala Leu Leu Arg Ser Ala Gly Glu Tyr Glu Glu Arg Lys Leu Ile Arg 
            100                 105                 110         


Ala Ala Ile Arg Arg Val Arg Ala Gln Glu Ile Glu Ala Ala Thr Leu 
        115                 120                 125             


Ala Gly Arg Leu Tyr Ser Gly Arg Pro Asn Ser Gly Ser Arg Glu Asp 
    130                 135                 140                 


Ser Lys Gly Leu Ala Ala His Arg Leu Glu Gln Cys Glu Val Pro Glu 
145                 150                 155                 160 


Arg Glu Glu Gln Glu Gln Gln Ala Glu Val Ser Lys Pro Thr Pro Thr 
                165                 170                 175     


Pro Glu Gly Thr Ser Gln Asp Val Thr Thr Val Thr Leu Leu Leu Arg 
            180                 185                 190         


Ala Pro Pro Gly Ser Thr Ser Ser Ser Pro Ala Ser Pro Ser Ser Ser 
        195                 200                 205             


Pro Thr Pro Ala Ser Pro Glu Pro Pro Leu Glu Pro Ala Glu Ala Gln 
    210                 215                 220                 


Cys Leu Thr Ala Glu Val Pro Gly Ser Pro Glu Pro Pro Pro Ser Pro 
225                 230                 235                 240 


Pro Lys Thr Thr Ser Pro Glu Pro Gln Glu Ser Pro Thr Leu Pro Ser 
                245                 250                 255     


Thr Glu Gly Gln Val Val Asn Lys Leu Leu Ser Gly Pro Lys Glu Thr 
            260                 265                 270         


Pro Ala Ala Gln Ser Pro Thr Arg Gly Pro Ser Asp Thr Lys Arg Ala 
        275                 280                 285             


Asp Val Ala Gly Pro Arg Pro Cys Gln Arg Ser Leu Ser Val Leu Ser 
    290                 295                 300                 


Pro Arg Gln Pro Ala Gln Asn Arg Glu Ser Thr Pro Leu Ala Ser Gly 
305                 310                 315                 320 


Pro Ser Ser Phe Gln Arg Ala Gly Ser Val Arg Asp Arg Val His Lys 
                325                 330                 335     


Phe Thr Ser Asp Ser Pro Met Ala Ala Arg Leu Gln Asp Gly Thr Pro 
            340                 345                 350         


Gln Ala Ala Leu Ser Pro Leu Thr Pro Ala Arg Leu Leu Gly Pro Ser 
        355                 360                 365             


Leu Thr Ser Thr Thr Pro Ala Ser Ser Ser Ser Gly Ser Ser Ser Arg 
    370                 375                 380                 


Gly Pro Ser Asp Thr Ser Ser Arg Phe Ser Lys Glu Gln Arg Gly Val 
385                 390                 395                 400 


Ala Gln Pro Leu Ala Gln Leu Arg Ser Cys Pro Gln Glu Glu Gly Pro 
                405                 410                 415     


Arg Gly Arg Gly Leu Ala Ala Arg Pro Leu Glu Asn Arg Ala Gly Gly 
            420                 425                 430         


Pro Val Ala Arg Ser Glu Glu Pro Gly Ala Pro Leu Pro Val Ala Val 
        435                 440                 445             


Gly Thr Ala Glu Pro Gly Gly Ser Met Lys Thr Thr Phe Thr Ile Glu 
    450                 455                 460                 


Ile Lys Asp Gly Arg Gly Gln Ala Ser Thr Gly Arg Val Leu Leu Pro 
465                 470                 475                 480 


Thr Gly Asn Gln Arg Ala Glu Leu Thr Leu Gly Leu Arg Ala Pro Pro 
                485                 490                 495     


Thr Leu Leu Ser Thr Ser Ser Gly Gly Lys Ser Thr Ile Thr Arg Val 
            500                 505                 510         


Asn Ser Pro Gly Thr Leu Ala Arg Leu Gly Ser Val Thr His Val Thr 
        515                 520                 525             


Ser Phe Ser His Ala Pro Pro Ser Ser Arg Gly Gly Cys Ser Ile Lys 
    530                 535                 540                 


Met Glu Ala Glu Pro Ala Glu Pro Leu Ala Ala Ala Val Glu Ala Ala 
545                 550                 555                 560 


Asn Gly Ala Glu Gln Thr Arg Val Asn Lys Ala Pro Glu Gly Arg Ser 
                565                 570                 575     


Pro Leu Ser Ala Glu Glu Leu Met Thr Ile Glu Asp Glu Gly Val Leu 
            580                 585                 590         


Asp Lys Met Leu Asp Gln Ser Thr Asp Phe Glu Glu Arg Lys Leu Ile 
        595                 600                 605             


Arg Ala Ala Leu Arg Glu Leu Arg Gln Arg Lys Arg Asp Gln Arg Asp 
    610                 615                 620                 


Lys Glu Arg Glu Arg Arg Leu Gln Glu Ala Arg Gly Arg Pro Gly Glu 
625                 630                 635                 640 


Gly Arg Gly Asn Thr Ala Thr Glu Thr Thr Thr Arg His Ser Gln Arg 
                645                 650                 655     


Ala Ala Asp Gly Ser Ala Val Ser Thr Val Thr Lys Thr Glu Arg Leu 
            660                 665                 670         


Val His Ser Asn Asp Gly Thr Arg Thr Ala Arg Thr Thr Thr Val Glu 
        675                 680                 685             


Ser Ser Phe Val Arg Arg Ser Glu Asn Gly Ser Gly Ser Thr Met Met 
    690                 695                 700                 


Gln Thr Lys Thr Phe Ser Ser Ser Ser Ser Ser Lys Lys Met Gly Ser 
705                 710                 715                 720 


Ile Phe Asp Arg Glu Asp Gln Ala Ser Pro Arg Ala Gly Ser Leu Ala 
                725                 730                 735     


Ala Leu Glu Lys Arg Gln Ala Glu Lys Lys Lys Glu Leu Met Lys Ala 
            740                 745                 750         


Gln Ser Leu Pro Lys Thr Ser Ala Ser Gln Ala Arg Lys Ala Met Ile 
        755                 760                 765             


Glu Lys Leu Glu Lys Glu Gly Ala Ala Gly Ser Pro Gly Gly Pro Arg 
    770                 775                 780                 


Ala Ala Val Gln Arg Ser Thr Ser Phe Gly Val Pro Asn Ala Asn Ser 
785                 790                 795                 800 


Ile Lys Gln Met Leu Leu Asp Trp Cys Arg Ala Lys Thr Arg Gly Tyr 
                805                 810                 815     


Glu His Val Asp Ile Gln Asn Phe Ser Ser Ser Trp Ser Asp Gly Met 
            820                 825                 830         


Ala Phe Cys Ala Leu Val His Asn Phe Phe Pro Glu Ala Phe Asp Tyr 
        835                 840                 845             


Gly Gln Leu Ser Pro Gln Asn Arg Arg Gln Asn Phe Glu Val Ala Phe 
    850                 855                 860                 


Ser Ser Ala Glu Met Leu Val Asp Cys Val Pro Leu Val Glu Val Asp 
865                 870                 875                 880 


Asp Met Met Ile Met Gly Lys Lys Pro Asp Pro Lys Cys Val Phe Thr 
                885                 890                 895     


Tyr Val Gln Ser Leu Tyr Asn His Leu Arg Arg His Glu Leu Arg Leu 
            900                 905                 910         


Arg Gly Lys Asn Val 
        915         


<210>  102
<211>  2579
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ala Glu Ala Val Lys Pro Gln Arg Arg Ala Lys Ala Lys Ala Ser 
1               5                   10                  15      


Arg Thr Lys Thr Lys Glu Lys Lys Lys Tyr Glu Thr Pro Gln Arg Glu 
            20                  25                  30          


Glu Ser Ser Glu Val Ser Leu Pro Lys Thr Ser Arg Glu Gln Glu Ile 
        35                  40                  45              


Pro Ser Leu Ala Cys Glu Phe Lys Gly Asp His Leu Lys Val Val Thr 
    50                  55                  60                  


Asp Ser Gln Leu Gln Asp Asp Ala Ser Gly Gln Asn Glu Ser Glu Met 
65                  70                  75                  80  


Phe Asp Val Pro Leu Thr Ser Leu Thr Ile Ser Asn Glu Glu Ser Leu 
                85                  90                  95      


Thr Cys Asn Thr Glu Pro Pro Lys Glu Gly Gly Glu Ala Arg Pro Cys 
            100                 105                 110         


Val Gly Asp Ser Ala Val Thr Pro Lys Val His Pro Gly Asp Asn Val 
        115                 120                 125             


Gly Thr Lys Val Glu Thr Pro Lys Asn Phe Thr Glu Val Glu Glu Asn 
    130                 135                 140                 


Met Ser Val Gln Gly Gly Leu Ser Glu Ser Ala Pro Gln Ser Asn Phe 
145                 150                 155                 160 


Ser Tyr Thr Gln Pro Ala Met Glu Asn Ile Gln Val Arg Glu Thr Gln 
                165                 170                 175     


Asn Ser Lys Glu Asp Lys Gln Gly Leu Val Cys Ser Ser Glu Val Pro 
            180                 185                 190         


Gln Asn Val Gly Leu Gln Ser Ser Cys Pro Ala Lys His Gly Phe Gln 
        195                 200                 205             


Thr Pro Arg Val Lys Lys Leu Tyr Pro Gln Leu Pro Ala Glu Ile Ala 
    210                 215                 220                 


Gly Glu Ala Pro Ala Leu Val Ala Val Lys Pro Leu Leu Arg Ser Glu 
225                 230                 235                 240 


Arg Leu Tyr Pro Glu Leu Pro Ser Gln Leu Glu Leu Val Pro Phe Thr 
                245                 250                 255     


Lys Glu Gln Leu Lys Ile Leu Glu Pro Gly Ser Trp Leu Glu Asn Val 
            260                 265                 270         


Glu Ser Tyr Leu Glu Glu Phe Asp Ser Met Ala His Gln Asp Arg His 
        275                 280                 285             


Glu Phe Tyr Glu Leu Leu Leu Asn Tyr Ser Arg Cys Arg Lys Gln Leu 
    290                 295                 300                 


Leu Leu Ala Glu Ala Glu Leu Leu Thr Leu Thr Ser Asp Cys Gln Asn 
305                 310                 315                 320 


Ala Lys Ser Arg Leu Trp Gln Phe Lys Glu Glu Gln Met Ser Val Gln 
                325                 330                 335     


Gly Ile Cys Ala Asp Gln Val Lys Val Phe Ser Tyr His Arg Tyr Gln 
            340                 345                 350         


Arg Val Glu Met Asn Glu Asn Ala Leu Val Glu Leu Lys Lys Leu Phe 
        355                 360                 365             


Asp Ala Lys Ser Glu His Leu His Gln Thr Leu Ala Leu His Ser Tyr 
    370                 375                 380                 


Thr Ser Val Leu Ser Arg Leu Gln Val Glu Ser Tyr Ile Tyr Ala Leu 
385                 390                 395                 400 


Leu Ser Ser Ser Ala Val Leu Arg Ser Ser Ala Ile His Gln Gln Gly 
                405                 410                 415     


Arg Ala Ser Lys Gln Thr Glu Ser Ile Pro Ser Asp Leu Cys Gln Leu 
            420                 425                 430         


Lys Glu Cys Ile Ser Val Leu Phe Met Phe Thr Arg Arg Val Asn Glu 
        435                 440                 445             


Asp Thr Gln Phe His Asp Asp Ile Leu Leu Trp Leu Gln Lys Leu Val 
    450                 455                 460                 


Ser Val Leu Gln Arg Val Gly Cys Pro Gly Asp His Leu Phe Leu Leu 
465                 470                 475                 480 


Asn His Ile Leu Arg Cys Pro Ala Gly Val Ser Lys Trp Ala Val Pro 
                485                 490                 495     


Phe Ile Gln Ile Lys Val Leu His Asn Pro Ser Gly Val Phe His Phe 
            500                 505                 510         


Met Gln Ser Leu Ala Leu Leu Met Ser Pro Val Lys Asn Arg Ala Glu 
        515                 520                 525             


Phe Met Cys His Met Lys Pro Ser Glu Arg Lys Pro Ser Ser Ser Gly 
    530                 535                 540                 


Pro Gly Ser Gly Thr Trp Thr Leu Val Asp Glu Gly Gly Glu Glu Asp 
545                 550                 555                 560 


Glu Asp Pro Glu Thr Ser Trp Ile Leu Leu Asn Glu Asp Asp Leu Val 
                565                 570                 575     


Thr Ile Leu Ala Gln Phe Pro Phe His Glu Leu Phe Gln His Leu Leu 
            580                 585                 590         


Gly Phe Lys Ala Lys Gly Asp Tyr Leu Pro Glu Thr Thr Arg Pro Gln 
        595                 600                 605             


Glu Met Met Lys Ile Phe Ala Phe Ala Asn Ser Leu Val Glu Leu Leu 
    610                 615                 620                 


Ala Val Gly Leu Glu Thr Phe Asn Arg Ala Arg Tyr Arg Gln Phe Val 
625                 630                 635                 640 


Lys Arg Ile Gly Tyr Met Ile Arg Met Thr Leu Gly Tyr Val Ser Asp 
                645                 650                 655     


His Trp Ala Gln Tyr Val Ser His Asn Gln Gly Ser Gly Leu Ala Gln 
            660                 665                 670         


Gln Pro Tyr Ser Met Glu Lys Leu Gln Val Glu Phe Asp Glu Leu Phe 
        675                 680                 685             


Leu Arg Ala Val Leu His Val Leu Lys Ala Lys Arg Leu Gly Ile Trp 
    690                 695                 700                 


Leu Phe Met Ser Glu Met Pro Phe Gly Thr Leu Ser Val Gln Met Leu 
705                 710                 715                 720 


Trp Lys Leu Phe Tyr Leu Met His Gln Val Glu Ser Glu Asn Leu Gln 
                725                 730                 735     


Gln Leu Ser Ser Ser Leu Gln Pro Ala Gln Cys Lys Gln Gln Leu Gln 
            740                 745                 750         


Asp Pro Glu His Phe Thr Asn Phe Glu Lys Cys Leu Ser Ser Met Asn 
        755                 760                 765             


Ser Ser Glu Glu Ile Cys Leu Leu Thr Thr Phe Ala Gln Met Ala Gln 
    770                 775                 780                 


Ala Arg Arg Thr Asn Val Asp Glu Asp Phe Ile Lys Ile Ile Val Leu 
785                 790                 795                 800 


Glu Ile Tyr Glu Val Ser Tyr Val Thr Leu Ser Thr Arg Glu Thr Phe 
                805                 810                 815     


Ser Lys Val Gly Arg Glu Leu Leu Gly Thr Ile Thr Ala Val His Pro 
            820                 825                 830         


Glu Ile Ile Ser Val Leu Leu Asp Arg Val Gln Glu Thr Ile Asp Gln 
        835                 840                 845             


Val Gly Met Val Ser Leu Tyr Leu Phe Lys Glu Leu Pro Leu Tyr Leu 
    850                 855                 860                 


Trp Gln Pro Ser Ala Ser Glu Ile Ala Val Ile Arg Asp Trp Leu Leu 
865                 870                 875                 880 


Asn Tyr Asn Leu Thr Val Val Lys Asn Lys Leu Ala Cys Val Ile Leu 
                885                 890                 895     


Glu Gly Leu Asn Trp Gly Phe Ala Lys Gln Ala Thr Leu His Leu Asp 
            900                 905                 910         


Gln Ala Val His Ala Glu Val Ala Leu Met Val Leu Glu Ala Tyr Gln 
        915                 920                 925             


Lys Tyr Leu Ala Gln Lys Pro Tyr Ala Gly Ile Leu Ser Glu Ser Met 
    930                 935                 940                 


Lys Gln Val Ser Tyr Leu Ala Ser Ile Val Arg Tyr Gly Glu Thr Pro 
945                 950                 955                 960 


Glu Thr Ser Phe Asn Gln Trp Ala Trp Asn Leu Ile Leu Arg Leu Lys 
                965                 970                 975     


Leu His Lys Asn Asp Tyr Gly Ile Gln Pro Asn Cys Pro Ala Val Pro 
            980                 985                 990         


Phe Ser Val Thr Val Pro Asp Met  Thr Glu Ser Pro Thr  Phe His Pro 
        995                 1000                 1005             


Leu Leu  Lys Ala Val Lys Ala  Gly Met Pro Ile Gly  Cys Tyr Leu 
    1010                 1015                 1020             


Ala Leu  Ser Met Thr Ala Val  Gly His Ser Ile Glu  Lys Phe Cys 
    1025                 1030                 1035             


Ala Glu  Gly Ile Pro Leu Leu  Gly Ile Leu Val Gln  Ser Arg His 
    1040                 1045                 1050             


Leu Arg  Thr Val Val His Val  Leu Asp Lys Ile Leu  Pro Leu Phe 
    1055                 1060                 1065             


Tyr Pro  Cys Gln Tyr Tyr Leu  Leu Lys Asn Glu Gln  Phe Leu Ser 
    1070                 1075                 1080             


His Leu  Leu Leu Phe Leu His  Leu Asp Ser Gly Val  Pro Gln Gly 
    1085                 1090                 1095             


Val Thr  Gln Gln Val Thr His  Lys Val Ala Gln His  Leu Thr Gly 
    1100                 1105                 1110             


Ala Ser  His Gly Asp Asn Val  Lys Leu Leu Asn Ser  Met Ile Gln 
    1115                 1120                 1125             


Ala His  Ile Ser Val Ser Thr  Gln Pro Asn Glu Val  Gly Pro Val 
    1130                 1135                 1140             


Ala Val  Leu Glu Phe Trp Val  Gln Ala Leu Ile Ser  Gln His Leu 
    1145                 1150                 1155             


Trp Tyr  Arg Glu Gln Pro Ile  Leu Phe Leu Met Asp  His Leu Cys 
    1160                 1165                 1170             


Lys Ala  Ala Phe Gln Leu Met  Gln Glu Asp Cys Ile  Gln Lys Leu 
    1175                 1180                 1185             


Leu Tyr  Gln Gln His Lys Asn  Ala Leu Gly Tyr His  Cys Asp Arg 
    1190                 1195                 1200             


Ser Leu  Leu Ser Ser Leu Val  Ser Trp Ile Val Ala  Gly Asn Ile 
    1205                 1210                 1215             


Thr Pro  Ser Phe Val Glu Gly  Leu Ala Thr Pro Thr  Gln Val Trp 
    1220                 1225                 1230             


Phe Ala  Trp Thr Val Leu Asn  Met Glu Ser Ile Phe  Glu Glu Asp 
    1235                 1240                 1245             


Ser Gln  Leu Arg Arg Val Ile  Glu Gly Glu Leu Val  Ile Asn Ser 
    1250                 1255                 1260             


Ala Phe  Thr Pro Asp Gln Ala  Leu Lys Lys Ala Gln  Thr Gln Leu 
    1265                 1270                 1275             


Lys Leu  Pro Ile Val Pro Ser  Leu Gln Arg Leu Leu  Ile Tyr Arg 
    1280                 1285                 1290             


Trp Ala  His Gln Ala Leu Val  Thr Pro Ser Asp His  Pro Leu Leu 
    1295                 1300                 1305             


Pro Leu  Ile Trp Gln Lys Phe  Phe Leu Leu Tyr Leu  His Arg Pro 
    1310                 1315                 1320             


Gly Pro  Gln Tyr Gly Leu Pro  Ile Asp Gly Cys Ile  Gly Arg Arg 
    1325                 1330                 1335             


Phe Phe  Gln Ser Pro Ala His  Ile Asn Leu Leu Lys  Glu Met Lys 
    1340                 1345                 1350             


Arg Arg  Leu Thr Glu Val Ala  Asp Phe His His Ala  Ala Ser Lys 
    1355                 1360                 1365             


Ala Leu  Arg Val Pro Ala Glu  Gly Ser Glu Gly Leu  Pro Glu Ser 
    1370                 1375                 1380             


His Ser  Gly Thr Pro Gly Tyr  Leu Thr Ser Pro Glu  Leu His Lys 
    1385                 1390                 1395             


Glu Leu  Val Arg Leu Phe Asn  Val Tyr Ile Leu Trp  Leu Glu Asp 
    1400                 1405                 1410             


Glu Asn  Phe Gln Lys Gly Asp  Thr Tyr Ile Pro Ser  Leu Pro Lys 
    1415                 1420                 1425             


His Tyr  Asp Ile His Arg Leu  Ala Lys Val Met Gln  Asn Gln Gln 
    1430                 1435                 1440             


Asp Leu  Trp Met Glu Tyr Leu  Asn Met Glu Arg Ile  Tyr His Glu 
    1445                 1450                 1455             


Phe Gln  Glu Thr Val Gly Leu  Trp Thr Gln Ala Lys  Leu Glu Ser 
    1460                 1465                 1470             


His Ser  Thr Pro Cys Ser Leu  Ser Val Gln Leu Asp  Phe Thr Asp 
    1475                 1480                 1485             


Pro Leu  Leu Ala Lys Glu Arg  Val Leu Ser Asn Leu  Arg Lys His 
    1490                 1495                 1500             


Glu Ala  Pro Gln Pro Pro Leu  Ala Leu His Pro Thr  Lys Pro Pro 
    1505                 1510                 1515             


Val Pro  Val Ile Ser Ser Ala  Val Leu Leu Ser Gln  Lys Asp Ala 
    1520                 1525                 1530             


Thr Gln  Leu Val Cys Thr Asp  Leu Asn Leu Leu Gln  Gln Gln Ala 
    1535                 1540                 1545             


Arg Thr  Ala Ala Leu Arg Glu  Ser Gln Gln Val Ala  Leu Asp Gly 
    1550                 1555                 1560             


Glu Leu  Leu Asp Thr Met Pro  Lys Gln Tyr Val Asn  Arg Glu Glu 
    1565                 1570                 1575             


Gln Thr  Thr Leu His Leu Glu  Cys Arg Gly Ser Ser  Gly Lys Lys 
    1580                 1585                 1590             


Cys Gln  Gly Ala Ala Val Val  Thr Val Gln Phe Glu  Gly Met His 
    1595                 1600                 1605             


Lys Asn  Glu Ala Ile Ser Gln  Gln Leu His Val Leu  Arg Lys Glu 
    1610                 1615                 1620             


Val Lys  Gln Leu Gln Ala Glu  Ala Ala Lys Pro Pro  Ser Leu Asn 
    1625                 1630                 1635             


Ile Val  Glu Ala Ala Val His  Ala Glu Asn Leu Ile  Thr Ala Leu 
    1640                 1645                 1650             


Val Asn  Ala Tyr Lys Leu Gln  Pro Thr Pro Gly Ile  Gln Lys Val 
    1655                 1660                 1665             


Gly Ile  Ser Leu Phe Phe Thr  Ile Val Asp Tyr Val  Ser Asp Glu 
    1670                 1675                 1680             


Thr Gln  Arg His Pro Pro Thr  Arg Gln Phe Phe Thr  Ser Cys Ile 
    1685                 1690                 1695             


Glu Ile  Leu Gly Gln Val Phe  Ile Ser Gly Ile Lys  Ser Glu Cys 
    1700                 1705                 1710             


Arg Lys  Val Leu Glu Thr Ile  Leu Lys Asn Ser Arg  Leu Cys Ser 
    1715                 1720                 1725             


Leu Leu  Ser Pro Phe Phe Thr  Pro Asn Ala Ala Pro  Ala Glu Phe 
    1730                 1735                 1740             


Ile Gln  Leu Tyr Glu Gln Val  Val Lys Phe Leu Ser  Glu Asp Asn 
    1745                 1750                 1755             


Ser Asp  Met Ile Phe Met Leu  Leu Thr Lys Phe Asp  Leu Lys Gln 
    1760                 1765                 1770             


Trp Leu  Ser Ala Thr Lys Pro  Pro Leu Ser Asp Arg  Thr Arg Leu 
    1775                 1780                 1785             


Leu Glu  Ser Ile His Leu Ala  Leu Thr Ala Trp Gly  Leu Glu Pro 
    1790                 1795                 1800             


Asp Glu  Asp Ile Leu Met Pro  Phe Asn Leu Phe Cys  Lys His Trp 
    1805                 1810                 1815             


Thr Tyr  Leu Leu Leu Tyr Gln  Phe Pro Asp Gln Tyr  Ser Asp Ile 
    1820                 1825                 1830             


Leu Arg  Leu Leu Met Gln Ser  Ser Ala Glu Gln Leu  Leu Ser Pro 
    1835                 1840                 1845             


Glu Cys  Trp Lys Ala Thr Leu  Arg Ala Leu Gly Cys  Cys Ala Pro 
    1850                 1855                 1860             


Ser Cys  Gln Gln Gly Ala Ala  Ser Thr Glu Gly Ala  Val Leu Pro 
    1865                 1870                 1875             


Ser Ser  Ser Asp Ala Leu Leu  Ser Asp Lys Gln Val  Met Glu Thr 
    1880                 1885                 1890             


Ile Gln  Trp Leu Ser Asp Phe  Phe Tyr Lys Leu Arg  Leu Ser Lys 
    1895                 1900                 1905             


Met Asp  Phe Lys Ser Phe Gly  Leu Phe Ser Lys Trp  Ser Pro Tyr 
    1910                 1915                 1920             


Met Ala  Asp Val Lys Thr Phe  Leu Gly Tyr Leu Val  Lys Arg Leu 
    1925                 1930                 1935             


Ile Asp  Leu Glu Met Thr Cys  Leu Ala Gln Asp Pro  Thr Ala Ser 
    1940                 1945                 1950             


Arg Lys  Thr Val Leu Lys Ser  Leu His Ser Val Ile  Ile Gln Leu 
    1955                 1960                 1965             


Phe Lys  Pro Trp Ile Leu Val  Leu Glu Asp Asn Glu  Ser Ser Gln 
    1970                 1975                 1980             


Gln Arg  His Tyr Pro Trp Leu  Glu Ser Asp Thr Val  Val Ala Ser 
    1985                 1990                 1995             


Ser Ile  Val Gln Leu Phe Thr  Asp Cys Ile Asp Ser  Leu His Glu 
    2000                 2005                 2010             


Ser Phe  Lys Asp Lys Leu Leu  Pro Gly Asp Ala Gly  Ala Leu Trp 
    2015                 2020                 2025             


Leu His  Leu Met His Tyr Cys  Glu Ala Cys Thr Ala  Pro Lys Met 
    2030                 2035                 2040             


Pro Glu  Phe Ile Leu Tyr Ala  Phe His Ser Thr Tyr  Arg Lys Leu 
    2045                 2050                 2055             


Pro Trp  Lys Asp Leu His Pro  Asp Gln Met Leu Met  Glu Ala Phe 
    2060                 2065                 2070             


Phe Lys  Val Glu Arg Gly Ser  Pro Lys Ser Cys Phe  Leu Phe Leu 
    2075                 2080                 2085             


Gly Ser  Val Leu Cys Glu Val  Asn Trp Val Ser Val  Leu Ser Asp 
    2090                 2095                 2100             


Ala Trp  Asn Ser Ser Pro His  Pro Glu Thr Arg Ser  Met Ile Val 
    2105                 2110                 2115             


Cys Leu  Leu Phe Met Met Ile  Leu Leu Ala Lys Glu  Val Gln Leu 
    2120                 2125                 2130             


Val Asp  Gln Thr Asp Ser Pro  Leu Leu Ser Leu Leu  Gly Gln Thr 
    2135                 2140                 2145             


Ser Ser  Leu Ser Trp His Leu  Val Asp Ile Val Ser  Tyr Gln Ser 
    2150                 2155                 2160             


Val Leu  Ser Tyr Phe Ser Ser  His Tyr Pro Pro Ser  Ile Ile Leu 
    2165                 2170                 2175             


Ala Lys  Glu Ser Tyr Ala Glu  Leu Ile Met Lys Leu  Leu Lys Val 
    2180                 2185                 2190             


Ser Ala  Gly Leu Ser Ile Pro  Thr Asp Ser Gln Lys  His Leu Asp 
    2195                 2200                 2205             


Ala Val  Pro Lys Cys Gln Ala  Phe Thr His Gln Met  Val Gln Phe 
    2210                 2215                 2220             


Leu Ser  Thr Leu Glu Gln Asn  Gly Lys Ile Thr Leu  Ala Val Leu 
    2225                 2230                 2235             


Glu Gln  Glu Met Ser Lys Leu  Leu Asp Asp Ile Ile  Val Phe Asn 
    2240                 2245                 2250             


Pro Pro  Asp Met Asp Ser Gln  Thr Arg His Met Ala  Leu Ser Ser 
    2255                 2260                 2265             


Leu Phe  Met Glu Val Leu Met  Met Met Asn Asn Ala  Thr Ile Pro 
    2270                 2275                 2280             


Thr Ala  Glu Phe Leu Arg Gly  Ser Ile Arg Thr Trp  Ile Gly Gln 
    2285                 2290                 2295             


Lys Met  His Gly Leu Val Val  Leu Pro Leu Leu Thr  Ala Ala Cys 
    2300                 2305                 2310             


Gln Ser  Leu Ala Ser Val Arg  His Met Ala Glu Thr  Thr Glu Ala 
    2315                 2320                 2325             


Cys Ile  Thr Ala Tyr Phe Lys  Glu Ser Pro Leu Asn  Gln Asn Ser 
    2330                 2335                 2340             


Gly Trp  Gly Pro Ile Leu Val  Ser Leu Gln Val Pro  Glu Leu Thr 
    2345                 2350                 2355             


Met Glu  Glu Phe Leu Gln Glu  Cys Leu Thr Leu Gly  Ser Tyr Leu 
    2360                 2365                 2370             


Thr Leu  Tyr Val Tyr Leu Leu  Gln Cys Leu Asn Ser  Glu Gln Thr 
    2375                 2380                 2385             


Leu Arg  Asn Glu Met Lys Val  Leu Leu Ile Leu Ser  Lys Trp Leu 
    2390                 2395                 2400             


Glu Gln  Val Tyr Pro Ser Ser  Val Glu Glu Glu Ala  Lys Leu Phe 
    2405                 2410                 2415             


Leu Trp  Trp His Gln Val Leu  Gln Leu Ser Leu Ile  Gln Thr Glu 
    2420                 2425                 2430             


Gln Asn  Asp Ser Val Leu Thr  Glu Ser Val Ile Arg  Ile Leu Leu 
    2435                 2440                 2445             


Leu Val  Gln Ser Arg Gln Asn  Leu Val Ala Glu Glu  Arg Leu Ser 
    2450                 2455                 2460             


Ser Gly  Ile Leu Gly Ala Ile  Gly Phe Gly Arg Lys  Ser Pro Leu 
    2465                 2470                 2475             


Ser Asn  Arg Phe Arg Val Val  Ala Arg Ser Met Ala  Ala Phe Leu 
    2480                 2485                 2490             


Ser Val  Gln Val Pro Met Glu  Asp Gln Ile Arg Leu  Arg Pro Gly 
    2495                 2500                 2505             


Ser Glu  Leu His Leu Thr Pro  Lys Ala Gln Gln Ala  Leu Asn Ala 
    2510                 2515                 2520             


Leu Glu  Ser Met Ala Ser Ser  Lys Gln Tyr Val Glu  Tyr Gln Asp 
    2525                 2530                 2535             


Gln Ile  Leu Gln Ala Thr Gln  Phe Ile Arg His Pro  Gly His Cys 
    2540                 2545                 2550             


Leu Gln  Asp Gly Lys Ser Phe  Leu Ala Leu Leu Val  Asn Cys Leu 
    2555                 2560                 2565             


Tyr Pro  Glu Val His Tyr Leu  Asp His Ile Arg 
    2570                 2575                 


<210>  103
<211>  821
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Asp Pro Glu Cys Ala Gln Leu Leu Pro Ala Leu Cys Ala Val Leu 
1               5                   10                  15      


Val Asp Pro Arg Gln Pro Val Ala Asp Asp Thr Cys Leu Glu Lys Leu 
            20                  25                  30          


Leu Asp Trp Phe Lys Thr Val Thr Glu Gly Glu Ser Ser Val Val Leu 
        35                  40                  45              


Leu Gln Glu His Pro Cys Leu Val Glu Leu Leu Ser His Val Leu Lys 
    50                  55                  60                  


Val Gln Asp Leu Ser Ser Gly Val Leu Ser Phe Ser Leu Arg Leu Ala 
65                  70                  75                  80  


Gly Thr Phe Ala Ala Gln Glu Asn Cys Phe Gln Tyr Leu Gln Gln Gly 
                85                  90                  95      


Glu Leu Leu Pro Gly Leu Phe Gly Glu Pro Gly Pro Leu Gly Arg Ala 
            100                 105                 110         


Thr Trp Ala Val Pro Thr Val Arg Ser Gly Trp Ile Gln Gly Leu Arg 
        115                 120                 125             


Ser Leu Ala Gln His Pro Ser Ala Leu Arg Phe Leu Ala Asp His Gly 
    130                 135                 140                 


Ala Val Asp Thr Ile Phe Ser Leu Gln Gly Asp Ser Ser Leu Phe Val 
145                 150                 155                 160 


Ala Ser Ala Ala Ser Gln Leu Leu Val His Val Leu Ala Leu Ser Met 
                165                 170                 175     


Arg Gly Gly Ala Glu Gly Gln Pro Cys Leu Pro Gly Gly Asp Trp Pro 
            180                 185                 190         


Ala Cys Ala Gln Lys Ile Met Asp His Val Glu Glu Ser Leu Cys Ser 
        195                 200                 205             


Ala Ala Thr Pro Lys Val Thr Gln Ala Leu Asn Val Leu Thr Thr Thr 
    210                 215                 220                 


Phe Gly Arg Cys Gln Ser Pro Trp Thr Glu Ala Leu Trp Val Arg Leu 
225                 230                 235                 240 


Ser Pro Arg Val Ala Cys Leu Leu Glu Arg Asp Pro Ile Pro Ala Ala 
                245                 250                 255     


His Ser Phe Val Asp Leu Leu Leu Cys Val Ala Arg Ser Pro Val Phe 
            260                 265                 270         


Ser Ser Ser Asp Gly Ser Leu Trp Glu Thr Val Ala Arg Ala Leu Ser 
        275                 280                 285             


Cys Leu Gly Pro Thr His Met Gly Pro Leu Ala Leu Gly Ile Leu Lys 
    290                 295                 300                 


Leu Glu His Cys Pro Gln Ala Leu Arg Thr Gln Ala Phe Gln Val Leu 
305                 310                 315                 320 


Leu Gln Pro Leu Ala Cys Val Leu Lys Ala Thr Val Gln Ala Pro Gly 
                325                 330                 335     


Pro Pro Gly Leu Leu Asp Gly Thr Ala Asp Asp Ala Thr Thr Val Asp 
            340                 345                 350         


Thr Leu Leu Ala Ser Lys Ser Ser Cys Ala Gly Leu Leu Cys Arg Thr 
        355                 360                 365             


Leu Ala His Leu Glu Glu Leu Gln Pro Leu Pro Gln Arg Pro Ser Pro 
    370                 375                 380                 


Trp Pro Gln Ala Ser Leu Leu Gly Ala Thr Val Thr Val Leu Arg Leu 
385                 390                 395                 400 


Cys Asp Gly Ser Ala Ala Pro Ala Ser Ser Val Gly Gly His Leu Cys 
                405                 410                 415     


Gly Thr Leu Ala Gly Cys Val Arg Val Gln Arg Ala Ala Leu Asp Phe 
            420                 425                 430         


Leu Gly Thr Leu Ser Gln Gly Thr Gly Pro Gln Glu Leu Val Thr Gln 
        435                 440                 445             


Ala Leu Ala Val Leu Leu Glu Cys Leu Glu Ser Pro Gly Ser Ser Pro 
    450                 455                 460                 


Thr Val Leu Lys Lys Ala Phe Gln Ala Thr Leu Arg Trp Leu Leu Ser 
465                 470                 475                 480 


Ser Pro Lys Thr Pro Gly Cys Ser Asp Leu Gly Pro Leu Ile Pro Gln 
                485                 490                 495     


Phe Leu Arg Glu Leu Phe Pro Val Leu Gln Lys Arg Leu Cys His Pro 
            500                 505                 510         


Cys Trp Glu Val Arg Asp Ser Ala Leu Glu Phe Leu Thr Gln Leu Ser 
        515                 520                 525             


Arg His Trp Gly Gly Gln Ala Asp Phe Arg Cys Ala Leu Leu Ala Ser 
    530                 535                 540                 


Glu Val Pro Gln Leu Ala Leu Gln Leu Leu Gln Asp Pro Glu Ser Tyr 
545                 550                 555                 560 


Val Arg Ala Ser Ala Val Thr Ala Met Gly Gln Leu Ser Ser Gln Gly 
                565                 570                 575     


Leu His Ala Pro Thr Ser Pro Glu His Ala Glu Ala Arg Gln Ser Leu 
            580                 585                 590         


Phe Leu Glu Leu Leu His Ile Leu Ser Val Asp Ser Glu Gly Phe Pro 
        595                 600                 605             


Arg Arg Ala Val Met Gln Val Phe Thr Glu Trp Leu Arg Asp Gly His 
    610                 615                 620                 


Ala Asp Ala Ala Gln Asp Thr Glu Gln Phe Val Ala Thr Val Leu Gln 
625                 630                 635                 640 


Ala Ala Ser Arg Asp Leu Asp Trp Glu Val Arg Ala Gln Gly Leu Glu 
                645                 650                 655     


Leu Ala Leu Val Phe Leu Gly Gln Thr Leu Gly Pro Pro Arg Thr His 
            660                 665                 670         


Cys Pro Tyr Ala Val Ala Leu Pro Glu Val Ala Pro Ala Gln Pro Leu 
        675                 680                 685             


Thr Glu Ala Leu Arg Ala Leu Cys His Val Gly Leu Phe Asp Phe Ala 
    690                 695                 700                 


Phe Cys Ala Leu Phe Asp Cys Asp Arg Pro Val Ala Gln Lys Ser Cys 
705                 710                 715                 720 


Asp Leu Leu Leu Phe Leu Arg Asp Lys Ile Ala Ser Tyr Ser Ser Leu 
                725                 730                 735     


Arg Glu Ala Arg Gly Ser Pro Asn Thr Ala Ser Ala Glu Ala Thr Leu 
            740                 745                 750         


Pro Arg Trp Arg Ala Gly Glu Gln Ala Gln Pro Pro Gly Asp Gln Glu 
        755                 760                 765             


Pro Glu Ala Val Leu Ala Met Leu Arg Ser Leu Asp Leu Glu Gly Leu 
    770                 775                 780                 


Arg Ser Thr Leu Ala Glu Ser Ser Asp His Val Glu Lys Ser Pro Gln 
785                 790                 795                 800 


Ser Leu Leu Gln Asp Met Leu Ala Thr Gly Gly Phe Leu Gln Gly Asp 
                805                 810                 815     


Glu Ala Asp Cys Tyr 
            820     


<210>  104
<211>  951
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Cys Cys Thr Glu Gly Ser Leu Arg Lys Arg Asp Ser Gln Arg Ala 
1               5                   10                  15      


Pro Glu Ala Val Leu Cys Leu Gln Leu Trp Gln Arg Thr Val Pro Leu 
            20                  25                  30          


Asp Thr Leu Lys Gly Leu Gly Thr Cys Phe Pro Ser Gly Pro Glu Leu 
        35                  40                  45              


Arg Gly Ala Gly Ile Ala Ala Ala Met Glu Arg Ala Ser Glu Arg Arg 
    50                  55                  60                  


Thr Ala Ser Ala Leu Phe Ala Gly Phe Arg Ala Leu Gly Leu Phe Ser 
65                  70                  75                  80  


Asn Asp Ile Pro His Val Val Arg Phe Ser Ala Leu Lys Arg Arg Phe 
                85                  90                  95      


Tyr Val Thr Thr Cys Val Gly Lys Ser Phe His Thr Tyr Asp Val Gln 
            100                 105                 110         


Lys Leu Ser Leu Val Ala Val Ser Asn Ser Val Pro Gln Asp Ile Cys 
        115                 120                 125             


Cys Met Ala Ala Asp Gly Arg Leu Val Phe Ala Ala Tyr Gly Asn Val 
    130                 135                 140                 


Phe Ser Ala Phe Ala Arg Asn Lys Glu Ile Val His Thr Phe Lys Gly 
145                 150                 155                 160 


His Lys Ala Glu Ile His Phe Leu Gln Pro Phe Gly Asp His Ile Ile 
                165                 170                 175     


Ser Val Asp Thr Asp Gly Ile Leu Ile Ile Trp His Ile Tyr Ser Glu 
            180                 185                 190         


Glu Glu Tyr Leu Gln Leu Thr Phe Asp Lys Ser Val Phe Lys Ile Ser 
        195                 200                 205             


Ala Ile Leu His Pro Ser Thr Tyr Leu Asn Lys Ile Leu Leu Gly Ser 
    210                 215                 220                 


Glu Gln Gly Ser Leu Gln Leu Trp Asn Val Lys Ser Asn Lys Leu Leu 
225                 230                 235                 240 


Tyr Thr Phe Pro Gly Trp Lys Val Gly Val Thr Ala Leu Gln Gln Ala 
                245                 250                 255     


Pro Ala Val Asp Val Val Ala Ile Gly Leu Met Ser Gly Gln Val Ile 
            260                 265                 270         


Ile His Asn Ile Lys Phe Asn Glu Thr Leu Met Lys Phe Arg Gln Asp 
        275                 280                 285             


Trp Gly Pro Ile Thr Ser Ile Ser Phe Arg Thr Asp Gly His Pro Val 
    290                 295                 300                 


Met Ala Ala Gly Ser Pro Cys Gly His Ile Gly Leu Trp Asp Leu Glu 
305                 310                 315                 320 


Asp Lys Lys Leu Ile Asn Gln Met Arg Asn Ala His Ser Thr Ala Ile 
                325                 330                 335     


Ala Gly Leu Thr Phe Leu His Arg Glu Pro Leu Leu Val Thr Asn Gly 
            340                 345                 350         


Ala Asp Asn Ala Leu Arg Ile Trp Ile Phe Asp Gly Pro Thr Gly Glu 
        355                 360                 365             


Gly Arg Leu Leu Arg Phe Arg Met Gly His Ser Ala Pro Leu Thr Asn 
    370                 375                 380                 


Ile Arg Tyr Tyr Gly Gln Asn Gly Gln Gln Ile Leu Ser Ala Ser Gln 
385                 390                 395                 400 


Asp Gly Thr Leu Gln Ser Phe Ser Thr Val His Glu Lys Phe Asn Lys 
                405                 410                 415     


Ser Leu Gly His Gly Leu Ile Asn Lys Lys Arg Val Lys Arg Lys Gly 
            420                 425                 430         


Leu Gln Asn Thr Met Ser Val Arg Leu Pro Pro Ile Thr Lys Phe Ala 
        435                 440                 445             


Ala Glu Glu Ala Arg Glu Ser Asp Trp Asp Gly Ile Ile Ala Cys His 
    450                 455                 460                 


Gln Gly Lys Leu Ser Cys Ser Thr Trp Asn Tyr Gln Lys Ser Thr Ile 
465                 470                 475                 480 


Gly Ala Tyr Phe Leu Lys Pro Lys Glu Leu Lys Lys Asp Asp Ile Thr 
                485                 490                 495     


Ala Thr Ala Val Asp Ile Thr Ser Cys Gly Asn Phe Ala Val Ile Gly 
            500                 505                 510         


Leu Ser Ser Gly Thr Val Asp Val Tyr Asn Met Gln Ser Gly Ile His 
        515                 520                 525             


Arg Gly Ser Phe Gly Lys Asp Gln Ala His Lys Gly Ser Val Arg Gly 
    530                 535                 540                 


Val Ala Val Asp Gly Leu Asn Gln Leu Thr Val Thr Thr Gly Ser Glu 
545                 550                 555                 560 


Gly Leu Leu Lys Phe Trp Asn Phe Lys Asn Lys Ile Leu Ile His Ser 
                565                 570                 575     


Val Ser Leu Ser Ser Ser Pro Asn Ile Met Leu Leu His Arg Asp Ser 
            580                 585                 590         


Gly Ile Leu Gly Leu Ala Leu Asp Asp Phe Ser Ile Ser Val Leu Asp 
        595                 600                 605             


Ile Glu Thr Arg Lys Ile Val Arg Glu Phe Ser Gly His Gln Gly Gln 
    610                 615                 620                 


Ile Asn Asp Met Ala Phe Ser Pro Asp Gly Arg Trp Leu Ile Ser Ala 
625                 630                 635                 640 


Ala Met Asp Cys Ser Ile Arg Thr Trp Asp Leu Pro Ser Gly Cys Leu 
                645                 650                 655     


Ile Asp Cys Phe Leu Leu Asp Ser Ala Pro Leu Asn Val Ser Met Ser 
            660                 665                 670         


Pro Thr Gly Asp Phe Leu Ala Thr Ser His Val Asp His Leu Gly Ile 
        675                 680                 685             


Tyr Leu Trp Ser Asn Ile Ser Leu Tyr Ser Val Val Ser Leu Arg Pro 
    690                 695                 700                 


Leu Pro Ala Asp Tyr Val Pro Ser Ile Val Met Leu Pro Gly Thr Cys 
705                 710                 715                 720 


Gln Thr Gln Asp Val Glu Val Ser Glu Glu Thr Val Glu Pro Ser Asp 
                725                 730                 735     


Glu Leu Ile Glu Tyr Asp Ser Pro Glu Gln Leu Asn Glu Gln Leu Val 
            740                 745                 750         


Thr Leu Ser Leu Leu Pro Glu Ser Arg Trp Lys Asn Leu Leu Asn Leu 
        755                 760                 765             


Asp Val Ile Lys Lys Lys Asn Lys Pro Lys Glu Pro Pro Lys Val Pro 
    770                 775                 780                 


Lys Ser Ala Pro Phe Phe Ile Pro Thr Ile Pro Gly Leu Val Pro Arg 
785                 790                 795                 800 


Tyr Ala Ala Pro Glu Gln Asn Asn Asp Pro Gln Gln Ser Lys Val Val 
                805                 810                 815     


Asn Leu Gly Val Leu Ala Gln Lys Ser Asp Phe Cys Leu Lys Leu Glu 
            820                 825                 830         


Glu Gly Leu Val Asn Asn Lys Tyr Asp Thr Ala Leu Asn Leu Leu Lys 
        835                 840                 845             


Glu Ser Gly Pro Ser Gly Ile Glu Thr Glu Leu Arg Ser Leu Ser Pro 
    850                 855                 860                 


Asp Cys Gly Gly Ser Ile Glu Val Met Gln Ser Phe Leu Lys Met Ile 
865                 870                 875                 880 


Gly Met Met Leu Asp Arg Lys Arg Asp Phe Glu Leu Ala Gln Ala Tyr 
                885                 890                 895     


Leu Ala Leu Phe Leu Lys Leu His Leu Lys Met Leu Pro Ser Glu Pro 
            900                 905                 910         


Val Leu Leu Glu Glu Ile Thr Asn Leu Ser Ser Gln Val Glu Glu Asn 
        915                 920                 925             


Trp Thr His Leu Gln Ser Leu Phe Asn Gln Ser Met Cys Ile Leu Asn 
    930                 935                 940                 


Tyr Leu Lys Ser Ala Leu Leu 
945                 950     


<210>  105
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Ala Ala Gln Arg Ile Arg Ala Ala Asn Ser Asn Gly Leu Pro Arg 
1               5                   10                  15      


Cys Lys Ser Glu Gly Thr Leu Ile Asp Leu Ser Glu Gly Phe Ser Glu 
            20                  25                  30          


Thr Ser Phe Asn Asp Ile Lys Val Pro Ser Pro Ser Ala Leu Leu Val 
        35                  40                  45              


Asp Asn Pro Thr Pro Phe Gly Asn Ala Lys Glu Val Ile Ala Ile Lys 
    50                  55                  60                  


Asp Tyr Cys Pro Thr Asn Phe Thr Thr Leu Lys Phe Ser Lys Gly Asp 
65                  70                  75                  80  


His Leu Tyr Val Leu Asp Thr Ser Gly Gly Glu Trp Trp Tyr Ala His 
                85                  90                  95      


Asn Thr Thr Glu Met Gly Tyr Ile Pro Ser Ser Tyr Val Gln Pro Leu 
            100                 105                 110         


Asn Tyr Arg Asn Ser Thr Leu Ser Asp Ser Gly Met Ile Asp Asn Leu 
        115                 120                 125             


Pro Asp Ser Pro Asp Glu Val Ala Lys Glu Leu Glu Leu Leu Gly Gly 
    130                 135                 140                 


Trp Thr Asp Asp Lys Lys Val Pro Gly Arg Met Tyr Ser Asn Asn Pro 
145                 150                 155                 160 


Phe Trp Asn Gly Val Gln Thr Asn Pro Phe Leu Asn Gly Asn Val Pro 
                165                 170                 175     


Val Met Pro Ser Leu Asp Glu Leu Asn Pro Lys Ser Thr Val Asp Leu 
            180                 185                 190         


Leu Leu Phe Asp Ala Gly Thr Ser Ser Phe Thr Glu Ser Ser Ser Ala 
        195                 200                 205             


Thr Thr Asn Ser Thr Gly Asn Ile Phe Asp Glu Leu Pro Val Thr Asn 
    210                 215                 220                 


Gly Leu His Ala Glu Pro Pro Val Arg Arg Asp Asn Pro Phe Phe Arg 
225                 230                 235                 240 


Ser Lys Arg Ser Tyr Ser Leu Ser Glu Leu Ser Val Leu Gln Ala Lys 
                245                 250                 255     


Ser Asp Ala Pro Thr Ser Ser Ser Phe Phe Thr Gly Leu Lys Ser Pro 
            260                 265                 270         


Ala Pro Glu Gln Phe Gln Ser Arg Glu Asp Phe Arg Thr Ala Trp Leu 
        275                 280                 285             


Asn His Arg Lys Leu Ala Arg Ser Cys His Asp Leu Asp Leu Leu Gly 
    290                 295                 300                 


Gln Ser Pro Gly Trp Gly Gln Thr Gln Ala Val Glu Thr Asn Ile Val 
305                 310                 315                 320 


Cys Lys Leu Asp Ser Ser Gly Gly Ala Val Gln Leu Pro Asp Thr Ser 
                325                 330                 335     


Ile Ser Ile His Val Pro Glu Gly His Val Ala Pro Gly Glu Thr Gln 
            340                 345                 350         


Gln Ile Ser Met Lys Ala Leu Leu Asp Pro Pro Leu Glu Leu Asn Ser 
        355                 360                 365             


Asp Arg Ser Cys Ser Ile Ser Pro Val Leu Glu Val Lys Leu Ser Asn 
    370                 375                 380                 


Leu Glu Val Lys Thr Ser Ile Ile Leu Glu Met Lys Val Ser Ala Glu 
385                 390                 395                 400 


Ile Lys Asn Asp Leu Phe Ser Lys Ser Thr Val Gly Leu Gln Cys Leu 
                405                 410                 415     


Arg Ser Asp Ser Lys Glu Gly Pro Tyr Val Ser Val Pro Leu Asn Cys 
            420                 425                 430         


