                         SEQUENCE LISTING

<110>  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 
       (INSERM)
       UNIVERSIT DE NANTES
 
<120>  Method for evaluating a cancer patient for propensity to respond 
       to a therapy

<130>  BET 13P1850

<150>  EP 12305983.4
<151>  2012-08-08

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  4072
<212>  DNA
<213>  Homo sapiens

<400>  1
acaccgccct cccgccagac tcccggcggc tcctcctccc tctcccaaac ccactcccaa       60

agctaagtgc aggcttcccc gttccagcca gaagcgctgc gtgagcctcc acacgtagcc      120

gcaggcagct ccttaaatag cgtccgcgct gagcaaacag tccagacgtg gggcccagga      180

gggcgagctg aggcgaccgc accgggcgcg cagcggcggc gggtcagccg gcggccaata      240

gccagggcgc ggcccgcccc gtcgcctccc ctcggggagc ctataaggcc tccgcagcgc      300

cccgggcgcc tgctgctccg tgcctccacc gacgacctca ctcagctgcg ttacgcgccg      360

ctccggctgc cggccgcgcg ccttgcccgc cggctcccgc ccgcaatcgg cggctcaggg      420

cggacccggg tctctgcgtt ctcgcgagaa gcgcggcgct gcggggccgt gggcgcctga      480

gcccgcgcgg ccctcgaggg ccgaatatgg ggggatgcac ggtgaagcct cagctgctgc      540

tcctggcgct cgtcctccac ccctggaatc cctgtctggg tgcggactcg gagaagccct      600

cgagcatccc cacagataaa ttattagtca taactgtagc aacaaaagaa agtgatggat      660

tccatcgatt tatgcagtca gccaaatatt tcaattatac tgtgaaggtc cttggtcaag      720

gagaagaatg gagaggtggt gatggaatta atagtattgg agggggccag aaagtgagat      780

taatgaaaga agtcatggaa cactatgctg atcaagatga tctggttgtc atgtttactg      840

aatgctttga tgtcatattt gctggtggtc cagaagaagt tctaaaaaaa ttccaaaagg      900

caaaccacaa agtggtcttt gcagcagatg gaattttgtg gccagataaa agactagcag      960

acaagtatcc tgttgtgcac attgggaaac gctatctgaa ttcaggagga tttattggct     1020

atgctccata tgtcaaccgt atagttcaac aatggaatct ccaggataat gatgatgatc     1080

agctctttta cactaaagtt tacattgatc cactgaaaag ggaagctatt aacatcacat     1140

tggatcacaa atgcaaaatt ttccagacct taaatggagc tgtagatgaa gttgttttaa     1200

aatttgaaaa tggcaaagcc agagctaaga atacatttta tgaaacatta ccagtggcaa     1260

ttaatggaaa tggacccacc aagattctcc tgaattattt tggaaactat gtacccaatt     1320

catggacaca ggataatggc tgcactcttt gtgaattcga tacagtcgac ttgtctgcag     1380

tagatgtcca tccaaacgta tcaataggtg tttttattga gcaaccaacc ccttttctac     1440

ctcggtttct ggacatattg ttgacactgg attacccaaa agaagcactt aaacttttta     1500

ttcataacaa agaagtttat catgaaaagg acatcaaggt attttttgat aaagctaagc     1560

atgaaatcaa aactataaaa atagtaggac cagaagaaaa tctaagtcaa gcggaagcca     1620

gaaacatggg aatggacttt tgccgtcagg atgaaaagtg tgattattac tttagtgtgg     1680

atgcagatgt tgttttgaca aatccaagga ctttaaaaat tttgattgaa caaaacagaa     1740

agatcattgc tcctcttgta actcgtcatg gaaagctgtg gtccaatttc tggggagcat     1800

tgagtcctga tggatactat gcacgatctg aagattatgt ggatattgtt caagggaata     1860

gagtaggagt atggaatgtc ccatatatgg ctaatgtgta cttaattaaa ggaaagacac     1920

tccgatcaga gatgaatgaa aggaactatt ttgttcgtga taaactggat cctgatatgg     1980

ctctttgccg aaatgctaga gaaatgactt tacaaaggga aaaagactcc cctactccgg     2040

aaacattcca aatgctcagc cccccaaagg gtgtatttat gtacatttct aatagacatg     2100

aatttggaag gctattatcc actgctaatt acaatacttc ccattataac aatgacctct     2160

ggcagatttt tgaaaatcct gtggactgga aggaaaagta tataaaccgt gattattcaa     2220

agattttcac tgaaaatata gttgaacagc cctgtccaga tgtcttttgg ttccccatat     2280

tttctgaaaa agcctgtgat gaattggtag aagaaatgga acattacggc aaatggtctg     2340

ggggaaaaca tcatgatagc cgtatatctg gtggttatga aaatgtccca actgatgata     2400

tccacatgaa gcaagttgat ctggagaatg tatggcttca ttttatccgg gagttcattg     2460

caccagttac actgaaggtc tttgcaggct attatacgaa gggatttgca ctactgaatt     2520

ttgtagtaaa atactcccct gaacgacagc gttctcttcg tcctcatcat gatgcttcta     2580

catttaccat aaacattgca cttaataacg tgggagaaga ctttcaggga ggtggttgca     2640

aatttctaag gtacaattgc tctattgagt caccacgaaa aggctggagc ttcatgcatc     2700

ctgggagact cacacatttg catgaaggac ttcctgttaa aaatggaaca agatacattg     2760

cagtgtcatt tatagatccc taagttattt acttttcatt gaattgaaat ttattttgga     2820

tgaatgactg gcatgaacac gtctttgaag ttgtggctga gaagatgaga ggaatattta     2880

aataacatca acagaacaac ttcactttgg gccaaacatt tgaaaaactt tttataaaaa     2940

attgtttgat atttcttaat gtctgctctg agccttaaaa cacagattga agaagaaaag     3000

aaagaaaaaa cttaaatatt tatttctatg ctttgttgcc tctgagaata atgacaattt     3060

atgaatttgt gtttcaaatt gataaaatat ttaggtacaa ataacaagac taataatatt     3120

ttcttattta aaaaaagcat gggaagattt ttatttatca aaatatagag gaaatgtaga     3180

caaaatggat ataaatgaaa attaccatgt tgtaaaacct tgaaaatcag attctaactg     3240

gatttgtatg caactaagta tttttctgaa cacctatgca ggtcttattt acagtagtta     3300

ctaagggaac acacaaagaa ttacacaacg ttttcctcaa gaaaatggta caaaacacaa     3360

ccgaggagcg tatacagttg aaaacatttt tgttttgatt ggaaggcaga ttattttata     3420

ttagtattaa aaatcaaacc ctatgtttct ttcagatgaa tcttccaaag tggattatat     3480

taagcaggta ttagatttag gaaaaccttt ccatttctta aagtattatc aagtgtcaag     3540

atcagcaagt gtccttaagt caaacaggtt ttttttgttg ttgtttttgc tttgtttcct     3600

tttttagaaa gttctagaaa ataggaaaac gaaaaatttc attgagatga gtagtgcatt     3660

taattatttt ttaaaaaact ttttaagtac ttgaatttta tatcaggaaa acaaagttgt     3720

tgagccttgc ttcttccgtt ttgccctttg tctcgctcct tattcttttt ttggggggag     3780

ggttatttgc ttttttatct tcctggcata atttccattt tattcttctg agtgtctatg     3840

ttaacttccc tctatcccgc ttataaaaaa attctccaac aaaaatactt gttgacttga     3900

tgttttatca cttctctaag taaggttgaa atatccttat tgtagctact gtttttaatg     3960

taaaggttaa acttgaaaag aaattcttaa tcacggtgcc aaaattcatt ttctaacacc     4020

atgtgttaga aaattataaa aaataaaata attttagaaa aaaaaaaaaa aa             4072


<210>  2
<211>  758
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Gly Cys Thr Val Lys Pro Gln Leu Leu Leu Leu Ala Leu Val 
1               5                   10                  15      


Leu His Pro Trp Asn Pro Cys Leu Gly Ala Asp Ser Glu Lys Pro Ser 
            20                  25                  30          


Ser Ile Pro Thr Asp Lys Leu Leu Val Ile Thr Val Ala Thr Lys Glu 
        35                  40                  45              


Ser Asp Gly Phe His Arg Phe Met Gln Ser Ala Lys Tyr Phe Asn Tyr 
    50                  55                  60                  


Thr Val Lys Val Leu Gly Gln Gly Glu Glu Trp Arg Gly Gly Asp Gly 
65                  70                  75                  80  


Ile Asn Ser Ile Gly Gly Gly Gln Lys Val Arg Leu Met Lys Glu Val 
                85                  90                  95      


Met Glu His Tyr Ala Asp Gln Asp Asp Leu Val Val Met Phe Thr Glu 
            100                 105                 110         


Cys Phe Asp Val Ile Phe Ala Gly Gly Pro Glu Glu Val Leu Lys Lys 
        115                 120                 125             


Phe Gln Lys Ala Asn His Lys Val Val Phe Ala Ala Asp Gly Ile Leu 
    130                 135                 140                 


Trp Pro Asp Lys Arg Leu Ala Asp Lys Tyr Pro Val Val His Ile Gly 
145                 150                 155                 160 


Lys Arg Tyr Leu Asn Ser Gly Gly Phe Ile Gly Tyr Ala Pro Tyr Val 
                165                 170                 175     


Asn Arg Ile Val Gln Gln Trp Asn Leu Gln Asp Asn Asp Asp Asp Gln 
            180                 185                 190         


Leu Phe Tyr Thr Lys Val Tyr Ile Asp Pro Leu Lys Arg Glu Ala Ile 
        195                 200                 205             


Asn Ile Thr Leu Asp His Lys Cys Lys Ile Phe Gln Thr Leu Asn Gly 
    210                 215                 220                 


Ala Val Asp Glu Val Val Leu Lys Phe Glu Asn Gly Lys Ala Arg Ala 
225                 230                 235                 240 


Lys Asn Thr Phe Tyr Glu Thr Leu Pro Val Ala Ile Asn Gly Asn Gly 
                245                 250                 255     


Pro Thr Lys Ile Leu Leu Asn Tyr Phe Gly Asn Tyr Val Pro Asn Ser 
            260                 265                 270         


Trp Thr Gln Asp Asn Gly Cys Thr Leu Cys Glu Phe Asp Thr Val Asp 
        275                 280                 285             


Leu Ser Ala Val Asp Val His Pro Asn Val Ser Ile Gly Val Phe Ile 
    290                 295                 300                 


Glu Gln Pro Thr Pro Phe Leu Pro Arg Phe Leu Asp Ile Leu Leu Thr 
305                 310                 315                 320 


Leu Asp Tyr Pro Lys Glu Ala Leu Lys Leu Phe Ile His Asn Lys Glu 
                325                 330                 335     


Val Tyr His Glu Lys Asp Ile Lys Val Phe Phe Asp Lys Ala Lys His 
            340                 345                 350         


Glu Ile Lys Thr Ile Lys Ile Val Gly Pro Glu Glu Asn Leu Ser Gln 
        355                 360                 365             


Ala Glu Ala Arg Asn Met Gly Met Asp Phe Cys Arg Gln Asp Glu Lys 
    370                 375                 380                 


Cys Asp Tyr Tyr Phe Ser Val Asp Ala Asp Val Val Leu Thr Asn Pro 
385                 390                 395                 400 


Arg Thr Leu Lys Ile Leu Ile Glu Gln Asn Arg Lys Ile Ile Ala Pro 
                405                 410                 415     


Leu Val Thr Arg His Gly Lys Leu Trp Ser Asn Phe Trp Gly Ala Leu 
            420                 425                 430         


Ser Pro Asp Gly Tyr Tyr Ala Arg Ser Glu Asp Tyr Val Asp Ile Val 
        435                 440                 445             


Gln Gly Asn Arg Val Gly Val Trp Asn Val Pro Tyr Met Ala Asn Val 
    450                 455                 460                 


Tyr Leu Ile Lys Gly Lys Thr Leu Arg Ser Glu Met Asn Glu Arg Asn 
465                 470                 475                 480 


Tyr Phe Val Arg Asp Lys Leu Asp Pro Asp Met Ala Leu Cys Arg Asn 
                485                 490                 495     


Ala Arg Glu Met Thr Leu Gln Arg Glu Lys Asp Ser Pro Thr Pro Glu 
            500                 505                 510         


Thr Phe Gln Met Leu Ser Pro Pro Lys Gly Val Phe Met Tyr Ile Ser 
        515                 520                 525             


Asn Arg His Glu Phe Gly Arg Leu Leu Ser Thr Ala Asn Tyr Asn Thr 
    530                 535                 540                 


Ser His Tyr Asn Asn Asp Leu Trp Gln Ile Phe Glu Asn Pro Val Asp 
545                 550                 555                 560 


Trp Lys Glu Lys Tyr Ile Asn Arg Asp Tyr Ser Lys Ile Phe Thr Glu 
                565                 570                 575     


Asn Ile Val Glu Gln Pro Cys Pro Asp Val Phe Trp Phe Pro Ile Phe 
            580                 585                 590         


Ser Glu Lys Ala Cys Asp Glu Leu Val Glu Glu Met Glu His Tyr Gly 
        595                 600                 605             


Lys Trp Ser Gly Gly Lys His His Asp Ser Arg Ile Ser Gly Gly Tyr 
    610                 615                 620                 


Glu Asn Val Pro Thr Asp Asp Ile His Met Lys Gln Val Asp Leu Glu 
625                 630                 635                 640 


Asn Val Trp Leu His Phe Ile Arg Glu Phe Ile Ala Pro Val Thr Leu 
                645                 650                 655     


Lys Val Phe Ala Gly Tyr Tyr Thr Lys Gly Phe Ala Leu Leu Asn Phe 
            660                 665                 670         


Val Val Lys Tyr Ser Pro Glu Arg Gln Arg Ser Leu Arg Pro His His 
        675                 680                 685             


Asp Ala Ser Thr Phe Thr Ile Asn Ile Ala Leu Asn Asn Val Gly Glu 
    690                 695                 700                 


Asp Phe Gln Gly Gly Gly Cys Lys Phe Leu Arg Tyr Asn Cys Ser Ile 
705                 710                 715                 720 


Glu Ser Pro Arg Lys Gly Trp Ser Phe Met His Pro Gly Arg Leu Thr 
                725                 730                 735     


His Leu His Glu Gly Leu Pro Val Lys Asn Gly Thr Arg Tyr Ile Ala 
            740                 745                 750         


Val Ser Phe Ile Asp Pro 
        755             


<210>  3
<211>  2265
<212>  DNA
<213>  Homo sapiens

<400>  3
ggggcaacca ggggaagatg gggtgctgga ggagagcttg tgggagccaa ggagcacctt       60

ggacatctgg agtctggcag gagtgatgac gggtggaggg gctagctcga ggcagggctg      120

gtggggcctg aggccagtga ggagtgtgga gtaggcgccc aggcatcgtg cagacagggc      180

gacatcagct ggggacgatg ggcctgagct agggctggaa agaaggggga gccaggcatt      240

catcccggtc acttttggtt acaggacgtg gcagctggtt ggacgagggg agctggtggg      300

cagggtttga tcccagggcc tgggcaacgg aggtgtagct ggcagcagcg ggcaggtgag      360

gaccccatct gccgggcagg tgagtccctt ccctccccag gcctcgcttc cccagccttc      420

tgaaagaagg aggtttaggg gatcgagggc tggcggggag aagcagacac cctcccagca      480

gaggggcagg atgggggcag gagagttagc aaaggtgaca tcttctcggg gggagccgag      540

actgcgcaag gctggggggt tatgggcccg ttccaggcag aaagagcaag agggcaggga      600

gggagcacag gggtggccag cgtagggtcc agcacgtggg gtggtacccc aggcctgggt      660

cagacaggga catggcaggg gacacaggac agaggggtcc ccagctgcca cctcacccac      720

cgcaattcat ttagtagcag gcacaggggc agctccggca cggctttctc aggcctatgc      780

cggagcctcg agggctggag agcgggaaga caggcagtgc tcggggagtt gcagcaggac      840

gtcaccagga gggcgaagcg gccacgggag gggggccccg ggacattgcg cagcaaggag      900

gctgcagggg ctcggcctgc gggcgccggt cccacgaggc actgcggccc agggtctggt      960

gcggagaggg cccacagtgg acttggtgac gctgtatgcc ctcaccgctc agcccctggg     1020

gctggcttgg cagacagtac agcatccagg ggagtcaagg gcatggggcg agaccagact     1080

aggcgaggcg ggcggggcgg agtgaatgag ctctcaggag ggaggatggt gcaggcaggg     1140

gtgaggagcg cagcgggcgg cgagcgggag gcactggcct ccagagcccg tggccaaggc     1200

gggcctcgcg ggcggcgacg gagccgggat cggtgcctca gcgttcgggc tggagacgag     1260

gccaggtctc cagctggggt ggacgtgccc accagctgcc gaaggccaag acgccaggtc     1320

cggtggacgt gacaagcagg acatgacatg gtccggtgtg acggcgagga cagaggaggc     1380

gcgtccggcc ttcctgaaca ccttaggctg gtggggctgc ggcaagaagc gggtctgttt     1440

ctttacttcc tccacggagt cggcacacta tggctgccct ctgggctccc agaacccaca     1500

acatgaaaga aatggtgcta cccagctcaa gcctgggcct ttgaatccgg acacaaaacc     1560

ctctagcttg gaaatgaata tgctgcactt tacaaccact gcactacctg actcaggaat     1620

cggctctgga aggtgaagct agaggaacca gacctcatca gcccaacatc aaagacacca     1680

tcggaacagc agcgcccgca gcacccaccc cgcaccggcg actccatctt catggccacc     1740

ccctgcggcg gacggttgac caccagccac cacatcatcc cagagctgag ctcctccagc     1800

gggatgacgc cgtccccacc acctccctct tcttcttttt catccttctg tctctttgtt     1860

tctgagcttt cctgtctttc cttttttctg agagattcaa agcctccacg actctgtttc     1920

ccccgtccct tctgaattta atttgcacta agtcatttgc actggttgga gttgtggaga     1980

cggccttgag tctcagtacg agtgtgcgtg agtgtgagcc accttggcaa gtgcctgtgc     2040

agggcccggc cgccctccat ctgggccggg tgactgggcg ccggctgtgt gcccgaggcc     2100

tcaccctgcc ctcgcctagt ctggaagctc cgaccgacat cacggagcag ccttcaagca     2160

ttccattacg ccccatctcg ctctgtgccc ctccccacca gggcttcagc aggagccctg     2220

gactcatcat caataaacac tgttacagca aaaaaaaaaa aaaaa                     2265


<210>  4
<211>  2687
<212>  DNA
<213>  Homo sapiens

<400>  4
cggaggcagc aaggccttaa aggctactga gtgcgccggc cgttccgtgt ccagaacctc       60

ccctactcct ccgccttctc ttccttggcc gcccaccgcc aagttccgac tccggttttc      120

gcctttgcaa agcctaagga ggaggttagg aacagccgcg cccccctccc tgcggccgcc      180

gccccctgcc tctcggctct gctccctgcc gcgtgcgcct gggccgtgcg ccccggcagg      240

ccccagccat gtcgatgctg ccgtcgtttg gctttacgca ggagcaagtg gcgtgcgtgt      300

gcgaggttct gcagcaaggc ggaaacctgg agcgcctggg caggttcctg tggtcactgc      360

ccgcctgcga ccacctgcac aagaacgaga gcgtactcaa ggccaaggcg gtggtcgcct      420

tccaccgcgg caacttccgt gagctctaca agatcctgga gagccaccag ttctcgcctc      480

acaaccaccc caaactgcag caactgtggc tgaaggcgca ttacgtggag gccgagaagc      540

tgcgcggccg acccctgggc gccgtgggca aatatcgggt gcgccgaaaa tttccactgc      600

cgcgcaccat ctgggacggc gaggagacca gctactgctt caaggagaag tcgaggggtg      660

tcctgcggga gtggtacgcg cacaatccct acccatcgcc gcgtgagaag cgggagctgg      720

ccgaggccac cggcctcacc accacccagg tcagcaactg gtttaagaac cggaggcaaa      780

gagaccgggc cgcggaggcc aaggaaaggg agaacaccga aaacaataac tcctcctcca      840

acaagcagaa ccaactctct cctctggaag ggggcaagcc gctcatgtcc agctcagaag      900

aggaattctc acctccccaa agtccagacc agaactcggt ccttctgctg cagggcaata      960

tgggccacgc caggagctca aactattctc tcccgggctt aacagcctcg cagcccagtc     1020

acggcctgca gacccaccag catcagctcc aagactctct gctcggcccc ctcacctcca     1080

gtctggtgga cttggggtcc taagtgggga gggactgggg cctcgaaggg attcctggag     1140

cagcaaccac tgcagcgact agggacactt gtaaatagaa atcaggaaca tttttgcagc     1200

ttgtttctgg agttgtttgc gcataaagga atggtggact ttcacaaata tctttttaaa     1260

aatcaaaacc aacagcgatc tcaagcttaa tctcctcttc tctccaactc tttccacttt     1320

tgcattttcc ttcccaatgc agagatcagg gaaaaaaaaa aaaaaaaacc caaacaaaca     1380

aaagcaccca ggcacccagt ctgagttctg ggcaactgat acgcctgttt cagcagcctt     1440

tctttttttt caatgaatgg gaattgcaaa tcaactggat tttcattatt tccttttaat     1500

ttatatatgg agaaatgtga agagggaaag gaaatggaaa gagaaagaga aagggagata     1560

aaaatagtga aaataagagc ctccaggctc agaagaactg attacattct taaggtgaac     1620

aggaaaaata caatctataa ctttctttga tgaggaaaaa ttaagtttac atttttcata     1680

tttagtgtta aacaatttaa tgtagattaa aataaaagac cagtattagg aggaaaaaac     1740

aagtgcctaa atgtcttaat gctctctatg tgagacagaa atagacgtga ccattagtaa     1800

tgcaactatt tttgtcaaat ttagtgggat tttttggttg ttgtttgttt tcttgggttt     1860

ttttttttta aatgacaaac tctaaaaatg taccaatgtg aaaaaacact ttcctgaatg     1920

ccattactca tgccctcaaa gctttcatat ctgtagccta ctcctgtaaa gggtttctcc     1980

tgtttctagt ttctagtttg caaaggtatg ccaacgaatc tggcaacctg gtatttgtta     2040

ctaaaacagc atgtgttttc aggtttcttt tctattgtac ctaaagcagt ctaaattaaa     2100

acttagtaga acaccaggag tatgattctg tttctgaaag gtgagtggtg tattgctgtc     2160

attgggccct attttttttt ttaaatatat ttttctttct tacttaatgg tggctgtgaa     2220

ttgcagggta ctttgaaggc catcatctga accaagagta gtaactagat taattatatg     2280

acagaaagag tgaatttagc cttggggtat ttattaactt ctattattta gatatgcaat     2340

tttgtttacc actatctctt cacagcattc atatgttaac taagctcttt tgtgttaaca     2400

agtttatgac aagactgtga aagtaaaaat aatttatctg cttgaagaca aaaaagggaa     2460

ggagaacaag gatagaaaca ttgtgaatta atttgtacaa atagaaagca gaccagcagg     2520

acaggagctc ttttgcagtg ctgccggatg gtgtctagaa aaatcccagt aatcatgtag     2580

gctccatatt atttttgcct ggggcaaaat gatgtatctt ctgtatttag cttttaaaat     2640

tagtgaaaca aatggcatta tttattaaaa ttctactcag gataaca                   2687


<210>  5
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Met Leu Pro Ser Phe Gly Phe Thr Gln Glu Gln Val Ala Cys 
1               5                   10                  15      


Val Cys Glu Val Leu Gln Gln Gly Gly Asn Leu Glu Arg Leu Gly Arg 
            20                  25                  30          


Phe Leu Trp Ser Leu Pro Ala Cys Asp His Leu His Lys Asn Glu Ser 
        35                  40                  45              


Val Leu Lys Ala Lys Ala Val Val Ala Phe His Arg Gly Asn Phe Arg 
    50                  55                  60                  


Glu Leu Tyr Lys Ile Leu Glu Ser His Gln Phe Ser Pro His Asn His 
65                  70                  75                  80  


Pro Lys Leu Gln Gln Leu Trp Leu Lys Ala His Tyr Val Glu Ala Glu 
                85                  90                  95      


Lys Leu Arg Gly Arg Pro Leu Gly Ala Val Gly Lys Tyr Arg Val Arg 
            100                 105                 110         


Arg Lys Phe Pro Leu Pro Arg Thr Ile Trp Asp Gly Glu Glu Thr Ser 
        115                 120                 125             


Tyr Cys Phe Lys Glu Lys Ser Arg Gly Val Leu Arg Glu Trp Tyr Ala 
    130                 135                 140                 


His Asn Pro Tyr Pro Ser Pro Arg Glu Lys Arg Glu Leu Ala Glu Ala 
145                 150                 155                 160 


Thr Gly Leu Thr Thr Thr Gln Val Ser Asn Trp Phe Lys Asn Arg Arg 
                165                 170                 175     


Gln Arg Asp Arg Ala Ala Glu Ala Lys Glu Arg Glu Asn Thr Glu Asn 
            180                 185                 190         


Asn Asn Ser Ser Ser Asn Lys Gln Asn Gln Leu Ser Pro Leu Glu Gly 
        195                 200                 205             


Gly Lys Pro Leu Met Ser Ser Ser Glu Glu Glu Phe Ser Pro Pro Gln 
    210                 215                 220                 


Ser Pro Asp Gln Asn Ser Val Leu Leu Leu Gln Gly Asn Met Gly His 
225                 230                 235                 240 


Ala Arg Ser Ser Asn Tyr Ser Leu Pro Gly Leu Thr Ala Ser Gln Pro 
                245                 250                 255     


Ser His Gly Leu Gln Thr His Gln His Gln Leu Gln Asp Ser Leu Leu 
            260                 265                 270         


Gly Pro Leu Thr Ser Ser Leu Val Asp Leu Gly Ser 
        275                 280                 


<210>  6
<211>  6388
<212>  DNA
<213>  Homo sapiens

<400>  6
ctcgcttttc ttgcaatatt ttataccttt tcaattcata gaattactca agaaaactac       60

ctcagttggt tgctactttt tgttgattcc ttttaccaga catgactaag tttctttttc      120

atcagtagat ttctgggctc ctatattcac tagagattgc aactcctgga tttctcttac      180

actagaatcc tatttcgagc catatgggag attctgaatt ccagaacaaa agaattttgt      240

aatttaaaat tcgtgattgc tcaatggaat cattttaatt gttacttcat ttctgtcgtt      300

atttaaaact taagtggaga gttttctcag ggataagaaa accacaatca aggtcataca      360

aaacttttag aggcagtcag tctgctaaga aggctccagc aagagaaacg ggatcttctg      420

tttcaacaat cattacttaa gaaaaaatta agaaaatgaa ataagttttg cagaataact      480

gtgaaatttt tattcatgaa atatgtactt acactttggg ccacgtgatg tcactctttg      540

ccgcgatgtt ctctctgaat ccagacaaat acagcccttt tcccatggga aagaggctca      600

attctttttc actctctctg tgctgaacga tggcgaacac agcagaatgg gactgacgaa      660

atcagatgat ttcttctaat ttggaggcaa ttttcactaa ttagaagaag actgagtatt      720

tgaaatgtta tactcaagtc gaggagatcc agagggtcag cctctactgc tctcgcttct      780

gatcctcgca atgtgggtgg tggggagcgg ccagctccac tactccgtcc cggaggaagc      840

cgaacacggc accttcgtgg gccgcatcgc gcaggacctg gggctggagc tggcggagct      900

ggtgccgcgc ctgttccagt tggattccaa aggccgcggg gaccttctgg aggtaaatct      960

gcagaatggc attttgtttg tgaattctcg gatcgaccgc gaggagctgt gcgggcggag     1020

cgcggagtgc agcatccacc tggaggtgat cgtagacagg ccgctgcagg ttttccatgt     1080

ggacgtggag gtgaaggaca ttaacgacaa ccctccagtg ttcccagcga cacaaaagaa     1140

tctgttcatc gcggaatcca ggccgcttga ctctcggttt ccactagagg gcgcgtccga     1200

tgcagatatc ggggagaacg ccctgctcac ttacagactg agccccaatg agtatttctt     1260

cctggacgtg ccaaccagca accagcaggt aaaacctctt ggacttgtat tacggaaact     1320

tttagacaga gaagaaactc cggagcttca tttattgctc acggccaccg atggaggcaa     1380

acccgagctg actggcaccg ttcaattact catcacggta ctggacaaca atgacaatgc     1440

cccagtgttc gacagaaccc tgtatacggt gaaattacca gaaaacgttt ctatcggaac     1500

gctggtgatt caccccaatg cctcagattt agacgaaggc ttgaatgggg atattattta     1560

ctccttctcc agtgatgttt ctccagatat aaaatccaag ttccacatgg accccttaag     1620

tggggcaatc acagtgatag gacatatgga ttttgaagaa agtagagcac acaagatccc     1680

agtcgaggct gtcgataaag gcttcccacc cctggctggt cattgtacac ttcttgtgga     1740

agttgtggat gtaaatgaca atgctccaca gttgactatc aaaacgctct cggttcctgt     1800

aaaagaggac gcacaactgg ggacagttat tgccctgatt agtgtgatcg acctagacgc     1860

agatgccaac gggcaggtta cctgctccct gacgccccac gtccccttca agctggtgtc     1920

cacctacaag aattactact cgttggtgct ggacagagct ctggaccgcg agagtgtgtc     1980

cgcctacgag ctggtggtta ccgcgcggga cgggggctcg ccttcactgt gggccacggc     2040

cagggtgtct gtggaggtgg ccgacgtgaa cgacaacgca ccagcgttcg cgcagtccga     2100

gtacacggtg ttcgtgaagg agaacaaccc gccgggctgc cacatcttca cggtgtctgc     2160

gcgggacgct gacgcgcagg agaacgccct ggtgtcctac tcgctggtgg agcggcggtt     2220

gggcgagcgc tcgctgtcga gctacgtgtc agtgcacgcg gagagcggca aggtgtacgc     2280

gctgcagccg ttggaccacg aggagctgga gctgctacag ttccaggtga gcgcgcgcga     2340

cgcgggcgtg ccgcctctgg gcagcaacgt gacgctgcag gtgttcgtgc tggacgagaa     2400

cgacaatgcg ccggcgctgc tgacacctcg gatgaggggc actgacggcg cagtgagcga     2460

gatggtgctg cggtcggtgg gcgccggcgt agtggtgggg aaggtgcgcg cagtggacgc     2520

cgactcgggc tacaacgcgt ggctttcata cgagctgcag ccagaaacgg ccagcgcgag     2580

catcccgttc cgcgtggggc tgtacacggg cgagatcagc acaacgcgtg ccctggacga     2640

aacggacgca ccgcgccagc gcctactggt gctggtgaaa gaccacgggg agccagcgct     2700

gacggccacg gccactgtgc tggtgtcgct ggtggagagc ggccaggcgc caaagtcatc     2760

gtcgcgggcg tcagtgggtg ccacgggccc cgaggtgacg ctggtggatg tcaacgtgta     2820

cctgatcatc gccatctgcg cggtgtctag cctgttggtt ctcacgctgc tgctgtacac     2880

tgtgctgcgg tgctcggcga tgcccaccga gggcgagtgc gcgcctggca agccgacgct     2940

ggtgtgttct agcgcggtgg ggagttggtc gtactcgcag cagaggaggc agagggtgtg     3000

ctctggcgag ggtaagcaga agaccgacct catggccttc agcccgggcc tttctccttg     3060

tgctggatct acagagcgaa cgggagaacc ctctgcttcc tcagattcaa ctgggaaggt     3120

gggtttttct agcattttat ttatttatat aatttttttt cttgaaagat attatcgatt     3180

actcccaggg gccgttcaaa tagttttatt catttttcta gaaatccagc agattttttt     3240

tctgataaag taaacccctt aacattggag ccgactttgt cttgacttct agtgagaatt     3300

ataaactgta tattaaatag atattttttg ggtgctgaat caattttatt taaatttgtg     3360

attaaagtga cattgaattt ctgatgctat gctgccataa cacttgaaaa ccaatttagt     3420

tgttagtcat tcattaaaca ttaacatcac tatcatttat ttattgctaa atgatgcata     3480

gtattttagt ctacttgtat tgtttataag aaacccaagc aaaaatatat agcaattgtt     3540

accttgttaa gtttgtagtt ctctacattt ctctggatgg agactgtgaa catctgattg     3600

ttcagcaacc ttcagtatct attattttaa taagaaagaa acttccccta aactttagaa     3660

aacagttgct ccactttagg aatcaaatta tgtcaataaa tgttataaac acagccttca     3720

tttcaactta tataaaatat gttttaaaat gcctgacaat gtagataatt caagaaatgt     3780

tgactgaaat tttgtctaca cttagaacat tttttgaaat tcagtttaca gaaattggag     3840

aaaatgcttt ttaaacaagt gtttcctttc ttcaagaaga tattctcctt ttaattgaaa     3900

ttttctccat tcagtgataa aatgatcagc catgtgaaga ttcgaaactt cgagttcttt     3960

tgaaattcag agtctgtaac ttaaaacatt acccttatga atttagatga gaattcactt     4020

gttctgtcag taatccataa gacagaaatc tgttttttta aaaatatctt tttctcctct     4080

cagctcatac ataacacaag gcagaaatct ggatatgaga tttgcctctt taatgtcact     4140

acatgttatg tttcctgaat tgtagtatgt gactttcaaa atggtggttt tccacactct     4200

acctttagtg caagctattt gtttgttttc taatttatag ttttaaaaac ttcgcttatt     4260

gagtttttgt tatgtggttt atatttttct ttctctttca gctattttat ttaatattgt     4320

gtcagatatt ttacaaggta tgacctaatt aaaaactcag tagagaaaga tcagaatggc     4380

cttgagaata gagccacaaa aataactatg aaaatgccag taacgtttat ttaaaacaaa     4440

atattttaat ttttaaattt tcccttaaaa cacacttttg gaatatgcta caatattaca     4500

tgttttttgt ctttttattt ttctgagacg gagtcgtttt ctgccaccca ggctggagta     4560

cagtggcatg atcttggctc actgcaacgt ctgcctcctg ggttcaagca attctcctgc     4620

ctcagcctcc tgagtagctg ggattatagg cacatgccac cgcgcccagc taatttttgt     4680

atttttagta gagatggggt ttcatcatgt tggccaggtt ggtctcgaac tcctgacctt     4740

gtgatgctcc cacctcggcc tcccaaagtg ctgggattaa agctgtgagc cactgtgcca     4800

aggctttttt attttttttt tttgtcattt tctttcaaaa cttgagtggt ctctgagctc     4860

ctgtcattaa acctatctat atctgtctat cagcacaact caccttgaat atagtcttat     4920

actttcaagt atctttgtct ttgcacgttt ttcaagtttc atgtgccatt taaacttgga     4980

cccaggtatc tgattatttg atgtgaatag agggatgcta cagatgtcat ttgtctcccg     5040

ccctaagtcc tccagtctcc ttagagctag tacttactaa gcatttacta tgtcatcaat     5100

aatcataaaa cgtatttttt tttttgagtc agagtctcgc tctgttgccc aggctggagt     5160

gcagtggtgc catcttggct cactccaagc tccccctccc gtgttcacgc cattctcctg     5220

cctcagcctc ccgagtagct gggactacag gcgcctgcca ccatgcccgc ctaatttttt     5280

tgtattttta gtagagatgg ggtttcaccg tgttagtcag gatggtctcg atctcctgac     5340

ctcatgatcc tcccgcctca gcctcccaaa atgctgggat tacaggcgtg agccaccgcg     5400

cctggcctaa aatgtgttct ttattattga cggctgtatt gatgggattg gtaatttagt     5460

ccttcatatt aatctctatt ctctctcaga gtacaagctc tcatcatatg caaattctca     5520

gaagggctgt gaacacctta gtaataaatt tatcttttga ggtcattagc aaacatgaac     5580

tcacagggat ccagagatgg taaaattcaa aacagcctgt caagttcaaa acagagaggt     5640

gaaagcagaa gagacacttt cctattttgc ctaataggtc tccttatatg catctgtagt     5700

taacattcct caattcaagt tagaatcatg aaacaataat gaagctcctc ctatgtctct     5760

tttcaagttg taattactat ataggaaaaa ctaagttgtc acccaatatc ttagacactt     5820

tgagagcaaa gggggtgctg taaataagta tacaagatca cagacctaaa ttgagcctgt     5880

tccagacaaa ttggggccta tggtcaacct atccttagac ctgctaacgc attagcatta     5940

gcagcaccta agtcctcatt gaatgttctg gttcaaggct ccacctcaga aattctgaaa     6000

tgggtagtaa gagcaaattt tcattttaaa gcacacctga gatgattctc atacaaccga     6060

aattttagat ccatagccct atttgatact tgacagtgca agtttctgta atttaaaaag     6120

atgtggtggc ctgacacctg caatcccaac attttgggag gccaaggtgg gagggtccct     6180

tccttgagcc cagcagtttg agaccaatgt agtgagactc atctctgcca aaaaaaaaaa     6240

attagccggg catggtggca cacatctcta gtcccaatta ctcaggaggc tgaggcgaga     6300

gaatcgcttg agcctgggac attgaggctg cagtgaactg tgatggcaca actgcatttc     6360

agcccgggag acagcaagat tctgtctc                                        6388


<210>  7
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Val Phe Ser Arg Arg Gly Gly Leu Gly Ala Arg Asp Leu Leu Leu 
1               5                   10                  15      


