                         SEQUENCE LISTING

<110>  INSTITUT PASTEUR
 
<120>  PLAGUE VACCINE

<130>  B10007 - FP/BA

<160>  18    

<170>  PatentIn version 3.3

<210>  1
<211>  34
<212>  DNA
<213>  Yersinia pestis

<400>  1
ataagaatga attcgtgact gatcaatatg ttgg                                 34


<210>  2
<211>  31
<212>  DNA
<213>  Yersinia pestis

<400>  2
cgttagggcc cgtcagtctt gctatcaatg c                                    31


<210>  3
<211>  19
<212>  DNA
<213>  Yersinia pestis

<400>  3
caggaaccac tagcacatc                                                  19


<210>  4
<211>  18
<212>  DNA
<213>  Yersinia pestis

<400>  4
cccccacaag gttctcac                                                   18


<210>  5
<211>  23
<212>  DNA
<213>  Yersinia pestis

<400>  5
cacagcataa ctggactgat ttc                                             23


<210>  6
<211>  26
<212>  DNA
<213>  Yersinia pestis

<400>  6
gctatacgtg tttgctgatc aagatg                                          26


<210>  7
<211>  22
<212>  DNA
<213>  Yersinia pestis

<400>  7
attagcttac gacgctacac cc                                              22


<210>  8
<211>  24
<212>  DNA
<213>  Yersinia pestis

<400>  8
acgccaccgg aagaaccgat acct                                            24


<210>  9
<211>  513
<212>  DNA
<213>  Yersinia pestis

<400>  9
atgaaaaaaa tcagttccgt tatcgccatt gcattatttg gaactattgc aactgctaat     60

gcggcagatt taactgcaag caccactgca acggcaactc ttgttgaacc agcccgcatc    120

actcttacat ataaggaagg cgctccaatt acaattatgg acaatggaaa catcgataca    180

gaattacttg ttggtacgct tactcttggc ggctataaaa caggaaccac tagcacatct    240

gttaacttta cagatgccgc gggtgatccc atgtacttaa catttacttc tcaggatgga    300

aataaccacc aattcactac aaaagtgatt ggcaaggatt ctagagattt tgatatctct    360

cctaaggtaa acggtgagaa ccttgtgggg gatgacgtcg tcttggctac gggcagccag    420

gatttctttg ttcgctcaat tggttccaaa ggcggtaaac ttgcagcagg taaatacact    480

gatgctgtaa ccgtaaccgt atctaaccaa taa                                 513


<210>  10
<211>  170
<212>  PRT
<213>  Yersinia pestis

<400>  10

Met Lys Lys Ile Ser Ser Val Ile Ala Ile Ala Leu Phe Gly Thr Ile 
1               5                   10                  15      


Ala Thr Ala Asn Ala Ala Asp Leu Thr Ala Ser Thr Thr Ala Thr Ala 
            20                  25                  30          


Thr Leu Val Glu Pro Ala Arg Ile Thr Leu Thr Tyr Lys Glu Gly Ala 
        35                  40                  45              


Pro Ile Thr Ile Met Asp Asn Gly Asn Ile Asp Thr Glu Leu Leu Val 
    50                  55                  60                  


Gly Thr Leu Thr Leu Gly Gly Tyr Lys Thr Gly Thr Thr Ser Thr Ser 
65                  70                  75                  80  


Val Asn Phe Thr Asp Ala Ala Gly Asp Pro Met Tyr Leu Thr Phe Thr 
                85                  90                  95      


Ser Gln Asp Gly Asn Asn His Gln Phe Thr Thr Lys Val Ile Gly Lys 
            100                 105                 110         


Asp Ser Arg Asp Phe Asp Ile Ser Pro Lys Val Asn Gly Glu Asn Leu 
        115                 120                 125             


Val Gly Asp Asp Val Val Leu Ala Thr Gly Ser Gln Asp Phe Phe Val 
    130                 135                 140                 