Ser Cys Gly Asp Thr Val Gln Ala Gln Leu His Asn Leu Glu Pro Cys 
        435                 440                 445             


Met Tyr Val Ala Val Val Ala His Gly Pro Ser Ile Leu Tyr Pro Ser 
    450                 455                 460                 


Thr Val Trp Asp Phe Ile Asn Lys Lys Val Thr Val Gly Leu Tyr Gly 
465                 470                 475                 480 


Pro Lys His Ile His Pro Ser Phe Lys Thr Val Val Thr Ile Phe Gly 
                485                 490                 495     


His Asp Cys Ala Pro Lys Thr Leu Leu Val Ser Glu Val Thr Arg Gln 
            500                 505                 510         


Ala Pro Asn Pro Ala Pro Val Ala Leu Gln Leu Trp Gly Lys His Gln 
        515                 520                 525             


Phe Val Leu Ser Arg Pro Gln Asp Leu Lys Val Cys Met Phe Ser Asn 
    530                 535                 540                 


Met Thr Asn Tyr Glu Val Lys Ala Ser Glu Gln Ala Lys Val Val Arg 
545                 550                 555                 560 


Gly Phe Gln Leu Lys Leu Gly Lys Val Ser Arg Leu Ile Phe Pro Ile 
                565                 570                 575     


Thr Ser Gln Asn Pro Asn Glu Leu Ser Asp Phe Thr Leu Arg Val Gln 
            580                 585                 590         


Val Lys Asp Asp Gln Glu Ala Ile Leu Thr Gln Phe Cys Val Gln Thr 
        595                 600                 605             


Pro Gln Pro Pro Pro Lys Ser Ala Ile Lys Pro Ser Gly Gln Arg Arg 
    610                 615                 620                 


Phe Leu Lys Lys Asn Glu Val Gly Lys Ile Ile Leu Ser Pro Phe Ala 
625                 630                 635                 640 


Thr Thr Thr Lys Tyr Pro Thr Phe Gln Asp Arg Pro Val Ser Ser Leu 
                645                 650                 655     


Lys Phe Gly Lys Leu Leu Lys Thr Val Val Arg Gln Asn Lys Asn His 
            660                 665                 670         


Tyr Leu Leu Glu Tyr Lys Lys Gly Asp Gly Ile Ala Leu Leu Ser Glu 
        675                 680                 685             


Glu Arg Val Arg Leu Arg Gly Gln Leu Trp Thr Lys Glu Trp Tyr Ile 
    690                 695                 700                 


Gly Tyr Tyr Gln Gly Arg Val Gly Leu Val His Thr Lys Asn Val Leu 
705                 710                 715                 720 


Val Val Gly Arg Ala Arg Pro Ser Leu Cys Ser Gly Pro Glu Leu Ser 
                725                 730                 735     


Thr Ser Val Leu Leu Glu Gln Ile Leu Arg Pro Cys Lys Phe Leu Thr 
            740                 745                 750         


Tyr Ile Tyr Ala Ser Val Arg Thr Leu Leu Met Glu Asn Ile Ser Ser 
        755                 760                 765             


Trp Arg Ser Phe Ala Asp Ala Leu Gly Tyr Val Asn Leu Pro Leu Thr 
    770                 775                 780                 


Phe Phe Cys Arg Ala Glu Leu Asp Ser Glu Pro Glu Arg Val Ala Ser 
785                 790                 795                 800 


Val Leu Glu Lys Leu Lys Glu Asp Cys Asn Asn Thr Glu Asn Lys Glu 
                805                 810                 815     


Arg Lys Ser Phe Gln Lys Glu Leu Val Met Ala Leu Leu Lys Met Asp 
            820                 825                 830         


Cys Gln Gly Leu Val Val Arg Leu Ile Gln Asp Phe Val Leu Leu Thr 
        835                 840                 845             


Thr Ala Val Glu Val Ala Gln Arg Trp Arg Glu Leu Ala Glu Lys Leu 
    850                 855                 860                 


Ala Lys Val Ser Lys Gln Gln Met Asp Ala Tyr Glu Ser Pro His Arg 
865                 870                 875                 880 


Asp Arg Asn Gly Val Val Asp Ser Glu Ala Met Trp Lys Pro Ala Tyr 
                885                 890                 895     


Asp Phe Leu Leu Thr Trp Ser His Gln Ile Gly Asp Ser Tyr Arg Asp 
            900                 905                 910         


Val Ile Gln Glu Leu His Leu Gly Leu Asp Lys Met Lys Asn Pro Ile 
        915                 920                 925             


Thr Lys Arg Trp Lys His Leu Thr Gly Thr Leu Ile Leu Val Asn Ser 
    930                 935                 940                 


Leu Asp Val Leu Arg Ala Ala Ala Phe Ser Pro Ala Asp Gln Asp Asp 
945                 950                 955                 960 


Phe Val Ile 
            


<210>  106
<211>  1523
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Thr Ser Val Trp Lys Arg Leu Gln Arg Val Gly Lys Arg Ala Ala 
1               5                   10                  15      


Lys Phe Gln Phe Val Ala Cys Tyr His Glu Leu Val Leu Glu Cys Thr 
            20                  25                  30          


Lys Lys Trp Gln Pro Asp Lys Leu Val Val Val Trp Thr Arg Arg Asn 
        35                  40                  45              


Arg Arg Ile Cys Ser Lys Ala His Ser Trp Gln Pro Gly Ile Gln Asn 
    50                  55                  60                  


Pro Tyr Arg Gly Thr Val Val Trp Met Val Pro Glu Asn Val Asp Ile 
65                  70                  75                  80  


Ser Val Thr Leu Tyr Arg Asp Pro His Val Asp Gln Tyr Glu Ala Lys 
                85                  90                  95      


Glu Trp Thr Phe Ile Ile Glu Asn Glu Ser Lys Gly Gln Arg Lys Val 
            100                 105                 110         


Leu Ala Thr Ala Glu Val Asp Leu Ala Arg His Ala Gly Pro Val Pro 
        115                 120                 125             


Val Gln Val Pro Val Arg Leu Arg Leu Lys Pro Lys Ser Val Lys Val 
    130                 135                 140                 


Val Gln Ala Glu Leu Ser Leu Thr Leu Ser Gly Val Leu Leu Arg Glu 
145                 150                 155                 160 


Gly Arg Ala Thr Asp Asp Asp Met Gln Ser Leu Ala Ser Leu Met Ser 
                165                 170                 175     


Val Lys Pro Ser Asp Val Gly Asn Leu Asp Asp Phe Ala Glu Ser Asp 
            180                 185                 190         


Glu Asp Glu Ala His Gly Pro Gly Ala Pro Glu Ala Arg Ala Arg Val 
        195                 200                 205             


Pro Gln Pro Asp Pro Ser Arg Glu Leu Lys Thr Leu Cys Glu Glu Glu 
    210                 215                 220                 


Glu Glu Gly Gln Gly Arg Pro Gln Gln Ala Val Ala Ser Pro Ser Asn 
225                 230                 235                 240 


Ala Glu Asp Thr Ser Pro Ala Pro Val Ser Ala Pro Ala Pro Pro Ala 
                245                 250                 255     


Arg Thr Ser Arg Gly Gln Gly Ser Glu Arg Ala Asn Glu Ala Gly Gly 
            260                 265                 270         


Gln Val Gly Pro Glu Ala Pro Arg Pro Pro Glu Thr Ser Pro Glu Met 
        275                 280                 285             


Arg Ser Ser Arg Gln Pro Ala Gln Asp Thr Ala Pro Thr Pro Ala Pro 
    290                 295                 300                 


Arg Leu Arg Lys Gly Ser Asp Ala Leu Arg Pro Pro Val Pro Gln Gly 
305                 310                 315                 320 


Glu Asp Glu Val Pro Lys Ala Ser Gly Ala Pro Pro Ala Gly Leu Gly 
                325                 330                 335     


Ser Ala Arg Glu Thr Gln Ala Gln Ala Cys Pro Gln Glu Gly Thr Glu 
            340                 345                 350         


Ala His Gly Ala Arg Leu Gly Pro Ser Ile Glu Asp Lys Gly Ser Gly 
        355                 360                 365             


Asp Pro Phe Gly Arg Gln Arg Leu Lys Ala Glu Glu Met Asp Thr Glu 
    370                 375                 380                 


Asp Arg Pro Glu Ala Ser Gly Val Asp Thr Glu Pro Arg Ser Gly Gly 
385                 390                 395                 400 


Arg Glu Ala Asn Thr Lys Arg Ser Gly Val Arg Ala Gly Glu Ala Glu 
                405                 410                 415     


Glu Ser Ser Ala Val Cys Gln Val Asp Ala Glu Gln Arg Ser Lys Val 
            420                 425                 430         


Arg His Val Asp Thr Lys Gly Pro Glu Ala Thr Gly Val Met Pro Glu 
        435                 440                 445             


Ala Arg Cys Arg Gly Thr Pro Glu Ala Pro Pro Arg Gly Ser Gln Gly 
    450                 455                 460                 


Arg Leu Gly Val Arg Thr Arg Asp Glu Ala Pro Ser Gly Leu Ser Leu 
465                 470                 475                 480 


Pro Pro Ala Glu Pro Ala Gly His Ser Gly Gln Leu Gly Asp Leu Glu 
                485                 490                 495     


Gly Ala Arg Ala Ala Ala Gly Gln Glu Arg Glu Gly Ala Glu Val Arg 
            500                 505                 510         


Gly Gly Ala Pro Gly Ile Glu Gly Thr Gly Leu Glu Gln Gly Pro Ser 
        515                 520                 525             


Val Gly Ala Ile Ser Thr Arg Pro Gln Val Ser Ser Trp Gln Gly Ala 
    530                 535                 540                 


Leu Leu Ser Thr Ala Gln Gly Ala Ile Ser Arg Gly Leu Gly Gly Trp 
545                 550                 555                 560 


Glu Ala Glu Ala Gly Gly Ser Gly Asp Leu Glu Thr Glu Thr Glu Val 
                565                 570                 575     


Val Gly Leu Glu Val Leu Gly Thr Gln Glu Lys Glu Val Glu Gly Ser 
            580                 585                 590         


Gly Phe Pro Glu Thr Arg Thr Leu Glu Ile Glu Ile Leu Gly Ala Leu 
        595                 600                 605             


Glu Lys Glu Ala Ala Arg Ser Arg Val Leu Glu Ser Glu Val Ala Gly 
    610                 615                 620                 


Thr Ala Gln Cys Glu Gly Leu Glu Thr Gln Glu Thr Glu Val Gly Val 
625                 630                 635                 640 


Ile Glu Thr Pro Gly Thr Glu Thr Glu Val Leu Gly Thr Gln Lys Thr 
                645                 650                 655     


Glu Ala Gly Gly Ser Gly Val Leu Gln Thr Arg Thr Thr Ile Ala Glu 
            660                 665                 670         


Thr Glu Val Leu Val Thr Gln Glu Ile Ser Gly Asp Leu Gly Pro Leu 
        675                 680                 685             


Lys Ile Glu Asp Thr Ile Gln Ser Glu Met Leu Gly Thr Gln Glu Thr 
    690                 695                 700                 


Glu Val Glu Ala Ser Arg Val Pro Glu Ser Glu Ala Glu Gly Thr Glu 
705                 710                 715                 720 


Ala Lys Ile Leu Gly Thr Gln Glu Ile Thr Ala Arg Asp Ser Gly Val 
                725                 730                 735     


Arg Glu Ile Glu Ala Glu Ile Ala Glu Ser Asp Ile Leu Val Ala Gln 
            740                 745                 750         


Glu Ile Glu Val Gly Leu Leu Gly Val Leu Gly Ile Glu Thr Gly Ala 
        755                 760                 765             


Ala Glu Gly Ala Ile Leu Gly Thr Gln Glu Ile Ala Ser Arg Asp Ser 
    770                 775                 780                 


Gly Val Pro Gly Leu Glu Ala Asp Thr Thr Gly Ile Gln Val Lys Glu 
785                 790                 795                 800 


Val Gly Gly Ser Glu Val Pro Glu Ile Ala Thr Gly Thr Ala Glu Thr 
                805                 810                 815     


Glu Ile Leu Gly Thr Gln Glu Ile Ala Ser Arg Ser Ser Gly Val Pro 
            820                 825                 830         


Gly Leu Glu Ser Glu Val Ala Gly Ala Gln Glu Thr Glu Val Gly Gly 
        835                 840                 845             


Ser Gly Ile Ser Gly Pro Glu Ala Gly Met Ala Glu Ala Arg Val Leu 
    850                 855                 860                 


Met Thr Arg Lys Thr Glu Ile Ile Val Pro Glu Ala Glu Lys Glu Glu 
865                 870                 875                 880 


Ala Gln Thr Ser Gly Val Gln Glu Ala Glu Thr Arg Val Gly Ser Ala 
                885                 890                 895     


Leu Lys Tyr Glu Ala Leu Arg Ala Pro Val Thr Gln Pro Arg Val Leu 
            900                 905                 910         


Gly Ser Gln Glu Ala Lys Ala Glu Ile Ser Gly Val Gln Gly Ser Glu 
        915                 920                 925             


Thr Gln Val Leu Arg Val Gln Glu Ala Glu Ala Gly Val Trp Gly Met 
    930                 935                 940                 


Ser Glu Gly Lys Ser Gly Ala Trp Gly Ala Gln Glu Ala Glu Met Lys 
945                 950                 955                 960 


Val Leu Glu Ser Pro Glu Asn Lys Ser Gly Thr Phe Lys Ala Gln Glu 
                965                 970                 975     


Ala Glu Ala Gly Val Leu Gly Asn Glu Lys Gly Lys Glu Ala Glu Gly 
            980                 985                 990         


Ser Leu Thr Glu Ala Ser Leu Pro  Glu Ala Gln Val Ala  Ser Gly Ala 
        995                 1000                 1005             


Gly Ala  Gly Ala Pro Arg Ala  Ser Ser Pro Glu Lys  Ala Glu Glu 
    1010                 1015                 1020             


Asp Arg  Arg Leu Pro Gly Ser  Gln Ala Pro Pro Ala  Leu Val Ser 
    1025                 1030                 1035             


Ser Ser  Gln Ser Leu Leu Glu  Trp Cys Gln Glu Val  Thr Thr Gly 
    1040                 1045                 1050             


Tyr Arg  Gly Val Arg Ile Thr  Asn Phe Thr Thr Ser  Trp Arg Asn 
    1055                 1060                 1065             


Gly Leu  Ala Phe Cys Ala Ile  Leu His Arg Phe Tyr  Pro Asp Lys 
    1070                 1075                 1080             


Ile Asp  Tyr Ala Ser Leu Asp  Pro Leu Asn Ile Lys  Gln Asn Asn 
    1085                 1090                 1095             


Lys Gln  Ala Phe Asp Gly Phe  Ala Ala Leu Gly Val  Ser Arg Leu 
    1100                 1105                 1110             


Leu Glu  Pro Ala Asp Met Val  Leu Leu Ser Val Pro  Asp Lys Leu 
    1115                 1120                 1125             


Ile Val  Met Thr Tyr Leu Cys  Gln Ile Arg Ala Phe  Cys Thr Gly 
    1130                 1135                 1140             


Gln Glu  Leu Gln Leu Val Gln  Leu Glu Gly Gly Gly  Gly Ala Gly 
    1145                 1150                 1155             


Thr Tyr  Arg Val Gly Ser Ala  Gln Pro Ser Pro Pro  Asp Asp Leu 
    1160                 1165                 1170             


Asp Ala  Gly Gly Leu Ala Gln  Arg Leu Arg Gly His  Gly Ala Glu 
    1175                 1180                 1185             


Gly Pro  Gln Glu Pro Lys Glu  Ala Ala Asp Arg Ala  Asp Gly Ala 
    1190                 1195                 1200             


Ala Pro  Gly Val Ala Ser Arg  Asn Ala Val Ala Gly  Arg Ala Ser 
    1205                 1210                 1215             


Lys Asp  Gly Gly Ala Glu Ala  Pro Arg Glu Ser Arg  Pro Ala Glu 
    1220                 1225                 1230             


Val Pro  Ala Glu Gly Leu Val  Asn Gly Ala Gly Ala  Pro Gly Gly 
    1235                 1240                 1245             


Gly Gly  Val Arg Leu Arg Arg  Pro Ser Val Asn Gly  Glu Pro Gly 
    1250                 1255                 1260             


Ser Val  Pro Pro Pro Arg Ala  His Gly Ser Phe Ser  His Val Arg 
    1265                 1270                 1275             


Asp Ala  Asp Leu Leu Lys Lys  Arg Arg Ser Arg Leu  Arg Asn Ser 
    1280                 1285                 1290             


Ser Ser  Phe Ser Met Asp Asp  Pro Asp Ala Gly Ala  Met Gly Ala 
    1295                 1300                 1305             


Ala Ala  Ala Glu Gly Gln Ala  Pro Asp Pro Ser Pro  Ala Pro Gly 
    1310                 1315                 1320             


Pro Pro  Thr Ala Ala Asp Ser  Gln Gln Pro Pro Gly  Gly Ser Ser 
    1325                 1330                 1335             


Pro Ser  Glu Glu Pro Pro Pro  Ser Pro Gly Glu Glu  Ala Gly Leu 
    1340                 1345                 1350             


Gln Arg  Phe Gln Asp Thr Ser  Gln Tyr Val Cys Ala  Glu Leu Gln 
    1355                 1360                 1365             


Ala Leu  Glu Gln Glu Gln Arg  Gln Ile Asp Gly Arg  Ala Ala Glu 
    1370                 1375                 1380             


Val Glu  Met Gln Leu Arg Ser  Leu Met Glu Ser Gly  Ala Asn Lys 
    1385                 1390                 1395             


Leu Gln  Glu Glu Val Leu Ile  Gln Glu Trp Phe Thr  Leu Val Asn 
    1400                 1405                 1410             


Lys Lys  Asn Ala Leu Ile Arg  Arg Gln Asp Gln Leu  Gln Leu Leu 
    1415                 1420                 1425             


Met Glu  Glu Gln Asp Leu Glu  Arg Arg Phe Glu Leu  Leu Ser Arg 
    1430                 1435                 1440             


Glu Leu  Arg Ala Met Leu Ala  Ile Glu Asp Trp Gln  Lys Thr Ser 
    1445                 1450                 1455             


Ala Gln  Gln His Arg Glu Gln  Leu Leu Leu Glu Glu  Leu Val Ser 
    1460                 1465                 1470             


Leu Val  Asn Gln Arg Asp Glu  Leu Val Arg Asp Leu  Asp His Lys 
    1475                 1480                 1485             


Glu Arg  Ile Ala Leu Glu Glu  Asp Glu Arg Leu Glu  Arg Gly Leu 
    1490                 1495                 1500             


Glu Gln  Arg Arg Arg Lys Leu  Ser Arg Gln Leu Ser  Arg Arg Glu 
    1505                 1510                 1515             


Arg Cys  Val Leu Ser 
    1520             


<210>  107
<211>  1631
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Glu Arg Arg Ala Ala Gly Pro Gly Trp Ala Ala Tyr Glu Arg Leu 
1               5                   10                  15      


Thr Ala Glu Glu Met Asp Glu Gln Arg Arg Gln Asn Val Ala Tyr Gln 
            20                  25                  30          


Tyr Leu Cys Arg Leu Glu Glu Ala Lys Arg Trp Met Glu Ala Cys Leu 
        35                  40                  45              


Lys Glu Glu Leu Pro Ser Pro Val Glu Leu Glu Glu Ser Leu Arg Asn 
    50                  55                  60                  


Gly Val Leu Leu Ala Lys Leu Gly His Cys Phe Ala Pro Ser Val Val 
65                  70                  75                  80  


Pro Leu Lys Lys Ile Tyr Asp Val Glu Gln Leu Arg Tyr Gln Ala Thr 
                85                  90                  95      


Gly Leu His Phe Arg His Thr Asp Asn Ile Asn Phe Trp Leu Ser Ala 
            100                 105                 110         


Ile Ala His Ile Gly Leu Pro Ser Thr Phe Phe Pro Glu Thr Thr Asp 
        115                 120                 125             


Ile Tyr Asp Lys Lys Asn Met Pro Arg Val Val Tyr Cys Ile His Ala 
    130                 135                 140                 


Leu Ser Leu Phe Leu Phe Arg Leu Gly Leu Ala Pro Gln Ile His Asp 
145                 150                 155                 160 


Leu Tyr Gly Lys Val Lys Phe Thr Ala Glu Glu Leu Ser Asn Met Ala 
                165                 170                 175     


Ser Glu Leu Ala Lys Tyr Gly Leu Gln Leu Pro Ala Phe Ser Lys Ile 
            180                 185                 190         


Gly Gly Ile Leu Ala Asn Glu Leu Ser Val Asp Glu Ala Ala Val His 
        195                 200                 205             


Ala Ala Val Leu Ala Ile Asn Glu Ala Val Glu Arg Gly Val Val Glu 
    210                 215                 220                 


Asp Thr Leu Ala Ala Leu Gln Asn Pro Ser Ala Leu Leu Glu Asn Leu 
225                 230                 235                 240 


Arg Glu Pro Leu Ala Ala Val Tyr Gln Glu Met Leu Ala Gln Ala Lys 
                245                 250                 255     


Met Glu Lys Ala Ala Asn Ala Arg Asn His Asp Asp Arg Glu Ser Gln 
            260                 265                 270         


Asp Ile Tyr Asp His Tyr Leu Thr Gln Ala Glu Ile Gln Gly Asn Ile 
        275                 280                 285             


Asn His Val Asn Val His Gly Ala Leu Glu Val Val Asp Asp Ala Leu 
    290                 295                 300                 


Glu Arg Gln Ser Pro Glu Ala Leu Leu Lys Ala Leu Gln Asp Pro Ala 
305                 310                 315                 320 


Leu Ala Leu Arg Gly Val Arg Arg Asp Phe Ala Asp Trp Tyr Leu Glu 
                325                 330                 335     


Gln Leu Asn Ser Asp Arg Glu Gln Lys Ala Gln Glu Leu Gly Leu Val 
            340                 345                 350         


Glu Leu Leu Glu Lys Glu Glu Val Gln Ala Gly Val Ala Ala Ala Asn 
        355                 360                 365             


Thr Lys Gly Asp Gln Glu Gln Ala Met Leu His Ala Val Gln Arg Ile 
    370                 375                 380                 


Asn Lys Ala Ile Arg Arg Arg Val Ala Ala Asp Thr Val Lys Glu Leu 
385                 390                 395                 400 


Met Cys Pro Glu Ala Gln Leu Pro Pro Val Tyr Pro Val Ala Ser Ser 
                405                 410                 415     


Met Tyr Gln Leu Glu Leu Ala Val Leu Gln Gln Gln Gln Gly Glu Leu 
            420                 425                 430         


Gly Gln Glu Glu Leu Phe Val Ala Val Glu Met Leu Ser Ala Val Val 
        435                 440                 445             


Leu Ile Asn Arg Ala Leu Glu Ala Arg Asp Ala Ser Gly Phe Trp Ser 
    450                 455                 460                 


Ser Leu Val Asn Pro Ala Thr Gly Leu Ala Glu Val Glu Gly Glu Asn 
465                 470                 475                 480 


Ala Gln Arg Tyr Phe Asp Ala Leu Leu Lys Leu Arg Gln Glu Arg Gly 
                485                 490                 495     


Met Gly Glu Asp Phe Leu Ser Trp Asn Asp Leu Gln Ala Thr Val Ser 
            500                 505                 510         


Gln Val Asn Ala Gln Thr Gln Glu Glu Thr Asp Arg Val Leu Ala Val 
        515                 520                 525             


Ser Leu Ile Asn Glu Ala Leu Asp Lys Gly Ser Pro Glu Lys Thr Leu 
    530                 535                 540                 


Ser Ala Leu Leu Leu Pro Ala Ala Gly Leu Asp Asp Val Ser Leu Pro 
545                 550                 555                 560 


Val Ala Pro Arg Tyr His Leu Leu Leu Val Ala Ala Lys Arg Gln Lys 
                565                 570                 575     


Ala Gln Val Thr Gly Asp Pro Gly Ala Val Leu Trp Leu Glu Glu Ile 
            580                 585                 590         


Arg Gln Gly Val Val Arg Ala Asn Gln Asp Thr Asn Thr Ala Gln Arg 
        595                 600                 605             


Met Ala Leu Gly Val Ala Ala Ile Asn Gln Ala Ile Lys Glu Gly Lys 
    610                 615                 620                 


Ala Ala Gln Thr Glu Arg Val Leu Arg Asn Pro Ala Val Ala Leu Arg 
625                 630                 635                 640 


Gly Val Val Pro Asp Cys Ala Asn Gly Tyr Gln Arg Ala Leu Glu Ser 
                645                 650                 655     


Ala Met Ala Lys Lys Gln Arg Pro Ala Asp Thr Ala Phe Trp Val Gln 
            660                 665                 670         


His Asp Met Lys Asp Gly Thr Ala Tyr Tyr Phe His Leu Gln Thr Phe 
        675                 680                 685             


Gln Gly Ile Trp Glu Gln Pro Pro Gly Cys Pro Leu Asn Thr Ser His 
    690                 695                 700                 


Leu Thr Arg Glu Glu Ile Gln Ser Ala Val Thr Lys Val Thr Ala Ala 
705                 710                 715                 720 


Tyr Asp Arg Gln Gln Leu Trp Lys Ala Asn Val Gly Phe Val Ile Gln 
                725                 730                 735     


Leu Gln Ala Arg Leu Arg Gly Phe Leu Val Arg Gln Lys Phe Ala Glu 
            740                 745                 750         


His Ser His Phe Leu Arg Thr Trp Leu Pro Ala Val Ile Lys Ile Gln 
        755                 760                 765             


Ala His Trp Arg Gly Tyr Arg Gln Arg Lys Ile Tyr Leu Glu Trp Leu 
    770                 775                 780                 


Gln Tyr Phe Lys Ala Asn Leu Asp Ala Ile Ile Lys Ile Gln Ala Trp 
785                 790                 795                 800 


Ala Arg Met Trp Ala Ala Arg Arg Gln Tyr Leu Arg Arg Leu His Tyr 
                805                 810                 815     


Phe Gln Lys Asn Val Asn Ser Ile Val Lys Ile Gln Ala Phe Phe Arg 
            820                 825                 830         


Ala Arg Lys Ala Gln Asp Asp Tyr Arg Ile Leu Val His Ala Pro His 
        835                 840                 845             


Pro Pro Leu Ser Val Val Arg Arg Phe Ala His Leu Leu Asn Gln Ser 
    850                 855                 860                 


Gln Gln Asp Phe Leu Ala Glu Ala Glu Leu Leu Lys Leu Gln Glu Glu 
865                 870                 875                 880 


Val Val Arg Lys Ile Arg Ser Asn Gln Gln Leu Glu Gln Asp Leu Asn 
                885                 890                 895     


Ile Met Asp Ile Lys Ile Gly Leu Leu Val Lys Asn Arg Ile Thr Leu 
            900                 905                 910         


Gln Glu Val Val Ser His Cys Lys Lys Leu Thr Lys Arg Asn Lys Glu 
        915                 920                 925             


Gln Leu Ser Asp Met Met Val Leu Asp Lys Gln Lys Gly Leu Lys Ser 
    930                 935                 940                 


Leu Ser Lys Glu Lys Arg Gln Lys Leu Glu Ala Tyr Gln His Leu Phe 
945                 950                 955                 960 


Tyr Leu Leu Gln Thr Gln Pro Ile Tyr Leu Ala Lys Leu Ile Phe Gln 
                965                 970                 975     


Met Pro Gln Asn Lys Thr Thr Lys Phe Met Glu Ala Val Ile Phe Ser 
            980                 985                 990         


Leu Tyr Asn Tyr Ala Ser Ser Arg  Arg Glu Ala Tyr Leu  Leu Leu Gln 
        995                 1000                 1005             


Leu Phe  Lys Thr Ala Leu Gln  Glu Glu Ile Lys Ser  Lys Val Glu 
    1010                 1015                 1020             


Gln Pro  Gln Asp Val Val Thr  Gly Asn Pro Thr Val  Val Arg Leu 
    1025                 1030                 1035             


Val Val  Arg Phe Tyr Arg Asn  Gly Arg Gly Gln Ser  Ala Leu Gln 
    1040                 1045                 1050             


Glu Ile  Leu Gly Lys Val Ile  Gln Asp Val Leu Glu  Asp Lys Val 
    1055                 1060                 1065             


Leu Ser  Val His Thr Asp Pro  Val His Leu Tyr Lys  Asn Trp Ile 
    1070                 1075                 1080             


Asn Gln  Thr Glu Ala Gln Thr  Gly Gln Arg Ser His  Leu Pro Tyr 
    1085                 1090                 1095             


Asp Val  Thr Pro Glu Gln Ala  Leu Ser His Pro Glu  Val Gln Arg 
    1100                 1105                 1110             


Arg Leu  Asp Ile Ala Leu Arg  Asn Leu Leu Ala Met  Thr Asp Lys 
    1115                 1120                 1125             


Phe Leu  Leu Ala Ile Thr Ser  Ser Val Asp Gln Ile  Pro Tyr Gly 
    1130                 1135                 1140             


Met Arg  Tyr Val Ala Lys Val  Leu Lys Ala Thr Leu  Ala Glu Lys 
    1145                 1150                 1155             


Phe Pro  Asp Ala Thr Asp Ser  Glu Val Tyr Lys Val  Val Gly Asn 
    1160                 1165                 1170             


Leu Leu  Tyr Tyr Arg Phe Leu  Asn Pro Ala Val Val  Ala Pro Asp 
    1175                 1180                 1185             


Ala Phe  Asp Ile Val Ala Met  Ala Ala Gly Gly Ala  Leu Ala Ala 
    1190                 1195                 1200             


Pro Gln  Arg His Ala Leu Gly  Ala Val Ala Gln Leu  Leu Gln His 
    1205                 1210                 1215             


Ala Ala  Ala Gly Lys Ala Phe  Ser Gly Gln Ser Gln  His Leu Arg 
    1220                 1225                 1230             


Val Leu  Asn Asp Tyr Leu Glu  Glu Thr His Leu Lys  Phe Arg Lys 
    1235                 1240                 1245             


Phe Ile  His Arg Ala Cys Gln  Val Pro Glu Pro Glu  Glu Arg Phe 
    1250                 1255                 1260             


Ala Val  Asp Glu Tyr Ser Asp  Met Val Ala Val Ala  Lys Pro Met 
    1265                 1270                 1275             


Val Tyr  Ile Thr Val Gly Glu  Leu Val Asn Thr His  Arg Leu Leu 
    1280                 1285                 1290             


Leu Glu  His Gln Asp Cys Ile  Ala Pro Asp His Gln  Asp Pro Leu 
    1295                 1300                 1305             


His Glu  Leu Leu Glu Asp Leu  Gly Glu Leu Pro Thr  Ile Pro Asp 
    1310                 1315                 1320             


Leu Ile  Gly Glu Ser Ile Ala  Ala Asp Gly His Thr  Asp Leu Ser 
    1325                 1330                 1335             


Lys Leu  Glu Val Ser Leu Thr  Leu Thr Asn Lys Phe  Glu Gly Leu 
    1340                 1345                 1350             


Glu Ala  Asp Ala Asp Asp Ser  Asn Thr Arg Ser Leu  Leu Leu Ser 
    1355                 1360                 1365             


Thr Lys  Gln Leu Leu Ala Asp  Ile Ile Gln Phe His  Pro Gly Asp 
    1370                 1375                 1380             


Thr Leu  Lys Glu Ile Leu Ser  Leu Ser Ala Ser Arg  Glu Gln Glu 
    1385                 1390                 1395             


Ala Ala  His Lys Gln Leu Met  Ser Arg Arg Gln Ala  Cys Thr Ala 
    1400                 1405                 1410             


Gln Thr  Pro Glu Pro Leu Arg  Arg His Arg Ser Leu  Thr Ala His 
    1415                 1420                 1425             


Ser Leu  Leu Pro Leu Ala Glu  Lys Gln Arg Arg Val  Leu Arg Asn 
    1430                 1435                 1440             


Leu Arg  Arg Leu Glu Ala Leu  Gly Leu Val Ser Ala  Arg Asn Gly 
    1445                 1450                 1455             


Tyr Gln  Gly Leu Val Asp Glu  Leu Ala Lys Asp Ile  Arg Asn Gln 
    1460                 1465                 1470             


His Arg  His Arg His Arg Arg  Lys Ala Glu Leu Val  Lys Leu Gln 
    1475                 1480                 1485             


Ala Thr  Leu Gln Gly Leu Ser  Thr Lys Thr Thr Phe  Tyr Glu Glu 
    1490                 1495                 1500             


Gln Gly  Asp Tyr Tyr Ser Gln  Tyr Ile Arg Ala Cys  Leu Asp His 
    1505                 1510                 1515             


Leu Ala  Pro Asp Ser Lys Ser  Ser Gly Lys Gly Lys  Lys Gln Pro 
    1520                 1525                 1530             


Ser Leu  His Tyr Thr Ala Ala  Gln Leu Leu Glu Lys  Gly Val Leu 
    1535                 1540                 1545             


Val Glu  Ile Glu Asp Leu Pro  Ala Ser His Phe Arg  Asn Val Ile 
    1550                 1555                 1560             


Phe Asp  Ile Thr Pro Gly Asp  Glu Ala Gly Lys Phe  Glu Val Asn 
    1565                 1570                 1575             


Ala Lys  Phe Leu Gly Val Asp  Met Glu Arg Phe Gln  Leu His Tyr 
    1580                 1585                 1590             


Gln Asp  Leu Leu Gln Leu Gln  Tyr Glu Gly Val Ala  Val Met Lys 
    1595                 1600                 1605             


Leu Phe  Asn Lys Ala Lys Val  Asn Val Asn Leu Leu  Ile Phe Leu 
    1610                 1615                 1620             


Leu Asn  Lys Lys Phe Leu Arg  Lys 
    1625                 1630     


<210>  108
<211>  774
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Glu Arg Pro Leu Cys Ser His Leu Cys Ser Cys Leu Ala Met Leu 
1               5                   10                  15      


Ala Leu Leu Ser Pro Leu Ser Leu Ala Gln Tyr Asp Ser Trp Pro His 
            20                  25                  30          


Tyr Pro Glu Tyr Phe Gln Gln Pro Ala Pro Glu Tyr His Gln Pro Gln 
        35                  40                  45              


Ala Pro Ala Asn Val Ala Lys Ile Gln Leu Arg Leu Ala Gly Gln Lys 
    50                  55                  60                  


Arg Lys His Ser Glu Gly Arg Val Glu Val Tyr Tyr Asp Gly Gln Trp 
65                  70                  75                  80  


Gly Thr Val Cys Asp Asp Asp Phe Ser Ile His Ala Ala His Val Val 
                85                  90                  95      


Cys Arg Glu Leu Gly Tyr Val Glu Ala Lys Ser Trp Thr Ala Ser Ser 
            100                 105                 110         


Ser Tyr Gly Lys Gly Glu Gly Pro Ile Trp Leu Asp Asn Leu His Cys 
        115                 120                 125             


Thr Gly Asn Glu Ala Thr Leu Ala Ala Cys Thr Ser Asn Gly Trp Gly 
    130                 135                 140                 


Val Thr Asp Cys Lys His Thr Glu Asp Val Gly Val Val Cys Ser Asp 
145                 150                 155                 160 


Lys Arg Ile Pro Gly Phe Lys Phe Asp Asn Ser Leu Ile Asn Gln Ile 
                165                 170                 175     


Glu Asn Leu Asn Ile Gln Val Glu Asp Ile Arg Ile Arg Ala Ile Leu 
            180                 185                 190         


Ser Thr Tyr Arg Lys Arg Thr Pro Val Met Glu Gly Tyr Val Glu Val 
        195                 200                 205             


Lys Glu Gly Lys Thr Trp Lys Gln Ile Cys Asp Lys His Trp Thr Ala 
    210                 215                 220                 


Lys Asn Ser Arg Val Val Cys Gly Met Phe Gly Phe Pro Gly Glu Arg 
225                 230                 235                 240 


Thr Tyr Asn Thr Lys Val Tyr Lys Met Phe Ala Ser Arg Arg Lys Gln 
                245                 250                 255     


Arg Tyr Trp Pro Phe Ser Met Asp Cys Thr Gly Thr Glu Ala His Ile 
            260                 265                 270         


Ser Ser Cys Lys Leu Gly Pro Gln Val Ser Leu Asp Pro Met Lys Asn 
        275                 280                 285             


Val Thr Cys Glu Asn Gly Leu Pro Ala Val Val Ser Cys Val Pro Gly 
    290                 295                 300                 


Gln Val Phe Ser Pro Asp Gly Pro Ser Arg Phe Arg Lys Ala Tyr Lys 
305                 310                 315                 320 


Pro Glu Gln Pro Leu Val Arg Leu Arg Gly Gly Ala Tyr Ile Gly Glu 
                325                 330                 335     


Gly Arg Val Glu Val Leu Lys Asn Gly Glu Trp Gly Thr Val Cys Asp 
            340                 345                 350         


Asp Lys Trp Asp Leu Val Ser Ala Ser Val Val Cys Arg Glu Leu Gly 
        355                 360                 365             


Phe Gly Ser Ala Lys Glu Ala Val Thr Gly Ser Arg Leu Gly Gln Gly 
    370                 375                 380                 


Ile Gly Pro Ile His Leu Asn Glu Ile Gln Cys Thr Gly Asn Glu Lys 
385                 390                 395                 400 


Ser Ile Ile Asp Cys Lys Phe Asn Ala Glu Ser Gln Gly Cys Asn His 
                405                 410                 415     


Glu Glu Asp Ala Gly Val Arg Cys Asn Thr Pro Ala Met Gly Leu Gln 
            420                 425                 430         


Lys Lys Leu Arg Leu Asn Gly Gly Arg Asn Pro Tyr Glu Gly Arg Val 
        435                 440                 445             


Glu Val Leu Val Glu Arg Asn Gly Ser Leu Val Trp Gly Met Val Cys 
    450                 455                 460                 


Gly Gln Asn Trp Gly Ile Val Glu Ala Met Val Val Cys Arg Gln Leu 
465                 470                 475                 480 


Gly Leu Gly Phe Ala Ser Asn Ala Phe Gln Glu Thr Trp Tyr Trp His 
                485                 490                 495     


Gly Asp Val Asn Ser Asn Lys Val Val Met Ser Gly Val Lys Cys Ser 
            500                 505                 510         


Gly Thr Glu Leu Ser Leu Ala His Cys Arg His Asp Gly Glu Asp Val 
        515                 520                 525             


Ala Cys Pro Gln Gly Gly Val Gln Tyr Gly Ala Gly Val Ala Cys Ser 
    530                 535                 540                 


Glu Thr Ala Pro Asp Leu Val Leu Asn Ala Glu Met Val Gln Gln Thr 
545                 550                 555                 560 


Thr Tyr Leu Glu Asp Arg Pro Met Phe Met Leu Gln Cys Ala Met Glu 
                565                 570                 575     


Glu Asn Cys Leu Ser Ala Ser Ala Ala Gln Thr Asp Pro Thr Thr Gly 
            580                 585                 590         


Tyr Arg Arg Leu Leu Arg Phe Ser Ser Gln Ile His Asn Asn Gly Gln 
        595                 600                 605             


Ser Asp Phe Arg Pro Lys Asn Gly Arg His Ala Trp Ile Trp His Asp 
    610                 615                 620                 


Cys His Arg His Tyr His Ser Met Glu Val Phe Thr His Tyr Asp Leu 
625                 630                 635                 640 


Leu Asn Leu Asn Gly Thr Lys Val Ala Glu Gly His Lys Ala Ser Phe 
                645                 650                 655     


Cys Leu Glu Asp Thr Glu Cys Glu Gly Asp Ile Gln Lys Asn Tyr Glu 
            660                 665                 670         


Cys Ala Asn Phe Gly Asp Gln Gly Ile Thr Met Gly Cys Trp Asp Met 
        675                 680                 685             


Tyr Arg His Asp Ile Asp Cys Gln Trp Val Asp Ile Thr Asp Val Pro 
    690                 695                 700                 


Pro Gly Asp Tyr Leu Phe Gln Val Val Ile Asn Pro Asn Phe Glu Val 
705                 710                 715                 720 


Ala Glu Ser Asp Tyr Ser Asn Asn Ile Met Lys Cys Arg Ser Arg Tyr 
                725                 730                 735     


Asp Gly His Arg Ile Trp Met Tyr Asn Cys His Ile Gly Gly Ser Phe 
            740                 745                 750         


Ser Glu Glu Thr Glu Lys Lys Phe Glu His Phe Ser Gly Leu Leu Asn 
        755                 760                 765             


Asn Gln Leu Ser Pro Gln 
    770                 


<210>  109
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
1               5                   10                  15      


Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
            20                  25                  30          


Glu Asp Arg Ser Lys Gln Leu Glu Glu Asp Ile Ala Ala Lys Glu Lys 
        35                  40                  45              


Leu Leu Arg Val Ser Glu Asp Glu Arg Asp Arg Val Leu Glu Glu Leu 
    50                  55                  60                  


His Lys Ala Glu Asp Ser Leu Leu Ala Ala Glu Glu Ala Ala Ala Lys 
65                  70                  75                  80  


Leu Glu Asp Glu Leu Val Ser Leu Gln Lys Lys Leu Lys Gly Thr Glu 
                85                  90                  95      


Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu Lys Asp Ala Gln Glu Lys 
            100                 105                 110         


Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp Ala Glu Ala Asp Val Ala 
        115                 120                 125             


Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp Arg Ala 
    130                 135                 140                 


Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala Glu Lys 
145                 150                 155                 160 


Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Ser Arg Ala 
                165                 170                 175     


Gln Lys Asp Glu Glu Lys Met Glu Ile Gln Glu Ile Gln Leu Lys Glu 
            180                 185                 190         


Ala Lys His Ile Ala Glu Asp Ala Asp Arg Lys Tyr Glu Glu Val Ala 
        195                 200                 205             


Arg Lys Leu Val Ile Ile Glu Ser Asp Leu Glu Arg Ala Glu Glu Arg 
    210                 215                 220                 


Ala Glu Leu Ser Glu Gly Lys Cys Ala Glu Leu Glu Glu Glu Leu Lys 
225                 230                 235                 240 


Thr Val Thr Asn Asn Leu Lys Ser Leu Glu Ala Gln Ala Glu Lys Tyr 
                245                 250                 255     


Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu Ile Lys Val Leu Ser Asp 
            260                 265                 270         


Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg Ser Val 
        275                 280                 285             


Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu Glu Glu Lys Val Ala His 
    290                 295                 300                 


Ala Lys Glu Glu Asn Leu Ser Met His Gln Met Leu Asp Gln Thr Leu 
305                 310                 315                 320 


Leu Glu Leu Asn Asn Met 
                325     


<210>  110
<211>  1508
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Gly Gln Glu Pro Arg Thr Leu Pro Pro Ser Pro Asn Trp Tyr Cys 
1               5                   10                  15      


Ala Arg Cys Ser Asp Ala Val Pro Gly Gly Leu Phe Gly Phe Ala Ala 
            20                  25                  30          


Arg Thr Ser Val Phe Leu Val Arg Val Gly Pro Gly Ala Gly Glu Ser 
        35                  40                  45              


Pro Gly Thr Pro Pro Phe Arg Val Ile Gly Glu Leu Val Gly His Thr 
    50                  55                  60                  


Glu Arg Val Ser Gly Phe Thr Phe Ser His His Pro Gly Gln Tyr Asn 
65                  70                  75                  80  


Leu Cys Ala Thr Ser Ser Asp Asp Gly Thr Val Lys Ile Trp Asp Val 
                85                  90                  95      


Glu Thr Lys Thr Val Val Thr Glu His Ala Leu His Gln His Thr Ile 
            100                 105                 110         


Ser Thr Leu His Trp Ser Pro Arg Val Lys Asp Leu Ile Val Ser Gly 
        115                 120                 125             


Asp Glu Lys Gly Val Val Phe Cys Tyr Trp Phe Asn Arg Asn Asp Ser 
    130                 135                 140                 


Gln His Leu Phe Ile Glu Pro Arg Thr Ile Phe Cys Leu Thr Cys Ser 
145                 150                 155                 160 


Pro His His Glu Asp Leu Val Ala Ile Gly Tyr Lys Asp Gly Ile Val 
                165                 170                 175     


Val Ile Ile Asp Ile Ser Lys Lys Gly Glu Val Ile His Arg Leu Arg 
            180                 185                 190         


Gly His Asp Asp Glu Ile His Ser Ile Ala Trp Cys Pro Leu Pro Gly 
        195                 200                 205             


Glu Asp Cys Leu Ser Ile Asn Gln Glu Glu Thr Ser Glu Glu Ala Glu 
    210                 215                 220                 


Ile Thr Asn Gly Asn Ala Val Ala Gln Ala Pro Val Thr Lys Gly Cys 
225                 230                 235                 240 


Tyr Leu Ala Thr Gly Ser Lys Asp Gln Thr Ile Arg Ile Trp Ser Cys 
                245                 250                 255     


Ser Arg Gly Arg Gly Val Met Ile Leu Lys Leu Pro Phe Leu Lys Arg 
            260                 265                 270         


Arg Gly Gly Gly Ile Asp Pro Thr Val Lys Glu Arg Leu Trp Leu Thr 
        275                 280                 285             


Leu His Trp Pro Ser Asn Gln Pro Thr Gln Leu Val Ser Ser Cys Phe 
    290                 295                 300                 


Gly Gly Glu Leu Leu Gln Trp Asp Leu Thr Gln Ser Trp Arg Arg Lys 
305                 310                 315                 320 


Tyr Thr Leu Phe Ser Ala Ser Ser Glu Gly Gln Asn His Ser Arg Ile 
                325                 330                 335     


Val Phe Asn Leu Cys Pro Leu Gln Thr Glu Asp Asp Lys Gln Leu Leu 
            340                 345                 350         


Leu Ser Thr Ser Met Asp Arg Asp Val Lys Cys Trp Asp Ile Ala Thr 
        355                 360                 365             


Leu Glu Cys Ser Trp Thr Leu Pro Ser Leu Gly Gly Phe Ala Tyr Ser 
    370                 375                 380                 


Leu Ala Phe Ser Ser Val Asp Ile Gly Ser Leu Ala Ile Gly Val Gly 
385                 390                 395                 400 


Asp Gly Met Ile Arg Val Trp Asn Thr Leu Ser Ile Lys Asn Asn Tyr 
                405                 410                 415     


Asp Val Lys Asn Phe Trp Gln Gly Val Lys Ser Lys Val Thr Ala Leu 
            420                 425                 430         


Cys Trp His Pro Thr Lys Glu Gly Cys Leu Ala Phe Gly Thr Asp Asp 
        435                 440                 445             


Gly Lys Val Gly Leu Tyr Asp Thr Tyr Ser Asn Lys Pro Pro Gln Ile 
    450                 455                 460                 


Ser Ser Thr Tyr His Lys Lys Thr Val Tyr Thr Leu Ala Trp Gly Pro 
465                 470                 475                 480 


Pro Val Pro Pro Met Ser Leu Gly Gly Glu Gly Asp Arg Pro Ser Leu 
                485                 490                 495     


Ala Leu Tyr Ser Cys Gly Gly Glu Gly Ile Val Leu Gln His Asn Pro 
            500                 505                 510         


Trp Lys Leu Ser Gly Glu Ala Phe Asp Ile Asn Lys Leu Ile Arg Asp 
        515                 520                 525             


Thr Asn Ser Ile Lys Tyr Lys Leu Pro Val His Thr Glu Ile Ser Trp 
    530                 535                 540                 


Lys Ala Asp Gly Lys Ile Met Ala Leu Gly Asn Glu Asp Gly Ser Ile 
545                 550                 555                 560 


Glu Ile Phe Gln Ile Pro Asn Leu Lys Leu Ile Cys Thr Ile Gln Gln 
                565                 570                 575     


His His Lys Leu Val Asn Thr Ile Ser Trp His His Glu His Gly Ser 
            580                 585                 590         


Gln Pro Glu Leu Ser Tyr Leu Met Ala Ser Gly Ser Asn Asn Ala Val 
        595                 600                 605             


Ile Tyr Val His Asn Leu Lys Thr Val Ile Glu Ser Ser Pro Glu Ser 
    610                 615                 620                 


Pro Val Thr Ile Thr Glu Pro Tyr Arg Thr Leu Ser Gly His Thr Ala 
625                 630                 635                 640 


Lys Ile Thr Ser Val Ala Trp Ser Pro His His Asp Gly Arg Leu Val 
                645                 650                 655     


Ser Ala Ser Tyr Asp Gly Thr Ala Gln Val Trp Asp Ala Leu Arg Glu 
            660                 665                 670         


Glu Pro Leu Cys Asn Phe Arg Gly His Arg Gly Arg Leu Leu Cys Val 
        675                 680                 685             


Ala Trp Ser Pro Leu Asp Pro Asp Cys Ile Tyr Ser Gly Ala Asp Asp 
    690                 695                 700                 


Phe Cys Val His Lys Trp Leu Thr Ser Met Gln Asp His Ser Arg Pro 
705                 710                 715                 720 


Pro Gln Gly Lys Lys Ser Ile Glu Leu Glu Lys Lys Arg Leu Ser Gln 
                725                 730                 735     


Pro Lys Ala Lys Pro Lys Lys Lys Lys Lys Pro Thr Leu Arg Thr Pro 
            740                 745                 750         


Val Lys Leu Glu Ser Ile Asp Gly Asn Glu Glu Glu Ser Met Lys Glu 
        755                 760                 765             


Asn Ser Gly Pro Val Glu Asn Gly Val Ser Asp Gln Glu Gly Glu Glu 
    770                 775                 780                 


Gln Ala Arg Glu Pro Glu Leu Pro Cys Gly Leu Ala Pro Ala Val Ser 
785                 790                 795                 800 


Arg Glu Pro Val Ile Cys Thr Pro Val Ser Ser Gly Phe Glu Lys Ser 
                805                 810                 815     


Lys Val Thr Ile Asn Asn Lys Val Ile Leu Leu Lys Lys Glu Pro Pro 
            820                 825                 830         


Lys Glu Lys Pro Glu Thr Leu Ile Lys Lys Arg Lys Ala Arg Ser Leu 
        835                 840                 845             


Leu Pro Leu Ser Thr Ser Leu Asp His Arg Ser Lys Glu Glu Leu His 
    850                 855                 860                 


Gln Asp Cys Leu Val Leu Ala Thr Ala Lys His Ser Arg Glu Leu Asn 
865                 870                 875                 880 


Glu Asp Val Ser Ala Asp Val Glu Glu Arg Phe His Leu Gly Leu Phe 
                885                 890                 895     


Thr Asp Arg Ala Thr Leu Tyr Arg Met Ile Asp Ile Glu Gly Lys Gly 
            900                 905                 910         


His Leu Glu Asn Gly His Pro Glu Leu Phe His Gln Leu Met Leu Trp 
        915                 920                 925             


Lys Gly Asp Leu Lys Gly Val Leu Gln Thr Ala Ala Glu Arg Gly Glu 
    930                 935                 940                 


Leu Thr Asp Asn Leu Val Ala Met Ala Pro Ala Ala Gly Tyr His Val 
945                 950                 955                 960 