Trp Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Ile Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Val 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Thr His Arg Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gln Trp Ser Ala Glu Cys Ser Ile His Leu Glu Leu Ile Ala Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Lys Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Arg Gly Arg Glu Gln Ile Ile Phe Ile Pro Glu 
    130                 135                 140                 


Ser Arg Leu Leu Asn Ser Arg Phe Pro Ile Glu Gly Ala Ala Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Ala Asn Ala Leu Leu Thr Tyr Thr Leu Ser Pro Ser Asp 
                165                 170                 175     


Tyr Phe Ser Leu Asp Val Glu Ala Ser Asp Glu Leu Ser Lys Ser Leu 
            180                 185                 190         


Trp Leu Glu Leu Arg Lys Tyr Leu Asp Arg Glu Glu Thr Pro Glu Leu 
        195                 200                 205             


His Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Gln Gly 
    210                 215                 220                 


Thr Val Glu Leu Leu Ile Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Leu Phe Asp Gln Ala Val Tyr Arg Val His Leu Leu Glu Thr Thr Ala 
                245                 250                 255     


Asn Gly Thr Leu Val Thr Thr Leu Asn Ala Ser Asp Ala Asp Glu Gly 
            260                 265                 270         


Val Asn Gly Glu Val Val Phe Ser Phe Asp Ser Gly Ile Ser Arg Asp 
        275                 280                 285             


Ile Gln Glu Lys Phe Lys Val Asp Ser Ser Ser Gly Glu Ile Arg Leu 
    290                 295                 300                 


Ile Asp Lys Leu Asp Tyr Glu Glu Thr Lys Ser Tyr Glu Ile Gln Val 
305                 310                 315                 320 


Lys Ala Val Asp Lys Gly Ser Pro Pro Met Ser Asn His Cys Lys Val 
                325                 330                 335     


Leu Val Lys Val Leu Asp Val Asn Asp Asn Ala Pro Glu Leu Ala Val 
            340                 345                 350         


Thr Ser Leu Tyr Leu Pro Ile Arg Glu Asp Ala Pro Leu Ser Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Thr Val Ser Asp Arg Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Met Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Leu Ser Val Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Asn Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Val Gly Gly Thr Ile Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Arg Leu Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Ala Ala Gly Gly Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Val Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Leu Ser Arg Tyr Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Val Ala Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Val Pro Pro Thr Glu Gly Ala Tyr Val Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Leu Gly Ser Trp Ser Asn Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Ser Glu Gly Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Gly Leu Ser Pro Ser Leu Asn Thr Ser Glu 
    770                 775                 780                 


Arg Asn Glu Gln Pro Glu Ala Asn Leu Asp Leu Ser Gly Asn Pro Arg 
785                 790                 795                 800 


Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met 
                805                 810                 815     


His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro 
            820                 825                 830         


Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu 
        835                 840                 845             


Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser 
    850                 855                 860                 


Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly 
865                 870                 875                 880 


Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile 
                885                 890                 895     


Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp 
            900                 905                 910         


Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr 
    930                 935                 940                 


Thr Asp Asn Ser Asp Gln 
945                 950 


<210>  8
<211>  1281
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1130)..(1130)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1163)..(1163)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1211)..(1211)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1213)..(1213)
<223>  n is a, c, g, or t

<400>  8
tcctgcgata tacgtcgacc cacgcgtccg cttcacgccc aggccaaccg tgcactgctg       60

caatgggctc tgagctggag acggcgatgg agaccctcat caacgtgttc cacgcccact      120

cgggcaaaga gggggacaag tacaagctga gcaagaagaa gctgaaagag ctgctgcaga      180

cggagctctc tggcttcctg gatgcccaga aggatgtgga tgctgtggac aaggtgatga      240

aggagctaga cgagaatgga gacggggagg tggacttcca ggagtatgtg gtgcttgtgg      300

ctgctctcac agtggcctgt aacaatttct tctgggagaa cagttgagca gacagccaca      360

ttgggcagcg cccttcctct ccaccctccc agacctgcct cttccccctg cttccacctc      420

accccactta tccctctcca taaccccacc cctgcccacc ccacccccac ccccaccaag      480

ggcgcacaga gtaacgcgcc ccctggcctg cactctcacc ccctcatttc aacatcaact      540

ctcactaccc ggggccgttc accgccaccg gggccggccc cgcccccccc ccttcgcccc      600

cctcagcggg cgtcccctgc tctctctccc ccgcactcgc agccatttcc cctggccaca      660

cacagactcc tcccttccgc cgtatcgcct cccctccccc tcgccctacg cctccatcgc      720

acccttagca tcacgcctat cccactacac ctcgccgact ccgtccacta ctctgtcttt      780

tcctcctccg cgcccctctc ctcacgcgca ccgcgaacgc cttctcgcgc accatcgcat      840

cgccatgtgc cattgccaga gacgcgccct cgcttcccaa ccacctcact tgcctgccgc      900

cacacgaccc acttgtactg ccgccgtact tcgcacgcct gcaagattac tctacccaca      960

ttctcgccct ctcaatctat cacctccaca atcctatcat atccacgact ccactctcac     1020

actcaacgcg tatcgccacc cgctagcgcc gctctgtctc tcctgcgcct gcgccgcgac     1080

actcagtgcg ctctactctc taccactgcc tcgtaacgcg cgtactacgn gctcccgcgc     1140

ggccgtgtac gtacggccga atnctcgcac gcggcagcga gcactgacgt gtacatgtac     1200

gtcgcgcacc ncngtcggac ttcctctcgc atagccctcg tatatacccc cgtatagtca     1260

gccatgtgct cgccatctcg c                                               1281


<210>  9
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gly Ser Glu Leu Glu Thr Ala Met Glu Thr Leu Ile Asn Val Phe 
1               5                   10                  15      


His Ala His Ser Gly Lys Glu Gly Asp Lys Tyr Lys Leu Ser Lys Lys 
            20                  25                  30          


Glu Leu Lys Glu Leu Leu Gln Thr Glu Leu Ser Gly Phe Leu Asp Ala 
        35                  40                  45              


Gln Lys Asp Val Asp Ala Val Asp Lys Val Met Lys Glu Leu Asp Glu 
    50                  55                  60                  


Asn Gly Asp Gly Glu Val Asp Phe Gln Glu Tyr Val Val Leu Val Ala 
65                  70                  75                  80  


Ala Leu Thr Val Ala Cys Asn Asn Phe Phe Trp Glu Asn Ser 
                85                  90                  


<210>  10
<211>  2651
<212>  DNA
<213>  Homo sapiens

<400>  10
attgtgggaa gtatagggcg gcaagcggag gaggcgtggc gagcggatca tccgcttccg       60

gagtcgaggt tttcgggctt gtaccgcttg gcggtgcggc ctggtgtcgg cttgcaggtt      120

ctttctgtgt ttgttctctg ccctgccaag gccgtagagc tggtgcgtgc gggtagcggg      180

gctctccgag gagccgcacg ccggcggcac catggtccac ctcactactc tcctctgcaa      240

ggcctaccgt gggggccact taaccatccg ccttgccctg ggtggctgca ccaatcggcc      300

gttctaccgc attgtggctg ctcacaacaa gtgtcccagg gatggccgtt tcgtagagca      360

gctgggctcc tatgatccat tgcccaacag tcatggagaa aaactcgttg ccctcaacct      420

agacaggatc cgtcattgga ttggctgcgg ggcccacctc tctaagccta tggaaaagct      480

tctgggtctt gctggctttt tccctctgca tcctatgatg atcacaaatg ctgagagact      540

gcgaaggaaa cgggcacgtg aagtcctgtt agcttctcag aaaacagatg cagaagctac      600

agatacagag gctacagaaa cataaatgag ctgactttag tgagcatagc agtgggaaca      660

aggtcaaggt ccttttgaaa cactgcagcg atcttaattt tgttagattt ggagttcaat      720

aaatggagta tcctgagttg cccttgctct tctggcctgg cctgcacagg gcccagggag      780

agatttgttc ttgtgtgact tagagctggg tgtgggtact aattagcttt tttcgacttt      840

gtcttgggat agacagtggc tatgggagga ttggactttt gagttgggct ctgggtctct      900

tggacaactt tacaatttac tggcttccaa gacttcctgc ttcaaaaccc ccagccagac      960

tattcatggc ccattcagat cttcatgttc atcccacaag tgcaagaaca gttaaccttt     1020

cttaattgat ttttgtaatt ggaggtttat attgtcttgc ctaatgcata ttctcttttt     1080

tttttttttt ttgagacgga gtcttgttct gttgccaggc tggagtgcgg tggtgcaatc     1140

tcagctcact gcaatctcca cctcctgggt tcaagaggtt ctcctgcctc agcctcctga     1200

gtagccgggg agctacaagc atgcaccacc acacccagct aatttttttt ttttttttga     1260

gaggagtctc gctctgtcgc ccaggcttga gtgcagtggc gcgatctcgg ctcactgcaa     1320

gctctgtctc ctgggttcat gccattctcc tgcttcagcc tcccgagtag tcccaggagt     1380

agctgggact acaggtgccc accaccacac ccagctaatt tttttgtatt tttagtagag     1440

atggggtttc accatgttat ccaggatggt tttgatctcc tgacctcgtg atccgcccgc     1500

cttggcctcc caaaagtgct gggattatag gcgtgagcca ccgcccgggc aaatttttgt     1560

atttttagta gagatggggt ttcaccgtgt tggccaggat ggtctcaatc tgaccttgtg     1620

atctgcccac ctcggcctcc caaagtgcta ggattactgg cgtgagccac cactcctagc     1680

cttaatgcat attcttaaat atacaaaggt agatttgtta tgaaaattgc tttggggctc     1740

taataaccta ccttttaaga atgagaaact gctgggctta agggagttca gtatgaatca     1800

agattgaacc attcaaatgt ggctgtgatt tctgcatata tcatagatgg gatccttctg     1860

agaatactgg aatagggaat taggacacca agccaattca gctgtgaacc ttattcttgt     1920

acttttcttt cttgctggta attttatgga gcaggttaag aaggctgctc tgtgttagga     1980

taaactgtat accaataatg ttgacaacct gtaatgagtg ttgcatttta cttcttgtat     2040

cttttccttc ctaccttgat gccagtaatc tataagggat ctttatagtt tgaatgtatt     2100

tgaataactt cagtatactt tagttctact tttttatttg actcacaacc attcttaggt     2160

ctcaagtatt cccatgtgtt ttaaaagcct gaagtcagtg agatgaaatt caacatcaag     2220

aatttgaagt aacttgtaag gaaaaataat ataaagatac cattggggca gtggctcaca     2280

cctgtaatct cagcactttg ggaggctgag gtggaaggat cacttgaagc cagagtttga     2340

gaccagcctg tgcaacacag caagaccccg tctctacaaa aacttaaaaa attagctggc     2400

tgtggtgttg ctcacccata gttccagcta ctcgggaagc tgaggcagta agatcacttg     2460

agcccaggag gccgatgctg cagtgaactg tgattgttcc actacagtcc agcctgggtg     2520

acagagaaaa gaaaaagaaa acattacata atttggctag agcataataa tttgattttc     2580

tggtttttga aaatttgagt tgcaataaaa ggatatttca gtgtgcgatt tcaaaaaaaa     2640

aaaaaaaaaa a                                                          2651


<210>  11
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Val His Leu Thr Thr Leu Leu Cys Lys Ala Tyr Arg Gly Gly His 
1               5                   10                  15      


Leu Thr Ile Arg Leu Ala Leu Gly Gly Cys Thr Asn Arg Pro Phe Tyr 
            20                  25                  30          


Arg Ile Val Ala Ala His Asn Lys Cys Pro Arg Asp Gly Arg Phe Val 
        35                  40                  45              


Glu Gln Leu Gly Ser Tyr Asp Pro Leu Pro Asn Ser His Gly Glu Lys 
    50                  55                  60                  


Leu Val Ala Leu Asn Leu Asp Arg Ile Arg His Trp Ile Gly Cys Gly 
65                  70                  75                  80  


Ala His Leu Ser Lys Pro Met Glu Lys Leu Leu Gly Leu Ala Gly Phe 
                85                  90                  95      


Phe Pro Leu His Pro Met Met Ile Thr Asn Ala Glu Arg Leu Arg Arg 
            100                 105                 110         


Lys Arg Ala Arg Glu Val Leu Leu Ala Ser Gln Lys Thr Asp Ala Glu 
        115                 120                 125             


Ala Thr Asp Thr Glu Ala Thr Glu Thr 
    130                 135         


<210>  12
<211>  5114
<212>  DNA
<213>  Homo sapiens

<400>  12
ggaataagtg acatcatgag tgtgtgccag gtgtctgatt acagaaggtg ttcaattaat       60

ctgcaatcat taattaaccc ttcagtcgct ggtattattt gccatccatc ctccgagtgt      120

tgccaagtta tgggtgcgtt ctgccagcgt cctagcagtg gtaaggcttc tggctgccag      180

cggcgaacct ctcccttcga gtatttctcc tcttgctgag atgaaatgcg accgggtctc      240

tttaagggcc aggcgccggg atccaggcgg cgcccaacgg ctggactagc agtcgtccgc      300

gccgactcgc acaagaagga accccgggcc tctggatccg ctcgcccggc tatgctgctg      360

tggccgctgc ggggctgggc cgcccgggcg ctgcgctgct ttgggccggg aagtcgcggg      420

agcccggcct caggccccgg gccgcggagg gtgcagcgcc gggcctggcc tcccgataaa      480

gaacaggaaa aagagaaaaa atcagtgatc tgtgtcgagg gcaatattgc aagtgggaag      540

acgacatgcc tggaattctt ctccaacgcg acagacgtcg aggtgttaac ggagcctgtg      600

tccaagtgga gaaatgtccg tggccacaat cctctgggcc tgatgtacca cgatgcctct      660

cgctggggtc ttacgctaca gacttatgtg cagctcacca tgctggacag gcatactcgt      720

cctcaggtgt catctgtacg gttgatggag aggtcgattc acagcgcaag atacattttt      780

gtagaaaacc tgtatagaag tgggaagatg ccagaagtgg actatgtagt tctgtcggaa      840

tggtttgact ggatcttgag gaacatggac gtgtctgttg atttgatagt ttaccttcgg      900

accaatcctg agacttgtta ccagaggtta aagaagagat gcagggaaga ggagaaggtc      960

attccgctgg aatacctgga agcaattcac catctccatg aggagtggct catcaaaggc     1020

agccttttcc ccatggcagc ccctgttctg gtgattgagg ctgaccacca catggagagg     1080

atgttagaac tctttgaaca aaatcgggat cgaatattaa ctccagagaa tcggaagcat     1140

tgcccatagg aggcaaaagg tctatggctc atgtctgaaa aatgcctgct gctgccaagt     1200

tagctattgg gagcaatctg gaaaaacttg ctcccaggag ggctttgtgt ctggccagct     1260

tgattttcct aatggtctca tctcctttgc tagtgtcttt gtcatgcgtc tctggccctc     1320

gtgggtaaat gacaaacggg accaatgggt ttgccaagcc ctttgctgtt cgcagcctca     1380

cattcccccg gtgcctctcc catggctttg tgctgctgag tcgctctcat gaagccctta     1440

gggagagcac ctgttgtgtg cctgacacca cgctggagct gtgtaccaat cgtctcagcc     1500

ttcattagga ggccgaggta ggagtcttat atcccaggtg aggaatttga agctcagaaa     1560

ggttgagggg ctccccagag gtcacacagc ctgtgtgcag tggagctggc accattcaga     1620

ctttcagccg actcagcaac tttcccttgc cctgggctgc ctcctcctga gagctgttcc     1680

ccaccgccct gcctcttccg gttggaggct ctcatgtctc tttggggaga gctggcagtg     1740

tgcggagctg ataacatttt cccaatattg agcagttccc aaggacagtc agcatttcta     1800

gacttccaca aaattatgct gcatttggct ggagcccggt gttcagtggt ttccctgccc     1860

gaggtcgctg cagccccatc taccacatct tcatgtggac attgagattc acatgctggc     1920

tcctgaaggg tgctcagtct ccttggtgat taaggtcctg cttgaactgc tgccaactcc     1980

atgtcaggga agtcgctttt ggtgcctggc tggtttgccc agagccaagc tggggcaagg     2040

ggcagccagc cctggcttcc aaggctcccg tactgtctgt gtccttgtat aaggagcttt     2100

gctcttggaa ttactgaaag tctgtggccc aagagagaga cacaagtggc cttaagtctt     2160

tttgaagtgt tatttcatcc agggaaatgc ctcgagccat agagcctgaa atcatctttg     2220

ttggctcaga aaatacctta gcttcactca gctggactgc attgaaggcg aggctgcccc     2280

ttggatcaag cagaaaacaa gagaaagaaa gaacgttccc tttggggata gtctggaaag     2340

ttgggatttg caaataaagg ctctggaagc attgctggtc ctgaagcttt ggaggtgggc     2400

agagagagct tcaagaagac tagatgcaaa ccctggaaag gattaaggct caactctgga     2460

gaaacaggcc acagcctctc agagcagctg ttggctgtaa atagaggtag caaggccgct     2520

cccaggcccc tgtgagtgtg ggcacctgtg catgcaatgc tccgactctg cagaggtgcc     2580

aagtgcccct gctgggccag tcccagagag ttaggaagtc aaggcctgca actcctggtt     2640

cttcctgttt ggaccagttc ttgtgccatt ggcaggatga gaggcagcag ccaggcggga     2700

gctgtgtcta gcagcacctg tagcccacgt gctgctaatt agctggaaaa ctggcgaagg     2760

cagaaccttt gctaccagga atcttgacat gtggggtctg tctttgagaa tttgtaaatg     2820

aacagtccaa tatttcctct cggctcattt tgcacatcca tttttgggga aatgtgattt     2880

ctctctcttt tttttttttt ttttttgcct aaggcacaat ctcaagaggt cctgagacca     2940

cgtacccatg atttttttct tgctctgtga tacccaataa ctccttcacc taagccctgt     3000

tgttgatttt gaagtgcttc ctaggccagt gattttagct tctgccagct gcttttgcca     3060

gtagattaac gtgtttttat ttttcaaact ccgtgtttcc taacgtggag tgtatgggtc     3120

taagagagcc tgctgtcctc cctgccttcc accttggaga ggaggctgga cgcatcagca     3180

gtggccaggg caggtcgcaa aatctcccag cctagagacc acacctgaaa cggctgaagc     3240

cagcttgcac aagggctgct gtccctctgc ggcaggcaga gctggtgggg gcaggggtca     3300

cagagcagtc atagacacca tggaccaggg caggagaagg gcagatggca catgggcaca     3360

acagggcctt gtccttagag cactgggggg tcatggctgg gaggggcatg gcaggggctg     3420

gcatccctgt agagccagag gggccaccca gggcagtgac attccagata tgttgggctc     3480

acctcatcct tgctgtgaga ctggagttcc atggggacat gaagtcagta caccgcagag     3540

ctgctcagct gctctacctc tcgctgactt ttttgttgca catatacatt ttctttcaat     3600

tagcatttat ttcagctttt atttaagctt tttgacagta catgtaaaat atatgattat     3660

aaccatttaa aaatacctta tgtacctggt tttttttgga aactagatag aaatatattt     3720

atcttttaca taaaagaagt gtgtagtggg gtggtccagg gctttgtggt ggcttagtgg     3780

ccatcggggt cccaggctct tcccaccttt ctcttttggg tccacctctt ggctcctggc     3840

ttccttcctc tggggcctga ctgtccagga tggcagctgg agctcctgct ctgggcacgg     3900

ttggcatcag agcccactgc tccccatcca ctctttaatc cagatgctgg taatgtccct     3960

ttccaaggca taactaagat aagctggaag gttcttacga ggctttgcta gaggccctgg     4020

gaggtggggg gaaaggcaag agggcagtgc ccacccatag accgggtcac atgacctggc     4080

atcagcgccg tggggtcctt tgggcttcac ctccctctcc cctctgcccc cacgtcatcc     4140

caccctcatc ctcaccctca ccattcccat cccgtaccgt aatgtccctt gcaaggccta     4200

actctgtgag gaatgaaacc acctcatcct tgttccaata acatgagtga ccgaatttac     4260

aaacgagtga atgtggacct ctggaaacat tacccagctt gtttttactt ttcactttct     4320

ctttctgccc ctttcatttc cgtaggagcc ctttacctag atgagaagtg tccccccgcc     4380

tggggaatat atcagtcaga acaatcttcc tgcagacatg caccattaga cccgagtgac     4440

ggtggtgcca tttaaacctc agagcaggta aaaggtggtc ctgaaacctg tctacccaca     4500

gggtgctatg gaatctgaat cacttctttt ttcctagagc cctggggtgg ggagctccct     4560

caagtgttca catgtgtgtg gaatgaggaa cacccatctc cttggccctc tccaccctga     4620

agagttagtt attaaaataa ttggcaagct cttgcaaatg tcagtcatcc attgttcaga     4680

atggaatagc aataatacat ccctggctgc cctgggcttg gccaggatta ctcactgaag     4740

gcctcagggt tactggcaca cactttcttt tcctaataat cccatcccct cagctttcct     4800

aaggctagag tgaatttcgt gttcctttag tttacataag atggtgaact tggcaaaagc     4860

tatcattaaa cagaagctaa gagaaagcct atgtcgtgga atccagaatg ggtattgcca     4920

ttcactgctg tccacagaag ctgtcttgaa tttctttctg tgtcttttct ttttttttct     4980

ttaagactgt tgtttaccag actgggctct gtggaacaca ggtgtcctgg gagatggtta     5040

atcattacaa aatattggta acaatctaaa gatgcataca taagagagtg gtcaaataaa     5100

ccattttcca ttca                                                       5114


<210>  13
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Leu Leu Trp Pro Leu Arg Gly Trp Ala Ala Arg Ala Leu Arg Cys 
1               5                   10                  15      


Phe Gly Pro Gly Ser Arg Gly Ser Pro Ala Ser Gly Pro Gly Pro Arg 
            20                  25                  30          


Arg Val Gln Arg Arg Ala Trp Pro Pro Asp Lys Glu Gln Glu Lys Glu 
        35                  40                  45              


Lys Lys Ser Val Ile Cys Val Glu Gly Asn Ile Ala Ser Gly Lys Thr 
    50                  55                  60                  


Thr Cys Leu Glu Phe Phe Ser Asn Ala Thr Asp Val Glu Val Leu Thr 
65                  70                  75                  80  


Glu Pro Val Ser Lys Trp Arg Asn Val Arg Gly His Asn Pro Leu Gly 
                85                  90                  95      


Leu Met Tyr His Asp Ala Ser Arg Trp Gly Leu Thr Leu Gln Thr Tyr 
            100                 105                 110         


Val Gln Leu Thr Met Leu Asp Arg His Thr Arg Pro Gln Val Ser Ser 
        115                 120                 125             


Val Arg Leu Met Glu Arg Ser Ile His Ser Ala Arg Tyr Ile Phe Val 
    130                 135                 140                 


Glu Asn Leu Tyr Arg Ser Gly Lys Met Pro Glu Val Asp Tyr Val Val 
145                 150                 155                 160 


Leu Ser Glu Trp Phe Asp Trp Ile Leu Arg Asn Met Asp Val Ser Val 
                165                 170                 175     


Asp Leu Ile Val Tyr Leu Arg Thr Asn Pro Glu Thr Cys Tyr Gln Arg 
            180                 185                 190         


Leu Lys Lys Arg Cys Arg Glu Glu Glu Lys Val Ile Pro Leu Glu Tyr 
        195                 200                 205             


Leu Glu Ala Ile His His Leu His Glu Glu Trp Leu Ile Lys Gly Ser 
    210                 215                 220                 


Leu Phe Pro Met Ala Ala Pro Val Leu Val Ile Glu Ala Asp His His 
225                 230                 235                 240 


Met Glu Arg Met Leu Glu Leu Phe Glu Gln Asn Arg Asp Arg Ile Leu 
                245                 250                 255     


Thr Pro Glu Asn Arg Lys His Cys Pro 
            260                 265 


<210>  14
<211>  1413
<212>  DNA
<213>  Homo sapiens

<400>  14
atgggaagat gtgcctactt cccctttgcc ttccaccgtg actgtacatt tcctgaggac       60

tccctagcca tgctttctgt acagcctgct gaactctctg cccaaatttc agctgtcaca      120

gaatgagtga tcctcatagt ataatggaaa tgcatcatct cagtttcccc atggcctgaa      180

tgtccataca aaatgagagc cagtagagaa aaacagagga cgtgaggagt ttttaaaaat      240

tgaggaaaag tggaaggaaa agtaaggatg aaggtgaaga tgaaggaata tgtcagagat      300

gctagcactg gcatccccca ccacacagta ccatgtactg ctaaagaact ctagaacata      360

cagggtgtag acggcagtct tcttggggaa aaagaggctt caggattgca agatttcagc      420

tactgtctct cctcggagca ggattccatc ttttccatgg ctggggccct tgacacatgt      480

cactgtgcac tgctcttctc gctgggaaaa ggaaactgag gcccagagag ggcaagtgaa      540

tttcccaaga gtgtccagat gatacggagc tgagctggaa agtgagcctg gatctctctg      600

gttctgaaag ctttgctcga aagcacagga tgacacctcc attcaaccaa taagcactga      660

gacccttcca tggactcagc aggtcctgct gtccctgaag gttgacactc tcatttcaaa      720

ccacagcgag aaccccaaaa ggaaacagtg caaggaaaat aatgtgatat ttgagaggca      780

gcatgggtta ttggggacag ggttcatgtc ccttctctcc cacacacgtg gcatgatgtt      840

aagcgggtca cctcacctct ccagggttgt ttcctcaact gagaaaatga gggggttgag      900

atgaacgcca gccctggggt gctcaatgct gcagtctagg gtggtgtgga ctggaatcag      960

aattctttct cctccgctct gggtgctgac acatgatctc tggctctcac tccccacccc     1020

taatcttgcc catctgagtt tcaggttatt ttttccttcc tcctgctctt caatttcctt     1080

attgaggaag ctctttcctg ctgcctctgt ccccgctgga gctgtttgat ccagtagagc     1140

cagtcgaagc caaggggacc ctgacttgaa tcttgctttc tgacatgctg gctgtggctt     1200

gcttgggacc cgaataagag cttgcttact cccggtgttc accacagcgg aaccatgggt     1260

gcagaaatgt aattctcaac cagcccagtt taatcagcga aagacaatag agcttgcagg     1320

cggtgtcatg ctgagtatct gaacacacca tggctgctgt cgcccttttc attaaaatga     1380

ttgaaaatgt atttctaaaa aaaaaaaaaa aaa                                  1413


<210>  15
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gly Arg Cys Ala Tyr Phe Pro Phe Ala Phe His Arg Asp Cys Thr 
1               5                   10                  15      


Phe Pro Glu Asp Ser Leu Ala Met Leu Ser Val Gln Pro Ala Glu Leu 
            20                  25                  30          


Ser Ala Gln Ile Ser Ala Val Thr Glu 
        35                  40      


<210>  16
<211>  6528
<212>  DNA
<213>  Homo sapiens

<400>  16
agcggcggcg gtggtctcgg cggcggcggc ggcggcggcg gcagggagcg ggctcccggt       60

gccgggcacc gggcgggcgg cggggaagat gaccgcgggc gccggcgtgc tccttctgct      120

gctctcgctc tccggcgcgc tccgggccca taatgaggat cttacaacta gagagacctg      180

caaggctggg ttctctgaag atgattacac ggcattaatc tcccaaaata ttctagaagg      240

ggaaaagcta cttcaagtca agttcagcag ctgtgtgggg accaagggga cacaatatga      300

gaccaacagc atggacttca aagttggggc agatgggaca gtcttcgcca cccgggagct      360

gcaggtcccc tccgagcagg tggcgttcac ggtgactgca tgggacagcc agacagcaga      420

gaaatgggac gccgtggtgc ggttgctggt ggcccagacc tcgtccccgc actctggaca      480

caagccgcag aaaggaaaga aggtcgtggc tctggacccc tctccgcctc cgaaggacac      540

cctgctgccg tggccccagc accagaacgc caacgggctg aggcggcgca aacgggactg      600

ggtcatcccg cccatcaacg tgcccgagaa ctcgcgcggg cccttcccgc agcagctcgt      660

gaggatccgg tccgacaaag acaatgacat ccccatccgg tacagcatca cgggagtggg      720

cgccgaccag ccccccatgg aggtcttcag cattgactcc atgtccggcc ggatgtacgt      780

cacaaggccc atggaccggg aggagcacgc ctcttaccac ctccgagccc acgctgtgga      840

catgaatggc aacaaggtgg agaaccccat cgacctgtac atctacgtca tcgacatgaa      900

tgacaaccgc cctgagttca tcaaccaggt ctacaacggc tccgtggacg agggctccaa      960

gccaggcacc tacgtgatga ccgtcacggc caacgatgct gacgacagca ccacggccaa     1020

cgggatggtg cggtaccgga tcgtgaccca gaccccacag agcccgtccc agaatatgtt     1080

caccatcaac agcgagactg gagatatcgt cacagtggcg gctggcctgg accgagagaa     1140

agttcagcag tacacagtca tcgttcaggc cacagatatg gaaggaaatc tcaactatgg     1200

cctctcaaac acagccacag ccatcatcac ggtgacagat gtgaatgaca acccgccaga     1260

atttaccgcc agcacgtttg caggggaggt ccccgaaaac cgcgtggaga ccgtggtcgc     1320

aaacctcacg gtgatggacc gagatcagcc ccactctcca aactggaatg ccgtttaccg     1380

catcatcagt ggggatccat ccgggcactt cagcgtccgc acagaccccg taaccaacga     1440

gggcatggtc accgtggtga aggcagtcga ctacgagctc aacagagctt tcatgctgac     1500

agtgatggtg tccaaccagg cgcccctggc cagcggaatc cagatgtcct tccagtccac     1560

ggcaggggtg accatctcca tcatggacat caacgaggct ccctacttcc cctcaaacca     1620

caagctgatc cgcctggagg agggcgtgcc ccccggcacc gtgctgacca cgttttcagc     1680

tgtggaccct gaccggttca tgcagcaggc tgtgagatac tcaaagctgt cagacccagc     1740

gagctggctg cacatcaatg ccaccaacgg ccagatcacc acggcggcag tgctggaccg     1800

tgagtccctc tacaccaaaa acaacgtcta cgaggccacc ttcctggcag ctgacaatgg     1860

gatacccccg gccagcggca ccgggaccct ccagatctat ctcattgaca tcaacgacaa     1920

cgcccctgag ctgctgccca aggaggcgca gatctgcgag aagcccaacc tgaacgccat     1980

caacatcacg gcggccgacg ctgacgtcga ccccaacatc ggcccctacg tcttcgagct     2040

gccctttgtc ccggcggccg tgcggaagaa ctggaccatc acccgcctga acggtgacta     2100

tgcccaactc agcttgcgca tcctgtacct ggaggccggg atgtatgacg tccccatcat     2160

cgtcacagac tctggaaacc ctcccctgtc caacacgtcc atcatcaaag tcaaggtgtg     2220

cccatgtgat gacaacgggg actgcaccac cattggcgca gtggcagcgg ctggtctggg     2280

caccggtgcc atcgtggcca tcctcatctg catcctcatc ctgctgacca tggtcctgct     2340

gtttgtcatg tggatgaagc ggcgagagaa ggagcgccac acgaagcagc tgctcattga     2400

ccccgaggac gacgtccgcg acaacatcct caagtatgac gaggaaggcg gtggcgagga     2460

ggaccaggac tacgacctca gccagctgca gcagccggaa gccatggggc acgtgccaag     2520

caaagcccct ggcgtgcgtc gcgtggatga gcggccggtg ggcgctgagc cccagtaccc     2580

gatcaggccc atggtgccgc acccaggcga catcggtgac ttcatcaatg agggactccg     2640

cgctgctgac aacgacccca cggcaccccc ctatgactcc ctgctggtct tcgactacga     2700

ggggagcggc tccaccgcag gctccgtcag ctccctgaac tcatccagtt ccggggacca     2760

agactacgat tacctcaacg actgggggcc cagattcaag aagctggcgg acatgtatgg     2820

aggtggtgaa gaggattgac tgacctcgca tcttcggacc gaagtgagag ccgtgctcgg     2880

acgccggagg agcaggactg agcagaggcg gccggtcttc ccgactccct gcggctgtgt     2940

ccttagtgct gttaggaggc cccccaatcc ccacgttgag ctgtctagca tgagcaccca     3000

cccccacagc gccctgcacc cggccgctgc ccagcaccgc gctggctggc actgaaggac     3060

agcaagaggc actctgtctt cacttgaatt tcctagaaca gaagcactgt ttttaaaaaa     3120

aaaaaaaaaa aaagaagaaa gaaagaaaaa aaaaaaaaaa agaaagtgcc ttttggtatg     3180

tatcagattc cctcaaactc aggagtgtct aaagcagaca gaccgtcccc accttcccat     3240

cccgagcggc ctccaacccc agctagtccc agctctgaag gcatcattca gaaatggggg     3300

agactgtgtc tgtctttctt actttttttt tggtctttta ttaagaaaaa gaaagtgggt     3360

gacttgtttg aaaacagagt ggggttcaaa tcccagcagc ctttgctgta cacagctggg     3420

ggtctcttga gcctcttggg agtcaaggcc agctgggagg cttagccctt cagccccagc     3480

agaaggccct ggggctggtg gggctcagaa tacccctacc ttgtggctgc tccccacccc     3540

tcccggatgc tgtgaggagc tcaggcaggg gcctggaggg gaacaggggt catcctgaag     3600

gggctccacc cccagtcaac ccaggcctcc ctcagggaca cctgtcaccc tgagtgccac     3660

caggtcccct ctgcctttgg tccagaagag tgagttgtcc aaaccagcca gcatctggct     3720

ccagccctcc aaccctggcg accagacccc atggggtgcc atcaacggcc ccgcgacagg     3780

catcaattca aaccccagga cactctcgac agctccaacc atccggaggg ctgtgcagat     3840

ggcaggaacc aaggaccctc cctggcagct gaagagggca gttacggttg ggcgtggtga     3900

ccagaacaca cccagcagcc tgcgaagcct ccccgtcccc agcctgtgct cctgattccc     3960

gccagacgct tgtgagcctg tgtgggtggc aggaggcccc gtcttgccgt gcctacctgt     4020

cgcacagatg cctctgcacg ctgcagacgg tgcctctcct ctcctatgga ccctcgtcgg     4080

gggcaggcag cggccgggtc caaacttgct gctgtcctcg aggctggcac tgctatctcc     4140

agggctgggt tgactcaagc cagacagggg gaaggaattg gttctgcagg acagtgagag     4200

ggtctgtgtc ccggcacccc tgggacagcg ctcggctgcc tgtgctcact gcatgagaaa     4260

actcagaggg tgcattctcc ctctggcatg gctgtgtctg ggcgccttgg gctgcggcag     4320

ggggcaggcc ccacgtgggg aagcctcgtg cttggtcagc tttctgtctc tcccaggcca     4380

gtgacaactg gcttcccgag gaaggaggtg aggtaccagg gaccctgggc aggacctggt     4440

gtcgggcagg gcggtgccag cactggggaa ggacagggag ccctcccgga gccccaccct     4500

gcacctgcca ctggggtcag ggagtgtctc ggggtgcctt tgggggcagc atgagctcca     4560

ccaggggccc cggcccccac ctcagcctat ggcccttccc catggctaag gtcatgcctt     4620

ttctgaacag ctttggcctt gagtgcacac atctgtgcca ggctcacggc atgttcccgt     4680

tggatgtcag ggtccttgtc caaaccaaac tcacagctgc ccctgtgcag ccttcagagt     4740

tgagctgggg tctcagtctc caacctgtcc tttctgaccc tcccatggct gcccagggag     4800

ggcggggttc actgtgccac gtgctgggtg cccccctctg cagacagcca gtccaggaga     4860

tggaccaaca gaggtcaagg ggcagctggc caggccgcac cggggtcccc gagttctgag     4920

ctgtgctatg caaacaagaa tgctcctgtg tgggggggca tggccgttgg aggtatagct     4980

gggcgggtag tggaaggact ggaaatctct gttgttgttt ggggaagtcc atgcttcagt     5040

ccttcggagt atgcgtggat tgttcgaagt gtgactatgg cccgggagcc agggcagcat     5100

gaactccttt ctctgaaatt tcgaggcctc cttgggttcc ctgaactccg ggctgatgtt     5160

cccaggaccc agcaccagga gaccccagtc ccgccagcag ccgccgctac ccaggagggc     5220

tgggcgacat tggccgcctc ccactagctc cccctcctcg cccacagcct cttgtcactg     5280

ccaagccccc gttccttttg cccaaatcac gcaggcggaa gctgcagtgc cagctggagg     5340

gatgttcata gggcttcctg tgcccatccc tgctccaaac agctggacag cttcccctct     5400

acccccaccc tggtgagccc ctgggggcca gagaaagatg gggttcctgc accttcccag     5460

ctccacctct gaacttgagt tagcgttagc taagcataca atcagtgtcg aacgtctctc     5520

ttccttaagc ttgtagatac gactgcctat aatcagggga ctcccactgg aggccgggag     5580

gccaatgctg gccaggtgcg agggcatggt ttggttcctt tagggaattt ttgttttgca     5640

aacaggagaa acctgtgctg caggttggag tggcaggaac gactggcctt ggtcagcagg     5700

cagcccccag cctagggcca cagtcctctt cagggcctgg gcagccccaa tttctggccc     5760

agcaggtttc tctttgtagt gtctttcagc acatccaaaa tgctaggcct cctgccacca     5820

acgtgtcaga gcaatgtcca actgtcaggc tctcagagat gcctcagttt ccctagcatg     5880

agcaccagcc gacacacaca gtccactgag atgataattc tgttctctcc aaagcaaaaa     5940

gctgggcgag gggtagtctc aatttctgtc agtgctcaaa ggaataacac caaaagaatc     6000

aacacagaat ctcccagaca cacgtgaccc agctcgtggc gccgtgggtc cgtaggaggg     6060

acagtacctc acaacaggcc cagcggggga ccacctctct gtacaattgg aatgcgtttt     6120

acttttcttt tctctccttt tttcattccg attttttttg catgtttctt tttgaaatgg     6180

gcaaaatgtg tagcagcctg catgagcaca gttgttttgg ggaaagatac tggagtatga     6240

tgtactcaca cctgcaaatc tgagcatcgc gaggttaaac gttccacctt tttttgtaat     6300

cgtcaacagc acaactattt tgtattgttg tttgtatcat tttgtaccaa aaaaaaaaag     6360

gaaaaaaaaa gggaagagag ttgatgtttt cagtgtgttt ccagtgccag acagtcttgg     6420

tcctgaactc agtagaccct tgcggagcgg ttgtgcgcgg gcaggcgggg cgcgctgctc     6480

cagagaatga ataaagtccc ccttttccgt aaaaaaaaaa aaaaaaaa                  6528


<210>  17
<211>  916
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Thr Ala Gly Ala Gly Val Leu Leu Leu Leu Leu Ser Leu Ser Gly 
1               5                   10                  15      