Arg Ser Ile Gly Ser Lys Gly Gly Lys Leu Ala Ala Gly Lys Tyr Thr 
145                 150                 155                 160 


Asp Ala Val Thr Val Thr Val Ser Asn Gln 
                165                 170 


<210>  11
<211>  450
<212>  DNA
<213>  Yersinia pestis

<400>  11
gcagatttaa ctgcaagcac cactgcaacg gcaactcttg ttgaaccagc ccgcatcact     60

cttacatata aggaaggcgc tccaattaca attatggaca atggaaacat cgatacagaa    120

ttacttgttg gtacgcttac tcttggcggc tataaaacag gaaccactag cacatctgtt    180

aactttacag atgccgcggg tgatcccatg tacttaacat ttacttctca ggatggaaat    240

aaccaccaat tcactacaaa agtgattggc aaggattcta gagattttga tatctctcct    300

aaggtaaacg gtgagaacct tgtgggggat gacgtcgtct tggctacggg cagccaggat    360

ttctttgttc gctcaattgg ttccaaaggc ggtaaacttg cagcaggtaa atacactgat    420

gctgtaaccg taaccgtatc taaccaataa                                     450


<210>  12
<211>  149
<212>  PRT
<213>  Yersinia pestis

<400>  12

Ala Asp Leu Thr Ala Ser Thr Thr Ala Thr Ala Thr Leu Val Glu Pro 
1               5                   10                  15      


Ala Arg Ile Thr Leu Thr Tyr Lys Glu Gly Ala Pro Ile Thr Ile Met 
            20                  25                  30          


Asp Asn Gly Asn Ile Asp Thr Glu Leu Leu Val Gly Thr Leu Thr Leu 
        35                  40                  45              


Gly Gly Tyr Lys Thr Gly Thr Thr Ser Thr Ser Val Asn Phe Thr Asp 
    50                  55                  60                  


Ala Ala Gly Asp Pro Met Tyr Leu Thr Phe Thr Ser Gln Asp Gly Asn 
65                  70                  75                  80  


Asn His Gln Phe Thr Thr Lys Val Ile Gly Lys Asp Ser Arg Asp Phe 
                85                  90                  95      


Asp Ile Ser Pro Lys Val Asn Gly Glu Asn Leu Val Gly Asp Asp Val 
            100                 105                 110         


Val Leu Ala Thr Gly Ser Gln Asp Phe Phe Val Arg Ser Ile Gly Ser 
        115                 120                 125             


Lys Gly Gly Lys Leu Ala Ala Gly Lys Tyr Thr Asp Ala Val Thr Val 
    130                 135                 140                 


Thr Val Ser Asn Gln 
145                 


<210>  13
<211>  777
<212>  DNA
<213>  Yersinia pestis

<400>  13
atgattttaa atagattaag tacgttagga attattactt tcggcatgct tagttttgct     60

gcgaactctg ctcaaccaga tatcaaattc gcaagcaaag agtatggcgt gactataggt    120

gagagtagga tcatataccc gttagatgct gctggcgtta tggtctcggt gaaaaacacc    180

caagattatc cggttctcat tcagtctagg atctacgacg agaataaaga aaaagaatca    240

gaggatcctt tcgtggtcac tccgccattg tttcgattgg atgctaagca acaaaattct    300

ttgcgtatag ctcaggctgg aggtgttttc ccgcgagata aagagagcct aaagtggtta    360

tgcgtaaaag ggattccacc aaaggatgaa gatatatggg ttgatgatgc gacaaataag    420

caaaaattca atccagacaa agatgtggga gtgttcgtgc aattcgcaat taataattgc    480

attaagcttt tggttcgacc gaatgaatta aaaggaaccc ctatacagtt tgctgaaaac    540

ttaagctgga aagttgatgg ggggaagcta attgctgaaa acccctcacc tttctacatg    600

aacataggtg aattaacatt tggagggaaa agtattcctt ctcactatat tccacctaaa    660

tcgacgtggg cttttgattt gccaaaagga ctagcgggag cacgtaatgt ttcgtggaga    720

ataattaatg atcagggagg gttggatcgt ttgtattcca aaaatgtgac tttatga       777


<210>  14
<211>  258
<212>  PRT
<213>  Yersinia pestis

<400>  14

Met Ile Leu Asn Arg Leu Ser Thr Leu Gly Ile Ile Thr Phe Gly Met 
1               5                   10                  15      