Trp Leu Trp Ala Val Glu Ala Phe Ala Lys Gln Leu Cys Phe Gln Asp 
                965                 970                 975     


Gln Tyr Val Lys Ala Ala Ser His Leu Leu Ser Ile His Lys Val Tyr 
            980                 985                 990         


Glu Ala Val Glu Leu Leu Lys Ser  Asn His Phe Tyr Arg  Glu Ala Ile 
        995                 1000                 1005             


Ala Ile  Ala Lys Ala Arg Leu  Arg Pro Glu Asp Pro  Val Leu Lys 
    1010                 1015                 1020             


Asp Leu  Tyr Leu Ser Trp Gly  Thr Val Leu Glu Arg  Asp Gly His 
    1025                 1030                 1035             


Tyr Ala  Val Ala Ala Lys Cys  Tyr Leu Gly Ala Thr  Cys Ala Tyr 
    1040                 1045                 1050             


Asp Ala  Ala Lys Val Leu Ala  Lys Lys Gly Asp Ala  Ala Ser Leu 
    1055                 1060                 1065             


Arg Thr  Ala Ala Glu Leu Ala  Ala Ile Val Gly Glu  Asp Glu Leu 
    1070                 1075                 1080             


Ser Ala  Ser Leu Ala Leu Arg  Cys Ala Gln Glu Leu  Leu Leu Ala 
    1085                 1090                 1095             


Asn Asn  Trp Val Gly Ala Gln  Glu Ala Leu Gln Leu  His Glu Ser 
    1100                 1105                 1110             


Leu Gln  Gly Gln Arg Leu Val  Phe Cys Leu Leu Glu  Leu Leu Ser 
    1115                 1120                 1125             


Arg His  Leu Glu Glu Lys Gln  Leu Ser Glu Gly Lys  Ser Ser Ser 
    1130                 1135                 1140             


Ser Tyr  His Thr Trp Asn Thr  Gly Thr Glu Gly Pro  Phe Val Glu 
    1145                 1150                 1155             


Arg Val  Thr Ala Val Trp Lys  Ser Ile Phe Ser Leu  Asp Thr Pro 
    1160                 1165                 1170             


Glu Gln  Tyr Gln Glu Ala Phe  Gln Lys Leu Gln Asn  Ile Lys Tyr 
    1175                 1180                 1185             


Pro Ser  Ala Thr Asn Asn Thr  Pro Ala Lys Gln Leu  Leu Leu His 
    1190                 1195                 1200             


Ile Cys  His Asp Leu Thr Leu  Ala Val Leu Ser Gln  Gln Met Ala 
    1205                 1210                 1215             


Ser Trp  Asp Glu Ala Val Gln  Ala Leu Leu Arg Ala  Val Val Arg 
    1220                 1225                 1230             


Ser Tyr  Asp Ser Gly Ser Phe  Thr Ile Met Gln Glu  Val Tyr Ser 
    1235                 1240                 1245             


Ala Phe  Leu Pro Asp Gly Cys  Asp His Leu Arg Asp  Lys Leu Gly 
    1250                 1255                 1260             


Asp His  Gln Ser Pro Ala Thr  Pro Ala Phe Lys Ser  Leu Glu Ala 
    1265                 1270                 1275             


Phe Phe  Leu Tyr Gly Arg Leu  Tyr Glu Phe Trp Trp  Ser Leu Ser 
    1280                 1285                 1290             


Arg Pro  Cys Pro Asn Ser Ser  Val Trp Val Arg Ala  Gly His Arg 
    1295                 1300                 1305             


Thr Leu  Ser Val Glu Pro Ser  Gln Gln Leu Asp Thr  Ala Ser Thr 
    1310                 1315                 1320             


Glu Glu  Thr Asp Pro Glu Thr  Ser Gln Pro Glu Pro  Asn Arg Pro 
    1325                 1330                 1335             


Ser Glu  Leu Asp Leu Arg Leu  Thr Glu Glu Gly Glu  Arg Met Leu 
    1340                 1345                 1350             


Ser Thr  Phe Lys Glu Leu Phe  Ser Glu Lys His Ala  Ser Leu Gln 
    1355                 1360                 1365             


Asn Ser  Gln Arg Thr Val Ala  Glu Val Gln Glu Thr  Leu Ala Glu 
    1370                 1375                 1380             


Met Ile  Arg Gln His Gln Lys  Ser Gln Leu Cys Lys  Ser Thr Ala 
    1385                 1390                 1395             


Asn Gly  Pro Asp Lys Asn Glu  Pro Glu Val Glu Ala  Glu Gln Pro 
    1400                 1405                 1410             


Leu Cys  Ser Ser Gln Ser Gln  Cys Lys Glu Glu Lys  Asn Glu Pro 
    1415                 1420                 1425             


Leu Ser  Leu Pro Glu Leu Thr  Lys Arg Leu Thr Glu  Ala Asn Gln 
    1430                 1435                 1440             


Arg Met  Ala Lys Phe Pro Glu  Ser Ile Lys Ala Trp  Pro Phe Pro 
    1445                 1450                 1455             


Asp Val  Leu Glu Cys Cys Leu  Val Leu Leu Leu Ile  Arg Ser His 
    1460                 1465                 1470             


Phe Pro  Gly Cys Leu Ala Gln  Glu Met Gln Gln Gln  Ala Gln Glu 
    1475                 1480                 1485             


Leu Leu  Gln Lys Tyr Gly Asn  Thr Lys Thr Tyr Arg  Arg His Cys 
    1490                 1495                 1500             


Gln Thr  Phe Cys Met 
    1505             


<210>  111
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Ala Glu Leu Asp Leu Met Ala Pro Gly Pro Leu Pro Arg Ala Thr 
1               5                   10                  15      


Ala Gln Pro Pro Ala Pro Leu Ser Pro Asp Ser Gly Ser Pro Ser Pro 
            20                  25                  30          


Asp Ser Gly Ser Ala Ser Pro Val Glu Glu Glu Asp Val Gly Ser Ser 
        35                  40                  45              


Glu Lys Leu Gly Arg Glu Thr Glu Glu Gln Asp Ser Asp Ser Ala Glu 
    50                  55                  60                  


Gln Gly Asp Pro Ala Gly Glu Gly Lys Glu Val Leu Cys Asp Phe Cys 
65                  70                  75                  80  


Leu Asp Asp Thr Arg Arg Val Lys Ala Val Lys Ser Cys Leu Thr Cys 
                85                  90                  95      


Met Val Asn Tyr Cys Glu Glu His Leu Gln Pro His Gln Val Asn Ile 
            100                 105                 110         


Lys Leu Gln Ser His Leu Leu Thr Glu Pro Val Lys Asp His Asn Trp 
        115                 120                 125             


Arg Tyr Cys Pro Ala His His Ser Pro Leu Ser Ala Phe Cys Cys Pro 
    130                 135                 140                 


Asp Gln Gln Cys Ile Cys Gln Asp Cys Cys Gln Glu His Ser Gly His 
145                 150                 155                 160 


Thr Ile Val Ser Leu Asp Ala Ala Arg Arg Asp Lys Glu Ala Glu Leu 
                165                 170                 175     


Gln Cys Thr Gln Leu Asp Leu Glu Arg Lys Leu Lys Leu Asn Glu Asn 
            180                 185                 190         


Ala Ile Ser Arg Leu Gln Ala Asn Gln Lys Ser Val Leu Val Ser Val 
        195                 200                 205             


Ser Glu Val Lys Ala Val Ala Glu Met Gln Phe Gly Glu Leu Leu Ala 
    210                 215                 220                 


Ala Val Arg Lys Ala Gln Ala Asn Val Met Leu Phe Leu Glu Glu Lys 
225                 230                 235                 240 


Glu Gln Ala Ala Leu Ser Gln Ala Asn Gly Ile Lys Ala His Leu Glu 
                245                 250                 255     


Tyr Arg Ser Ala Glu Met Glu Lys Ser Lys Gln Glu Leu Glu Arg Met 
            260                 265                 270         


Ala Ala Ile Ser Asn Thr Val Gln Phe Leu Glu Glu Tyr Cys Lys Phe 
        275                 280                 285             


Lys Asn Thr Glu Asp Ile Thr Phe Pro Ser Val Tyr Val Gly Leu Lys 
    290                 295                 300                 


Asp Lys Leu Ser Gly Ile Arg Lys Val Ile Thr Glu Ser Thr Val His 
305                 310                 315                 320 


Leu Ile Gln Leu Leu Glu Asn Tyr Lys Lys Lys Leu Gln Glu Phe Ser 
                325                 330                 335     


Lys Glu Glu Glu Tyr Asp Ile Arg Thr Gln Val Ser Ala Val Val Gln 
            340                 345                 350         


Arg Lys Tyr Trp Thr Ser Lys Pro Glu Pro Ser Thr Arg Glu Gln Phe 
        355                 360                 365             


Leu Gln Tyr Ala Tyr Asp Ile Thr Phe Asp Pro Asp Thr Ala His Lys 
    370                 375                 380                 


Tyr Leu Arg Leu Gln Glu Glu Asn Arg Lys Val Thr Asn Thr Thr Pro 
385                 390                 395                 400 


Trp Glu His Pro Tyr Pro Asp Leu Pro Ser Arg Phe Leu His Trp Arg 
                405                 410                 415     


Gln Val Leu Ser Gln Gln Ser Leu Tyr Leu His Arg Tyr Tyr Phe Glu 
            420                 425                 430         


Val Glu Ile Phe Gly Ala Gly Thr Tyr Val Gly Leu Thr Cys Lys Gly 
        435                 440                 445             


Ile Asp Arg Lys Gly Glu Glu Arg Asn Ser Cys Ile Ser Gly Asn Asn 
    450                 455                 460                 


Phe Ser Trp Ser Leu Gln Trp Asn Gly Lys Glu Phe Thr Ala Trp Tyr 
465                 470                 475                 480 


Ser Asp Met Glu Thr Pro Leu Lys Ala Gly Pro Phe Arg Arg Leu Gly 
                485                 490                 495     


Val Tyr Ile Asp Phe Pro Gly Gly Ile Leu Ser Phe Tyr Gly Val Glu 
            500                 505                 510         


Tyr Asp Thr Met Thr Leu Val His Lys Phe Ala Cys Lys Phe Ser Glu 
        515                 520                 525             


Pro Val Tyr Ala Ala Phe Trp Leu Ser Lys Lys Glu Asn Ala Ile Arg 
    530                 535                 540                 


Ile Val Asp Leu Gly Glu Glu Pro Glu Lys Pro Ala Pro Ser Leu Val 
545                 550                 555                 560 


Gly Thr Ala Pro 
                


<210>  112
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Thr Ala Ala Ser Met Gly Pro Val Arg Val Ala Phe Val Val Leu 
1               5                   10                  15      


Leu Ala Leu Cys Ser Arg Pro Ala Val Gly Gln Asn Cys Ser Gly Pro 
            20                  25                  30          


Cys Arg Cys Pro Asp Glu Pro Ala Pro Arg Cys Pro Ala Gly Val Ser 
        35                  40                  45              


Leu Val Leu Asp Gly Cys Gly Cys Cys Arg Val Cys Ala Lys Gln Leu 
    50                  55                  60                  


Gly Glu Leu Cys Thr Glu Arg Asp Pro Cys Asp Pro His Lys Gly Leu 
65                  70                  75                  80  


Phe Cys His Phe Gly Ser Pro Ala Asn Arg Lys Ile Gly Val Cys Thr 
                85                  90                  95      


Ala Lys Asp Gly Ala Pro Cys Ile Phe Gly Gly Thr Val Tyr Arg Ser 
            100                 105                 110         


Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr Gln Cys Thr Cys Leu Asp 
        115                 120                 125             


Gly Ala Val Gly Cys Met Pro Leu Cys Ser Met Asp Val Arg Leu Pro 
    130                 135                 140                 


Ser Pro Asp Cys Pro Phe Pro Arg Arg Val Lys Leu Pro Gly Lys Cys 
145                 150                 155                 160 


Cys Glu Glu Trp Val Cys Asp Glu Pro Lys Asp Gln Thr Val Val Gly 
                165                 170                 175     


Pro Ala Leu Ala Ala Tyr Arg Leu Glu Asp Thr Phe Gly Pro Asp Pro 
            180                 185                 190         


Thr Met Ile Arg Ala Asn Cys Leu Val Gln Thr Thr Glu Trp Ser Ala 
        195                 200                 205             


Cys Ser Lys Thr Cys Gly Met Gly Ile Ser Thr Arg Val Thr Asn Asp 
    210                 215                 220                 


Asn Ala Ser Cys Arg Leu Glu Lys Gln Ser Arg Leu Cys Met Val Arg 
225                 230                 235                 240 


Pro Cys Glu Ala Asp Leu Glu Glu Asn Ile Lys Lys Gly Lys Lys Cys 
                245                 250                 255     


Ile Arg Thr Pro Lys Ile Ser Lys Pro Ile Lys Phe Glu Leu Ser Gly 
            260                 265                 270         


Cys Thr Ser Met Lys Thr Tyr Arg Ala Lys Phe Cys Gly Val Cys Thr 
        275                 280                 285             


Asp Gly Arg Cys Cys Thr Pro His Arg Thr Thr Thr Leu Pro Val Glu 
    290                 295                 300                 


Phe Lys Cys Pro Asp Gly Glu Val Met Lys Lys Asn Met Met Phe Ile 
305                 310                 315                 320 


Lys Thr Cys Ala Cys His Tyr Asn Cys Pro Gly Asp Asn Asp Ile Phe 
                325                 330                 335     


Glu Ser Leu Tyr Tyr Arg Lys Met Tyr Gly Asp Met Ala 
            340                 345                 


<210>  113
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Glu Gly Ile Ser Asn Phe Lys Thr Pro Ser Lys Leu Ser Glu Lys 
1               5                   10                  15      


Lys Lys Ser Val Leu Cys Ser Thr Pro Thr Ile Asn Ile Pro Ala Ser 
            20                  25                  30          


Pro Phe Met Gln Lys Leu Gly Phe Gly Thr Gly Val Asn Val Tyr Leu 
        35                  40                  45              


Met Lys Arg Ser Pro Arg Gly Leu Ser His Ser Pro Trp Ala Val Lys 
    50                  55                  60                  


Lys Ile Asn Pro Ile Cys Asn Asp His Tyr Arg Ser Val Tyr Gln Lys 
65                  70                  75                  80  


Arg Leu Met Asp Glu Ala Lys Ile Leu Lys Ser Leu His His Pro Asn 
                85                  90                  95      


Ile Val Gly Tyr Arg Ala Phe Thr Glu Ala Asn Asp Gly Ser Leu Cys 
            100                 105                 110         


Leu Ala Met Glu Tyr Gly Gly Glu Lys Ser Leu Asn Asp Leu Ile Glu 
        115                 120                 125             


Glu Arg Tyr Lys Ala Ser Gln Asp Pro Phe Pro Ala Ala Ile Ile Leu 
    130                 135                 140                 


Lys Val Ala Leu Asn Met Ala Arg Gly Leu Lys Tyr Leu His Gln Glu 
145                 150                 155                 160 


Lys Lys Leu Leu His Gly Asp Ile Lys Ser Ser Asn Val Val Ile Lys 
                165                 170                 175     


Gly Asp Phe Glu Thr Ile Lys Ile Cys Asp Val Gly Val Ser Leu Pro 
            180                 185                 190         


Leu Asp Glu Asn Met Thr Val Thr Asp Pro Glu Ala Cys Tyr Ile Gly 
        195                 200                 205             


Thr Glu Pro Trp Lys Pro Lys Glu Ala Val Glu Glu Asn Gly Val Ile 
    210                 215                 220                 


Thr Asp Lys Ala Asp Ile Phe Ala Phe Gly Leu Thr Leu Trp Glu Met 
225                 230                 235                 240 


Met Thr Leu Ser Ile Pro His Ile Asn Leu Ser Asn Asp Asp Asp Asp 
                245                 250                 255     


Glu Asp Lys Thr Phe Asp Glu Ser Asp Phe Asp Asp Glu Ala Tyr Tyr 
            260                 265                 270         


Ala Ala Leu Gly Thr Arg Pro Pro Ile Asn Met Glu Glu Leu Asp Glu 
        275                 280                 285             


Ser Tyr Gln Lys Val Ile Glu Leu Phe Ser Val Cys Thr Asn Glu Asp 
    290                 295                 300                 


Pro Lys Asp Arg Pro Ser Ala Ala His Ile Val Glu Ala Leu Glu Thr 
305                 310                 315                 320 


Asp Val 
        


<210>  114
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Arg Thr Ser Gly Arg Arg Trp Ala Val Leu Gly Ser Pro His Val 
1               5                   10                  15      


Cys Arg Gly Val Val Arg Thr Arg Gly Ala Pro Gly Leu Trp Gly Thr 
            20                  25                  30          


Ser Phe Asn Pro Arg Ser Leu Ala Leu Pro Ala Asp Arg Trp Phe Leu 
        35                  40                  45              


Glu Phe Glu Lys Val Pro Leu Phe Met Ser Arg Ala Pro Ser Glu Ile 
    50                  55                  60                  


Asp Pro Arg Glu Asn Pro Asp Leu Ala Cys Leu Gln Ser Ile Ile Phe 
65                  70                  75                  80  


Asp Glu Glu Arg Ser Pro Glu Glu Gln Ala Lys Thr Tyr Lys Asp Glu 
                85                  90                  95      


Gly Asn Asp Tyr Phe Lys Glu Lys Asp Tyr Lys Lys Ala Val Ile Ser 
            100                 105                 110         


Tyr Thr Glu Gly Leu Lys Lys Lys Cys Ala Asp Pro Asp Leu Asn Ala 
        115                 120                 125             


Val Leu Tyr Thr Asn Arg Ala Ala Ala Gln Tyr Tyr Leu Gly Asn Phe 
    130                 135                 140                 


Arg Ser Ala Leu Asn Asp Val Thr Ala Ala Arg Lys Leu Lys Pro Cys 
145                 150                 155                 160 


His Leu Lys Ala Ile Ile Arg Gly Ala Leu Cys His Leu Glu Leu Lys 
                165                 170                 175     


His Phe Ala Glu Ala Val Asn Trp Cys Asp Glu Gly Leu Gln Ile Asp 
            180                 185                 190         


Ala Lys Glu Lys Lys Leu Leu Glu Met Arg Ala Lys Ala Asp Lys Leu 
        195                 200                 205             


Lys Arg Ile Glu Gln Arg Asp Val Arg Lys Ala Asn Leu Lys Glu Lys 
    210                 215                 220                 


Lys Glu Arg Asn Gln Asn Glu Ala Leu Leu Gln Ala Ile Lys Ala Arg 
225                 230                 235                 240 


Asn Ile Arg Leu Ser Glu Ala Ala Cys Glu Asp Glu Asp Ser Ala Ser 
                245                 250                 255     


Glu Gly Leu Gly Glu Leu Phe Leu Asp Gly Leu Ser Thr Glu Asn Pro 
            260                 265                 270         


His Gly Ala Arg Leu Ser Leu Asp Gly Gln Gly Arg Leu Ser Trp Pro 
        275                 280                 285             


Val Leu Phe Leu Tyr Pro Glu Tyr Ala Gln Ser Asp Phe Ile Ser Ala 
    290                 295                 300                 


Phe His Glu Asp Ser Arg Phe Ile Asp His Leu Met Val Met Phe Gly 
305                 310                 315                 320 


Glu Thr Pro Ser Trp Asp Leu Glu Gln Lys Tyr Cys Pro Asp Asn Leu 
                325                 330                 335     


Glu Val Tyr Phe Glu Asp Glu Asp Arg Ala Glu Leu Tyr Arg Val Pro 
            340                 345                 350         


Ala Lys Ser Thr Leu Leu Gln Val Leu Gln His Gln Arg Tyr Phe Val 
        355                 360                 365             


Lys Ala Leu Thr Pro Ala Phe Leu Val Cys Val Gly Ser Ser Pro Phe 
    370                 375                 380                 


Cys Lys Asn Phe Leu Arg Gly Arg Lys Val Tyr Gln Ile Arg 
385                 390                 395             


<210>  115
<211>  870
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Asn His Leu Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn Val Ala 
1               5                   10                  15      


Glu Ser Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met Thr Val 
            20                  25                  30          


Leu Glu Gln Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu Cys Ser Leu 
        35                  40                  45              


His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile Leu Val 
    50                  55                  60                  


Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly Pro Pro Ala 
65                  70                  75                  80  


Thr Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala Pro Pro Ala 
                85                  90                  95      


Ser Gln Tyr Thr Pro Met Leu Pro Asn Thr Tyr Gln Pro Gln Pro Asp 
            100                 105                 110         


Ser Val Tyr Leu Val Pro Thr Pro Ser Lys Ala Gln Gln Gly Leu Tyr 
        115                 120                 125             


Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro Ala Lys Gln 
    130                 135                 140                 


Thr Ser Thr Phe Ser Lys Gln Thr Pro His His Pro Phe Pro Ser Pro 
145                 150                 155                 160 


Ala Thr Asp Leu Tyr Gln Val Pro Pro Gly Pro Gly Gly Pro Ala Gln 
                165                 170                 175     


Asp Ile Tyr Gln Val Pro Pro Ser Ala Gly Met Gly His Asp Ile Tyr 
            180                 185                 190         


Gln Val Pro Pro Ser Met Asp Thr Arg Ser Trp Glu Gly Thr Lys Pro 
        195                 200                 205             


Pro Ala Lys Val Val Val Pro Thr Arg Val Gly Gln Gly Tyr Val Tyr 
    210                 215                 220                 


Glu Ala Ala Gln Pro Glu Gln Asp Glu Tyr Asp Ile Pro Arg His Leu 
225                 230                 235                 240 


Leu Ala Pro Gly Pro Gln Asp Ile Tyr Asp Val Pro Pro Val Arg Gly 
                245                 250                 255     


Leu Leu Pro Ser Gln Tyr Gly Gln Glu Val Tyr Asp Thr Pro Pro Met 
            260                 265                 270         


Ala Val Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Glu Val Tyr Asp 
        275                 280                 285             


Val Pro Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His His Ala 
    290                 295                 300                 


Val Tyr Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp Gly Pro 
305                 310                 315                 320 


Leu Leu Arg Glu Glu Thr Tyr Asp Val Pro Pro Ala Phe Ala Lys Ala 
                325                 330                 335     


Lys Pro Phe Asp Pro Ala Arg Thr Pro Leu Val Leu Ala Ala Pro Pro 
            340                 345                 350         


Pro Asp Ser Pro Pro Ala Glu Asp Val Tyr Asp Val Pro Pro Pro Ala 
        355                 360                 365             


Pro Asp Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly Pro Gly 
    370                 375                 380                 


Thr Leu Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu Val Ala 
385                 390                 395                 400 


Asp Gly Gly Val Val Asp Ser Gly Val Tyr Ala Val Pro Pro Pro Ala 
                405                 410                 415     


Glu Arg Glu Ala Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser Ser Thr 
            420                 425                 430         


Gly Ser Thr Arg Ser Ser Gln Ser Ala Ser Ser Leu Glu Val Ala Gly 
        435                 440                 445             


Pro Gly Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Ala Leu Ala 
    450                 455                 460                 


Arg Leu Gln Gln Gly Val Ser Ala Thr Val Ala His Leu Leu Asp Leu 
465                 470                 475                 480 


Ala Gly Ser Ala Gly Ala Thr Gly Ser Trp Arg Ser Pro Ser Glu Pro 
                485                 490                 495     


Gln Glu Pro Leu Val Gln Asp Leu Gln Ala Ala Val Ala Ala Val Gln 
            500                 505                 510         


Ser Ala Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val Gly Asn 
        515                 520                 525             


Ala Ala His Thr Ser Asp Arg Ala Leu His Ala Lys Leu Ser Arg Gln 
    530                 535                 540                 


Leu Gln Lys Met Glu Asp Val His Gln Thr Leu Val Ala His Gly Gln 
545                 550                 555                 560 


Ala Leu Asp Ala Gly Arg Gly Gly Ser Gly Ala Thr Leu Glu Asp Leu 
                565                 570                 575     


Asp Arg Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala Lys Gln 
            580                 585                 590         


Leu Ala Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg Arg Thr 
        595                 600                 605             


Lys Ala Thr Ala Pro Gly Pro Glu Gly Gly Gly Thr Leu His Pro Asn 
    610                 615                 620                 


Pro Thr Asp Lys Thr Ser Ser Ile Gln Ser Arg Pro Leu Pro Ser Pro 
625                 630                 635                 640 


Pro Lys Phe Thr Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu Asn Ser 
                645                 650                 655     


Glu Gly Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gln Gly Lys 
            660                 665                 670         


Glu Glu Phe Glu Lys Thr Gln Lys Glu Leu Leu Glu Lys Gly Ser Ile 
        675                 680                 685             


Thr Arg Gln Gly Lys Ser Gln Leu Glu Leu Gln Gln Leu Lys Gln Phe 
    690                 695                 700                 


Glu Arg Leu Glu Gln Glu Val Ser Arg Pro Ile Asp His Asp Leu Ala 
705                 710                 715                 720 


Asn Trp Thr Pro Ala Gln Pro Leu Ala Pro Gly Arg Thr Gly Gly Leu 
                725                 730                 735     


Gly Pro Ser Asp Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln Cys Glu 
            740                 745                 750         


Ala Asn Leu Thr Thr Leu Thr Asn Ala Val Asp Ala Phe Phe Thr Ala 
        755                 760                 765             


Val Ala Thr Asn Gln Pro Pro Lys Ile Phe Val Ala His Ser Lys Phe 
    770                 775                 780                 


Val Ile Leu Ser Ala His Lys Leu Val Phe Ile Gly Asp Thr Leu Ser 
785                 790                 795                 800 


Arg Gln Ala Lys Ala Ala Asp Val Arg Ser Gln Val Thr His Tyr Ser 
                805                 810                 815     


Asn Leu Leu Cys Asp Leu Leu Arg Gly Ile Val Ala Thr Thr Lys Ala 
            820                 825                 830         


Ala Ala Leu Gln Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met Val Glu 
        835                 840                 845             


Arg Val Lys Glu Leu Gly His Ser Thr Gln Gln Phe Arg Arg Val Leu 
    850                 855                 860                 


Gly Gln Leu Ala Ala Ala 
865                 870 


<210>  116
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Leu Ser Leu Arg Val Pro Leu Ala Pro Ile Thr Asp Pro Gln Gln 
1               5                   10                  15      


Leu Gln Leu Ser Pro Leu Lys Gly Leu Ser Leu Val Asp Lys Glu Asn 
            20                  25                  30          


Thr Pro Pro Ala Leu Ser Gly Thr Arg Val Leu Ala Ser Lys Thr Ala 
        35                  40                  45              


Arg Arg Ile Phe Gln Glu Pro Thr Glu Pro Lys Thr Lys Ala Ala Ala 
    50                  55                  60                  


Pro Gly Val Glu Asp Glu Pro Leu Leu Arg Glu Asn Pro Arg Arg Phe 
65                  70                  75                  80  


Val Ile Phe Pro Ile Glu Tyr His Asp Ile Trp Gln Met Tyr Lys Lys 
                85                  90                  95      


Ala Glu Ala Ser Phe Trp Thr Ala Glu Glu Val Asp Leu Ser Lys Asp 
            100                 105                 110         


Ile Gln His Trp Glu Ser Leu Lys Pro Glu Glu Arg Tyr Phe Ile Ser 
        115                 120                 125             


His Val Leu Ala Phe Phe Ala Ala Ser Asp Gly Ile Val Asn Glu Asn 
    130                 135                 140                 


Leu Val Glu Arg Phe Ser Gln Glu Val Gln Ile Thr Glu Ala Arg Cys 
145                 150                 155                 160 


Phe Tyr Gly Phe Gln Ile Ala Met Glu Asn Ile His Ser Glu Met Tyr 
                165                 170                 175     


Ser Leu Leu Ile Asp Thr Tyr Ile Lys Asp Pro Lys Glu Arg Glu Phe 
            180                 185                 190         


Leu Phe Asn Ala Ile Glu Thr Met Pro Cys Val Lys Lys Lys Ala Asp 
        195                 200                 205             


Trp Ala Leu Arg Trp Ile Gly Asp Lys Glu Ala Thr Tyr Gly Glu Arg 
    210                 215                 220                 


Val Val Ala Phe Ala Ala Val Glu Gly Ile Phe Phe Ser Gly Ser Phe 
225                 230                 235                 240 


Ala Ser Ile Phe Trp Leu Lys Lys Arg Gly Leu Met Pro Gly Leu Thr 
                245                 250                 255     


Phe Ser Asn Glu Leu Ile Ser Arg Asp Glu Gly Leu His Cys Asp Phe 
            260                 265                 270         


Ala Cys Leu Met Phe Lys His Leu Val His Lys Pro Ser Glu Glu Arg 
        275                 280                 285             


Val Arg Glu Ile Ile Ile Asn Ala Val Arg Ile Glu Gln Glu Phe Leu 
    290                 295                 300                 


Thr Glu Ala Leu Pro Val Lys Leu Ile Gly Met Asn Cys Thr Leu Met 
305                 310                 315                 320 


Lys Gln Tyr Ile Glu Phe Val Ala Asp Arg Leu Met Leu Glu Leu Gly 
                325                 330                 335     


Phe Ser Lys Val Phe Arg Val Glu Asn Pro Phe Asp Phe Met Glu Asn 
            340                 345                 350         


Ile Ser Leu Glu Gly Lys Thr Asn Phe Phe Glu Lys Arg Val Gly Glu 
        355                 360                 365             


Tyr Gln Arg Met Gly Val Met Ser Ser Pro Thr Glu Asn Ser Phe Thr 
    370                 375                 380                 


Leu Asp Ala Asp Phe 
385                 


<210>  117
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Ala Ser Gln Asn Arg Asp Pro Ala Ala Thr Ser Val Ala Ala Ala 
1               5                   10                  15      


Arg Lys Gly Ala Glu Pro Ser Gly Gly Ala Ala Arg Gly Pro Val Gly 
            20                  25                  30          


Lys Arg Leu Gln Gln Glu Leu Met Thr Leu Met Met Ser Gly Asp Lys 
        35                  40                  45              


Gly Ile Ser Ala Phe Pro Glu Ser Asp Asn Leu Phe Lys Trp Val Gly 
    50                  55                  60                  


Thr Ile His Gly Ala Ala Gly Thr Val Tyr Glu Asp Leu Arg Tyr Lys 
65                  70                  75                  80  


Leu Ser Leu Glu Phe Pro Ser Gly Tyr Pro Tyr Asn Ala Pro Thr Val 
                85                  90                  95      


Lys Phe Leu Thr Pro Cys Tyr His Pro Asn Val Asp Thr Gln Gly Asn 
            100                 105                 110         


Ile Cys Leu Asp Ile Leu Lys Glu Lys Trp Ser Ala Leu Tyr Asp Val 
        115                 120                 125             


Arg Thr Ile Leu Leu Ser Ile Gln Ser Leu Leu Gly Glu Pro Asn Ile 
    130                 135                 140                 


Asp Ser Pro Leu Asn Thr His Ala Ala Glu Leu Trp Lys Asn Pro Thr 
145                 150                 155                 160 


Ala Phe Lys Lys Tyr Leu Gln Glu Thr Tyr Ser Lys Gln Val Thr Ser 
                165                 170                 175     


Gln Glu Pro 
            


<210>  118
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Arg Thr Leu Ala Ile Leu Ala Ala Ile Leu Leu Val Ala Leu Gln 
1               5                   10                  15      


Ala Gln Ala Glu Pro Leu Gln Ala Arg Ala Asp Glu Val Ala Ala Ala 
            20                  25                  30          


Pro Glu Gln Ile Ala Ala Asp Ile Pro Glu Val Val Val Ser Leu Ala 
        35                  40                  45              


Trp Asp Glu Ser Leu Ala Pro Lys His Pro Gly Ser Arg Lys Asn Met 
    50                  55                  60                  


Ala Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
65                  70                  75                  80  


Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
                85                  90                  


<210>  119
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Pro Ala Lys Thr Pro Ile Tyr Leu Lys Ala Ala Asn Asn Lys Lys 
1               5                   10                  15      


Gly Lys Lys Phe Lys Leu Arg Asp Ile Leu Ser Pro Asp Met Ile Ser 
            20                  25                  30          


Pro Pro Leu Gly Asp Phe Arg His Thr Ile His Ile Gly Lys Glu Gly 
        35                  40                  45              


Gln His Asp Val Phe Gly Asp Ile Ser Phe Leu Gln Gly Asn Tyr Glu 
    50                  55                  60                  


Leu Leu Pro Gly Asn Gln Glu Lys Ala His Leu Gly Gln Phe Pro Gly 
65                  70                  75                  80  


His Asn Glu Phe Phe Arg Ala Asn Ser Thr Ser Asp Ser Val Phe Thr 
                85                  90                  95      


Glu Thr Pro Ser Pro Val Leu Lys Asn Ala Ile Ser Leu Pro Thr Ile 
            100                 105                 110         


Gly Gly Ser Gln Ala Leu Met Leu Pro Leu Leu Ser Pro Val Thr Phe 
        115                 120                 125             


Asn Ser Lys Gln Glu Ser Phe Gly Pro Ala Lys Leu Pro Arg Leu Ser 
    130                 135                 140                 


Cys Glu Pro Val Met Glu Glu Lys Ala Gln Glu Lys Ser Ser Leu Leu 
145                 150                 155                 160 


Glu Asn Gly Thr Val His Gln Gly Asp Thr Ser Trp Gly Ser Ser Gly 
                165                 170                 175     


Ser Ala Ser Gln Ser Ser Gln Gly Arg Asp Ser His Ser Ser Ser Leu 
            180                 185                 190         


Ser Glu Gln Tyr Pro Asp Trp Pro Ala Glu Asp Met Phe Asp His Pro 
        195                 200                 205             


Thr Pro Cys Glu Leu Ile Lys Gly Lys Thr Lys Ser Glu Glu Ser Leu 
    210                 215                 220                 


Ser Asp Leu Thr Gly Ser Leu Leu Ser Leu Gln Leu Asp Leu Gly Pro 
225                 230                 235                 240 


Ser Leu Leu Asp Glu Val Leu Asn Val Met Asp Lys Asn Lys 
                245                 250                 


<210>  120
<211>  741
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Gly Pro Pro Gly Pro Ala Leu Pro Ala Thr Met Asn Asn Ser Ser 
1               5                   10                  15      


Ser Glu Thr Arg Gly His Pro His Ser Ala Ser Ser Pro Ser Glu Arg 
            20                  25                  30          


Val Phe Pro Met Pro Leu Pro Arg Lys Ala Pro Leu Asn Ile Pro Gly 
        35                  40                  45              


Thr Pro Val Leu Glu Asp Phe Pro Gln Asn Asp Asp Glu Lys Glu Arg 
    50                  55                  60                  


Leu Gln Arg Arg Arg Ser Arg Val Phe Asp Leu Gln Phe Ser Thr Asp 
65                  70                  75                  80  


Ser Pro Arg Leu Leu Ala Ser Pro Ser Ser Arg Ser Ile Asp Ile Ser 
                85                  90                  95      


Ala Thr Ile Pro Lys Phe Thr Asn Thr Gln Ile Thr Glu His Tyr Ser 
            100                 105                 110         


Thr Cys Ile Lys Leu Ser Thr Glu Asn Lys Ile Thr Thr Lys Asn Ala 
        115                 120                 125             


Phe Gly Leu His Leu Ile Asp Phe Met Ser Glu Ile Leu Lys Gln Lys 
    130                 135                 140                 


Asp Thr Glu Pro Thr Asn Phe Lys Val Ala Ala Gly Thr Leu Asp Ala 
145                 150                 155                 160 


Ser Thr Lys Ile Tyr Ala Val Arg Val Asp Ala Val His Ala Asp Val 
                165                 170                 175     


Tyr Arg Val Leu Gly Gly Leu Gly Lys Asp Ala Pro Ser Leu Glu Glu 
            180                 185                 190         


Val Glu Gly His Val Ala Asp Gly Ser Ala Thr Glu Met Gly Thr Thr 
        195                 200                 205             


Lys Lys Ala Val Lys Pro Lys Lys Lys His Leu His Arg Thr Ile Glu 
    210                 215                 220                 


Gln Asn Ile Asn Asn Leu Asn Val Ser Glu Ala Asp Arg Lys Cys Glu 
225                 230                 235                 240 


Ile Asp Pro Met Phe Gln Lys Thr Ala Ala Ser Phe Asp Glu Cys Ser 
                245                 250                 255     


Thr Ala Gly Val Phe Leu Ser Thr Leu His Cys Gln Asp Tyr Arg Ser 
            260                 265                 270         


Glu Leu Leu Phe Pro Ser Asp Val Gln Thr Leu Ser Thr Gly Glu Pro 
        275                 280                 285             


Leu Glu Leu Pro Glu Leu Gly Cys Val Glu Met Thr Asp Leu Lys Ala 
    290                 295                 300                 


Pro Leu Gln Gln Cys Ala Glu Asp Arg Gln Ile Cys Pro Ser Leu Ala 
305                 310                 315                 320 


Gly Phe Gln Phe Thr Gln Trp Asp Ser Glu Thr His Asn Glu Ser Val 
                325                 330                 335     


Ser Ala Leu Val Asp Lys Phe Lys Lys Asn Asp Gln Val Phe Asp Ile 
            340                 345                 350         


Asn Ala Glu Val Asp Glu Ser Asp Cys Gly Asp Phe Pro Asp Gly Ser 
        355                 360                 365             


Leu Gly Asp Asp Phe Asp Ala Asn Asp Glu Pro Asp His Thr Ala Val 
    370                 375                 380                 


Gly Asp His Glu Glu Phe Arg Ser Trp Lys Glu Pro Cys Gln Val Gln 
385                 390                 395                 400 


Ser Cys Gln Glu Glu Met Ile Ser Leu Gly Asp Gly Asp Ile Arg Thr 
                405                 410                 415     


Met Cys Pro Leu Leu Ser Met Lys Pro Gly Glu Tyr Ser Tyr Phe Ser 
            420                 425                 430         


Pro Arg Thr Met Ser Met Trp Ala Gly Pro Asp His Trp Arg Phe Arg 
        435                 440                 445             


Pro Arg Arg Lys Gln Asp Ala Pro Ser Gln Ser Glu Asn Lys Lys Lys 
    450                 455                 460                 


Ser Thr Lys Lys Asp Phe Glu Ile Asp Phe Glu Asp Asp Ile Asp Phe 
465                 470                 475                 480 


Asp Val Tyr Phe Arg Lys Thr Lys Ala Ala Thr Ile Leu Thr Lys Ser 
                485                 490                 495     


Thr Leu Glu Asn Gln Asn Trp Arg Ala Thr Thr Leu Pro Thr Asp Phe 
            500                 505                 510         


Asn Tyr Asn Val Asp Thr Leu Val Gln Leu His Leu Lys Pro Gly Thr 
        515                 520                 525             


Arg Leu Leu Lys Met Ala Gln Gly His Arg Val Glu Thr Glu His Tyr 
    530                 535                 540                 


Glu Glu Ile Glu Asp Tyr Asp Tyr Asn Asn Pro Asn Asp Thr Ser Asn 
545                 550                 555                 560 


Phe Cys Pro Gly Leu Gln Ala Ala Asp Ser Asp Asp Glu Asp Leu Asp 
                565                 570                 575     


Asp Leu Phe Val Gly Pro Val Gly Asn Ser Asp Leu Ser Pro Tyr Pro 
            580                 585                 590         


Cys His Pro Pro Lys Thr Ala Gln Gln Asn Gly Asp Thr Pro Glu Ala 
        595                 600                 605             


Gln Gly Leu Asp Ile Thr Thr Tyr Gly Glu Ser Asn Leu Val Ala Glu 
    610                 615                 620                 


Pro Gln Lys Val Asn Lys Ile Glu Ile His Tyr Ala Lys Thr Ala Lys 
625                 630                 635                 640 


Lys Met Asp Met Lys Lys Leu Lys Gln Ser Met Trp Ser Leu Leu Thr 
                645                 650                 655     


Ala Leu Ser Gly Lys Glu Ala Asp Ala Glu Ala Asn His Arg Glu Ala 
            660                 665                 670         


Gly Lys Glu Ala Ala Leu Ala Glu Val Ala Asp Glu Lys Met Leu Ser 
        675                 680                 685             


Gly Leu Thr Lys Asp Leu Gln Arg Ser Leu Pro Pro Val Met Ala Gln 
    690                 695                 700                 


Asn Leu Ser Ile Pro Leu Ala Phe Ala Cys Leu Leu His Leu Ala Asn 
705                 710                 715                 720 


Glu Lys Asn Leu Lys Leu Glu Gly Thr Glu Asp Leu Ser Asp Val Leu 
                725                 730                 735     


Val Arg Gln Gly Asp 
            740     


<210>  121
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  121

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  122
<211>  1015
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Gly Ala Glu Arg Arg Leu Leu Ser Ile Lys Glu Ala Phe Arg Leu 
1               5                   10                  15      


Ala Gln Gln Pro His Gln Asn Gln Ala Lys Leu Val Val Ala Leu Ser 
            20                  25                  30          


Arg Thr Tyr Arg Thr Met Asp Asp Lys Thr Val Phe His Glu Glu Phe 
        35                  40                  45              


Ile His Tyr Leu Lys Tyr Val Met Val Val Tyr Lys Arg Glu Pro Ala 
    50                  55                  60                  


Val Glu Arg Val Ile Glu Phe Ala Ala Lys Phe Val Thr Ser Phe His 
65                  70                  75                  80  


Gln Ser Asp Met Glu Asp Asp Glu Glu Glu Glu Asp Gly Gly Leu Leu 
                85                  90                  95      


Asn Tyr Leu Phe Thr Phe Leu Leu Lys Ser His Glu Ala Asn Ser Asn 
            100                 105                 110         


Ala Val Arg Phe Arg Val Cys Leu Leu Ile Asn Lys Leu Leu Gly Ser 
        115                 120                 125             


Met Pro Glu Asn Ala Gln Ile Asp Asp Asp Val Phe Asp Lys Ile Asn 
    130                 135                 140                 


Lys Ala Met Leu Ile Arg Leu Lys Asp Lys Ile Pro Asn Val Arg Ile 
145                 150                 155                 160 


Gln Ala Val Leu Ala Leu Ser Arg Leu Gln Asp Pro Lys Asp Asp Glu 
                165                 170                 175     


Cys Pro Val Val Asn Ala Tyr Ala Thr Leu Ile Glu Asn Asp Ser Asn 
            180                 185                 190         


Pro Glu Val Arg Arg Ala Val Leu Ser Cys Ile Ala Pro Ser Ala Lys 
        195                 200                 205             


Thr Leu Pro Lys Ile Val Gly Arg Thr Lys Asp Val Lys Glu Ala Val 
    210                 215                 220                 


Arg Lys Leu Ala Tyr Gln Val Leu Ala Glu Lys Val His Met Arg Ala 
225                 230                 235                 240 


Met Ser Ile Ala Gln Arg Val Met Leu Leu Gln Gln Gly Leu Asn Asp 
                245                 250                 255     


Arg Ser Asp Ala Val Lys Gln Ala Met Gln Lys His Leu Leu Gln Gly 
            260                 265                 270         


Trp Leu Arg Phe Ser Glu Gly Asn Ile Leu Glu Leu Leu His Arg Leu 
        275                 280                 285             


Asp Val Glu Asn Ser Ser Glu Val Ala Val Ser Val Leu Asn Ala Leu 
    290                 295                 300                 


Phe Ser Ile Thr Pro Leu Ser Glu Leu Val Gly Leu Cys Lys Asn Asn 
305                 310                 315                 320 


Asp Gly Arg Lys Leu Ile Pro Val Glu Thr Leu Thr Pro Glu Ile Ala 
                325                 330                 335     


Leu Tyr Trp Cys Ala Leu Cys Glu Tyr Leu Lys Ser Lys Gly Asp Glu 
            340                 345                 350         


Gly Glu Glu Phe Leu Glu Gln Ile Leu Pro Glu Pro Val Val Tyr Ala 
        355                 360                 365             


Asp Tyr Leu Leu Ser Tyr Ile Gln Ser Ile Pro Val Val Asn Glu Glu 
    370                 375                 380                 


His Arg Gly Asp Phe Ser Tyr Ile Gly Asn Leu Met Thr Lys Glu Phe 
385                 390                 395                 400 


Ile Gly Gln Gln Leu Ile Leu Ile Ile Lys Ser Leu Asp Thr Ser Glu 
                405                 410                 415     


Glu Gly Gly Arg Lys Lys Leu Leu Ala Val Leu Gln Glu Ile Leu Ile 
            420                 425                 430         


Leu Pro Thr Ile Pro Ile Ser Leu Val Ser Phe Leu Val Glu Arg Leu 
        435                 440                 445             


Leu His Ile Ile Ile Asp Asp Asn Lys Arg Thr Gln Ile Val Thr Glu 
    450                 455                 460                 


Ile Ile Ser Glu Ile Arg Ala Pro Ile Val Thr Val Gly Val Asn Asn 
465                 470                 475                 480 


Asp Pro Ala Asp Val Arg Lys Lys Glu Leu Lys Met Ala Glu Ile Lys 
                485                 490                 495     


Val Lys Leu Ile Glu Ala Lys Glu Ala Leu Glu Asn Cys Ile Thr Leu 
            500                 505                 510         


Gln Asp Phe Asn Arg Ala Ser Glu Leu Lys Glu Glu Ile Lys Ala Leu 
        515                 520                 525             


Glu Asp Ala Arg Ile Asn Leu Leu Lys Glu Thr Glu Gln Leu Glu Ile 
    530                 535                 540                 


Lys Glu Val His Ile Glu Lys Asn Asp Ala Glu Thr Leu Gln Lys Cys 
545                 550                 555                 560 


Leu Ile Leu Cys Tyr Glu Leu Leu Lys Gln Met Ser Ile Ser Thr Gly 
                565                 570                 575     


Leu Ser Ala Thr Met Asn Gly Ile Ile Glu Ser Leu Ile Leu Pro Gly 
            580                 585                 590         


Ile Ile Ser Ile His Pro Val Val Arg Asn Leu Ala Val Leu Cys Leu 
        595                 600                 605             


Gly Cys Cys Gly Leu Gln Asn Gln Asp Phe Ala Arg Lys His Phe Val 
    610                 615                 620                 


Leu Leu Leu Gln Val Leu Gln Ile Asp Asp Val Thr Ile Lys Ile Ser 
625                 630                 635                 640 


Ala Leu Lys Ala Ile Phe Asp Gln Leu Met Thr Phe Gly Ile Glu Pro 
                645                 650                 655     


Phe Lys Thr Lys Lys Ile Lys Thr Leu His Cys Glu Gly Thr Glu Ile 
            660                 665                 670         


Asn Ser Asp Asp Glu Gln Glu Ser Lys Glu Val Glu Glu Thr Ala Thr 
        675                 680                 685             


Ala Lys Asn Val Leu Lys Leu Leu Ser Asp Phe Leu Asp Ser Glu Val 
    690                 695                 700                 


Ser Glu Leu Arg Thr Gly Ala Ala Glu Gly Leu Ala Lys Leu Met Phe 
705                 710                 715                 720 


Ser Gly Leu Leu Val Ser Ser Arg Ile Leu Ser Arg Leu Ile Leu Leu 
                725                 730                 735     


Trp Tyr Asn Pro Val Thr Glu Glu Asp Val Gln Leu Arg His Cys Leu 
            740                 745                 750         


Gly Val Phe Phe Pro Val Phe Ala Tyr Ala Ser Arg Thr Asn Gln Glu 
        755                 760                 765             


Cys Phe Glu Glu Ala Phe Leu Pro Thr Leu Gln Thr Leu Ala Asn Ala 
    770                 775                 780                 


Pro Ala Ser Ser Pro Leu Ala Glu Ile Asp Ile Thr Asn Val Ala Glu 
785                 790                 795                 800 


Leu Leu Val Asp Leu Thr Arg Pro Ser Gly Leu Asn Pro Gln Ala Lys 
                805                 810                 815     


Thr Ser Gln Asp Tyr Gln Ala Leu Thr Val His Asp Asn Leu Ala Met 
            820                 825                 830         


Lys Ile Cys Asn Glu Ile Leu Thr Ser Pro Cys Ser Pro Glu Ile Arg 
        835                 840                 845             


Val Tyr Thr Lys Ala Leu Ser Ser Leu Glu Leu Ser Ser His Leu Ala 
    850                 855                 860                 


Lys Asp Leu Leu Val Leu Leu Asn Glu Ile Leu Glu Gln Val Lys Asp 
865                 870                 875                 880 


Arg Thr Cys Leu Arg Ala Leu Glu Lys Ile Lys Ile Gln Leu Glu Lys 
                885                 890                 895     


Gly Asn Lys Glu Phe Gly Asp Gln Ala Glu Ala Ala Gln Asp Ala Thr 
            900                 905                 910         


Leu Thr Thr Thr Thr Phe Gln Asn Glu Asp Glu Lys Asn Lys Glu Val 
        915                 920                 925             


Tyr Met Thr Pro Leu Arg Gly Val Lys Ala Thr Gln Ala Ser Lys Ser 
    930                 935                 940                 


Thr Gln Leu Lys Thr Asn Arg Gly Gln Arg Lys Val Thr Val Ser Ala 
945                 950                 955                 960 


Arg Thr Asn Arg Arg Cys Gln Thr Ala Glu Ala Asp Ser Glu Ser Asp 
                965                 970                 975     


His Glu Val Pro Glu Pro Glu Ser Glu Met Lys Met Arg Leu Pro Arg 
            980                 985                 990         


Arg Ala Lys Thr Ala Ala Leu Glu  Lys Ser Lys Leu Asn  Leu Ala Gln 
        995                 1000                 1005             


Phe Leu  Asn Glu Asp Leu Ser  
    1010                 1015 


<210>  123
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Ala Ser Pro Glu Pro Arg Arg Gly Gly Asp Gly Ala Ala Gln Ala 
1               5                   10                  15      


Ala Arg Lys Thr Arg Val Glu Ala Asn Ser Pro Leu Pro Lys Asn Ser 
            20                  25                  30          


Gly Ser Leu Asn Glu Ala Glu Ala Leu Asn Pro Glu Val Thr Leu Ser 
        35                  40                  45              


Ser Glu Gly Ser Leu Asn Leu Glu Asp Ile Leu Tyr Leu Glu Asp Thr 
    50                  55                  60                  


Gly Asp Leu Asp Glu Thr Leu Tyr Val Gln Glu Thr Glu Lys Ala Glu 
65                  70                  75                  80  


Glu Ala Leu Tyr Ile Glu Glu Ala Met Gln Pro Asp Glu Ala Leu His 
                85                  90                  95      


Val Glu Glu Pro Gly Asn Pro Glu Glu Thr Val Cys Val Glu Glu Thr 
            100                 105                 110         


Thr Glu Pro Asp Arg Ile Gln Phe Val Glu Gly Pro Val Glu Pro Gly 
        115                 120                 125             


Lys Pro Thr Ser Pro Glu His Val Val Tyr Glu Gly Glu Thr Val Thr 
    130                 135                 140                 


Arg Ala Glu Lys Ser Asn Pro Glu Glu Ser Leu Arg Ala Glu Gln Ser 
145                 150                 155                 160 