Ala Leu Arg Ala His Asn Glu Asp Leu Thr Thr Arg Glu Thr Cys Lys 
            20                  25                  30          


Ala Gly Phe Ser Glu Asp Asp Tyr Thr Ala Leu Ile Ser Gln Asn Ile 
        35                  40                  45              


Leu Glu Gly Glu Lys Leu Leu Gln Val Lys Phe Ser Ser Cys Val Gly 
    50                  55                  60                  


Thr Lys Gly Thr Gln Tyr Glu Thr Asn Ser Met Asp Phe Lys Val Gly 
65                  70                  75                  80  


Ala Asp Gly Thr Val Phe Ala Thr Arg Glu Leu Gln Val Pro Ser Glu 
                85                  90                  95      


Gln Val Ala Phe Thr Val Thr Ala Trp Asp Ser Gln Thr Ala Glu Lys 
            100                 105                 110         


Trp Asp Ala Val Val Arg Leu Leu Val Ala Gln Thr Ser Ser Pro His 
        115                 120                 125             


Ser Gly His Lys Pro Gln Lys Gly Lys Lys Val Val Ala Leu Asp Pro 
    130                 135                 140                 


Ser Pro Pro Pro Lys Asp Thr Leu Leu Pro Trp Pro Gln His Gln Asn 
145                 150                 155                 160 


Ala Asn Gly Leu Arg Arg Arg Lys Arg Asp Trp Val Ile Pro Pro Ile 
                165                 170                 175     


Asn Val Pro Glu Asn Ser Arg Gly Pro Phe Pro Gln Gln Leu Val Arg 
            180                 185                 190         


Ile Arg Ser Asp Lys Asp Asn Asp Ile Pro Ile Arg Tyr Ser Ile Thr 
        195                 200                 205             


Gly Val Gly Ala Asp Gln Pro Pro Met Glu Val Phe Ser Ile Asp Ser 
    210                 215                 220                 


Met Ser Gly Arg Met Tyr Val Thr Arg Pro Met Asp Arg Glu Glu His 
225                 230                 235                 240 


Ala Ser Tyr His Leu Arg Ala His Ala Val Asp Met Asn Gly Asn Lys 
                245                 250                 255     


Val Glu Asn Pro Ile Asp Leu Tyr Ile Tyr Val Ile Asp Met Asn Asp 
            260                 265                 270         


Asn Arg Pro Glu Phe Ile Asn Gln Val Tyr Asn Gly Ser Val Asp Glu 
        275                 280                 285             


Gly Ser Lys Pro Gly Thr Tyr Val Met Thr Val Thr Ala Asn Asp Ala 
    290                 295                 300                 


Asp Asp Ser Thr Thr Ala Asn Gly Met Val Arg Tyr Arg Ile Val Thr 
305                 310                 315                 320 


Gln Thr Pro Gln Ser Pro Ser Gln Asn Met Phe Thr Ile Asn Ser Glu 
                325                 330                 335     


Thr Gly Asp Ile Val Thr Val Ala Ala Gly Leu Asp Arg Glu Lys Val 
            340                 345                 350         


Gln Gln Tyr Thr Val Ile Val Gln Ala Thr Asp Met Glu Gly Asn Leu 
        355                 360                 365             


Asn Tyr Gly Leu Ser Asn Thr Ala Thr Ala Ile Ile Thr Val Thr Asp 
    370                 375                 380                 


Val Asn Asp Asn Pro Pro Glu Phe Thr Ala Ser Thr Phe Ala Gly Glu 
385                 390                 395                 400 


Val Pro Glu Asn Arg Val Glu Thr Val Val Ala Asn Leu Thr Val Met 
                405                 410                 415     


Asp Arg Asp Gln Pro His Ser Pro Asn Trp Asn Ala Val Tyr Arg Ile 
            420                 425                 430         


Ile Ser Gly Asp Pro Ser Gly His Phe Ser Val Arg Thr Asp Pro Val 
        435                 440                 445             


Thr Asn Glu Gly Met Val Thr Val Val Lys Ala Val Asp Tyr Glu Leu 
    450                 455                 460                 


Asn Arg Ala Phe Met Leu Thr Val Met Val Ser Asn Gln Ala Pro Leu 
465                 470                 475                 480 


Ala Ser Gly Ile Gln Met Ser Phe Gln Ser Thr Ala Gly Val Thr Ile 
                485                 490                 495     


Ser Ile Met Asp Ile Asn Glu Ala Pro Tyr Phe Pro Ser Asn His Lys 
            500                 505                 510         


Leu Ile Arg Leu Glu Glu Gly Val Pro Pro Gly Thr Val Leu Thr Thr 
        515                 520                 525             


Phe Ser Ala Val Asp Pro Asp Arg Phe Met Gln Gln Ala Val Arg Tyr 
    530                 535                 540                 


Ser Lys Leu Ser Asp Pro Ala Ser Trp Leu His Ile Asn Ala Thr Asn 
545                 550                 555                 560 


Gly Gln Ile Thr Thr Ala Ala Val Leu Asp Arg Glu Ser Leu Tyr Thr 
                565                 570                 575     


Lys Asn Asn Val Tyr Glu Ala Thr Phe Leu Ala Ala Asp Asn Gly Ile 
            580                 585                 590         


Pro Pro Ala Ser Gly Thr Gly Thr Leu Gln Ile Tyr Leu Ile Asp Ile 
        595                 600                 605             


Asn Asp Asn Ala Pro Glu Leu Leu Pro Lys Glu Ala Gln Ile Cys Glu 
    610                 615                 620                 


Lys Pro Asn Leu Asn Ala Ile Asn Ile Thr Ala Ala Asp Ala Asp Val 
625                 630                 635                 640 


Asp Pro Asn Ile Gly Pro Tyr Val Phe Glu Leu Pro Phe Val Pro Ala 
                645                 650                 655     


Ala Val Arg Lys Asn Trp Thr Ile Thr Arg Leu Asn Gly Asp Tyr Ala 
            660                 665                 670         


Gln Leu Ser Leu Arg Ile Leu Tyr Leu Glu Ala Gly Met Tyr Asp Val 
        675                 680                 685             


Pro Ile Ile Val Thr Asp Ser Gly Asn Pro Pro Leu Ser Asn Thr Ser 
    690                 695                 700                 


Ile Ile Lys Val Lys Val Cys Pro Cys Asp Asp Asn Gly Asp Cys Thr 
705                 710                 715                 720 


Thr Ile Gly Ala Val Ala Ala Ala Gly Leu Gly Thr Gly Ala Ile Val 
                725                 730                 735     


Ala Ile Leu Ile Cys Ile Leu Ile Leu Leu Thr Met Val Leu Leu Phe 
            740                 745                 750         


Val Met Trp Met Lys Arg Arg Glu Lys Glu Arg His Thr Lys Gln Leu 
        755                 760                 765             


Leu Ile Asp Pro Glu Asp Asp Val Arg Asp Asn Ile Leu Lys Tyr Asp 
    770                 775                 780                 


Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Tyr Asp Leu Ser Gln Leu 
785                 790                 795                 800 


Gln Gln Pro Glu Ala Met Gly His Val Pro Ser Lys Ala Pro Gly Val 
                805                 810                 815     


Arg Arg Val Asp Glu Arg Pro Val Gly Ala Glu Pro Gln Tyr Pro Ile 
            820                 825                 830         


Arg Pro Met Val Pro His Pro Gly Asp Ile Gly Asp Phe Ile Asn Glu 
        835                 840                 845             


Gly Leu Arg Ala Ala Asp Asn Asp Pro Thr Ala Pro Pro Tyr Asp Ser 
    850                 855                 860                 


Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly Ser Thr Ala Gly Ser Val 
865                 870                 875                 880 


Ser Ser Leu Asn Ser Ser Ser Ser Gly Asp Gln Asp Tyr Asp Tyr Leu 
                885                 890                 895     


Asn Asp Trp Gly Pro Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly 
            900                 905                 910         


Gly Glu Glu Asp 
        915     


<210>  18
<211>  2103
<212>  DNA
<213>  Homo sapiens

<400>  18
agtttaacat ggtggccacc ttgctgtgat ggaggagtgg gcctagagga aagatgcttc       60

cttctgcctg aatgactagg gtggattcct aggaattgac ccctgggctg aggcttgaag      120

gagtcaccaa ggagagggta aagggtgtcc cagacaacta gaacagcaga agcaaaggca      180

cagaatgtga cacagctgat gggggtgggg gagacctgca acagtcctgc atcactggaa      240

tgcagagtga aaggagggga gtcgacagga gtgaggacga agcttgctgg gggccaggtg      300

gtgcaggctc tgcaccctgg gaccaaacag tctctttcct cttttcccac acctcaaatc      360

tctgccttcc atttcacacc cagcacaagt accccaagga ggagccccat ccccaagggc      420

ccaaagagac tggccacttt gctcttagag cccacagcca cagtagtcag cttgtctaca      480

gcagttcctc gtgtatgacc atacaaatac atcacctgac caccttgtta gatgcccctc      540

tgactcatag gtctggaatg ggccctgaaa tcctgcactg ggcttccaag agatgctgct      600

gctggtctgc aggccagacc acactttcag ttgcaaagca cctgagggtc tgtataccag      660

aaaaggcagt tgcaggccaa atctacataa agtggacctg tgccaggaac aaactgtgct      720

tctacttggg acattatctc acgagtggtg gctacggagt cagagcccag agaacaggat      780

ggtcttaagc actgttctcc ctgagctgtg acaaacggtc ctctgctgtg gggaggtacc      840

tgtggagccc agaagggagc aggggtcggg ctagagacac cgcaatgatt cttttcctcc      900

agaaatgctt catctaaagc acagatctac acctttagaa ttccagtata ttacttaatt      960

tcagtattcc ttacaatata gtttggatgt ttgtctcctc gaaatctcct gttgaaaact     1020

gatccccagt gttggaggtg gggcctagag ggaggtattt gggtcatggg agcagattcc     1080

tcatgaaggg cttggtgcca tcctcgcagt aatgagtgct tgttctattc gttcctgcaa     1140

gaactagttg ttttaaaaga acctggcctc ggctgggcac ggtggctcac gcctgtggtc     1200

ccagcacttt gggaggccga ggcaggtgga tcatgaggtc aggagatcaa gaccatcctg     1260

gctaacatgg tgaaaccccg tctacgctaa aaatacaaac agttagccgg gcgtggtggc     1320

gggtgcctgt agtcccagct acttgggagg ctgaggcagg agaatggcat gaacccagga     1380

ggcggagctt gcagtgagcc gagattgtgc cactgcactc cagcctgggc gacagagcga     1440

gaccggcccc ttctcctctc ctactctctc tttcgccatg tgacacgcct gctcctcttt     1500

tgccttccat catgagtgaa agcttcctga ggtcttgacc agaagcaatg ctggtgccat     1560

gcttcctgta cagccctcag aactgtgagc caaataaacc tctcttcttt ataaattacc     1620

cagcctcagg tattccttta tagtaatgaa atctctctgt ctcggatgaa atgcccagtc     1680

ctcattgtca acccctcatt cttcatgcta ggatttgtac ttgtgtttct gaatcagatg     1740

ttttctccat cgaatgcttt accctttgaa ccaacccagg ccttgctgat tgtagtgtga     1800

tgggtccccc accaggttac ttaagggtgt atgttcactg tctgaaccct caaggccagg     1860

cagttagtca aggccatggt gcccagctgt ggagcaggtg tccctgagaa tccaaacatc     1920

ctagaagata tctgaaaacc tactaaggaa aacagtccca tggcacatac acagtaggtg     1980

aagagccaga aaattagctt aaaagcagct tagagatgtg aggcaaagca ggtctctaga     2040

gctgtcctgc tgctgcccag gagtgcccca catggaagac ctaaataaac tcatctactc     2100

acc                                                                   2103


<210>  19
<211>  7273
<212>  DNA
<213>  Homo sapiens

<400>  19
catgtggatt ccaagcaggc taaaaagaaa aagaactgat tagacctcag acgacccact       60

aaacgggatg acggccacag ctgaggtaga gacaccaaaa atggagaaga gtgcctccaa      120

ggaagagaag cagcagccta agcaggacag cacagagcag ggcaatgctg attctgaaga      180

gtggatgagc tctgagagtg accctgaaca gataagcctt aagagtagcg acaacagcaa      240

gagctgccaa cctagggatg gtcagttgaa gaaaaaggag atgcactcca agccacaccg      300

ccagctctgt cgatcaccct gcctagatcg tccaagtttc tcccagagca gcattttaca      360

ggatggtaaa cttgacttgg agaaggaata ccaagctaag atggagtttg cgctaaagct      420

gggctatgca gaggaacaga ttcaatcagt gctaaacaag ctgggcccag aatcacttat      480

taatgatgta ttggcagagc ttgtcagact tgggaacaaa ggtgattcag aagggcagat      540

caacttgagt ctgttagtgc ctcgtgggcc cagctccaga gagattgcaa gccctgaatt      600

gtctcttgaa gatgaaatag ataacagtga caatttgagg ccagttgtca ttgatggaag      660

taatgtggca atgagccatg ggaataaaga agaattctcc tgcagaggaa tacaacttgc      720

tgtggattgg tttctagata aaggccataa agatattact gtatttgtgc ctgcatggag      780

aaaggagcaa tcccgccctg atgcaccaat tacagatcaa gatattctac gaaaactgga      840

gaaggaaaag attcttgtct tcacaccatc ccgaagagtc caaggcagga gggttgtctg      900

ctatgatgac cggttcatag tcaaactggc ttttgattct gatggcatca ttgtgtccaa      960

tgataactac cgagaccttc aagttgaaaa gccagaatgg aagaagttta tagaggagcg     1020

gttgctgatg tattcttttg tgaatgacaa atttatgcct ccagatgatc cattaggacg     1080

ccacggccca agccttgaaa atttcttaag aaagagaccc attgttcctg agcataagaa     1140

gcaaccatgt ccttatggca aaaaatgcac ctacggccac aagtgcaaat actaccatcc     1200

ggagcgggcc aaccaacccc agcgttcggt ggctgatgag ctccgcatca gtgccaaact     1260

gtccacagtg aaaactatga gtgaaggcac cctggccaag tgtggcacag ggatgtctag     1320

tgccaaaggt gagataacct cagaggtcaa acgtgtggcc cccaagcgcc aatcagatcc     1380

cagcatccgg tctgtggcta tggagcctga ggaatggctg tccattgccc gtaagcctga     1440

ggctagttct gtcccctcgc ttgtgactgc cctaagtgtt cccacaatcc caccccccaa     1500

aagccatgca gtgggtgcac tcaacacccg ttcggccagc agcccagtgc caggatcctc     1560

ccatttcccc caccagaagg cctctttgga gcatatggcc agcatgcagt atcctcccat     1620

cttggttacc aacagccatg ggacccctat tagctatgct gagcaatacc caaagtttga     1680

atccatgggg gaccatggct actattcaat gttaggtgac ttctccaaac tgaacatcaa     1740

cagcatgcat aaccgagagt attacatggc tgaagtagac cggggggtgt atgcccggaa     1800

tcctaacctc tgttctgaca gccgtgtgag ccataccagg aatgacaact attcctctta     1860

caacaacgtg tatttggctg tagctgatac ccatcctgaa ggcaatttga agctgcaccg     1920

ctcagcatcc cagaaccgac ttcagccttt tcctcatggt taccatgaag ccttaacacg     1980

agtgcagagc tatggcccag aggattctaa gcaaggcccc cacaaacagt cagtccccca     2040

cttagctctg catgcccagc acccatcaac tggaacacgt tccagctgtc ctgcagacta     2100

ccccatgcct cccaatatcc atcctggggc aaccccccag ccaggccgtg ccctggtgat     2160

gactcggatg gatagcattt ccgactcccg cctctatgag agcaaccccg tgaggcaaag     2220

acgacctccc ctgtgccggg aacagcatgc cagctgggac ccgctgccct gtacaactga     2280

ctcctatggc taccactcct atcccttgag taacagcctc atgcaaccat gttatgagcc     2340

agtcatggta cggagcgtgc ctgaaaagat ggagcagctt tggaggaatc cttgggttgg     2400

aatgtgcaat gattccaggg agcatatgat cccagaacac cagtatcaga cctacaagaa     2460

cctctgcaat attttccctt ctaacatcgt ccttgcagtg atggagaaga atccccacac     2520

agcagatgcc cagcaactgg cagccttgat tgttgctaag cttagggctg cacgttgata     2580

tgacatagta cttatttctt tatacaaata tgaatattaa tactaataat acactaatac     2640

aataattata gtaactaata atttgtgttg cgctttacaa gttagagtgt ttatatcatt     2700

taagcgctta acaaccctgt gaggtacgtc ttactaacat cctcttttat agagaaggaa     2760

ggtgaaggtc agtgaaatta agtggctagc cagggtcaca ctgctagcaa atgactaagt     2820

caagacacac acccaagtcc tctaaatcca agtcccatgc ccctttgcac tgcaccatgc     2880

aggtaatgga ggacaaaacc cagggggaga ggtctagatg taagaaatcc cagaggattc     2940

cattaccaga gttttccttt ttctcttttc gtttctttct ttctttcttt attttttttt     3000

tttgagacag aatctcactc tgttacacag gctggagtgc agtggcacta tctctgctca     3060

ctgcaacctc cacctccagg gttcaagtga ttctatggcc tcagcctccc aggtagctgg     3120

gattacaggc gtgcaccacc atgcccagct aatttttgta tttttagtag agacgtggtt     3180

tcaccgtgtt ggccaggctg gtctcaaact cctggcctca agtgatccgc ccaccttggc     3240

ctcctaaagt gctgggatta caggtgtgag ccactgcgcc cagcctacca gagttttcgt     3300

agtcacatat tctatattac aaagtatgga tgatatatcc aatttagaga gcaaaagcat     3360

caggatcaga tcatatgttg aattaacctt ttaggttttt tctaatagaa atatttaaag     3420

ctatttaaaa gtaaatgcat actttattgc atggatatct gatcactcaa tctatattaa     3480

tgaaactata gggtcacatt gaagcttcta gaactatatt ttaaagctat tattagcaat     3540

tatattgcat gtatgaatat atatatttgg tttgagatgt gtgtgtatct ctgtataacc     3600

ttttatatag tgataatgag agggtaggct ctacacagtc cttcgtctat agctgtatag     3660

gtcactaatc tgacttgatg attttaagtc acatttcata gttttaacta gttatgagag     3720

agaaattata tggcaatatt tgaacattgc tttcttaggc accagagcaa agcaactctg     3780

tttcctttgc acattttacc tgccaacatt tattaacagt tcttaccttc caagtctctt     3840

caccttagca aattagggat caggttgcag tcttctgcag agaaactgat ggttaagctc     3900

aagttccaag catagtatgt gtgtgctaca caagctcaga agagtttgac aaggaccagg     3960

ggacttacta ccacaatcca cttcccttat cccaggagag atggccaaac ccatgtggca     4020

ttaaatggtg aataaaaaag cttcactcaa ggagggacta ttggatgctc tttggacttc     4080

tgacctatgc agtattcaac atcattggat gaaatgtaat ggaggacagt gcacagccat     4140

gtatccactt tctcttcctg tccacccttt gggtaataag gtcaatcatt ggtggaacag     4200

aatttctcta ggaaacaaaa ccaggggatt ttatttgtgg aaaaaggaag tttccaaaag     4260

gggatactgc atctttacta atagctggct cagttactca ctttaaatcc atgcaaagag     4320

tgcacttgct gttaaataat tgttaaatga gttattagaa ggcaggactt ttggtttggg     4380

cgacaccatt tgcgcaactt gtatcttgct cagggtggaa aacttcatag ctaaatgcct     4440

ctagaagagg tgtttattgt tttttttaag ctgcactaaa tgaattccct ttttgaatcc     4500

attgtatatt tcaatatttc gaaccatgat cagctcacta tttcctgagc tggaacttgc     4560

taacttctat gatcgttttt tcatgaaagt tgagaaggcc gggccttggc cttttgtttc     4620

ttcatgagaa ggtgtgacac tgcctataaa tgtttcttac tgtgaaacac tctgaatgtg     4680

aggctgtagt cagggttgtt tctggtggtt tgacaatggc ttgcatgctg ctttctggct     4740

ttctgtctct gtccaagttg atcaatactg catcttaacc aatgtttcac ttgagttaac     4800

cacagcttta cattctatct cctatcttct gatcttcgta taccccagca tattgaaaaa     4860

gagtaaaagt attttctatc aatcaggtag atccacagag tgacagttgc cactgcagtg     4920

cttgctattt cacacaaaca ccatttcata ccttcaactt cttggacttt ctaaatcgga     4980

ctcgtgtcta aatcagggta tttgacaatc tcagatgatg ctactgccta tgtgccagtt     5040

agttcatctt cctaccaaga tcatgaatgg caccacacta tccactagct gtacaattta     5100

cagagaagca caagattcat cttgtcacct acaattcgtc ttgaacatgt tcatatttag     5160

tactcagaaa ctgtgtaagc tcctcccaat acagaaaata ttttttaagg cagcatatgt     5220

atttctgatt tactaaaaac gattgtcatt ctcctctcat tcttcttttt ggtatgaacc     5280

aaaagcggct aggagcaatg cctcaaataa ccagaaatga ccttttgttg atacaaattg     5340

tatctctttt tttcctgatt gtatagaaac aaatgtacaa aactcatctg aagctaggtt     5400

tggcactgaa ttttcaccat gaggtttgtg gcactgtgtg tcacagggaa gtagctcagg     5460

ggttgtgagg gagcttttat ttctaaaggg cagtagtaat ttatagacaa aaacaatttt     5520

tcaaggcctc tttattacca ctgcacagct atcatgtgta aaatttcaag cattatattg     5580

cataagttct ctttagccta ttaaatttaa tatgtccttg caaaagggat tttgtgtaaa     5640

aagtgtcagt gttagtgact catctgcaag aatctacaaa tggagctata caactatgaa     5700

tacataaata cagcatggtt cctagttatt agagaaacat tttctttata ttgaggtcta     5760

cgcacttctt gactttccat tttgtctgta attataaaac agcaaataac aaagaagcat     5820

tgggaccccc tcggctgcct tgataataaa atcaagcttc cttcatggga ctaagcatgt     5880

gtccttcagg atacttacct ctaagcactc agcaggggtt actacaaagc gttttgtgtg     5940

gttttcaaaa aacagtgtat tttgcaagag gtgctttgta attttaatta tttcactgat     6000

tttctgacct cataggaagt ctgtgcctgt tgaggccttc aattttgtag cttttctgat     6060

tttttttctt ctttttgtga ttttgttgtt gttttcattt tgatctaaag gagaagtgtg     6120

accccggagt ggcatggtca atccagggca ccctttctgt aagacaactc aaaggaaaag     6180

aagccttttc aaaggtaata tcgagccatt gcactctctc ttaaggtgcc aggtatggga     6240

gaatgacaga tgccttatgg aaatggtcta caaaactttt cttcttctaa gtaataaaac     6300

acatagcatg attctctctc cctctctctc tctctctctg cccaccccct gctagtttcc     6360

aggagaatac ttctctaaaa ttcatttttt tctattttgg aataaattat ctttatacag     6420

taattcaaac actgatttcc attaaccttt ggccctgagt tttcttctaa catagaagag     6480

ttcattttga gaggcactca gttaccattc aatctgtgct gtaagtatgg gactttgtac     6540

aaatgccctt tttgagggcc aaaaatttca atacactttg ttctactttg tgaaccaggt     6600

ctggatctgc acagagaaag taatgctgag ctgtccaaag agtccgctca ggtctccctc     6660

ctaaccctcc tctgccttcc cctagtttgc ttatcctcac gtctgacact gaggagtgca     6720

tagtcttcaa ctgaaatggc actacagtta gttctcattg gaaacaaaca agtgtatttc     6780

tggaacctgc tcgtctaaaa tagtcaatgc ctttgtaaag actcagcata ttcaatatct     6840

attgtatggt agctagctat atacatagat tgactatttt tagtcctggt ttgtgtattg     6900

ttgagctata gtagtttgct ttatccattt gtgggattaa acaatactgt ttaatggttg     6960

taaactttta taaaatctct ttgggttttt tgtttgaccc aaacataatg taagtcttaa     7020

tgacaaaata cacaaagtta accagaggtg agtgaaaata tagcccttcc ccagttttgt     7080

ctgcccctat aatgcacgtg cattgctttg taatatgctc tcgctagcat gaatgtgcta     7140

tgactacttc atgaggtttt gtttcaccta taattgtgat ggaaaatgct gtattgctga     7200

caacaatgaa ctgtaaccac agttatttac tgcataaact atttgtgtac taaccaaaaa     7260

aaaaaaaaaa aaa                                                        7273


<210>  20
<211>  836
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Thr Ala Thr Ala Glu Val Glu Thr Pro Lys Met Glu Lys Ser Ala 
1               5                   10                  15      


Ser Lys Glu Glu Lys Gln Gln Pro Lys Gln Asp Ser Thr Glu Gln Gly 
            20                  25                  30          


Asn Ala Asp Ser Glu Glu Trp Met Ser Ser Glu Ser Asp Pro Glu Gln 
        35                  40                  45              


Ile Ser Leu Lys Ser Ser Asp Asn Ser Lys Ser Cys Gln Pro Arg Asp 
    50                  55                  60                  


Gly Gln Leu Lys Lys Lys Glu Met His Ser Lys Pro His Arg Gln Leu 
65                  70                  75                  80  


Cys Arg Ser Pro Cys Leu Asp Arg Pro Ser Phe Ser Gln Ser Ser Ile 
                85                  90                  95      


Leu Gln Asp Gly Lys Leu Asp Leu Glu Lys Glu Tyr Gln Ala Lys Met 
            100                 105                 110         


Glu Phe Ala Leu Lys Leu Gly Tyr Ala Glu Glu Gln Ile Gln Ser Val 
        115                 120                 125             


Leu Asn Lys Leu Gly Pro Glu Ser Leu Ile Asn Asp Val Leu Ala Glu 
    130                 135                 140                 


Leu Val Arg Leu Gly Asn Lys Gly Asp Ser Glu Gly Gln Ile Asn Leu 
145                 150                 155                 160 


Ser Leu Leu Val Pro Arg Gly Pro Ser Ser Arg Glu Ile Ala Ser Pro 
                165                 170                 175     


Glu Leu Ser Leu Glu Asp Glu Ile Asp Asn Ser Asp Asn Leu Arg Pro 
            180                 185                 190         


Val Val Ile Asp Gly Ser Asn Val Ala Met Ser His Gly Asn Lys Glu 
        195                 200                 205             


Glu Phe Ser Cys Arg Gly Ile Gln Leu Ala Val Asp Trp Phe Leu Asp 
    210                 215                 220                 


Lys Gly His Lys Asp Ile Thr Val Phe Val Pro Ala Trp Arg Lys Glu 
225                 230                 235                 240 


Gln Ser Arg Pro Asp Ala Pro Ile Thr Asp Gln Asp Ile Leu Arg Lys 
                245                 250                 255     


Leu Glu Lys Glu Lys Ile Leu Val Phe Thr Pro Ser Arg Arg Val Gln 
            260                 265                 270         


Gly Arg Arg Val Val Cys Tyr Asp Asp Arg Phe Ile Val Lys Leu Ala 
        275                 280                 285             


Phe Asp Ser Asp Gly Ile Ile Val Ser Asn Asp Asn Tyr Arg Asp Leu 
    290                 295                 300                 


Gln Val Glu Lys Pro Glu Trp Lys Lys Phe Ile Glu Glu Arg Leu Leu 
305                 310                 315                 320 


Met Tyr Ser Phe Val Asn Asp Lys Phe Met Pro Pro Asp Asp Pro Leu 
                325                 330                 335     


Gly Arg His Gly Pro Ser Leu Glu Asn Phe Leu Arg Lys Arg Pro Ile 
            340                 345                 350         


Val Pro Glu His Lys Lys Gln Pro Cys Pro Tyr Gly Lys Lys Cys Thr 
        355                 360                 365             


Tyr Gly His Lys Cys Lys Tyr Tyr His Pro Glu Arg Ala Asn Gln Pro 
    370                 375                 380                 


Gln Arg Ser Val Ala Asp Glu Leu Arg Ile Ser Ala Lys Leu Ser Thr 
385                 390                 395                 400 


Val Lys Thr Met Ser Glu Gly Thr Leu Ala Lys Cys Gly Thr Gly Met 
                405                 410                 415     


Ser Ser Ala Lys Gly Glu Ile Thr Ser Glu Val Lys Arg Val Ala Pro 
            420                 425                 430         


Lys Arg Gln Ser Asp Pro Ser Ile Arg Ser Val Ala Met Glu Pro Glu 
        435                 440                 445             


Glu Trp Leu Ser Ile Ala Arg Lys Pro Glu Ala Ser Ser Val Pro Ser 
    450                 455                 460                 


Leu Val Thr Ala Leu Ser Val Pro Thr Ile Pro Pro Pro Lys Ser His 
465                 470                 475                 480 


Ala Val Gly Ala Leu Asn Thr Arg Ser Ala Ser Ser Pro Val Pro Gly 
                485                 490                 495     


Ser Ser His Phe Pro His Gln Lys Ala Ser Leu Glu His Met Ala Ser 
            500                 505                 510         


Met Gln Tyr Pro Pro Ile Leu Val Thr Asn Ser His Gly Thr Pro Ile 
        515                 520                 525             


Ser Tyr Ala Glu Gln Tyr Pro Lys Phe Glu Ser Met Gly Asp His Gly 
    530                 535                 540                 


Tyr Tyr Ser Met Leu Gly Asp Phe Ser Lys Leu Asn Ile Asn Ser Met 
545                 550                 555                 560 


His Asn Arg Glu Tyr Tyr Met Ala Glu Val Asp Arg Gly Val Tyr Ala 
                565                 570                 575     


Arg Asn Pro Asn Leu Cys Ser Asp Ser Arg Val Ser His Thr Arg Asn 
            580                 585                 590         


Asp Asn Tyr Ser Ser Tyr Asn Asn Val Tyr Leu Ala Val Ala Asp Thr 
        595                 600                 605             


His Pro Glu Gly Asn Leu Lys Leu His Arg Ser Ala Ser Gln Asn Arg 
    610                 615                 620                 


Leu Gln Pro Phe Pro His Gly Tyr His Glu Ala Leu Thr Arg Val Gln 
625                 630                 635                 640 


Ser Tyr Gly Pro Glu Asp Ser Lys Gln Gly Pro His Lys Gln Ser Val 
                645                 650                 655     


Pro His Leu Ala Leu His Ala Gln His Pro Ser Thr Gly Thr Arg Ser 
            660                 665                 670         


Ser Cys Pro Ala Asp Tyr Pro Met Pro Pro Asn Ile His Pro Gly Ala 
        675                 680                 685             


Thr Pro Gln Pro Gly Arg Ala Leu Val Met Thr Arg Met Asp Ser Ile 
    690                 695                 700                 


Ser Asp Ser Arg Leu Tyr Glu Ser Asn Pro Val Arg Gln Arg Arg Pro 
705                 710                 715                 720 


Pro Leu Cys Arg Glu Gln His Ala Ser Trp Asp Pro Leu Pro Cys Thr 
                725                 730                 735     


Thr Asp Ser Tyr Gly Tyr His Ser Tyr Pro Leu Ser Asn Ser Leu Met 
            740                 745                 750         


Gln Pro Cys Tyr Glu Pro Val Met Val Arg Ser Val Pro Glu Lys Met 
        755                 760                 765             


Glu Gln Leu Trp Arg Asn Pro Trp Val Gly Met Cys Asn Asp Ser Arg 
    770                 775                 780                 


Glu His Met Ile Pro Glu His Gln Tyr Gln Thr Tyr Lys Asn Leu Cys 
785                 790                 795                 800 


Asn Ile Phe Pro Ser Asn Ile Val Leu Ala Val Met Glu Lys Asn Pro 
                805                 810                 815     


His Thr Ala Asp Ala Gln Gln Leu Ala Ala Leu Ile Val Ala Lys Leu 
            820                 825                 830         