Leu Ser Phe Ala Ala Asn Ser Ala Gln Pro Asp Ile Lys Phe Ala Ser 
            20                  25                  30          


Lys Glu Tyr Gly Val Thr Ile Gly Glu Ser Arg Ile Ile Tyr Pro Leu 
        35                  40                  45              


Asp Ala Ala Gly Val Met Val Ser Val Lys Asn Thr Gln Asp Tyr Pro 
    50                  55                  60                  


Val Leu Ile Gln Ser Arg Ile Tyr Asp Glu Asn Lys Glu Lys Glu Ser 
65                  70                  75                  80  


Glu Asp Pro Phe Val Val Thr Pro Pro Leu Phe Arg Leu Asp Ala Lys 
                85                  90                  95      


Gln Gln Asn Ser Leu Arg Ile Ala Gln Ala Gly Gly Val Phe Pro Arg 
            100                 105                 110         


Asp Lys Glu Ser Leu Lys Trp Leu Cys Val Lys Gly Ile Pro Pro Lys 
        115                 120                 125             


Asp Glu Asp Ile Trp Val Asp Asp Ala Thr Asn Lys Gln Lys Phe Asn 
    130                 135                 140                 


Pro Asp Lys Asp Val Gly Val Phe Val Gln Phe Ala Ile Asn Asn Cys 
145                 150                 155                 160 


Ile Lys Leu Leu Val Arg Pro Asn Glu Leu Lys Gly Thr Pro Ile Gln 
                165                 170                 175     


Phe Ala Glu Lys Leu Ser Trp Lys Val Asp Gly Gly Lys Leu Ile Ala 
            180                 185                 190         


Glu Asn Pro Ser Pro Phe Tyr Met Asn Ile Gly Glu Leu Thr Phe Gly 
        195                 200                 205             


Gly Lys Ser Ile Pro Ser His Tyr Ile Pro Pro Lys Ser Thr Trp Ala 
    210                 215                 220                 


Phe Asp Leu Pro Lys Gly Leu Ala Gly Ala Arg Asn Val Ser Trp Arg 
225                 230                 235                 240 


Ile Ile Asn Asp Gln Gly Gly Leu Asp Arg Leu Tyr Ser Lys Asn Val 
                245                 250                 255     


Thr Leu 
        


<210>  15
<211>  2502
<212>  DNA
<213>  Yersinia pestis

<400>  15
atgaggtatt caaagctgtt cctgtgtgca gggttaactt tggcaacatt gccttgttgg     60