Pro Ser Met Glu Glu Asn Leu Ser Ile Glu Asp Leu Glu Leu Leu Glu 
                165                 170                 175     


Gly Arg Phe Gln Gln Cys Val Gln Ala Val Ala Gln Leu Glu Glu Glu 
            180                 185                 190         


Arg Asp Gln Leu Ile His Glu Leu Val Leu Leu Arg Glu Pro Ala Leu 
        195                 200                 205             


Gln Glu Val Gln Gln Val His Gln Asp Ile Leu Ala Ala Tyr Lys Leu 
    210                 215                 220                 


His Ala Gln Ala Glu Leu Glu Arg Asp Gly Leu Arg Glu Glu Ile Arg 
225                 230                 235                 240 


Leu Val Lys Gln Lys Leu Phe Lys Val Thr Lys Glu Cys Val Ala Tyr 
                245                 250                 255     


Gln Tyr Gln Leu Glu Cys Arg Gln Gln Asp Val Ala Gln Phe Ala Asp 
            260                 265                 270         


Phe Arg Glu Val Leu Thr Thr Arg Ala Thr Gln Leu Ser Glu Glu Leu 
        275                 280                 285             


Ala Gln Leu Arg Asp Ala Tyr Gln Lys Gln Lys Glu Gln Leu Arg Gln 
    290                 295                 300                 


Gln Leu Glu Ala Pro Pro Ser Gln Arg Asp Gly His Phe Leu Gln Glu 
305                 310                 315                 320 


Ser Arg Arg Leu Ser Ala Gln Phe Glu Asn Leu Met Ala Glu Ser Arg 
                325                 330                 335     


Gln Asp Leu Glu Glu Glu Tyr Glu Pro Gln Phe Leu Arg Leu Leu Glu 
            340                 345                 350         


Arg Lys Glu Ala Gly Thr Lys Ala Leu Gln Arg Thr Gln Ala Glu Ile 
        355                 360                 365             


Gln Glu Met Lys Glu Ala Leu Arg Pro Leu Gln Ala Glu Ala Arg Gln 
    370                 375                 380                 


Leu Arg Leu Gln Asn Arg Asn Leu Glu Asp Gln Ile Ala Leu Val Arg 
385                 390                 395                 400 


Gln Lys Arg Asp Glu Glu Val Gln Gln Tyr Arg Glu Gln Leu Glu Glu 
                405                 410                 415     


Met Glu Glu Arg Gln Arg Gln Leu Arg Asn Gly Val Gln Leu Gln Gln 
            420                 425                 430         


Gln Lys Asn Lys Glu Met Glu Gln Leu Arg Leu Ser Leu Ala Glu Glu 
        435                 440                 445             


Leu Ser Thr Tyr Lys Ala Met Leu Leu Pro Lys Ser Leu Glu Gln Ala 
    450                 455                 460                 


Asp Ala Pro Thr Ser Gln Ala Gly Gly Met Glu Thr Gln Ser Gln Gly 
465                 470                 475                 480 


Ala Val 
        


<210>  124
<211>  1197
<212>  PRT
<213>  Homo sapiens

<400>  124

Met His Ile Lys Ser Ile Ile Leu Glu Gly Phe Lys Ser Tyr Ala Gln 
1               5                   10                  15      


Arg Thr Glu Val Asn Gly Phe Asp Pro Leu Phe Asn Ala Ile Thr Gly 
            20                  25                  30          


Leu Asn Gly Ser Gly Lys Ser Asn Ile Leu Asp Ser Ile Cys Phe Leu 
        35                  40                  45              


Leu Gly Ile Ser Asn Leu Ser Gln Val Arg Ala Ser Asn Leu Gln Asp 
    50                  55                  60                  


Leu Val Tyr Lys Asn Gly Gln Ala Gly Ile Thr Lys Ala Ser Val Ser 
65                  70                  75                  80  


Ile Thr Phe Asp Asn Ser Asp Lys Lys Gln Ser Pro Leu Gly Phe Glu 
                85                  90                  95      


Val His Asp Glu Ile Thr Val Thr Arg Gln Val Val Ile Gly Gly Arg 
            100                 105                 110         


Asn Lys Tyr Leu Ile Asn Gly Val Asn Ala Asn Asn Thr Arg Val Gln 
        115                 120                 125             


Asp Leu Phe Cys Ser Val Gly Leu Asn Val Asn Asn Pro His Phe Leu 
    130                 135                 140                 


Ile Met Gln Gly Arg Ile Thr Lys Val Leu Asn Met Lys Pro Pro Glu 
145                 150                 155                 160 


Ile Leu Ser Met Ile Glu Glu Ala Ala Gly Thr Arg Met Tyr Glu Tyr 
                165                 170                 175     


Lys Lys Ile Ala Ala Gln Lys Thr Ile Glu Lys Lys Glu Ala Lys Leu 
            180                 185                 190         


Lys Glu Ile Lys Thr Ile Leu Glu Glu Glu Ile Thr Pro Thr Ile Gln 
        195                 200                 205             


Lys Leu Lys Glu Glu Arg Ser Ser Tyr Leu Glu Tyr Gln Lys Val Met 
    210                 215                 220                 


Arg Glu Ile Glu His Leu Ser Arg Leu Tyr Ile Ala Tyr Gln Phe Leu 
225                 230                 235                 240 


Leu Ala Glu Asp Thr Lys Val Arg Ser Ala Glu Glu Leu Lys Glu Met 
                245                 250                 255     


Gln Asp Lys Val Ile Lys Leu Gln Glu Glu Leu Ser Glu Asn Asp Lys 
            260                 265                 270         


Lys Ile Lys Ala Leu Asn His Glu Ile Glu Glu Leu Glu Lys Arg Lys 
        275                 280                 285             


Asp Lys Glu Thr Gly Gly Ile Leu Arg Ser Leu Glu Asp Ala Leu Ala 
    290                 295                 300                 


Glu Ala Gln Arg Val Asn Thr Lys Ser Gln Ser Ala Phe Asp Leu Lys 
305                 310                 315                 320 


Lys Lys Asn Leu Ala Cys Glu Glu Ser Lys Arg Lys Glu Leu Glu Lys 
                325                 330                 335     


Asn Met Val Glu Asp Ser Lys Thr Leu Ala Ala Lys Glu Lys Glu Val 
            340                 345                 350         


Lys Lys Ile Thr Asp Gly Leu His Ala Leu Gln Glu Ala Ser Asn Lys 
        355                 360                 365             


Asp Ala Glu Ala Leu Ala Ala Ala Gln Gln His Phe Asn Ala Val Ser 
    370                 375                 380                 


Ala Gly Leu Ser Ser Asn Glu Asp Gly Ala Glu Ala Thr Leu Ala Gly 
385                 390                 395                 400 


Gln Met Met Ala Cys Lys Asn Asp Ile Ser Lys Ala Gln Thr Glu Ala 
                405                 410                 415     


Lys Gln Ala Gln Met Lys Leu Lys His Ala Gln Gln Glu Leu Lys Asn 
            420                 425                 430         


Lys Gln Ala Glu Val Lys Lys Met Asp Ser Gly Tyr Arg Lys Asp Gln 
        435                 440                 445             


Glu Ala Leu Glu Ala Val Lys Arg Leu Lys Glu Lys Leu Glu Ala Glu 
    450                 455                 460                 


Met Lys Lys Leu Asn Tyr Glu Glu Asn Lys Glu Glu Ser Leu Leu Glu 
465                 470                 475                 480 


Lys Arg Arg Gln Leu Ser Arg Asp Ile Gly Arg Leu Lys Glu Thr Tyr 
                485                 490                 495     


Glu Ala Leu Leu Ala Arg Phe Pro Asn Leu Arg Phe Ala Tyr Lys Asp 
            500                 505                 510         


Pro Glu Lys Asn Trp Asn Arg Asn Cys Val Lys Gly Leu Val Ala Ser 
        515                 520                 525             


Leu Ile Ser Val Lys Asp Thr Ser Ala Thr Thr Ala Leu Glu Leu Val 
    530                 535                 540                 


Ala Gly Glu Arg Leu Tyr Asn Val Val Val Asp Thr Glu Val Thr Gly 
545                 550                 555                 560 


Lys Lys Leu Leu Glu Arg Gly Glu Leu Lys Arg Arg Tyr Thr Ile Ile 
                565                 570                 575     


Pro Leu Asn Lys Ile Ser Ala Arg Cys Ile Ala Pro Glu Thr Leu Arg 
            580                 585                 590         


Val Ala Gln Asn Leu Val Gly Pro Asp Asn Val His Val Ala Leu Ser 
        595                 600                 605             


Leu Val Glu Tyr Lys Pro Glu Leu Gln Lys Ala Met Glu Phe Val Phe 
    610                 615                 620                 


Gly Thr Thr Phe Val Cys Asp Asn Met Asp Asn Ala Lys Lys Val Ala 
625                 630                 635                 640 


Phe Asp Lys Arg Ile Met Thr Arg Thr Val Thr Leu Gly Gly Asp Val 
                645                 650                 655     


Phe Asp Pro His Gly Thr Leu Ser Gly Gly Ala Arg Ser Gln Ala Ala 
            660                 665                 670         


Ser Ile Leu Thr Lys Phe Gln Glu Leu Lys Asp Val Gln Asp Glu Leu 
        675                 680                 685             


Arg Ile Lys Glu Asn Glu Leu Arg Ala Leu Glu Glu Glu Leu Ala Gly 
    690                 695                 700                 


Leu Lys Asn Thr Ala Glu Lys Tyr Arg Gln Leu Lys Gln Gln Trp Glu 
705                 710                 715                 720 


Met Lys Thr Glu Glu Ala Asp Leu Leu Gln Thr Lys Leu Gln Gln Ser 
                725                 730                 735     


Ser Tyr His Lys Gln Gln Glu Glu Leu Asp Ala Leu Lys Lys Thr Ile 
            740                 745                 750         


Glu Glu Ser Glu Glu Thr Leu Lys Asn Thr Lys Glu Ile Gln Arg Lys 
        755                 760                 765             


Ala Glu Glu Lys Tyr Glu Val Leu Glu Asn Lys Met Lys Asn Ala Glu 
    770                 775                 780                 


Ala Glu Arg Glu Arg Glu Leu Lys Asp Ala Gln Lys Lys Leu Asp Cys 
785                 790                 795                 800 


Ala Lys Thr Lys Ala Asp Ala Ser Ser Lys Lys Met Lys Glu Lys Gln 
                805                 810                 815     


Gln Glu Val Glu Ala Ile Thr Leu Glu Leu Glu Glu Leu Lys Arg Glu 
            820                 825                 830         


His Thr Ser Tyr Lys Gln Gln Leu Glu Ala Val Asn Glu Ala Ile Lys 
        835                 840                 845             


Ser Tyr Glu Ser Gln Ile Glu Val Met Ala Ala Glu Val Ala Lys Asn 
    850                 855                 860                 


Lys Glu Ser Val Asn Lys Ala Gln Glu Glu Val Thr Lys Gln Lys Glu 
865                 870                 875                 880 


Val Ile Thr Ala Gln Asp Thr Val Ile Lys Ala Lys Tyr Ala Glu Val 
                885                 890                 895     


Ala Lys His Lys Glu Gln Asn Asn Asp Ser Gln Leu Lys Ile Lys Glu 
            900                 905                 910         


Leu Asp His Asn Ile Ser Lys His Lys Arg Glu Ala Glu Asp Gly Ala 
        915                 920                 925             


Ala Lys Val Ser Lys Met Leu Lys Asp Tyr Asp Trp Ile Asn Ala Glu 
    930                 935                 940                 


Arg His Leu Phe Gly Gln Pro Asn Ser Ala Tyr Asp Phe Lys Thr Asn 
945                 950                 955                 960 


Asn Pro Lys Glu Ala Gly Gln Arg Leu Gln Lys Leu Gln Glu Met Lys 
                965                 970                 975     


Glu Lys Leu Gly Arg Asn Val Asn Met Arg Ala Met Asn Val Leu Thr 
            980                 985                 990         


Glu Ala Glu Glu Arg Tyr Asn Asp  Leu Met Lys Lys Lys  Arg Ile Val 
        995                 1000                 1005             


Glu Asn  Asp Lys Ser Lys Ile  Leu Thr Thr Ile Glu  Asp Leu Asp 
    1010                 1015                 1020             


Gln Lys  Lys Asn Gln Ala Leu  Asn Ile Ala Trp Gln  Lys Val Asn 
    1025                 1030                 1035             


Lys Asp  Phe Gly Ser Ile Phe  Ser Thr Leu Leu Pro  Gly Ala Asn 
    1040                 1045                 1050             


Ala Met  Leu Ala Pro Pro Glu  Gly Gln Thr Val Leu  Asp Gly Leu 
    1055                 1060                 1065             


Glu Phe  Lys Val Ala Leu Gly  Asn Thr Trp Lys Glu  Asn Leu Thr 
    1070                 1075                 1080             


Glu Leu  Ser Gly Gly Gln Arg  Ser Leu Val Ala Leu  Ser Leu Ile 
    1085                 1090                 1095             


Leu Ser  Met Leu Leu Phe Lys  Pro Ala Pro Ile Tyr  Ile Leu Asp 
    1100                 1105                 1110             


Glu Val  Asp Ala Ala Leu Asp  Leu Ser His Thr Gln  Asn Ile Gly 
    1115                 1120                 1125             


Gln Met  Leu Arg Thr His Phe  Thr His Ser Gln Phe  Ile Val Val 
    1130                 1135                 1140             


Ser Leu  Lys Glu Gly Met Phe  Asn Asn Ala Asn Val  Leu Phe Lys 
    1145                 1150                 1155             


Thr Lys  Phe Val Asp Gly Val  Ser Thr Val Ala Arg  Phe Thr Gln 
    1160                 1165                 1170             


Cys Gln  Asn Gly Lys Ile Ser  Lys Glu Ala Lys Ser  Lys Ala Lys 
    1175                 1180                 1185             


Pro Pro  Lys Gly Ala His Val  Glu Val 
    1190                 1195         


<210>  125
<211>  1401
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Ala Pro Gln Met Tyr Glu Phe His Leu Pro Leu Ser Pro Glu Glu 
1               5                   10                  15      


Leu Leu Lys Ser Gly Gly Val Asn Gln Tyr Val Val Gln Glu Val Leu 
            20                  25                  30          


Ser Ile Lys His Leu Pro Pro Gln Leu Arg Ala Phe Gln Ala Ala Phe 
        35                  40                  45              


Arg Ala Gln Gly Pro Leu Ala Met Leu Gln His Phe Asp Thr Ile Tyr 
    50                  55                  60                  


Ser Ile Leu His His Phe Arg Ser Ile Asp Pro Gly Leu Lys Glu Asp 
65                  70                  75                  80  


Thr Leu Gln Phe Leu Ile Lys Val Val Ser Arg His Ser Gln Glu Leu 
                85                  90                  95      


Pro Ala Ile Leu Asp Asp Thr Thr Leu Ser Gly Ser Asp Arg Asn Ala 
            100                 105                 110         


His Leu Asn Ala Leu Lys Met Asn Cys Tyr Ala Leu Ile Arg Leu Leu 
        115                 120                 125             


Glu Ser Phe Glu Thr Met Ala Ser Gln Thr Asn Leu Val Asp Leu Asp 
    130                 135                 140                 


Leu Gly Gly Lys Gly Lys Lys Ala Arg Thr Lys Ala Ala His Gly Phe 
145                 150                 155                 160 


Asp Trp Glu Glu Glu Arg Gln Pro Ile Leu Gln Leu Leu Thr Gln Leu 
                165                 170                 175     


Leu Gln Leu Asp Ile Arg His Leu Trp Asn His Ser Ile Ile Glu Glu 
            180                 185                 190         


Glu Phe Val Ser Leu Val Thr Gly Cys Cys Tyr Arg Leu Leu Glu Asn 
        195                 200                 205             


Pro Thr Ile Asn His Gln Lys Asn Arg Pro Thr Arg Glu Ala Ile Thr 
    210                 215                 220                 


His Leu Leu Gly Val Ala Leu Thr Arg Tyr Asn His Met Leu Ser Ala 
225                 230                 235                 240 


Thr Val Lys Ile Ile Gln Met Leu Gln His Phe Glu His Leu Ala Pro 
                245                 250                 255     


Val Leu Val Ala Ala Val Ser Leu Trp Ala Thr Asp Tyr Gly Met Lys 
            260                 265                 270         


Ser Ile Val Gly Glu Ile Val Arg Glu Ile Gly Gln Lys Cys Pro Gln 
        275                 280                 285             


Glu Leu Ser Arg Asp Pro Ser Gly Thr Lys Gly Phe Ala Ala Phe Leu 
    290                 295                 300                 


Thr Glu Leu Ala Glu Arg Val Pro Ala Ile Leu Met Ser Ser Met Cys 
305                 310                 315                 320 


Ile Leu Leu Asp His Leu Asp Gly Glu Asn Tyr Met Met Arg Asn Ala 
                325                 330                 335     


Val Leu Ala Ala Met Ala Glu Met Val Leu Gln Val Leu Ser Gly Asp 
            340                 345                 350         


Gln Leu Glu Ala Ala Ala Arg Asp Thr Arg Asp Gln Phe Leu Asp Thr 
        355                 360                 365             


Leu Gln Ala His Gly His Asp Val Asn Ser Phe Val Arg Ser Arg Val 
    370                 375                 380                 


Leu Gln Leu Phe Thr Arg Ile Val Gln Gln Lys Ala Leu Pro Leu Thr 
385                 390                 395                 400 


Arg Phe Gln Ala Val Val Ala Leu Ala Val Gly Arg Leu Ala Asp Lys 
                405                 410                 415     


Ser Val Leu Val Cys Lys Asn Ala Ile Gln Leu Leu Ala Ser Phe Leu 
            420                 425                 430         


Ala Asn Asn Pro Phe Ser Cys Lys Leu Ser Asp Ala Asp Leu Ala Gly 
        435                 440                 445             


Pro Leu Gln Lys Glu Thr Gln Lys Leu Gln Glu Met Arg Ala Gln Arg 
    450                 455                 460                 


Arg Thr Ala Ala Ala Ser Ala Val Leu Asp Pro Glu Glu Glu Trp Glu 
465                 470                 475                 480 


Ala Met Leu Pro Glu Leu Lys Ser Thr Leu Gln Gln Leu Leu Gln Leu 
                485                 490                 495     


Pro Gln Gly Glu Glu Glu Ile Pro Glu Gln Ile Ala Asn Thr Glu Thr 
            500                 505                 510         


Thr Glu Asp Val Lys Gly Arg Ile Tyr Gln Leu Leu Ala Lys Ala Ser 
        515                 520                 525             


Tyr Lys Lys Ala Ile Ile Leu Thr Arg Glu Ala Thr Gly His Phe Gln 
    530                 535                 540                 


Glu Ser Glu Pro Phe Ser His Ile Asp Pro Glu Glu Ser Glu Glu Thr 
545                 550                 555                 560 


Arg Leu Leu Asn Ile Leu Gly Leu Ile Phe Lys Gly Pro Ala Ala Ser 
                565                 570                 575     


Thr Gln Glu Lys Asn Pro Arg Glu Ser Thr Gly Asn Met Val Thr Gly 
            580                 585                 590         


Gln Thr Val Cys Lys Asn Lys Pro Asn Met Ser Asp Pro Glu Glu Ser 
        595                 600                 605             


Arg Gly Asn Asp Glu Leu Val Lys Gln Glu Met Leu Val Gln Tyr Leu 
    610                 615                 620                 


Gln Asp Ala Tyr Ser Phe Ser Arg Lys Ile Thr Glu Ala Ile Gly Ile 
625                 630                 635                 640 


Ile Ser Lys Met Met Tyr Glu Asn Thr Thr Thr Val Val Gln Glu Val 
                645                 650                 655     


Ile Glu Phe Phe Val Met Val Phe Gln Phe Gly Val Pro Gln Ala Leu 
            660                 665                 670         


Phe Gly Val Arg Arg Met Leu Pro Leu Ile Trp Ser Lys Glu Pro Gly 
        675                 680                 685             


Val Arg Glu Ala Val Leu Asn Ala Tyr Arg Gln Leu Tyr Leu Asn Pro 
    690                 695                 700                 


Lys Gly Asp Ser Ala Arg Ala Lys Ala Gln Ala Leu Ile Gln Asn Leu 
705                 710                 715                 720 


Ser Leu Leu Leu Val Asp Ala Ser Val Gly Thr Ile Gln Cys Leu Glu 
                725                 730                 735     


Glu Ile Leu Cys Glu Phe Val Gln Lys Asp Glu Leu Lys Pro Ala Val 
            740                 745                 750         


Thr Gln Leu Leu Trp Glu Arg Ala Thr Glu Lys Val Ala Cys Cys Pro 
        755                 760                 765             


Leu Glu Arg Cys Ser Ser Val Met Leu Leu Gly Met Met Ala Arg Gly 
    770                 775                 780                 


Lys Pro Glu Ile Val Gly Ser Asn Leu Asp Thr Leu Val Ser Ile Gly 
785                 790                 795                 800 


Leu Asp Glu Lys Phe Pro Gln Asp Tyr Arg Leu Ala Gln Gln Val Cys 
                805                 810                 815     


His Ala Ile Ala Asn Ile Ser Asp Arg Arg Lys Pro Ser Leu Gly Lys 
            820                 825                 830         


Arg His Pro Pro Phe Arg Leu Pro Gln Glu His Arg Leu Phe Glu Arg 
        835                 840                 845             


Leu Arg Glu Thr Val Thr Lys Gly Phe Val His Pro Asp Pro Leu Trp 
    850                 855                 860                 


Ile Pro Phe Lys Glu Val Ala Val Thr Leu Ile Tyr Gln Leu Ala Glu 
865                 870                 875                 880 


Gly Pro Glu Val Ile Cys Ala Gln Ile Leu Gln Gly Cys Ala Lys Gln 
                885                 890                 895     


Ala Leu Glu Lys Leu Glu Glu Lys Arg Thr Ser Gln Glu Asp Pro Lys 
            900                 905                 910         


Glu Ser Pro Ala Met Leu Pro Thr Phe Leu Leu Met Asn Leu Leu Ser 
        915                 920                 925             


Leu Ala Gly Asp Val Ala Leu Gln Gln Leu Val His Leu Glu Gln Ala 
    930                 935                 940                 


Val Ser Gly Glu Leu Cys Arg Arg Arg Val Leu Arg Glu Glu Gln Glu 
945                 950                 955                 960 


His Lys Thr Lys Asp Pro Lys Glu Lys Asn Thr Ser Ser Glu Thr Thr 
                965                 970                 975     


Met Glu Glu Glu Leu Gly Leu Val Gly Ala Thr Ala Asp Asp Thr Glu 
            980                 985                 990         


Ala Glu Leu Ile Arg Gly Ile Cys  Glu Met Glu Leu Leu  Asp Gly Lys 
        995                 1000                 1005             


Gln Thr  Leu Ala Ala Phe Val  Pro Leu Leu Leu Lys  Val Cys Asn 
    1010                 1015                 1020             


Asn Pro  Gly Leu Tyr Ser Asn  Pro Asp Leu Ser Ala  Ala Ala Ser 
    1025                 1030                 1035             


Leu Ala  Leu Gly Lys Phe Cys  Met Ile Ser Ala Thr  Phe Cys Asp 
    1040                 1045                 1050             


Ser Gln  Leu Arg Leu Leu Phe  Thr Met Leu Glu Lys  Ser Pro Leu 
    1055                 1060                 1065             


Pro Ile  Val Arg Ser Asn Leu  Met Val Ala Thr Gly  Asp Leu Ala 
    1070                 1075                 1080             


Ile Arg  Phe Pro Asn Leu Val  Asp Pro Trp Thr Pro  His Leu Tyr 
    1085                 1090                 1095             


Ala Arg  Leu Arg Asp Pro Ala  Gln Gln Val Arg Lys  Thr Ala Gly 
    1100                 1105                 1110             


Leu Val  Met Thr His Leu Ile  Leu Lys Asp Met Val  Lys Val Lys 
    1115                 1120                 1125             


Gly Gln  Val Ser Glu Met Ala  Val Leu Leu Ile Asp  Pro Glu Pro 
    1130                 1135                 1140             


Gln Ile  Ala Ala Leu Ala Lys  Asn Phe Phe Asn Glu  Leu Ser His 
    1145                 1150                 1155             


Lys Gly  Asn Ala Ile Tyr Asn  Leu Leu Pro Asp Ile  Ile Ser Arg 
    1160                 1165                 1170             


Leu Ser  Asp Pro Glu Leu Gly  Val Glu Glu Glu Pro  Phe His Thr 
    1175                 1180                 1185             


Ile Met  Lys Gln Leu Leu Ser  Tyr Ile Thr Lys Asp  Lys Gln Thr 
    1190                 1195                 1200             


Glu Ser  Leu Val Glu Lys Leu  Cys Gln Arg Phe Arg  Thr Ser Arg 
    1205                 1210                 1215             


Thr Glu  Arg Gln Gln Arg Asp  Leu Ala Tyr Cys Val  Ser Gln Leu 
    1220                 1225                 1230             


Pro Leu  Thr Glu Arg Gly Leu  Arg Lys Met Leu Asp  Asn Phe Asp 
    1235                 1240                 1245             


Cys Phe  Gly Asp Lys Leu Ser  Asp Glu Ser Ile Phe  Ser Ala Phe 
    1250                 1255                 1260             


Leu Ser  Val Val Gly Lys Leu  Arg Arg Gly Ala Lys  Pro Glu Gly 
    1265                 1270                 1275             


Lys Ala  Ile Ile Asp Glu Phe  Glu Gln Lys Leu Arg  Ala Cys His 
    1280                 1285                 1290             


Thr Arg  Gly Leu Asp Gly Ile  Lys Glu Leu Glu Ile  Gly Gln Ala 
    1295                 1300                 1305             


Gly Ser  Gln Arg Ala Pro Ser  Ala Lys Lys Pro Ser  Thr Gly Ser 
    1310                 1315                 1320             


Arg Tyr  Gln Pro Leu Ala Ser  Thr Ala Ser Asp Asn  Asp Phe Val 
    1325                 1330                 1335             


Thr Pro  Glu Pro Arg Arg Thr  Thr Arg Arg His Pro  Asn Thr Gln 
    1340                 1345                 1350             


Gln Arg  Ala Ser Lys Lys Lys  Pro Lys Val Val Phe  Ser Ser Asp 
    1355                 1360                 1365             


Glu Ser  Ser Glu Glu Asp Leu  Ser Ala Glu Met Thr  Glu Asp Glu 
    1370                 1375                 1380             


Thr Pro  Lys Lys Thr Thr Pro  Ile Leu Arg Ala Ser  Ala Arg Arg 
    1385                 1390                 1395             


His Arg  Ser 
    1400     


<210>  126
<211>  930
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Lys Pro Pro Arg Pro Val Arg Thr Cys Ser Lys Val Leu Val Leu 
1               5                   10                  15      


Leu Ser Leu Leu Ala Ile His Gln Thr Thr Thr Ala Glu Lys Asn Gly 
            20                  25                  30          


Ile Asp Ile Tyr Ser Leu Thr Val Asp Ser Arg Val Ser Ser Arg Phe 
        35                  40                  45              


Ala His Thr Val Val Thr Ser Arg Val Val Asn Arg Ala Asn Thr Val 
    50                  55                  60                  


Gln Glu Ala Thr Phe Gln Met Glu Leu Pro Lys Lys Ala Phe Ile Thr 
65                  70                  75                  80  


Asn Phe Ser Met Ile Ile Asp Gly Met Thr Tyr Pro Gly Ile Ile Lys 
                85                  90                  95      


Glu Lys Ala Glu Ala Gln Ala Gln Tyr Ser Ala Ala Val Ala Lys Gly 
            100                 105                 110         


Lys Ser Ala Gly Leu Val Lys Ala Thr Gly Arg Asn Met Glu Gln Phe 
        115                 120                 125             


Gln Val Ser Val Ser Val Ala Pro Asn Ala Lys Ile Thr Phe Glu Leu 
    130                 135                 140                 


Val Tyr Glu Glu Leu Leu Lys Arg Arg Leu Gly Val Tyr Glu Leu Leu 
145                 150                 155                 160 


Leu Lys Val Arg Pro Gln Gln Leu Val Lys His Leu Gln Met Asp Ile 
                165                 170                 175     


His Ile Phe Glu Pro Gln Gly Ile Ser Phe Leu Glu Thr Glu Ser Thr 
            180                 185                 190         


Phe Met Thr Asn Gln Leu Val Asp Ala Leu Thr Thr Trp Gln Asn Lys 
        195                 200                 205             


Thr Lys Ala His Ile Arg Phe Lys Pro Thr Leu Ser Gln Gln Gln Lys 
    210                 215                 220                 


Ser Pro Glu Gln Gln Glu Thr Val Leu Asp Gly Asn Leu Ile Ile Arg 
225                 230                 235                 240 


Tyr Asp Val Asp Arg Ala Ile Ser Gly Gly Ser Ile Gln Ile Glu Asn 
                245                 250                 255     


Gly Tyr Phe Val His Tyr Phe Ala Pro Glu Gly Leu Thr Thr Met Pro 
            260                 265                 270         


Lys Asn Val Val Phe Val Ile Asp Lys Ser Gly Ser Met Ser Gly Arg 
        275                 280                 285             


Lys Ile Gln Gln Thr Arg Glu Ala Leu Ile Lys Ile Leu Asp Asp Leu 
    290                 295                 300                 


Ser Pro Arg Asp Gln Phe Asn Leu Ile Val Phe Ser Thr Glu Ala Thr 
305                 310                 315                 320 


Gln Trp Arg Pro Ser Leu Val Pro Ala Ser Ala Glu Asn Val Asn Lys 
                325                 330                 335     


Ala Arg Ser Phe Ala Ala Gly Ile Gln Ala Leu Gly Gly Thr Asn Ile 
            340                 345                 350         


Asn Asp Ala Met Leu Met Ala Val Gln Leu Leu Asp Ser Ser Asn Gln 
        355                 360                 365             


Glu Glu Arg Leu Pro Glu Gly Ser Val Ser Leu Ile Ile Leu Leu Thr 
    370                 375                 380                 


Asp Gly Asp Pro Thr Val Gly Glu Thr Asn Pro Arg Ser Ile Gln Asn 
385                 390                 395                 400 


Asn Val Arg Glu Ala Val Ser Gly Arg Tyr Ser Leu Phe Cys Leu Gly 
                405                 410                 415     


Phe Gly Phe Asp Val Ser Tyr Ala Phe Leu Glu Lys Leu Ala Leu Asp 
            420                 425                 430         


Asn Gly Gly Leu Ala Arg Arg Ile His Glu Asp Ser Asp Ser Ala Leu 
        435                 440                 445             


Gln Leu Gln Asp Phe Tyr Gln Glu Val Ala Asn Pro Leu Leu Thr Ala 
    450                 455                 460                 


Val Thr Phe Glu Tyr Pro Ser Asn Ala Val Glu Glu Val Thr Gln Asn 
465                 470                 475                 480 


Asn Phe Arg Leu Leu Phe Lys Gly Ser Glu Met Val Val Ala Gly Lys 
                485                 490                 495     


Leu Gln Asp Arg Gly Pro Asp Val Leu Thr Ala Thr Val Ser Gly Lys 
            500                 505                 510         


Leu Pro Thr Gln Asn Ile Thr Phe Gln Thr Glu Ser Ser Val Ala Glu 
        515                 520                 525             


Gln Glu Ala Glu Phe Gln Ser Pro Lys Tyr Ile Phe His Asn Phe Met 
    530                 535                 540                 


Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Gln Leu Leu Glu Gln Thr 
545                 550                 555                 560 


Val Ser Ala Ser Asp Ala Asp Gln Gln Ala Leu Arg Asn Gln Ala Leu 
                565                 570                 575     


Asn Leu Ser Leu Ala Tyr Ser Phe Val Thr Pro Leu Thr Ser Met Val 
            580                 585                 590         


Val Thr Lys Pro Asp Asp Gln Glu Gln Ser Gln Val Ala Glu Lys Pro 
        595                 600                 605             


Met Glu Gly Glu Ser Arg Asn Arg Asn Val His Ser Gly Ser Thr Phe 
    610                 615                 620                 


Phe Lys Tyr Tyr Leu Gln Gly Ala Lys Ile Pro Lys Pro Glu Ala Ser 
625                 630                 635                 640 


Phe Ser Pro Arg Arg Gly Trp Asn Arg Gln Ala Gly Ala Ala Gly Ser 
                645                 650                 655     


Arg Met Asn Phe Arg Pro Gly Val Leu Ser Ser Arg Gln Leu Gly Leu 
            660                 665                 670         


Pro Gly Pro Pro Asp Val Pro Asp His Ala Ala Tyr His Pro Phe Arg 
        675                 680                 685             


Arg Leu Ala Ile Leu Pro Ala Ser Ala Pro Pro Ala Thr Ser Asn Pro 
    690                 695                 700                 


Asp Pro Ala Val Ser Arg Val Met Asn Met Lys Ile Glu Glu Thr Thr 
705                 710                 715                 720 


Met Thr Thr Gln Thr Pro Ala Pro Ile Gln Ala Pro Ser Ala Ile Leu 
                725                 730                 735     


Pro Leu Pro Gly Gln Ser Val Glu Arg Leu Cys Val Asp Pro Arg His 
            740                 745                 750         


Arg Gln Gly Pro Val Asn Leu Leu Ser Asp Pro Glu Gln Gly Val Glu 
        755                 760                 765             


Val Thr Gly Gln Tyr Glu Arg Glu Lys Ala Gly Phe Ser Trp Ile Glu 
    770                 775                 780                 


Val Thr Phe Lys Asn Pro Leu Val Trp Val His Ala Ser Pro Glu His 
785                 790                 795                 800 


Val Val Val Thr Arg Asn Arg Arg Ser Ser Ala Tyr Lys Trp Lys Glu 
                805                 810                 815     


Thr Leu Phe Ser Val Met Pro Gly Leu Lys Met Thr Met Asp Lys Thr 
            820                 825                 830         


Gly Leu Leu Leu Leu Ser Asp Pro Asp Lys Val Thr Ile Gly Leu Leu 
        835                 840                 845             


Phe Trp Asp Gly Arg Gly Glu Gly Leu Arg Leu Leu Leu Arg Asp Thr 
    850                 855                 860                 


Asp Arg Phe Ser Ser His Val Gly Gly Thr Leu Gly Gln Phe Tyr Gln 
865                 870                 875                 880 


Glu Val Leu Trp Gly Ser Pro Ala Ala Ser Asp Asp Gly Arg Arg Thr 
                885                 890                 895     


Leu Arg Val Gln Gly Asn Asp His Ser Ala Thr Arg Glu Arg Arg Leu 
            900                 905                 910         


Asp Tyr Gln Glu Gly Pro Pro Gly Val Glu Ile Ser Cys Trp Ser Val 
        915                 920                 925             


Glu Leu 
    930 


<210>  127
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Pro Val Ala Gly Ser Glu Leu Pro Arg Arg Pro Leu Pro Pro Ala 
1               5                   10                  15      


Ala Gln Glu Arg Asp Ala Glu Pro Arg Pro Pro His Gly Glu Leu Gln 
            20                  25                  30          


Tyr Leu Gly Gln Ile Gln His Ile Leu Arg Cys Gly Val Arg Lys Asp 
        35                  40                  45              


Asp Arg Thr Gly Thr Gly Thr Leu Ser Val Phe Gly Met Gln Ala Arg 
    50                  55                  60                  


Tyr Ser Leu Arg Asp Glu Phe Pro Leu Leu Thr Thr Lys Arg Val Phe 
65                  70                  75                  80  


Trp Lys Gly Val Leu Glu Glu Leu Leu Trp Phe Ile Lys Gly Ser Thr 
                85                  90                  95      


Asn Ala Lys Glu Leu Ser Ser Lys Gly Val Lys Ile Trp Asp Ala Asn 
            100                 105                 110         


Gly Ser Arg Asp Phe Leu Asp Ser Leu Gly Phe Ser Thr Arg Glu Glu 
        115                 120                 125             


Gly Asp Leu Gly Pro Val Tyr Gly Phe Gln Trp Arg His Phe Gly Ala 
    130                 135                 140                 


Glu Tyr Arg Asp Met Glu Ser Asp Tyr Ser Gly Gln Gly Val Asp Gln 
145                 150                 155                 160 


Leu Gln Arg Val Ile Asp Thr Ile Lys Thr Asn Pro Asp Asp Arg Arg 
                165                 170                 175     


Ile Ile Met Cys Ala Trp Asn Pro Arg Asp Leu Pro Leu Met Ala Leu 
            180                 185                 190         


Pro Pro Cys His Ala Leu Cys Gln Phe Tyr Val Val Asn Ser Glu Leu 
        195                 200                 205             


Ser Cys Gln Leu Tyr Gln Arg Ser Gly Asp Met Gly Leu Gly Val Pro 
    210                 215                 220                 


Phe Asn Ile Ala Ser Tyr Ala Leu Leu Thr Tyr Met Ile Ala His Ile 
225                 230                 235                 240 


Thr Gly Leu Lys Pro Gly Asp Phe Ile His Thr Leu Gly Asp Ala His 
                245                 250                 255     


Ile Tyr Leu Asn His Ile Glu Pro Leu Lys Ile Gln Leu Gln Arg Glu 
            260                 265                 270         


Pro Arg Pro Phe Pro Lys Leu Arg Ile Leu Arg Lys Val Glu Lys Ile 
        275                 280                 285             


Asp Asp Phe Lys Ala Glu Asp Phe Gln Ile Glu Gly Tyr Asn Pro His 
    290                 295                 300                 


Pro Thr Ile Lys Met Glu Met Ala Val 
305                 310             


<210>  128
<211>  698
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Arg Leu Ala Val Gly Ala Leu Leu Val Cys Ala Val Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Val Pro Asp Lys Thr Val Arg Trp Cys Ala Val Ser Glu 
            20                  25                  30          


His Glu Ala Thr Lys Cys Gln Ser Phe Arg Asp His Met Lys Ser Val 
        35                  40                  45              


Ile Pro Ser Asp Gly Pro Ser Val Ala Cys Val Lys Lys Ala Ser Tyr 
    50                  55                  60                  


Leu Asp Cys Ile Arg Ala Ile Ala Ala Asn Glu Ala Asp Ala Val Thr 
65                  70                  75                  80  


Leu Asp Ala Gly Leu Val Tyr Asp Ala Tyr Leu Ala Pro Asn Asn Leu 
                85                  90                  95      


Lys Pro Val Val Ala Glu Phe Tyr Gly Ser Lys Glu Asp Pro Gln Thr 
            100                 105                 110         


Phe Tyr Tyr Ala Val Ala Val Val Lys Lys Asp Ser Gly Phe Gln Met 
        115                 120                 125             


Asn Gln Leu Arg Gly Lys Lys Ser Cys His Thr Gly Leu Gly Arg Ser 
    130                 135                 140                 


Ala Gly Trp Asn Ile Pro Ile Gly Leu Leu Tyr Cys Asp Leu Pro Glu 
145                 150                 155                 160 


Pro Arg Lys Pro Leu Glu Lys Ala Val Ala Asn Phe Phe Ser Gly Ser 
                165                 170                 175     


Cys Ala Pro Cys Ala Asp Gly Thr Asp Phe Pro Gln Leu Cys Gln Leu 
            180                 185                 190         


Cys Pro Gly Cys Gly Cys Ser Thr Leu Asn Gln Tyr Phe Gly Tyr Ser 
        195                 200                 205             


Gly Ala Phe Lys Cys Leu Lys Asp Gly Ala Gly Asp Val Ala Phe Val 
    210                 215                 220                 


Lys His Ser Thr Ile Phe Glu Asn Leu Ala Asn Lys Ala Asp Arg Asp 
225                 230                 235                 240 


Gln Tyr Glu Leu Leu Cys Leu Asp Asn Thr Arg Lys Pro Val Asp Glu 
                245                 250                 255     


Tyr Lys Asp Cys His Leu Ala Gln Val Pro Ser His Thr Val Val Ala 
            260                 265                 270         


Arg Ser Met Gly Gly Lys Glu Asp Leu Ile Trp Glu Leu Leu Asn Gln 
        275                 280                 285             


Ala Gln Glu His Phe Gly Lys Asp Lys Ser Lys Glu Phe Gln Leu Phe 
    290                 295                 300                 


Ser Ser Pro His Gly Lys Asp Leu Leu Phe Lys Asp Ser Ala His Gly 
305                 310                 315                 320 


Phe Leu Lys Val Pro Pro Arg Met Asp Ala Lys Met Tyr Leu Gly Tyr 
                325                 330                 335     


Glu Tyr Val Thr Ala Ile Arg Asn Leu Arg Glu Gly Thr Cys Pro Glu 
            340                 345                 350         


Ala Pro Thr Asp Glu Cys Lys Pro Val Lys Trp Cys Ala Leu Ser His 
        355                 360                 365             


His Glu Arg Leu Lys Cys Asp Glu Trp Ser Val Asn Ser Val Gly Lys 
    370                 375                 380                 


Ile Glu Cys Val Ser Ala Glu Thr Thr Glu Asp Cys Ile Ala Lys Ile 
385                 390                 395                 400 


Met Asn Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly Phe Val Tyr 
                405                 410                 415     


Ile Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr Asn 
            420                 425                 430         


Lys Ser Asp Asn Cys Glu Asp Thr Pro Glu Ala Gly Tyr Phe Ala Ile 
        435                 440                 445             


Ala Val Val Lys Lys Ser Ala Ser Asp Leu Thr Trp Asp Asn Leu Lys 
    450                 455                 460                 


Gly Lys Lys Ser Cys His Thr Ala Val Gly Arg Thr Ala Gly Trp Asn 
465                 470                 475                 480 


Ile Pro Met Gly Leu Leu Tyr Asn Lys Ile Asn His Cys Arg Phe Asp 
                485                 490                 495     


Glu Phe Phe Ser Glu Gly Cys Ala Pro Gly Ser Lys Lys Asp Ser Ser 
            500                 505                 510         


Leu Cys Lys Leu Cys Met Gly Ser Gly Leu Asn Leu Cys Glu Pro Asn 
        515                 520                 525             


Asn Lys Glu Gly Tyr Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Val 
    530                 535                 540                 


Glu Lys Gly Asp Val Ala Phe Val Lys His Gln Thr Val Pro Gln Asn 
545                 550                 555                 560 


Thr Gly Gly Lys Asn Pro Asp Pro Trp Ala Lys Asn Leu Asn Glu Lys 
                565                 570                 575     


Asp Tyr Glu Leu Leu Cys Leu Asp Gly Thr Arg Lys Pro Val Glu Glu 
            580                 585                 590         


Tyr Ala Asn Cys His Leu Ala Arg Ala Pro Asn His Ala Val Val Thr 
        595                 600                 605             


Arg Lys Asp Lys Glu Ala Cys Val His Lys Ile Leu Arg Gln Gln Gln 
    610                 615                 620                 


His Leu Phe Gly Ser Asn Val Thr Asp Cys Ser Gly Asn Phe Cys Leu 
625                 630                 635                 640 


Phe Arg Ser Glu Thr Lys Asp Leu Leu Phe Arg Asp Asp Thr Val Cys 
                645                 650                 655     


Leu Ala Lys Leu His Asp Arg Asn Thr Tyr Glu Lys Tyr Leu Gly Glu 
            660                 665                 670         


Glu Tyr Val Lys Ala Val Gly Asn Leu Arg Lys Cys Ser Thr Ser Ser 
        675                 680                 685             


Leu Leu Glu Ala Cys Thr Phe Arg Arg Pro 
    690                 695             


<210>  129
<211>  1482
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Arg Lys Asp Arg Leu Leu His Leu Cys Leu Val Leu Leu Leu Ile 
1               5                   10                  15      


Leu Leu Ser Ala Ser Asp Ser Asn Ser Thr Glu Pro Gln Tyr Met Val 
            20                  25                  30          


Leu Val Pro Ser Leu Leu His Thr Glu Ala Pro Lys Lys Gly Cys Val 
        35                  40                  45              


Leu Leu Ser His Leu Asn Glu Thr Val Thr Val Ser Ala Ser Leu Glu 
    50                  55                  60                  


Ser Gly Arg Glu Asn Arg Ser Leu Phe Thr Asp Leu Val Ala Glu Lys 
65                  70                  75                  80  


Asp Leu Phe His Cys Val Ser Phe Thr Leu Pro Arg Ile Ser Ala Ser 
                85                  90                  95      


Ser Glu Val Ala Phe Leu Ser Ile Gln Ile Lys Gly Pro Thr Gln Asp 
            100                 105                 110         


Phe Arg Lys Arg Asn Thr Val Leu Val Leu Asn Thr Gln Ser Leu Val 
        115                 120                 125             


Phe Val Gln Thr Asp Lys Pro Met Tyr Lys Pro Gly Gln Thr Val Arg 
    130                 135                 140                 


Phe Arg Val Val Ser Val Asp Glu Asn Phe Arg Pro Arg Asn Glu Leu 
145                 150                 155                 160 


Ile Pro Leu Ile Tyr Leu Glu Asn Pro Arg Arg Asn Arg Ile Ala Gln 
                165                 170                 175     


Trp Gln Ser Leu Lys Leu Glu Ala Gly Ile Asn Gln Leu Ser Phe Pro 
            180                 185                 190         


Leu Ser Ser Glu Pro Ile Gln Gly Ser Tyr Arg Val Val Val Gln Thr 
        195                 200                 205             


Glu Ser Gly Gly Arg Ile Gln His Pro Phe Thr Val Glu Glu Phe Val 
    210                 215                 220                 


Leu Pro Lys Phe Glu Val Lys Val Gln Val Pro Lys Ile Ile Ser Ile 
225                 230                 235                 240 


Met Asp Glu Lys Val Asn Ile Thr Val Cys Gly Glu Tyr Thr Tyr Gly 
                245                 250                 255     


Lys Pro Val Pro Gly Leu Ala Thr Val Ser Leu Cys Arg Lys Leu Ser 
            260                 265                 270         


Arg Val Leu Asn Cys Asp Lys Gln Glu Val Cys Glu Glu Phe Ser Gln 
        275                 280                 285             


Gln Leu Asn Ser Asn Gly Cys Ile Thr Gln Gln Val His Thr Lys Met 
    290                 295                 300                 


Leu Gln Ile Thr Asn Thr Gly Phe Glu Met Lys Leu Arg Val Glu Ala 
305                 310                 315                 320 


Arg Ile Arg Glu Glu Gly Thr Asp Leu Glu Val Thr Ala Asn Arg Ile 
                325                 330                 335     


Ser Glu Ile Thr Asn Ile Val Ser Lys Leu Lys Phe Val Lys Val Asp 
            340                 345                 350         


Ser His Phe Arg Gln Gly Ile Pro Phe Phe Ala Gln Val Leu Leu Val 
        355                 360                 365             


Asp Gly Lys Gly Val Pro Ile Pro Asn Lys Leu Phe Phe Ile Ser Val 
    370                 375                 380                 


Asn Asp Ala Asn Tyr Tyr Ser Asn Ala Thr Thr Asn Glu Gln Gly Leu 
385                 390                 395                 400 


Ala Gln Phe Ser Ile Asn Thr Thr Ser Ile Ser Val Asn Lys Leu Phe 
                405                 410                 415     


Val Arg Val Phe Thr Val His Pro Asn Leu Cys Phe His Tyr Ser Trp 
            420                 425                 430         


Val Ala Glu Asp His Gln Gly Ala Gln His Thr Ala Asn Arg Val Phe 
        435                 440                 445             


Ser Leu Ser Gly Ser Tyr Ile His Leu Glu Pro Val Ala Gly Thr Leu 
    450                 455                 460                 


Pro Cys Gly His Thr Glu Thr Ile Thr Ala His Tyr Thr Leu Asn Arg 
465                 470                 475                 480 


Gln Ala Met Gly Glu Leu Ser Glu Leu Ser Phe His Tyr Leu Ile Met 
                485                 490                 495     


Ala Lys Gly Val Ile Val Arg Ser Gly Thr His Thr Leu Pro Val Glu 
            500                 505                 510         


Ser Gly Asp Met Lys Gly Ser Phe Ala Leu Ser Phe Pro Val Glu Ser 
        515                 520                 525             


Asp Val Ala Pro Ile Ala Arg Met Phe Ile Phe Ala Ile Leu Pro Asp 
    530                 535                 540                 


Gly Glu Val Val Gly Asp Ser Glu Lys Phe Glu Ile Glu Asn Cys Leu 
545                 550                 555                 560 


Ala Asn Lys Val Asp Leu Ser Phe Ser Pro Ala Gln Ser Pro Pro Ala 
                565                 570                 575     


Ser His Ala His Leu Gln Val Ala Ala Ala Pro Gln Ser Leu Cys Ala 
            580                 585                 590         


Leu Arg Ala Val Asp Gln Ser Val Leu Leu Met Lys Pro Glu Ala Glu 
        595                 600                 605             


Leu Ser Val Ser Ser Val Tyr Asn Leu Leu Thr Val Lys Asp Leu Thr 
    610                 615                 620                 


Asn Phe Pro Asp Asn Val Asp Gln Gln Glu Glu Glu Gln Gly His Cys 
625                 630                 635                 640 


Pro Arg Pro Phe Phe Ile His Asn Gly Ala Ile Tyr Val Pro Leu Ser 
                645                 650                 655     


Ser Asn Glu Ala Asp Ile Tyr Ser Phe Leu Lys Gly Met Gly Leu Lys 
            660                 665                 670         


Val Phe Thr Asn Ser Lys Ile Arg Lys Pro Lys Ser Cys Ser Val Ile 
        675                 680                 685             


Pro Ser Val Ser Ala Gly Ala Val Gly Gln Gly Tyr Tyr Gly Ala Gly 
    690                 695                 700                 


Leu Gly Val Val Glu Arg Pro Tyr Val Pro Gln Leu Gly Thr Tyr Asn 
705                 710                 715                 720 


Val Ile Pro Leu Asn Asn Glu Gln Ser Ser Gly Pro Val Pro Glu Thr 
                725                 730                 735     


Val Arg Ser Tyr Phe Pro Glu Thr Trp Ile Trp Glu Leu Val Ala Val 
            740                 745                 750         


Asn Ser Ser Gly Val Ala Glu Val Gly Val Thr Val Pro Asp Thr Ile 
        755                 760                 765             


Thr Glu Trp Lys Ala Gly Ala Phe Cys Leu Ser Glu Asp Ala Gly Leu 
    770                 775                 780                 


Gly Ile Ser Ser Thr Ala Ser Leu Arg Ala Phe Gln Pro Phe Phe Val 
785                 790                 795                 800 


Glu Leu Thr Met Pro Tyr Ser Val Ile Arg Gly Glu Val Phe Thr Leu 
                805                 810                 815     


Lys Ala Thr Val Leu Asn Tyr Leu Pro Lys Cys Ile Arg Val Ser Val 
            820                 825                 830         


Gln Leu Lys Ala Ser Pro Ala Phe Leu Ala Ser Gln Asn Thr Lys Gly 
        835                 840                 845             


Glu Glu Ser Tyr Cys Ile Cys Gly Asn Glu Arg Gln Thr Leu Ser Trp 
    850                 855                 860                 


Thr Val Thr Pro Lys Thr Leu Gly Asn Val Asn Phe Ser Val Ser Ala 
865                 870                 875                 880 