Arg Ala Ala Arg 
        835     


<210>  21
<211>  1305
<212>  DNA
<213>  Homo sapiens

<400>  21
gcgcggccgg ttactcgctt accggaggct tcagtccccg gcggcgcggc gacagctagg       60

gttcacggcc actggggcag aggagccgcg agaagatgtg ggtttttggt tacgggtccc      120

tgatctggaa ggtggatttc ccctatcagg acaagctggt cggatacatc accaactaca      180

gcaggcgctt ctggcagggc agcacggacc accgcggggt ccccggcaag cctggaagag      240

ttgtgactct tgttgaagat cctgcgggat gtgtatgggg tgttgcttac agattgccag      300

taggaaagga agaagaagta aaagcatacc ttgacttcag agaaaaagga ggctacagaa      360

ccacaacagt cattttttat ccaaaagatc ccacaacaaa accattcagt gtattgctat      420

atattggaac atgtgataat cctgattatc ttggtcctgc acctctggaa gacattgctg      480

aacaaatttt taatgcagct ggtccaagtg gaagaaatac agaatatctt tttgaacttg      540

caaattctat taggaacctt gtgccagaag aagcagatga gcatcttttc gctttggaaa      600

aattagtaaa ggaacgttta gaagggaaac agaacctcaa ttgcatataa tttagtcttc      660

agagaattaa cttcagtgca caatgacaat atgatttgga aatacgttta cttaaagatc      720

ttatttttaa tgtagtgagg atattattta aacttttatt ttaactggaa atgtcctgaa      780

acacatattt aaaatattgg gatacagtga aagaaaaatt caaattttaa taacataaag      840

atttcctaac tttatgttat tgaacactta ctcactagaa gtgagttctt tagaaaaata      900

cagtgaagga ctcagttcag tcttgttttt atcagagtga taatcatcct gtttcacatc      960

ccaatactat tttgaaattc taaacaatta aaccaaaatt ccaataaata taaggttatg     1020

ccttcaatat attcctatac aattctgtaa ccatggttta aaatacacaa gcttaaaata     1080

acatgcttag aaatacacaa taatatgaac agtatttcag ccttaattgt gaatttcctt     1140

gttattcaag tattaaatga aatcttttga gtttttagcc aaaaattggc atttttaaaa     1200

tacgaaaatt tccttggaat tataatgtac tgtacctctt cttttttaaa taaaggcatt     1260

ttactatatg gaaaactaaa aaaaaaaaaa aaaaaaaaaa aaaaa                     1305


<210>  22
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Trp Val Phe Gly Tyr Gly Ser Leu Ile Trp Lys Val Asp Phe Pro 
1               5                   10                  15      


Tyr Gln Asp Lys Leu Val Gly Tyr Ile Thr Asn Tyr Ser Arg Arg Phe 
            20                  25                  30          


Trp Gln Gly Ser Thr Asp His Arg Gly Val Pro Gly Lys Pro Gly Arg 
        35                  40                  45              


Val Val Thr Leu Val Glu Asp Pro Ala Gly Cys Val Trp Gly Val Ala 
    50                  55                  60                  


Tyr Arg Leu Pro Val Gly Lys Glu Glu Glu Val Lys Ala Tyr Leu Asp 
65                  70                  75                  80  


Phe Arg Glu Lys Gly Gly Tyr Arg Thr Thr Thr Val Ile Phe Tyr Pro 
                85                  90                  95      


Lys Asp Pro Thr Thr Lys Pro Phe Ser Val Leu Leu Tyr Ile Gly Thr 
            100                 105                 110         


Cys Asp Asn Pro Asp Tyr Leu Gly Pro Ala Pro Leu Glu Asp Ile Ala 
        115                 120                 125             


Glu Gln Ile Phe Asn Ala Ala Gly Pro Ser Gly Arg Asn Thr Glu Tyr 
    130                 135                 140                 


Leu Phe Glu Leu Ala Asn Ser Ile Arg Asn Leu Val Pro Glu Glu Ala 
145                 150                 155                 160 


Asp Glu His Leu Phe Ala Leu Glu Lys Leu Val Lys Glu Arg Leu Glu 
                165                 170                 175     


Gly Lys Gln Asn Leu Asn Cys Ile 
            180                 


<210>  23
<211>  2930
<212>  DNA
<213>  Homo sapiens

<400>  23
agcagacgag ggcttgtgcg agagggggcc gggcggctgc agggaaggcg gagtccaagg       60

ggaaaacgaa actgagaacc agctctcccg aagccgcggg tctccggccg gcggcggcgg      120

cggcggcggc ggcggcgcag tttgctcata ctttgtgact tgcggtcaca gtggcattca      180

gctccacact tggtagaacc acaggcacga caagcataga aacatcctaa acaatcttca      240

tcgaggcatc gaggtccatc ccaataaaaa tcaggagacc ctggctatca tagaccttag      300

tcttcgctgg tatcactcgt ctgtctgaac cagcggttgc atttttttaa gccttctttt      360

ttctctttta ccagtttctg gagcaaattc agtttgcctt cctggatttg taaattgtaa      420

tgacctcaaa actttagcag ttcttccatc tgactcaggt ttgcttctct ggcggtcttc      480

agaatcaaca tccacacttc cgtgattatc tgcgtgcatt ttggacaaag cttccaacca      540

ggatacggga agaagaaatg gctggtgatc tttcagcagg tttcttcatg gaggaactta      600

atacataccg tcagaagcag ggagtagtac ttaaatatca agaactgcct aattcaggac      660

ctccacatga taggaggttt acatttcaag ttataataga tggaagagaa tttccagaag      720

gtgaaggtag atcaaagaag gaagcaaaaa atgccgcagc caaattagct gttgagatac      780

ttaataagga aaagaaggca gttagtcctt tattattgac aacaacgaat tcttcagaag      840

gattatccat ggggaattac ataggcctta tcaatagaat tgcccagaag aaaagactaa      900

ctgtaaatta tgaacagtgt gcatcggggg tgcatgggcc agaaggattt cattataaat      960

gcaaaatggg acagaaagaa tatagtattg gtacaggttc tactaaacag gaagcaaaac     1020

aattggccgc taaacttgca tatcttcaga tattatcaga agaaacctca gtgaaatctg     1080

actacctgtc ctctggttct tttgctacta cgtgtgagtc ccaaagcaac tctttagtga     1140

ccagcacact cgcttctgaa tcatcatctg aaggtgactt ctcagcagat acatcagaga     1200

taaattctaa cagtgacagt ttaaacagtt cttcgttgct tatgaatggt ctcagaaata     1260

atcaaaggaa ggcaaaaaga tctttggcac ccagatttga ccttcctgac atgaaagaaa     1320

caaagtatac tgtggacaag aggtttggca tggattttaa agaaatagaa ttaattggct     1380

caggtggatt tggccaagtt ttcaaagcaa aacacagaat tgacggaaag acttacgtta     1440

ttaaacgtgt taaatataat aacgagaagg cggagcgtga agtaaaagca ttggcaaaac     1500

ttgatcatgt aaatattgtt cactacaatg gctgttggga tggatttgat tatgatcctg     1560

agaccagtga tgattctctt gagagcagtg attatgatcc tgagaacagc aaaaatagtt     1620

caaggtcaaa gactaagtgc cttttcatcc aaatggaatt ctgtgataaa gggaccttgg     1680

aacaatggat tgaaaaaaga agaggcgaga aactagacaa agttttggct ttggaactct     1740

ttgaacaaat aacaaaaggg gtggattata tacattcaaa aaaattaatt catagagatc     1800

ttaagccaag taatatattc ttagtagata caaaacaagt aaagattgga gactttggac     1860

ttgtaacatc tctgaaaaat gatggaaagc gaacaaggag taagggaact ttgcgataca     1920

tgagcccaga acagatttct tcgcaagact atggaaagga agtggacctc tacgctttgg     1980

ggctaattct tgctgaactt cttcatgtat gtgacactgc ttttgaaaca tcaaagtttt     2040

tcacagacct acgggatggc atcatctcag atatatttga taaaaaagaa aaaactcttc     2100

tacagaaatt actctcaaag aaacctgagg atcgacctaa cacatctgaa atactaagga     2160

ccttgactgt gtggaagaaa agcccagaga aaaatgaacg acacacatgt tagagccctt     2220

ctgaaaaagt atcctgcttc tgatatgcag ttttccttaa attatctaaa atctgctagg     2280

gaatatcaat agatatttac cttttatttt aatgtttcct ttaatttttt actattttta     2340

ctaatctttc tgcagaaaca gaaaggtttt cttctttttg cttcaaaaac attcttacat     2400

tttacttttt cctggctcat ctctttattc tttttttttt tttaaagaca gagtctcgct     2460

ctgttgccca ggctggagtg caatgacaca gtcttggctc actgcaactt ctgcctcttg     2520

ggttcaagtg attctcctgc ctcagcctcc tgagtagctg gattacaggc atgtgccacc     2580

cacccaacta atttttgtgt ttttaataaa gacagggttt caccatgttg gccaggctgg     2640

tctcaaactc ctgacctcaa gtaatccacc tgcctcggcc tcccaaagtg ctgggattac     2700

agggatgagc caccgcgccc agcctcatct ctttgttcta aagatggaaa aaccaccccc     2760

aaattttctt tttatactat taatgaatca atcaattcat atctatttat taaatttcta     2820

ccgcttttag gccaaaaaaa tgtaagatcg ttctctgcct cacatagctt acaagccagc     2880

tggagaaata tggtactcat taaaaaaaaa aaaaaaagtg atgtacaacc                2930


<210>  24
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Gly Asp Leu Ser Ala Gly Phe Phe Met Glu Glu Leu Asn Thr 
1               5                   10                  15      


Tyr Arg Gln Lys Gln Gly Val Val Leu Lys Tyr Gln Glu Leu Pro Asn 
            20                  25                  30          


Ser Gly Pro Pro His Asp Arg Arg Phe Thr Phe Gln Val Ile Ile Asp 
        35                  40                  45              


Gly Arg Glu Phe Pro Glu Gly Glu Gly Arg Ser Lys Lys Glu Ala Lys 
    50                  55                  60                  


Asn Ala Ala Ala Lys Leu Ala Val Glu Ile Leu Asn Lys Glu Lys Lys 
65                  70                  75                  80  


Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn Ser Ser Glu Gly Leu 
                85                  90                  95      


Ser Met Gly Asn Tyr Ile Gly Leu Ile Asn Arg Ile Ala Gln Lys Lys 
            100                 105                 110         


Arg Leu Thr Val Asn Tyr Glu Gln Cys Ala Ser Gly Val His Gly Pro 
        115                 120                 125             


Glu Gly Phe His Tyr Lys Cys Lys Met Gly Gln Lys Glu Tyr Ser Ile 
    130                 135                 140                 


Gly Thr Gly Ser Thr Lys Gln Glu Ala Lys Gln Leu Ala Ala Lys Leu 
145                 150                 155                 160 


Ala Tyr Leu Gln Ile Leu Ser Glu Glu Thr Ser Val Lys Ser Asp Tyr 
                165                 170                 175     


Leu Ser Ser Gly Ser Phe Ala Thr Thr Cys Glu Ser Gln Ser Asn Ser 
            180                 185                 190         


Leu Val Thr Ser Thr Leu Ala Ser Glu Ser Ser Ser Glu Gly Asp Phe 
        195                 200                 205             


Ser Ala Asp Thr Ser Glu Ile Asn Ser Asn Ser Asp Ser Leu Asn Ser 
    210                 215                 220                 


Ser Ser Leu Leu Met Asn Gly Leu Arg Asn Asn Gln Arg Lys Ala Lys 
225                 230                 235                 240 


Arg Ser Leu Ala Pro Arg Phe Asp Leu Pro Asp Met Lys Glu Thr Lys 
                245                 250                 255     


Tyr Thr Val Asp Lys Arg Phe Gly Met Asp Phe Lys Glu Ile Glu Leu 
            260                 265                 270         


Ile Gly Ser Gly Gly Phe Gly Gln Val Phe Lys Ala Lys His Arg Ile 
        275                 280                 285             


Asp Gly Lys Thr Tyr Val Ile Lys Arg Val Lys Tyr Asn Asn Glu Lys 
    290                 295                 300                 


Ala Glu Arg Glu Val Lys Ala Leu Ala Lys Leu Asp His Val Asn Ile 
305                 310                 315                 320 


Val His Tyr Asn Gly Cys Trp Asp Gly Phe Asp Tyr Asp Pro Glu Thr 
                325                 330                 335     


Ser Asp Asp Ser Leu Glu Ser Ser Asp Tyr Asp Pro Glu Asn Ser Lys 
            340                 345                 350         


Asn Ser Ser Arg Ser Lys Thr Lys Cys Leu Phe Ile Gln Met Glu Phe 
        355                 360                 365             


Cys Asp Lys Gly Thr Leu Glu Gln Trp Ile Glu Lys Arg Arg Gly Glu 
    370                 375                 380                 


Lys Leu Asp Lys Val Leu Ala Leu Glu Leu Phe Glu Gln Ile Thr Lys 
385                 390                 395                 400 


Gly Val Asp Tyr Ile His Ser Lys Lys Leu Ile His Arg Asp Leu Lys 
                405                 410                 415     


Pro Ser Asn Ile Phe Leu Val Asp Thr Lys Gln Val Lys Ile Gly Asp 
            420                 425                 430         


Phe Gly Leu Val Thr Ser Leu Lys Asn Asp Gly Lys Arg Thr Arg Ser 
        435                 440                 445             


Lys Gly Thr Leu Arg Tyr Met Ser Pro Glu Gln Ile Ser Ser Gln Asp 
    450                 455                 460                 


Tyr Gly Lys Glu Val Asp Leu Tyr Ala Leu Gly Leu Ile Leu Ala Glu 
465                 470                 475                 480 


Leu Leu His Val Cys Asp Thr Ala Phe Glu Thr Ser Lys Phe Phe Thr 
                485                 490                 495     


Asp Leu Arg Asp Gly Ile Ile Ser Asp Ile Phe Asp Lys Lys Glu Lys 
            500                 505                 510         


Thr Leu Leu Gln Lys Leu Leu Ser Lys Lys Pro Glu Asp Arg Pro Asn 
        515                 520                 525             


Thr Ser Glu Ile Leu Arg Thr Leu Thr Val Trp Lys Lys Ser Pro Glu 
    530                 535                 540                 


Lys Asn Glu Arg His Thr Cys 
545                 550     


<210>  25
<211>  2661
<212>  DNA
<213>  Homo sapiens

<400>  25
atggagcctg caggggagcg ctttcccgaa caaaggcaag tcctgattct ccttctttta       60

ctggaagtga ctctggcagg ctgggaaccc cgtcgctatt ctgtgatgga ggaaacagag      120

agaggttctt ttgtagccaa cctggccaat gacctagggc tgggagtggg ggagctagcc      180

gagcggggag cccgggtagt ttctgaggat aacgaacaag gcttgcagct tgatctgcag      240

accgggcagt tgatattaaa tgagaagctg gaccgggaga agctgtgtgg ccctactgag      300

ccctgtataa tgcatttcca agtgttactg aaaaaacctt tggaagtatt tcgagctgaa      360

ctactagtga cagacataaa cgatcattct cctgagtttc ctgaaagaga aatgaccctg      420

aaaatcccag aaactagctc ccttgggact gtgtttcctc tgaaaaaagc tcgggacttg      480

gacgtgggca gcaataatgt tcaaaactac aatatttctc ccaattctca tttccatgtt      540

tccactcgca cccgagggga tggcaggaaa tacccagagc tggtgctgga cacagaactg      600

gatcgcgagg agcaggccga gctcagatta accttgacag cggtggacgg tggctctcca      660

ccccgatctg gcaccgtcca gatcctcatc ttggtcttgg acgccaatga caatgccccg      720

gagtttgtgc aggcgctcta cgaggtgcag gtcccagaga acagcccagt aggctcccta      780

gttgtcaagg tctctgctag ggatttagac actgggacaa atggagagat atcatactcc      840

ctttattaca gctctcagga gatagacaaa ccttttgagc taagcagcct ttcaggagaa      900

attcgactaa ttaaaaaact agattttgag acaatgtctt cgtatgatct agatatagag      960

gcatctgatg gcgggggact ttctggaaaa tgctctgtct ctgttaaggt gctggatgtt     1020

aacgataact tcccggaact aagtatttca tcacttacca gccctattcc cgagaattct     1080

ccagagacag aagtggccct gtttaggatt agagaccgag actctgggga aaatggaaaa     1140

atgatttgct caattcagga tgatgttcct tttaagctaa aaccttctgt tgagaatttc     1200

tacaggctgg taacagaagg ggcgctggac agagagacca gagccgagta caacatcacc     1260

atcaccatca cagacttggg gactccaagg ctgaaaaccg agcagagcat aaccgtgctg     1320

gtgtcggacg tcaatgacaa cgcccccgcc ttcacccaaa cctcctacac cctgttcgtc     1380

cgcgagaaca acagccccgc cctgcacatc ggcagtgtca gcgccacaga cagagactcg     1440

ggcaccaacg cccaggtcac ctactcgctg ctgccgcccc gggacccgca cctgcccctc     1500

acctccctgg tctccattaa cacggacaac ggccacctgt tcgctctcca gtcgctggac     1560

tacgaggccc tgcaggcttt cgagttccgc gtgggcgcca cagaccgcgg cttcccggcg     1620

ctgagcagcg aggcgctggt gcgagtgctg gtgctggacg ccaacgacaa ctcgcccttc     1680

gtgctgtacc cgctgcagaa cggctccgcg ccctgcaccg agctggtgcc ccgggcggcc     1740

gagccgggct acctggtgac caaggtggtg gcggtggacg gcgactcggg ccagaacgcc     1800

tggctgtcgt accagctgct caaggccacg gagcccgggc tgttcggcgt gtgggcgcac     1860

aatggcgagg tgcgcaccgc caggctgctg agcgagcgcg acgtggccaa gcacaggcta     1920

gtggtgctgg tcaaggacaa tggcgagcct ccgcgctcgg ccaccgccac gctgcaagtg     1980

ctcctggtgg acggcttctc tcagccctac ctgccgctcc cagaggcggc cccggcccaa     2040

gcccaggccg actcgcttac cgtctacctg gtggtggcat tggcctcggt gtcttcgctc     2100

ttcctcttct cggtgttcct gttcgtggca gtgcggctgt gcaggaggag cagggcggcc     2160

tcagtgggtc gctgctcggt gcccgagggc ccctttccag ggcatctggt ggacgtgagc     2220

ggcaccggga ccctttccca gagctaccag tacgaggtgt gtctgacggg aggctctgaa     2280

agtaatgatt tcaagttctt gaagcctata ttcccaaata ttgtaagcca ggactctagg     2340

aggaaatcag aatttctaga ataatgtagg tatctgtagc tttccgaccg tctgttaatt     2400

ttgtcttcct cacttttcac cttagttttt tttaaccctt tagtaatctt gaattctact     2460

tttttttaaa tttctactgt tgtctttagt aatgttactc atttcctttg tctgattgtt     2520

agttttcaaa ttattgtatt attataaata ttttatatca ggaaagttca tatttctgaa     2580

taaattaata gtattcattc ctgaagggtg atatgaaagt taaccccacc taataaacat     2640

aactctaatt ctgaaaaaaa a                                               2661


<210>  26
<211>  787
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Glu Pro Ala Gly Glu Arg Phe Pro Glu Gln Arg Gln Val Leu Ile 
1               5                   10                  15      


Leu Leu Leu Leu Leu Glu Val Thr Leu Ala Gly Trp Glu Pro Arg Arg 
            20                  25                  30          


Tyr Ser Val Met Glu Glu Thr Glu Arg Gly Ser Phe Val Ala Asn Leu 
        35                  40                  45              


Ala Asn Asp Leu Gly Leu Gly Val Gly Glu Leu Ala Glu Arg Gly Ala 
    50                  55                  60                  


Arg Val Val Ser Glu Asp Asn Glu Gln Gly Leu Gln Leu Asp Leu Gln 
65                  70                  75                  80  


Thr Gly Gln Leu Ile Leu Asn Glu Lys Leu Asp Arg Glu Lys Leu Cys 
                85                  90                  95      


Gly Pro Thr Glu Pro Cys Ile Met His Phe Gln Val Leu Leu Lys Lys 
            100                 105                 110         


Pro Leu Glu Val Phe Arg Ala Glu Leu Leu Val Thr Asp Ile Asn Asp 
        115                 120                 125             


His Ser Pro Glu Phe Pro Glu Arg Glu Met Thr Leu Lys Ile Pro Glu 
    130                 135                 140                 


Thr Ser Ser Leu Gly Thr Val Phe Pro Leu Lys Lys Ala Arg Asp Leu 
145                 150                 155                 160 


Asp Val Gly Ser Asn Asn Val Gln Asn Tyr Asn Ile Ser Pro Asn Ser 
                165                 170                 175     


His Phe His Val Ser Thr Arg Thr Arg Gly Asp Gly Arg Lys Tyr Pro 
            180                 185                 190         


Glu Leu Val Leu Asp Thr Glu Leu Asp Arg Glu Glu Gln Ala Glu Leu 
        195                 200                 205             


Arg Leu Thr Leu Thr Ala Val Asp Gly Gly Ser Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Val Gln Ile Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Glu Phe Val Gln Ala Leu Tyr Glu Val Gln Val Pro Glu Asn Ser Pro 
                245                 250                 255     


Val Gly Ser Leu Val Val Lys Val Ser Ala Arg Asp Leu Asp Thr Gly 
            260                 265                 270         


Thr Asn Gly Glu Ile Ser Tyr Ser Leu Tyr Tyr Ser Ser Gln Glu Ile 
        275                 280                 285             


Asp Lys Pro Phe Glu Leu Ser Ser Leu Ser Gly Glu Ile Arg Leu Ile 
    290                 295                 300                 


Lys Lys Leu Asp Phe Glu Thr Met Ser Ser Tyr Asp Leu Asp Ile Glu 
305                 310                 315                 320 


Ala Ser Asp Gly Gly Gly Leu Ser Gly Lys Cys Ser Val Ser Val Lys 
                325                 330                 335     


Val Leu Asp Val Asn Asp Asn Phe Pro Glu Leu Ser Ile Ser Ser Leu 
            340                 345                 350         


Thr Ser Pro Ile Pro Glu Asn Ser Pro Glu Thr Glu Val Ala Leu Phe 
        355                 360                 365             


Arg Ile Arg Asp Arg Asp Ser Gly Glu Asn Gly Lys Met Ile Cys Ser 
    370                 375                 380                 


Ile Gln Asp Asp Val Pro Phe Lys Leu Lys Pro Ser Val Glu Asn Phe 
385                 390                 395                 400 


Tyr Arg Leu Val Thr Glu Gly Ala Leu Asp Arg Glu Thr Arg Ala Glu 
                405                 410                 415     


Tyr Asn Ile Thr Ile Thr Ile Thr Asp Leu Gly Thr Pro Arg Leu Lys 
            420                 425                 430         


Thr Glu Gln Ser Ile Thr Val Leu Val Ser Asp Val Asn Asp Asn Ala 
        435                 440                 445             


Pro Ala Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn 
    450                 455                 460                 


Ser Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser 
465                 470                 475                 480 


Gly Thr Asn Ala Gln Val Thr Tyr Ser Leu Leu Pro Pro Arg Asp Pro 
                485                 490                 495     


His Leu Pro Leu Thr Ser Leu Val Ser Ile Asn Thr Asp Asn Gly His 
            500                 505                 510         


Leu Phe Ala Leu Gln Ser Leu Asp Tyr Glu Ala Leu Gln Ala Phe Glu 
        515                 520                 525             


Phe Arg Val Gly Ala Thr Asp Arg Gly Phe Pro Ala Leu Ser Ser Glu 
    530                 535                 540                 


Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe 
545                 550                 555                 560 


Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val 
                565                 570                 575     


Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val 
            580                 585                 590         


Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys 
        595                 600                 605             


Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val 
    610                 615                 620                 


Arg Thr Ala Arg Leu Leu Ser Glu Arg Asp Val Ala Lys His Arg Leu 
625                 630                 635                 640 


Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala 
                645                 650                 655     


Thr Leu Gln Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro 
            660                 665                 670         


Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Ser Leu Thr Val 
        675                 680                 685             


Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser 
    690                 695                 700                 


Val Phe Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala 
705                 710                 715                 720 


Ser Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly His Leu 
                725                 730                 735     


Val Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln Tyr Glu 
            740                 745                 750         


Val Cys Leu Thr Gly Gly Ser Glu Ser Asn Asp Phe Lys Phe Leu Lys 
        755                 760                 765             


Pro Ile Phe Pro Asn Ile Val Ser Gln Asp Ser Arg Arg Lys Ser Glu 
    770                 775                 780                 


Phe Leu Glu 
785         


<210>  27
<211>  3725
<212>  DNA
<213>  Homo sapiens

<400>  27
acatttcaga gcagtccggg ttgtggacgc caggagtttg ccaaacacag caaacactgg       60

tgtgtgagcg gctgaagggg actctttcca ctccgatctc cctccctccc agcctgtttt      120

gatttactag gacttcctcc tccgggcgag gcgggggaag gacgccgccg agcgcctgga      180

gttgtgcgcg tgtgcgtgtg cgcgtgtgcg agtgtgaagt gcagcgctgg agtgcaacat      240

gctgtaatgg gaggaaaccc agcggcgtcg gagcgcccgg gaccgccgcg gccgttctga      300

gcgcagtggc gccgagcagc ccctcccgca gccggtgtga cctgtccctt caggctccaa      360

ccaggaatgg agacgccatt ggatgttttg tccagggcag catctctggt gcatgctgat      420

gacgaaaaac gcgaagctgc tctcagggga gaacccagaa tacagaccct gccggtggcc      480

tctgccctca gcagtcaccg caccggccct cccccaatca gccccagcaa gaggaagttc      540

agcatggagc caggtgacga ggacctagac tgtgacaacg accacgtctc caaaatgagt      600

cgcatcttca acccccatct gaacaagact gccaatggag actgccgcag agacccccgg      660

gagcggagcc gcagccccat cgagcgcgct gtggccccca ccatgagcct gcacggcagc      720

cacctgtaca cctccctccc cagccttggc ctggagcagc ccctcgcact gaccaagaac      780

agcctggacg ccagcaggcc agccggcctc tcgcccacac tgaccccggg ggagcggcag      840

cagaaccggc cctccgtgat cacctgtgcc tcggctggcg cccgcaactg caacctctcg      900

cactgcccca tcgcgcacag cggctgtgcc gcgcccgggc ctgccagcta ccggaggcca      960

ccgagcgctg ccaccacctg tgaccccgtg gtggaggagc atttccgcag gagcctgggc     1020

aagaattaca aggagcccga gccggcaccc aactccgtgt ccatcacggg ctccgtggac     1080

gaccactttg ccaaagctct gggtgacacg tggctccaga tcaaagcggc caaggacgga     1140

gcatccagca gccctgagtc cgcctctcgc aggggccagc ccgccagccc ctctgcccac     1200

atggtcagcc acagtcactc cccctctgtg gtctcctgaa gggagcgcct cctccaacaa     1260

cacgtggatc tgcatggttt gcctgagctt tgaacagtca gtacttaaaa aaaaaaaaat     1320

catgggggtg gggtgggggg aagggaaggg atggtttatt tgcaaaaacc atgttgttgg     1380

gatttgtgtt ctgtttttgt acttgcttgg tatccgtaca agggggccct caaacatgat     1440

agcaggaact acgcgtggaa catctgtcta atgtagcatc cttacttcct gcctcagtta     1500

ccaaagaaac ctctgatgca ggtctgctgc cccgacgggg ccaggactcc acagcgcttt     1560

ctcagtcaca agccatgatg aattggtgac tcagacgctt tgtgcttttt cctttgcttc     1620

ttgagaccgg ggtgtgtgtg gctcagcttc cacggcgtgt ttggttcggt ccatgtgtgt     1680

gcgtgtgtat acttgaagag aactgtcgtg tctgatttgc actattggag gaggactaaa     1740

gttgcctgac aactttatgt gttatgccag aactctgagg gcaaactgct gaaaaacaaa     1800

gggtttaagg atgacatttc tgaccatttg tgtgtttgtt gttgttactg tttttgtttt     1860

ttttaatgta gacaatacag ctttggaagg ggaagtctca tacaggttat aggtctttct     1920

ctctctagat ttcaggtgct tgcaactgga ctgcagactc taccaatcac gggcatttta     1980

tcttctctga acactgcagt ttgttagact agagctgagg ttggaggatt ccatagtgct     2040

ttaaacgtga tgcatgtttt aatggagaaa aaatagctgg tttctattaa ttatatagac     2100

agtaaacaaa aaccttaata cttactatct tcttttcaga attagtttat ttttgtcagt     2160

tacagtccta gatatactta ctgctggtac agttgtactc taagattggt atttgatatt     2220

cactttactc acaagtagtg cgggaggcca gctcctggca ggccctcgcg atgagcagtg     2280

ggtcagctgc ggtgtgggat gctggagttt ggctgcaggc tgacatcatt tatttttgca     2340

tccctgtctg ctttgttaca agctcccagg ggaggtgggg tttgtgtctt ccaacttccc     2400

tacatgcaga aactgctccc tttgaactct cttggctgaa cagcagatta ctgacagaca     2460

atctgtgata tggtgtttta tacgcttcct cgtacgctgg ggccaaggca gtatacattc     2520

ctctgacttt atactgttat tactgcattt attatttgct atattaatag ctactaacta     2580

gaaattagat gaagcaagca tgacagacac agctgtggag gtcacagctg ctcctttttg     2640

gtcaatgagc gtttctatcc cctccccctg gggtgtgctg tgtcccacct ggcccaccag     2700

aggctcacga cgatggcacc tgaccaggtg acgtgggcgt ggtcacctca cctgcaaggc     2760

tttgtggact ctgcacaccg tatgaccccc ggttttacag tttttagctg ttgaattttg     2820

gaaattggca ctgggtgaaa aggtcggagg actggctctt gtagtcacag agtggctgca     2880

ggcctttgaa aagtggagga aagaaaagcc cttctccttg ccccgcacac atttcactcc     2940

cactgtactg ggcttccaag ctttggcatt caggccccta tattttctgt aggaaaaatc     3000

gttgagaaca cttttctata tgggtgattt tgagaccatc gttacgctgt gcgtaaagaa     3060

tgtacagaga aatttgtagg tattttttga agaacattaa tttgttaatg atatgtagct     3120

atttaatttt tccctttcct attgtaatca ttcatttttt ttgttgttcg gaaaaaaaaa     3180

gttgatcttt ttttttgtcg tagatttgtc tgtaaaagtg caggaacagt tattctatga     3240

gaacactgca tctgcattca tagccacgag tttgttattg ctacaggcta ctgagcgtcg     3300

taacaggaaa accacccaca gctgaccggc tcggtggagg acactcctgg gacaggtctc     3360

tttgtcagtg aacaagggcg tcactctggg aggggtcggc ggtgctggcg gccgggtccc     3420

tggtgcactg acctatctgg gataggcagt accctggagg ggggcctggg gcagaggagg     3480

cagcagaaaa ccaaacattt cactgagaaa gccccctccc tgctctaaga aggggctccg     3540

tgaagttctt cccagagccg cgctgcctgc agtgcgctct gaccttctct tcatgtgtgt     3600

aaatctgtaa tataccattc tctgtggcct gtttttcctg gaagaagaaa aaaaaaggtt     3660

tggcaggcca tctttttttg tacttaaaag tagccttaag aacaataata aagtgctctt     3720

aaacc                                                                 3725


<210>  28
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Glu Thr Pro Leu Asp Val Leu Ser Arg Ala Ala Ser Leu Val His 
1               5                   10                  15      


Ala Asp Asp Glu Lys Arg Glu Ala Ala Leu Arg Gly Glu Pro Arg Ile 
            20                  25                  30          


Gln Thr Leu Pro Val Ala Ser Ala Leu Ser Ser His Arg Thr Gly Pro 
        35                  40                  45              


Pro Pro Ile Ser Pro Ser Lys Arg Lys Phe Ser Met Glu Pro Gly Asp 
    50                  55                  60                  


Glu Asp Leu Asp Cys Asp Asn Asp His Val Ser Lys Met Ser Arg Ile 
65                  70                  75                  80  


Phe Asn Pro His Leu Asn Lys Thr Ala Asn Gly Asp Cys Arg Arg Asp 
                85                  90                  95      


Pro Arg Glu Arg Ser Arg Ser Pro Ile Glu Arg Ala Val Ala Pro Thr 
            100                 105                 110         


Met Ser Leu His Gly Ser His Leu Tyr Thr Ser Leu Pro Ser Leu Gly 
        115                 120                 125             


Leu Glu Gln Pro Leu Ala Leu Thr Lys Asn Ser Leu Asp Ala Ser Arg 
    130                 135                 140                 


Pro Ala Gly Leu Ser Pro Thr Leu Thr Pro Gly Glu Arg Gln Gln Asn 
145                 150                 155                 160 


Arg Pro Ser Val Ile Thr Cys Ala Ser Ala Gly Ala Arg Asn Cys Asn 
                165                 170                 175     


Leu Ser His Cys Pro Ile Ala His Ser Gly Cys Ala Ala Pro Gly Pro 
            180                 185                 190         


Ala Ser Tyr Arg Arg Pro Pro Ser Ala Ala Thr Thr Cys Asp Pro Val 
        195                 200                 205             


Val Glu Glu His Phe Arg Arg Ser Leu Gly Lys Asn Tyr Lys Glu Pro 
    210                 215                 220                 


Glu Pro Ala Pro Asn Ser Val Ser Ile Thr Gly Ser Val Asp Asp His 
225                 230                 235                 240 


Phe Ala Lys Ala Leu Gly Asp Thr Trp Leu Gln Ile Lys Ala Ala Lys 
                245                 250                 255     


Asp Gly Ala Ser Ser Ser Pro Glu Ser Ala Ser Arg Arg Gly Gln Pro 
            260                 265                 270         


Ala Ser Pro Ser Ala His Met Val Ser His Ser His Ser Pro Ser Val 
        275                 280                 285             