ggacgcgcat atacttttga ctctactatg cttgatacga atagtggaga gagtatagat    120

gtatctcttt ttaatcaagg acttcaactt ccaggtaatt attttgttaa tgtttttgta    180

aatggtcgaa aggtagactc tggaaatatc gacttccgtc tagaaaaaca taatggaaaa    240

gaacttcttt ggccatgcct atcatcctta caattgacaa agtatggcat tgatatagat    300

aaatatcctg atttaataaa atctggtaca gagcaatgtg ttgatttatt agcaatacca    360

cattcagatg tgcagtttta ttttaatcag cagaaattat cgttaattgt gccaccacag    420

gcacttttac ctagatttga tggcattatg ccaatgcaat tgtgggatga cggcattcct    480

gctctgttca tgaattataa tacgaacatg cagacaagaa aattcagaga aggaggcaag    540

tctctggact cttattatgc tcagttgcaa ccgggattaa acataggggc ttggcgcttt    600

cgtagttcaa cctcatggtg gaaacaacaa ggatggcagc gttcgtatat ttatgccgag    660

cgaggattga atacaattaa gagccgtttg acattggggg aaacctattc tgatagcagt    720

atctttgaca gtatcccgat taaggggata aaaattgctt cagatgaatc gatggttcct    780

tattaccaat ggaattttgc tccagttgtt cgcggtatcg cacgtacaca agccagggta    840

gaggttttaa gagatggcta cactgtaagt aatgagttgg tgccctcggg accatttgag    900

ttagcaaatc ttcctctggg tggggggagt ggtgagctga aagtcatcat tcatgaaagt    960

gatggaacaa agcaagtttt tacagttcca tatgacacac cagcagtggc attacggaag   1020

ggctatttcg aatattcaat gatgggggga gaatatcgtc cagctaatga tcttacacaa   1080

acatcgtatg ttggcgctct tgggatgaaa tatggtttgc caaggaatct tacgttatat   1140

ggtggactac aagggtccca aaattatcat gccgcagctc tgggtatcgg tgctatgttg   1200

ggtgattttg gtgccatatc tacagatgtt actcaagcag acagccagaa aaataaacaa   1260

aaaaaagaaa gcggccaacg ttggcgcgtt cgatataata agtacttgca gagtggaaca   1320

tcgttaaaca ttgctagcga ggaatacgcc acagaaggat ttaacaaact cgctgacacg   1380

ttaaatactt attgtaaacc taatactaga aacgattgcc gttttgatta tgctaaaccc   1440

aaaaacaaag tgcaattcaa tttaagtcaa agcatacctg gttcggggac gcttaatttc   1500

agtggctaca gaaaaaacta ttggcgtgac agtaggagca caacttcttt ttctgtaggc   1560

tataaccatt tttttaggaa tggtatgtca ttgactttaa atttatcgaa gacacagaat   1620

atcaataagt atggagaaaa aactagtgag ctattatcta atatctggtt gagttttcct   1680

ctcagtcgct ggctaggtaa taactcaata aattcaaatt accaaatgac atcagattct   1740

catggtaaca ctacccatga ggtaggtgtg tacggtgaag cctttgatcg ccaattatac   1800

tgggacgttc gcgaacgttt taatgaaaag ggcagaaaat atacctccaa tgcactgaat   1860

ttgaattatc gaggaactta tggggagatc agtggtaact acagctacga tcaaacccaa   1920

agccaacttg gtataggtgt aaatggcaat atggtaataa ctcagtacgg tataacggct   1980

ggccaaaaaa ctggagatac tattgcatta gtacaagccc ctgatataag cggtgcttca   2040

gtgggatact ggccaggcat gaaaacagac tttagggggt acaccaatta tggttactta   2100

accccttaca gagagaataa ggtagaaatt aacccagtta ctttacccaa tgatgcagag   2160

ataacaaata atattgttag cgtgatcccg acaaagggag ctgtagtatt agcaaaattt   2220

aacgcaagga ttggtggacg attgttttta catttaaaac gctctgacaa taaacctgtt   2280

ccatttggtt ctatagttac cattgaaggg caatcatcca gctctggcat tgtcggagat   2340

aatagcggtg tctatttgac tggactacct aaaaaatcaa aaatacttgt taagtggggg   2400

agagataaaa atcaatcatg ttcatctaat gtagttctac cagaaaaaac ggatatttct   2460

ggtgcttata ggttatccac aacctgcatc ttaaataact ga                      2502


<210>  16
<211>  833
<212>  PRT
<213>  Yersinia pestis

<400>  16

Met Arg Tyr Ser Lys Leu Phe Leu Cys Ala Gly Leu Thr Leu Ala Thr 
1               5                   10                  15      


Leu Pro Cys Trp Gly Arg Ala Tyr Thr Phe Asp Ser Thr Met Leu Asp 
            20                  25                  30          


Thr Asn Ser Gly Glu Ser Ile Asp Val Ser Leu Phe Asn Gln Gly Leu 
        35                  40                  45              


Gln Leu Pro Gly Asn Tyr Phe Val Asn Val Phe Val Asn Gly Arg Lys 
    50                  55                  60                  