Glu Ala Met Gln Ser Leu Glu Leu Cys Gly Asn Glu Val Val Glu Val 
                885                 890                 895     


Pro Glu Ile Lys Arg Lys Asp Thr Val Ile Lys Thr Leu Leu Val Glu 
            900                 905                 910         


Ala Glu Gly Ile Glu Gln Glu Lys Thr Phe Ser Ser Met Thr Cys Ala 
        915                 920                 925             


Ser Gly Ala Asn Val Ser Glu Gln Leu Ser Leu Lys Leu Pro Ser Asn 
    930                 935                 940                 


Val Val Lys Glu Ser Ala Arg Ala Ser Phe Ser Val Leu Gly Asp Ile 
945                 950                 955                 960 


Leu Gly Ser Ala Met Gln Asn Ile Gln Asn Leu Leu Gln Met Pro Tyr 
                965                 970                 975     


Gly Cys Gly Glu Gln Asn Met Val Leu Phe Ala Pro Asn Ile Tyr Val 
            980                 985                 990         


Leu Asn Tyr Leu Asn Glu Thr Gln  Gln Leu Thr Gln Glu  Ile Lys Ala 
        995                 1000                 1005             


Lys Ala  Val Gly Tyr Leu Ile  Thr Gly Tyr Gln Arg  Gln Leu Asn 
    1010                 1015                 1020             


Tyr Lys  His Gln Asp Gly Ser  Tyr Ser Thr Phe Gly  Glu Arg Tyr 
    1025                 1030                 1035             


Gly Arg  Asn Gln Gly Asn Thr  Trp Leu Thr Ala Phe  Val Leu Lys 
    1040                 1045                 1050             


Thr Phe  Ala Gln Ala Arg Ser  Tyr Ile Phe Ile Asp  Glu Ala His 
    1055                 1060                 1065             


Ile Thr  Gln Ser Leu Thr Trp  Leu Ser Gln Met Gln  Lys Asp Asn 
    1070                 1075                 1080             


Gly Cys  Phe Arg Ser Ser Gly  Ser Leu Leu Asn Asn  Ala Ile Lys 
    1085                 1090                 1095             


Gly Gly  Val Glu Asp Glu Ala  Thr Leu Ser Ala Tyr  Val Thr Ile 
    1100                 1105                 1110             


Ala Leu  Leu Glu Ile Pro Leu  Pro Val Thr Asn Pro  Ile Val Arg 
    1115                 1120                 1125             


Asn Ala  Leu Phe Cys Leu Glu  Ser Ala Trp Asn Val  Ala Lys Glu 
    1130                 1135                 1140             


Gly Thr  His Gly Ser His Val  Tyr Thr Lys Ala Leu  Leu Ala Tyr 
    1145                 1150                 1155             


Ala Phe  Ser Leu Leu Gly Lys  Gln Asn Gln Asn Arg  Glu Ile Leu 
    1160                 1165                 1170             


Asn Ser  Leu Asp Lys Glu Ala  Val Lys Glu Asp Asn  Leu Val His 
    1175                 1180                 1185             


Trp Glu  Arg Pro Gln Arg Pro  Lys Ala Pro Val Gly  His Leu Tyr 
    1190                 1195                 1200             


Gln Thr  Gln Ala Pro Ser Ala  Glu Val Glu Met Thr  Ser Tyr Val 
    1205                 1210                 1215             


Leu Leu  Ala Tyr Leu Thr Ala  Gln Pro Ala Pro Thr  Ser Gly Asp 
    1220                 1225                 1230             


Leu Thr  Ser Ala Thr Asn Ile  Val Lys Trp Ile Met  Lys Gln Gln 
    1235                 1240                 1245             


Asn Ala  Gln Gly Gly Phe Ser  Ser Thr Gln Asp Thr  Val Val Ala 
    1250                 1255                 1260             


Leu His  Ala Leu Ser Arg Tyr  Gly Ala Ala Thr Phe  Thr Arg Thr 
    1265                 1270                 1275             


Glu Lys  Thr Ala Gln Val Thr  Val Gln Asp Ser Gln  Thr Phe Ser 
    1280                 1285                 1290             


Thr Asn  Phe Gln Val Asp Asn  Asn Asn Leu Leu Leu  Leu Gln Gln 
    1295                 1300                 1305             


Ile Ser  Leu Pro Glu Leu Pro  Gly Glu Tyr Val Ile  Thr Val Thr 
    1310                 1315                 1320             


Gly Glu  Arg Cys Val Tyr Leu  Gln Thr Ser Met Lys  Tyr Asn Ile 
    1325                 1330                 1335             


Leu Pro  Glu Lys Glu Asp Ser  Pro Phe Ala Leu Lys  Val Gln Thr 
    1340                 1345                 1350             


Val Pro  Gln Thr Cys Asp Gly  His Lys Ala His Thr  Ser Phe Gln 
    1355                 1360                 1365             


Ile Ser  Leu Thr Ile Ser Tyr  Thr Gly Asn Arg Pro  Ala Ser Asn 
    1370                 1375                 1380             


Met Val  Ile Val Asp Val Lys  Met Val Ser Gly Phe  Ile Pro Leu 
    1385                 1390                 1395             


Lys Pro  Thr Val Lys Met Leu  Glu Arg Ser Ser Ser  Val Ser Arg 
    1400                 1405                 1410             


Thr Glu  Val Ser Asn Asn His  Val Leu Ile Tyr Val  Glu Gln Val 
    1415                 1420                 1425             


Thr Asn  Gln Thr Leu Ser Phe  Ser Phe Met Val Leu  Gln Asp Ile 
    1430                 1435                 1440             


Pro Val  Gly Asp Leu Lys Pro  Ala Ile Val Lys Val  Tyr Asp Tyr 
    1445                 1450                 1455             


Tyr Glu  Thr Asp Glu Ser Val  Val Ala Glu Tyr Ile  Ala Pro Cys 
    1460                 1465                 1470             


Ser Thr  Asp Thr Glu His Gly  Asn Val 
    1475                 1480         


<210>  130
<211>  719
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Ala Leu Lys Asp Tyr Ala Leu Glu Lys Glu Lys Val Lys Lys Phe 
1               5                   10                  15      


Leu Gln Glu Phe Tyr Gln Asp Asp Glu Leu Gly Lys Lys Gln Phe Lys 
            20                  25                  30          


Tyr Gly Asn Gln Leu Val Arg Leu Ala His Arg Glu Gln Val Ala Leu 
        35                  40                  45              


Tyr Val Asp Leu Asp Asp Val Ala Glu Asp Asp Pro Glu Leu Val Asp 
    50                  55                  60                  


Ser Ile Cys Glu Asn Ala Arg Arg Tyr Ala Lys Leu Phe Ala Asp Ala 
65                  70                  75                  80  


Val Gln Glu Leu Leu Pro Gln Tyr Lys Glu Arg Glu Val Val Asn Lys 
                85                  90                  95      


Asp Val Leu Asp Val Tyr Ile Glu His Arg Leu Met Met Glu Gln Arg 
            100                 105                 110         


Ser Arg Asp Pro Gly Met Val Arg Ser Pro Gln Asn Gln Tyr Pro Ala 
        115                 120                 125             


Glu Leu Met Arg Arg Phe Glu Leu Tyr Phe Gln Gly Pro Ser Ser Asn 
    130                 135                 140                 


Lys Pro Arg Val Ile Arg Glu Val Arg Ala Asp Ser Val Gly Lys Leu 
145                 150                 155                 160 


Val Thr Val Arg Gly Ile Val Thr Arg Val Ser Glu Val Lys Pro Lys 
                165                 170                 175     


Met Val Val Ala Thr Tyr Thr Cys Asp Gln Cys Gly Ala Glu Thr Tyr 
            180                 185                 190         


Gln Pro Ile Gln Ser Pro Thr Phe Met Pro Leu Ile Met Cys Pro Ser 
        195                 200                 205             


Gln Glu Cys Gln Thr Asn Arg Ser Gly Gly Arg Leu Tyr Leu Gln Thr 
    210                 215                 220                 


Arg Gly Ser Arg Phe Ile Lys Phe Gln Glu Met Lys Met Gln Glu His 
225                 230                 235                 240 


Ser Asp Gln Val Pro Val Gly Asn Ile Pro Arg Ser Ile Thr Val Leu 
                245                 250                 255     


Val Glu Gly Glu Asn Thr Arg Ile Ala Gln Pro Gly Asp His Val Ser 
            260                 265                 270         


Val Thr Gly Ile Phe Leu Pro Ile Leu Arg Thr Gly Phe Arg Gln Val 
        275                 280                 285             


Val Gln Gly Leu Leu Ser Glu Thr Tyr Leu Glu Ala His Arg Ile Val 
    290                 295                 300                 


Lys Met Asn Lys Ser Glu Asp Asp Glu Ser Gly Ala Gly Glu Leu Thr 
305                 310                 315                 320 


Arg Glu Glu Leu Arg Gln Ile Ala Glu Glu Asp Phe Tyr Glu Lys Leu 
                325                 330                 335     


Ala Ala Ser Ile Ala Pro Glu Ile Tyr Gly His Glu Asp Val Lys Lys 
            340                 345                 350         


Ala Leu Leu Leu Leu Leu Val Gly Gly Val Asp Gln Ser Pro Arg Gly 
        355                 360                 365             


Met Lys Ile Arg Gly Asn Ile Asn Ile Cys Leu Met Gly Asp Pro Gly 
    370                 375                 380                 


Val Ala Lys Ser Gln Leu Leu Ser Tyr Ile Asp Arg Leu Ala Pro Arg 
385                 390                 395                 400 


Ser Gln Tyr Thr Thr Gly Arg Gly Ser Ser Gly Val Gly Leu Thr Ala 
                405                 410                 415     


Ala Val Leu Arg Asp Ser Val Ser Gly Glu Leu Thr Leu Glu Gly Gly 
            420                 425                 430         


Ala Leu Val Leu Ala Asp Gln Gly Val Cys Cys Ile Asp Glu Phe Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Asp Arg Thr Ala Ile His Glu Val Met Glu Gln 
    450                 455                 460                 


Gln Thr Ile Ser Ile Ala Lys Ala Gly Ile Leu Thr Thr Leu Asn Ala 
465                 470                 475                 480 


Arg Cys Ser Ile Leu Ala Ala Ala Asn Pro Ala Tyr Gly Arg Tyr Asn 
                485                 490                 495     


Pro Arg Arg Ser Leu Glu Gln Asn Ile Gln Leu Pro Ala Ala Leu Leu 
            500                 505                 510         


Ser Arg Phe Asp Leu Leu Trp Leu Ile Gln Asp Arg Pro Asp Arg Asp 
        515                 520                 525             


Asn Asp Leu Arg Leu Ala Gln His Ile Thr Tyr Val His Gln His Ser 
    530                 535                 540                 


Arg Gln Pro Pro Ser Gln Phe Glu Pro Leu Asp Met Lys Leu Met Arg 
545                 550                 555                 560 


Arg Tyr Ile Ala Met Cys Arg Glu Lys Gln Pro Met Val Pro Glu Ser 
                565                 570                 575     


Leu Ala Asp Tyr Ile Thr Ala Ala Tyr Val Glu Met Arg Arg Glu Ala 
            580                 585                 590         


Trp Ala Ser Lys Asp Ala Thr Tyr Thr Ser Ala Arg Thr Leu Leu Ala 
        595                 600                 605             


Ile Leu Arg Leu Ser Thr Ala Leu Ala Arg Leu Arg Met Val Asp Val 
    610                 615                 620                 


Val Glu Lys Glu Asp Val Asn Glu Ala Ile Arg Leu Met Glu Met Ser 
625                 630                 635                 640 


Lys Asp Ser Leu Leu Gly Asp Lys Gly Gln Thr Ala Arg Thr Gln Arg 
                645                 650                 655     


Pro Ala Asp Val Ile Phe Ala Thr Val Arg Glu Leu Val Ser Gly Gly 
            660                 665                 670         


Arg Ser Val Arg Phe Ser Glu Ala Glu Gln Arg Cys Val Ser Arg Gly 
        675                 680                 685             


Phe Thr Pro Ala Gln Phe Gln Ala Ala Leu Asp Glu Tyr Glu Glu Leu 
    690                 695                 700                 


Asn Val Trp Gln Val Asn Ala Ser Arg Thr Arg Ile Thr Phe Val 
705                 710                 715                 


<210>  131
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Ala Arg Val Leu Gly Ala Pro Val Ala Leu Gly Leu Trp Ser Leu 
1               5                   10                  15      


Cys Trp Ser Leu Ala Ile Ala Thr Pro Leu Pro Pro Thr Ser Ala His 
            20                  25                  30          


Gly Asn Val Ala Glu Gly Glu Thr Lys Pro Asp Pro Asp Val Thr Glu 
        35                  40                  45              


Arg Cys Ser Asp Gly Trp Ser Phe Asp Ala Thr Thr Leu Asp Asp Asn 
    50                  55                  60                  


Gly Thr Met Leu Phe Phe Lys Gly Glu Phe Val Trp Lys Ser His Lys 
65                  70                  75                  80  


Trp Asp Arg Glu Leu Ile Ser Glu Arg Trp Lys Asn Phe Pro Ser Pro 
                85                  90                  95      


Val Asp Ala Ala Phe Arg Gln Gly His Asn Ser Val Phe Leu Ile Lys 
            100                 105                 110         


Gly Asp Lys Val Trp Val Tyr Pro Pro Glu Lys Lys Glu Lys Gly Tyr 
        115                 120                 125             


Pro Lys Leu Leu Gln Asp Glu Phe Pro Gly Ile Pro Ser Pro Leu Asp 
    130                 135                 140                 


Ala Ala Val Glu Cys His Arg Gly Glu Cys Gln Ala Glu Gly Val Leu 
145                 150                 155                 160 


Phe Phe Gln Gly Asp Arg Glu Trp Phe Trp Asp Leu Ala Thr Gly Thr 
                165                 170                 175     


Met Lys Glu Arg Ser Trp Pro Ala Val Gly Asn Cys Ser Ser Ala Leu 
            180                 185                 190         


Arg Trp Leu Gly Arg Tyr Tyr Cys Phe Gln Gly Asn Gln Phe Leu Arg 
        195                 200                 205             


Phe Asp Pro Val Arg Gly Glu Val Pro Pro Arg Tyr Pro Arg Asp Val 
    210                 215                 220                 


Arg Asp Tyr Phe Met Pro Cys Pro Gly Arg Gly His Gly His Arg Asn 
225                 230                 235                 240 


Gly Thr Gly His Gly Asn Ser Thr His His Gly Pro Glu Tyr Met Arg 
                245                 250                 255     


Cys Ser Pro His Leu Val Leu Ser Ala Leu Thr Ser Asp Asn His Gly 
            260                 265                 270         


Ala Thr Tyr Ala Phe Ser Gly Thr His Tyr Trp Arg Leu Asp Thr Ser 
        275                 280                 285             


Arg Asp Gly Trp His Ser Trp Pro Ile Ala His Gln Trp Pro Gln Gly 
    290                 295                 300                 


Pro Ser Ala Val Asp Ala Ala Phe Ser Trp Glu Glu Lys Leu Tyr Leu 
305                 310                 315                 320 


Val Gln Gly Thr Gln Val Tyr Val Phe Leu Thr Lys Gly Gly Tyr Thr 
                325                 330                 335     


Leu Val Ser Gly Tyr Pro Lys Arg Leu Glu Lys Glu Val Gly Thr Pro 
            340                 345                 350         


His Gly Ile Ile Leu Asp Ser Val Asp Ala Ala Phe Ile Cys Pro Gly 
        355                 360                 365             


Ser Ser Arg Leu His Ile Met Ala Gly Arg Arg Leu Trp Trp Leu Asp 
    370                 375                 380                 


Leu Lys Ser Gly Ala Gln Ala Thr Trp Thr Glu Leu Pro Trp Pro His 
385                 390                 395                 400 


Glu Lys Val Asp Gly Ala Leu Cys Met Glu Lys Ser Leu Gly Pro Asn 
                405                 410                 415     


Ser Cys Ser Ala Asn Gly Pro Gly Leu Tyr Leu Ile His Gly Pro Asn 
            420                 425                 430         


Leu Tyr Cys Tyr Ser Asp Val Glu Lys Leu Asn Ala Ala Lys Ala Leu 
        435                 440                 445             


Pro Gln Pro Gln Asn Val Thr Ser Leu Leu Gly Cys Thr His 
    450                 455                 460         


<210>  132
<211>  1360
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Ser Arg Gln Ser Thr Leu Tyr Ser Phe Phe Pro Lys Ser Pro Ala 
1               5                   10                  15      


Leu Ser Asp Ala Asn Lys Ala Ser Ala Arg Ala Ser Arg Glu Gly Gly 
            20                  25                  30          


Arg Ala Ala Ala Ala Pro Gly Ala Ser Pro Ser Pro Gly Gly Asp Ala 
        35                  40                  45              


Ala Trp Ser Glu Ala Gly Pro Gly Pro Arg Pro Leu Ala Arg Ser Ala 
    50                  55                  60                  


Ser Pro Pro Lys Ala Lys Asn Leu Asn Gly Gly Leu Arg Arg Ser Val 
65                  70                  75                  80  


Ala Pro Ala Ala Pro Thr Ser Cys Asp Phe Ser Pro Gly Asp Leu Val 
                85                  90                  95      


Trp Ala Lys Met Glu Gly Tyr Pro Trp Trp Pro Cys Leu Val Tyr Asn 
            100                 105                 110         


His Pro Phe Asp Gly Thr Phe Ile Arg Glu Lys Gly Lys Ser Val Arg 
        115                 120                 125             


Val His Val Gln Phe Phe Asp Asp Ser Pro Thr Arg Gly Trp Val Ser 
    130                 135                 140                 


Lys Arg Leu Leu Lys Pro Tyr Thr Gly Ser Lys Ser Lys Glu Ala Gln 
145                 150                 155                 160 


Lys Gly Gly His Phe Tyr Ser Ala Lys Pro Glu Ile Leu Arg Ala Met 
                165                 170                 175     


Gln Arg Ala Asp Glu Ala Leu Asn Lys Asp Lys Ile Lys Arg Leu Glu 
            180                 185                 190         


Leu Ala Val Cys Asp Glu Pro Ser Glu Pro Glu Glu Glu Glu Glu Met 
        195                 200                 205             


Glu Val Gly Thr Thr Tyr Val Thr Asp Lys Ser Glu Glu Asp Asn Glu 
    210                 215                 220                 


Ile Glu Ser Glu Glu Glu Val Gln Pro Lys Thr Gln Gly Ser Arg Arg 
225                 230                 235                 240 


Ser Ser Arg Gln Ile Lys Lys Arg Arg Val Ile Ser Asp Ser Glu Ser 
                245                 250                 255     


Asp Ile Gly Gly Ser Asp Val Glu Phe Lys Pro Asp Thr Lys Glu Glu 
            260                 265                 270         


Gly Ser Ser Asp Glu Ile Ser Ser Gly Val Gly Asp Ser Glu Ser Glu 
        275                 280                 285             


Gly Leu Asn Ser Pro Val Lys Val Ala Arg Lys Arg Lys Arg Met Val 
    290                 295                 300                 


Thr Gly Asn Gly Ser Leu Lys Arg Lys Ser Ser Arg Lys Glu Thr Pro 
305                 310                 315                 320 


Ser Ala Thr Lys Gln Ala Thr Ser Ile Ser Ser Glu Thr Lys Asn Thr 
                325                 330                 335     


Leu Arg Ala Phe Ser Ala Pro Gln Asn Ser Glu Ser Gln Ala His Val 
            340                 345                 350         


Ser Gly Gly Gly Asp Asp Ser Ser Arg Pro Thr Val Trp Tyr His Glu 
        355                 360                 365             


Thr Leu Glu Trp Leu Lys Glu Glu Lys Arg Arg Asp Glu His Arg Arg 
    370                 375                 380                 


Arg Pro Asp His Pro Asp Phe Asp Ala Ser Thr Leu Tyr Val Pro Glu 
385                 390                 395                 400 


Asp Phe Leu Asn Ser Cys Thr Pro Gly Met Arg Lys Trp Trp Gln Ile 
                405                 410                 415     


Lys Ser Gln Asn Phe Asp Leu Val Ile Cys Tyr Lys Val Gly Lys Phe 
            420                 425                 430         


Tyr Glu Leu Tyr His Met Asp Ala Leu Ile Gly Val Ser Glu Leu Gly 
        435                 440                 445             


Leu Val Phe Met Lys Gly Asn Trp Ala His Ser Gly Phe Pro Glu Ile 
    450                 455                 460                 


Ala Phe Gly Arg Tyr Ser Asp Ser Leu Val Gln Lys Gly Tyr Lys Val 
465                 470                 475                 480 


Ala Arg Val Glu Gln Thr Glu Thr Pro Glu Met Met Glu Ala Arg Cys 
                485                 490                 495     


Arg Lys Met Ala His Ile Ser Lys Tyr Asp Arg Val Val Arg Arg Glu 
            500                 505                 510         


Ile Cys Arg Ile Ile Thr Lys Gly Thr Gln Thr Tyr Ser Val Leu Glu 
        515                 520                 525             


Gly Asp Pro Ser Glu Asn Tyr Ser Lys Tyr Leu Leu Ser Leu Lys Glu 
    530                 535                 540                 


Lys Glu Glu Asp Ser Ser Gly His Thr Arg Ala Tyr Gly Val Cys Phe 
545                 550                 555                 560 


Val Asp Thr Ser Leu Gly Lys Phe Phe Ile Gly Gln Phe Ser Asp Asp 
                565                 570                 575     


Arg His Cys Ser Arg Phe Arg Thr Leu Val Ala His Tyr Pro Pro Val 
            580                 585                 590         


Gln Val Leu Phe Glu Lys Gly Asn Leu Ser Lys Glu Thr Lys Thr Ile 
        595                 600                 605             


Leu Lys Ser Ser Leu Ser Cys Ser Leu Gln Glu Gly Leu Ile Pro Gly 
    610                 615                 620                 


Ser Gln Phe Trp Asp Ala Ser Lys Thr Leu Arg Thr Leu Leu Glu Glu 
625                 630                 635                 640 


Glu Tyr Phe Arg Glu Lys Leu Ser Asp Gly Ile Gly Val Met Leu Pro 
                645                 650                 655     


Gln Val Leu Lys Gly Met Thr Ser Glu Ser Asp Ser Ile Gly Leu Thr 
            660                 665                 670         


Pro Gly Glu Lys Ser Glu Leu Ala Leu Ser Ala Leu Gly Gly Cys Val 
        675                 680                 685             


Phe Tyr Leu Lys Lys Cys Leu Ile Asp Gln Glu Leu Leu Ser Met Ala 
    690                 695                 700                 


Asn Phe Glu Glu Tyr Ile Pro Leu Asp Ser Asp Thr Val Ser Thr Thr 
705                 710                 715                 720 


Arg Ser Gly Ala Ile Phe Thr Lys Ala Tyr Gln Arg Met Val Leu Asp 
                725                 730                 735     


Ala Val Thr Leu Asn Asn Leu Glu Ile Phe Leu Asn Gly Thr Asn Gly 
            740                 745                 750         


Ser Thr Glu Gly Thr Leu Leu Glu Arg Val Asp Thr Cys His Thr Pro 
        755                 760                 765             


Phe Gly Lys Arg Leu Leu Lys Gln Trp Leu Cys Ala Pro Leu Cys Asn 
    770                 775                 780                 


His Tyr Ala Ile Asn Asp Arg Leu Asp Ala Ile Glu Asp Leu Met Val 
785                 790                 795                 800 


Val Pro Asp Lys Ile Ser Glu Val Val Glu Leu Leu Lys Lys Leu Pro 
                805                 810                 815     


Asp Leu Glu Arg Leu Leu Ser Lys Ile His Asn Val Gly Ser Pro Leu 
            820                 825                 830         


Lys Ser Gln Asn His Pro Asp Ser Arg Ala Ile Met Tyr Glu Glu Thr 
        835                 840                 845             


Thr Tyr Ser Lys Lys Lys Ile Ile Asp Phe Leu Ser Ala Leu Glu Gly 
    850                 855                 860                 


Phe Lys Val Met Cys Lys Ile Ile Gly Ile Met Glu Glu Val Ala Asp 
865                 870                 875                 880 


Gly Phe Lys Ser Lys Ile Leu Lys Gln Val Ile Ser Leu Gln Thr Lys 
                885                 890                 895     


Asn Pro Glu Gly Arg Phe Pro Asp Leu Thr Val Glu Leu Asn Arg Trp 
            900                 905                 910         


Asp Thr Ala Phe Asp His Glu Lys Ala Arg Lys Thr Gly Leu Ile Thr 
        915                 920                 925             


Pro Lys Ala Gly Phe Asp Ser Asp Tyr Asp Gln Ala Leu Ala Asp Ile 
    930                 935                 940                 


Arg Glu Asn Glu Gln Ser Leu Leu Glu Tyr Leu Glu Lys Gln Arg Asn 
945                 950                 955                 960 


Arg Ile Gly Cys Arg Thr Ile Val Tyr Trp Gly Ile Gly Arg Asn Arg 
                965                 970                 975     


Tyr Gln Leu Glu Ile Pro Glu Asn Phe Thr Thr Arg Asn Leu Pro Glu 
            980                 985                 990         


Glu Tyr Glu Leu Lys Ser Thr Lys  Lys Gly Cys Lys Arg  Tyr Trp Thr 
        995                 1000                 1005             


Lys Thr  Ile Glu Lys Lys Leu  Ala Asn Leu Ile Asn  Ala Glu Glu 
    1010                 1015                 1020             


Arg Arg  Asp Val Ser Leu Lys  Asp Cys Met Arg Arg  Leu Phe Tyr 
    1025                 1030                 1035             


Asn Phe  Asp Lys Asn Tyr Lys  Asp Trp Gln Ser Ala  Val Glu Cys 
    1040                 1045                 1050             


Ile Ala  Val Leu Asp Val Leu  Leu Cys Leu Ala Asn  Tyr Ser Arg 
    1055                 1060                 1065             


Gly Gly  Asp Gly Pro Met Cys  Arg Pro Val Ile Leu  Leu Pro Glu 
    1070                 1075                 1080             


Asp Thr  Pro Pro Phe Leu Glu  Leu Lys Gly Ser Arg  His Pro Cys 
    1085                 1090                 1095             


Ile Thr  Lys Thr Phe Phe Gly  Asp Asp Phe Ile Pro  Asn Asp Ile 
    1100                 1105                 1110             


Leu Ile  Gly Cys Glu Glu Glu  Glu Gln Glu Asn Gly  Lys Ala Tyr 
    1115                 1120                 1125             


Cys Val  Leu Val Thr Gly Pro  Asn Met Gly Gly Lys  Ser Thr Leu 
    1130                 1135                 1140             


Met Arg  Gln Ala Gly Leu Leu  Ala Val Met Ala Gln  Met Gly Cys 
    1145                 1150                 1155             


Tyr Val  Pro Ala Glu Val Cys  Arg Leu Thr Pro Ile  Asp Arg Val 
    1160                 1165                 1170             


Phe Thr  Arg Leu Gly Ala Ser  Asp Arg Ile Met Ser  Gly Glu Ser 
    1175                 1180                 1185             


Thr Phe  Phe Val Glu Leu Ser  Glu Thr Ala Ser Ile  Leu Met His 
    1190                 1195                 1200             


Ala Thr  Ala His Ser Leu Val  Leu Val Asp Glu Leu  Gly Arg Gly 
    1205                 1210                 1215             


Thr Ala  Thr Phe Asp Gly Thr  Ala Ile Ala Asn Ala  Val Val Lys 
    1220                 1225                 1230             


Glu Leu  Ala Glu Thr Ile Lys  Cys Arg Thr Leu Phe  Ser Thr His 
    1235                 1240                 1245             


Tyr His  Ser Leu Val Glu Asp  Tyr Ser Gln Asn Val  Ala Val Arg 
    1250                 1255                 1260             


Leu Gly  His Met Ala Cys Met  Val Glu Asn Glu Cys  Glu Asp Pro 
    1265                 1270                 1275             


Ser Gln  Glu Thr Ile Thr Phe  Leu Tyr Lys Phe Ile  Lys Gly Ala 
    1280                 1285                 1290             


Cys Pro  Lys Ser Tyr Gly Phe  Asn Ala Ala Arg Leu  Ala Asn Leu 
    1295                 1300                 1305             


Pro Glu  Glu Val Ile Gln Lys  Gly His Arg Lys Ala  Arg Glu Phe 
    1310                 1315                 1320             


Glu Lys  Met Asn Gln Ser Leu  Arg Leu Phe Arg Glu  Val Cys Leu 
    1325                 1330                 1335             


Ala Ser  Glu Arg Ser Thr Val  Asp Ala Glu Ala Val  His Lys Leu 
    1340                 1345                 1350             


Leu Thr  Leu Ile Lys Glu Leu  
    1355                 1360 


<210>  133
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Ser Ser Ala Cys Asp Ala Gly Asp His Tyr Pro Leu His Leu Leu 
1               5                   10                  15      


Val Trp Lys Asn Asp Tyr Arg Gln Leu Glu Lys Glu Leu Gln Gly Gln 
            20                  25                  30          


Asn Val Glu Ala Val Asp Pro Arg Gly Arg Thr Leu Leu His Leu Ala 
        35                  40                  45              


Val Ser Leu Gly His Leu Glu Ser Ala Arg Val Leu Leu Arg His Lys 
    50                  55                  60                  


Ala Asp Val Thr Lys Glu Asn Arg Gln Gly Trp Thr Val Leu His Glu 
65                  70                  75                  80  


Ala Val Ser Thr Gly Asp Pro Glu Met Val Tyr Thr Val Leu Gln His 
                85                  90                  95      


Arg Asp Tyr His Asn Thr Ser Met Ala Leu Glu Gly Val Pro Glu Leu 
            100                 105                 110         


Leu Gln Lys Ile Leu Glu Ala Pro Asp Phe Tyr Val Gln Met Lys Trp 
        115                 120                 125             


Glu Phe Thr Ser Trp Val Pro Leu Val Ser Arg Ile Cys Pro Asn Asp 
    130                 135                 140                 


Val Cys Arg Ile Trp Lys Ser Gly Ala Lys Leu Arg Val Asp Ile Thr 
145                 150                 155                 160 


Leu Leu Gly Phe Glu Asn Met Ser Trp Ile Arg Gly Arg Arg Ser Phe 
                165                 170                 175     


Ile Phe Lys Gly Glu Asp Asn Trp Ala Glu Leu Met Glu Val Asn His 
            180                 185                 190         


Asp Asp Lys Val Val Thr Thr Glu Arg Phe Asp Leu Ser Gln Glu Met 
        195                 200                 205             


Glu Arg Leu Thr Leu Asp Leu Met Lys Pro Lys Ser Arg Glu Val Glu 
    210                 215                 220                 


Arg Arg Leu Thr Ser Pro Val Ile Asn Thr Ser Leu Asp Thr Lys Asn 
225                 230                 235                 240 


Ile Ala Phe Glu Arg Thr Lys Ser Gly Phe Trp Gly Trp Arg Thr Asp 
                245                 250                 255     


Lys Ala Glu Val Val Asn Gly Tyr Glu Ala Lys Val Tyr Thr Val Asn 
            260                 265                 270         


Asn Val Asn Val Ile Thr Lys Ile Arg Thr Glu His Leu Thr Glu Glu 
        275                 280                 285             


Glu Lys Lys Arg Tyr Lys Ala Asp Arg Asn Pro Leu Glu Ser Leu Leu 
    290                 295                 300                 


Gly Thr Val Glu His Gln Phe Gly Ala Gln Gly Asp Leu Thr Thr Glu 
305                 310                 315                 320 


Cys Ala Thr Ala Asn Asn Pro Thr Ala Ile Thr Pro Asp Glu Tyr Phe 
                325                 330                 335     


Asn Glu Glu Phe Asp Leu Lys Asp Arg Asp Ile Gly Arg Pro Lys Glu 
            340                 345                 350         


Leu Thr Ile Arg Thr Gln Lys Phe Lys Ala Met Leu Trp Met Cys Glu 
        355                 360                 365             


Glu Phe Pro Leu Ser Leu Val Glu Gln Val Ile Pro Ile Ile Asp Leu 
    370                 375                 380                 


Met Ala Arg Thr Ser Ala His Phe Ala Arg Leu Arg Asp Phe Ile Lys 
385                 390                 395                 400 


Leu Glu Phe Pro Pro Gly Phe Pro Val Lys Ile Glu Ile Pro Leu Phe 
                405                 410                 415     


His Val Leu Asn Ala Arg Ile Thr Phe Gly Asn Val Asn Gly Cys Ser 
            420                 425                 430         


Thr Ala Glu Glu Ser Val Ser Gln Asn Val Glu Gly Thr Gln Ala Asp 
        435                 440                 445             


Ser Ala Ser His Ile Thr Asn Phe Glu Val Asp Gln Ser Val Phe Glu 
    450                 455                 460                 


Ile Pro Glu Ser Tyr Tyr Val Gln Asp Asn Gly Arg Asn Val His Leu 
465                 470                 475                 480 


Gln Asp Glu Asp Tyr Glu Ile Met Gln Phe Ala Ile Gln Gln Ser Leu 
                485                 490                 495     


Leu Glu Ser Ser Arg Ser Gln Glu Leu Ser Gly Pro Ala Ser Asn Gly 
            500                 505                 510         


Gly Ile Ser Gln Thr Asn Thr Tyr Asp Ala Gln Tyr Glu Arg Ala Ile 
        515                 520                 525             


Gln Glu Ser Leu Leu Thr Ser Thr Glu Gly Leu Cys Pro Ser Ala Leu 
    530                 535                 540                 


Ser Glu Thr Ser Arg Phe Asp Asn Asp Leu Gln Leu Ala Met Glu Leu 
545                 550                 555                 560 


Ser Ala Lys Glu Leu Glu Glu Trp Glu Leu Arg Leu Gln Glu Glu Glu 
                565                 570                 575     


Ala Glu Leu Gln Gln Val Leu Gln Leu Ser Leu Thr Asp Lys 
            580                 585                 590 


<210>  134
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Gln Asp Pro Asn Ala Asp Thr Glu Trp Asn Asp Ile Leu Arg Lys 
1               5                   10                  15      


Lys Gly Ile Leu Pro Pro Lys Glu Ser Leu Lys Glu Leu Glu Glu Glu 
            20                  25                  30          


Ala Glu Glu Glu Gln Arg Ile Leu Gln Gln Ser Val Val Lys Thr Tyr 
        35                  40                  45              


Glu Asp Met Thr Leu Glu Glu Leu Glu Asp His Glu Asp Glu Phe Asn 
    50                  55                  60                  


Glu Glu Asp Glu Arg Ala Ile Glu Met Tyr Arg Arg Arg Arg Leu Ala 
65                  70                  75                  80  


Glu Trp Lys Ala Thr Lys Leu Lys Asn Lys Phe Gly Glu Val Leu Glu 
                85                  90                  95      


Ile Ser Gly Lys Asp Tyr Val Gln Glu Val Thr Lys Ala Gly Glu Gly 
            100                 105                 110         


Leu Trp Val Ile Leu His Leu Tyr Lys Gln Gly Ile Pro Leu Cys Ala 
        115                 120                 125             


Leu Ile Asn Gln His Leu Ser Gly Leu Ala Arg Lys Phe Pro Asp Val 
    130                 135                 140                 


Lys Phe Ile Lys Ala Ile Ser Thr Thr Cys Ile Pro Asn Tyr Pro Asp 
145                 150                 155                 160 


Arg Asn Leu Pro Thr Ile Phe Val Tyr Leu Glu Gly Asp Ile Lys Ala 
                165                 170                 175     


Gln Phe Ile Gly Pro Leu Val Phe Gly Gly Met Asn Leu Thr Arg Asp 
            180                 185                 190         


Glu Leu Glu Trp Lys Leu Ser Glu Ser Gly Ala Ile Met Thr Asp Leu 
        195                 200                 205             


Glu Glu Asn Pro Lys Lys Pro Ile Glu Asp Val Leu Leu Ser Ser Val 
    210                 215                 220                 


Arg Arg Ser Val Leu Met Lys Arg Asp Ser Asp Ser Glu Gly Asp 
225                 230                 235                 


<210>  135
<211>  1234
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Ala Gly Ala Gln Pro Gly Val His Ala Leu Gln Leu Glu Pro Pro 
1               5                   10                  15      


Thr Val Val Glu Thr Leu Arg Arg Gly Ser Lys Phe Ile Lys Trp Asp 
            20                  25                  30          


Glu Glu Thr Ser Ser Arg Asn Leu Val Thr Leu Arg Val Asp Pro Asn 
        35                  40                  45              


Gly Phe Phe Leu Tyr Trp Thr Gly Pro Asn Met Glu Val Asp Thr Leu 
    50                  55                  60                  


Asp Ile Ser Ser Ile Arg Asp Thr Arg Thr Gly Arg Tyr Ala Arg Leu 
65                  70                  75                  80  


Pro Lys Asp Pro Lys Ile Arg Glu Val Leu Gly Phe Gly Gly Pro Asp 
                85                  90                  95      


Ala Arg Leu Glu Glu Lys Leu Met Thr Val Val Ser Gly Pro Asp Pro 
            100                 105                 110         


Val Asn Thr Val Phe Leu Asn Phe Met Ala Val Gln Asp Asp Thr Ala 
        115                 120                 125             


Lys Val Trp Ser Glu Glu Leu Phe Lys Leu Ala Met Asn Ile Leu Ala 
    130                 135                 140                 


Gln Asn Ala Ser Arg Asn Thr Phe Leu Arg Lys Ala Tyr Thr Lys Leu 
145                 150                 155                 160 


Lys Leu Gln Val Asn Gln Asp Gly Arg Ile Pro Val Lys Asn Ile Leu 
                165                 170                 175     


Lys Met Phe Ser Ala Asp Lys Lys Arg Val Glu Thr Ala Leu Glu Ser 
            180                 185                 190         


Cys Gly Leu Lys Phe Asn Arg Ser Glu Ser Ile Arg Pro Asp Glu Phe 
        195                 200                 205             


Ser Leu Glu Ile Phe Glu Arg Phe Leu Asn Lys Leu Cys Leu Arg Pro 
    210                 215                 220                 


Asp Ile Asp Lys Ile Leu Leu Glu Ile Gly Ala Lys Gly Lys Pro Tyr 
225                 230                 235                 240 


Leu Thr Leu Glu Gln Leu Met Asp Phe Ile Asn Gln Lys Gln Arg Asp 
                245                 250                 255     


Pro Arg Leu Asn Glu Val Leu Tyr Pro Pro Leu Arg Pro Ser Gln Ala 
            260                 265                 270         


Arg Leu Leu Ile Glu Lys Tyr Glu Pro Asn Gln Gln Phe Leu Glu Arg 
        275                 280                 285             


Asp Gln Met Ser Met Glu Gly Phe Ser Arg Tyr Leu Gly Gly Glu Glu 
    290                 295                 300                 


Asn Gly Ile Leu Pro Leu Glu Ala Leu Asp Leu Ser Thr Asp Met Thr 
305                 310                 315                 320 


Gln Pro Leu Ser Ala Tyr Phe Ile Asn Ser Ser His Asn Thr Tyr Leu 
                325                 330                 335     


Thr Ala Gly Gln Leu Ala Gly Thr Ser Ser Val Glu Met Tyr Arg Gln 
            340                 345                 350         


Ala Leu Leu Trp Gly Cys Arg Cys Val Glu Leu Asp Val Trp Lys Gly 
        355                 360                 365             


Arg Pro Pro Glu Glu Glu Pro Phe Ile Thr His Gly Phe Thr Met Thr 
    370                 375                 380                 


Thr Glu Val Pro Leu Arg Asp Val Leu Glu Ala Ile Ala Glu Thr Ala 
385                 390                 395                 400 


Phe Lys Thr Ser Pro Tyr Pro Val Ile Leu Ser Phe Glu Asn His Val 
                405                 410                 415     


Asp Ser Ala Lys Gln Gln Ala Lys Met Ala Glu Tyr Cys Arg Ser Ile 
            420                 425                 430         


Phe Gly Asp Ala Leu Leu Ile Glu Pro Leu Asp Lys Tyr Pro Leu Ala 
        435                 440                 445             


Pro Gly Val Pro Leu Pro Ser Pro Gln Asp Leu Met Gly Arg Ile Leu 
    450                 455                 460                 


Val Lys Asn Lys Lys Arg His Arg Pro Ser Ala Gly Gly Pro Asp Ser 
465                 470                 475                 480 


Ala Gly Arg Lys Arg Pro Leu Glu Gln Ser Asn Ser Ala Leu Ser Glu 
                485                 490                 495     


Ser Ser Ala Ala Thr Glu Pro Ser Ser Pro Gln Leu Gly Ser Pro Ser 
            500                 505                 510         


Ser Asp Ser Cys Pro Gly Leu Ser Asn Gly Glu Glu Val Gly Leu Glu 
        515                 520                 525             


Lys Pro Ser Leu Glu Pro Gln Lys Ser Leu Gly Asp Glu Gly Leu Asn 
    530                 535                 540                 


Arg Gly Pro Tyr Val Leu Gly Pro Ala Asp Arg Glu Asp Glu Glu Glu 
545                 550                 555                 560 


Asp Glu Glu Glu Glu Glu Gln Thr Asp Pro Lys Lys Pro Thr Thr Asp 
                565                 570                 575     


Glu Gly Thr Ala Ser Ser Glu Val Asn Ala Thr Glu Glu Met Ser Thr 
            580                 585                 590         


Leu Val Asn Tyr Ile Glu Pro Val Lys Phe Lys Ser Phe Glu Ala Ala 
        595                 600                 605             


Arg Lys Arg Asn Lys Cys Phe Glu Met Ser Ser Phe Val Glu Thr Lys 
    610                 615                 620                 


Ala Met Glu Gln Leu Thr Lys Ser Pro Met Glu Phe Val Glu Tyr Asn 
625                 630                 635                 640 


Lys Gln Gln Leu Ser Arg Ile Tyr Pro Lys Gly Thr Arg Val Asp Ser 
                645                 650                 655     


Ser Asn Tyr Met Pro Gln Leu Phe Trp Asn Val Gly Cys Gln Leu Val 
            660                 665                 670         


Ala Leu Asn Phe Gln Thr Leu Asp Val Ala Met Gln Leu Asn Ala Gly 
        675                 680                 685             


Val Phe Glu Tyr Asn Gly Arg Ser Gly Tyr Leu Leu Lys Pro Glu Phe 
    690                 695                 700                 


Met Arg Arg Pro Asp Lys Ser Phe Asp Pro Phe Thr Glu Val Ile Val 
705                 710                 715                 720 


Asp Gly Ile Val Ala Asn Ala Leu Arg Val Lys Val Ile Ser Gly Gln 
                725                 730                 735     


Phe Leu Ser Asp Arg Lys Val Gly Ile Tyr Val Glu Val Asp Met Phe 
            740                 745                 750         


Gly Leu Pro Val Asp Thr Arg Arg Lys Tyr Arg Thr Arg Thr Ser Gln 
        755                 760                 765             


Gly Asn Ser Phe Asn Pro Val Trp Asp Glu Glu Pro Phe Asp Phe Pro 
    770                 775                 780                 


Lys Val Val Leu Pro Thr Leu Ala Ser Leu Arg Ile Ala Ala Phe Glu 
785                 790                 795                 800 


Glu Gly Gly Lys Phe Val Gly His Arg Ile Leu Pro Val Ser Ala Ile 
                805                 810                 815     


Arg Ser Gly Tyr His Tyr Val Cys Leu Arg Asn Glu Ala Asn Gln Pro 
            820                 825                 830         


Leu Cys Leu Pro Ala Leu Leu Ile Tyr Thr Glu Ala Ser Asp Tyr Ile 
        835                 840                 845             


Pro Asp Asp His Gln Asp Tyr Ala Glu Ala Leu Ile Asn Pro Ile Lys 
    850                 855                 860                 


His Val Ser Leu Met Asp Gln Arg Ala Arg Gln Leu Ala Ala Leu Ile 
865                 870                 875                 880 


Gly Glu Ser Glu Ala Gln Ala Gly Gln Glu Thr Cys Gln Asp Thr Gln 
                885                 890                 895     


Ser Gln Gln Leu Gly Ser Gln Pro Ser Ser Asn Pro Thr Pro Ser Pro 
            900                 905                 910         


Leu Asp Ala Ser Pro Arg Arg Pro Pro Gly Pro Thr Thr Ser Pro Ala 
        915                 920                 925             


Ser Thr Ser Leu Ser Ser Pro Gly Gln Arg Asp Asp Leu Ile Ala Ser 
    930                 935                 940                 


Ile Leu Ser Glu Val Ala Pro Thr Pro Leu Asp Glu Leu Arg Gly His 
945                 950                 955                 960 


Lys Ala Leu Val Lys Leu Arg Ser Arg Gln Glu Arg Asp Leu Arg Glu 
                965                 970                 975     


Leu Arg Lys Lys His Gln Arg Lys Ala Val Thr Leu Thr Arg Arg Leu 
            980                 985                 990         


Leu Asp Gly Leu Ala Gln Ala Gln  Ala Glu Gly Arg Cys  Arg Leu Arg 
        995                 1000                 1005             


Pro Gly  Ala Leu Gly Gly Ala  Ala Asp Val Glu Asp  Thr Lys Glu 
    1010                 1015                 1020             


Gly Glu  Asp Glu Ala Lys Arg  Tyr Gln Glu Phe Gln  Asn Arg Gln 
    1025                 1030                 1035             


Val Gln  Ser Leu Leu Glu Leu  Arg Glu Ala Gln Val  Asp Ala Glu 
    1040                 1045                 1050             


Ala Gln  Arg Arg Leu Glu His  Leu Arg Gln Ala Leu  Gln Arg Leu 
    1055                 1060                 1065             


Arg Glu  Val Val Leu Asp Ala  Asn Thr Thr Gln Phe  Lys Arg Leu 
    1070                 1075                 1080             


Lys Glu  Met Asn Glu Arg Glu  Lys Lys Glu Leu Gln  Lys Ile Leu 
    1085                 1090                 1095             


Asp Arg  Lys Arg His Asn Ser  Ile Ser Glu Ala Lys  Met Arg Asp 
    1100                 1105                 1110             


Lys His  Lys Lys Glu Ala Glu  Leu Thr Glu Ile Asn  Arg Arg His 
    1115                 1120                 1125             


Ile Thr  Glu Ser Val Asn Ser  Ile Arg Arg Leu Glu  Glu Ala Gln 
    1130                 1135                 1140             


Lys Gln  Arg His Asp Arg Leu  Val Ala Gly Gln Gln  Gln Val Leu 
    1145                 1150                 1155             


Gln Gln  Leu Ala Glu Glu Glu  Pro Lys Leu Leu Ala  Gln Leu Ala 
    1160                 1165                 1170             


Gln Glu  Cys Gln Glu Gln Arg  Ala Arg Leu Pro Gln  Glu Ile Arg 
    1175                 1180                 1185             


Arg Ser  Leu Leu Gly Glu Met  Pro Glu Gly Leu Gly  Asp Gly Pro 
    1190                 1195                 1200             


Leu Val  Ala Cys Ala Ser Asn  Gly His Ala Pro Gly  Ser Ser Gly 
    1205                 1210                 1215             


His Leu  Ser Gly Ala Asp Ser  Glu Ser Gln Glu Glu  Asn Thr Gln 
    1220                 1225                 1230             


Leu 
    


<210>  136
<211>  1663
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Thr His 
1               5                   10                  15      


Leu Pro Leu Ala Leu Gly Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn 
            20                  25                  30          


Ile Leu Arg Leu Glu Ser Glu Glu Thr Met Val Leu Glu Ala His Asp 
        35                  40                  45              


Ala Gln Gly Asp Val Pro Val Thr Val Thr Val His Asp Phe Pro Gly 
    50                  55                  60                  


Lys Lys Leu Val Leu Ser Ser Glu Lys Thr Val Leu Thr Pro Ala Thr 
65                  70                  75                  80  


Asn His Met Gly Asn Val Thr Phe Thr Ile Pro Ala Asn Arg Glu Phe 
                85                  90                  95      


Lys Ser Glu Lys Gly Arg Asn Lys Phe Val Thr Val Gln Ala Thr Phe 
            100                 105                 110         


Gly Thr Gln Val Val Glu Lys Val Val Leu Val Ser Leu Gln Ser Gly 
        115                 120                 125             


Tyr Leu Phe Ile Gln Thr Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr 
    130                 135                 140                 


Val Leu Tyr Arg Ile Phe Thr Val Asn His Lys Leu Leu Pro Val Gly 
145                 150                 155                 160 


Arg Thr Val Met Val Asn Ile Glu Asn Pro Glu Gly Ile Pro Val Lys 
                165                 170                 175     


Gln Asp Ser Leu Ser Ser Gln Asn Gln Leu Gly Val Leu Pro Leu Ser 
            180                 185                 190         


Trp Asp Ile Pro Glu Leu Val Asn Met Gly Gln Trp Lys Ile Arg Ala 
        195                 200                 205             


Tyr Tyr Glu Asn Ser Pro Gln Gln Val Phe Ser Thr Glu Phe Glu Val 
    210                 215                 220                 


Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Ile Val Glu Pro Thr Glu 
225                 230                 235                 240 


Lys Phe Tyr Tyr Ile Tyr Asn Glu Lys Gly Leu Glu Val Thr Ile Thr 
                245                 250                 255     


Ala Arg Phe Leu Tyr Gly Lys Lys Val Glu Gly Thr Ala Phe Val Ile 
            260                 265                 270         


Phe Gly Ile Gln Asp Gly Glu Gln Arg Ile Ser Leu Pro Glu Ser Leu 
        275                 280                 285             


Lys Arg Ile Pro Ile Glu Asp Gly Ser Gly Glu Val Val Leu Ser Arg 
    290                 295                 300                 


Lys Val Leu Leu Asp Gly Val Gln Asn Pro Arg Ala Glu Asp Leu Val 
305                 310                 315                 320 


Gly Lys Ser Leu Tyr Val Ser Ala Thr Val Ile Leu His Ser Gly Ser 
                325                 330                 335     


Asp Met Val Gln Ala Glu Arg Ser Gly Ile Pro Ile Val Thr Ser Pro 
            340                 345                 350         


Tyr Gln Ile His Phe Thr Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met 
        355                 360                 365             


Pro Phe Asp Leu Met Val Phe Val Thr Asn Pro Asp Gly Ser Pro Ala 
    370                 375                 380                 


Tyr Arg Val Pro Val Ala Val Gln Gly Glu Asp Thr Val Gln Ser Leu 
385                 390                 395                 400 


Thr Gln Gly Asp Gly Val Ala Lys Leu Ser Ile Asn Thr His Pro Ser 
                405                 410                 415     


Gln Lys Pro Leu Ser Ile Thr Val Arg Thr Lys Lys Gln Glu Leu Ser 
            420                 425                 430         


Glu Ala Glu Gln Ala Thr Arg Thr Met Gln Ala Leu Pro Tyr Ser Thr 
        435                 440                 445             


Val Gly Asn Ser Asn Asn Tyr Leu His Leu Ser Val Leu Arg Thr Glu 
    450                 455                 460                 