Val Ser 
    290 


<210>  29
<211>  5053
<212>  DNA
<213>  Homo sapiens

<400>  29
tgcagacagt gcgggcctgc gcccagtccc ggctgtcctc gccgcgaccc ctcctcagcc       60

ctgggcgcgc gcacgctggg gccccgcggg gctggccgcc tagcgagcct gccggtcgac      120

cccagccagc gcagcgacgg ggcgctgcct ggcccaggcg cacacggaag tgcgcttctc      180

tgaagtagct ttggaaagta gagaagaaaa tccagtttgc ttcttggaga acactggaca      240

gctgaataaa tgcagtatct aaatataaaa gaggactgca atgccatggc tttctgtgct      300

aaaatgagga gctccaagaa gactgaggtg aacctggagg cccctgagcc aggggtggaa      360

gtgatcttct atctgtcgga cagggagccc ctccggctgg gcagtggaga gtacacagca      420

gaggaactgt gcatcagggc tgcacaggca tgccgtatct ctcctctttg tcacaacctc      480

tttgccctgt atgacgagaa caccaagctc tggtatgctc caaatcgcac catcaccgtt      540

gatgacaaga tgtccctccg gctccactac cggatgaggt tctatttcac caattggcat      600

ggaaccaacg acaatgagca gtcagtgtgg cgtcattctc caaagaagca gaaaaatggc      660

tacgagaaaa aaaagattcc agatgcaacc cctctccttg atgccagctc actggagtat      720

ctgtttgctc agggacagta tgatttggtg aaatgcctgg ctcctattcg agaccccaag      780

accgagcagg atggacatga tattgagaac gagtgtctag ggatggctgt cctggccatc      840

tcacactatg ccatgatgaa gaagatgcag ttgccagaac tgcccaagga catcagctac      900

aagcgatata ttccagaaac attgaataag tccatcagac agaggaacct tctcaccagg      960

atgcggataa ataatgtttt caaggatttc ctaaaggaat ttaacaacaa gaccatttgt     1020

gacagcagcg tgtccacgca tgacctgaag gtgaaatact tggctacctt ggaaactttg     1080

acaaaacatt acggtgctga aatatttgag acttccatgt tactgatttc atcagaaaat     1140

gagatgaatt ggtttcattc gaatgacggt ggaaacgttc tctactacga agtgatggtg     1200

actgggaatc ttggaatcca gtggaggcat aaaccaaatg ttgtttctgt tgaaaaggaa     1260

aaaaataaac tgaagcggaa aaaactggaa aataaacaca agaaggatga ggagaaaaac     1320

aagatccggg aagagtggaa caatttttct tacttccctg aaatcactca cattgtaata     1380

aaggagtctg tggtcagcat taacaagcag gacaacaaga aaatggaact gaagctctct     1440

tcccacgagg aggccttgtc ctttgtgtcc ctggtagatg gctacttccg gctcacagca     1500

gatgcccatc attacctctg caccgacgtg gcccccccgt tgatcgtcca caacatacag     1560

aatggctgtc atggtccaat ctgtacagaa tacgccatca ataaattgcg gcaagaagga     1620

agcgaggagg ggatgtacgt gctgaggtgg agctgcaccg actttgacaa catcctcatg     1680

accgtcacct gctttgagaa gtctgagcag gtgcagggtg cccagaagca gttcaagaac     1740

tttcagatcg aggtgcagaa gggccgctac agtctgcacg gttcggaccg cagcttcccc     1800

agcttgggag acctcatgag ccacctcaag aagcagatcc tgcgcacgga taacatcagc     1860

ttcatgctaa aacgctgctg ccagcccaag ccccgagaaa tctccaacct gctggtggct     1920

actaagaaag cccaggagtg gcagcccgtc taccccatga gccagctgag tttcgatcgg     1980

atcctcaaga aggatctggt gcagggcgag caccttggga gaggcacgag aacacacatc     2040

tattctggga ccctgatgga ttacaaggat gacgaaggaa cttctgaaga gaagaagata     2100

aaagtgatcc tcaaagtctt agaccccagc cacagggata tttccctggc cttcttcgag     2160

gcagccagca tgatgagaca ggtctcccac aaacacatcg tgtacctcta tggcgtctgt     2220

gtccgcgacg tggagaatat catggtggaa gagtttgtgg aagggggtcc tctggatctc     2280

ttcatgcacc ggaaaagcga tgtccttacc acaccatgga aattcaaagt tgccaaacag     2340

ctggccagtg ccctgagcta cttggaggat aaagacctgg tccatggaaa tgtgtgtact     2400

aaaaacctcc tcctggcccg tgagggcatc gacagtgagt gtggcccatt catcaagctc     2460

agtgaccccg gcatccccat tacggtgctg tctaggcaag aatgcattga acgaatccca     2520

tggattgctc ctgagtgtgt tgaggactcc aagaacctga gtgtggctgc tgacaagtgg     2580

agctttggaa ccacgctctg ggaaatctgc tacaatggcg agatcccctt gaaagacaag     2640

acgctgattg agaaagagag attctatgaa agccggtgca ggccagtgac accatcatgt     2700

aaggagctgg ctgacctcat gacccgctgc atgaactatg accccaatca gaggcctttc     2760

ttccgagcca tcatgagaga cattaataag cttgaagagc agaatccaga tattgtttca     2820

gaaaaaaaac cagcaactga agtggacccc acacattttg aaaagcgctt cctaaagagg     2880

atccgtgact tgggagaggg ccactttggg aaggttgagc tctgcaggta tgaccccgaa     2940

ggggacaata caggggagca ggtggctgtt aaatctctga agcctgagag tggaggtaac     3000

cacatagctg atctgaaaaa ggaaatcgag atcttaagga acctctatca tgagaacatt     3060

gtgaagtaca aaggaatctg cacagaagac ggaggaaatg gtattaagct catcatggaa     3120

tttctgcctt cgggaagcct taaggaatat cttccaaaga ataagaacaa aataaacctc     3180

aaacagcagc taaaatatgc cgttcagatt tgtaagggga tggactattt gggttctcgg     3240

caatacgttc accgggactt ggcagcaaga aatgtccttg ttgagagtga acaccaagtg     3300

aaaattggag acttcggttt aaccaaagca attgaaaccg ataaggagta ttacaccgtc     3360

aaggatgacc gggacagccc tgtgttttgg tatgctccag aatgtttaat gcaatctaaa     3420

ttttatattg cctctgacgt ctggtctttt ggagtcactc tgcatgagct gctgacttac     3480

tgtgattcag attctagtcc catggctttg ttcctgaaaa tgataggccc aacccatggc     3540

cagatgacag tcacaagact tgtgaatacg ttaaaagaag gaaaacgcct gccgtgccca     3600

cctaactgtc cagatgaggt ttatcaactt atgaggaaat gctgggaatt ccaaccatcc     3660

aatcggacaa gctttcagaa ccttattgaa ggatttgaag cacttttaaa ataagaagca     3720

tgaataacat ttaaattcca cagattatca agtccttctc ctgcaacaaa tgcccaagtc     3780

attttttaaa aatttctaat gaaagaagtt tgtgttctgt ccaaaaagtc actgaactca     3840

tacttcagta catatacatg tataaggcac actgtagtgc ttaatatgtg taaggacttc     3900

ctctttaaat ttggtaccag taacttagtg acacataatg acaaccaaaa tatttgaaag     3960

cacttaagca ctcctccttg tggaaagaat ataccaccat ttcatctggc tagttcacca     4020

tcacaactgc attaccaaaa ggggattttt gaaaacgagg agttgaccaa aataatatct     4080

gaagatgatt gcttttccct gctgccagct gatctgaaat gttttgctgg cacattaatc     4140

atagataaag aaagattgat ggacttagcc ctcaaatttc agtatctata cagtactaga     4200

ccatgcattc ttaaaatatt agataccagg tagtatatat tgtttctgta caaaaatgac     4260

tgtattctct caccagtagg acttaaactt tgtttctcca gtggcttagc tcctgttcct     4320

ttgggtgatc actagcaccc atttttgaga aagctggttc tacatggggg gatagctgtg     4380

gaatagataa tttgctgcat gttaattctc aagaactaag cctgtgccag tgctttccta     4440

agcagtatac ctttaatcag aactcattcc cagaacctgg atgctattac acatgctttt     4500

aagaaacgtc aatgtatatc cttttataac tctaccactt tggggcaagc tattccagca     4560

ctggttttga atgctgtatg caaccagtct gaataccaca tacgctgcac tgttcttaga     4620

gggtttccat acttaccacc gatctacaag ggttgatccc tgtttttacc atcaatcatc     4680

accctgtggt gcaacacttg aaagacccgg ctagaggcac tatggacttc aggatccact     4740

agacagtttt cagtttgctt ggaggtagct gggtaatcaa aaatgtttag tcattgattc     4800

aatgtgaacg attacggtct ttatgaccaa gagtctgaaa atctttttgt tatgctgttt     4860

agtattcgtt tgatattgtt acttttcacc tgttgagccc aaattcagga ttggttcagt     4920

ggcagcaatg aagttgccat ttaaatttgt tcatagccta catcaccaag gtctctgtgt     4980

caaacctgtg gccactctat atgcactttg tttactcttt atacaaataa atatactaaa     5040

gactttacat gca                                                        5053


<210>  30
<211>  1154
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Gln Tyr Leu Asn Ile Lys Glu Asp Cys Asn Ala Met Ala Phe Cys 
1               5                   10                  15      


Ala Lys Met Arg Ser Ser Lys Lys Thr Glu Val Asn Leu Glu Ala Pro 
            20                  25                  30          


Glu Pro Gly Val Glu Val Ile Phe Tyr Leu Ser Asp Arg Glu Pro Leu 
        35                  40                  45              


Arg Leu Gly Ser Gly Glu Tyr Thr Ala Glu Glu Leu Cys Ile Arg Ala 
    50                  55                  60                  


Ala Gln Ala Cys Arg Ile Ser Pro Leu Cys His Asn Leu Phe Ala Leu 
65                  70                  75                  80  


Tyr Asp Glu Asn Thr Lys Leu Trp Tyr Ala Pro Asn Arg Thr Ile Thr 
                85                  90                  95      


Val Asp Asp Lys Met Ser Leu Arg Leu His Tyr Arg Met Arg Phe Tyr 
            100                 105                 110         


Phe Thr Asn Trp His Gly Thr Asn Asp Asn Glu Gln Ser Val Trp Arg 
        115                 120                 125             


His Ser Pro Lys Lys Gln Lys Asn Gly Tyr Glu Lys Lys Lys Ile Pro 
    130                 135                 140                 


Asp Ala Thr Pro Leu Leu Asp Ala Ser Ser Leu Glu Tyr Leu Phe Ala 
145                 150                 155                 160 


Gln Gly Gln Tyr Asp Leu Val Lys Cys Leu Ala Pro Ile Arg Asp Pro 
                165                 170                 175     


Lys Thr Glu Gln Asp Gly His Asp Ile Glu Asn Glu Cys Leu Gly Met 
            180                 185                 190         


Ala Val Leu Ala Ile Ser His Tyr Ala Met Met Lys Lys Met Gln Leu 
        195                 200                 205             


Pro Glu Leu Pro Lys Asp Ile Ser Tyr Lys Arg Tyr Ile Pro Glu Thr 
    210                 215                 220                 


Leu Asn Lys Ser Ile Arg Gln Arg Asn Leu Leu Thr Arg Met Arg Ile 
225                 230                 235                 240 


Asn Asn Val Phe Lys Asp Phe Leu Lys Glu Phe Asn Asn Lys Thr Ile 
                245                 250                 255     


Cys Asp Ser Ser Val Ser Thr His Asp Leu Lys Val Lys Tyr Leu Ala 
            260                 265                 270         


Thr Leu Glu Thr Leu Thr Lys His Tyr Gly Ala Glu Ile Phe Glu Thr 
        275                 280                 285             


Ser Met Leu Leu Ile Ser Ser Glu Asn Glu Met Asn Trp Phe His Ser 
    290                 295                 300                 


Asn Asp Gly Gly Asn Val Leu Tyr Tyr Glu Val Met Val Thr Gly Asn 
305                 310                 315                 320 


Leu Gly Ile Gln Trp Arg His Lys Pro Asn Val Val Ser Val Glu Lys 
                325                 330                 335     


Glu Lys Asn Lys Leu Lys Arg Lys Lys Leu Glu Asn Lys His Lys Lys 
            340                 345                 350         


Asp Glu Glu Lys Asn Lys Ile Arg Glu Glu Trp Asn Asn Phe Ser Tyr 
        355                 360                 365             


Phe Pro Glu Ile Thr His Ile Val Ile Lys Glu Ser Val Val Ser Ile 
    370                 375                 380                 


Asn Lys Gln Asp Asn Lys Lys Met Glu Leu Lys Leu Ser Ser His Glu 
385                 390                 395                 400 


Glu Ala Leu Ser Phe Val Ser Leu Val Asp Gly Tyr Phe Arg Leu Thr 
                405                 410                 415     


Ala Asp Ala His His Tyr Leu Cys Thr Asp Val Ala Pro Pro Leu Ile 
            420                 425                 430         


Val His Asn Ile Gln Asn Gly Cys His Gly Pro Ile Cys Thr Glu Tyr 
        435                 440                 445             


Ala Ile Asn Lys Leu Arg Gln Glu Gly Ser Glu Glu Gly Met Tyr Val 
    450                 455                 460                 


Leu Arg Trp Ser Cys Thr Asp Phe Asp Asn Ile Leu Met Thr Val Thr 
465                 470                 475                 480 


Cys Phe Glu Lys Ser Glu Gln Val Gln Gly Ala Gln Lys Gln Phe Lys 
                485                 490                 495     


Asn Phe Gln Ile Glu Val Gln Lys Gly Arg Tyr Ser Leu His Gly Ser 
            500                 505                 510         


Asp Arg Ser Phe Pro Ser Leu Gly Asp Leu Met Ser His Leu Lys Lys 
        515                 520                 525             


Gln Ile Leu Arg Thr Asp Asn Ile Ser Phe Met Leu Lys Arg Cys Cys 
    530                 535                 540                 


Gln Pro Lys Pro Arg Glu Ile Ser Asn Leu Leu Val Ala Thr Lys Lys 
545                 550                 555                 560 


Ala Gln Glu Trp Gln Pro Val Tyr Pro Met Ser Gln Leu Ser Phe Asp 
                565                 570                 575     


Arg Ile Leu Lys Lys Asp Leu Val Gln Gly Glu His Leu Gly Arg Gly 
            580                 585                 590         


Thr Arg Thr His Ile Tyr Ser Gly Thr Leu Met Asp Tyr Lys Asp Asp 
        595                 600                 605             


Glu Gly Thr Ser Glu Glu Lys Lys Ile Lys Val Ile Leu Lys Val Leu 
    610                 615                 620                 


Asp Pro Ser His Arg Asp Ile Ser Leu Ala Phe Phe Glu Ala Ala Ser 
625                 630                 635                 640 


Met Met Arg Gln Val Ser His Lys His Ile Val Tyr Leu Tyr Gly Val 
                645                 650                 655     


Cys Val Arg Asp Val Glu Asn Ile Met Val Glu Glu Phe Val Glu Gly 
            660                 665                 670         


Gly Pro Leu Asp Leu Phe Met His Arg Lys Ser Asp Val Leu Thr Thr 
        675                 680                 685             


Pro Trp Lys Phe Lys Val Ala Lys Gln Leu Ala Ser Ala Leu Ser Tyr 
    690                 695                 700                 


Leu Glu Asp Lys Asp Leu Val His Gly Asn Val Cys Thr Lys Asn Leu 
705                 710                 715                 720 


Leu Leu Ala Arg Glu Gly Ile Asp Ser Glu Cys Gly Pro Phe Ile Lys 
                725                 730                 735     


Leu Ser Asp Pro Gly Ile Pro Ile Thr Val Leu Ser Arg Gln Glu Cys 
            740                 745                 750         


Ile Glu Arg Ile Pro Trp Ile Ala Pro Glu Cys Val Glu Asp Ser Lys 
        755                 760                 765             


Asn Leu Ser Val Ala Ala Asp Lys Trp Ser Phe Gly Thr Thr Leu Trp 
    770                 775                 780                 


Glu Ile Cys Tyr Asn Gly Glu Ile Pro Leu Lys Asp Lys Thr Leu Ile 
785                 790                 795                 800 


Glu Lys Glu Arg Phe Tyr Glu Ser Arg Cys Arg Pro Val Thr Pro Ser 
                805                 810                 815     


Cys Lys Glu Leu Ala Asp Leu Met Thr Arg Cys Met Asn Tyr Asp Pro 
            820                 825                 830         


Asn Gln Arg Pro Phe Phe Arg Ala Ile Met Arg Asp Ile Asn Lys Leu 
        835                 840                 845             


Glu Glu Gln Asn Pro Asp Ile Val Ser Glu Lys Lys Pro Ala Thr Glu 
    850                 855                 860                 


Val Asp Pro Thr His Phe Glu Lys Arg Phe Leu Lys Arg Ile Arg Asp 
865                 870                 875                 880 


Leu Gly Glu Gly His Phe Gly Lys Val Glu Leu Cys Arg Tyr Asp Pro 
                885                 890                 895     


Glu Gly Asp Asn Thr Gly Glu Gln Val Ala Val Lys Ser Leu Lys Pro 
            900                 905                 910         


Glu Ser Gly Gly Asn His Ile Ala Asp Leu Lys Lys Glu Ile Glu Ile 
        915                 920                 925             


Leu Arg Asn Leu Tyr His Glu Asn Ile Val Lys Tyr Lys Gly Ile Cys 
    930                 935                 940                 


Thr Glu Asp Gly Gly Asn Gly Ile Lys Leu Ile Met Glu Phe Leu Pro 
945                 950                 955                 960 


Ser Gly Ser Leu Lys Glu Tyr Leu Pro Lys Asn Lys Asn Lys Ile Asn 
                965                 970                 975     


Leu Lys Gln Gln Leu Lys Tyr Ala Val Gln Ile Cys Lys Gly Met Asp 
            980                 985                 990         


Tyr Leu Gly Ser Arg Gln Tyr Val  His Arg Asp Leu Ala  Ala Arg Asn 
        995                 1000                 1005             


Val Leu  Val Glu Ser Glu His  Gln Val Lys Ile Gly  Asp Phe Gly 
    1010                 1015                 1020             


Leu Thr  Lys Ala Ile Glu Thr  Asp Lys Glu Tyr Tyr  Thr Val Lys 
    1025                 1030                 1035             


Asp Asp  Arg Asp Ser Pro Val  Phe Trp Tyr Ala Pro  Glu Cys Leu 
    1040                 1045                 1050             


Met Gln  Ser Lys Phe Tyr Ile  Ala Ser Asp Val Trp  Ser Phe Gly 
    1055                 1060                 1065             


Val Thr  Leu His Glu Leu Leu  Thr Tyr Cys Asp Ser  Asp Ser Ser 
    1070                 1075                 1080             


Pro Met  Ala Leu Phe Leu Lys  Met Ile Gly Pro Thr  His Gly Gln 
    1085                 1090                 1095             


Met Thr  Val Thr Arg Leu Val  Asn Thr Leu Lys Glu  Gly Lys Arg 
    1100                 1105                 1110             


Leu Pro  Cys Pro Pro Asn Cys  Pro Asp Glu Val Tyr  Gln Leu Met 
    1115                 1120                 1125             


Arg Lys  Cys Trp Glu Phe Gln  Pro Ser Asn Arg Thr  Ser Phe Gln 
    1130                 1135                 1140             


Asn Leu  Ile Glu Gly Phe Glu  Ala Leu Leu Lys 
    1145                 1150                 


<210>  31
<211>  10156
<212>  DNA
<213>  Homo sapiens

<400>  31
ggagcccatg atttcctgga agagccctag agctttgctt tttctctcct gcagcactta       60

accgaaacca gttttgcaat caattcctgt tcaaaggcca ccctactctt cctatccgtc      120

tttctccagc ccagacactc acagccccct gccagaccag gggacctcgg agaggcaagg      180

acagaggttc aggatcttcc tctccctcgg gacccaaggc cacaaaggag agctccgtgg      240

agagaagaaa atcatttgac tcctggggac acagatttgc tgccacagag gctgatggac      300

aaccaggcgg agagagaaag tgaggctggt gttggtttgc aaagggatga ggatgacgct      360

cctctgtgtg aagacgtgga gctacaagac ggagatctgt cccccgaaga aaaaatattt      420

ttgagagaat ttcccagatt gaaagaagat ctgaaaggga acattgacaa gctccgtgcc      480

ctcgcagacg atattgacaa aacccacaag aaattcacca aggctaacat ggtggccacc      540

tctactgctg tcatctctgg agtgatgagc ctcctgggtt tagcccttgc cccagcaaca      600

ggaggaggaa gcctgctgct ctccaccgct ggtcaaggtt tggcaacagc agctggggtc      660

accagcatcg tgagtggtac gttggaacgc tccaaaaata aagaagccca agcacgggcg      720

gaagacatac tgcccaccta cgaccaagag gacagggagg atgaggaaga gaaggcagac      780

tatgtcacag ctgctggaaa gattatctat aatcttagaa acaccttgaa gtatgccaag      840

aaaaacgtcc gtgcattttg gaaactcaga gccaacccac gcttggccaa tgctaccaag      900

cgtcttctga ccactggcca agtctcctcc cggagccgcg tgcaggtgca aaaggccttt      960

gcgggaacaa cactggcgat gaccaaaaat gctcgcgtgc tgggaggtgt gatgtccgcc     1020

ttctcccttg gctatgactt ggccactctc tcaaaggaat ggaagcacct gaaggaagga     1080

gcaaggacaa agtttgcgga agagttgaga gccaaggcct tggagctgga gaggaaactc     1140

acagaactca cccagctcta caagagcttg cagcagaaag tgaggtcaag ggccagaggg     1200

gtggggaagg atttaactgg gacctgcgaa accgaggctt actggaagga gttaagggag     1260

catgtgtgga tgtggctgtg gctgtgtgtg tgtctgtgtg tctgtgtgta tgtacagttt     1320

acatgaatgt tcctcaggac atggcataca atggccttgg aggtccaaat aatatcaagt     1380

acatcttgga gatgagggtg cctgtcctgg acagacctcg gcatgccttc tgtttctcct     1440

tcaatgctcc ttaaggccta tgtgctggga aaagggtctt ccctgtttgt ttgtttgttt     1500

gtttgtttgt ttgttttgag acagggtctc tgttgcccag gctggagtgc agtggcgtaa     1560

tctcggctca ctgcaacctc tgcctcctga gtgcaagcaa gtctcctgcc tcagcctccc     1620

aagtagctgg gattacaggc acgcaccacc acgcccagct aattttggta tttttttgta     1680

gagacagggt ttcaccattt tggccaggct ggtctcgaat tcctgacctc aagtgatcca     1740

cccaccttgg cctcccaaaa tgctgggatt acaagcgtga gctaccctgc ccagccgggt     1800

cttcccagtt ttaacaaaga ggtcacagag ccacaggcgg agttaggaac taaattgtct     1860

cctcctccca attcatatgt tgaagtccta aaccaaaatg tggctgtatt tagagatgga     1920

ccctttggga ggtaattagg gttgactgag gccatagggt gaggtcctaa cccgatggaa     1980

ttgacttctt tataagagga ggaggaaata caagagggcc tccccacccc tgctgcacac     2040

ctacactgaa ggaaggctat ttgcagatgc agcaagaagg cagccatctg caaggcagaa     2100

gaagagagcc ctcaccagga actgaataag tcagtcagtc tgggacttcc agcctctaga     2160

actgtgaaac aataaatttc tgtggtgtaa gcaactcaat ctatagtagt ttgttactat     2220

tttgttatag caaccaaaga tgactaagcc agacaggtta tgtcactcgc caagtgtctt     2280

agtctgtttg tgctgctata acaaaatacc ttagactggg taatttacaa acaacagaga     2340

tgtatccaga gatccacagt tctggaggct gagaagtcta aaatcaaggc accagcagat     2400

tccacatctc gtgaaggctc actctctgct tcacagatgg cactgtcttg ctgtgttctc     2460

acatggcaga aggggcaaac aagcccccct gggcctcttt tataaaggca ctaactctat     2520

gcctaaaggc agggccctca tgactctatc acctaccaaa aggctccact tctttatact     2580

attggagggg tagaaggaac ttcctttcta gaccttgaag gtttaagaat ttgaatctat     2640

aaaacaagct gacaatagac agattaacag gagaaaaagc atatacattt tttaatgtgg     2700

gccagatggc agaagcttaa ataacacccc aagctacagg aagtgaggcc tctgatgggg     2760

aggtagtgac acaggctgtg ggagggggta gggggaggaa gtctgtggtg agcaaagttt     2820

gccttattac actgataaag tgtaattaca ctaataaagc tggatcacct gaggttagga     2880

gtttgagaac agcctggcca acatggcaaa accctgtctc tactataaat acaaaaatta     2940

gccaggtgta gtggcagggc acttgtaatc ctatctactc gggaggctga ggcaggagaa     3000

tcgcttgaac ccaggctgta aaggttgcag tgagccaaga tcatgccact gcactccagt     3060

ctgggtgtca gaatgagacc ccatctcaaa aaaaaaaaaa aaaaaaaaaa agaagaagaa     3120

tacagtcatg tatctcttgg tgacagggac gcattctgat aaatgtgtca ttaggcaatt     3180

gcattgtagt gtgattatca cagattgtac ttatacaaaa cttagatggc atagcctact     3240

gcatacctag gctatatggg agagcctatt gctcccaggc tacgcacctg tacagcatgt     3300

gactactgaa tactataggc aattgcagca caatgggaaa tatttgtgta tctaaacata     3360

tgtaaacaga gaaaaaggaa agtaaaaata tggcataaaa gataagaatt ggctctcctg     3420

tacagggcac ttactacgaa tggagcttgc agggctgaga gttgctccag atgagtcagt     3480

gagtggtgaa tgaatgtgaa ggcctagggc attactgtat actactgtag gctttataaa     3540

cacagcacac ttagggtaca caaaatgcat attaaaacat tttcttcctt cagtatatta     3600

ggcaatagga atttttcaag tccactataa atcttatcaa accatggttg tatatgcagt     3660

tgaccgaaac attgttattg gacacataac tatagttgaa agaataagca aaaagtctat     3720

ctaggtgtgc tgtcttgagc aacttttaat tattctcctg tcctgcaata tgagttaatc     3780

ttctctgatc gatgtagatt ccaggaaggg gtgtccagga caattacctt ccttctggag     3840

aaacttccct taatcaaata agagaacttc aaagaaaatc cctccctgtg ctttggaagg     3900

gaagggaggt gggcagcagt gggtcagaga tagacctttg ttctcttatt tctgaggccc     3960

ttcagtctcc tttattcaaa gcactcagca tgccaaagca ccctatttta gggtatcttt     4020

ttctgagccc taaacactgt gttggggatg tcaactgtga caggaaaata tcttggggcc     4080

ccagaatcac taaggaaaac tcaagcttag ggaaacttct tagggcaaac ccacctccca     4140

ctctattcaa agttatctct ctgctcactg agatagatac atatctgatt gcctcctttg     4200

gaaaggctaa tcagaaactc aaaagaatgc aactgtttgt gtctcaccta tctgtgacct     4260

ggaagctccc tccccactga accaatgttc ttcttacata tattgattaa tgtcttatgt     4320

ctccctaaaa tgtataaaac caaggtatgc cccaaccatc ttggccacat gtcatcagga     4380

cttcctgagt ctgtgtcaca gtgtgtcctc aaccttggca aaataaactt tctaaattaa     4440

ctgagacctg tctcggattt tctgggttca cattttggaa accatgaatg gattctgggt     4500

ggagatgccc ctgacccttg acaaatctat cggtgcttgg taccagcatg agctaacttt     4560

atggctcaaa ccaataggac aatttgctga ggtctgagag gactccctcc agaaaatccc     4620

tgatctctta aaatttggta gagatcggaa gtttattttg ctgtacaaca cctctttttt     4680

tggagtttta cttgctccca acaaggaagg caagttttcc tgctttcatg atgatggaag     4740

gcaggtgatg tttttatgga gtttcagctt tcttccaatg cacttagagc actcagaaat     4800

tgtataattt gtgtgaccat tgttagtttt gcttaactgt tttgttgttt gtttctgtct     4860

tagtcaaatc tgaaggggaa ccctaaatta cggggtcaag gactctgaag tggtaggaaa     4920

acagccagct taaaaaactt tttttaaatt ttaattacta taggggcttt atttacataa     4980

cacagccagc tttttgctag ccagaccaaa ctcaaagagc aatggctgta cttctgaaat     5040

agcaacactt tgtcctagct gagatttggt aataagattt tttttttaag tttttaaaga     5100

agctcagtgg ttgaaagtct gcttaactga aacagtaaca tccatgatgt gtgttttgtg     5160

catgtttgta tttgaaaggc cttcatgttt ttgtttcttg tttgtttttc tctcctaaga     5220

ccttgtcttt tttttgtagc aaaagttttt tttttttttt tccttttact tctcagttga     5280

ctgaattctg ttttcaccgg attttttgac taaaatagct attgcaacag aggctactct     5340

tgggttaagg aagaatgtag tttcgtttta tgtttaatat cgctcaaaga aaaataaaag     5400

catctccctc taacaccacc agacttttcc tctctgtacc ttatcatgta aattttgcta     5460

tttgattttc acctgggttg tttcctttaa tgtgcaaaaa tttaaggcta tttagctgac     5520

aactgcctag ggttgtaaaa caggttatca agaatctgaa agtctaagat aggaaaaaaa     5580

agtggggggg cattataaat ctataaaatg tacttctatt ggcatgccta atacgtcttt     5640

atatgtatgt atgtgttgtg tacacgatgt tttagtgcta aaaatatgta aaagagctct     5700

acttggctta aagaaaaata aaagtgctta aatcagatac taaaaaagaa aaggctagtc     5760

aaatgctttt tcaaatttat gtaacttaag taaaatcttt aataaataaa gtagctttaa     5820

aattattggt aaagtagtat tagaaatgtc ttaagaattg ccagcataca tttttgtttg     5880

cattatatta atcaaacagt tttatactta tccctgccaa ataccagaag gtgtcaaaat     5940

ttggcatagg ggttataaaa ctataaaccc agcccaaaac agaatgatct ttgcttgtgt     6000

aatttttaat aaataagaca ttgatatggg tttaatgaaa acagctgcat cttgaattta     6060

gtaagattac cataacttct aatcctgtgg ctttaggcag tttagtccac agacaataag     6120

gaggtttgtt ttgggaaagg actgttattg tcattgtttc gaagctgaac ttaaactagg     6180

ttcctcccaa agttcattcg gcctatgccc aggaatgaac aaggacagct tggaagttaa     6240

gagcaaggtg gagtcagtta ggtcaaatcg tttttcactg tctcagttgt aattttgcaa     6300

tggaagtttc ataactttaa atcatgacta tcacagtttt tataaataat ctaggtaaac     6360

aattaataaa ataactaggt aaatgtaatg ggataaatac ttatagacca actggacata     6420

atttagaata taaagtcata ttaaattaaa taatagataa tttattattt gggtattttc     6480

caataaatat atcttgtagg aaaacattgt tgcttaaaaa aaagtgtgtc cttttttaaa     6540

aaaatggtga acaagttttg tctaattcaa agcttattaa aaggttatat ataaaacaag     6600

gtaaaaggaa ccagaaaaga aaaaaaatgt aaataaagtt ataaaaataa agaatttttt     6660

caaggttaaa aagctgaaaa agaaataatt ttatataaga aagaatttta tatggtaaat     6720

ttagtcctaa aataaaataa ctggttgttt aacaaggagg gatgttcagg acaaaccaga     6780

aagtccaagc atgtcatgaa cattggtgta agtcatgata agattttata tatatatata     6840

cacacacaca cacacacccc aaaagctttt atataatcaa gttgtcatat tattattaag     6900

ttttggtttg cttagggaag aaagagctaa tttttaaaaa atcaaggtta ttacatccat     6960

gtatcttcct gtgtatgctt ttaaagtcct tgtaacattg agttacaggg ctttaactcc     7020

tgtgtctgaa aaatcacaaa cactgatgac aatcaaagcc tcatcttaag gccccgtaga     7080

agatgccaat caaaataaac tgcattcctg aggcactagg caagaaatta aagctattca     7140

actcctcaag gcccagggac tattgcggaa gaggtgggcg cgtaagattg taagggccga     7200

ttttgaaaga tccagtaagt tcagtttctc tatgaactaa tcattcaagt caaaggcaca     7260

ctgatgcaaa atcagtatat ggacccctgt gtctgattag caaggttttc ttgaagcatt     7320

aaccaactcc ttcataaagg ttataaaagg cttatggaag ttatatttta taatcaagat     7380

taaatcttat agtttgttta caaaattttg aaaatcaaat gtgattggct tcaggctgtt     7440

tttattaggg cttcttgttt agaaagttaa gtcacctctc tcaaagaatg aaggtttttg     7500

ctttttttga aatccttgaa ttatcacttg gattaaataa atgactttac gatgacctgt     7560

aattttattt tgtaatgtca agtgttttaa accttttgta tttgacaagc tttccaaaat     7620

caaattataa attatgtatt tttctaacct aattaatcct ttaagatctt agtttcccta     7680

aagtcctaaa atgacataat ttggcttatt tggtataaaa attatatagg aagcattgtc     7740

aaatgtgaaa tggtgtttgg ttttctttgg gctgtatttg tataaatatg ttattggtgt     7800

atgttccaaa attatgtgaa actcctataa ttctaatata acttagtgta cattatcagt     7860

aataatcata attgttatat taaaattatt gtgtgccaca gaggtaaaaa atttccttgt     7920

cagttttgtc ttttgactat ggctgcctta aaactttttt cttccatgca caattgttgt     7980

tttggtcctc ttttttaaat atatttttat tattattttt gagatgggga ctcactctgt     8040

tgcccaggct ggagtgcagc ggcacgatct tggctcactg caactgccac ctcccaggtt     8100

caagcggttc tcctgcctca gcctcccgag tagctgggat tacaggcata caccaccatg     8160

cccagctaat ttttttgtat tttcagtaga gatggggttt caccatgttg gccaggctgg     8220

tcttgaactc ctgacctcag gtgatcagcc caccttggcc tctcaaagtg ctgaaattac     8280

agatgtgagc cacacacctg gcctattttg gtcctcttta gaaggtggtt ttataatcag     8340

ctgtaaaact ccaacaggtg ctcttacatg caggtttctg ataactttgg agattgtgac     8400

atcagaatag agggaaaagt ttcaggactc atggagagct aaaatgttca tgagtatcaa     8460

gcagaacagg aattaactgc atagactgaa ccaatctttt tgactttttg cttaaaatgt     8520

ttgctgatcc tttgttttgt gtttcagtct taaaactttt cttttgagct attgacagct     8580

tttaacaatt tagtatactc ctatgacaaa atttggagca tatttgtttc tctctacctg     8640

atttctccag aattcagaaa ctatttgtaa gtattcttaa cttatggtga tacagttatt     8700

tgcataagtg caataagaat ctgttctaat ttgtaacagg acacgattgg agaaattggt     8760

tgttttacta agactttgac tggaatggtg tgcttttctt taaggaatca aacttgactt     8820

atggaaccaa taaagtcctt ggaaaaactg gccccatatt ttgtgtacac agtctccgta     8880

caagatttct gacctgtagt aagtaaagaa tgtcactttc tgacaggcac ataagcccca     8940

ggtttacctc agaacctcaa gaggagagga aattcaccca atttataagt atttgatggc     9000

acaaatccat ggctgggcat ggctttaaga aagtcttatc tgagattcct cctgtggaac     9060

aaagttaatt ggttccagag attcaaagcc agagttgctg tcagttcatt ggtagagatg     9120

ccatcactgg gcaagtgttc tgaaaacatc ttatctgaat aacagcagtc ctggagaaca     9180

tctagggatc tagcaaagcg agagatacat gaaggacata aaaacgtttt tagaaagtcc     9240

ttggaaacag ttctcatttc agacatgtaa gcatgagcta ggatgaaaag tgatttcatc     9300

ctggtatctg caattttcac attcattagg tttcaacata taaactttca ggggacacag     9360

acattcagac tatagcacca agctgtagaa gctacatagt tgtagaccag ggtcagcaac     9420

ccaagaagcc tgacttccaa gctgtgcttt taacttcccc accatgttgc acctaaagct     9480

ttggagtttt cctgtgatta gtgtttttgg tgttgtttta ttttttttct tacaggaact     9540

cttgcaagaa gaaaggacta tgagttcaac tttagaggga gccatgggga ctaaacaaaa     9600

ttctgaggcc ccctcaacca tctaaatgga cttccttctg ggccaggaca ctcgaaaatt     9660

aaacctgaaa gactggttca ggccatgatg ggaagtggga gtcgaacatg cctcatcata     9720

ccctccagca ttaacatcaa cacagacctt aaggctgata agaagcattt acaatctatt     9780

ctctctgaag tcttctacct ggaggcttca tctgcatgat aaaactttgg tctccacaac     9840

ctcttacaac ccaggcattc ctttctatcg ataattactc tttcaaccaa ttgccaatca     9900

gaaaattgtt atatctacct ataatctaga agcccccaca tcaagttgtt ttgcctttct     9960

ggacaggacc aatgtatatc ttaaatgtat ttgattgatc tctcatgtct ccctaaaatg    10020

tataaaacca cgctgttccc cgaccacctg gagcacatgt tctcagggtc tcctgagggc    10080

tgtgtcacag gccatgttca cttacatttg gctcagaata aatctcttca aatattttaa    10140

aaaaaaaaaa aaaaaa                                                    10156


<210>  32
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Asp Asn Gln Ala Glu Arg Glu Ser Glu Ala Gly Val Gly Leu Gln 
1               5                   10                  15      


Arg Asp Glu Asp Asp Ala Pro Leu Cys Glu Asp Val Glu Leu Gln Asp 
            20                  25                  30          


Gly Asp Leu Ser Pro Glu Glu Lys Ile Phe Leu Arg Glu Phe Pro Arg 
        35                  40                  45              


Leu Lys Glu Asp Leu Lys Gly Asn Ile Asp Lys Leu Arg Ala Leu Ala 
    50                  55                  60                  


Asp Asp Ile Asp Lys Thr His Lys Lys Phe Thr Lys Ala Asn Met Val 
65                  70                  75                  80  


Ala Thr Ser Thr Ala Val Ile Ser Gly Val Met Ser Leu Leu Gly Leu 
                85                  90                  95      


Ala Leu Ala Pro Ala Thr Gly Gly Gly Ser Leu Leu Leu Ser Thr Ala 
            100                 105                 110         


Gly Gln Gly Leu Ala Thr Ala Ala Gly Val Thr Ser Ile Val Ser Gly 
        115                 120                 125             


Thr Leu Glu Arg Ser Lys Asn Lys Glu Ala Gln Ala Arg Ala Glu Asp 
    130                 135                 140                 


Ile Leu Pro Thr Tyr Asp Gln Glu Asp Arg Glu Asp Glu Glu Glu Lys 
145                 150                 155                 160 


Ala Asp Tyr Val Thr Ala Ala Gly Lys Ile Ile Tyr Asn Leu Arg Asn 
                165                 170                 175     


Thr Leu Lys Tyr Ala Lys Lys Asn Val Arg Ala Phe Trp Lys Leu Arg 
            180                 185                 190         


Ala Asn Pro Arg Leu Ala Asn Ala Thr Lys Arg Leu Leu Thr Thr Gly 
        195                 200                 205             


Gln Val Ser Ser Arg Ser Arg Val Gln Val Gln Lys Ala Phe Ala Gly 
    210                 215                 220                 


Thr Thr Leu Ala Met Thr Lys Asn Ala Arg Val Leu Gly Gly Val Met 
225                 230                 235                 240 