Val Asp Ser Gly Asn Ile Asp Phe Arg Leu Glu Lys His Asn Gly Lys 
65                  70                  75                  80  


Glu Leu Leu Trp Pro Cys Leu Ser Ser Leu Gln Leu Thr Lys Tyr Gly 
                85                  90                  95      


Ile Asp Ile Asp Lys Tyr Pro Asp Leu Ile Lys Ser Gly Thr Glu Gln 
            100                 105                 110         


Cys Val Asp Leu Leu Ala Ile Pro His Ser Asp Val Gln Phe Tyr Phe 
        115                 120                 125             


Asn Gln Gln Lys Leu Ser Leu Ile Val Pro Pro Gln Ala Leu Leu Pro 
    130                 135                 140                 


Arg Phe Asp Gly Ile Met Pro Met Gln Leu Trp Asp Asp Gly Ile Pro 
145                 150                 155                 160 


Ala Leu Phe Met Asn Tyr Asn Thr Asn Met Gln Thr Arg Lys Phe Arg 
                165                 170                 175     


Glu Gly Gly Lys Ser Leu Asp Ser Tyr Tyr Ala Gln Leu Gln Pro Gly 
            180                 185                 190         


Leu Asn Ile Gly Ala Trp Arg Phe Arg Ser Ser Thr Ser Trp Trp Lys 
        195                 200                 205             


Gln Gln Gly Trp Gln Arg Ser Tyr Ile Tyr Ala Glu Arg Gly Leu Asn 
    210                 215                 220                 


Thr Ile Lys Ser Arg Leu Thr Leu Gly Glu Thr Tyr Ser Asp Ser Ser 
225                 230                 235                 240 


Ile Phe Asp Ser Ile Pro Ile Lys Gly Ile Lys Ile Ala Ser Asp Glu 
                245                 250                 255     


Ser Met Val Pro Tyr Tyr Gln Trp Asn Phe Ala Pro Val Val Arg Gly 
            260                 265                 270         


Ile Ala Arg Thr Gln Ala Arg Val Glu Val Leu Arg Asp Gly Tyr Thr 
        275                 280                 285             


Val Ser Asn Glu Leu Val Pro Ser Gly Pro Phe Glu Leu Ala Asn Leu 
    290                 295                 300                 


Pro Leu Gly Gly Gly Ser Gly Glu Leu Lys Val Ile Ile His Glu Ser 
305                 310                 315                 320 


Asp Gly Thr Lys Gln Val Phe Thr Val Pro Tyr Asp Thr Pro Ala Val 
                325                 330                 335     


Ala Leu Arg Lys Gly Tyr Phe Glu Tyr Ser Met Met Gly Gly Glu Tyr 
            340                 345                 350         


Arg Pro Ala Asn Asp Leu Thr Gln Thr Ser Tyr Val Gly Val Phe Gly 
        355                 360                 365             


Met Lys Tyr Gly Leu Pro Arg Asn Phe Thr Leu Tyr Gly Gly Leu Gln 
    370                 375                 380                 


Gly Ser Gln Asn Tyr His Ala Glu Ala Leu Gly Ile Gly Ala Met Leu 
385                 390                 395                 400 


Gly Asp Phe Gly Ala Ile Ser Thr Asp Val Thr Gln Ala Asp Ser Gln 
                405                 410                 415     


Lys Asn Lys Gln Lys Lys Glu Ser Gly Gln Arg Trp Arg Val Arg Tyr 
            420                 425                 430         


Asn Lys Tyr Leu Gln Ser Gly Thr Ser Leu Asn Ile Ala Ser Glu Glu 
        435                 440                 445             


Tyr Ala Thr Glu Gly Phe Asn Lys Leu Ala Asp Thr Leu Asn Thr Tyr 
    450                 455                 460                 


Cys Lys Pro Asn Thr Arg Asn Asp Cys Arg Phe Asp Tyr Ala Lys Pro 
465                 470                 475                 480 