Leu Arg Pro Gly Glu Thr Leu Asn Val Asn Phe Leu Leu Arg Met Asp 
465                 470                 475                 480 


Arg Ala His Glu Ala Lys Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn 
                485                 490                 495     


Lys Gly Arg Leu Leu Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln 
            500                 505                 510         


Asp Leu Val Val Leu Pro Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser 
        515                 520                 525             


Phe Arg Leu Val Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg 
    530                 535                 540                 


Glu Val Val Ala Asp Ser Val Trp Val Asp Val Lys Asp Ser Cys Val 
545                 550                 555                 560 


Gly Ser Leu Val Val Lys Ser Gly Gln Ser Glu Asp Arg Gln Pro Val 
                565                 570                 575     


Pro Gly Gln Gln Met Thr Leu Lys Ile Glu Gly Asp His Gly Ala Arg 
            580                 585                 590         


Val Val Leu Val Ala Val Asp Lys Gly Val Phe Val Leu Asn Lys Lys 
        595                 600                 605             


Asn Lys Leu Thr Gln Ser Lys Ile Trp Asp Val Val Glu Lys Ala Asp 
    610                 615                 620                 


Ile Gly Cys Thr Pro Gly Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser 
625                 630                 635                 640 


Asp Ala Gly Leu Thr Phe Thr Ser Ser Ser Gly Gln Gln Thr Ala Gln 
                645                 650                 655     


Arg Ala Glu Leu Gln Cys Pro Gln Pro Ala Ala Arg Arg Arg Arg Ser 
            660                 665                 670         


Val Gln Leu Thr Glu Lys Arg Met Asp Lys Val Gly Lys Tyr Pro Lys 
        675                 680                 685             


Glu Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Glu Asn Pro Met Arg 
    690                 695                 700                 


Phe Ser Cys Gln Arg Arg Thr Arg Phe Ile Ser Leu Gly Glu Ala Cys 
705                 710                 715                 720 


Lys Lys Val Phe Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg Arg 
                725                 730                 735     


Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg Ser Asn Leu Asp 
            740                 745                 750         


Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg Ser Glu Phe Pro 
        755                 760                 765             


Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu Pro Pro Lys Asn 
    770                 775                 780                 


Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys Asp Ser Ile Thr 
785                 790                 795                 800 


Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys Lys Gly Ile Cys 
                805                 810                 815     


Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp Phe Phe Ile Asp 
            820                 825                 830         


Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln Val Glu Ile Arg 
        835                 840                 845             


Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu Lys Val Arg Val 
    850                 855                 860                 


Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala Thr Thr Lys Arg 
865                 870                 875                 880 


Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser Ser Leu Ser Val 
                885                 890                 895     


Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln Glu Val Glu Val 
            900                 905                 910         


Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly Val Arg Lys Ser 
        915                 920                 925             


Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys Thr Val Ala Val 
    930                 935                 940                 


Arg Thr Leu Asp Pro Glu Arg Leu Gly Arg Glu Gly Val Gln Lys Glu 
945                 950                 955                 960 


Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro Asp Thr Glu Ser 
                965                 970                 975     


Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro Val Ala Gln Met Thr Glu 
            980                 985                 990         


Asp Ala Val Asp Ala Glu Arg Leu  Lys His Leu Ile Val  Thr Pro Ser 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Asn Met  Ile Gly Met Thr Pro  Thr Val Ile 
    1010                 1015                 1020             


Ala Val  His Tyr Leu Asp Glu  Thr Glu Gln Trp Glu  Lys Phe Gly 
    1025                 1030                 1035             


Leu Glu  Lys Arg Gln Gly Ala  Leu Glu Leu Ile Lys  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Gln  Gln Leu Ala Phe Arg  Gln Pro Ser Ser Ala  Phe Ala Ala 
    1055                 1060                 1065             


Phe Val  Lys Arg Ala Pro Ser  Thr Trp Leu Thr Ala  Tyr Val Val 
    1070                 1075                 1080             


Lys Val  Phe Ser Leu Ala Val  Asn Leu Ile Ala Ile  Asp Ser Gln 
    1085                 1090                 1095             


Val Leu  Cys Gly Ala Val Lys  Trp Leu Ile Leu Glu  Lys Gln Lys 
    1100                 1105                 1110             


Pro Asp  Gly Val Phe Gln Glu  Asp Ala Pro Val Ile  His Gln Glu 
    1115                 1120                 1125             


Met Ile  Gly Gly Leu Arg Asn  Asn Asn Glu Lys Asp  Met Ala Leu 
    1130                 1135                 1140             


Thr Ala  Phe Val Leu Ile Ser  Leu Gln Glu Ala Lys  Asp Ile Cys 
    1145                 1150                 1155             


Glu Glu  Gln Val Asn Ser Leu  Pro Gly Ser Ile Thr  Lys Ala Gly 
    1160                 1165                 1170             


Asp Phe  Leu Glu Ala Asn Tyr  Met Asn Leu Gln Arg  Ser Tyr Thr 
    1175                 1180                 1185             


Val Ala  Ile Ala Gly Tyr Ala  Leu Ala Gln Met Gly  Arg Leu Lys 
    1190                 1195                 1200             


Gly Pro  Leu Leu Asn Lys Phe  Leu Thr Thr Ala Lys  Asp Lys Asn 
    1205                 1210                 1215             


Arg Trp  Glu Asp Pro Gly Lys  Gln Leu Tyr Asn Val  Glu Ala Thr 
    1220                 1225                 1230             


Ser Tyr  Ala Leu Leu Ala Leu  Leu Gln Leu Lys Asp  Phe Asp Phe 
    1235                 1240                 1245             


Val Pro  Pro Val Val Arg Trp  Leu Asn Glu Gln Arg  Tyr Tyr Gly 
    1250                 1255                 1260             


Gly Gly  Tyr Gly Ser Thr Gln  Ala Thr Phe Met Val  Phe Gln Ala 
    1265                 1270                 1275             


Leu Ala  Gln Tyr Gln Lys Asp  Ala Pro Asp His Gln  Glu Leu Asn 
    1280                 1285                 1290             


Leu Asp  Val Ser Leu Gln Leu  Pro Ser Arg Ser Ser  Lys Ile Thr 
    1295                 1300                 1305             


His Arg  Ile His Trp Glu Ser  Ala Ser Leu Leu Arg  Ser Glu Glu 
    1310                 1315                 1320             


Thr Lys  Glu Asn Glu Gly Phe  Thr Val Thr Ala Glu  Gly Lys Gly 
    1325                 1330                 1335             


Gln Gly  Thr Leu Ser Val Val  Thr Met Tyr His Ala  Lys Ala Lys 
    1340                 1345                 1350             


Asp Gln  Leu Thr Cys Asn Lys  Phe Asp Leu Lys Val  Thr Ile Lys 
    1355                 1360                 1365             


Pro Ala  Pro Glu Thr Glu Lys  Arg Pro Gln Asp Ala  Lys Asn Thr 
    1370                 1375                 1380             


Met Ile  Leu Glu Ile Cys Thr  Arg Tyr Arg Gly Asp  Gln Asp Ala 
    1385                 1390                 1395             


Thr Met  Ser Ile Leu Asp Ile  Ser Met Met Thr Gly  Phe Ala Pro 
    1400                 1405                 1410             


Asp Thr  Asp Asp Leu Lys Gln  Leu Ala Asn Gly Val  Asp Arg Tyr 
    1415                 1420                 1425             


Ile Ser  Lys Tyr Glu Leu Asp  Lys Ala Phe Ser Asp  Arg Asn Thr 
    1430                 1435                 1440             


Leu Ile  Ile Tyr Leu Asp Lys  Val Ser His Ser Glu  Asp Asp Cys 
    1445                 1450                 1455             


Leu Ala  Phe Lys Val His Gln  Tyr Phe Asn Val Glu  Leu Ile Gln 
    1460                 1465                 1470             


Pro Gly  Ala Val Lys Val Tyr  Ala Tyr Tyr Asn Leu  Glu Glu Ser 
    1475                 1480                 1485             


Cys Thr  Arg Phe Tyr His Pro  Glu Lys Glu Asp Gly  Lys Leu Asn 
    1490                 1495                 1500             


Lys Leu  Cys Arg Asp Glu Leu  Cys Arg Cys Ala Glu  Glu Asn Cys 
    1505                 1510                 1515             


Phe Ile  Gln Lys Ser Asp Asp  Lys Val Thr Leu Glu  Glu Arg Leu 
    1520                 1525                 1530             


Asp Lys  Ala Cys Glu Pro Gly  Val Asp Tyr Val Tyr  Lys Thr Arg 
    1535                 1540                 1545             


Leu Val  Lys Val Gln Leu Ser  Asn Asp Phe Asp Glu  Tyr Ile Met 
    1550                 1555                 1560             


Ala Ile  Glu Gln Thr Ile Lys  Ser Gly Ser Asp Glu  Val Gln Val 
    1565                 1570                 1575             


Gly Gln  Gln Arg Thr Phe Ile  Ser Pro Ile Lys Cys  Arg Glu Ala 
    1580                 1585                 1590             


Leu Lys  Leu Glu Glu Lys Lys  His Tyr Leu Met Trp  Gly Leu Ser 
    1595                 1600                 1605             


Ser Asp  Phe Trp Gly Glu Lys  Pro Asn Leu Ser Tyr  Ile Ile Gly 
    1610                 1615                 1620             


Lys Asp  Thr Trp Val Glu His  Trp Pro Glu Glu Asp  Glu Cys Gln 
    1625                 1630                 1635             


Asp Glu  Glu Asn Gln Lys Gln  Cys Gln Asp Leu Gly  Ala Phe Thr 
    1640                 1645                 1650             


Glu Ser  Met Val Val Phe Gly  Cys Pro Asn 
    1655                 1660             


<210>  137
<211>  808
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Ala Gly Thr Val Val Leu Asp Asp Val Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Arg Asp Tyr Leu Asp Phe Leu Asp Asp Glu Glu Asp Gln Gly Ile Tyr 
            20                  25                  30          


Gln Ser Lys Val Arg Glu Leu Ile Ser Asp Asn Gln Tyr Arg Leu Ile 
        35                  40                  45              


Val Asn Val Asn Asp Leu Arg Arg Lys Asn Glu Lys Arg Ala Asn Arg 
    50                  55                  60                  


Leu Leu Asn Asn Ala Phe Glu Glu Leu Val Ala Phe Gln Arg Ala Leu 
65                  70                  75                  80  


Lys Asp Phe Val Ala Ser Ile Asp Ala Thr Tyr Ala Lys Gln Tyr Glu 
                85                  90                  95      


Glu Phe Tyr Val Gly Leu Glu Gly Ser Phe Gly Ser Lys His Val Ser 
            100                 105                 110         


Pro Arg Thr Leu Thr Ser Cys Phe Leu Ser Cys Val Val Cys Val Glu 
        115                 120                 125             


Gly Ile Val Thr Lys Cys Ser Leu Val Arg Pro Lys Val Val Arg Ser 
    130                 135                 140                 


Val His Tyr Cys Pro Ala Thr Lys Lys Thr Ile Glu Arg Arg Tyr Ser 
145                 150                 155                 160 


Asp Leu Thr Thr Leu Val Ala Phe Pro Ser Ser Ser Val Tyr Pro Thr 
                165                 170                 175     


Lys Asp Glu Glu Asn Asn Pro Leu Glu Thr Glu Tyr Gly Leu Ser Val 
            180                 185                 190         


Tyr Lys Asp His Gln Thr Ile Thr Ile Gln Glu Met Pro Glu Lys Ala 
        195                 200                 205             


Pro Ala Gly Gln Leu Pro Arg Ser Val Asp Val Ile Leu Asp Asp Asp 
    210                 215                 220                 


Leu Val Asp Lys Ala Lys Pro Gly Asp Arg Val Gln Val Val Gly Thr 
225                 230                 235                 240 


Tyr Arg Cys Leu Pro Gly Lys Lys Gly Gly Tyr Thr Ser Gly Thr Phe 
                245                 250                 255     


Arg Thr Val Leu Ile Ala Cys Asn Val Lys Gln Met Ser Lys Asp Ala 
            260                 265                 270         


Gln Pro Ser Phe Ser Ala Glu Asp Ile Ala Lys Ile Lys Lys Phe Ser 
        275                 280                 285             


Lys Thr Arg Ser Lys Asp Ile Phe Asp Gln Leu Ala Lys Ser Leu Ala 
    290                 295                 300                 


Pro Ser Ile His Gly His Asp Tyr Val Lys Lys Ala Ile Leu Cys Leu 
305                 310                 315                 320 


Leu Leu Gly Gly Val Glu Arg Asp Leu Glu Asn Gly Ser His Ile Arg 
                325                 330                 335     


Gly Asp Ile Asn Ile Leu Leu Ile Gly Asp Pro Ser Val Ala Lys Ser 
            340                 345                 350         


Gln Leu Leu Arg Tyr Val Leu Cys Thr Ala Pro Arg Ala Ile Pro Thr 
        355                 360                 365             


Thr Gly Arg Gly Ser Ser Gly Val Gly Leu Thr Ala Ala Val Thr Thr 
    370                 375                 380                 


Asp Gln Glu Thr Gly Glu Arg Arg Leu Glu Ala Gly Ala Met Val Leu 
385                 390                 395                 400 


Ala Asp Arg Gly Val Val Cys Ile Asp Glu Phe Asp Lys Met Ser Asp 
                405                 410                 415     


Met Asp Arg Thr Ala Ile His Glu Val Met Glu Gln Gly Arg Val Thr 
            420                 425                 430         


Ile Ala Lys Ala Gly Ile His Ala Arg Leu Asn Ala Arg Cys Ser Val 
        435                 440                 445             


Leu Ala Ala Ala Asn Pro Val Tyr Gly Arg Tyr Asp Gln Tyr Lys Thr 
    450                 455                 460                 


Pro Met Glu Asn Ile Gly Leu Gln Asp Ser Leu Leu Ser Arg Phe Asp 
465                 470                 475                 480 


Leu Leu Phe Ile Met Leu Asp Gln Met Asp Pro Glu Gln Asp Arg Glu 
                485                 490                 495     


Ile Ser Asp His Val Leu Arg Met His Arg Tyr Arg Ala Pro Gly Glu 
            500                 505                 510         


Gln Asp Gly Asp Ala Met Pro Leu Gly Ser Ala Val Asp Ile Leu Ala 
        515                 520                 525             


Thr Asp Asp Pro Asn Phe Ser Gln Glu Asp Gln Gln Asp Thr Gln Ile 
    530                 535                 540                 


Tyr Glu Lys His Asp Asn Leu Leu His Gly Thr Lys Lys Lys Lys Glu 
545                 550                 555                 560 


Lys Met Val Ser Ala Ala Phe Met Lys Lys Tyr Ile His Val Ala Lys 
                565                 570                 575     


Ile Ile Lys Pro Val Leu Thr Gln Glu Ser Ala Thr Tyr Ile Ala Glu 
            580                 585                 590         


Glu Tyr Ser Arg Leu Arg Ser Gln Asp Ser Met Ser Ser Asp Thr Ala 
        595                 600                 605             


Arg Thr Ser Pro Val Thr Ala Arg Thr Leu Glu Thr Leu Ile Arg Leu 
    610                 615                 620                 


Ala Thr Ala His Ala Lys Ala Arg Met Ser Lys Thr Val Asp Leu Gln 
625                 630                 635                 640 


Asp Ala Glu Glu Ala Val Glu Leu Val Gln Tyr Ala Tyr Phe Lys Lys 
                645                 650                 655     


Val Leu Glu Lys Glu Lys Lys Arg Lys Lys Arg Ser Glu Asp Glu Ser 
            660                 665                 670         


Glu Thr Glu Asp Glu Glu Glu Lys Ser Gln Glu Asp Gln Glu Gln Lys 
        675                 680                 685             


Arg Lys Arg Arg Lys Thr Arg Gln Pro Asp Ala Lys Asp Gly Asp Ser 
    690                 695                 700                 


Tyr Asp Pro Tyr Asp Phe Ser Asp Thr Glu Glu Glu Met Pro Gln Val 
705                 710                 715                 720 


His Thr Pro Lys Thr Ala Asp Ser Gln Glu Thr Lys Glu Ser Gln Lys 
                725                 730                 735     


Val Glu Leu Ser Glu Ser Arg Leu Lys Ala Phe Lys Val Ala Leu Leu 
            740                 745                 750         


Asp Val Phe Arg Glu Ala His Ala Gln Ser Ile Gly Met Asn Arg Leu 
        755                 760                 765             


Thr Glu Ser Ile Asn Arg Asp Ser Glu Glu Pro Phe Ser Ser Val Glu 
    770                 775                 780                 


Ile Gln Ala Ala Leu Ser Lys Met Gln Asp Asp Asn Gln Val Met Val 
785                 790                 795                 800 


Ser Glu Gly Ile Ile Phe Leu Ile 
                805             


<210>  138
<211>  835
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro 
1               5                   10                  15      


Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln 
            20                  25                  30          


Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe 
        35                  40                  45              


Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp 
    50                  55                  60                  


Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser 
65                  70                  75                  80  


Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly 
                85                  90                  95      


Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu Ser Glu Asn 
            100                 105                 110         


Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg Leu Cys Lys 
        115                 120                 125             


Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr Cys Gln Cys 
    130                 135                 140                 


Leu Pro Gly Phe Lys Phe Ile Pro Glu Asp Pro Lys Val Cys Thr Asp 
145                 150                 155                 160 


Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser Ser Thr His 
                165                 170                 175     


Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg Pro Gly Trp 
            180                 185                 190         


Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr Val Cys Glu 
        195                 200                 205             


Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser Ser Thr 
    210                 215                 220                 


Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys Arg Pro Gly 
225                 230                 235                 240 


Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Thr Val Cys 
                245                 250                 255     


Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly Val His Ser 
            260                 265                 270         


Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu Gly Arg Asp 
        275                 280                 285             


Ser Lys Thr Ser Ser Ala Glu Val Thr Ile Gln Asn Val Ile Lys Leu 
    290                 295                 300                 


Val Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala Leu Ala Pro 
305                 310                 315                 320 


Pro Val Arg His Leu Ile Ala Thr Gln Leu Leu Ser Asn Leu Glu Asp 
                325                 330                 335     


Ile Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro Phe Thr Tyr 
            340                 345                 350         


Ile Ser Pro Ser Asn Thr Glu Leu Thr Leu Met Ile Gln Glu Arg Gly 
        355                 360                 365             


Asp Lys Asn Val Thr Met Gly Gln Ser Ser Ala Arg Met Lys Leu Asn 
    370                 375                 380                 


Trp Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala Val Ala Gly 
385                 390                 395                 400 


Ile Leu Ser Ile Gln Asn Met Thr Thr Leu Leu Ala Asn Ala Ser Leu 
                405                 410                 415     


Asn Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile Tyr Glu Ser 
            420                 425                 430         


Ser Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val Asn Ser Ile 
        435                 440                 445             


Phe Leu Ser His Asn Asn Thr Lys Glu Leu Asn Ser Pro Ile Leu Phe 
    450                 455                 460                 


Ala Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly Arg Asp Pro 
465                 470                 475                 480 


Pro Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu Leu Cys Ala 
                485                 490                 495     


Phe Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala Thr Glu Gly 
            500                 505                 510         


Cys Gln Val Leu Gly Ser Lys Asn Gly Ser Thr Thr Cys Gln Cys Ser 
        515                 520                 525             


His Leu Ser Ser Phe Ala Ile Leu Met Ala His Tyr Asp Val Glu Asp 
    530                 535                 540                 


Trp Lys Leu Thr Leu Ile Thr Arg Val Gly Leu Ala Leu Ser Leu Phe 
545                 550                 555                 560 


Cys Leu Leu Leu Cys Ile Leu Thr Phe Leu Leu Val Arg Pro Ile Gln 
                565                 570                 575     


Gly Ser Arg Thr Thr Ile His Leu His Leu Cys Ile Cys Leu Phe Val 
            580                 585                 590         


Gly Ser Thr Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly Gly Gln Val 
        595                 600                 605             


Gly Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr Cys Phe Leu 
    610                 615                 620                 


Ala Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu Tyr Phe Leu 
625                 630                 635                 640 


Val Val Arg Val Phe Gln Gly Gln Gly Leu Ser Thr Arg Trp Leu Cys 
                645                 650                 655     


Leu Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val Ser Ala Ala 
            660                 665                 670         


Ile Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp Leu Asp Phe 
        675                 680                 685             


Glu Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Thr Phe Ile Ile 
    690                 695                 700                 


Leu Cys Asn Ala Val Ile Phe Val Thr Thr Val Trp Lys Leu Thr Gln 
705                 710                 715                 720 


Lys Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys Lys Ala Arg 
                725                 730                 735     


Ala Leu Thr Ile Thr Ala Ile Ala Gln Leu Phe Leu Leu Gly Cys Thr 
            740                 745                 750         


Trp Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu Val Leu Thr 
        755                 760                 765             


Tyr Val Phe Thr Ile Leu Asn Cys Leu Gln Gly Ala Phe Leu Tyr Leu 
    770                 775                 780                 


Leu His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr Arg Lys Trp 
785                 790                 795                 800 


Ala Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe Thr Ser Thr 
                805                 810                 815     


Thr Ser Gly Thr Gly His Asn Gln Thr Arg Ala Leu Arg Ala Ser Glu 
            820                 825                 830         


Ser Gly Ile 
        835 


<210>  139
<211>  821
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Asp Leu Ala Ala Ala Ala Glu Pro Gly Ala Gly Ser Gln His Leu 
1               5                   10                  15      


Glu Val Arg Asp Glu Val Ala Glu Lys Cys Gln Lys Leu Phe Leu Asp 
            20                  25                  30          


Phe Leu Glu Glu Phe Gln Ser Ser Asp Gly Glu Ile Lys Tyr Leu Gln 
        35                  40                  45              


Leu Ala Glu Glu Leu Ile Arg Pro Glu Arg Asn Thr Leu Val Val Ser 
    50                  55                  60                  


Phe Val Asp Leu Glu Gln Phe Asn Gln Gln Leu Ser Thr Thr Ile Gln 
65                  70                  75                  80  


Glu Glu Phe Tyr Arg Val Tyr Pro Tyr Leu Cys Arg Ala Leu Lys Thr 
                85                  90                  95      


Phe Val Lys Asp Arg Lys Glu Ile Pro Leu Ala Lys Asp Phe Tyr Val 
            100                 105                 110         


Ala Phe Gln Asp Leu Pro Thr Arg His Lys Ile Arg Glu Leu Thr Ser 
        115                 120                 125             


Ser Arg Ile Gly Leu Leu Thr Arg Ile Ser Gly Gln Val Val Arg Thr 
    130                 135                 140                 


His Pro Val His Pro Glu Leu Val Ser Gly Thr Phe Leu Cys Leu Asp 
145                 150                 155                 160 


Cys Gln Thr Val Ile Arg Asp Val Glu Gln Gln Phe Lys Tyr Thr Gln 
                165                 170                 175     


Pro Asn Ile Cys Arg Asn Pro Val Cys Ala Asn Arg Arg Arg Phe Leu 
            180                 185                 190         


Leu Asp Thr Asn Lys Ser Arg Phe Val Asp Phe Gln Lys Val Arg Ile 
        195                 200                 205             


Gln Glu Thr Gln Ala Glu Leu Pro Arg Gly Ser Ile Pro Arg Ser Leu 
    210                 215                 220                 


Glu Val Ile Leu Arg Ala Glu Ala Val Glu Ser Ala Gln Ala Gly Asp 
225                 230                 235                 240 


Lys Cys Asp Phe Thr Gly Thr Leu Ile Val Val Pro Asp Val Ser Lys 
                245                 250                 255     


Leu Ser Thr Pro Gly Ala Arg Ala Glu Thr Asn Ser Arg Val Ser Gly 
            260                 265                 270         


Val Asp Gly Tyr Glu Thr Glu Gly Ile Arg Gly Leu Arg Ala Leu Gly 
        275                 280                 285             


Val Arg Asp Leu Ser Tyr Arg Leu Val Phe Leu Ala Cys Cys Val Ala 
    290                 295                 300                 


Pro Thr Asn Pro Arg Phe Gly Gly Lys Glu Leu Arg Asp Glu Glu Gln 
305                 310                 315                 320 


Thr Ala Glu Ser Ile Lys Asn Gln Met Thr Val Lys Glu Trp Glu Lys 
                325                 330                 335     


Val Phe Glu Met Ser Gln Asp Lys Asn Leu Tyr His Asn Leu Cys Thr 
            340                 345                 350         


Ser Leu Phe Pro Thr Ile His Gly Asn Asp Glu Val Lys Arg Gly Val 
        355                 360                 365             


Leu Leu Met Leu Phe Gly Gly Val Pro Lys Thr Thr Gly Glu Gly Thr 
    370                 375                 380                 


Ser Leu Arg Gly Asp Ile Asn Val Cys Ile Val Gly Asp Pro Ser Thr 
385                 390                 395                 400 


Ala Lys Ser Gln Phe Leu Lys His Val Glu Glu Phe Ser Pro Arg Ala 
                405                 410                 415     


Val Tyr Thr Ser Gly Lys Ala Ser Ser Ala Ala Gly Leu Thr Ala Ala 
            420                 425                 430         


Val Val Arg Asp Glu Glu Ser His Glu Phe Val Ile Glu Ala Gly Ala 
        435                 440                 445             


Leu Met Leu Ala Asp Asn Gly Val Cys Cys Ile Asp Glu Phe Asp Lys 
    450                 455                 460                 


Met Asp Val Arg Asp Gln Val Ala Ile His Glu Ala Met Glu Gln Gln 
465                 470                 475                 480 


Thr Ile Ser Ile Thr Lys Ala Gly Val Lys Ala Thr Leu Asn Ala Arg 
                485                 490                 495     


Thr Ser Ile Leu Ala Ala Ala Asn Pro Ile Ser Gly His Tyr Asp Arg 
            500                 505                 510         


Ser Lys Ser Leu Lys Gln Asn Ile Asn Leu Ser Ala Pro Ile Met Ser 
        515                 520                 525             


Arg Phe Asp Leu Phe Phe Ile Leu Val Asp Glu Cys Asn Glu Val Thr 
    530                 535                 540                 


Asp Tyr Ala Ile Ala Arg Arg Ile Val Asp Leu His Ser Arg Ile Glu 
545                 550                 555                 560 


Glu Ser Ile Asp Arg Val Tyr Ser Leu Asp Asp Ile Arg Arg Tyr Leu 
                565                 570                 575     


Leu Phe Ala Arg Gln Phe Lys Pro Lys Ile Ser Lys Glu Ser Glu Asp 
            580                 585                 590         


Phe Ile Val Glu Gln Tyr Lys His Leu Arg Gln Arg Asp Gly Ser Gly 
        595                 600                 605             


Val Thr Lys Ser Ser Trp Arg Ile Thr Val Arg Gln Leu Glu Ser Met 
    610                 615                 620                 


Ile Arg Leu Ser Glu Ala Met Ala Arg Met His Cys Cys Asp Glu Val 
625                 630                 635                 640 


Gln Pro Lys His Val Lys Glu Ala Phe Arg Leu Leu Asn Lys Ser Ile 
                645                 650                 655     


Ile Arg Val Glu Thr Pro Asp Val Asn Leu Asp Gln Glu Glu Glu Ile 
            660                 665                 670         


Gln Met Glu Val Asp Glu Gly Ala Gly Gly Ile Asn Gly His Ala Asp 
        675                 680                 685             


Ser Pro Ala Pro Val Asn Gly Ile Asn Gly Tyr Asn Glu Asp Ile Asn 
    690                 695                 700                 


Gln Glu Ser Ala Pro Lys Ala Ser Leu Arg Leu Gly Phe Ser Glu Tyr 
705                 710                 715                 720 


Cys Arg Ile Ser Asn Leu Ile Val Leu His Leu Arg Lys Val Glu Glu 
                725                 730                 735     


Glu Glu Asp Glu Ser Ala Leu Lys Arg Ser Glu Leu Val Asn Trp Tyr 
            740                 745                 750         


Leu Lys Glu Ile Glu Ser Glu Ile Asp Ser Glu Glu Glu Leu Ile Asn 
        755                 760                 765             


Lys Lys Arg Ile Ile Glu Lys Val Ile His Arg Leu Thr His Tyr Asp 
    770                 775                 780                 


His Val Leu Ile Glu Leu Thr Gln Ala Gly Leu Lys Gly Ser Thr Glu 
785                 790                 795                 800 


Gly Ser Glu Ser Tyr Glu Glu Asp Pro Tyr Leu Val Val Asn Pro Asn 
                805                 810                 815     


Tyr Leu Leu Glu Asp 
            820     


<210>  140
<211>  863
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Ser Ser Pro Ala Ser Thr Pro Ser Arg Arg Gly Ser Arg Arg Gly 
1               5                   10                  15      


Arg Ala Thr Pro Ala Gln Thr Pro Arg Ser Glu Asp Ala Arg Ser Ser 
            20                  25                  30          


Pro Ser Gln Arg Arg Arg Gly Glu Asp Ser Thr Ser Thr Gly Glu Leu 
        35                  40                  45              


Gln Pro Met Pro Thr Ser Pro Gly Val Asp Leu Gln Ser Pro Ala Ala 
    50                  55                  60                  


Gln Asp Val Leu Phe Ser Ser Pro Pro Gln Met His Ser Ser Ala Ile 
65                  70                  75                  80  


Pro Leu Asp Phe Asp Val Ser Ser Pro Leu Thr Tyr Gly Thr Pro Ser 
                85                  90                  95      


Ser Arg Val Glu Gly Thr Pro Arg Ser Gly Val Arg Gly Thr Pro Val 
            100                 105                 110         


Arg Gln Arg Pro Asp Leu Gly Ser Ala Gln Lys Gly Leu Gln Val Asp 
        115                 120                 125             


Leu Gln Ser Asp Gly Ala Ala Ala Glu Asp Ile Val Ala Ser Glu Gln 
    130                 135                 140                 


Ser Leu Gly Gln Lys Leu Val Ile Trp Gly Thr Asp Val Asn Val Ala 
145                 150                 155                 160 


Ala Cys Lys Glu Asn Phe Gln Arg Phe Leu Gln Arg Phe Ile Asp Pro 
                165                 170                 175     


Leu Ala Lys Glu Glu Glu Asn Val Gly Ile Asp Ile Thr Glu Pro Leu 
            180                 185                 190         


Tyr Met Gln Arg Leu Gly Glu Ile Asn Val Ile Gly Glu Pro Phe Leu 
        195                 200                 205             


Asn Val Asn Cys Glu His Ile Lys Ser Phe Asp Lys Asn Leu Tyr Arg 
    210                 215                 220                 


Gln Leu Ile Ser Tyr Pro Gln Glu Val Ile Pro Thr Phe Asp Met Ala 
225                 230                 235                 240 


Val Asn Glu Ile Phe Phe Asp Arg Tyr Pro Asp Ser Ile Leu Glu His 
                245                 250                 255     


Gln Ile Gln Val Arg Pro Phe Asn Ala Leu Lys Thr Lys Asn Met Arg 
            260                 265                 270         


Asn Leu Asn Pro Glu Asp Ile Asp Gln Leu Ile Thr Ile Ser Gly Met 
        275                 280                 285             


Val Ile Arg Thr Ser Gln Leu Ile Pro Glu Met Gln Glu Ala Phe Phe 
    290                 295                 300                 


Gln Cys Gln Val Cys Ala His Thr Thr Arg Val Glu Met Asp Arg Gly 
305                 310                 315                 320 


Arg Ile Ala Glu Pro Ser Val Cys Gly Arg Cys His Thr Thr His Ser 
                325                 330                 335     


Met Ala Leu Ile His Asn Arg Ser Leu Phe Ser Asp Lys Gln Met Ile 
            340                 345                 350         


Lys Leu Gln Glu Ser Pro Glu Asp Met Pro Ala Gly Gln Thr Pro His 
        355                 360                 365             


Thr Val Ile Leu Phe Ala His Asn Asp Leu Val Asp Lys Val Gln Pro 
    370                 375                 380                 


Gly Asp Arg Val Asn Val Thr Gly Ile Tyr Arg Ala Val Pro Ile Arg 
385                 390                 395                 400 


Val Asn Pro Arg Val Ser Asn Val Lys Ser Val Tyr Lys Thr His Ile 
                405                 410                 415     


Asp Val Ile His Tyr Arg Lys Thr Asp Ala Lys Arg Leu His Gly Leu 
            420                 425                 430         


Asp Glu Glu Ala Glu Gln Lys Leu Phe Ser Glu Lys Arg Val Glu Leu 
        435                 440                 445             


Leu Lys Glu Leu Ser Arg Lys Pro Asp Ile Tyr Glu Arg Leu Ala Ser 
    450                 455                 460                 


Ala Leu Ala Pro Ser Ile Tyr Glu His Glu Asp Ile Lys Lys Gly Ile 
465                 470                 475                 480 


Leu Leu Gln Leu Phe Gly Gly Thr Arg Lys Asp Phe Ser His Thr Gly 
                485                 490                 495     


Arg Gly Lys Phe Arg Ala Glu Ile Asn Ile Leu Leu Cys Gly Asp Pro 
            500                 505                 510         


Gly Thr Ser Lys Ser Gln Leu Leu Gln Tyr Val Tyr Asn Leu Val Pro 
        515                 520                 525             


Arg Gly Gln Tyr Thr Ser Gly Lys Gly Ser Ser Ala Val Gly Leu Thr 
    530                 535                 540                 


Ala Tyr Val Met Lys Asp Pro Glu Thr Arg Gln Leu Val Leu Gln Thr 
545                 550                 555                 560 


Gly Ala Leu Val Leu Ser Asp Asn Gly Ile Cys Cys Ile Asp Glu Phe 
                565                 570                 575     


Asp Lys Met Asn Glu Ser Thr Arg Ser Val Leu His Glu Val Met Glu 
            580                 585                 590         


Gln Gln Thr Leu Ser Ile Ala Lys Ala Gly Ile Ile Cys Gln Leu Asn 
        595                 600                 605             


Ala Arg Thr Ser Val Leu Ala Ala Ala Asn Pro Ile Glu Ser Gln Trp 
    610                 615                 620                 


Asn Pro Lys Lys Thr Thr Ile Glu Asn Ile Gln Leu Pro His Thr Leu 
625                 630                 635                 640 


Leu Ser Arg Phe Asp Leu Ile Phe Leu Leu Leu Asp Pro Gln Asp Glu 
                645                 650                 655     


Ala Tyr Asp Arg Arg Leu Ala His His Leu Val Ala Leu Tyr Tyr Gln 
            660                 665                 670         


Ser Glu Glu Gln Ala Glu Glu Glu Leu Leu Asp Met Ala Val Leu Lys 
        675                 680                 685             


Asp Tyr Ile Ala Tyr Ala His Ser Thr Ile Met Pro Arg Leu Ser Glu 
    690                 695                 700                 


Glu Ala Ser Gln Ala Leu Ile Glu Ala Tyr Val Asp Met Arg Lys Ile 
705                 710                 715                 720 


Gly Ser Ser Arg Gly Met Val Ser Ala Tyr Pro Arg Gln Leu Glu Ser 
                725                 730                 735     


Leu Ile Arg Leu Ala Glu Ala His Ala Lys Val Arg Leu Ser Asn Lys 
            740                 745                 750         


Val Glu Ala Ile Asp Val Glu Glu Ala Lys Arg Leu His Arg Glu Ala 
        755                 760                 765             


Leu Lys Gln Ser Ala Thr Asp Pro Arg Thr Gly Ile Val Asp Ile Ser 
    770                 775                 780                 


Ile Leu Thr Thr Gly Met Ser Ala Thr Ser Arg Lys Arg Lys Glu Glu 
785                 790                 795                 800 


Leu Ala Glu Ala Leu Lys Lys Leu Ile Leu Ser Lys Gly Lys Thr Pro 
                805                 810                 815     


Ala Leu Lys Tyr Gln Gln Leu Phe Glu Asp Ile Arg Gly Gln Ser Asp 
            820                 825                 830         


Ile Ala Ile Thr Lys Asp Met Phe Glu Glu Ala Leu Arg Ala Leu Ala 
        835                 840                 845             


Asp Asp Asp Phe Leu Thr Val Thr Gly Lys Thr Val Arg Leu Leu 
    850                 855                 860             


<210>  141
<211>  770
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Ser Asn Glu Val Glu Thr Ser Ala Thr Asn Gly Gln Pro Asp Gln 
1               5                   10                  15      


Gln Ala Ala Pro Lys Ala Pro Ser Lys Lys Glu Lys Lys Lys Gly Pro 
            20                  25                  30          


Glu Lys Thr Asp Glu Tyr Leu Leu Ala Arg Phe Lys Gly Asp Gly Val 
        35                  40                  45              


Lys Tyr Lys Ala Lys Leu Ile Gly Ile Asp Asp Val Pro Asp Ala Arg 
    50                  55                  60                  


Gly Asp Lys Met Ser Gln Asp Ser Met Met Lys Leu Lys Gly Met Ala 
65                  70                  75                  80  


Ala Ala Gly Arg Ser Gln Gly Gln His Lys Gln Arg Ile Trp Val Asn 
                85                  90                  95      


Ile Ser Leu Ser Gly Ile Lys Ile Ile Asp Glu Lys Thr Gly Val Ile 
            100                 105                 110         


Glu His Glu His Pro Val Asn Lys Ile Ser Phe Ile Ala Arg Asp Val 
        115                 120                 125             


Thr Asp Asn Arg Ala Phe Gly Tyr Val Cys Gly Gly Glu Gly Gln His 
    130                 135                 140                 


Gln Phe Phe Ala Ile Lys Thr Gly Gln Gln Ala Glu Pro Leu Val Val 
145                 150                 155                 160 


Asp Leu Lys Asp Leu Phe Gln Val Ile Tyr Asn Val Lys Lys Lys Glu 
                165                 170                 175     


Glu Glu Lys Lys Lys Ile Glu Glu Ala Ser Lys Ala Val Glu Asn Gly 
            180                 185                 190         


Ser Glu Ala Leu Met Ile Leu Asp Asp Gln Thr Asn Lys Leu Lys Ser 
        195                 200                 205             


Gly Val Asp Gln Met Asp Leu Phe Gly Asp Met Ser Thr Pro Pro Asp 
    210                 215                 220                 


Leu Asn Ser Pro Thr Glu Ser Lys Asp Ile Leu Leu Val Asp Leu Asn 
225                 230                 235                 240 


Ser Glu Ile Asp Thr Asn Gln Asn Ser Leu Arg Glu Asn Pro Phe Leu 
                245                 250                 255     


Thr Asn Gly Ile Thr Ser Cys Ser Leu Pro Arg Pro Thr Pro Gln Ala 
            260                 265                 270         


Ser Phe Leu Pro Glu Asn Ala Phe Ser Ala Asn Leu Asn Phe Phe Pro 
        275                 280                 285             


Thr Pro Asn Pro Asp Pro Phe Arg Asp Asp Pro Phe Thr Gln Pro Asp 
    290                 295                 300                 


Gln Ser Thr Pro Ser Ser Phe Asp Ser Leu Lys Ser Pro Asp Gln Lys 
305                 310                 315                 320 


Lys Glu Asn Ser Ser Ser Ser Ser Thr Pro Leu Ser Asn Gly Pro Leu 
                325                 330                 335     


Asn Gly Asp Val Asp Tyr Phe Gly Gln Gln Phe Asp Gln Ile Ser Asn 
            340                 345                 350         


Arg Thr Gly Lys Gln Glu Ala Gln Ala Gly Pro Trp Pro Phe Ser Ser 
        355                 360                 365             


Ser Gln Thr Gln Pro Ala Val Arg Thr Gln Asn Gly Val Ser Glu Arg 
    370                 375                 380                 


Glu Gln Asn Gly Phe Ser Val Lys Ser Ser Pro Asn Pro Phe Val Gly 
385                 390                 395                 400 


Ser Pro Pro Lys Gly Leu Ser Ile Gln Asn Gly Val Lys Gln Asp Leu 
                405                 410                 415     


Glu Ser Ser Val Gln Ser Ser Pro His Asp Ser Ile Ala Ile Ile Pro 
            420                 425                 430         


Pro Pro Gln Ser Thr Lys Pro Gly Arg Gly Arg Arg Thr Ala Lys Ser 
        435                 440                 445             


Ser Ala Asn Asp Leu Leu Ala Ser Asp Ile Phe Ala Pro Pro Val Ser 
    450                 455                 460                 


Glu Pro Ser Gly Gln Ala Ser Pro Thr Gly Gln Pro Thr Ala Leu Gln 
465                 470                 475                 480 


Pro Asn Pro Leu Asp Leu Phe Lys Thr Ser Ala Pro Ala Pro Val Gly 
                485                 490                 495     


Pro Leu Val Gly Leu Gly Gly Val Thr Val Thr Leu Pro Gln Ala Gly 
            500                 505                 510         


Pro Trp Asn Thr Ala Ser Leu Val Phe Asn Gln Ser Pro Ser Met Ala 
        515                 520                 525             


Pro Gly Ala Met Met Gly Gly Gln Pro Ser Gly Phe Ser Gln Pro Val 
    530                 535                 540                 


Ile Phe Gly Thr Ser Pro Ala Val Ser Gly Trp Asn Gln Pro Ser Pro 
545                 550                 555                 560 


Phe Ala Ala Ser Thr Pro Pro Pro Val Pro Val Val Trp Gly Pro Ser 
                565                 570                 575     


Ala Ser Val Ala Pro Asn Ala Trp Ser Thr Thr Ser Pro Leu Gly Asn 
            580                 585                 590         


Pro Phe Gln Ser Asn Ile Phe Pro Ala Pro Ala Val Ser Thr Gln Pro 
        595                 600                 605             


Pro Ser Met His Ser Ser Leu Leu Val Thr Pro Pro Gln Pro Pro Pro 
    610                 615                 620                 


Arg Ala Gly Pro Pro Lys Asp Ile Ser Ser Asp Ala Phe Thr Ala Leu 
625                 630                 635                 640 


Asp Pro Leu Gly Asp Lys Glu Ile Lys Asp Val Lys Glu Met Phe Lys 
                645                 650                 655     


Asp Phe Gln Leu Arg Gln Pro Pro Ala Val Pro Ala Arg Lys Gly Glu 
            660                 665                 670         


Gln Thr Ser Ser Gly Thr Leu Ser Ala Phe Ala Ser Tyr Phe Asn Ser 
        675                 680                 685             


Lys Val Gly Ile Pro Gln Glu Asn Ala Asp His Asp Asp Phe Asp Ala 
    690                 695                 700                 


Asn Gln Leu Leu Asn Lys Ile Asn Glu Pro Pro Lys Pro Ala Pro Arg 
705                 710                 715                 720 


Gln Val Ser Leu Pro Val Thr Lys Ser Thr Asp Asn Ala Phe Glu Asn 
                725                 730                 735     


Pro Phe Phe Lys Asp Ser Phe Gly Ser Ser Gln Ala Ser Val Ala Ser 
            740                 745                 750         


Ser Gln Pro Val Ser Ser Glu Met Tyr Arg Asp Pro Phe Gly Asn Pro 
        755                 760                 765             


Phe Ala 
    770 


<210>  142
<211>  1309
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Leu Leu Asn Gly Asp Cys Pro Glu Ser Leu Lys Lys Glu Ala Ala 
1               5                   10                  15      


Ala Ala Glu Pro Pro Arg Glu Asn Gly Leu Asp Glu Ala Gly Pro Gly 
            20                  25                  30          


Asp Glu Thr Thr Gly Gln Glu Val Ile Val Ile Gln Asp Thr Gly Phe 
        35                  40                  45              


Ser Val Lys Ile Leu Ala Pro Gly Ile Glu Pro Phe Ser Leu Gln Val 
    50                  55                  60                  


Ser Pro Gln Glu Met Val Gln Glu Ile His Gln Val Leu Met Asp Arg 
65                  70                  75                  80  


Glu Asp Thr Cys His Arg Thr Cys Phe Ser Leu His Leu Asp Gly Asn 
                85                  90                  95      


Val Leu Asp His Phe Ser Glu Leu Arg Ser Val Glu Gly Leu Gln Glu 
            100                 105                 110         


Gly Ser Val Leu Arg Val Val Glu Glu Pro Tyr Thr Val Arg Glu Ala 
        115                 120                 125             


Arg Ile His Val Arg His Val Arg Asp Leu Leu Lys Ser Leu Asp Pro 
    130                 135                 140                 


Ser Asp Ala Phe Asn Gly Val Asp Cys Asn Ser Leu Ser Phe Leu Ser 
145                 150                 155                 160 


Val Phe Thr Asp Gly Asp Leu Gly Asp Ser Gly Lys Arg Lys Lys Gly 
                165                 170                 175     


Leu Glu Met Asp Pro Ile Asp Cys Thr Pro Pro Glu Tyr Ile Leu Pro 
            180                 185                 190         


Gly Ser Arg Glu Arg Pro Leu Cys Pro Leu Gln Pro Gln Asn Arg Asp 
        195                 200                 205             


Trp Lys Pro Leu Gln Cys Leu Lys Val Leu Thr Met Ser Gly Trp Asn 
    210                 215                 220                 


Pro Pro Pro Gly Asn Arg Lys Met His Gly Asp Leu Met Tyr Leu Phe 
225                 230                 235                 240 


Val Ile Thr Ala Glu Asp Arg Gln Val Ser Ile Thr Ala Ser Thr Arg 
                245                 250                 255     


Gly Phe Tyr Leu Asn Gln Ser Thr Ala Tyr His Phe Asn Pro Lys Pro 
            260                 265                 270         


Ala Ser Pro Arg Phe Leu Ser His Ser Leu Val Glu Leu Leu Asn Gln 
        275                 280                 285             


Ile Ser Pro Thr Phe Lys Lys Asn Phe Ala Val Leu Gln Lys Lys Arg 
    290                 295                 300                 


Val Gln Arg His Pro Phe Glu Arg Ile Ala Thr Pro Phe Gln Val Tyr 
305                 310                 315                 320 


Ser Trp Thr Ala Pro Gln Ala Glu His Ala Met Asp Cys Val Arg Ala 
                325                 330                 335     


Glu Asp Ala Tyr Thr Ser Arg Leu Gly Tyr Glu Glu His Ile Pro Gly 
            340                 345                 350         


Gln Thr Arg Asp Trp Asn Glu Glu Leu Gln Thr Thr Arg Glu Leu Pro 
        355                 360                 365             


Arg Lys Asn Leu Pro Glu Arg Leu Leu Arg Glu Arg Ala Ile Phe Lys 
    370                 375                 380                 


Val His Ser Asp Phe Thr Ala Ala Ala Thr Arg Gly Ala Met Ala Val 
385                 390                 395                 400 


Ile Asp Gly Asn Val Met Ala Ile Asn Pro Ser Glu Glu Thr Lys Met 
                405                 410                 415     


Gln Met Phe Ile Trp Asn Asn Ile Phe Phe Ser Leu Gly Phe Asp Val 
            420                 425                 430         


Arg Asp His Tyr Lys Asp Phe Gly Gly Asp Val Ala Ala Tyr Val Ala 
        435                 440                 445             


Pro Thr Asn Asp Leu Asn Gly Val Arg Thr Tyr Asn Ala Val Asp Val 
    450                 455                 460                 


Glu Gly Leu Tyr Thr Leu Gly Thr Val Val Val Asp Tyr Arg Gly Tyr 
465                 470                 475                 480 


Arg Val Thr Ala Gln Ser Ile Ile Pro Gly Ile Leu Glu Arg Asp Gln 
                485                 490                 495     


Glu Gln Ser Val Ile Tyr Gly Ser Ile Asp Phe Gly Lys Thr Val Val 
            500                 505                 510         


Ser His Pro Arg Tyr Leu Glu Leu Leu Glu Arg Thr Ser Arg Pro Leu 
        515                 520                 525             


Lys Ile Leu Arg His Gln Val Leu Asn Asp Arg Asp Glu Glu Val Glu 
    530                 535                 540                 


Leu Cys Ser Ser Val Glu Cys Lys Gly Ile Ile Gly Asn Asp Gly Arg 
545                 550                 555                 560 


His Tyr Ile Leu Asp Leu Leu Arg Thr Phe Pro Pro Asp Leu Asn Phe 
                565                 570                 575     


Leu Pro Val Pro Gly Glu Glu Leu Pro Glu Glu Cys Ala Arg Ala Gly 
            580                 585                 590         


Phe Pro Arg Ala His Arg His Lys Leu Cys Cys Leu Arg Gln Glu Leu 
        595                 600                 605             


Val Asp Ala Phe Val Glu His Arg Tyr Leu Leu Phe Met Lys Leu Ala 
    610                 615                 620                 


Ala Leu Gln Leu Met Gln Gln Asn Ala Ser Gln Leu Glu Thr Pro Ser 
625                 630                 635                 640 


Ser Leu Glu Asn Gly Gly Pro Ser Ser Leu Glu Ser Lys Ser Glu Asp 
                645                 650                 655     


Pro Pro Gly Gln Glu Ala Gly Ser Glu Glu Glu Gly Ser Ser Ala Ser 
            660                 665                 670         


Gly Leu Ala Lys Val Lys Glu Leu Ala Glu Thr Ile Ala Ala Asp Asp 
        675                 680                 685             


Gly Thr Asp Pro Arg Ser Arg Glu Val Ile Arg Asn Ala Cys Lys Ala 
    690                 695                 700                 


Val Gly Ser Ile Ser Ser Thr Ala Phe Asp Ile Arg Phe Asn Pro Asp 
705                 710                 715                 720 


Ile Phe Ser Pro Gly Val Arg Phe Pro Glu Ser Cys Gln Asp Glu Val 
                725                 730                 735     


Arg Asp Gln Lys Gln Leu Leu Lys Asp Ala Ala Ala Phe Leu Leu Ser 
            740                 745                 750         


Cys Gln Ile Pro Gly Leu Val Lys Asp Cys Met Glu His Ala Val Leu 
        755                 760                 765             


Pro Val Asp Gly Ala Thr Leu Ala Glu Val Met Arg Gln Arg Gly Ile 
    770                 775                 780                 


Asn Met Arg Tyr Leu Gly Lys Val Leu Glu Leu Val Leu Arg Ser Pro 
785                 790                 795                 800 


Ala Arg His Gln Leu Asp His Val Phe Lys Ile Gly Ile Gly Glu Leu 
                805                 810                 815     


Ile Thr Arg Ser Ala Lys His Ile Phe Lys Thr Tyr Leu Gln Gly Val 
            820                 825                 830         


Glu Leu Ser Gly Leu Ser Ala Ala Ile Ser His Phe Leu Asn Cys Phe 
        835                 840                 845             


Leu Ser Ser Tyr Pro Asn Pro Val Ala His Leu Pro Ala Asp Glu Leu 
    850                 855                 860                 


Val Ser Lys Lys Arg Asn Lys Arg Arg Lys Asn Arg Pro Pro Gly Ala 
865                 870                 875                 880 


Ala Asp Asn Thr Ala Trp Ala Val Met Thr Pro Gln Glu Leu Trp Lys 
                885                 890                 895     


Asn Ile Cys Gln Glu Ala Lys Asn Tyr Phe Asp Phe Asp Leu Glu Cys 
            900                 905                 910         


Glu Thr Val Asp Gln Ala Val Glu Thr Tyr Gly Leu Gln Lys Ile Thr 
        915                 920                 925             