Ser Ala Phe Ser Leu Gly Tyr Asp Leu Ala Thr Leu Ser Lys Glu Trp 
                245                 250                 255     


Lys His Leu Lys Glu Gly Ala Arg Thr Lys Phe Ala Glu Glu Leu Arg 
            260                 265                 270         


Ala Lys Ala Leu Glu Leu Glu Arg Lys Leu Thr Glu Leu Thr Gln Leu 
        275                 280                 285             


Tyr Lys Ser Leu Gln Gln Lys Val Arg Ser Arg Ala Arg Gly Val Gly 
    290                 295                 300                 


Lys Asp Leu Thr Gly Thr Cys Glu Thr Glu Ala Tyr Trp Lys Glu Leu 
305                 310                 315                 320 


Arg Glu His Val Trp Met Trp Leu Trp Leu Cys Val Cys Leu Cys Val 
                325                 330                 335     


Cys Val Tyr Val Gln Phe Thr 
            340             


<210>  33
<211>  6330
<212>  DNA
<213>  Homo sapiens

<400>  33
tgacgccccc gaacccagct gcagaagctg ccgccacctc caatgcacaa ggtgtctcat       60

ctgaaaagaa acctgagccc cagggaggcg gcgcggagcg accctggcag agctggcgca      120

aacagggcga gaggtcgctg ggcagcgttc gaggaccaga gggagctcgg ccacagaaga      180

ccccagtgat ctgatcccgg gatcccggct ccaagctctc ctcgcatttt acagatttca      240

cccccgcgac tatctcccca aaacggagcc tttatatcaa gagaaggtgc gggagctggg      300

gcaaccagga ctttctcggg cacccaagat gcgctccatt aggaagaggt ggacgatctg      360

cacaataagt ctgctcctga tcttttataa gacaaaagaa atagcaagaa ctgaggagca      420

ccaggagacg caactcatcg gagatggtga attgtctttg agtcggtcac ttgtcaatag      480

ctctgataaa atcattcgaa aggctggctc ttcaatcttc cagcacaatg tagaaggttg      540

gaaaatcaat tcctctttgg tcctagagat aaggaagaac atacttcgtt tcttagatgc      600

agaacgagat gtgtcagtgg tcaagagcag ttttaagcct ggtgatgtca tacactatgt      660

gcttgacagg cgccggacac taaacatttc tcatgatcta catagcctcc tacctgaagt      720

ttcaccaatg aagaatcgca ggtttaagac ctgtgcagtt gttggaaatt ctggcattct      780

gttagacagt gaatgtggaa aggagattga cagtcacaat tttgtaataa ggtgtaatct      840

agctcctgtg gtggagtttg ctgcagatgt gggaactaaa tcagatttta ttaccatgaa      900

tccatcagtt gtacaaagag catttggagg ctttcgaaat gagagtgaca gagaaaaatt      960

tgtgcataga ctttccatgc tgaatgacag tgtcctttgg attcctgctt tcatggtcaa     1020

aggaggagag aagcacgtgg agtgggttaa tgcattaatc cttaagaata aactgaaagt     1080

gcgaactgcc tatccgtcat tgagacttat tcatgctgtc agaggttact ggctgaccaa     1140

caaagttcct atcaaaagac ccagcacagg tcttctcatg tatacacttg ccacaagatt     1200

ctgtgatgaa attcacctgt atggattctg gcccttccct aaggatttaa atggaaaagc     1260

ggtcaaatat cattattatg atgacttaaa atataggtac ttttccaatg caagccctca     1320

cagaatgcca ttagaattca aaacattaaa tgtgctacat aatagaggag ctctaaaact     1380

gacaacagga aagtgtgtaa agcaataaag cacattttga aacaaacaat atgcacttct     1440

tttctgaaga tgcttccgaa gatttgaaaa taggatccaa aacacggctg ggtttcagca     1500

tccaccaatg aactgaaagg tgaataaagg acgttcatga gaaatcgact accagctgat     1560

gaaatacctg caaagtgctc taaaaattaa atattttgac tttaagggtc ctagtaagtg     1620

ccacttccac taagaataca gtttgaatgt ataatcagta gtgtttacaa gatccaacag     1680

tgcactcatc attagttaac aaagcaaata tgttcatcac tgtcaggctg cccacagcaa     1740

caccaagcat attagaagag gaaccccagg aacgcaactc agaccttggg aaattaaacc     1800

atccttgtca gcagaagcca agatggaagc agtttgagca atgaaatccg taagattaaa     1860

caactcaagt aaatgcttca gtcaggactc tgagtctgat catgaatttt atgttttaat     1920

ttatgttttt tttttgtctt ctggaatctc ttttggtttg gatattggga tgcttagaaa     1980

tcctttctga gatgcatatg agtgaggaaa taaactttaa gtaattattt ttaaagttct     2040

tatacttttt aaaagctatc acacaaagac tttttttttt ttttttgtct cgctctgttg     2100

cccaggctgg agtacagtgg cgcgatctca gctcactgca agctccgcct cccaagttca     2160

ctccattctc ctgcctcagc ctccggagta gctgggactg caggcgcctg ccaccacgcc     2220

tggctaattt tttgtatttt tagtggagac ggattttcac cgtgttagcc aggatggtct     2280

caatctcctg acctcgtgat ccacccgcct tggcctccca aagtgctggg attacaggcg     2340

tgagccaccg tgcctggccg acatttttaa aaaagtttta ttttgcacgg ctctaaacct     2400

ccatgttatt ttccagtggt gtagaaggta ccagctaaag tgaaccacta tgtaatatta     2460

ggccattcta aaggaaagat gttccatgtc atcagagatg gtaaaatagg ccgggaaaaa     2520

aaaatctttg gtaccaaaga ttacacttgt gtttctacac agcaaaccat ttttctttca     2580

tgaaaataat atattattaa catgaatata ttattttgct attaatgtga aagttgtctc     2640

taaatatttt ttaattttca aactcatact ttattttcat ttgaaatgtt tttcacacct     2700

tttgcattac ataataattt tgtggaagca ttttgccctt tagaataaat attagattga     2760

tatagctgaa atgtgacttc cagttctttg atattcccct tgttattcaa atagaaatat     2820

ggaaatgctt tatatattac tgttaaattt cttagtgcag aaataacatt attaatagag     2880

tattgttttc aaaacagaga tgattaattt caagaggttt aacagtgaaa ttgtgtcaat     2940

attttgcatt taaaatgaat ttaattgacc gatattttct gtagttaaat ttagtcacaa     3000

tatcacatat gttcttcaag aaacacatga aattattaat aaagtaatta aaaaattttt     3060

aatgtataac agaattgacc aataggccag ttttctggta acttatgata gtagattgtt     3120

tctttagaaa ctgggcagaa gctctgcatt ctcacttgta ctttgatttc ttatttcttg     3180

ggcaggcaat ttgaggaaag aagaaatggc atggggaata tatatgtttt gtttcttagg     3240

gaaaacagtc tgagaaatga ataaaaagca tgaagtacgt gtgtgtgtgt gtgtgttacc     3300

atggaaaagg atattcacag tagtacagtt ctcaatattt ttaattagat gtcatatttt     3360

tttaatatag taaaaccttg ggatatagaa tattacatct tttgagaatg tatgtgtctc     3420

taagtaagta aaatctaatg cgtataggag actgatagct aaaaatgaat ggaacattaa     3480

tgtactttta taattaaacc tcttatctat cagaaattgt aagagaatag atacatgttt     3540

tgaatgtaaa gttgaaaagt ctggtttact taataaattg aaagtgattt ataaaatcta     3600

aatttggact acttgcaaat gataagctat tctagtagcc tttagtttaa atccaacaga     3660

aatctagaag tcacaagcaa atatcttaaa ggtaaaatcc atctgggcac tcatttaaag     3720

tatatcttaa aaaagcagca gcaaggtacc ttgccatttt tagcatattt tcttcctttt     3780

tcttttttct tttttttttt tttttgagat ggagtctcac tctgtcacac aggctggaat     3840

gcagtgatgc catctcagct cactgcaacc tccacctcct gggttcaagt gattctcgtg     3900

cctcagcctc ccaagtagct ggggttacag gcgcccacca ccacactcgg ctaattttgt     3960

gtttttagta gagacaaagt ttcaccatgt tggccaggct ggtcttgaac ttcctgacct     4020

caggttatcc acccacctca gcctcccaaa gtgctgggat tacaggtgtg agccaccgca     4080

gccggaccat ttttagtata ttttcagtaa atacatttaa acaatgttaa ggccacagca     4140

cacatatctc agccattcat tgttctgtgc attgatgttt atctcataga tgcattgagt     4200

agtgcctttt tagctttttc acattacttt gtcaccatat cctttgtgtt ctctaaatac     4260

attgcccact tccaaaaatg ttcagcatga aaaaaagggc ttcagtgtcg attgagattg     4320

cttttgttca tctcagggat ttcaatagtc aagaatgaat tcagttaaag gtatttaggg     4380

ttcaaagaag acaaactgta caagcccatt tcattccttg ttgtatacct ttccatctgc     4440

cctcccattt taactatcta ctgtggcctt tttatggaaa cagagcaaga tcaatgaagg     4500

ctaatggcaa gaataagaaa aagagttgag atttaaccaa tagcggagca taaaggatca     4560

tgacaaaatc aaattataaa agcatacttg aaataggtgg agctttttct tttgaaaata     4620

tatattcaca attttaatat tttaatttat tttttactat ttaaccctgt acttggcaat     4680

gctcaggcag ctgattgtga aatattcttg tcctttacag aacatggttg ttattgtgct     4740

gttgacatga atagaccatg gaaacatttt catcattatt attcagcctg tgctgtagtt     4800

aatgttaagt tgctgaaata aaaagtgagc aagtaataga ttttcttggc aaatctaatg     4860

attcagccca caggactgtt gaaactactg cggaagtttt tctatctgaa agaaggtgct     4920

gggcattcaa atgtgttcat gtattgtata tcatatgaat tgtatatcaa ttactaatgg     4980

gaatttctac atatatgctt acaaaagcaa tttatttaag taatgctagg ggtagtgtac     5040

ataccaatta gttattcagc tactatacag aaaaaggatg aacaaattaa tttatttcta     5100

attgagccag ttagacataa tgcatataac gtgatatttg gttcatgaaa gagttgtttt     5160

catgtggtta ttgtagggag tatatataat tgtggaaggg gtatgggaag agttgtgtat     5220

agttagttgt tatctctaca agtttgaaag ttttcccatc aaacattatc aatataccaa     5280

tgttttaaaa attgagtgag ggttattatt tgtatttgat gaaagaaaat ccaaataaag     5340

cccacctaga aatagatatt ttattatata tgtgctatag atatacctat atagtacaaa     5400

tagacatgtg tgatgcatat atacaatgtt atatatgtgt atatgtctgt atacacactg     5460

agtctgtaat atgtatacac taaatttgtg ttatgctaac atcttcaggg tctgcactgt     5520

gaactcccct ggagataagt aagtccactt tagaataaag aagttctttt gagacttcag     5580

ttactaacgt gctttaagag gtatctactt tataactgaa ttctatgtcg ttcatacgta     5640

gagttacagt aagggtctag tatgtccaaa tcttaataat aaagaagaaa agtaaaggct     5700

tcaagctagc aatgtattcg aattacagtt ttcagattgt ggctccaggc cttgtgtttc     5760

tcatttaagt agcacctttt aataaaaacc gtttctttgt gtaggcaaaa gcacaagtgt     5820

ttcaaatgta aatagcagga aaaaaaaaga gtttacagag atagcattgc tgcacagaat     5880

aattgctact gagtatttct tatagaattt gtggaactga aagatgaggt ttattctgtc     5940

aagttcaagt tcattctgtt caacactgtt ttcttattgt ttgtgtatag caaccgggta     6000

ttattgtttt atcatttgta aaattgtaaa ataaattaat cccttttttt cactgtttct     6060

cttatctcat atatccaagc ccttggttat actttgtatg tcaatgttag gtgatcattt     6120

ttaacaagct ttggcttgtg ctttgctttt ccactcccct tagccctagt ggttggcaat     6180

taggcaaacc atttattttt aagtgtatac atgggaatat gaacaatgtc aaaaacccca     6240

tgaatattag gaaatcctta acgatatttt gtgtagcaca ttctgtttgc ggttgaggga     6300

ataaagtatt tcacaagtga aaaaaaaaaa                                      6330


<210>  34
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Arg Ser Ile Arg Lys Arg Trp Thr Ile Cys Thr Ile Ser Leu Leu 
1               5                   10                  15      


Leu Ile Phe Tyr Lys Thr Lys Glu Ile Ala Arg Thr Glu Glu His Gln 
            20                  25                  30          


Glu Thr Gln Leu Ile Gly Asp Gly Glu Leu Ser Leu Ser Arg Ser Leu 
        35                  40                  45              


Val Asn Ser Ser Asp Lys Ile Ile Arg Lys Ala Gly Ser Ser Ile Phe 
    50                  55                  60                  


Gln His Asn Val Glu Gly Trp Lys Ile Asn Ser Ser Leu Val Leu Glu 
65                  70                  75                  80  


Ile Arg Lys Asn Ile Leu Arg Phe Leu Asp Ala Glu Arg Asp Val Ser 
                85                  90                  95      


Val Val Lys Ser Ser Phe Lys Pro Gly Asp Val Ile His Tyr Val Leu 
            100                 105                 110         


Asp Arg Arg Arg Thr Leu Asn Ile Ser His Asp Leu His Ser Leu Leu 
        115                 120                 125             


Pro Glu Val Ser Pro Met Lys Asn Arg Arg Phe Lys Thr Cys Ala Val 
    130                 135                 140                 


Val Gly Asn Ser Gly Ile Leu Leu Asp Ser Glu Cys Gly Lys Glu Ile 
145                 150                 155                 160 


Asp Ser His Asn Phe Val Ile Arg Cys Asn Leu Ala Pro Val Val Glu 
                165                 170                 175     


Phe Ala Ala Asp Val Gly Thr Lys Ser Asp Phe Ile Thr Met Asn Pro 
            180                 185                 190         


Ser Val Val Gln Arg Ala Phe Gly Gly Phe Arg Asn Glu Ser Asp Arg 
        195                 200                 205             


Glu Lys Phe Val His Arg Leu Ser Met Leu Asn Asp Ser Val Leu Trp 
    210                 215                 220                 


Ile Pro Ala Phe Met Val Lys Gly Gly Glu Lys His Val Glu Trp Val 
225                 230                 235                 240 


Asn Ala Leu Ile Leu Lys Asn Lys Leu Lys Val Arg Thr Ala Tyr Pro 
                245                 250                 255     


Ser Leu Arg Leu Ile His Ala Val Arg Gly Tyr Trp Leu Thr Asn Lys 
            260                 265                 270         


Val Pro Ile Lys Arg Pro Ser Thr Gly Leu Leu Met Tyr Thr Leu Ala 
        275                 280                 285             


Thr Arg Phe Cys Asp Glu Ile His Leu Tyr Gly Phe Trp Pro Phe Pro 
    290                 295                 300                 


Lys Asp Leu Asn Gly Lys Ala Val Lys Tyr His Tyr Tyr Asp Asp Leu 
305                 310                 315                 320 


Lys Tyr Arg Tyr Phe Ser Asn Ala Ser Pro His Arg Met Pro Leu Glu 
                325                 330                 335     


Phe Lys Thr Leu Asn Val Leu His Asn Arg Gly Ala Leu Lys Leu Thr 
            340                 345                 350         


Thr Gly Lys Cys Val Lys Gln 
        355                 


<210>  35
<211>  1448
<212>  DNA
<213>  Homo sapiens

<400>  35
agtgagaggc cgggggtgtg gtagagagaa ggagccggcc gggtacttag gaccgcgcca       60

gcctctgagc ccggcctcct tcgcactttc gagtgcgcgt ttgctgcccg ccgcagcccg      120

ggcgttgaag gtagtaaagc ggccacccgg ccgcatcatg gtgaccccct gtcccaccag      180

cccctcgagc cccgccgccc gagcggggag gcgggacaac gaccagaacc ttcgcgcccc      240

ggtgaagaag agcaggcgtc cgcgcctccg gaggaagcag ccgctgcatc ccctgaaccc      300

gtgcccgctc ccgggagact ccggcatttg cgacctgttc gagtccccca gctccggctc      360

agacggcgca gagagcccct ctgcggcgcg gggtggtagc cccctgcccg gcccggccca      420

gcccgtggcg cagctagatc tacagacctt ccgcgactac ggccagagct gctacgcctt      480

ccgcaaggcg caggagagcc acttccaccc gcgggaggcg ctggcacggc agccacaagt      540

gacggcggaa tcccgctgta agctgctcag ctggctgatc ccggtgcacc gccaattcgg      600

cctctccttc gagtcgctgt gcctgacggt gaacactctg gaccgcttcc tcaccaccac      660

gccggtggct gcagactgct tccagctgct tggggtcacc tccttgctca tcgcttgcaa      720

acaggtggag gtgcacccgc cgcgcgtgaa gcagcttctg gccctctgct gcggcgcctt      780

ctcccggcag cagctctgca acctcgagtg catcgtgctg cacaagctgc acttcaccct      840

gggtgcgccc accattagct tcttcctgga gcatttcacg cacgctcgcg tggaggcggg      900

gcaggctgag gcctccgaag ctctggaagc gcaagccctg gcgcgggggg tggcagagct      960

gagtctggcc gactatgcct tcaccagcta ctccccttcc ctcctggcga tctgctgcct     1020

ggcgctggcg gaccgcatgc tgcgggtctc gcggcccgtg gacttgcgac tgggagacca     1080

cccggaggcg gcgctggagg actgtatggg caagttgcag ctgctggtgg ccataaacag     1140

tacttccttg actcacatgc tgcccgttca gatctgcgag aagtgcagcc tgcccccgag     1200

ctcgaaataa aacagatcct tcgtttcctt ttagtccctg gcccggctgc tggacctctc     1260

ccgtagcctc agaagagtgc agtactggtc cacagagaag gcttcaggac ctgcttggtc     1320

agctgcaggt tgtaaatagt gtacgatact agcatctggt attttattta ttttgcagcg     1380

agcacatgag gaagctgagt ctttcaccaa taaacagttg tggtttgtct aaaaaaaaaa     1440

aaaaaaaa                                                              1448


<210>  36
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Val Thr Pro Cys Pro Thr Ser Pro Ser Ser Pro Ala Ala Arg Ala 
1               5                   10                  15      


Gly Arg Arg Asp Asn Asp Gln Asn Leu Arg Ala Pro Val Lys Lys Ser 
            20                  25                  30          


Arg Arg Pro Arg Leu Arg Arg Lys Gln Pro Leu His Pro Leu Asn Pro 
        35                  40                  45              


Cys Pro Leu Pro Gly Asp Ser Gly Ile Cys Asp Leu Phe Glu Ser Pro 
    50                  55                  60                  


Ser Ser Gly Ser Asp Gly Ala Glu Ser Pro Ser Ala Ala Arg Gly Gly 
65                  70                  75                  80  


Ser Pro Leu Pro Gly Pro Ala Gln Pro Val Ala Gln Leu Asp Leu Gln 
                85                  90                  95      


Thr Phe Arg Asp Tyr Gly Gln Ser Cys Tyr Ala Phe Arg Lys Ala Gln 
            100                 105                 110         


Glu Ser His Phe His Pro Arg Glu Ala Leu Ala Arg Gln Pro Gln Val 
        115                 120                 125             


Thr Ala Glu Ser Arg Cys Lys Leu Leu Ser Trp Leu Ile Pro Val His 
    130                 135                 140                 


Arg Gln Phe Gly Leu Ser Phe Glu Ser Leu Cys Leu Thr Val Asn Thr 
145                 150                 155                 160 


Leu Asp Arg Phe Leu Thr Thr Thr Pro Val Ala Ala Asp Cys Phe Gln 
                165                 170                 175     


Leu Leu Gly Val Thr Ser Leu Leu Ile Ala Cys Lys Gln Val Glu Val 
            180                 185                 190         


His Pro Pro Arg Val Lys Gln Leu Leu Ala Leu Cys Cys Gly Ala Phe 
        195                 200                 205             


Ser Arg Gln Gln Leu Cys Asn Leu Glu Cys Ile Val Leu His Lys Leu 
    210                 215                 220                 


His Phe Thr Leu Gly Ala Pro Thr Ile Ser Phe Phe Leu Glu His Phe 
225                 230                 235                 240 


Thr His Ala Arg Val Glu Ala Gly Gln Ala Glu Ala Ser Glu Ala Leu 
                245                 250                 255     


Glu Ala Gln Ala Leu Ala Arg Gly Val Ala Glu Leu Ser Leu Ala Asp 
            260                 265                 270         


Tyr Ala Phe Thr Ser Tyr Ser Pro Ser Leu Leu Ala Ile Cys Cys Leu 
        275                 280                 285             


Ala Leu Ala Asp Arg Met Leu Arg Val Ser Arg Pro Val Asp Leu Arg 
    290                 295                 300                 


Leu Gly Asp His Pro Glu Ala Ala Leu Glu Asp Cys Met Gly Lys Leu 
305                 310                 315                 320 


Gln Leu Leu Val Ala Ile Asn Ser Thr Ser Leu Thr His Met Leu Pro 
                325                 330                 335     


Val Gln Ile Cys Glu Lys Cys Ser Leu Pro Pro Ser Ser Lys 
            340                 345                 350 


<210>  37
<211>  2793
<212>  DNA
<213>  Homo sapiens

<400>  37
atggagatca gaggggcact cgatctgcga aaaaggcaag ttctaatatt ccttgttttg       60

ctgggattgt ctcgggcagg tactgaatct gcacactatt ctgtggcaga ggaaacagaa      120

attggctctt ttgtggctaa tctagcgagg gacctagggc tgggggtgga ggagctgtct      180

tcacgtgaag cccgggtagt gtctgatgat aataaaaagt atttgcacct tgatttgctg      240

actgggaatt tgctcctaaa tgagaaacta gaccgagacg agctgtgtgg ctccaccgag      300

ccctgtgtgc tgcattttca ggtggttttg gaaaaccctt tacagttttt tcggtttgag      360

ctgtgtgtca aagacataaa tgatcactcc cctacatttc tagacaagga aatacttatt      420

aaaatatcag aaggtaccac tgttggagct acctttctaa tggagagtgc tcaagatttg      480

gatgtcggaa gcaacagtct ccaaaactac acaattagcc ccaattctca cttctacatt      540

aaaattcccg acagtagtga cagaaagata tacccagagc tggtcctaga tagagcttta      600

gattatgaac aggaagctga actcagatta acactcacag cagtggatgg tggatccccg      660

cccaagtctg ggacaacttt ggttctcatc aaggtgttgg acatcaatga taatgcccct      720

gagtttcctc agagtctcta tgaggtgcaa gtccccgagg acagacccct tggctcctgg      780

attgccacca tctcagctaa ggatctggat gcaggaaact atggaaaaat atcttacaca      840

tttttccatg catcagaaga tattcgtaaa acatttgaaa ttaatccaat atctggggaa      900

gttaatttga gatcacccct ggattttgaa gtaatacagt cctacactat aaatattcag      960

gcaacagatg gtgggggtct ttcaggaaaa tgcacccttc tagttaaagt tatggatata     1020

aacgacaacc caccagaagt gaccatatcg tcgattacaa agagaattcc agagaatgcc     1080

tcagagaccc tagtagctct ttttagtatc ctagaccaag actctggaga caatgggagg     1140

atgatttgct ctattcaaga taacctccct tttttcctga aaccgacctt caagaacttt     1200

ttcactctag tttctgaaaa agcactggac agagagagcc aagccgagta caacatcacg     1260

atcaccgtca cagacttggg gacacccagg ctgaaaaccg agtacaacat aaccgtgctg     1320

ctctctgacg tcaatgacaa cgcccccacc ttcacccaaa cctcctacac cctgttcgtc     1380

cgcgagaaca acagccccgc cctgcacatc ggcagcgtca gcgccacaga cagagactca     1440

ggcaccaacg cccaggtcaa ctactcgctg ctgccgcccc aggaccggca cctgcccctc     1500

gcctccttgg tctccatcaa cgcggacaat ggccacctgt ttgccctcag gtcgctggac     1560

tacgaggccc tacaggagtt cgagtttcgc gtgggcgcca cagaccgcgg gtccccggcg     1620

ttgagcagcg aggcgctggt gcgcgtgctg gtgctggacg ccaacgacaa ctcgcccttc     1680

gtgctgtacc cgctgcagaa cggctccgcg ccctgcaccg agctggtgcc ccgggcggcc     1740

gagccgggct acctggtgac caaggtggtg gcggtggacg gcgactcggg ccagaacgcc     1800

tggctgtcgt accagctgct caaggccacg gagcccgggc tgttcggcgt gtgggcgcac     1860

aatggcgagg tgcgcaccgc caggctgctg agcgagcgcg acgcggccaa gcacaggctg     1920

gtggtgctgg tcaaggacaa tggcgagcct cctcgctcgg ccaccgccac gctgcacgtg     1980

ctcctggtgg acggcttctc ccagccctac ctgccgctcc ctgaggcggc cccggcccag     2040

gcccaggccg actccctcac cgtctacctg gtggtggcat tggcctcggt gtcgtcgctc     2100

ttcctcttct cggtgctcct gttcgtggcg gtgcggctgt gcaggaggag cagggcggcc     2160

tcggtgggtc gctgctcggt gcccgagggt ccctttccag ggcatctggt ggacgtgagc     2220

ggcaccggga ccctgtccca gagctaccaa tacgaggtgt gtctgacagg aggttccggg     2280

acaaatgagt tcaaatttct gaagccgatt atccccaatt ttcaagttca tgacactggt     2340

aggaatatgg gggaaatcga gaactttcga aatagctttg gacttaacat tcaataaaac     2400

aatttatttt aaatgtctaa tttttggtta ttcttggcaa gctgatggta ctttttgcat     2460

aatcttttgt ggattcttgg ttgtactgta gttgcatgca tgattatagc tcttgttttt     2520

ctcacagttt ctttaaaaat ctttattagt ggctataatg acgtggaaat gtaatctgtg     2580

ttttctggtt tttcatttat ttggccaaaa tgttatatta atggagttat tgctattttt     2640

gctgtgataa tggtattatg caagaccata ttctcaatta tttggatatg caaactaaag     2700

tattaagagc taatgtcatt atatatgtaa cttaaatcta gacaccatca aagcataaaa     2760

taaaaataaa aagcgttgct gaaaaaaaaa aaa                                  2793


<210>  38
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Glu Ile Arg Gly Ala Leu Asp Leu Arg Lys Arg Gln Val Leu Ile 
1               5                   10                  15      


Phe Leu Val Leu Leu Gly Leu Ser Arg Ala Gly Thr Glu Ser Ala His 
            20                  25                  30          


Tyr Ser Val Ala Glu Glu Thr Glu Ile Gly Ser Phe Val Ala Asn Leu 
        35                  40                  45              


Ala Arg Asp Leu Gly Leu Gly Val Glu Glu Leu Ser Ser Arg Glu Ala 
    50                  55                  60                  


Arg Val Val Ser Asp Asp Asn Lys Lys Tyr Leu His Leu Asp Leu Leu 
65                  70                  75                  80  


Thr Gly Asn Leu Leu Leu Asn Glu Lys Leu Asp Arg Asp Glu Leu Cys 
                85                  90                  95      


Gly Ser Thr Glu Pro Cys Val Leu His Phe Gln Val Val Leu Glu Asn 
            100                 105                 110         


Pro Leu Gln Phe Phe Arg Phe Glu Leu Cys Val Lys Asp Ile Asn Asp 
        115                 120                 125             


His Ser Pro Thr Phe Leu Asp Lys Glu Ile Leu Ile Lys Ile Ser Glu 
    130                 135                 140                 


Gly Thr Thr Val Gly Ala Thr Phe Leu Met Glu Ser Ala Gln Asp Leu 
145                 150                 155                 160 


Asp Val Gly Ser Asn Ser Leu Gln Asn Tyr Thr Ile Ser Pro Asn Ser 
                165                 170                 175     


His Phe Tyr Ile Lys Ile Pro Asp Ser Ser Asp Arg Lys Ile Tyr Pro 
            180                 185                 190         


Glu Leu Val Leu Asp Arg Ala Leu Asp Tyr Glu Gln Glu Ala Glu Leu 
        195                 200                 205             


Arg Leu Thr Leu Thr Ala Val Asp Gly Gly Ser Pro Pro Lys Ser Gly 
    210                 215                 220                 


Thr Thr Leu Val Leu Ile Lys Val Leu Asp Ile Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Glu Phe Pro Gln Ser Leu Tyr Glu Val Gln Val Pro Glu Asp Arg Pro 
                245                 250                 255     


Leu Gly Ser Trp Ile Ala Thr Ile Ser Ala Lys Asp Leu Asp Ala Gly 
            260                 265                 270         


Asn Tyr Gly Lys Ile Ser Tyr Thr Phe Phe His Ala Ser Glu Asp Ile 
        275                 280                 285             


Arg Lys Thr Phe Glu Ile Asn Pro Ile Ser Gly Glu Val Asn Leu Arg 
    290                 295                 300                 


Ser Pro Leu Asp Phe Glu Val Ile Gln Ser Tyr Thr Ile Asn Ile Gln 
305                 310                 315                 320 


Ala Thr Asp Gly Gly Gly Leu Ser Gly Lys Cys Thr Leu Leu Val Lys 
                325                 330                 335     


Val Met Asp Ile Asn Asp Asn Pro Pro Glu Val Thr Ile Ser Ser Ile 
            340                 345                 350         


Thr Lys Arg Ile Pro Glu Asn Ala Ser Glu Thr Leu Val Ala Leu Phe 
        355                 360                 365             


Ser Ile Leu Asp Gln Asp Ser Gly Asp Asn Gly Arg Met Ile Cys Ser 
    370                 375                 380                 


Ile Gln Asp Asn Leu Pro Phe Phe Leu Lys Pro Thr Phe Lys Asn Phe 
385                 390                 395                 400 


Phe Thr Leu Val Ser Glu Lys Ala Leu Asp Arg Glu Ser Gln Ala Glu 
                405                 410                 415     


Tyr Asn Ile Thr Ile Thr Val Thr Asp Leu Gly Thr Pro Arg Leu Lys 
            420                 425                 430         


Thr Glu Tyr Asn Ile Thr Val Leu Leu Ser Asp Val Asn Asp Asn Ala 
        435                 440                 445             


Pro Thr Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn 
    450                 455                 460                 


Ser Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser 
465                 470                 475                 480 


Gly Thr Asn Ala Gln Val Asn Tyr Ser Leu Leu Pro Pro Gln Asp Arg 
                485                 490                 495     


His Leu Pro Leu Ala Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His 
            500                 505                 510         


Leu Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Glu Phe Glu 
        515                 520                 525             


Phe Arg Val Gly Ala Thr Asp Arg Gly Ser Pro Ala Leu Ser Ser Glu 
    530                 535                 540                 


Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe 
545                 550                 555                 560 


Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val 
                565                 570                 575     


Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val 
            580                 585                 590         


Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys 
        595                 600                 605             


Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val 
    610                 615                 620                 


Arg Thr Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu 
625                 630                 635                 640 


Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala 
                645                 650                 655     


Thr Leu His Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro 
            660                 665                 670         


Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Ser Leu Thr Val 
        675                 680                 685             


Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser 
    690                 695                 700                 


Val Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala 
705                 710                 715                 720 


Ser Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly His Leu 
                725                 730                 735     


Val Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln Tyr Glu 
            740                 745                 750         


Val Cys Leu Thr Gly Gly Ser Gly Thr Asn Glu Phe Lys Phe Leu Lys 
        755                 760                 765             


Pro Ile Ile Pro Asn Phe Gln Val His Asp Thr Gly Arg Asn Met Gly 
    770                 775                 780                 


Glu Ile Glu Asn Phe Arg Asn Ser Phe Gly Leu Asn Ile Gln 
785                 790                 795             