Lys Asn Lys Val Gln Phe Asn Leu Ser Gln Ser Ile Pro Gly Ser Gly 
                485                 490                 495     


Thr Leu Asn Phe Ser Gly Tyr Arg Lys Asn Tyr Trp Arg Asp Ser Arg 
            500                 505                 510         


Ser Thr Thr Ser Phe Ser Val Gly Tyr Asn His Phe Phe Arg Asn Gly 
        515                 520                 525             


Met Ser Leu Thr Leu Asn Leu Ser Lys Thr Gln Asn Ile Asn Lys Tyr 
    530                 535                 540                 


Gly Glu Lys Thr Ser Glu Leu Leu Ser Asn Ile Trp Leu Ser Phe Pro 
545                 550                 555                 560 


Leu Ser Arg Trp Leu Gly Asn Asn Ser Ile Asn Ser Asn Tyr Gln Met 
                565                 570                 575     


Thr Ser Asp Ser His Gly Asn Thr Thr His Glu Val Gly Val Tyr Gly 
            580                 585                 590         


Glu Ala Phe Asp Arg Gln Leu Tyr Trp Asp Val Arg Glu Arg Phe Asn 
        595                 600                 605             


Glu Lys Gly Arg Lys Tyr Thr Ser Asn Ala Leu Asn Leu Asn Tyr Arg 
    610                 615                 620                 


Gly Thr Tyr Gly Glu Ile Ser Gly Asn Tyr Ser Tyr Asp Gln Thr Gln 
625                 630                 635                 640 


Ser Gln Leu Gly Ile Gly Val Asn Gly Asn Met Val Ile Thr Gln Tyr 
                645                 650                 655     


Gly Ile Thr Ala Gly Gln Lys Thr Gly Asp Thr Ile Ala Leu Val Gln 
            660                 665                 670         


Ala Pro Asp Ile Ser Gly Ala Ser Val Gly Tyr Trp Pro Gly Met Lys 
        675                 680                 685             


Thr Asp Phe Arg Gly Tyr Thr Asn Tyr Gly Tyr Leu Thr Pro Tyr Arg 
    690                 695                 700                 


Glu Tyr Lys Val Glu Ile Asn Pro Val Thr Leu Pro Asn Asp Ala Glu 
705                 710                 715                 720 


Ile Thr Asn Asn Ile Val Ser Val Ile Pro Thr Lys Gly Ala Val Val 
                725                 730                 735     


Leu Ala Lys Phe Asn Ala Arg Ile Gly Gly Arg Leu Phe Leu His Leu 
            740                 745                 750         


Lys Arg Ser Asp Asn Lys Pro Val Pro Phe Gly Ser Ile Val Thr Ile 
        755                 760                 765             


Glu Gly Gln Ser Ser Ser Ser Gly Ile Val Gly Asp Asn Ser Gly Val 
    770                 775                 780                 


Tyr Leu Thr Gly Leu Pro Lys Lys Ser Lys Ile Leu Val Lys Trp Gly 
785                 790                 795                 800 


Arg Asp Lys Asn Gln Ser Cys Ser Ser Asn Val Val Leu Pro Glu Lys 
                805                 810                 815     


Thr Asp Ile Ser Gly Ala Tyr Arg Leu Ser Thr Thr Cys Ile Leu Asn 
            820                 825                 830         


Asn 
    


<210>  17
<211>  906
<212>  DNA
<213>  Yersinia pestis

<400>  17
atgctaaaac agatgactgt aaattcaatt attcaatata tagaagagaa tctcgagtcg     60