Leu Leu Arg Glu Ile Ser Leu Lys Thr Gly Ile Gln Val Leu Leu Lys 
    930                 935                 940                 


Glu Tyr Ser Phe Asp Ser Arg His Lys Pro Ala Phe Thr Glu Glu Asp 
945                 950                 955                 960 


Val Leu Asn Ile Phe Pro Val Val Lys His Val Asn Pro Lys Ala Ser 
                965                 970                 975     


Asp Ala Phe His Phe Phe Gln Ser Gly Gln Ala Lys Val Gln Gln Gly 
            980                 985                 990         


Phe Leu Lys Glu Gly Cys Glu Leu  Ile Asn Glu Ala Leu  Asn Leu Phe 
        995                 1000                 1005             


Asn Asn  Val Tyr Gly Ala Met  His Val Glu Thr Cys  Ala Cys Leu 
    1010                 1015                 1020             


Arg Leu  Leu Ala Arg Leu His  Tyr Ile Met Gly Asp  Tyr Ala Glu 
    1025                 1030                 1035             


Ala Leu  Ser Asn Gln Gln Lys  Ala Val Leu Met Ser  Glu Arg Val 
    1040                 1045                 1050             


Met Gly  Thr Glu His Pro Asn  Thr Ile Gln Glu Tyr  Met His Leu 
    1055                 1060                 1065             


Ala Leu  Tyr Cys Phe Ala Ser  Ser Gln Leu Ser Thr  Ala Leu Ser 
    1070                 1075                 1080             


Leu Leu  Tyr Arg Ala Arg Tyr  Leu Met Leu Leu Val  Phe Gly Glu 
    1085                 1090                 1095             


Asp His  Pro Glu Met Ala Leu  Leu Asp Asn Asn Ile  Gly Leu Val 
    1100                 1105                 1110             


Leu His  Gly Val Met Glu Tyr  Asp Leu Ser Leu Arg  Phe Leu Glu 
    1115                 1120                 1125             


Asn Ala  Leu Ala Val Ser Thr  Lys Tyr His Gly Pro  Lys Ala Leu 
    1130                 1135                 1140             


Lys Val  Ala Leu Ser His His  Leu Val Ala Arg Val  Tyr Glu Ser 
    1145                 1150                 1155             


Lys Ala  Glu Phe Arg Ser Ala  Leu Gln His Glu Lys  Glu Gly Tyr 
    1160                 1165                 1170             


Thr Ile  Tyr Lys Thr Gln Leu  Gly Glu Asp His Glu  Lys Thr Lys 
    1175                 1180                 1185             


Glu Ser  Ser Glu Tyr Leu Lys  Cys Leu Thr Gln Gln  Ala Val Ala 
    1190                 1195                 1200             


Leu Gln  Arg Thr Met Asn Glu  Ile Tyr Arg Asn Gly  Ser Ser Ala 
    1205                 1210                 1215             


Asn Ile  Pro Pro Leu Lys Phe  Thr Ala Pro Ser Met  Ala Ser Val 
    1220                 1225                 1230             


Leu Glu  Gln Leu Asn Val Ile  Asn Gly Ile Leu Phe  Ile Pro Leu 
    1235                 1240                 1245             


Ser Gln  Lys Asp Leu Glu Asn  Leu Lys Ala Glu Val  Ala Arg Arg 
    1250                 1255                 1260             


His Gln  Leu Gln Glu Ala Ser  Arg Asn Arg Asp Arg  Ala Glu Glu 
    1265                 1270                 1275             


Pro Met  Ala Thr Glu Pro Ala  Pro Ala Gly Ala Pro  Gly Asp Leu 
    1280                 1285                 1290             


Gly Ser  Gln Pro Pro Ala Ala  Lys Asp Pro Ser Pro  Ser Val Gln 
    1295                 1300                 1305             


Gly 
    


<210>  143
<211>  904
<212>  PRT
<213>  Homo sapiens

<400>  143

Met Ala Glu Ser Ser Glu Ser Phe Thr Met Ala Ser Ser Pro Ala Gln 
1               5                   10                  15      


Arg Arg Arg Gly Asn Asp Pro Leu Thr Ser Ser Pro Gly Arg Ser Ser 
            20                  25                  30          


Arg Arg Thr Asp Ala Leu Thr Ser Ser Pro Gly Arg Asp Leu Pro Pro 
        35                  40                  45              


Phe Glu Asp Glu Ser Glu Gly Leu Leu Gly Thr Glu Gly Pro Leu Glu 
    50                  55                  60                  


Glu Glu Glu Asp Gly Glu Glu Leu Ile Gly Asp Gly Met Glu Arg Asp 
65                  70                  75                  80  


Tyr Arg Ala Ile Pro Glu Leu Asp Ala Tyr Glu Ala Glu Gly Leu Ala 
                85                  90                  95      


Leu Asp Asp Glu Asp Val Glu Glu Leu Thr Ala Ser Gln Arg Glu Ala 
            100                 105                 110         


Ala Glu Arg Ala Met Arg Gln Arg Asp Arg Glu Ala Gly Arg Gly Leu 
        115                 120                 125             


Gly Arg Met Arg Arg Gly Leu Leu Tyr Asp Ser Asp Glu Glu Asp Glu 
    130                 135                 140                 


Glu Arg Pro Ala Arg Lys Arg Arg Gln Val Glu Arg Ala Thr Glu Asp 
145                 150                 155                 160 


Gly Glu Glu Asp Glu Glu Met Ile Glu Ser Ile Glu Asn Leu Glu Asp 
                165                 170                 175     


Leu Lys Gly His Ser Val Arg Glu Trp Val Ser Met Ala Gly Pro Arg 
            180                 185                 190         


Leu Glu Ile His His Arg Phe Lys Asn Phe Leu Arg Thr His Val Asp 
        195                 200                 205             


Ser His Gly His Asn Val Phe Lys Glu Arg Ile Ser Asp Met Cys Lys 
    210                 215                 220                 


Glu Asn Arg Glu Ser Leu Val Val Asn Tyr Glu Asp Leu Ala Ala Arg 
225                 230                 235                 240 


Glu His Val Leu Ala Tyr Phe Leu Pro Glu Ala Pro Ala Glu Leu Leu 
                245                 250                 255     


Gln Ile Phe Asp Glu Ala Ala Leu Glu Val Val Leu Ala Met Tyr Pro 
            260                 265                 270         


Lys Tyr Asp Arg Ile Thr Asn His Ile His Val Arg Ile Ser His Leu 
        275                 280                 285             


Pro Leu Val Glu Glu Leu Arg Ser Leu Arg Gln Leu His Leu Asn Gln 
    290                 295                 300                 


Leu Ile Arg Thr Ser Gly Val Val Thr Ser Cys Thr Gly Val Leu Pro 
305                 310                 315                 320 


Gln Leu Ser Met Val Lys Tyr Asn Cys Asn Lys Cys Asn Phe Val Leu 
                325                 330                 335     


Gly Pro Phe Cys Gln Ser Gln Asn Gln Glu Val Lys Pro Gly Ser Cys 
            340                 345                 350         


Pro Glu Cys Gln Ser Ala Gly Pro Phe Glu Val Asn Met Glu Glu Thr 
        355                 360                 365             


Ile Tyr Gln Asn Tyr Gln Arg Ile Arg Ile Gln Glu Ser Pro Gly Lys 
    370                 375                 380                 


Val Ala Ala Gly Arg Leu Pro Arg Ser Lys Asp Ala Ile Leu Leu Ala 
385                 390                 395                 400 


Asp Leu Val Asp Ser Cys Lys Pro Gly Asp Glu Ile Glu Leu Thr Gly 
                405                 410                 415     


Ile Tyr His Asn Asn Tyr Asp Gly Ser Leu Asn Thr Ala Asn Gly Phe 
            420                 425                 430         


Pro Val Phe Ala Thr Val Ile Leu Ala Asn His Val Ala Lys Lys Asp 
        435                 440                 445             


Asn Lys Val Ala Val Gly Glu Leu Thr Asp Glu Asp Val Lys Met Ile 
    450                 455                 460                 


Thr Ser Leu Ser Lys Asp Gln Gln Ile Gly Glu Lys Ile Phe Ala Ser 
465                 470                 475                 480 


Ile Ala Pro Ser Ile Tyr Gly His Glu Asp Ile Lys Arg Gly Leu Ala 
                485                 490                 495     


Leu Ala Leu Phe Gly Gly Glu Pro Lys Asn Pro Gly Gly Lys His Lys 
            500                 505                 510         


Val Arg Gly Asp Ile Asn Val Leu Leu Cys Gly Asp Pro Gly Thr Ala 
        515                 520                 525             


Lys Ser Gln Phe Leu Lys Tyr Ile Glu Lys Val Ser Ser Arg Ala Ile 
    530                 535                 540                 


Phe Thr Thr Gly Gln Gly Ala Ser Ala Val Gly Leu Thr Ala Tyr Val 
545                 550                 555                 560 


Gln Arg His Pro Val Ser Arg Glu Trp Thr Leu Glu Ala Gly Ala Leu 
                565                 570                 575     


Val Leu Ala Asp Arg Gly Val Cys Leu Ile Asp Glu Phe Asp Lys Met 
            580                 585                 590         


Asn Asp Gln Asp Arg Thr Ser Ile His Glu Ala Met Glu Gln Gln Ser 
        595                 600                 605             


Ile Ser Ile Ser Lys Ala Gly Ile Val Thr Ser Leu Gln Ala Arg Cys 
    610                 615                 620                 


Thr Val Ile Ala Ala Ala Asn Pro Ile Gly Gly Arg Tyr Asp Pro Ser 
625                 630                 635                 640 


Leu Thr Phe Ser Glu Asn Val Asp Leu Thr Glu Pro Ile Ile Ser Arg 
                645                 650                 655     


Phe Asp Ile Leu Cys Val Val Arg Asp Thr Val Asp Pro Val Gln Asp 
            660                 665                 670         


Glu Met Leu Ala Arg Phe Val Val Gly Ser His Val Arg His His Pro 
        675                 680                 685             


Ser Asn Lys Glu Glu Glu Gly Leu Ala Asn Gly Ser Ala Ala Glu Pro 
    690                 695                 700                 


Ala Met Pro Asn Thr Tyr Gly Val Glu Pro Leu Pro Gln Glu Val Leu 
705                 710                 715                 720 


Lys Lys Tyr Ile Ile Tyr Ala Lys Glu Arg Val His Pro Lys Leu Asn 
                725                 730                 735     


Gln Met Asp Gln Asp Lys Val Ala Lys Met Tyr Ser Asp Leu Arg Lys 
            740                 745                 750         


Glu Ser Met Ala Thr Gly Ser Ile Pro Ile Thr Val Arg His Ile Glu 
        755                 760                 765             


Ser Met Ile Arg Met Ala Glu Ala His Ala Arg Ile His Leu Arg Asp 
    770                 775                 780                 


Tyr Val Ile Glu Asp Asp Val Asn Met Ala Ile Arg Val Met Leu Glu 
785                 790                 795                 800 


Ser Phe Ile Asp Thr Gln Lys Phe Ser Val Met Arg Ser Met Arg Lys 
                805                 810                 815     


Thr Phe Ala Arg Tyr Leu Ser Phe Arg Arg Asp Asn Asn Glu Leu Leu 
            820                 825                 830         


Leu Phe Ile Leu Lys Gln Leu Val Ala Glu Gln Val Thr Tyr Gln Arg 
        835                 840                 845             


Asn Arg Phe Gly Ala Gln Gln Asp Thr Ile Glu Val Pro Glu Lys Asp 
    850                 855                 860                 


Leu Val Asp Lys Ala Arg Gln Ile Asn Ile His Asn Leu Ser Ala Phe 
865                 870                 875                 880 


Tyr Asp Ser Glu Leu Phe Arg Met Asn Lys Phe Ser His Asp Leu Lys 
                885                 890                 895     


Arg Lys Met Ile Leu Gln Gln Phe 
            900                 


<210>  144
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Arg Phe Ala Trp Thr Val Leu Leu Leu Gly Pro Leu Gln Leu Cys 
1               5                   10                  15      


Ala Leu Val His Cys Ala Pro Pro Ala Ala Gly Gln Gln Gln Pro Pro 
            20                  25                  30          


Arg Glu Pro Pro Ala Ala Pro Gly Ala Trp Arg Gln Gln Ile Gln Trp 
        35                  40                  45              


Glu Asn Asn Gly Gln Val Phe Ser Leu Leu Ser Leu Gly Ser Gln Tyr 
    50                  55                  60                  


Gln Pro Gln Arg Arg Arg Asp Pro Gly Ala Ala Val Pro Gly Ala Ala 
65                  70                  75                  80  


Asn Ala Ser Ala Gln Gln Pro Arg Thr Pro Ile Leu Leu Ile Arg Asp 
                85                  90                  95      


Asn Arg Thr Ala Ala Ala Arg Thr Arg Thr Ala Gly Ser Ser Gly Val 
            100                 105                 110         


Thr Ala Gly Arg Pro Arg Pro Thr Ala Arg His Trp Phe Gln Ala Gly 
        115                 120                 125             


Tyr Ser Thr Ser Arg Ala Arg Glu Ala Gly Ala Ser Arg Ala Glu Asn 
    130                 135                 140                 


Gln Thr Ala Pro Gly Glu Val Pro Ala Leu Ser Asn Leu Arg Pro Pro 
145                 150                 155                 160 


Ser Arg Val Asp Gly Met Val Gly Asp Asp Pro Tyr Asn Pro Tyr Lys 
                165                 170                 175     


Tyr Ser Asp Asp Asn Pro Tyr Tyr Asn Tyr Tyr Asp Thr Tyr Glu Arg 
            180                 185                 190         


Pro Arg Pro Gly Gly Arg Tyr Arg Pro Gly Tyr Gly Thr Gly Tyr Phe 
        195                 200                 205             


Gln Tyr Gly Leu Pro Asp Leu Val Ala Asp Pro Tyr Tyr Ile Gln Ala 
    210                 215                 220                 


Ser Thr Tyr Val Gln Lys Met Ser Met Tyr Asn Leu Arg Cys Ala Ala 
225                 230                 235                 240 


Glu Glu Asn Cys Leu Ala Ser Thr Ala Tyr Arg Ala Asp Val Arg Asp 
                245                 250                 255     


Tyr Asp His Arg Val Leu Leu Arg Phe Pro Gln Arg Val Lys Asn Gln 
            260                 265                 270         


Gly Thr Ser Asp Phe Leu Pro Ser Arg Pro Arg Tyr Ser Trp Glu Trp 
        275                 280                 285             


His Ser Cys His Gln His Tyr His Ser Met Asp Glu Phe Ser His Tyr 
    290                 295                 300                 


Asp Leu Leu Asp Ala Asn Thr Gln Arg Arg Val Ala Glu Gly His Lys 
305                 310                 315                 320 


Ala Ser Phe Cys Leu Glu Asp Thr Ser Cys Asp Tyr Gly Tyr His Arg 
                325                 330                 335     


Arg Phe Ala Cys Thr Ala His Thr Gln Gly Leu Ser Pro Gly Cys Tyr 
            340                 345                 350         


Asp Thr Tyr Gly Ala Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp 
        355                 360                 365             


Val Lys Pro Gly Asn Tyr Ile Leu Lys Val Ser Val Asn Pro Ser Tyr 
    370                 375                 380                 


Leu Val Pro Glu Ser Asp Tyr Thr Asn Asn Val Val Arg Cys Asp Ile 
385                 390                 395                 400 


Arg Tyr Thr Gly His His Ala Tyr Ala Ser Gly Cys Thr Ile Ser Pro 
                405                 410                 415     


Tyr 
    


<210>  145
<211>  792
<212>  PRT
<213>  Homo sapiens

<400>  145

Met His Val Ile Lys Arg Asp Gly Arg Gln Glu Arg Val Met Phe Asp 
1               5                   10                  15      


Lys Ile Thr Ser Arg Ile Gln Lys Leu Cys Tyr Gly Leu Asn Met Asp 
            20                  25                  30          


Phe Val Asp Pro Ala Gln Ile Thr Met Lys Val Ile Gln Gly Leu Tyr 
        35                  40                  45              


Ser Gly Val Thr Thr Val Glu Leu Asp Thr Leu Ala Ala Glu Thr Ala 
    50                  55                  60                  


Ala Thr Leu Thr Thr Lys His Pro Asp Tyr Ala Ile Leu Ala Ala Arg 
65                  70                  75                  80  


Ile Ala Val Ser Asn Leu His Lys Glu Thr Lys Lys Val Phe Ser Asp 
                85                  90                  95      


Val Met Glu Asp Leu Tyr Asn Tyr Ile Asn Pro His Asn Gly Lys His 
            100                 105                 110         


Ser Pro Met Val Ala Lys Ser Thr Leu Asp Ile Val Leu Ala Asn Lys 
        115                 120                 125             


Asp Arg Leu Asn Ser Ala Ile Ile Tyr Asp Arg Asp Phe Ser Tyr Asn 
    130                 135                 140                 


Tyr Phe Gly Phe Lys Thr Leu Glu Arg Ser Tyr Leu Leu Lys Ile Asn 
145                 150                 155                 160 


Gly Lys Val Ala Glu Arg Pro Gln His Met Leu Met Arg Val Ser Val 
                165                 170                 175     


Gly Ile His Lys Glu Asp Ile Asp Ala Ala Ile Glu Thr Tyr Asn Leu 
            180                 185                 190         


Leu Ser Glu Arg Trp Phe Thr His Ala Ser Pro Thr Leu Phe Asn Ala 
        195                 200                 205             


Gly Thr Asn Arg Pro Gln Leu Ser Ser Cys Phe Leu Leu Ser Met Lys 
    210                 215                 220                 


Asp Asp Ser Ile Glu Gly Ile Tyr Asp Thr Leu Lys Gln Cys Ala Leu 
225                 230                 235                 240 


Ile Ser Lys Ser Ala Gly Gly Ile Gly Val Ala Val Ser Cys Ile Arg 
                245                 250                 255     


Ala Thr Gly Ser Tyr Ile Ala Gly Thr Asn Gly Asn Ser Asn Gly Leu 
            260                 265                 270         


Val Pro Met Leu Arg Val Tyr Asn Asn Thr Ala Arg Tyr Val Asp Gln 
        275                 280                 285             


Gly Gly Asn Lys Arg Pro Gly Ala Phe Ala Ile Tyr Leu Glu Pro Trp 
    290                 295                 300                 


His Leu Asp Ile Phe Glu Phe Leu Asp Leu Lys Lys Asn Thr Gly Lys 
305                 310                 315                 320 


Glu Glu Gln Arg Ala Arg Asp Leu Phe Phe Ala Leu Trp Ile Pro Asp 
                325                 330                 335     


Leu Phe Met Lys Arg Val Glu Thr Asn Gln Asp Trp Ser Leu Met Cys 
            340                 345                 350         


Pro Asn Glu Cys Pro Gly Leu Asp Glu Val Trp Gly Glu Glu Phe Glu 
        355                 360                 365             


Lys Leu Tyr Ala Ser Tyr Glu Lys Gln Gly Arg Val Arg Lys Val Val 
    370                 375                 380                 


Lys Ala Gln Gln Leu Trp Tyr Ala Ile Ile Glu Ser Gln Thr Glu Thr 
385                 390                 395                 400 


Gly Thr Pro Tyr Met Leu Tyr Lys Asp Ser Cys Asn Arg Lys Ser Asn 
                405                 410                 415     


Gln Gln Asn Leu Gly Thr Ile Lys Cys Ser Asn Leu Cys Thr Glu Ile 
            420                 425                 430         


Val Glu Tyr Thr Ser Lys Asp Glu Val Ala Val Cys Asn Leu Ala Ser 
        435                 440                 445             


Leu Ala Leu Asn Met Tyr Val Thr Ser Glu His Thr Tyr Asp Phe Lys 
    450                 455                 460                 


Lys Leu Ala Glu Val Thr Lys Val Val Val Arg Asn Leu Asn Lys Ile 
465                 470                 475                 480 


Ile Asp Ile Asn Tyr Tyr Pro Val Pro Glu Ala Cys Leu Ser Asn Lys 
                485                 490                 495     


Arg His Arg Pro Ile Gly Ile Gly Val Gln Gly Leu Ala Asp Ala Phe 
            500                 505                 510         


Ile Leu Met Arg Tyr Pro Phe Glu Ser Ala Glu Ala Gln Leu Leu Asn 
        515                 520                 525             


Lys Gln Ile Phe Glu Thr Ile Tyr Tyr Gly Ala Leu Glu Ala Ser Cys 
    530                 535                 540                 


Asp Leu Ala Lys Glu Gln Gly Pro Tyr Glu Thr Tyr Glu Gly Ser Pro 
545                 550                 555                 560 


Val Ser Lys Gly Ile Leu Gln Tyr Asp Met Trp Asn Val Thr Pro Thr 
                565                 570                 575     


Asp Leu Trp Asp Trp Lys Val Leu Lys Glu Lys Ile Ala Lys Tyr Gly 
            580                 585                 590         


Ile Arg Asn Ser Leu Leu Ile Ala Pro Met Pro Thr Ala Ser Thr Ala 
        595                 600                 605             


Gln Ile Leu Gly Asn Asn Glu Ser Ile Glu Pro Tyr Thr Ser Asn Ile 
    610                 615                 620                 


Tyr Thr Arg Arg Val Leu Ser Gly Glu Phe Gln Ile Val Asn Pro His 
625                 630                 635                 640 


Leu Leu Lys Asp Leu Thr Glu Arg Gly Leu Trp His Glu Glu Met Lys 
                645                 650                 655     


Asn Gln Ile Ile Ala Cys Asn Gly Ser Ile Gln Ser Ile Pro Glu Ile 
            660                 665                 670         


Pro Asp Asp Leu Lys Gln Leu Tyr Lys Thr Val Trp Glu Ile Ser Gln 
        675                 680                 685             


Lys Thr Val Leu Lys Met Ala Ala Glu Arg Gly Ala Phe Ile Asp Gln 
    690                 695                 700                 


Ser Gln Ser Leu Asn Ile His Ile Ala Glu Pro Asn Tyr Gly Lys Leu 
705                 710                 715                 720 


Thr Ser Met His Phe Tyr Gly Trp Lys Gln Gly Leu Lys Thr Gly Met 
                725                 730                 735     


Tyr Tyr Leu Arg Thr Arg Pro Ala Ala Asn Pro Ile Gln Phe Thr Leu 
            740                 745                 750         


Asn Lys Glu Lys Leu Lys Asp Lys Glu Lys Val Ser Lys Glu Glu Glu 
        755                 760                 765             


Glu Lys Glu Arg Asn Thr Ala Ala Met Val Cys Ser Leu Glu Asn Arg 
    770                 775                 780                 


Asp Glu Cys Leu Met Cys Gly Ser 
785                 790         


<210>  146
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Ser Asp Thr Ser Glu Ser Gly Ala Gly Leu Thr Arg Phe Gln Ala 
1               5                   10                  15      


Glu Ala Ser Glu Lys Asp Ser Ser Ser Met Met Gln Thr Leu Leu Thr 
            20                  25                  30          


Val Thr Gln Asn Val Glu Val Pro Glu Thr Pro Lys Ala Ser Lys Ala 
        35                  40                  45              


Leu Glu Val Ser Glu Asp Val Lys Val Ser Lys Ala Ser Gly Val Ser 
    50                  55                  60                  


Lys Ala Thr Glu Val Ser Lys Thr Pro Glu Ala Arg Glu Ala Pro Ala 
65                  70                  75                  80  


Thr Gln Ala Ser Ser Thr Thr Gln Leu Thr Asp Thr Gln Val Leu Ala 
                85                  90                  95      


Ala Glu Asn Lys Ser Leu Ala Ala Asp Thr Lys Lys Gln Asn Ala Asp 
            100                 105                 110         


Pro Gln Ala Val Thr Met Pro Ala Thr Glu Thr Lys Lys Val Ser His 
        115                 120                 125             


Val Ala Asp Thr Lys Val Asn Thr Lys Ala Gln Glu Thr Glu Ala Ala 
    130                 135                 140                 


Pro Ser Gln Ala Pro Ala Asp Glu Pro Glu Pro Glu Ser Ala Ala Ala 
145                 150                 155                 160 


Gln Ser Gln Glu Asn Gln Asp Thr Arg Pro Lys Val Lys Ala Lys Lys 
                165                 170                 175     


Ala Arg Lys Val Lys His Leu Asp Gly Glu Glu Asp Gly Ser Ser Asp 
            180                 185                 190         


Gln Ser Gln Ala Ser Gly Thr Thr Gly Gly Arg Arg Val Ser Lys Ala 
        195                 200                 205             


Leu Met Ala Ser Met Ala Arg Arg Ala Ser Arg Gly Pro Ile Ala Phe 
    210                 215                 220                 


Trp Ala Arg Arg Ala Ser Arg Thr Arg Leu Ala Ala Trp Ala Arg Arg 
225                 230                 235                 240 


Ala Leu Leu Ser Leu Arg Ser Pro Lys Ala Arg Arg Gly Lys Ala Arg 
                245                 250                 255     


Arg Arg Ala Ala Lys Leu Gln Ser Ser Gln Glu Pro Glu Ala Pro Pro 
            260                 265                 270         


Pro Arg Asp Val Ala Leu Leu Gln Gly Arg Ala Asn Asp Leu Val Lys 
        275                 280                 285             


Tyr Leu Leu Ala Lys Asp Gln Thr Lys Ile Pro Ile Lys Arg Ser Asp 
    290                 295                 300                 


Met Leu Lys Asp Ile Ile Lys Glu Tyr Thr Asp Val Tyr Pro Glu Ile 
305                 310                 315                 320 


Ile Glu Arg Ala Gly Tyr Ser Leu Glu Lys Val Phe Gly Ile Gln Leu 
                325                 330                 335     


Lys Glu Ile Asp Lys Asn Asp His Leu Tyr Ile Leu Leu Ser Thr Leu 
            340                 345                 350         


Glu Pro Thr Asp Ala Gly Ile Leu Gly Thr Thr Lys Asp Ser Pro Lys 
        355                 360                 365             


Leu Gly Leu Leu Met Val Leu Leu Ser Ile Ile Phe Met Asn Gly Asn 
    370                 375                 380                 


Arg Ser Ser Glu Ala Val Ile Trp Glu Val Leu Arg Lys Leu Gly Leu 
385                 390                 395                 400 


Arg Pro Gly Ile His His Ser Leu Phe Gly Asp Val Lys Lys Leu Ile 
                405                 410                 415     


Thr Asp Glu Phe Val Lys Gln Lys Tyr Leu Asp Tyr Ala Arg Val Pro 
            420                 425                 430         


Asn Ser Asn Pro Pro Glu Tyr Glu Phe Phe Trp Gly Leu Arg Ser Tyr 
        435                 440                 445             


Tyr Glu Thr Ser Lys Met Lys Val Leu Lys Phe Ala Cys Lys Val Gln 
    450                 455                 460                 


Lys Lys Asp Pro Lys Glu Trp Ala Ala Gln Tyr Arg Glu Ala Met Glu 
465                 470                 475                 480 


Ala Asp Leu Lys Ala Ala Ala Glu Ala Ala Ala Glu Ala Lys Ala Arg 
                485                 490                 495     


Ala Glu Ile Arg Ala Arg Met Gly Ile Gly Leu Gly Ser Glu Asn Ala 
            500                 505                 510         


Ala Gly Pro Cys Asn Trp Asp Glu Ala Asp Ile Gly Pro Trp Ala Lys 
        515                 520                 525             


Ala Arg Ile Gln Ala Gly Ala Glu Ala Lys Ala Lys Ala Gln Glu Ser 
    530                 535                 540                 


Gly Ser Ala Ser Thr Gly Ala Ser Thr Ser Thr Asn Asn Ser Ala Ser 
545                 550                 555                 560 


Ala Ser Ala Ser Thr Ser Gly Gly Phe Ser Ala Gly Ala Ser Leu Thr 
                565                 570                 575     


Ala Thr Leu Thr Phe Gly Leu Phe Ala Gly Leu Gly Gly Ala Gly Ala 
            580                 585                 590         


Ser Thr Ser Gly Ser Ser Gly Ala Cys Gly Phe Ser Tyr Lys 
        595                 600                 605     


<210>  147
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  147

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  148
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Leu Leu Arg Ser Lys Pro Ala Leu Pro Pro Pro Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Leu Gly Pro Leu Ser Pro Gly Ala Leu Pro Arg Pro 
            20                  25                  30          


Ala Gln Ala Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro 
        35                  40                  45              


Leu His Leu Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn 
    50                  55                  60                  


Leu Ala Thr Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu 
65                  70                  75                  80  


Arg Thr Leu Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly 
                85                  90                  95      


Thr Lys Thr Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr Phe 
            100                 105                 110         


Glu Glu Arg Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys Lys 
        115                 120                 125             


Tyr Gly Ser Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu Trp 
    130                 135                 140                 


Pro Tyr Gln Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys Phe 
145                 150                 155                 160 


Lys Asn Ser Thr Tyr Ser Arg Ser Ser Val Asp Val Leu Tyr Thr Phe 
                165                 170                 175     


Ala Asn Cys Ser Gly Leu Asp Leu Ile Phe Gly Leu Asn Ala Leu Leu 
            180                 185                 190         


Arg Thr Ala Asp Leu Gln Trp Asn Ser Ser Asn Ala Gln Leu Leu Leu 
        195                 200                 205             


Asp Tyr Cys Ser Ser Lys Gly Tyr Asn Ile Ser Trp Glu Leu Gly Asn 
    210                 215                 220                 


Glu Pro Asn Ser Phe Leu Lys Lys Ala Asp Ile Phe Ile Asn Gly Ser 
225                 230                 235                 240 


Gln Leu Gly Glu Asp Phe Ile Gln Leu His Lys Leu Leu Arg Lys Ser 
                245                 250                 255     


Thr Phe Lys Asn Ala Lys Leu Tyr Gly Pro Asp Val Gly Gln Pro Arg 
            260                 265                 270         


Arg Lys Thr Ala Lys Met Leu Lys Ser Phe Leu Lys Ala Gly Gly Glu 
        275                 280                 285             


Val Ile Asp Ser Val Thr Trp His His Tyr Tyr Leu Asn Gly Arg Thr 
    290                 295                 300                 


Ala Thr Lys Glu Asp Phe Leu Asn Pro Asp Val Leu Asp Ile Phe Ile 
305                 310                 315                 320 


Ser Ser Val Gln Lys Val Phe Gln Val Val Glu Ser Thr Arg Pro Gly 
                325                 330                 335     


Lys Lys Val Trp Leu Gly Glu Thr Ser Ser Ala Tyr Gly Gly Gly Ala 
            340                 345                 350         


Pro Leu Leu Ser Asp Thr Phe Ala Ala Gly Phe Met Trp Leu Asp Lys 
        355                 360                 365             


Leu Gly Leu Ser Ala Arg Met Gly Ile Glu Val Val Met Arg Gln Val 
    370                 375                 380                 


Phe Phe Gly Ala Gly Asn Tyr His Leu Val Asp Glu Asn Phe Asp Pro 
385                 390                 395                 400 


Leu Pro Asp Tyr Trp Leu Ser Leu Leu Phe Lys Lys Leu Val Gly Thr 
                405                 410                 415     


Lys Val Leu Met Ala Ser Val Gln Gly Ser Lys Arg Arg Lys Leu Arg 
            420                 425                 430         


Val Tyr Leu His Cys Thr Asn Thr Asp Asn Pro Arg Tyr Lys Glu Gly 
        435                 440                 445             


Asp Leu Thr Leu Tyr Ala Ile Asn Leu His Asn Val Thr Lys Tyr Leu 
    450                 455                 460                 


Arg Leu Pro Tyr Pro Phe Ser Asn Lys Gln Val Asp Lys Tyr Leu Leu 
465                 470                 475                 480 


Arg Pro Leu Gly Pro His Gly Leu Leu Ser Lys Ser Val Gln Leu Asn 
                485                 490                 495     


Gly Leu Thr Leu Lys Met Val Asp Asp Gln Thr Leu Pro Pro Leu Met 
            500                 505                 510         


Glu Lys Pro Leu Arg Pro Gly Ser Ser Leu Gly Leu Pro Ala Phe Ser 
        515                 520                 525             


Tyr Ser Phe Phe Val Ile Arg Asn Ala Lys Val Ala Ala Cys Ile 
    530                 535                 540             


<210>  149
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  149

Met Ser Thr Asn Glu Asn Ala Asn Thr Pro Ala Ala Arg Leu His Arg 
1               5                   10                  15      


Phe Lys Asn Lys Gly Lys Asp Ser Thr Glu Met Arg Arg Arg Arg Ile 
            20                  25                  30          


Glu Val Asn Val Glu Leu Arg Lys Ala Lys Lys Asp Asp Gln Met Leu 
        35                  40                  45              


Lys Arg Arg Asn Val Ser Ser Phe Pro Asp Asp Ala Thr Ser Pro Leu 
    50                  55                  60                  


Gln Glu Asn Arg Asn Asn Gln Gly Thr Val Asn Trp Ser Val Asp Asp 
65                  70                  75                  80  


Ile Val Lys Gly Ile Asn Ser Ser Asn Val Glu Asn Gln Leu Gln Ala 
                85                  90                  95      


Thr Gln Ala Ala Arg Lys Leu Leu Ser Arg Glu Lys Gln Pro Pro Ile 
            100                 105                 110         


Asp Asn Ile Ile Arg Ala Gly Leu Ile Pro Lys Phe Val Ser Phe Leu 
        115                 120                 125             


Gly Arg Thr Asp Cys Ser Pro Ile Gln Phe Glu Ser Ala Trp Ala Leu 
    130                 135                 140                 


Thr Asn Ile Ala Ser Gly Thr Ser Glu Gln Thr Lys Ala Val Val Asp 
145                 150                 155                 160 


Gly Gly Ala Ile Pro Ala Phe Ile Ser Leu Leu Ala Ser Pro His Ala 
                165                 170                 175     


His Ile Ser Glu Gln Ala Val Trp Ala Leu Gly Asn Ile Ala Gly Asp 
            180                 185                 190         


Gly Ser Val Phe Arg Asp Leu Val Ile Lys Tyr Gly Ala Val Asp Pro 
        195                 200                 205             


Leu Leu Ala Leu Leu Ala Val Pro Asp Met Ser Ser Leu Ala Cys Gly 
    210                 215                 220                 


Tyr Leu Arg Asn Leu Thr Trp Thr Leu Ser Asn Leu Cys Arg Asn Lys 
225                 230                 235                 240 


Asn Pro Ala Pro Pro Ile Asp Ala Val Glu Gln Ile Leu Pro Thr Leu 
                245                 250                 255     


Val Arg Leu Leu His His Asp Asp Pro Glu Val Leu Ala Asp Thr Cys 
            260                 265                 270         


Trp Ala Ile Ser Tyr Leu Thr Asp Gly Pro Asn Glu Arg Ile Gly Met 
        275                 280                 285             


Val Val Lys Thr Gly Val Val Pro Gln Leu Val Lys Leu Leu Gly Ala 
    290                 295                 300                 


Ser Glu Leu Pro Ile Val Thr Pro Ala Leu Arg Ala Ile Gly Asn Ile 
305                 310                 315                 320 


Val Thr Gly Thr Asp Glu Gln Thr Gln Val Val Ile Asp Ala Gly Ala 
                325                 330                 335     


Leu Ala Val Phe Pro Ser Leu Leu Thr Asn Pro Lys Thr Asn Ile Gln 
            340                 345                 350         


Lys Glu Ala Thr Trp Thr Met Ser Asn Ile Thr Ala Gly Arg Gln Asp 
        355                 360                 365             


Gln Ile Gln Gln Val Val Asn His Gly Leu Val Pro Phe Leu Val Ser 
    370                 375                 380                 


Val Leu Ser Lys Ala Asp Phe Lys Thr Gln Lys Glu Ala Val Trp Ala 
385                 390                 395                 400 


Val Thr Asn Tyr Thr Ser Gly Gly Thr Val Glu Gln Ile Val Tyr Leu 
                405                 410                 415     


Val His Cys Gly Ile Ile Glu Pro Leu Met Asn Leu Leu Thr Ala Lys 
            420                 425                 430         


Asp Thr Lys Ile Ile Leu Val Ile Leu Asp Ala Ile Ser Asn Ile Phe 
        435                 440                 445             


Gln Ala Ala Glu Lys Leu Gly Glu Thr Glu Lys Leu Ser Ile Met Ile 
    450                 455                 460                 


Glu Glu Cys Gly Gly Leu Asp Lys Ile Glu Ala Leu Gln Asn His Glu 
465                 470                 475                 480 


Asn Glu Ser Val Tyr Lys Ala Ser Leu Ser Leu Ile Glu Lys Tyr Phe 
                485                 490                 495     


Ser Val Glu Glu Glu Glu Asp Gln Asn Val Val Pro Glu Thr Thr Ser 
            500                 505                 510         


Glu Gly Tyr Thr Phe Gln Val Gln Asp Gly Ala Pro Gly Thr Phe Asn 
        515                 520                 525             


Phe 
    


<210>  150
<211>  561
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Cys Gly Ile Trp Ala Leu Phe Gly Ser Asp Asp Cys Leu Ser Val 
1               5                   10                  15      


Gln Cys Leu Ser Ala Met Lys Ile Ala His Arg Gly Pro Asp Ala Phe 
            20                  25                  30          


Arg Phe Glu Asn Val Asn Gly Tyr Thr Asn Cys Cys Phe Gly Phe His 
        35                  40                  45              


Arg Leu Ala Val Val Asp Pro Leu Phe Gly Met Gln Pro Ile Arg Val 
    50                  55                  60                  


Lys Lys Tyr Pro Tyr Leu Trp Leu Cys Tyr Asn Gly Glu Ile Tyr Asn 
65                  70                  75                  80  


His Lys Lys Met Gln Gln His Phe Glu Phe Glu Tyr Gln Thr Lys Val 
                85                  90                  95      


Asp Gly Glu Ile Ile Leu His Leu Tyr Asp Lys Gly Gly Ile Glu Gln 
            100                 105                 110         


Thr Ile Cys Met Leu Asp Gly Val Phe Ala Phe Val Leu Leu Asp Thr 
        115                 120                 125             


Ala Asn Lys Lys Val Phe Leu Gly Arg Asp Thr Tyr Gly Val Arg Pro 
    130                 135                 140                 


Leu Phe Lys Ala Met Thr Glu Asp Gly Phe Leu Ala Val Cys Ser Glu 
145                 150                 155                 160 


Ala Lys Gly Leu Val Thr Leu Lys His Ser Ala Thr Pro Phe Leu Lys 
                165                 170                 175     


Val Glu Pro Phe Leu Pro Gly His Tyr Glu Val Leu Asp Leu Lys Pro 
            180                 185                 190         


Asn Gly Lys Val Ala Ser Val Glu Met Val Lys Tyr His His Cys Arg 
        195                 200                 205             


Asp Val Pro Leu His Ala Leu Tyr Asp Asn Val Glu Lys Leu Phe Pro 
    210                 215                 220                 


Gly Phe Glu Ile Glu Thr Val Lys Asn Asn Leu Arg Ile Leu Phe Asn 
225                 230                 235                 240 


Asn Ala Val Lys Lys Arg Leu Met Thr Asp Arg Arg Ile Gly Cys Leu 
                245                 250                 255     


Leu Ser Gly Gly Leu Asp Ser Ser Leu Val Ala Ala Thr Leu Leu Lys 
            260                 265                 270         


Gln Leu Lys Glu Ala Gln Val Gln Tyr Pro Leu Gln Thr Phe Ala Ile 
        275                 280                 285             


Gly Met Glu Asp Ser Pro Asp Leu Leu Ala Ala Arg Lys Val Ala Asp 
    290                 295                 300                 


His Ile Gly Ser Glu His Tyr Glu Val Leu Phe Asn Ser Glu Glu Gly 
305                 310                 315                 320 


Ile Gln Ala Leu Asp Glu Val Ile Phe Ser Leu Glu Thr Tyr Asp Ile 
                325                 330                 335     


Thr Thr Val Arg Ala Ser Val Gly Met Tyr Leu Ile Ser Lys Tyr Ile 
            340                 345                 350         


Arg Lys Asn Thr Asp Ser Val Val Ile Phe Ser Gly Glu Gly Ser Asp 
        355                 360                 365             


Glu Leu Thr Gln Gly Tyr Ile Tyr Phe His Lys Ala Pro Ser Pro Glu 
    370                 375                 380                 


Lys Ala Glu Glu Glu Ser Glu Arg Leu Leu Arg Glu Leu Tyr Leu Phe 
385                 390                 395                 400 


Asp Val Leu Arg Ala Asp Arg Thr Thr Ala Ala His Gly Leu Glu Leu 
                405                 410                 415     


Arg Val Pro Phe Leu Asp His Arg Phe Ser Ser Tyr Tyr Leu Ser Leu 
            420                 425                 430         


Pro Pro Glu Met Arg Ile Pro Lys Asn Gly Ile Glu Lys His Leu Leu 
        435                 440                 445             


Arg Glu Thr Phe Glu Asp Ser Asn Leu Ile Pro Lys Glu Ile Leu Trp 
    450                 455                 460                 


Arg Pro Lys Glu Ala Phe Ser Asp Gly Ile Thr Ser Val Lys Asn Ser 
465                 470                 475                 480 


Trp Phe Lys Ile Leu Gln Glu Tyr Val Glu His Gln Val Asp Asp Ala 
                485                 490                 495     


Met Met Ala Asn Ala Ala Gln Lys Phe Pro Phe Asn Thr Pro Lys Thr 
            500                 505                 510         


Lys Glu Gly Tyr Tyr Tyr Arg Gln Val Phe Glu Arg His Tyr Pro Gly 
        515                 520                 525             


Arg Ala Asp Trp Leu Ser His Tyr Trp Met Pro Lys Trp Ile Asn Ala 
    530                 535                 540                 


Thr Asp Pro Ser Ala Arg Thr Leu Thr His Tyr Lys Ser Ala Val Lys 
545                 550                 555                 560 


Ala 
    


<210>  151
<211>  1474
<212>  PRT
<213>  Homo sapiens

<400>  151

Met Gly Lys Asn Lys Leu Leu His Pro Ser Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Leu Pro Thr Asp Ala Ser Val Ser Gly Lys Pro Gln Tyr Met 
            20                  25                  30          


Val Leu Val Pro Ser Leu Leu His Thr Glu Thr Thr Glu Lys Gly Cys 
        35                  40                  45              


Val Leu Leu Ser Tyr Leu Asn Glu Thr Val Thr Val Ser Ala Ser Leu 
    50                  55                  60                  


Glu Ser Val Arg Gly Asn Arg Ser Leu Phe Thr Asp Leu Glu Ala Glu 
65                  70                  75                  80  


Asn Asp Val Leu His Cys Val Ala Phe Ala Val Pro Lys Ser Ser Ser 
                85                  90                  95      


Asn Glu Glu Val Met Phe Leu Thr Val Gln Val Lys Gly Pro Thr Gln 
            100                 105                 110         


Glu Phe Lys Lys Arg Thr Thr Val Met Val Lys Asn Glu Asp Ser Leu 
        115                 120                 125             


Val Phe Val Gln Thr Asp Lys Ser Ile Tyr Lys Pro Gly Gln Thr Val 
    130                 135                 140                 


Lys Phe Arg Val Val Ser Met Asp Glu Asn Phe His Pro Leu Asn Glu 
145                 150                 155                 160 


Leu Ile Pro Leu Val Tyr Ile Gln Asp Pro Lys Gly Asn Arg Ile Ala 
                165                 170                 175     


Gln Trp Gln Ser Phe Gln Leu Glu Gly Gly Leu Lys Gln Phe Ser Phe 
            180                 185                 190         


Pro Leu Ser Ser Glu Pro Phe Gln Gly Ser Tyr Lys Val Val Val Gln 
        195                 200                 205             


Lys Lys Ser Gly Gly Arg Thr Glu His Pro Phe Thr Val Glu Glu Phe 
    210                 215                 220                 


Val Leu Pro Lys Phe Glu Val Gln Val Thr Val Pro Lys Ile Ile Thr 
225                 230                 235                 240 


Ile Leu Glu Glu Glu Met Asn Val Ser Val Cys Gly Leu Tyr Thr Tyr 
                245                 250                 255     


Gly Lys Pro Val Pro Gly His Val Thr Val Ser Ile Cys Arg Lys Tyr 
            260                 265                 270         


Ser Asp Ala Ser Asp Cys His Gly Glu Asp Ser Gln Ala Phe Cys Glu 
        275                 280                 285             


Lys Phe Ser Gly Gln Leu Asn Ser His Gly Cys Phe Tyr Gln Gln Val 
    290                 295                 300                 


Lys Thr Lys Val Phe Gln Leu Lys Arg Lys Glu Tyr Glu Met Lys Leu 
305                 310                 315                 320 


His Thr Glu Ala Gln Ile Gln Glu Glu Gly Thr Val Val Glu Leu Thr 
                325                 330                 335     


Gly Arg Gln Ser Ser Glu Ile Thr Arg Thr Ile Thr Lys Leu Ser Phe 
            340                 345                 350         


Val Lys Val Asp Ser His Phe Arg Gln Gly Ile Pro Phe Phe Gly Gln 
        355                 360                 365             


Val Arg Leu Val Asp Gly Lys Gly Val Pro Ile Pro Asn Lys Val Ile 
    370                 375                 380                 


Phe Ile Arg Gly Asn Glu Ala Asn Tyr Tyr Ser Asn Ala Thr Thr Asp 
385                 390                 395                 400 


Glu His Gly Leu Val Gln Phe Ser Ile Asn Thr Thr Asn Val Met Gly 
                405                 410                 415     


Thr Ser Leu Thr Val Arg Val Asn Tyr Lys Asp Arg Ser Pro Cys Tyr 
            420                 425                 430         


Gly Tyr Gln Trp Val Ser Glu Glu His Glu Glu Ala His His Thr Ala 
        435                 440                 445             


Tyr Leu Val Phe Ser Pro Ser Lys Ser Phe Val His Leu Glu Pro Met 
    450                 455                 460                 


Ser His Glu Leu Pro Cys Gly His Thr Gln Thr Val Gln Ala His Tyr 
465                 470                 475                 480 


Ile Leu Asn Gly Gly Thr Leu Leu Gly Leu Lys Lys Leu Ser Phe Tyr 
                485                 490                 495     


Tyr Leu Ile Met Ala Lys Gly Gly Ile Val Arg Thr Gly Thr His Gly 
            500                 505                 510         


Leu Leu Val Lys Gln Glu Asp Met Lys Gly His Phe Ser Ile Ser Ile 
        515                 520                 525             


Pro Val Lys Ser Asp Ile Ala Pro Val Ala Arg Leu Leu Ile Tyr Ala 
    530                 535                 540                 


Val Leu Pro Thr Gly Asp Val Ile Gly Asp Ser Ala Lys Tyr Asp Val 
545                 550                 555                 560 


Glu Asn Cys Leu Ala Asn Lys Val Asp Leu Ser Phe Ser Pro Ser Gln 
                565                 570                 575     


Ser Leu Pro Ala Ser His Ala His Leu Arg Val Thr Ala Ala Pro Gln 
            580                 585                 590         


Ser Val Cys Ala Leu Arg Ala Val Asp Gln Ser Val Leu Leu Met Lys 
        595                 600                 605             


Pro Asp Ala Glu Leu Ser Ala Ser Ser Val Tyr Asn Leu Leu Pro Glu 
    610                 615                 620                 


Lys Asp Leu Thr Gly Phe Pro Gly Pro Leu Asn Asp Gln Asp Asn Glu 
625                 630                 635                 640 


Asp Cys Ile Asn Arg His Asn Val Tyr Ile Asn Gly Ile Thr Tyr Thr 
                645                 650                 655     


Pro Val Ser Ser Thr Asn Glu Lys Asp Met Tyr Ser Phe Leu Glu Asp 
            660                 665                 670         


Met Gly Leu Lys Ala Phe Thr Asn Ser Lys Ile Arg Lys Pro Lys Met 
        675                 680                 685             


Cys Pro Gln Leu Gln Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg 
    690                 695                 700                 


Val Gly Phe Tyr Glu Ser Asp Val Met Gly Arg Gly His Ala Arg Leu 
705                 710                 715                 720 


Val His Val Glu Glu Pro His Thr Glu Thr Val Arg Lys Tyr Phe Pro 
                725                 730                 735     


Glu Thr Trp Ile Trp Asp Leu Val Val Val Asn Ser Ala Gly Val Ala 
            740                 745                 750         


Glu Val Gly Val Thr Val Pro Asp Thr Ile Thr Glu Trp Lys Ala Gly 
        755                 760                 765             


Ala Phe Cys Leu Ser Glu Asp Ala Gly Leu Gly Ile Ser Ser Thr Ala 
    770                 775                 780                 


Ser Leu Arg Ala Phe Gln Pro Phe Phe Val Glu Leu Thr Met Pro Tyr 
785                 790                 795                 800 


Ser Val Ile Arg Gly Glu Ala Phe Thr Leu Lys Ala Thr Val Leu Asn 
                805                 810                 815     


Tyr Leu Pro Lys Cys Ile Arg Val Ser Val Gln Leu Glu Ala Ser Pro 
            820                 825                 830         


Ala Phe Leu Ala Val Pro Val Glu Lys Glu Gln Ala Pro His Cys Ile 
        835                 840                 845             


Cys Ala Asn Gly Arg Gln Thr Val Ser Trp Ala Val Thr Pro Lys Ser 
    850                 855                 860                 


Leu Gly Asn Val Asn Phe Thr Val Ser Ala Glu Ala Leu Glu Ser Gln 
865                 870                 875                 880 


Glu Leu Cys Gly Thr Glu Val Pro Ser Val Pro Glu His Gly Arg Lys 
                885                 890                 895     


Asp Thr Val Ile Lys Pro Leu Leu Val Glu Pro Glu Gly Leu Glu Lys 
            900                 905                 910         


Glu Thr Thr Phe Asn Ser Leu Leu Cys Pro Ser Gly Gly Glu Val Ser 
        915                 920                 925             


Glu Glu Leu Ser Leu Lys Leu Pro Pro Asn Val Val Glu Glu Ser Ala 
    930                 935                 940                 


Arg Ala Ser Val Ser Val Leu Gly Asp Ile Leu Gly Ser Ala Met Gln 
945                 950                 955                 960 


Asn Thr Gln Asn Leu Leu Gln Met Pro Tyr Gly Cys Gly Glu Gln Asn 
                965                 970                 975     


Met Val Leu Phe Ala Pro Asn Ile Tyr Val Leu Asp Tyr Leu Asn Glu 
            980                 985                 990         


Thr Gln Gln Leu Thr Pro Glu Ile  Lys Ser Lys Ala Ile  Gly Tyr Leu 
        995                 1000                 1005             


Asn Thr  Gly Tyr Gln Arg Gln  Leu Asn Tyr Lys His  Tyr Asp Gly 
    1010                 1015                 1020             


Ser Tyr  Ser Thr Phe Gly Glu  Arg Tyr Gly Arg Asn  Gln Gly Asn 
    1025                 1030                 1035             


Thr Trp  Leu Thr Ala Phe Val  Leu Lys Thr Phe Ala  Gln Ala Arg 
    1040                 1045                 1050             