<210>  39
<211>  6082
<212>  DNA
<213>  Homo sapiens

<400>  39
ataacgtctt tgtcactaaa atgttcccca ggggccttcg gcgagtcttt ttgtttggtt       60

ttttgttttt aatctgtggc tcttgataat ttatctagtg gttgcctaca cctgaaaaac      120

aagacacagt gtttaactat caacgaaaga actggacggc tccccgccgc agtcccactc      180

cccgagtttg tggctggcat ttgggccacg ccgggctggg cggtcacagc gaggggcgcg      240

cagtttgggg tcacacagct ccgcttctag gccccaacca ccgttaaaag gggaagcccg      300

tgccccatca ggtccgctct tgctgagccc agagccatcc cgcgctctgc gggctgggag      360

gcccgggcca ggacgcgagt cctgcgcagc cgaggttccc cagcgccccc tgcagccgcg      420

cgtaggcaga gacggagccc ggccctgcgc ctccgcacca cgcccgggac cccacccagc      480

ggcccgtacc cggagaagca gcgcgagcac ccgaagctcc cggctggcgg cagaaaccgg      540

gagtggggcc gggcgagtgc gcggcatccc aggccggccc gaacgctccg cccgcggtgg      600

gccgacttcc cctcctcttc cctctctcct tcctttagcc cgctggcgcc ggacacgctg      660

cgcctcatct cttggggcgt tcttccccgt tggccaaccg tcgcatcccg tgcaactttg      720

gggtagtggc cgtttagtgt tgaatgttcc ccaccgagag cgcatggctt gggaagcgag      780

gcgcgaaccc ggcccccgaa gggccgccgt ccgggagacg gtgatgctgt tgctgtgcct      840

gggggtcccg accggccgcc cctacaacgt ggacactgag agcgcgctgc tttaccaggg      900

cccccacaac acgctgttcg gctactcggt cgtgctgcac agccacgggg cgaaccgatg      960

gctcctagtg ggtgcgccca ctgccaactg gctcgccaac gcttcagtga tcaatcccgg     1020

ggcgatttac agatgcagga tcggaaagaa tcccggccag acgtgcgaac agctccagct     1080

gggtagccct aatggagaac cttgtggaaa gacttgtttg gaagagagag acaatcagtg     1140

gttgggggtc acactttcca gacagccagg agaaaatgga tccatcgtga cttgtgggca     1200

tagatggaaa aatatatttt acataaagaa tgaaaataag ctccccactg gtggttgcta     1260

tggagtgccc cctgatttac gaacagaact gagtaaaaga atagctccgt gttatcaaga     1320

ttatgtgaaa aaatttggag aaaattttgc atcatgtcaa gctggaatat ccagttttta     1380

cacaaaggat ttaattgtga tgggggcccc aggatcatct tactggactg gctctctttt     1440

tgtctacaat ataactacaa ataaatacaa ggctttttta gacaaacaaa atcaagtaaa     1500

atttggaagt tatttaggat attcagtcgg agctggtcat tttcggagcc agcatactac     1560

cgaagtagtc ggaggagctc ctcaacatga gcagattggt aaggcatata tattcagcat     1620

tgatgaaaaa gaactaaata tcttacatga aatgaaaggt aaaaagcttg gatcgtactt     1680

tggagcttct gtctgtgctg tggacctcaa tgcagatggc ttctcagatc tgctcgtggg     1740

agcacccatg cagagcacca tcagagagga aggaagagtg tttgtgtaca tcaactctgg     1800

ctcgggagca gtaatgaatg caatggaaac aaacctcgtt ggaagtgaca aatatgctgc     1860

aagatttggg gaatctatag ttaatcttgg cgacattgac aatgatggct ttgaagatgt     1920

tgctatcgga gctccacaag aagatgactt gcaaggtgct atttatattt acaatggccg     1980

tgcagatggg atctcgtcaa ccttctcaca gagaattgaa ggacttcaga tcagcaaatc     2040

gttaagtatg tttggacagt ctatatcagg acaaattgat gcagataata atggctatgt     2100

agatgtagca gttggtgctt ttcggtctga ttctgctgtc ttgctaagga caagacctgt     2160

agtaattgtt gacgcttctt taagccaccc tgagtcagta aatagaacga aatttgactg     2220

tgttgaaaat ggatggcctt ctgtgtgcat agatctaaca ctttgtttct catataaggg     2280

caaggaagtt ccaggttaca ttgttttgtt ttataacatg agtttggatg tgaacagaaa     2340

ggcagagtct ccaccaagat tctatttctc ttctaatgga acttctgacg tgattacagg     2400

aagcatacag gtgtccagca gagaagctaa ctgtagaaca catcaagcat ttatgcggaa     2460

agatgtgcgg gacatcctca ccccaattca gattgaagct gcttaccacc ttggtcctca     2520

tgtcatcagt aaacgaagta cagaggaatt cccaccactt cagccaattc ttcagcagaa     2580

gaaagaaaaa gacataatga aaaaaacaat aaactttgca aggttttgtg cccatgaaaa     2640

ttgttctgct gatttacagg tttctgcaaa gattgggttt ttgaagcccc atgaaaataa     2700

aacatatctt gctgttggga gtatgaagac attgatgttg aatgtgtcct tgtttaatgc     2760

tggagatgat gcatatgaaa cgactctaca tgtcaaacta cccgtgggtc tttatttcat     2820

taagatttta gagctggaag agaagcaaat aaactgtgaa gtcacagata actctggcgt     2880

ggtacaactt gactgcagta ttggctatat atatgtagat catctctcaa ggatagatat     2940

tagctttctc ctggatgtga gctcactcag cagagcggaa gaggacctca gtatcacagt     3000

gcatgctacc tgtgaaaatg aagaggaaat ggacaatcta aagcacagca gagtgactgt     3060

agcaatacct ttaaaatatg aggttaagct gactgttcat gggtttgtaa acccaacttc     3120

atttgtgtat ggatcaaatg atgaaaatga gcctgaaacg tgcatggtgg agaaaatgaa     3180

cttaactttc catgttatca acactggcaa tagtatggct cccaatgtta gtgtggaaat     3240

aatggtacca aattctttta gcccccaaac tgataagctg ttcaacattt tggatgtcca     3300

gactactact ggagaatgcc actttgaaaa ttatcaaaga gtgtgtgcat tagagcagca     3360

aaagagtgca atgcagacct tgaaaggcat agtccggttc ttgtccaaga ctgataagag     3420

gctattgtac tgcataaaag ctgatccaca ttgtttaaat ttcttgtgta attttgggaa     3480

aatggaaagt ggaaaagaag ccagtgttca tatccaactg gaaggccggc catccatttt     3540

agaaatggat gagacttcag cactcaagtt tgaaataaga gcaacaggtt ttccagagcc     3600

aaatccaaga gtaattgaac taaacaagga tgagaatgtt gcgcatgttc tactggaagg     3660

actacatcat caaagaccca aacgttattt caccatagtg attatttcaa gtagcttgct     3720

acttggactt attgtacttc tgttgatctc atatgttatg tggaaggctg gcttctttaa     3780

aagacaatac aaatctatcc tacaagaaga aaacagaaga gacagttgga gttatatcaa     3840

cagtaaaagc aatgatgatt aaggacttct ttcaaattga gagaatggaa aacagactca     3900

ggttgtagta aagaaattta aaagacactg tttacaagaa aaaatgaatt ttgtttggac     3960

ttcttttact catgatcttg tgacatatta tgtcttcatg caaggggaaa atctcagcaa     4020

tgattactct ttgagataga agaactgcaa aggtaataat acagccaaag ataatctctc     4080

agcttttaaa tgggtagaga aacactaaag cattcaattt attcaagaaa agtaagccct     4140

tgaagatatc ttgaaatgaa agtataactg agttaaatta tactggagaa gtcttagact     4200

tgaaatacta cttaccatat gtgcttgcct cagtaaaatg aaccccactg ggtgggcaga     4260

ggttcatttc aaatacatct ttgatacttg ttcaaaatat gttctttaaa aatataattt     4320

tttagagagc tgttcccaaa ttttctaacg agtggaccat tatcacttta aagcccttta     4380

tttataatac atttcctacg ggctgtgttc caacaaccat tttttttcag cagactatga     4440

atattatagt attataggcc aaactggcaa acttcagact gaacatgtac actggtttga     4500

gcttagtgaa attacttctg gataattatt tttttataat tatggatttc accatctttc     4560

tttctgtata tatacatgtg tttttatgta ggtatatatt taccattctt cctatctatt     4620

cttcctataa cacaccttta tcaagcatac ccaggagtaa tcttcaaatc ttttgttata     4680

ttctgaaaca aaagattgtg agtgttgcac tttacctgat acacgctgat ttagaaaata     4740

cagaaaccat acctcactaa taactttaaa atcaaagctg tgcaaagact agggggccta     4800

tacttcatat gtattatgta ctatgtaaaa tattgactat cacacaacta tttccttgga     4860

tgtaattctt tgttaccctt tacaagtata agtgttacct tacatggaaa cgaagaaaca     4920

aaattcataa atttaaattc ataaatttag ctgaaagata ctgattcaat ttgtatacag     4980

tgaatataaa tgagacgaca gcaaaatttt catgaaatgt aaaatatttt tatagtttgt     5040

tcatactata tgaggttcta ttttaaatga ctttctggat tttaaaaaat ttctttaaat     5100

acaatcattt ttgtaatatt tattttatgc ttatgatcta gataattgca gaatatcatt     5160

ttatctgact ctgccttcat aagagagctg tggccgaatt ttgaacatct gttataggga     5220

gtgatcaaat tagaaggcaa tgtggaaaaa caattctggg aaagatttct ttatatgaag     5280

tccctgccac tagccagcca tcctaattga tgaaagttat ctgttcacag gcctgcagtg     5340

atggtgagga atgttctgag atttgcgaag gcatttgagt agtgaaatgt aagcacaaaa     5400

cctcctgaac ccagagtgtg tatacacagg aataaacttt atgacattta tgtattttta     5460

aaaaactttg tatcgttata aaaaggctag tcattctttc aggagaacat ctaggatcat     5520

agatgaaaaa tcaagccccg atttagaact gtcttctcca ggatggtctc taaggaaatt     5580

tacatttggt tctttcctac tcagaactac tcagaaacaa ctatatattt caggttatct     5640

gagcacagtg aaagcagagt actatggttg tccaacacag gcctctcaga tacaagggga     5700

acacaattac atattgggct agattttgcc cagttcaaaa tagtatttgt tatcaactta     5760

ctttgttact tgtatcatga attttaaaac cctaccactt taagaagaca gggatgggtt     5820

attctttttt ggcaggtagg ctatataact atgtgatttt gaaatttaac tgctctggat     5880

tagggagcag tgaatcaagg cagacttatg aaatctgtat tatatttgta acagaatata     5940

ggaaatttaa cataattgat gagctcaaat cctgaaaaat gaaagaatcc aaattatttc     6000

agaattatct aggttaaata ttgatgtatt atgatggttg caaagttttt ttgtgtgtcc     6060

aataaacaca ttgtaaaaaa aa                                              6082


<210>  40
<211>  1032
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ala Trp Glu Ala Arg Arg Glu Pro Gly Pro Arg Arg Ala Ala Val 
1               5                   10                  15      


Arg Glu Thr Val Met Leu Leu Leu Cys Leu Gly Val Pro Thr Gly Arg 
            20                  25                  30          


Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu Leu Tyr Gln Gly Pro His 
        35                  40                  45              


Asn Thr Leu Phe Gly Tyr Ser Val Val Leu His Ser His Gly Ala Asn 
    50                  55                  60                  


Arg Trp Leu Leu Val Gly Ala Pro Thr Ala Asn Trp Leu Ala Asn Ala 
65                  70                  75                  80  


Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg Cys Arg Ile Gly Lys Asn 
                85                  90                  95      


Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu Gly Ser Pro Asn Gly Glu 
            100                 105                 110         


Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg Asp Asn Gln Trp Leu Gly 
        115                 120                 125             


Val Thr Leu Ser Arg Gln Pro Gly Glu Asn Gly Ser Ile Val Thr Cys 
    130                 135                 140                 


Gly His Arg Trp Lys Asn Ile Phe Tyr Ile Lys Asn Glu Asn Lys Leu 
145                 150                 155                 160 


Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro Asp Leu Arg Thr Glu Leu 
                165                 170                 175     


Ser Lys Arg Ile Ala Pro Cys Tyr Gln Asp Tyr Val Lys Lys Phe Gly 
            180                 185                 190         


Glu Asn Phe Ala Ser Cys Gln Ala Gly Ile Ser Ser Phe Tyr Thr Lys 
        195                 200                 205             


Asp Leu Ile Val Met Gly Ala Pro Gly Ser Ser Tyr Trp Thr Gly Ser 
    210                 215                 220                 


Leu Phe Val Tyr Asn Ile Thr Thr Asn Lys Tyr Lys Ala Phe Leu Asp 
225                 230                 235                 240 


Lys Gln Asn Gln Val Lys Phe Gly Ser Tyr Leu Gly Tyr Ser Val Gly 
                245                 250                 255     


Ala Gly His Phe Arg Ser Gln His Thr Thr Glu Val Val Gly Gly Ala 
            260                 265                 270         


Pro Gln His Glu Gln Ile Gly Lys Ala Tyr Ile Phe Ser Ile Asp Glu 
        275                 280                 285             


Lys Glu Leu Asn Ile Leu His Glu Met Lys Gly Lys Lys Leu Gly Ser 
    290                 295                 300                 


Tyr Phe Gly Ala Ser Val Cys Ala Val Asp Leu Asn Ala Asp Gly Phe 
305                 310                 315                 320 


Ser Asp Leu Leu Val Gly Ala Pro Met Gln Ser Thr Ile Arg Glu Glu 
                325                 330                 335     


Gly Arg Val Phe Val Tyr Ile Asn Ser Gly Ser Gly Ala Val Met Asn 
            340                 345                 350         


Ala Met Glu Thr Asn Leu Val Gly Ser Asp Lys Tyr Ala Ala Arg Phe 
        355                 360                 365             


Gly Glu Ser Ile Val Asn Leu Gly Asp Ile Asp Asn Asp Gly Phe Glu 
    370                 375                 380                 


Asp Val Ala Ile Gly Ala Pro Gln Glu Asp Asp Leu Gln Gly Ala Ile 
385                 390                 395                 400 


Tyr Ile Tyr Asn Gly Arg Ala Asp Gly Ile Ser Ser Thr Phe Ser Gln 
                405                 410                 415     


Arg Ile Glu Gly Leu Gln Ile Ser Lys Ser Leu Ser Met Phe Gly Gln 
            420                 425                 430         


Ser Ile Ser Gly Gln Ile Asp Ala Asp Asn Asn Gly Tyr Val Asp Val 
        435                 440                 445             


Ala Val Gly Ala Phe Arg Ser Asp Ser Ala Val Leu Leu Arg Thr Arg 
    450                 455                 460                 


Pro Val Val Ile Val Asp Ala Ser Leu Ser His Pro Glu Ser Val Asn 
465                 470                 475                 480 


Arg Thr Lys Phe Asp Cys Val Glu Asn Gly Trp Pro Ser Val Cys Ile 
                485                 490                 495     


Asp Leu Thr Leu Cys Phe Ser Tyr Lys Gly Lys Glu Val Pro Gly Tyr 
            500                 505                 510         


Ile Val Leu Phe Tyr Asn Met Ser Leu Asp Val Asn Arg Lys Ala Glu 
        515                 520                 525             


Ser Pro Pro Arg Phe Tyr Phe Ser Ser Asn Gly Thr Ser Asp Val Ile 
    530                 535                 540                 


Thr Gly Ser Ile Gln Val Ser Ser Arg Glu Ala Asn Cys Arg Thr His 
545                 550                 555                 560 


Gln Ala Phe Met Arg Lys Asp Val Arg Asp Ile Leu Thr Pro Ile Gln 
                565                 570                 575     


Ile Glu Ala Ala Tyr His Leu Gly Pro His Val Ile Ser Lys Arg Ser 
            580                 585                 590         


Thr Glu Glu Phe Pro Pro Leu Gln Pro Ile Leu Gln Gln Lys Lys Glu 
        595                 600                 605             


Lys Asp Ile Met Lys Lys Thr Ile Asn Phe Ala Arg Phe Cys Ala His 
    610                 615                 620                 


Glu Asn Cys Ser Ala Asp Leu Gln Val Ser Ala Lys Ile Gly Phe Leu 
625                 630                 635                 640 


Lys Pro His Glu Asn Lys Thr Tyr Leu Ala Val Gly Ser Met Lys Thr 
                645                 650                 655     


Leu Met Leu Asn Val Ser Leu Phe Asn Ala Gly Asp Asp Ala Tyr Glu 
            660                 665                 670         


Thr Thr Leu His Val Lys Leu Pro Val Gly Leu Tyr Phe Ile Lys Ile 
        675                 680                 685             


Leu Glu Leu Glu Glu Lys Gln Ile Asn Cys Glu Val Thr Asp Asn Ser 
    690                 695                 700                 


Gly Val Val Gln Leu Asp Cys Ser Ile Gly Tyr Ile Tyr Val Asp His 
705                 710                 715                 720 


Leu Ser Arg Ile Asp Ile Ser Phe Leu Leu Asp Val Ser Ser Leu Ser 
                725                 730                 735     


Arg Ala Glu Glu Asp Leu Ser Ile Thr Val His Ala Thr Cys Glu Asn 
            740                 745                 750         


Glu Glu Glu Met Asp Asn Leu Lys His Ser Arg Val Thr Val Ala Ile 
        755                 760                 765             


Pro Leu Lys Tyr Glu Val Lys Leu Thr Val His Gly Phe Val Asn Pro 
    770                 775                 780                 


Thr Ser Phe Val Tyr Gly Ser Asn Asp Glu Asn Glu Pro Glu Thr Cys 
785                 790                 795                 800 


Met Val Glu Lys Met Asn Leu Thr Phe His Val Ile Asn Thr Gly Asn 
                805                 810                 815     


Ser Met Ala Pro Asn Val Ser Val Glu Ile Met Val Pro Asn Ser Phe 
            820                 825                 830         


Ser Pro Gln Thr Asp Lys Leu Phe Asn Ile Leu Asp Val Gln Thr Thr 
        835                 840                 845             


Thr Gly Glu Cys His Phe Glu Asn Tyr Gln Arg Val Cys Ala Leu Glu 
    850                 855                 860                 


Gln Gln Lys Ser Ala Met Gln Thr Leu Lys Gly Ile Val Arg Phe Leu 
865                 870                 875                 880 


Ser Lys Thr Asp Lys Arg Leu Leu Tyr Cys Ile Lys Ala Asp Pro His 
                885                 890                 895     


Cys Leu Asn Phe Leu Cys Asn Phe Gly Lys Met Glu Ser Gly Lys Glu 
            900                 905                 910         


Ala Ser Val His Ile Gln Leu Glu Gly Arg Pro Ser Ile Leu Glu Met 
        915                 920                 925             


Asp Glu Thr Ser Ala Leu Lys Phe Glu Ile Arg Ala Thr Gly Phe Pro 
    930                 935                 940                 


Glu Pro Asn Pro Arg Val Ile Glu Leu Asn Lys Asp Glu Asn Val Ala 
945                 950                 955                 960 


His Val Leu Leu Glu Gly Leu His His Gln Arg Pro Lys Arg Tyr Phe 
                965                 970                 975     


Thr Ile Val Ile Ile Ser Ser Ser Leu Leu Leu Gly Leu Ile Val Leu 
            980                 985                 990         


Leu Leu Ile Ser Tyr Val Met Trp  Lys Ala Gly Phe Phe  Lys Arg Gln 
        995                 1000                 1005             


Tyr Lys  Ser Ile Leu Gln Glu  Glu Asn Arg Arg Asp  Ser Trp Ser 
    1010                 1015                 1020             


Tyr Ile  Asn Ser Lys Ser Asn  Asp Asp 
    1025                 1030         


<210>  41
<211>  3166
<212>  DNA
<213>  Homo sapiens

<400>  41
gaaaagcgct ggaataccag gagaaaatag tctttcaaaa ggtagggcac catcaacacc       60

ttcgcgacag gattaagagt ttctagattc ccaaaggtcc aggctgatag gtgagaggag      120

caactttaag agctgctaga gactgagttg aaacgtttac gccagaaaga cgtttggcta      180

aggagctatg gagccgggaa agggaagagc tcagcggaca aggcaagtgc tgcttttctt      240

tgttttcctg ggagggtctt tggtgtgttc tgagaccggg agctattcca tagcagagga      300

aatggaggtc ggtaccttta tagccaacgt ggtgaaagac atgggtttgg atgtggaaga      360

cctggctgca agggggggcc agagtcatct ttgacgacta taaaccttat ttgcgattgg      420

atccacagaa tggcgacttg ctcttaaacg agcagctgga ccgggaggca ctttgtgatc      480

tcacagagcc atgtatattg catttccagg tgttatttga aaatccgttg caattttttc      540

gtgctgagct tttggtcaaa gacataaatg atcacactcc cacgttccta aacaatcata      600

tgcttctaaa aatctccgaa ggtgctactc taggaacctt attccaaata gatagtgcgc      660

aggacttgga tgtgggaaag aatggtgttc aaaactatac aataagtccc aatccccatt      720

tccaccttaa attacgggat agcgatgagg gcagaaaata tccagagttg gtactggacc      780

aatccctgga tcgagaaaag gtgtctgagt ttagtttaac gctaacagcc gtggatggcg      840

ggtctccgcc caggtctggg actacactga ttaacgttgt ggtcctggac atcagtgaca      900

atgcccctga atttgagaag ccagtctatg aagttcatgt acctgagagc agccctctgg      960

actccttgat catcaaagcg tctgctacag atttagatgc aggaataaat ggagaactgt     1020

cttattcatt ttcccacgtc tccagagatg tacggaaaac atttgaaatc catccaattt     1080

ctggcgaagt ctatttaaaa gcccctctag atttcgagat tattcaatct tatatcataa     1140

atattcaggc cattgaaggt gggagccttt ctggaaaatc aagcatttta gttcgggttg     1200

tagatgtgaa tgacaacccg ccagaaatag ccatgacatc tcttaccagc cccataccgg     1260

aaaactcttc acctgagatg gtggtcgctg ttttcagcat acgagaccaa gacgctggag     1320

acaatgggag aacagtttgc tcaattcagg acaacctccc ctttgtcttg aagcctacct     1380

tcaagaattt ttacgctctg gtaacagagc acccactgga cagagaggtc agaaatgaat     1440

ataacatcac catcaccgtg accgacttgg ggacacccag gctgaaaacc gagcacaaca     1500

taaccgtgct ggtctccgac gtcaatgaca acgcccccat cttcacccaa acctcctaca     1560

ccctgttcgt ccgcgagaac aacagccccg ccctgcacat cggcagcgtc agcgctacag     1620

acagagactc aggcaccaac gcccaggtca cctactcgct gctgccgccc caggacccgc     1680

acctgcccct cacctccctg gtctccatca acgcggacaa cggccaccta ttcgccctca     1740

ggtctttgga ctacgaggcc ctgcaggagt tcgggtttcg cgtgggcgcc gcagaccacg     1800

gctccccggc gctgagcagc gaggtgctgg tgcgcgtgct ggtgctggac gccaacgaca     1860

actcgccctt cgtgctgtac ccgctgcaga acggctcggc gccctgcacc gagctggtac     1920

ctcgggcggc cgagccgggc tacctggtga ccaaggtggt ggcggtggac ggcgactcgg     1980

gccagaacgc ctggctgtcg taccagctgc tcaaggccac ggagcccggg ctgttcggcg     2040

tgtgggcgca caatggcgag gggcgcaccg ccaggctgct gagcgagcgc gacgcggcca     2100

agcacaggct ggtggtgctg gtcaaggaca atggcgagcc tccgcgctcg gccaccgcca     2160

cgctgcacgt gctcctggtg gagggcttct ctcagcccta cctgcctctc acggaggctg     2220

ccccctccca ggcccaggcc gactccctca ccgtctacct ggtggtggcg ttggcctcgg     2280

tgtcgtcgct cttcctcttc tcggtgttcc tgttcgtggc ggtgcggctg tgcaggagga     2340

gcagggcggc ctcgatgggt cgctgctcgg tgcccgagtg tccctttcca gggcatctgg     2400

tagacgtgag cggcaccggg accctatccc agagctacca gtacgaggtg tgtctgacgg     2460

gaggctcagg ggcaaatgag ttcaagttcc tgaagccggt gattcccaat ctcctgtccc     2520

gcgacagcga aatggagaaa gccccacctt tctgaatggc gtggaatgca attagggatc     2580

tgattatgat gcagaacttt tagaatgagt ctatttcttt gaaatcttat tcattgttat     2640

gcagagtttt tcattttggg taactgcatt ttactcaaga gttttcagaa gttacaagaa     2700

tttaagtcta ttttttgttg ttttaaccgt gaaaaaattg agagccggaa tttgcttagt     2760

cattgttttg aaatacaacc tcaaataata tattcacaaa cacattattt tcccttcaag     2820

tttaatcgca cactgggctc attcatattt tctgagtgtt ctgactgtgg atcctctatc     2880

caaagcagtt tttatataat tgagaatatt attatagagg taaatgcatg atatgaataa     2940

aaacataatt gcttgttatc tggttaggtt ggtttctgag atgttatcta atttaggttt     3000

ctttcttaaa aacctataat cttttcattc tacttttctg gcaaacattg cagagaattt     3060

ttcctgtact tagggttttt tttccataat tatttgtgaa ccatatatat gctagtagaa     3120

gttgttttat ttaaataaat tcaaaacctt gtttggatta agatgt                    3166


<210>  42
<211>  734
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Trp Lys Thr Trp Leu Gln Gly Gly Ala Arg Val Ile Phe Asp Asp 
1               5                   10                  15      


Tyr Lys Pro Tyr Leu Arg Leu Asp Pro Gln Asn Gly Asp Leu Leu Leu 
            20                  25                  30          


Asn Glu Gln Leu Asp Arg Glu Ala Leu Cys Asp Leu Thr Glu Pro Cys 
        35                  40                  45              


Ile Leu His Phe Gln Val Leu Phe Glu Asn Pro Leu Gln Phe Phe Arg 
    50                  55                  60                  


Ala Glu Leu Leu Val Lys Asp Ile Asn Asp His Thr Pro Thr Phe Leu 
65                  70                  75                  80  


Asn Asn His Met Leu Leu Lys Ile Ser Glu Gly Ala Thr Leu Gly Thr 
                85                  90                  95      


Leu Phe Gln Ile Asp Ser Ala Gln Asp Leu Asp Val Gly Lys Asn Gly 
            100                 105                 110         


Val Gln Asn Tyr Thr Ile Ser Pro Asn Pro His Phe His Leu Lys Leu 
        115                 120                 125             


Arg Asp Ser Asp Glu Gly Arg Lys Tyr Pro Glu Leu Val Leu Asp Gln 
    130                 135                 140                 


Ser Leu Asp Arg Glu Lys Val Ser Glu Phe Ser Leu Thr Leu Thr Ala 
145                 150                 155                 160 


Val Asp Gly Gly Ser Pro Pro Arg Ser Gly Thr Thr Leu Ile Asn Val 
                165                 170                 175     


Val Val Leu Asp Ile Ser Asp Asn Ala Pro Glu Phe Glu Lys Pro Val 
            180                 185                 190         


Tyr Glu Val His Val Pro Glu Ser Ser Pro Leu Asp Ser Leu Ile Ile 
        195                 200                 205             


Lys Ala Ser Ala Thr Asp Leu Asp Ala Gly Ile Asn Gly Glu Leu Ser 
    210                 215                 220                 


Tyr Ser Phe Ser His Val Ser Arg Asp Val Arg Lys Thr Phe Glu Ile 
225                 230                 235                 240 


His Pro Ile Ser Gly Glu Val Tyr Leu Lys Ala Pro Leu Asp Phe Glu 
                245                 250                 255     


Ile Ile Gln Ser Tyr Ile Ile Asn Ile Gln Ala Ile Glu Gly Gly Ser 
            260                 265                 270         


Leu Ser Gly Lys Ser Ser Ile Leu Val Arg Val Val Asp Val Asn Asp 
        275                 280                 285             


Asn Pro Pro Glu Ile Ala Met Thr Ser Leu Thr Ser Pro Ile Pro Glu 
    290                 295                 300                 


Asn Ser Ser Pro Glu Met Val Val Ala Val Phe Ser Ile Arg Asp Gln 
305                 310                 315                 320 


Asp Ala Gly Asp Asn Gly Arg Thr Val Cys Ser Ile Gln Asp Asn Leu 
                325                 330                 335     


Pro Phe Val Leu Lys Pro Thr Phe Lys Asn Phe Tyr Ala Leu Val Thr 
            340                 345                 350         


Glu His Pro Leu Asp Arg Glu Val Arg Asn Glu Tyr Asn Ile Thr Ile 
        355                 360                 365             


Thr Val Thr Asp Leu Gly Thr Pro Arg Leu Lys Thr Glu His Asn Ile 
    370                 375                 380                 


Thr Val Leu Val Ser Asp Val Asn Asp Asn Ala Pro Ile Phe Thr Gln 
385                 390                 395                 400 


Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn Ser Pro Ala Leu His 
                405                 410                 415     


Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser Gly Thr Asn Ala Gln 
            420                 425                 430         


Val Thr Tyr Ser Leu Leu Pro Pro Gln Asp Pro His Leu Pro Leu Thr 
        435                 440                 445             


Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His Leu Phe Ala Leu Arg 
    450                 455                 460                 


Ser Leu Asp Tyr Glu Ala Leu Gln Glu Phe Gly Phe Arg Val Gly Ala 
465                 470                 475                 480 


Ala Asp His Gly Ser Pro Ala Leu Ser Ser Glu Val Leu Val Arg Val 
                485                 490                 495     


Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe Val Leu Tyr Pro Leu 
            500                 505                 510         


Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val Pro Arg Ala Ala Glu 
        515                 520                 525             


Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val Asp Gly Asp Ser Gly 
    530                 535                 540                 


Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys Ala Thr Glu Pro Gly 
545                 550                 555                 560 


Leu Phe Gly Val Trp Ala His Asn Gly Glu Gly Arg Thr Ala Arg Leu 
                565                 570                 575     


Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu Val Val Leu Val Lys 
            580                 585                 590         


Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala Thr Leu His Val Leu 
        595                 600                 605             


Leu Val Glu Gly Phe Ser Gln Pro Tyr Leu Pro Leu Thr Glu Ala Ala 
    610                 615                 620                 


Pro Ser Gln Ala Gln Ala Asp Ser Leu Thr Val Tyr Leu Val Val Ala 
625                 630                 635                 640 


Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser Val Phe Leu Phe Val 
                645                 650                 655     


Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala Ser Met Gly Arg Cys 
            660                 665                 670         


Ser Val Pro Glu Cys Pro Phe Pro Gly His Leu Val Asp Val Ser Gly 
        675                 680                 685             


Thr Gly Thr Leu Ser Gln Ser Tyr Gln Tyr Glu Val Cys Leu Thr Gly 
    690                 695                 700                 


Gly Ser Gly Ala Asn Glu Phe Lys Phe Leu Lys Pro Val Ile Pro Asn 
705                 710                 715                 720 


Leu Leu Ser Arg Asp Ser Glu Met Glu Lys Ala Pro Pro Phe 
                725                 730                 


<210>  43
<211>  2213
<212>  DNA
<213>  Homo sapiens

<400>  43
gcgggactcg gccttctggg cgcgcgcgac gtcagtttga gttctgtgtt ctccccgccc       60

gtgtcccgcc cgacccgcgc ccgcgatgct ggcgctgcgc tgcggctccc gctggctcgg      120

cctgctctcc gtcccgcgct ccgtgccgct gcgcctcccc gcggcccgcg cctgcagcaa      180

gggctccggc gacccgtcct cttcctcctc ctccgggaac ccgctcgtgt acctggacgt      240

ggacgccaac gggaagccgc tcggccgcgt ggtgctggag ctgaaggcag atgtcgtccc      300

aaagacagct gagaacttca gagccctgtg cactggtgag aagggcttcg gctacaaagg      360

ctccaccttc cacagggtga tcccttcctt catgtgccag gcgggcgact tcaccaacca      420

caatggcaca ggcgggaagt ccatctacgg aagccgcttt cctgacgaga actttacact      480

gaagcacgtg gggccaggtg tcctgtccat ggctaatgct ggtcctaaca ccaacggctc      540

ccagttcttc atctgcacca taaagacaga ctggttggat ggcaagcatg ttgtgttcgg      600

tcacgtcaaa gagggcatgg acgtcgtgaa gaaaatagaa tctttcggct ctaagagtgg      660

gaggacatcc aagaagattg tcatcacaga ctgtggccag ttgagctaat ctgtggccag      720

ggtgctggca tggtggcagc tgcaaatgtc catgcaccca ggtggccgcg ttgggctgtc      780

agccaaggtg cctgaaacga tacgtgtgcc cactccactg tcacagtgtg cctgaggaag      840

gctgctaggg atgttagacc tcggccagga cccaccacat tgcttcctaa tacccaccct      900

tcctcacgac ctcatttctg ggcatctttg tggacatgat gtcacccacc ccttgtcaag      960

cattgcctgt gattgcccag cccagattca tctgtgcctt ggacatggtg atggtgatgg     1020

gttgccatcc aagtgaaagt cttttccttg accaaggggg acagtcagtt ttgcaaaagg     1080

actctaatac ctgtttaata ttgtcttcct aattgggata atttaattaa caagattgac     1140

tagaagtgaa actgcaacac taacttcccc gtgctgtggt gtgacctgag ttggtgacac     1200

aggccacaga ccccagagct tggcttttga aacacaactc agggcttttg tgaaggttcc     1260

cccgctgaga tctttcctcc tggttactgt gaagcctgtt ggtttgctgc tgtcgttttt     1320

gaggagggcc catgggggta ggagcagttg aacctgggaa caaacctcac ttgagctgtg     1380

cctagacaat gtgaattcct gtgttgctaa cagaagtggc ctgtaagctc ctgtgctccg     1440

gagggaagca tttcctggta ggctttgatt tttctgtgtg ttaaagaaat tcaatctact     1500

catgatgtgt tatgcataaa acatttctgg aacatggatt tgtgttcacc ttaaatgtga     1560

aaataaatcc tattttctat ggaagactgg tacctggttt ctggaagagg ggtctgtgac     1620

ttggagctga tctttactga gctcgccgtg gcagatgcca tgctcaggac gttcatgtgg     1680

atggtttcat gtcatcgtgc tggcaacttg tcctccctgc cttagagatg aggctcagac     1740

aaacgacctt agcacccata gcctatgcca tgagcactgg ctccaccctg aatcccagct     1800

cctcccctta gtgaccccaa gtctgtttcc ctcagctgca taaggaggcg atatagtttg     1860

aatatttgtc cccagccaaa tctcatgttg aactgtaatc cccagtgctg gaggtggggc     1920

ctgctacgag gtgtttggat catggggacg ggtatttcat ggcttggtgc tgttttcttg     1980

atggtgaatt attgcaagat acggtcattt aaaattgtgt ggcacctccc cctgccccct     2040

tcttgctcct gctttcacca tgtgacatgc ctgatccccc ttcacctttt gccatggtca     2100

taagcttcct gaggcctccc tggaagctga gcagatgcca gcaccatgct tcctgtacat     2160

cctgcagaac cataagccaa ttaaaccttt ttaataataa aaaaaaaaaa aaa            2213


<210>  44
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Leu Ala Leu Arg Cys Gly Ser Arg Trp Leu Gly Leu Leu Ser Val 
1               5                   10                  15      


Pro Arg Ser Val Pro Leu Arg Leu Pro Ala Ala Arg Ala Cys Ser Lys 
            20                  25                  30          


Gly Ser Gly Asp Pro Ser Ser Ser Ser Ser Ser Gly Asn Pro Leu Val 
        35                  40                  45              


Tyr Leu Asp Val Asp Ala Asn Gly Lys Pro Leu Gly Arg Val Val Leu 
    50                  55                  60                  


Glu Leu Lys Ala Asp Val Val Pro Lys Thr Ala Glu Asn Phe Arg Ala 
65                  70                  75                  80  


Leu Cys Thr Gly Glu Lys Gly Phe Gly Tyr Lys Gly Ser Thr Phe His 
                85                  90                  95      


Arg Val Ile Pro Ser Phe Met Cys Gln Ala Gly Asp Phe Thr Asn His 
            100                 105                 110         


Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly Ser Arg Phe Pro Asp Glu 
        115                 120                 125             


Asn Phe Thr Leu Lys His Val Gly Pro Gly Val Leu Ser Met Ala Asn 
    130                 135                 140                 


Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe Ile Cys Thr Ile Lys 
145                 150                 155                 160 


Thr Asp Trp Leu Asp Gly Lys His Val Val Phe Gly His Val Lys Glu 
                165                 170                 175     


Gly Met Asp Val Val Lys Lys Ile Glu Ser Phe Gly Ser Lys Ser Gly 
            180                 185                 190         


Arg Thr Ser Lys Lys Ile Val Ile Thr Asp Cys Gly Gln Leu Ser 
        195                 200                 205         