aaattcatta acattgactg tttggttttg tattcaggat tcagcagaag gtatttgcaa    120

atttccttta aggaatatgt cggaatgcct attggaacat atattagagt tagaagggct    180

agtagagctg ctgcactatt acggcttacc aggctgacaa taatagagat atcagcaaag    240

cttttttatg attcgcaaca gacattcacc agagaattta agaaaatatt tggttatacc    300

ccacggcagt ataggatgat ccctttttgg tcctttaaag gtttgttggg tagaagggaa    360

attaactgtg aataccttca accacgaatc tgttacctta aagagagaaa tataattggt    420

caatgcttta attttaggga tttagtgttc tactctggga tagattcaaa atgtagattg    480

ggtaagttat atgattcgtt gaagaaaaat acagctataa cagtatcaaa cagaatcccc    540

tttcatgata aaacgaatga cattattgca agaacggttg tttgggatag gaataagcat    600

ttcagcgata gtgaaataaa ggtagataaa ggcctgtatg cttatttttt cttcaatgat    660

acatatgatc agtatgttca tcacatgtac aacatatatt ataactcttt gcctatttat    720

aatttaaata agcgggatgg ttacgatgtg gaggtcataa aaagacgaaa tgacaatact    780

attgattgtc attattttct cccgatttat tgtgatgaca tggagtttta caatgaaatg    840

caggtatatc acaataatat tgtgaagccg gaaatgtcag taacattagg attaccaaag    900

agttaa                                                               906


<210>  18
<211>  301
<212>  PRT
<213>  Yersinia pestis

<400>  18

Met Leu Lys Gln Met Thr Val Asn Ser Ile Ile Gln Tyr Ile Glu Glu 
1               5                   10                  15      


Asn Leu Glu Ser Lys Phe Ile Asn Ile Asp Cys Leu Val Leu Tyr Ser 
            20                  25                  30          


Gly Phe Ser Arg Arg Tyr Leu Gln Ile Ser Phe Lys Glu Tyr Val Gly 
        35                  40                  45              


Met Pro Ile Gly Thr Tyr Ile Arg Val Arg Arg Ala Ser Arg Ala Ala 
    50                  55                  60                  


Ala Leu Leu Arg Leu Thr Arg Leu Thr Ile Ile Glu Ile Ser Ala Lys 
65                  70                  75                  80  


Leu Phe Tyr Asp Ser Gln Gln Thr Phe Thr Arg Glu Phe Lys Lys Ile 
                85                  90                  95      


Phe Gly Tyr Thr Pro Arg Gln Tyr Arg Met Ile Pro Phe Trp Ser Phe 
            100                 105                 110         


Lys Gly Leu Leu Gly Arg Arg Glu Ile Asn Cys Glu Tyr Leu Gln Pro 
        115                 120                 125             


Arg Ile Cys Tyr Leu Lys Glu Arg Asn Ile Ile Gly Gln Cys Phe Asn 
    130                 135                 140                 


Phe Arg Asp Leu Val Phe Tyr Ser Gly Ile Asp Ser Lys Cys Arg Leu 
145                 150                 155                 160 


Gly Lys Leu Tyr Asp Ser Leu Lys Lys Asn Thr Ala Ile Thr Val Ser 
                165                 170                 175     


Asn Arg Ile Pro Phe His Asp Lys Thr Asn Asp Ile Ile Ala Arg Thr 
            180                 185                 190         


Val Val Trp Asp Arg Asn Lys His Phe Ser Asp Ser Glu Ile Lys Val 
        195                 200                 205             


Asp Lys Gly Leu Tyr Ala Tyr Phe Phe Phe Asn Asp Thr Tyr Asp Gln 
    210                 215                 220                 


Tyr Val His His Met Tyr Asn Ile Tyr Tyr Asn Ser Leu Pro Ile Tyr 
225                 230                 235                 240 


Asn Leu Asn Lys Arg Asp Gly Tyr Asp Val Glu Val Ile Lys Arg Arg 
                245                 250                 255     


Asn Asp Asn Thr Ile Asp Cys His Tyr Phe Leu Pro Ile Tyr Cys Asp 
            260                 265                 270         


Asp Met Glu Phe Tyr Asn Glu Met Gln Val Tyr His Asn Asn Ile Val 
        275                 280                 285             


Lys Pro Glu Met Ser Val Thr Leu Gly Leu Pro Lys Ser 
    290                 295                 300     