Ala Tyr  Ile Phe Ile Asp Glu  Ala His Ile Thr Gln  Ala Leu Ile 
    1055                 1060                 1065             


Trp Leu  Ser Gln Arg Gln Lys  Asp Asn Gly Cys Phe  Arg Ser Ser 
    1070                 1075                 1080             


Gly Ser  Leu Leu Asn Asn Ala  Ile Lys Gly Gly Val  Glu Asp Glu 
    1085                 1090                 1095             


Val Thr  Leu Ser Ala Tyr Ile  Thr Ile Ala Leu Leu  Glu Ile Pro 
    1100                 1105                 1110             


Leu Thr  Val Thr His Pro Val  Val Arg Asn Ala Leu  Phe Cys Leu 
    1115                 1120                 1125             


Glu Ser  Ala Trp Lys Thr Ala  Gln Glu Gly Asp His  Gly Ser His 
    1130                 1135                 1140             


Val Tyr  Thr Lys Ala Leu Leu  Ala Tyr Ala Phe Ala  Leu Ala Gly 
    1145                 1150                 1155             


Asn Gln  Asp Lys Arg Lys Glu  Val Leu Lys Ser Leu  Asn Glu Glu 
    1160                 1165                 1170             


Ala Val  Lys Lys Asp Asn Ser  Val His Trp Glu Arg  Pro Gln Lys 
    1175                 1180                 1185             


Pro Lys  Ala Pro Val Gly His  Phe Tyr Glu Pro Gln  Ala Pro Ser 
    1190                 1195                 1200             


Ala Glu  Val Glu Met Thr Ser  Tyr Val Leu Leu Ala  Tyr Leu Thr 
    1205                 1210                 1215             


Ala Gln  Pro Ala Pro Thr Ser  Glu Asp Leu Thr Ser  Ala Thr Asn 
    1220                 1225                 1230             


Ile Val  Lys Trp Ile Thr Lys  Gln Gln Asn Ala Gln  Gly Gly Phe 
    1235                 1240                 1245             


Ser Ser  Thr Gln Asp Thr Val  Val Ala Leu His Ala  Leu Ser Lys 
    1250                 1255                 1260             


Tyr Gly  Ala Ala Thr Phe Thr  Arg Thr Gly Lys Ala  Ala Gln Val 
    1265                 1270                 1275             


Thr Ile  Gln Ser Ser Gly Thr  Phe Ser Ser Lys Phe  Gln Val Asp 
    1280                 1285                 1290             


Asn Asn  Asn Arg Leu Leu Leu  Gln Gln Val Ser Leu  Pro Glu Leu 
    1295                 1300                 1305             


Pro Gly  Glu Tyr Ser Met Lys  Val Thr Gly Glu Gly  Cys Val Tyr 
    1310                 1315                 1320             


Leu Gln  Thr Ser Leu Lys Tyr  Asn Ile Leu Pro Glu  Lys Glu Glu 
    1325                 1330                 1335             


Phe Pro  Phe Ala Leu Gly Val  Gln Thr Leu Pro Gln  Thr Cys Asp 
    1340                 1345                 1350             


Glu Pro  Lys Ala His Thr Ser  Phe Gln Ile Ser Leu  Ser Val Ser 
    1355                 1360                 1365             


Tyr Thr  Gly Ser Arg Ser Ala  Ser Asn Met Ala Ile  Val Asp Val 
    1370                 1375                 1380             


Lys Met  Val Ser Gly Phe Ile  Pro Leu Lys Pro Thr  Val Lys Met 
    1385                 1390                 1395             


Leu Glu  Arg Ser Asn His Val  Ser Arg Thr Glu Val  Ser Ser Asn 
    1400                 1405                 1410             


His Val  Leu Ile Tyr Leu Asp  Lys Val Ser Asn Gln  Thr Leu Ser 
    1415                 1420                 1425             


Leu Phe  Phe Thr Val Leu Gln  Asp Val Pro Val Arg  Asp Leu Lys 
    1430                 1435                 1440             


Pro Ala  Ile Val Lys Val Tyr  Asp Tyr Tyr Glu Thr  Asp Glu Phe 
    1445                 1450                 1455             


Ala Ile  Ala Glu Tyr Asn Ala  Pro Cys Ser Lys Asp  Leu Gly Asn 
    1460                 1465                 1470             


Ala 
    


<210>  152
<211>  1464
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr 
1               5                   10                  15      


Ala Leu Leu Thr His Gly Gln Glu Glu Gly Gln Val Glu Gly Gln Asp 
            20                  25                  30          


Glu Asp Ile Pro Pro Ile Thr Cys Val Gln Asn Gly Leu Arg Tyr His 
        35                  40                  45              


Asp Arg Asp Val Trp Lys Pro Glu Pro Cys Arg Ile Cys Val Cys Asp 
    50                  55                  60                  


Asn Gly Lys Val Leu Cys Asp Asp Val Ile Cys Asp Glu Thr Lys Asn 
65                  70                  75                  80  


Cys Pro Gly Ala Glu Val Pro Glu Gly Glu Cys Cys Pro Val Cys Pro 
                85                  90                  95      


Asp Gly Ser Glu Ser Pro Thr Asp Gln Glu Thr Thr Gly Val Glu Gly 
            100                 105                 110         


Pro Lys Gly Asp Thr Gly Pro Arg Gly Pro Arg Gly Pro Ala Gly Pro 
        115                 120                 125             


Pro Gly Arg Asp Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Pro Pro 
    130                 135                 140                 


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala 
145                 150                 155                 160 


Pro Gln Leu Ser Tyr Gly Tyr Asp Glu Lys Ser Thr Gly Gly Ile Ser 
                165                 170                 175     


Val Pro Gly Pro Met Gly Pro Ser Gly Pro Arg Gly Leu Pro Gly Pro 
            180                 185                 190         


Pro Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Pro Gly Glu Pro 
        195                 200                 205             


Gly Glu Pro Gly Ala Ser Gly Pro Met Gly Pro Arg Gly Pro Pro Gly 
    210                 215                 220                 


Pro Pro Gly Lys Asn Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Arg 
225                 230                 235                 240 


Pro Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly Leu Pro 
                245                 250                 255     


Gly Thr Ala Gly Leu Pro Gly Met Lys Gly His Arg Gly Phe Ser Gly 
            260                 265                 270         


Leu Asp Gly Ala Lys Gly Asp Ala Gly Pro Ala Gly Pro Lys Gly Glu 
        275                 280                 285             


Pro Gly Ser Pro Gly Glu Asn Gly Ala Pro Gly Gln Met Gly Pro Arg 
    290                 295                 300                 


Gly Leu Pro Gly Glu Arg Gly Arg Pro Gly Ala Pro Gly Pro Ala Gly 
305                 310                 315                 320 


Ala Arg Gly Asn Asp Gly Ala Thr Gly Ala Ala Gly Pro Pro Gly Pro 
                325                 330                 335     


Thr Gly Pro Ala Gly Pro Pro Gly Phe Pro Gly Ala Val Gly Ala Lys 
            340                 345                 350         


Gly Glu Ala Gly Pro Gln Gly Pro Arg Gly Ser Glu Gly Pro Gln Gly 
        355                 360                 365             


Val Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Ala Gly Pro 
    370                 375                 380                 


Ala Gly Asn Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Ala Asn 
385                 390                 395                 400 


Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Ala Arg Gly 
                405                 410                 415     


Pro Ser Gly Pro Gln Gly Pro Gly Gly Pro Pro Gly Pro Lys Gly Asn 
            420                 425                 430         


Ser Gly Glu Pro Gly Ala Pro Gly Ser Lys Gly Asp Thr Gly Ala Lys 
        435                 440                 445             


Gly Glu Pro Gly Pro Val Gly Val Gln Gly Pro Pro Gly Pro Ala Gly 
    450                 455                 460                 


Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Pro Thr Gly Leu 
465                 470                 475                 480 


Pro Gly Pro Pro Gly Glu Arg Gly Gly Pro Gly Ser Arg Gly Phe Pro 
                485                 490                 495     


Gly Ala Asp Gly Val Ala Gly Pro Lys Gly Pro Ala Gly Glu Arg Gly 
            500                 505                 510         


Ser Pro Gly Pro Ala Gly Pro Lys Gly Ser Pro Gly Glu Ala Gly Arg 
        515                 520                 525             


Pro Gly Glu Ala Gly Leu Pro Gly Ala Lys Gly Leu Thr Gly Ser Pro 
    530                 535                 540                 


Gly Ser Pro Gly Pro Asp Gly Lys Thr Gly Pro Pro Gly Pro Ala Gly 
545                 550                 555                 560 


Gln Asp Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Ala Arg Gly Gln 
                565                 570                 575     


Ala Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Ala Gly Glu Pro 
            580                 585                 590         


Gly Lys Ala Gly Glu Arg Gly Val Pro Gly Pro Pro Gly Ala Val Gly 
        595                 600                 605             


Pro Ala Gly Lys Asp Gly Glu Ala Gly Ala Gln Gly Pro Pro Gly Pro 
    610                 615                 620                 


Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Pro Ala Gly Ser Pro 
625                 630                 635                 640 


Gly Phe Gln Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Glu Ala Gly 
                645                 650                 655     


Lys Pro Gly Glu Gln Gly Val Pro Gly Asp Leu Gly Ala Pro Gly Pro 
            660                 665                 670         


Ser Gly Ala Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly Val Gln 
        675                 680                 685             


Gly Pro Pro Gly Pro Ala Gly Pro Arg Gly Ala Asn Gly Ala Pro Gly 
    690                 695                 700                 


Asn Asp Gly Ala Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Ser 
705                 710                 715                 720 


Gln Gly Ala Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ala Ala 
                725                 730                 735     


Gly Leu Pro Gly Pro Lys Gly Asp Arg Gly Asp Ala Gly Pro Lys Gly 
            740                 745                 750         


Ala Asp Gly Ser Pro Gly Lys Asp Gly Val Arg Gly Leu Thr Gly Pro 
        755                 760                 765             


Ile Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Asp Lys Gly Glu Ser 
    770                 775                 780                 


Gly Pro Ser Gly Pro Ala Gly Pro Thr Gly Ala Arg Gly Ala Pro Gly 
785                 790                 795                 800 


Asp Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Phe Ala Gly Pro 
                805                 810                 815     


Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Pro Gly Asp Ala 
            820                 825                 830         


Gly Ala Lys Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly 
        835                 840                 845             


Pro Pro Gly Pro Ile Gly Asn Val Gly Ala Pro Gly Ala Lys Gly Ala 
    850                 855                 860                 


Arg Gly Ser Ala Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ala Ala 
865                 870                 875                 880 


Gly Arg Val Gly Pro Pro Gly Pro Ser Gly Asn Ala Gly Pro Pro Gly 
                885                 890                 895     


Pro Pro Gly Pro Ala Gly Lys Glu Gly Gly Lys Gly Pro Arg Gly Glu 
            900                 905                 910         


Thr Gly Pro Ala Gly Arg Pro Gly Glu Val Gly Pro Pro Gly Pro Pro 
        915                 920                 925             


Gly Pro Ala Gly Glu Lys Gly Ser Pro Gly Ala Asp Gly Pro Ala Gly 
    930                 935                 940                 


Ala Pro Gly Thr Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg Gly Val 
945                 950                 955                 960 


Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly Leu Pro 
                965                 970                 975     


Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Pro Ser Gly Ala Ser Gly 
            980                 985                 990         


Glu Arg Gly Pro Pro Gly Pro Met  Gly Pro Pro Gly Leu  Ala Gly Pro 
        995                 1000                 1005             


Pro Gly  Glu Ser Gly Arg Glu  Gly Ala Pro Gly Ala  Glu Gly Ser 
    1010                 1015                 1020             


Pro Gly  Arg Asp Gly Ser Pro  Gly Ala Lys Gly Asp  Arg Gly Glu 
    1025                 1030                 1035             


Thr Gly  Pro Ala Gly Pro Pro  Gly Ala Pro Gly Ala  Pro Gly Ala 
    1040                 1045                 1050             


Pro Gly  Pro Val Gly Pro Ala  Gly Lys Ser Gly Asp  Arg Gly Glu 
    1055                 1060                 1065             


Thr Gly  Pro Ala Gly Pro Thr  Gly Pro Val Gly Pro  Val Gly Ala 
    1070                 1075                 1080             


Arg Gly  Pro Ala Gly Pro Gln  Gly Pro Arg Gly Asp  Lys Gly Glu 
    1085                 1090                 1095             


Thr Gly  Glu Gln Gly Asp Arg  Gly Ile Lys Gly His  Arg Gly Phe 
    1100                 1105                 1110             


Ser Gly  Leu Gln Gly Pro Pro  Gly Pro Pro Gly Ser  Pro Gly Glu 
    1115                 1120                 1125             


Gln Gly  Pro Ser Gly Ala Ser  Gly Pro Ala Gly Pro  Arg Gly Pro 
    1130                 1135                 1140             


Pro Gly  Ser Ala Gly Ala Pro  Gly Lys Asp Gly Leu  Asn Gly Leu 
    1145                 1150                 1155             


Pro Gly  Pro Ile Gly Pro Pro  Gly Pro Arg Gly Arg  Thr Gly Asp 
    1160                 1165                 1170             


Ala Gly  Pro Val Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1175                 1180                 1185             


Pro Gly  Pro Pro Ser Ala Gly  Phe Asp Phe Ser Phe  Leu Pro Gln 
    1190                 1195                 1200             


Pro Pro  Gln Glu Lys Ala His  Asp Gly Gly Arg Tyr  Tyr Arg Ala 
    1205                 1210                 1215             


Asp Asp  Ala Asn Val Val Arg  Asp Arg Asp Leu Glu  Val Asp Thr 
    1220                 1225                 1230             


Thr Leu  Lys Ser Leu Ser Gln  Gln Ile Glu Asn Ile  Arg Ser Pro 
    1235                 1240                 1245             


Glu Gly  Ser Arg Lys Asn Pro  Ala Arg Thr Cys Arg  Asp Leu Lys 
    1250                 1255                 1260             


Met Cys  His Ser Asp Trp Lys  Ser Gly Glu Tyr Trp  Ile Asp Pro 
    1265                 1270                 1275             


Asn Gln  Gly Cys Asn Leu Asp  Ala Ile Lys Val Phe  Cys Asn Met 
    1280                 1285                 1290             


Glu Thr  Gly Glu Thr Cys Val  Tyr Pro Thr Gln Pro  Ser Val Ala 
    1295                 1300                 1305             


Gln Lys  Asn Trp Tyr Ile Ser  Lys Asn Pro Lys Asp  Lys Arg His 
    1310                 1315                 1320             


Val Trp  Phe Gly Glu Ser Met  Thr Asp Gly Phe Gln  Phe Glu Tyr 
    1325                 1330                 1335             


Gly Gly  Gln Gly Ser Asp Pro  Ala Asp Val Ala Ile  Gln Leu Thr 
    1340                 1345                 1350             


Phe Leu  Arg Leu Met Ser Thr  Glu Ala Ser Gln Asn  Ile Thr Tyr 
    1355                 1360                 1365             


His Cys  Lys Asn Ser Val Ala  Tyr Met Asp Gln Gln  Thr Gly Asn 
    1370                 1375                 1380             


Leu Lys  Lys Ala Leu Leu Leu  Gln Gly Ser Asn Glu  Ile Glu Ile 
    1385                 1390                 1395             


Arg Ala  Glu Gly Asn Ser Arg  Phe Thr Tyr Ser Val  Thr Val Asp 
    1400                 1405                 1410             


Gly Cys  Thr Ser His Thr Gly  Ala Trp Gly Lys Thr  Val Ile Glu 
    1415                 1420                 1425             


Tyr Lys  Thr Thr Lys Thr Ser  Arg Leu Pro Ile Ile  Asp Val Ala 
    1430                 1435                 1440             


Pro Leu  Asp Val Gly Ala Pro  Asp Gln Glu Phe Gly  Phe Asp Val 
    1445                 1450                 1455             


Gly Pro  Val Cys Phe Leu 
    1460                 


<210>  153
<211>  1838
<212>  PRT
<213>  Homo sapiens

<400>  153

Met Asp Val His Thr Arg Trp Lys Ala Arg Ser Ala Leu Arg Pro Gly 
1               5                   10                  15      


Ala Pro Leu Leu Pro Pro Leu Leu Leu Leu Leu Leu Trp Ala Pro Pro 
            20                  25                  30          


Pro Ser Arg Ala Ala Gln Pro Ala Asp Leu Leu Lys Val Leu Asp Phe 
        35                  40                  45              


His Asn Leu Pro Asp Gly Ile Thr Lys Thr Thr Gly Phe Cys Ala Thr 
    50                  55                  60                  


Arg Arg Ser Ser Lys Gly Pro Asp Val Ala Tyr Arg Val Thr Lys Asp 
65                  70                  75                  80  


Ala Gln Leu Ser Ala Pro Thr Lys Gln Leu Tyr Pro Ala Ser Ala Phe 
                85                  90                  95      


Pro Glu Asp Phe Ser Ile Leu Thr Thr Val Lys Ala Lys Lys Gly Ser 
            100                 105                 110         


Gln Ala Phe Leu Val Ser Ile Tyr Asn Glu Gln Gly Ile Gln Gln Ile 
        115                 120                 125             


Gly Leu Glu Leu Gly Arg Ser Pro Val Phe Leu Tyr Glu Asp His Thr 
    130                 135                 140                 


Gly Lys Pro Gly Pro Glu Asp Tyr Pro Leu Phe Arg Gly Ile Asn Leu 
145                 150                 155                 160 


Ser Asp Gly Lys Trp His Arg Ile Ala Leu Ser Val His Lys Lys Asn 
                165                 170                 175     


Val Thr Leu Ile Leu Asp Cys Lys Lys Lys Thr Thr Lys Phe Leu Asp 
            180                 185                 190         


Arg Ser Asp His Pro Met Ile Asp Ile Asn Gly Ile Ile Val Phe Gly 
        195                 200                 205             


Thr Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Leu 
    210                 215                 220                 


Leu Phe Val Ser Asp His Arg Ala Ala Tyr Asp Tyr Cys Glu His Tyr 
225                 230                 235                 240 


Ser Pro Asp Cys Asp Thr Ala Val Pro Asp Thr Pro Gln Ser Gln Asp 
                245                 250                 255     


Pro Asn Pro Asp Glu Tyr Tyr Thr Glu Gly Asp Gly Glu Gly Glu Thr 
            260                 265                 270         


Tyr Tyr Tyr Glu Tyr Pro Tyr Tyr Glu Asp Pro Glu Asp Leu Gly Lys 
        275                 280                 285             


Glu Pro Thr Pro Ser Lys Lys Pro Val Glu Ala Ala Lys Glu Thr Thr 
    290                 295                 300                 


Glu Val Pro Glu Glu Leu Thr Pro Thr Pro Thr Glu Ala Ala Pro Met 
305                 310                 315                 320 


Pro Glu Thr Ser Glu Gly Ala Gly Lys Glu Glu Asp Val Gly Ile Gly 
                325                 330                 335     


Asp Tyr Asp Tyr Val Pro Ser Glu Asp Tyr Tyr Thr Pro Ser Pro Tyr 
            340                 345                 350         


Asp Asp Leu Thr Tyr Gly Glu Gly Glu Glu Asn Pro Asp Gln Pro Thr 
        355                 360                 365             


Asp Pro Gly Ala Gly Ala Glu Ile Pro Thr Ser Thr Ala Asp Thr Ser 
    370                 375                 380                 


Asn Ser Ser Asn Pro Ala Pro Pro Pro Gly Glu Gly Ala Asp Asp Leu 
385                 390                 395                 400 


Glu Gly Glu Phe Thr Glu Glu Thr Ile Arg Asn Leu Asp Glu Asn Tyr 
                405                 410                 415     


Tyr Asp Pro Tyr Tyr Asp Pro Thr Ser Ser Pro Ser Glu Ile Gly Pro 
            420                 425                 430         


Gly Met Pro Ala Asn Gln Asp Thr Ile Tyr Glu Gly Ile Gly Gly Pro 
        435                 440                 445             


Arg Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala Ile Ile Glu Pro Gly 
    450                 455                 460                 


Met Leu Ile Glu Gly Pro Pro Gly Pro Glu Gly Pro Ala Gly Leu Pro 
465                 470                 475                 480 


Gly Pro Pro Gly Thr Met Gly Pro Thr Gly Gln Val Gly Asp Pro Gly 
                485                 490                 495     


Glu Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp Gly Leu 
            500                 505                 510         


Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Phe Gly Gly 
        515                 520                 525             


Gly Gly Asp Ala Gly Ser Lys Gly Pro Met Val Ser Ala Gln Glu Ser 
    530                 535                 540                 


Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg Gly Pro 
545                 550                 555                 560 


Ala Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Pro Pro 
                565                 570                 575     


Gly Ser Gly Gly Leu Lys Gly Glu Pro Gly Asp Val Gly Pro Gln Gly 
            580                 585                 590         


Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Ala Gly Lys Pro Gly Arg 
        595                 600                 605             


Arg Gly Arg Ala Gly Ser Asp Gly Ala Arg Gly Met Pro Gly Gln Thr 
    610                 615                 620                 


Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Ala Gly Leu Pro Gly 
625                 630                 635                 640 


Glu Lys Gly His Arg Gly Asp Pro Gly Pro Ser Gly Pro Pro Gly Pro 
                645                 650                 655     


Pro Gly Asp Asp Gly Glu Arg Gly Asp Asp Gly Glu Val Gly Pro Arg 
            660                 665                 670         


Gly Leu Pro Gly Glu Pro Gly Pro Arg Gly Leu Leu Gly Pro Lys Gly 
        675                 680                 685             


Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Thr Gly Met Asp Gly Gln 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asn Val Gly Pro Gln Gly Glu Pro Gly Pro Pro 
705                 710                 715                 720 


Gly Gln Gln Gly Asn Pro Gly Ala Gln Gly Leu Pro Gly Pro Gln Gly 
                725                 730                 735     


Ala Ile Gly Pro Pro Gly Glu Lys Gly Pro Leu Gly Lys Pro Gly Leu 
            740                 745                 750         


Pro Gly Met Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly Lys Glu 
        755                 760                 765             


Gly Pro Pro Gly Glu Lys Gly Gly Gln Gly Pro Pro Gly Pro Gln Gly 
    770                 775                 780                 


Pro Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp Gly Ile 
785                 790                 795                 800 


Arg Gly Leu Lys Gly Thr Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro 
                805                 810                 815     


Gly Phe Lys Gly Asp Met Gly Ile Lys Gly Asp Arg Gly Glu Ile Gly 
            820                 825                 830         


Pro Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg 
        835                 840                 845             


Gly Gly Pro Asn Gly Asp Pro Gly Pro Leu Gly Pro Pro Gly Glu Lys 
    850                 855                 860                 


Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly 
865                 870                 875                 880 


Pro Lys Gly Ser Ile Gly Phe Pro Gly Phe Pro Gly Ala Asn Gly Glu 
                885                 890                 895     


Lys Gly Gly Arg Gly Thr Pro Gly Lys Pro Gly Pro Arg Gly Gln Arg 
            900                 905                 910         


Gly Pro Thr Gly Pro Arg Gly Glu Arg Gly Pro Arg Gly Ile Thr Gly 
        915                 920                 925             


Lys Pro Gly Pro Lys Gly Asn Ser Gly Gly Asp Gly Pro Ala Gly Pro 
    930                 935                 940                 


Pro Gly Glu Arg Gly Pro Asn Gly Pro Gln Gly Pro Thr Gly Phe Pro 
945                 950                 955                 960 


Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly 
                965                 970                 975     


His Pro Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr Gly Pro 
            980                 985                 990         


Pro Gly Pro Pro Gly Val Val Gly  Pro Gln Gly Pro Thr  Gly Glu Thr 
        995                 1000                 1005             


Gly Pro  Met Gly Glu Arg Gly  His Pro Gly Pro Pro  Gly Pro Pro 
    1010                 1015                 1020             


Gly Glu  Gln Gly Leu Pro Gly  Leu Ala Gly Lys Glu  Gly Thr Lys 
    1025                 1030                 1035             


Gly Asp  Pro Gly Pro Ala Gly  Leu Pro Gly Lys Asp  Gly Pro Pro 
    1040                 1045                 1050             


Gly Leu  Arg Gly Phe Pro Gly  Asp Arg Gly Leu Pro  Gly Pro Val 
    1055                 1060                 1065             


Gly Ala  Leu Gly Leu Lys Gly  Asn Glu Gly Pro Pro  Gly Pro Pro 
    1070                 1075                 1080             


Gly Pro  Ala Gly Ser Pro Gly  Glu Arg Gly Pro Ala  Gly Ala Ala 
    1085                 1090                 1095             


Gly Pro  Ile Gly Ile Pro Gly  Arg Pro Gly Pro Gln  Gly Pro Pro 
    1100                 1105                 1110             


Gly Pro  Ala Gly Glu Lys Gly  Ala Pro Gly Glu Lys  Gly Pro Gln 
    1115                 1120                 1125             


Gly Pro  Ala Gly Arg Asp Gly  Leu Gln Gly Pro Val  Gly Leu Pro 
    1130                 1135                 1140             


Gly Pro  Ala Gly Pro Val Gly  Pro Pro Gly Glu Asp  Gly Asp Lys 
    1145                 1150                 1155             


Gly Glu  Ile Gly Glu Pro Gly  Gln Lys Gly Ser Lys  Gly Asp Lys 
    1160                 1165                 1170             


Gly Glu  Gln Gly Pro Pro Gly  Pro Thr Gly Pro Gln  Gly Pro Ile 
    1175                 1180                 1185             


Gly Gln  Pro Gly Pro Ser Gly  Ala Asp Gly Glu Pro  Gly Pro Arg 
    1190                 1195                 1200             


Gly Gln  Gln Gly Leu Phe Gly  Gln Lys Gly Asp Glu  Gly Pro Arg 
    1205                 1210                 1215             


Gly Phe  Pro Gly Pro Pro Gly  Pro Val Gly Leu Gln  Gly Leu Pro 
    1220                 1225                 1230             


Gly Pro  Pro Gly Glu Lys Gly  Glu Thr Gly Asp Val  Gly Gln Met 
    1235                 1240                 1245             


Gly Pro  Pro Gly Pro Pro Gly  Pro Arg Gly Pro Ser  Gly Ala Pro 
    1250                 1255                 1260             


Gly Ala  Asp Gly Pro Gln Gly  Pro Pro Gly Gly Ile  Gly Asn Pro 
    1265                 1270                 1275             


Gly Ala  Val Gly Glu Lys Gly  Glu Pro Gly Glu Ala  Gly Glu Pro 
    1280                 1285                 1290             


Gly Leu  Pro Gly Glu Gly Gly  Pro Pro Gly Pro Lys  Gly Glu Arg 
    1295                 1300                 1305             


Gly Glu  Lys Gly Glu Ser Gly  Pro Ser Gly Ala Ala  Gly Pro Pro 
    1310                 1315                 1320             


Gly Pro  Lys Gly Pro Pro Gly  Asp Asp Gly Pro Lys  Gly Ser Pro 
    1325                 1330                 1335             


Gly Pro  Val Gly Phe Pro Gly  Asp Pro Gly Pro Pro  Gly Glu Pro 
    1340                 1345                 1350             


Gly Pro  Ala Gly Gln Asp Gly  Pro Pro Gly Asp Lys  Gly Asp Asp 
    1355                 1360                 1365             


Gly Glu  Pro Gly Gln Thr Gly  Ser Pro Gly Pro Thr  Gly Glu Pro 
    1370                 1375                 1380             


Gly Pro  Ser Gly Pro Pro Gly  Lys Arg Gly Pro Pro  Gly Pro Ala 
    1385                 1390                 1395             


Gly Pro  Glu Gly Arg Gln Gly  Glu Lys Gly Ala Lys  Gly Glu Ala 
    1400                 1405                 1410             


Gly Leu  Glu Gly Pro Pro Gly  Lys Thr Gly Pro Ile  Gly Pro Gln 
    1415                 1420                 1425             


Gly Ala  Pro Gly Lys Pro Gly  Pro Asp Gly Leu Arg  Gly Ile Pro 
    1430                 1435                 1440             


Gly Pro  Val Gly Glu Gln Gly  Leu Pro Gly Ser Pro  Gly Pro Asp 
    1445                 1450                 1455             


Gly Pro  Pro Gly Pro Met Gly  Pro Pro Gly Leu Pro  Gly Leu Lys 
    1460                 1465                 1470             


Gly Asp  Ser Gly Pro Lys Gly  Glu Lys Gly His Pro  Gly Leu Ile 
    1475                 1480                 1485             


Gly Leu  Ile Gly Pro Pro Gly  Glu Gln Gly Glu Lys  Gly Asp Arg 
    1490                 1495                 1500             


Gly Leu  Pro Gly Pro Gln Gly  Ser Ser Gly Pro Lys  Gly Glu Gln 
    1505                 1510                 1515             


Gly Ile  Thr Gly Pro Ser Gly  Pro Ile Gly Pro Pro  Gly Pro Pro 
    1520                 1525                 1530             


Gly Leu  Pro Gly Pro Pro Gly  Pro Lys Gly Ala Lys  Gly Ser Ser 
    1535                 1540                 1545             


Gly Pro  Thr Gly Pro Lys Gly  Glu Ala Gly His Pro  Gly Pro Pro 
    1550                 1555                 1560             


Gly Pro  Pro Gly Pro Pro Gly  Glu Val Ile Gln Pro  Leu Pro Ile 
    1565                 1570                 1575             


Gln Ala  Ser Arg Thr Arg Arg  Asn Ile Asp Ala Ser  Gln Leu Leu 
    1580                 1585                 1590             


Asp Asp  Gly Asn Gly Glu Asn  Tyr Val Asp Tyr Ala  Asp Gly Met 
    1595                 1600                 1605             


Glu Glu  Ile Phe Gly Ser Leu  Asn Ser Leu Lys Leu  Glu Ile Glu 
    1610                 1615                 1620             


Gln Met  Lys Arg Pro Leu Gly  Thr Gln Gln Asn Pro  Ala Arg Thr 
    1625                 1630                 1635             


Cys Lys  Asp Leu Gln Leu Cys  His Pro Asp Phe Pro  Asp Gly Glu 
    1640                 1645                 1650             


Tyr Trp  Val Asp Pro Asn Gln  Gly Cys Ser Arg Asp  Ser Phe Lys 
    1655                 1660                 1665             


Val Tyr  Cys Asn Phe Thr Ala  Gly Gly Ser Thr Cys  Val Phe Pro 
    1670                 1675                 1680             


Asp Lys  Lys Ser Glu Gly Ala  Arg Ile Thr Ser Trp  Pro Lys Glu 
    1685                 1690                 1695             


Asn Pro  Gly Ser Trp Phe Ser  Glu Phe Lys Arg Gly  Lys Leu Leu 
    1700                 1705                 1710             


Ser Tyr  Val Asp Ala Glu Gly  Asn Pro Val Gly Val  Val Gln Met 
    1715                 1720                 1725             


Thr Phe  Leu Arg Leu Leu Ser  Ala Ser Ala His Gln  Asn Val Thr 
    1730                 1735                 1740             


Tyr His  Cys Tyr Gln Ser Val  Ala Trp Gln Asp Ala  Ala Thr Gly 
    1745                 1750                 1755             


Ser Tyr  Asp Lys Ala Leu Arg  Phe Leu Gly Ser Asn  Asp Glu Glu 
    1760                 1765                 1770             


Met Ser  Tyr Asp Asn Asn Pro  Tyr Ile Arg Ala Leu  Val Asp Gly 
    1775                 1780                 1785             


Cys Ala  Thr Lys Lys Gly Tyr  Gln Lys Thr Val Leu  Glu Ile Asp 
    1790                 1795                 1800             


Thr Pro  Lys Val Glu Gln Val  Pro Ile Val Asp Ile  Met Phe Asn 
    1805                 1810                 1815             


Asp Phe  Gly Glu Ala Ser Gln  Lys Phe Gly Phe Glu  Val Gly Pro 
    1820                 1825                 1830             


Ala Cys  Phe Met Gly 
    1835             


<210>  154
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  154

Met Gly Lys Asp Tyr Tyr Cys Ile Leu Gly Ile Glu Lys Gly Ala Ser 
1               5                   10                  15      


Asp Glu Asp Ile Lys Lys Ala Tyr Arg Lys Gln Ala Leu Lys Phe His 
            20                  25                  30          


Pro Asp Lys Asn Lys Ser Pro Gln Ala Glu Glu Lys Phe Lys Glu Val 
        35                  40                  45              


Ala Glu Ala Tyr Glu Val Leu Ser Asp Pro Lys Lys Arg Glu Ile Tyr 
    50                  55                  60                  


Asp Gln Phe Gly Glu Glu Gly Leu Lys Gly Gly Ala Gly Gly Thr Asp 
65                  70                  75                  80  


Gly Gln Gly Gly Thr Phe Arg Tyr Thr Phe His Gly Asp Pro His Ala 
                85                  90                  95      


Thr Phe Ala Ala Phe Phe Gly Gly Ser Asn Pro Phe Glu Ile Phe Phe 
            100                 105                 110         


Gly Arg Arg Met Gly Gly Gly Arg Asp Ser Glu Glu Met Glu Ile Asp 
        115                 120                 125             


Gly Asp Pro Phe Ser Ala Phe Gly Phe Ser Met Asn Gly Tyr Pro Arg 
    130                 135                 140                 


Asp Arg Asn Ser Val Gly Pro Ser Arg Leu Lys Gln Asp Pro Pro Val 
145                 150                 155                 160 


Ile His Glu Leu Arg Val Ser Leu Glu Glu Ile Tyr Ser Gly Cys Thr 
                165                 170                 175     


Lys Arg Met Lys Ile Ser Arg Lys Arg Leu Asn Ala Asp Gly Arg Ser 
            180                 185                 190         


Tyr Arg Ser Glu Asp Lys Ile Leu Thr Ile Glu Ile Lys Lys Gly Trp 
        195                 200                 205             


Lys Glu Gly Thr Lys Ile Thr Phe Pro Arg Glu Gly Asp Glu Thr Pro 
    210                 215                 220                 


Asn Ser Ile Pro Ala Asp Ile Val Phe Ile Ile Lys Asp Lys Asp His 
225                 230                 235                 240 


Pro Lys Phe Lys Arg Asp Gly Ser Asn Ile Ile Tyr Thr Ala Lys Ile 
                245                 250                 255     


Ser Leu Arg Glu Ala Leu Cys Gly Cys Ser Ile Asn Val Pro Thr Leu 
            260                 265                 270         


Asp Gly Arg Asn Ile Pro Met Ser Val Asn Asp Ile Val Lys Pro Gly 
        275                 280                 285             


Met Arg Arg Arg Ile Ile Gly Tyr Gly Leu Pro Phe Pro Lys Asn Pro 
    290                 295                 300                 


Asp Gln Arg Gly Asp Leu Leu Ile Glu Phe Glu Val Ser Phe Pro Asp 
305                 310                 315                 320 


Thr Ile Ser Ser Ser Ser Lys Glu Val Leu Arg Lys His Leu Pro Ala 
                325                 330                 335     


Ser 
    


<210>  155
<211>  1170
<212>  PRT
<213>  Homo sapiens

<400>  155

Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr Asn Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 
            20                  25                  30          


Ile Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 
        35                  40                  45              


Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala 
    50                  55                  60                  


Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu Val Asp 
65                  70                  75                  80  


Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala Ser Leu Arg Gln 
                85                  90                  95      


Met Lys Lys Thr Arg Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His 
            100                 105                 110         


Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu 
        115                 120                 125             


Asp Leu Ser Leu Thr Val Gln Gly Lys Gln His Val Val Ser Val Glu 
    130                 135                 140                 


Glu Ala Leu Leu Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 
145                 150                 155                 160 


Gln Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 
                165                 170                 175     


Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala 
            180                 185                 190         


Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe 
        195                 200                 205             


Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu 
    210                 215                 220                 


Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu 
225                 230                 235                 240 


Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr 
                245                 250                 255     


Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 
            260                 265                 270         


Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 
        275                 280                 285             


Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 
    290                 295                 300                 


Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His 
305                 310                 315                 320 


Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys 
                325                 330                 335     


Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser 
            340                 345                 350         


Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys 
        355                 360                 365             


Cys Pro Arg Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro 
    370                 375                 380                 


Trp Ser Glu Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln 
385                 390                 395                 400 


Gln Arg Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser 
                405                 410                 415     


Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe 
            420                 425                 430         


Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser 
        435                 440                 445             


Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser 
    450                 455                 460                 


Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu 
465                 470                 475                 480 


Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly 
                485                 490                 495     


Pro Trp Ser Pro Trp Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val 
            500                 505                 510         


Gln Lys Arg Ser Arg Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly 
        515                 520                 525             


Lys Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln 
    530                 535                 540                 


Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val 
545                 550                 555                 560 


Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro 
                565                 570                 575     


Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys 
            580                 585                 590         


Lys Glu Val Pro Asp Ala Cys Phe Asn His Asn Gly Glu His Arg Cys 
        595                 600                 605             


Glu Asn Thr Asp Pro Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe 
    610                 615                 620                 


Thr Gly Ser Gln Pro Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn 
625                 630                 635                 640 


Lys Gln Val Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp 
                645                 650                 655     


Cys Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro 
            660                 665                 670         


Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile 
        675                 680                 685             


Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val 
    690                 695                 700                 


Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn 
705                 710                 715                 720 


Leu Pro Asn Ser Gly Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp 
                725                 730                 735     


Ala Cys Asp Asp Asp Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp 
            740                 745                 750         


Asn Cys Pro Phe His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp 
        755                 760                 765             


Asp Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp 
    770                 775                 780                 


Gln Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp 
785                 790                 795                 800 


Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val 
                805                 810                 815     


Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln 
            820                 825                 830         


Cys Asp Asn Cys Pro Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp 
        835                 840                 845             


Ser Asp Arg Ile Gly Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu 
    850                 855                 860                 


Asp Gly His Gln Asn Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala 
865                 870                 875                 880 


Asn Gln Ala Asp His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His 
                885                 890                 895     


Asp Asp Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu 
            900                 905                 910         


Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp 
        915                 920                 925             


Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp 
    930                 935                 940                 


Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe 
945                 950                 955                 960 


Gln Met Ile Pro Leu Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn 
                965                 970                 975     


Trp Val Val Arg His Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys 
            980                 985                 990         


Asp Pro Gly Leu Ala Val Gly Tyr  Asp Glu Phe Asn Ala  Val Asp Phe 
        995                 1000                 1005             


Ser Gly  Thr Phe Phe Ile Asn  Thr Glu Arg Asp Asp  Asp Tyr Ala 
    1010                 1015                 1020             


Gly Phe  Val Phe Gly Tyr Gln  Ser Ser Ser Arg Phe  Tyr Val Val 
    1025                 1030                 1035             


Met Trp  Lys Gln Val Thr Gln  Ser Tyr Trp Asp Thr  Asn Pro Thr 
    1040                 1045                 1050             


Arg Ala  Gln Gly Tyr Ser Gly  Leu Ser Val Lys Val  Val Asn Ser 
    1055                 1060                 1065             


Thr Thr  Gly Pro Gly Glu His  Leu Arg Asn Ala Leu  Trp His Thr 
    1070                 1075                 1080             


Gly Asn  Thr Pro Gly Gln Val  Arg Thr Leu Trp His  Asp Pro Arg 
    1085                 1090                 1095             


His Ile  Gly Trp Lys Asp Phe  Thr Ala Tyr Arg Trp  Arg Leu Ser 
    1100                 1105                 1110             


His Arg  Pro Lys Thr Gly Phe  Ile Arg Val Val Met  Tyr Glu Gly 
    1115                 1120                 1125             


Lys Lys  Ile Met Ala Asp Ser  Gly Pro Ile Tyr Asp  Lys Thr Tyr 
    1130                 1135                 1140             


Ala Gly  Gly Arg Leu Gly Leu  Phe Val Phe Ser Gln  Glu Met Val 
    1145                 1150                 1155             


Phe Phe  Ser Asp Leu Lys Tyr  Glu Cys Arg Asp Pro  
    1160                 1165                 1170 


<210>  156
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  156

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu 
    


<210>  157
<211>  1366
<212>  PRT
<213>  Homo sapiens

<400>  157

Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr 
1               5                   10                  15      


Leu Cys Leu Ala Thr Cys Gln Ser Leu Gln Glu Glu Thr Val Arg Lys 
            20                  25                  30          


Gly Pro Ala Gly Asp Arg Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly 
        35                  40                  45              


Pro Pro Gly Arg Asp Gly Glu Asp Gly Pro Thr Gly Pro Pro Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala Gln 
65                  70                  75                  80  


Tyr Asp Gly Lys Gly Val Gly Leu Gly Pro Gly Pro Met Gly Leu Met 
                85                  90                  95      


Gly Pro Arg Gly Pro Pro Gly Ala Ala Gly Ala Pro Gly Pro Gln Gly 
            100                 105                 110         


Phe Gln Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Gln Thr Gly Pro 
        115                 120                 125             


Ala Gly Ala Arg Gly Pro Ala Gly Pro Pro Gly Lys Ala Gly Glu Asp 
    130                 135                 140                 


Gly His Pro Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Val Val Gly 
145                 150                 155                 160 


Pro Gln Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Phe 
                165                 170                 175     


Lys Gly Ile Arg Gly His Asn Gly Leu Asp Gly Leu Lys Gly Gln Pro 
            180                 185                 190         


Gly Ala Pro Gly Val Lys Gly Glu Pro Gly Ala Pro Gly Glu Asn Gly 
        195                 200                 205             


Thr Pro Gly Gln Thr Gly Ala Arg Gly Leu Pro Gly Glu Arg Gly Arg 
    210                 215                 220                 


Val Gly Ala Pro Gly Pro Ala Gly Ala Arg Gly Ser Asp Gly Ser Val 
225                 230                 235                 240 


Gly Pro Val Gly Pro Ala Gly Pro Ile Gly Ser Ala Gly Pro Pro Gly 
                245                 250                 255     


Phe Pro Gly Ala Pro Gly Pro Lys Gly Glu Ile Gly Ala Val Gly Asn 
            260                 265                 270         


Ala Gly Pro Ala Gly Pro Ala Gly Pro Arg Gly Glu Val Gly Leu Pro 
        275                 280                 285             


Gly Leu Ser Gly Pro Val Gly Pro Pro Gly Asn Pro Gly Ala Asn Gly 
    290                 295                 300                 


Leu Thr Gly Ala Lys Gly Ala Ala Gly Leu Pro Gly Val Ala Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Pro Gly Pro Arg Gly Ile Pro Gly Pro Val Gly Ala Ala 
                325                 330                 335     


Gly Ala Thr Gly Ala Arg Gly Leu Val Gly Glu Pro Gly Pro Ala Gly 
            340                 345                 350         


Ser Lys Gly Glu Ser Gly Asn Lys Gly Glu Pro Gly Ser Ala Gly Pro 
        355                 360                 365             


Gln Gly Pro Pro Gly Pro Ser Gly Glu Glu Gly Lys Arg Gly Pro Asn 
    370                 375                 380                 


Gly Glu Ala Gly Ser Ala Gly Pro Pro Gly Pro Pro Gly Leu Arg Gly 
385                 390                 395                 400 


Ser Pro Gly Ser Arg Gly Leu Pro Gly Ala Asp Gly Arg Ala Gly Val 
                405                 410                 415     


Met Gly Pro Pro Gly Ser Arg Gly Ala Ser Gly Pro Ala Gly Val Arg 
            420                 425                 430         


Gly Pro Asn Gly Asp Ala Gly Arg Pro Gly Glu Pro Gly Leu Met Gly 
        435                 440                 445             


Pro Arg Gly Leu Pro Gly Ser Pro Gly Asn Ile Gly Pro Ala Gly Lys 
    450                 455                 460                 


Glu Gly Pro Val Gly Leu Pro Gly Ile Asp Gly Arg Pro Gly Pro Ile 
465                 470                 475                 480 


Gly Pro Ala Gly Ala Arg Gly Glu Pro Gly Asn Ile Gly Phe Pro Gly 
                485                 490                 495     


Pro Lys Gly Pro Thr Gly Asp Pro Gly Lys Asn Gly Asp Lys Gly His 
            500                 505                 510         


Ala Gly Leu Ala Gly Ala Arg Gly Ala Pro Gly Pro Asp Gly Asn Asn 
        515                 520                 525             


Gly Ala Gln Gly Pro Pro Gly Pro Gln Gly Val Gln Gly Gly Lys Gly 
    530                 535                 540                 


Glu Gln Gly Pro Pro Gly Pro Pro Gly Phe Gln Gly Leu Pro Gly Pro 
545                 550                 555                 560 


Ser Gly Pro Ala Gly Glu Val Gly Lys Pro Gly Glu Arg Gly Leu His 
                565                 570                 575     


Gly Glu Phe Gly Leu Pro Gly Pro Ala Gly Pro Arg Gly Glu Arg Gly 
            580                 585                 590         


Pro Pro Gly Glu Ser Gly Ala Ala Gly Pro Thr Gly Pro Ile Gly Ser 
        595                 600                 605             


Arg Gly Pro Ser Gly Pro Pro Gly Pro Asp Gly Asn Lys Gly Glu Pro 
    610                 615                 620                 


Gly Val Val Gly Ala Val Gly Thr Ala Gly Pro Ser Gly Pro Ser Gly 
625                 630                 635                 640 


Leu Pro Gly Glu Arg Gly Ala Ala Gly Ile Pro Gly Gly Lys Gly Glu 
                645                 650                 655     


Lys Gly Glu Pro Gly Leu Arg Gly Glu Ile Gly Asn Pro Gly Arg Asp 
            660                 665                 670         


Gly Ala Arg Gly Ala Pro Gly Ala Val Gly Ala Pro Gly Pro Ala Gly 
        675                 680                 685             


Ala Thr Gly Asp Arg Gly Glu Ala Gly Ala Ala Gly Pro Ala Gly Pro 
    690                 695                 700                 


Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg Gly Glu Val Gly Pro Ala 
705                 710                 715                 720 


Gly Pro Asn Gly Phe Ala Gly Pro Ala Gly Ala Ala Gly Gln Pro Gly 
                725                 730                 735     


Ala Lys Gly Glu Arg Gly Ala Lys Gly Pro Lys Gly Glu Asn Gly Val 
            740                 745                 750         


Val Gly Pro Thr Gly Pro Val Gly Ala Ala Gly Pro Ala Gly Pro Asn 
        755                 760                 765             


Gly Pro Pro Gly Pro Ala Gly Ser Arg Gly Asp Gly Gly Pro Pro Gly 
    770                 775                 780                 


Met Thr Gly Phe Pro Gly Ala Ala Gly Arg Thr Gly Pro Pro Gly Pro 
785                 790                 795                 800 


Ser Gly Ile Ser Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys Glu 
                805                 810                 815     


Gly Leu Arg Gly Pro Arg Gly Asp Gln Gly Pro Val Gly Arg Thr Gly 
            820                 825                 830         


Glu Val Gly Ala Val Gly Pro Pro Gly Phe Ala Gly Glu Lys Gly Pro 
        835                 840                 845             


Ser Gly Glu Ala Gly Thr Ala Gly Pro Pro Gly Thr Pro Gly Pro Gln 
    850                 855                 860                 


Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly Leu Pro Gly Ser Arg Gly 
865                 870                 875                 880 


Glu Arg Gly Leu Pro Gly Val Ala Gly Ala Val Gly Glu Pro Gly Pro 
                885                 890                 895     


Leu Gly Ile Ala Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Ala Val 
            900                 905                 910         


Gly Ser Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg Asp Gly 
        915                 920                 925             


Asn Pro Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly Gln Pro Gly His 
    930                 935                 940                 


Lys Gly Glu Arg Gly Tyr Pro Gly Asn Ile Gly Pro Val Gly Ala Ala 
945                 950                 955                 960 


Gly Ala Pro Gly Pro His Gly Pro Val Gly Pro Ala Gly Lys His Gly 
                965                 970                 975     


Asn Arg Gly Glu Thr Gly Pro Ser Gly Pro Val Gly Pro Ala Gly Ala 
            980                 985                 990         


Val Gly Pro Arg Gly Pro Ser Gly  Pro Gln Gly Ile Arg  Gly Asp Lys 
        995                 1000                 1005             


Gly Glu  Pro Gly Glu Lys Gly  Pro Arg Gly Leu Pro  Gly Leu Lys 
    1010                 1015                 1020             


Gly His  Asn Gly Leu Gln Gly  Leu Pro Gly Ile Ala  Gly His His 
    1025                 1030                 1035             


Gly Asp  Gln Gly Ala Pro Gly  Ser Val Gly Pro Ala  Gly Pro Arg 
    1040                 1045                 1050             


Gly Pro  Ala Gly Pro Ser Gly  Pro Ala Gly Lys Asp  Gly Arg Thr 
    1055                 1060                 1065             


Gly His  Pro Gly Thr Val Gly  Pro Ala Gly Ile Arg  Gly Pro Gln 
    1070                 1075                 1080             


Gly His  Gln Gly Pro Ala Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1085                 1090                 1095             


Gly Pro  Pro Gly Val Ser Gly  Gly Gly Tyr Asp Phe  Gly Tyr Asp 
    1100                 1105                 1110             


Gly Asp  Phe Tyr Arg Ala Asp  Gln Pro Arg Ser Ala  Pro Ser Leu 
    1115                 1120                 1125             


Arg Pro  Lys Asp Tyr Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 
    1130                 1135                 1140             


Asn Gln  Ile Glu Thr Leu Leu  Thr Pro Glu Gly Ser  Arg Lys Asn 
    1145                 1150                 1155             


Pro Ala  Arg Thr Cys Arg Asp  Leu Arg Leu Ser His  Pro Glu Trp 
    1160                 1165                 1170             


Ser Ser  Gly Tyr Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Met 
    1175                 1180                 1185             


Asp Ala  Ile Lys Val Tyr Cys  Asp Phe Ser Thr Gly  Glu Thr Cys 
    1190                 1195                 1200             


Ile Arg  Ala Gln Pro Glu Asn  Ile Pro Ala Lys Asn  Trp Tyr Arg 
    1205                 1210                 1215             


Ser Ser  Lys Asp Lys Lys His  Val Trp Leu Gly Glu  Thr Ile Asn 
    1220                 1225                 1230             


Ala Gly  Ser Gln Phe Glu Tyr  Asn Val Glu Gly Val  Thr Ser Lys 
    1235                 1240                 1245             


Glu Met  Ala Thr Gln Leu Ala  Phe Met Arg Leu Leu  Ala Asn Tyr 
    1250                 1255                 1260             


Ala Ser  Gln Asn Ile Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr 
    1265                 1270                 1275             


Met Asp  Glu Glu Thr Gly Asn  Leu Lys Lys Ala Val  Ile Leu Gln 
    1280                 1285                 1290             


Gly Ser  Asn Asp Val Glu Leu  Val Ala Glu Gly Asn  Ser Arg Phe 
    1295                 1300                 1305             


Thr Tyr  Thr Val Leu Val Asp  Gly Cys Ser Lys Lys  Thr Asn Glu 
    1310                 1315                 1320             


Trp Gly  Lys Thr Ile Ile Glu  Tyr Lys Thr Asn Lys  Pro Ser Arg 
    1325                 1330                 1335             


Leu Pro  Phe Leu Asp Ile Ala  Pro Leu Asp Ile Gly  Gly Ala Asp 
    1340                 1345                 1350             


Gln Glu  Phe Phe Val Asp Ile  Gly Pro Val Cys Phe  Lys 
    1355                 1360                 1365     