<210>  45
<211>  4386
<212>  DNA
<213>  Homo sapiens

<400>  45
gggctccacg gagtgaatag gaggcggctc aggcttcctg gctcgcgtgg gcgccagaaa       60

gcggaacctc ccgggccagt cgcgcggtgg tcaccctctt gggagctggg gaggaggctg      120

cggaggctgg cccggctcct tcgggcgtcg cttcccggac cgggtgcgcg gggtcccccg      180

gaacgtgtgt tccaggtcct cccgcgccag tgttcgcagt ccccgcctgg tcgcggcggc      240

gcctcgggcg cgggtgcagg cgcgcggcgc gcaggcgggg ggcgctgtgg tcttggcgcg      300

gggaccgagc cgctcggcca gacccgcctc ttttccctcc ccgccagccc gcccgcctgc      360

ccgcccccca cgcgtcgtgt cgccgggaag ccgggcggag acagagcgct tgggatccac      420

ggcgctcgga ccgctgtcct ccaacagcgc agggcagagc ggctggcgcc gccggagcgc      480

ggagccacga ccctccctgg ccgcctttgt ctactggccg tgcggcccgg aaccgccact      540

ctccagggcc ggggacgcgc ccgcagctgt cggtgacagc tcctccctac cgcaaccctc      600

cggggcggag gggcggtcgg gccgggccct gctagcccgc gaccgcaagc ccgcgctcgc      660

ggatcgatgc ccccgcagca gggggacccc gcgttccccg accgctgcga ggcgcctccg      720

gtgccgccgc gtcgggagcg cggtggacgc gggggacgcg ggcctgggga gccggggggc      780

cgggggcgtg cggggggtgc cgaggggcgc ggcgtcaagt gcgtgctggt cggcgacggc      840

gcggtgggca agacgagcct ggtggtgagc tacaccacca acggctaccc caccgagtac      900

atccctactg ccttcgacaa cttctccgcg gtggtgtctg tggatgggcg gcccgtgaga      960

ctccaactct gtgacactgc cggacaggat gaatttgaca agctgaggcc tctctgctac     1020

accaacacag acatcttcct gctctgcttc agtgtcgtga gcccctcatc cttccagaac     1080

gtcagtgaga aatgggtgcc ggagattcga tgccactgtc ccaaagcccc catcatccta     1140

gttggaacgc agtcggatct cagagaagat gtcaaagtcc tcattgagtt ggacaaatgc     1200

aaagaaaagc cagtgcctga agaggcggct aagctgtgcg ccgaggaaat caaagccgcc     1260

tcctacatcg agtgttcagc cttgactcaa aaaaacctca aagaggtctt tgatgcagcc     1320

atcgtcgctg gcattcaata ctcggacact cagcaacagc caaagaagtc taaaagcagg     1380

actccagata aaatgaaaaa cctctccaag tcctggtgga agaagtactg ctgtttcgta     1440

tgatgctggc aagacaccca gaaaggctat tttcagatga aatcgatatt agaagctata     1500

ttagctgaaa caactccttt tactgcgtag aacctatatc gagagtgtgt gtatatgtat     1560

tataggagga gctctcaatt ttatgtattc tttctgcctt taattttctt gtttgtttga     1620

gcttagggat gagatactta tgcaagatat ttttgaagta aattaaacat ttttcacatc     1680

tctggaaatt tagagttcta gacctctggt taatttatat ctaatatgaa gaagacacct     1740

ctaatctgga tgttaagaat gaagttctgc tacattataa tgtacagaag agcaaaaggg     1800

aggaacacta tggttaaccc tctcttgatt aagggctact taatgcacag tgcattatgt     1860

acacaggtca accatggtaa caatagttct tagctttgaa actccatgca aaccatgcct     1920

tttttttaag gagcaaaaat ctgagaaaaa aagtgagaga cctctgccta caaaacctca     1980

aaccagtcac ttttgtcaat tgctaatacc cagttactta tgatttaaaa acaaccaaca     2040

gaaaacatcc cactgactgt atggcactct gtagtcaaaa aaggaaactt ccttattggg     2100

acttttcttt cttagtccag ttgtgttgac acatatgaac acagacaaag tgctatgcgg     2160

aggaaagcaa gtgttggtca gtagtttcat gttttaggga gtggttcctg tggagatcag     2220

aaagtgacat ttgctttcgg tactgtaata cgtgcaccaa actgcctcaa tcctaggtaa     2280

cgagggcaac agggagcacc tgtctggatt gtttttaaac ctccatactc aagctgtctc     2340

ttcggcaggg aggtgaatac tcttgaaagg ccaacagcaa gtgtttgtgg gacacaacac     2400

agataatttt ttcttaagtc ggccaagatg tacttctctg tgtgcacacc catgcacact     2460

catgcacaca gatacatagg tctgtatggc tgtatttgct gttgattcag actttcacac     2520

cattaatggg gaaaagcgtg gccacaaaaa cagatgctag gaagcttggc ttcctcttct     2580

tgttgaccct tttttgaacc aacatctttt ttattatatt cagagtatgt ttttaagtgt     2640

atcttaatat atacattttt taggacatct taaatctaaa caaaaaataa aatgaacatc     2700

tcttgaaacc tgttaaaaca accagttaaa gccacagatg gctttcaggg cagtagcagc     2760

agaggccagt ggactctgag gactcctgag gggcggggcg tgtagccagc caggtgcatg     2820

ccgggaccat ggcccccata cttggctgct tcctgtgaca gtgaaataca tccttcaagg     2880

tggcagctgt tagggctgaa tcttctggag aaaaaggtgc catctcagga gaatagcttt     2940

tactctggta ggaatgcttc cgagacacca caaggcagcc tgaacactca gttgcagggt     3000

cgggcttgcg gtgggtgacc cagagccacc aaagtcacat ccacaactaa tgagggaaat     3060

ctgtaaagcc agttagatag aagaatttta tttttctgtg ggttttgtgt tgtctttttt     3120

atgttaaaaa gaaatccagt ttgtgttttt ctatagaaaa agtaaaagat caggttatac     3180

tttaggttag gggttctatt tattcctgtt agtaaataaa attaacaaat ttctttgttt     3240

aacaaaagat taatctttaa accactaaaa tacatagact gattgattat tcaacacatt     3300

ggaattgatg tcggtcatag tttcctgaag catttagtta caacctgaag gaataaaatg     3360

atttgtggaa atgcttaaaa tagacctaac tgaatacagt ctcatcttgc cgcgcctggc     3420

ttacctatct gtggaaagct aggcttccca ggctgggctc tgcctgtctg gtgcctggag     3480

gtgtgggagg gaagatgagt tatttaactg gtaagcgatt tgaaacacta tttttatatt     3540

aaagtaaatg gcatggagta tagtgcaaat tcatttttaa gatagaacac aaaacttgaa     3600

agaagtttta tgcgtgtgac agtgtatggg gctgcagttg gtctccctgg aggggacttc     3660

cacacctcct gcctttaggc catgggtgga aagtgctcag tgaagtacac ctgtgtggcc     3720

cagttctgaa agctttatac agttgaattt taagtggggt tgataacacc ttggactgtt     3780

agtgttaaaa atctagtggg ttgaccttta aatgcaacag tttttaaaat atattgctgc     3840

attttataga atagtaaagg tacgattata cttgagattt tcctccattt ttatttcttc     3900

gtgaacatag agtttggggc cgaaaatgtt tttaaagtat gtgtttgagt taaatataaa     3960

gttggttcac ttcaaagcta aaaaattgtt aaacttgcag cttggtattg cagagaagat     4020

tttataagaa ttttgcttta gagaatgcca ctttggctga actacaagtg taggccacca     4080

ttataattta taaatacagc atacttcaaa actgtttgtt atctcttgtt accatgtatg     4140

tataaatgga ccttttataa ccttgttctc tgcttgacag actcaagaga aactacccag     4200

gtattacaca agccaaaatg ggagcaaggc cttctctcca gactatcgta acctggtgcc     4260

ttaccaagtt gtgcttttct gttttcaagt gtaaatgatg ttgagcagaa tgttgtactt     4320

gaaaatgcta taagtgagat ggtatgaaat aaattctgac ttatgaatat aaaaaaaaaa     4380

aaaaaa                                                                4386


<210>  46
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Pro Pro Gln Gln Gly Asp Pro Ala Phe Pro Asp Arg Cys Glu Ala 
1               5                   10                  15      


Pro Pro Val Pro Pro Arg Arg Glu Arg Gly Gly Arg Gly Gly Arg Gly 
            20                  25                  30          


Pro Gly Glu Pro Gly Gly Arg Gly Arg Ala Gly Gly Ala Glu Gly Arg 
        35                  40                  45              


Gly Val Lys Cys Val Leu Val Gly Asp Gly Ala Val Gly Lys Thr Ser 
    50                  55                  60                  


Leu Val Val Ser Tyr Thr Thr Asn Gly Tyr Pro Thr Glu Tyr Ile Pro 
65                  70                  75                  80  


Thr Ala Phe Asp Asn Phe Ser Ala Val Val Ser Val Asp Gly Arg Pro 
                85                  90                  95      


Val Arg Leu Gln Leu Cys Asp Thr Ala Gly Gln Asp Glu Phe Asp Lys 
            100                 105                 110         


Leu Arg Pro Leu Cys Tyr Thr Asn Thr Asp Ile Phe Leu Leu Cys Phe 
        115                 120                 125             


Ser Val Val Ser Pro Ser Ser Phe Gln Asn Val Ser Glu Lys Trp Val 
    130                 135                 140                 


Pro Glu Ile Arg Cys His Cys Pro Lys Ala Pro Ile Ile Leu Val Gly 
145                 150                 155                 160 


Thr Gln Ser Asp Leu Arg Glu Asp Val Lys Val Leu Ile Glu Leu Asp 
                165                 170                 175     


Lys Cys Lys Glu Lys Pro Val Pro Glu Glu Ala Ala Lys Leu Cys Ala 
            180                 185                 190         


Glu Glu Ile Lys Ala Ala Ser Tyr Ile Glu Cys Ser Ala Leu Thr Gln 
        195                 200                 205             


Lys Asn Leu Lys Glu Val Phe Asp Ala Ala Ile Val Ala Gly Ile Gln 
    210                 215                 220                 


Tyr Ser Asp Thr Gln Gln Gln Pro Lys Lys Ser Lys Ser Arg Thr Pro 
225                 230                 235                 240 


Asp Lys Met Lys Asn Leu Ser Lys Ser Trp Trp Lys Lys Tyr Cys Cys 
                245                 250                 255     


Phe Val 
        


<210>  47
<211>  4469
<212>  DNA
<213>  Homo sapiens

<400>  47
acgtttgcag atgctctccc tgcgccgcga ccaccctgtg cttggcccag ttctcccgga       60

ggcgtccaga gactgggctc gtgccggggg acggaagagg gtgcgccccg gcggatccct      120

tcttggagcc tggacgtgag ctggccggtc cggggcttgc agacctccgg gaggagctgc      180

ggggctgagc ggcgaccagg aggccaggcc ggggcagagg accgccgagg gccaccgcgg      240

gaggcgcagt cagctgcgta caggcttgcg ccgccgcggg ccaagactcc aaattgggaa      300

aggggtggcc gcagctctgc gcatgtgcag gaggcgccgg agtttcactt tgtaactttt      360

aagtggtcgg aacacgcccc gcgctgctgg gtcccgccag acacgccgcc gccgcaggaa      420

agtctacagt ttggtacccc aggactcgct ggtcaggaaa gccctgcagg acatgagtgt      480

taggcccgac gcctggccct tggcagcttg ggaggtggct ggggctgctt ttgcctttgc      540

cagagacagc tccaactgag gacctctcca acgggcccat ccacagtcct tccttcccct      600

agtgtctggg aagacaggcg cgatgatgga ctccccgttc ctggagctgt ggcagtccaa      660

ggcagtgtcc atcagggagc agctgggact cggggaccgg cccaacgact cctattgcta      720

caactcggcc aaaaacagca ccgtgctcca gggggtcacc tttggtggca tccccactgt      780

cctgctcata gacgtcagct gcttcctgtt cttaatcttg gtgttttcta ttataagaag      840

aagattctgg gactatggcc gcattgccct ggtgtcagaa gcagacagcg agtccagatt      900

tcagagattg tcatcgactt cctcctcagg tcaacaagac tttgaaaatg agctgggatg      960

ctgtccctgg ctgactgcca tcttccgtct gcatgatgac cagatcctgg aatggtgtgg     1020

ggaggacgcc atccactacc tgtccttcca gaggcacatc atcttcctgt tggtggtggt     1080

cagctttttg tccctgtgtg tcatcctgcc tgtcaacctc tcaggggact tgctggacaa     1140

agacccgtat agttttggga ggacaacaat agcaaaccta cagactgaca atgacctcct     1200

ttggctgcac accatctttg ctgtcattta cctcttcctc actgtgggtt tcatgcggca     1260

ccacactcag tccattaagt acaaagagga gaacctggtg aggcggaccc tgttcatcac     1320

aggactcccc agagatgcca ggaaggagac tgtggagagc cacttccggg acgcgtatcc     1380

cacgtgtgag gtggttgatg tgcagctgtg ctacaacgtg gccaaactga tctacctgtg     1440

caaggagaaa aagaagactg agaagagcct gacctattac acaaacctgc aggtgaagac     1500

aggccagcgg accctcatca accccaagcc ctgtggccag ttttgctgct gtgaagtgct     1560

gggctgtgag tgggaagacg ccatctctta ctacacacgg atgaaggaca ggctgctgga     1620

gaggatcaca gaggaagaac gccacgtcca ggaccagccc ctgggaatgg ccttcgtcac     1680

cttccaggag aagtccatgg ccacctacat cctgaaagat ttcaatgcct gcaagtgtca     1740

gagccttcag tgcaaaggtg agccccagcc gtcctcccat agcagggagc tctatacctc     1800

caagtggaca gtcacctttg ctgctgaccc tgaggacatc tgctggaaga acctctctat     1860

ccagggcctc cgctggtggc tacagtggct gggcatcaac ttcaccctct tcctggggct     1920

atttttcctg accacaccct ccatcatcct gtccaccatg gacaagttta atgtcaccaa     1980

acccatccat gcgctgaata acccgatcat cagccagttc ttccccaccc tcctgctctg     2040

gtccttctcg gccctgctcc cctccattgt ctactactct acactgctgg agtctcactg     2100

gaccaagtcg ggggaaaacc agatcatgat gaccaaagtc tacatattct tgatcttcat     2160

ggtgctgatc ctgccctccc tgggtctcac cagtctagat tttttcttcc ggtggctctt     2220

tgacaaaact tcctcggagg cctccatcag gttggagtgc gtcttcctgc ctgaccaggg     2280

tgccttcttt gtgaactatg tcatcgcctc ggccttcatc ggcaatggca tggagctgct     2340

gcggctgcca ggtctcatcc tctatacctt ccgcatgatc atggccaaga cggctgctga     2400

ccgcaggaat gtcaagcaga accaggcctt ccagtacgag tttggagcca tgtatgcatg     2460

gatgctgtgt gtcttcactg tcatcgtggc ctacagcatc acttgtccca tcatcgcgcc     2520

atttggcctc atctacatcc tgctcaagca catggtggac cggcacaacc tctacttcgt     2580

ctacctccca gccaagctgg agaaggggat ccactttgcc gctgtgaacc aggccttggc     2640

agcccccatc ctgtgcctct tctggctcta cttcttttcc ttcctgcgcc tgggtatgaa     2700

ggcccccgcc actctgttca ccttcctggt gctgctgctc accatcctgg tctgcctggc     2760

tcacacctgc tttggatgct tcaagcacct cagccctctg aactacaaaa cagaagagcc     2820

tgcaagtgac aaaggaagtg aggcagaggc ccacatgccc ccaccgttca caccctacgt     2880

gcctcggatt ctgaacggct tggcctcgga gaggacagca ctgtctccgc agcagcagca     2940

gcagcagacc tatggtgcca tccacaacat cagcgggact atccctggac agtgcttggc     3000

gcagagcgcc acgggcagtg tggctgctgc cccccaggag gcctgaggct gggtctcact     3060

gctctgaaaa gacacaacca gaatggcctg gggctcaggc ccttggctga gtgggaatgc     3120

gttgggactg cccagctgag ctatcaggtg cccatctttt ctggtcccag cagtggtgag     3180

gagagcacag gcaggcctcg cccctccctt gctcacccag tttcccctcc ggcacaagct     3240

tccagctctg cagctggggt gacatcccca gtggtttgtc gccaagacca tgtggtggac     3300

ttttcgcccc ccaaactgat gagtccggga gaatatatgg agagagagat gtaacaaggg     3360

gaaggcctcc tcccttctga gcacacacac aaccgataac caaagagatg ctgcagtcca     3420

ggtctgaggt cccgctggca tccagctccc tgctccatgg ccagtccctc cccagcccag     3480

cagtccctcc aggctacatc caggagtaag ctatggggaa caggttggga ggtggccagt     3540

gctcctgcca gctgtgcaca catctctgta tcccgctaga gttctgtgtt tttgtatcat     3600

gttgtcaggg acgctagctg ggtcagggtt accccatagc aggcagggac aaggaccact     3660

cataatatgc ccattggacc acagttaaga tccagcctct ctcacctctt cagggctgag     3720

tgcatgagtc tgcacctcca ggcaggctct gtgcagtact caccccctcc gtctgctccc     3780

tccaaggtgt gggggtgggc agtgctcagg gcctcctcgg agccaaagga cagcatggtc     3840

ggcacagagg aaggggtacc tgggctgggt gcagggccat cccactgccc ttgagctgtg     3900

gctctggcag gaaggagggg cagcccatcc ctcttctccc tcctggggat tctggggaat     3960

gggatgcaac ttaagacttc tgcctgagaa gcctcctccc tgctgcctcc agggggcacc     4020

aaggcacaag cctgtgcagt aggggcggga tgggggtgtg gaagagcagg tccaggctcc     4080

tagcacaact ggcctggggc cttggcacct ctgtaggccc tgcctgtgcc tgtccgctgg     4140

cctggggggc ctgggcttat ctgggccttc tcactcaggg actctcttga cgctgacttg     4200

cccccgcagt ggtggccagt gctgcctctg ctccaagctg cccctgcgct gggaggggtg     4260

ggggcggtgc cattggtctg gtgcagcata gccctggcca gtggcctcat ccccagcagg     4320

cctcccgtgc ctctgccagc aaggaggggc cggccagctc tgcttgcaca gggggcccca     4380

tgtggggtca gcgcacgctc atgtcactga gttccagccg cttttagagt aaagtcgttt     4440

atcatcaaag ccaaaaaaaa aaaaaaaaa                                       4469


<210>  48
<211>  807
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Met Asp Ser Pro Phe Leu Glu Leu Trp Gln Ser Lys Ala Val Ser 
1               5                   10                  15      


Ile Arg Glu Gln Leu Gly Leu Gly Asp Arg Pro Asn Asp Ser Tyr Cys 
            20                  25                  30          


Tyr Asn Ser Ala Lys Asn Ser Thr Val Leu Gln Gly Val Thr Phe Gly 
        35                  40                  45              


Gly Ile Pro Thr Val Leu Leu Ile Asp Val Ser Cys Phe Leu Phe Leu 
    50                  55                  60                  


Ile Leu Val Phe Ser Ile Ile Arg Arg Arg Phe Trp Asp Tyr Gly Arg 
65                  70                  75                  80  


Ile Ala Leu Val Ser Glu Ala Asp Ser Glu Ser Arg Phe Gln Arg Leu 
                85                  90                  95      


Ser Ser Thr Ser Ser Ser Gly Gln Gln Asp Phe Glu Asn Glu Leu Gly 
            100                 105                 110         


Cys Cys Pro Trp Leu Thr Ala Ile Phe Arg Leu His Asp Asp Gln Ile 
        115                 120                 125             


Leu Glu Trp Cys Gly Glu Asp Ala Ile His Tyr Leu Ser Phe Gln Arg 
    130                 135                 140                 


His Ile Ile Phe Leu Leu Val Val Val Ser Phe Leu Ser Leu Cys Val 
145                 150                 155                 160 


Ile Leu Pro Val Asn Leu Ser Gly Asp Leu Leu Asp Lys Asp Pro Tyr 
                165                 170                 175     


Ser Phe Gly Arg Thr Thr Ile Ala Asn Leu Gln Thr Asp Asn Asp Leu 
            180                 185                 190         


Leu Trp Leu His Thr Ile Phe Ala Val Ile Tyr Leu Phe Leu Thr Val 
        195                 200                 205             


Gly Phe Met Arg His His Thr Gln Ser Ile Lys Tyr Lys Glu Glu Asn 
    210                 215                 220                 


Leu Val Arg Arg Thr Leu Phe Ile Thr Gly Leu Pro Arg Asp Ala Arg 
225                 230                 235                 240 


Lys Glu Thr Val Glu Ser His Phe Arg Asp Ala Tyr Pro Thr Cys Glu 
                245                 250                 255     


Val Val Asp Val Gln Leu Cys Tyr Asn Val Ala Lys Leu Ile Tyr Leu 
            260                 265                 270         


Cys Lys Glu Lys Lys Lys Thr Glu Lys Ser Leu Thr Tyr Tyr Thr Asn 
        275                 280                 285             


Leu Gln Val Lys Thr Gly Gln Arg Thr Leu Ile Asn Pro Lys Pro Cys 
    290                 295                 300                 


Gly Gln Phe Cys Cys Cys Glu Val Leu Gly Cys Glu Trp Glu Asp Ala 
305                 310                 315                 320 


Ile Ser Tyr Tyr Thr Arg Met Lys Asp Arg Leu Leu Glu Arg Ile Thr 
                325                 330                 335     


Glu Glu Glu Arg His Val Gln Asp Gln Pro Leu Gly Met Ala Phe Val 
            340                 345                 350         


Thr Phe Gln Glu Lys Ser Met Ala Thr Tyr Ile Leu Lys Asp Phe Asn 
        355                 360                 365             


Ala Cys Lys Cys Gln Ser Leu Gln Cys Lys Gly Glu Pro Gln Pro Ser 
    370                 375                 380                 


Ser His Ser Arg Glu Leu Tyr Thr Ser Lys Trp Thr Val Thr Phe Ala 
385                 390                 395                 400 


Ala Asp Pro Glu Asp Ile Cys Trp Lys Asn Leu Ser Ile Gln Gly Leu 
                405                 410                 415     


Arg Trp Trp Leu Gln Trp Leu Gly Ile Asn Phe Thr Leu Phe Leu Gly 
            420                 425                 430         


Leu Phe Phe Leu Thr Thr Pro Ser Ile Ile Leu Ser Thr Met Asp Lys 
        435                 440                 445             


Phe Asn Val Thr Lys Pro Ile His Ala Leu Asn Asn Pro Ile Ile Ser 
    450                 455                 460                 


Gln Phe Phe Pro Thr Leu Leu Leu Trp Ser Phe Ser Ala Leu Leu Pro 
465                 470                 475                 480 


Ser Ile Val Tyr Tyr Ser Thr Leu Leu Glu Ser His Trp Thr Lys Ser 
                485                 490                 495     


Gly Glu Asn Gln Ile Met Met Thr Lys Val Tyr Ile Phe Leu Ile Phe 
            500                 505                 510         


Met Val Leu Ile Leu Pro Ser Leu Gly Leu Thr Ser Leu Asp Phe Phe 
        515                 520                 525             


Phe Arg Trp Leu Phe Asp Lys Thr Ser Ser Glu Ala Ser Ile Arg Leu 
    530                 535                 540                 


Glu Cys Val Phe Leu Pro Asp Gln Gly Ala Phe Phe Val Asn Tyr Val 
545                 550                 555                 560 


Ile Ala Ser Ala Phe Ile Gly Asn Gly Met Glu Leu Leu Arg Leu Pro 
                565                 570                 575     


Gly Leu Ile Leu Tyr Thr Phe Arg Met Ile Met Ala Lys Thr Ala Ala 
            580                 585                 590         


Asp Arg Arg Asn Val Lys Gln Asn Gln Ala Phe Gln Tyr Glu Phe Gly 
        595                 600                 605             


Ala Met Tyr Ala Trp Met Leu Cys Val Phe Thr Val Ile Val Ala Tyr 
    610                 615                 620                 


Ser Ile Thr Cys Pro Ile Ile Ala Pro Phe Gly Leu Ile Tyr Ile Leu 
625                 630                 635                 640 


Leu Lys His Met Val Asp Arg His Asn Leu Tyr Phe Val Tyr Leu Pro 
                645                 650                 655     


Ala Lys Leu Glu Lys Gly Ile His Phe Ala Ala Val Asn Gln Ala Leu 
            660                 665                 670         


Ala Ala Pro Ile Leu Cys Leu Phe Trp Leu Tyr Phe Phe Ser Phe Leu 
        675                 680                 685             


Arg Leu Gly Met Lys Ala Pro Ala Thr Leu Phe Thr Phe Leu Val Leu 
    690                 695                 700                 


Leu Leu Thr Ile Leu Val Cys Leu Ala His Thr Cys Phe Gly Cys Phe 
705                 710                 715                 720 


Lys His Leu Ser Pro Leu Asn Tyr Lys Thr Glu Glu Pro Ala Ser Asp 
                725                 730                 735     


Lys Gly Ser Glu Ala Glu Ala His Met Pro Pro Pro Phe Thr Pro Tyr 
            740                 745                 750         


Val Pro Arg Ile Leu Asn Gly Leu Ala Ser Glu Arg Thr Ala Leu Ser 
        755                 760                 765             


Pro Gln Gln Gln Gln Gln Gln Thr Tyr Gly Ala Ile His Asn Ile Ser 
    770                 775                 780                 


Gly Thr Ile Pro Gly Gln Cys Leu Ala Gln Ser Ala Thr Gly Ser Val 
785                 790                 795                 800 


Ala Ala Ala Pro Gln Glu Ala 
                805         


<210>  49
<211>  5195
<212>  DNA
<213>  Homo sapiens

<400>  49
gaggggtcct cactcgctga ccacactgac ctcaggacca agggaacaaa acacagcagg       60

ggcaatccat ccggtccacg gagaagtgct aaaccccaaa gggtaaatga gattcccaca      120

ggaggagcag ggaggagaca acaggcaggg tggagggaac agcatgagga acagcatttg      180

agcccagcgt gtgtggcctc catgtgctga atgcgtactg gataccaagc ttgctctacg      240

gaggccctgt gaaggtggct gtggatcaca gatatcctca gctctctcca gagctcaaca      300

cagtaccaga tgctccagaa atgtttgctg aactgaattt gactggaaag gaaaacagag      360

ccccaggcct gcgcggtggc tcacgtctat aatcccagca ctgtgggagg ccgaggcaga      420

cggatcactt gaggtcagga gttcaagacc agcctggcca acatggtccc agctgcaggg      480

cagccatgag cctggtggcc tgtgagtgcc tgcccagccc cggcctggag cctgagcctt      540

gctcacgagc acggtcccaa gctcacgtgt acctggagca gattcgcaac agggtggctc      600

tgggagtgcc tgacatgaca aaacgtgact atctggtgga tgcggccacg cagatccggc      660

tggccctgga gcgcgatgtt agtgaggact atgaggcggc cttcaaccac tatcagaatg      720

gcgtggacgt gctgctccgt ggcatacacg ttgaccccaa caaggagcga cgtgaggctg      780

tgaagctgaa aattaccaaa tacctgcggc gggcagagga gatcttcaac tgccacctgc      840

agcggccgct gagcagtgga gccagcccca gcgcgggttt cagcagcctg aggctccggc      900

ccattcgcac gctgagctct gccgtggagc agctgagggg ctgcagggtg gtcggggtca      960

tcgagaaggt gcagctggtc caggacccgg caaccggagg gacctttgtg gtgaagagcc     1020

tacccaggtg ccacatggtg agcagggagc ggctgaccat catcccacac ggagtcccct     1080

acatgacgaa gctgctcagg tactttgtga gcgaggactc catcttcctg cacctggagc     1140

atgtgcaagg aggcactctc tggtcccacc tgctctccca ggcgcactcc cgacattctg     1200

ggctcagctc tggctctacc caggagagga tgaaggctca gctcaacccc cacctcaacc     1260

tcctgacccc agcgaggctt ccctcaggcc atgcccctgg ccaggacaga atcgccctgg     1320

agcctcctag gacttctccg aaccttctcc tagctgggga ggccccatcc accagacccc     1380

agagggaggc tgaaggtgaa cccacagcca ggaccagcac ctctggctcc tcggaccttc     1440

caaaggcccc aggtggccac ctgcaccttc aagctaggag ggctggccag aactcagacg     1500

ctgggccccc tcgggggctc acttgggttc ctgagggggc cggcccggtg ctagggggct     1560

gtggccgagg catggatcag agctgcctgt cagcagatgg ggccggccgg ggctgtggca     1620

gggccacctg gagtgtgaga gaggagcagg tgaagcagtg ggcggcagag atgctggtag     1680

cgctggaggc gctgcacgag cagggggtgc tgtgccggga cctccacccc gggaacctgc     1740

tcctggacca ggcaggtcac atccggctca catattttgg ccagtggtca gaggtggagc     1800

cccagtgctg cggggaggcc gtggacaatc tctacagcgc cccagaggtg ggtgggattt     1860

ccgagctgac ggaagcctgt gactggtgga gctttgggtc tctactgtat gaactgctga     1920

cgggaatggc actgtcccag agccaccctt caggaatcca ggcccacacc cagctccagc     1980

tgcccgagtg gctcagtcgc ccagcggcct ctctgctgac tgagctgctg cagttcgagc     2040

ctacccggcg cctgggcatg ggagaaggtg gtgtcagcaa actcaagtcc catccctttt     2100

tcagtaccat ccaatggagc aagctggtgg ggtaagaggg cagagcgggt gacggaagca     2160

gctggcctgg tctggatcgc ctctcctcct tgcctgacac ccaacccagg gctggccctc     2220

tatcagcggg ctttgggcga ggaatggagg gcactgtctg tcctgctggg ctcccactgg     2280

ggcctcagaa ttatggccac cacccaggaa gggccagctc ctggaaaagc tggaggtggg     2340

ggcagtcaag gcttgccctg ctaagcagct tgaaccatct acccatcagt caacagaccc     2400

gttgagcatg tggactcacc atgttaaagg ttgccttctg tggcactggc gctgagctgt     2460

tgaccacctg ctgcacccta ctgtgaggtt ctgtgactca ctcactgcca tgttgtgccc     2520

cactcaggac atctctggag actcatctca ggacactgat ccactggctc agtggaccca     2580

aaccagactg tcctggctag tcctcttagt cacacagcga gtaggcctct tccaccagaa     2640

gctgttcgtg cagctgggga ggcccagaag cagggatgcc atctgttgtg cagggaggga     2700

tgaggtaggg gacaggatga cccccacccc caccccccca cccccgattc ctgaccatgc     2760

cccctatctt gtgatttcag acttgggaga gcaaaaggga ggggaagaaa ataagagtaa     2820

tggggggagg aaggaatgca tgggtctgcc ccttagagca agtctgaaac cagaatcaag     2880

agtcctcctc cccagtgggc ctgtgtgggg gaagaggggc agcctgcccc aggggtgcaa     2940

gaggacagca attcagcttc caggccaaag cagtttagac aaggtgtgcc catcaggact     3000

ccctctcagg ccctggctgt ttaccatgtc actgcctact gtgacttcat gcccttttgg     3060

gataagaaac cacaaaacgc atggaacaac tatccatggc tcttagccag aaatgtcttg     3120

cctctggtct ctgaaaagct ggggtgagtg gttacctcaa agacaattgc ctccagtttg     3180

ggggctcctc tcagggttca ccctgtcacc ggggcgtggg accgacctgg gaaatttcca     3240

ctagagtttt gccctcagct cctccctgcc agcatcccag tcaccaccag gtggcgcttc     3300

tgacacggtc cacgtgcctg gctctgaagg cccaactgtc agaccagacc cctcactcat     3360

ggtggggaga cttgacttcc tcgggctctt caggagactg agacagagaa gacaagtgaa     3420

agcgcagcct gtacatgact ctctgtggtc cacgtcctgc ctctccctgg ggtttacacg     3480

gccccaataa agcctgctct ggcctacggt gttctcgctt cttccatgca atgaccacgg     3540

ctcattgggg caggttggaa ggctcccctg tagaagctcc agagtgaagt caagagcgag     3600

cttggggctg ccaggaagta ggacgcaggg ctggtggtga gcagcatgcc atgtgggcct     3660

caggggaagg ggtggggtcg gggaggacca ggttctgtgg ggaagaggat gaagaagcct     3720

tggaagaggc tcatggtgcc tgggggaata ccagtttcat cctcacagtg accccttgca     3780

acagacggta gctcctgaga aaactgaagc tcaaaaaggt taaggacaca acctagccag     3840

agttgcaagt tagtgttcct tctgctactc tccctaagtc aggctggacc acttccaacc     3900

accgcttcat gaagcacaag tcccttctgg aacttctgtg cttcatccac ccaaagctac     3960

acatctgaca ctttgttggg ccctgagttt agaatactgt gggtcccagc tcttacagtc     4020

gacctccttt cgataaaatg gggtaaataa tgcctatttt gcaggtttac cagatagata     4080

aattaaagct tctaacacca aatcctgttc ttcctttcat tcaacctaat ttgtttttct     4140

atctactaga gctctagttc tactctctgg gacccacttc cctcctgtga cagaccttca     4200

cagagggatg gcctcactgc aagagctcag cagacaggga ctctggaaaa gacaaggctg     4260

tgtttaagcc tggactccat cacacctgcc acctgcagtc taggttagct acccaccctg     4320

tacactcacg ctcactgacc actgctccta ggtcatcaac cctcacctgt tcatgtgtat     4380

tgaccttgag catcttggtc cacaaggcta tcaaatccaa atgaaatgag atgcccccac     4440

tcctcccaaa tccatcactg aaataatgta agcccacaca aaaaatgcaa gtctactggt     4500

gttttgaaag ggcttcacaa agatggtgac cccaaattct ctattctaga gtatggcttg     4560

acaggctcaa ggaaggtggg gcactaagag actatgatgc tttatggaaa caaaacaaaa     4620

aacatcctaa gccccccaac catctgtatg gacccctcgt ctcagtcaag ggtattccaa     4680

agttaacctg aaacgctagt tcgggccatg gtgggaagag ggagccagcc attcctcatt     4740

atactcccct cccttttgga attactgtta aaacaggctc cttaagtctg atgagaagca     4800

tttacaatct attttctctg aagcctgctg gctggaggct tcatctgcat aaaaccttgg     4860

tctccacaac cccttactgt aacccagaca ttcctttcta ttgattccag gtctttagat     4920

aataactctt tcaaccaatt gccaatcaga aaatctttga ttctgcctat gacaacatcc     4980

ccaggtcttg agctgtcctg cctctccaga ccaaaccact gtacatctta catgtactga     5040

ctggtatctt atgtctccct aaaatgtatt aaatgtataa aactaagttg tagccagacg     5100

accctggaca catgttctca ggatctccta agagttgtat cacaggccat cagtcactca     5160

cacttggctc agaataaatc tcttcaaata ttttt                                5195


<210>  50
<211>  549
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ser Leu Val Ala Cys Glu Cys Leu Pro Ser Pro Gly Leu Glu Pro 
1               5                   10                  15      


Glu Pro Cys Ser Arg Ala Arg Ser Gln Ala His Val Tyr Leu Glu Gln 
            20                  25                  30          


Ile Arg Asn Arg Val Ala Leu Gly Val Pro Asp Met Thr Lys Arg Asp 
        35                  40                  45              


Tyr Leu Val Asp Ala Ala Thr Gln Ile Arg Leu Ala Leu Glu Arg Asp 
    50                  55                  60                  


Val Ser Glu Asp Tyr Glu Ala Ala Phe Asn His Tyr Gln Asn Gly Val 
65                  70                  75                  80  


Asp Val Leu Leu Arg Gly Ile His Val Asp Pro Asn Lys Glu Arg Arg 
                85                  90                  95      


Glu Ala Val Lys Leu Lys Ile Thr Lys Tyr Leu Arg Arg Ala Glu Glu 
            100                 105                 110         


Ile Phe Asn Cys His Leu Gln Arg Pro Leu Ser Ser Gly Ala Ser Pro 
        115                 120                 125             


Ser Ala Gly Phe Ser Ser Leu Arg Leu Arg Pro Ile Arg Thr Leu Ser 
    130                 135                 140                 


Ser Ala Val Glu Gln Leu Arg Gly Cys Arg Val Val Gly Val Ile Glu 
145                 150                 155                 160 


Lys Val Gln Leu Val Gln Asp Pro Ala Thr Gly Gly Thr Phe Val Val 
                165                 170                 175     


Lys Ser Leu Pro Arg Cys His Met Val Ser Arg Glu Arg Leu Thr Ile 
            180                 185                 190         


Ile Pro His Gly Val Pro Tyr Met Thr Lys Leu Leu Arg Tyr Phe Val 
        195                 200                 205             


Ser Glu Asp Ser Ile Phe Leu His Leu Glu His Val Gln Gly Gly Thr 
    210                 215                 220                 


Leu Trp Ser His Leu Leu Ser Gln Ala His Ser Arg His Ser Gly Leu 
225                 230                 235                 240 


Ser Ser Gly Ser Thr Gln Glu Arg Met Lys Ala Gln Leu Asn Pro His 
                245                 250                 255     


Leu Asn Leu Leu Thr Pro Ala Arg Leu Pro Ser Gly His Ala Pro Gly 
            260                 265                 270         


Gln Asp Arg Ile Ala Leu Glu Pro Pro Arg Thr Ser Pro Asn Leu Leu 
        275                 280                 285             


Leu Ala Gly Glu Ala Pro Ser Thr Arg Pro Gln Arg Glu Ala Glu Gly 
    290                 295                 300                 


Glu Pro Thr Ala Arg Thr Ser Thr Ser Gly Ser Ser Asp Leu Pro Lys 
305                 310                 315                 320 


Ala Pro Gly Gly His Leu His Leu Gln Ala Arg Arg Ala Gly Gln Asn 
                325                 330                 335     


Ser Asp Ala Gly Pro Pro Arg Gly Leu Thr Trp Val Pro Glu Gly Ala 
            340                 345                 350         


Gly Pro Val Leu Gly Gly Cys Gly Arg Gly Met Asp Gln Ser Cys Leu 
        355                 360                 365             


Ser Ala Asp Gly Ala Gly Arg Gly Cys Gly Arg Ala Thr Trp Ser Val 
    370                 375                 380                 


Arg Glu Glu Gln Val Lys Gln Trp Ala Ala Glu Met Leu Val Ala Leu 
385                 390                 395                 400 


Glu Ala Leu His Glu Gln Gly Val Leu Cys Arg Asp Leu His Pro Gly 
                405                 410                 415     


Asn Leu Leu Leu Asp Gln Ala Gly His Ile Arg Leu Thr Tyr Phe Gly 
            420                 425                 430         


Gln Trp Ser Glu Val Glu Pro Gln Cys Cys Gly Glu Ala Val Asp Asn 
        435                 440                 445             


Leu Tyr Ser Ala Pro Glu Val Gly Gly Ile Ser Glu Leu Thr Glu Ala 
    450                 455                 460                 


Cys Asp Trp Trp Ser Phe Gly Ser Leu Leu Tyr Glu Leu Leu Thr Gly 
465                 470                 475                 480 


Met Ala Leu Ser Gln Ser His Pro Ser Gly Ile Gln Ala His Thr Gln 
                485                 490                 495     


Leu Gln Leu Pro Glu Trp Leu Ser Arg Pro Ala Ala Ser Leu Leu Thr 
            500                 505                 510         


Glu Leu Leu Gln Phe Glu Pro Thr Arg Arg Leu Gly Met Gly Glu Gly 
        515                 520                 525             


Gly Val Ser Lys Leu Lys Ser His Pro Phe Phe Ser Thr Ile Gln Trp 
    530                 535                 540                 


Ser Lys Leu Val Gly 
545                 


<210>  51
<211>  4735
<212>  DNA
<213>  Homo sapiens

<400>  51
gaggggcgga gccccggccc ggaggtctgt catgctgttc ccgctccagg tggccgctgt       60

aacctcttcg gtccgcgacg atcctctaga gcactgtgtg tctccccgga cgcgagcccg      120

ctcccctgaa atctgcaaaa tggctgataa tttggatgaa tttattgaag agcaaaaagc      180

cagattggcc gaagacaaag cagagttgga aagtgatcca ccttacatgg aaatgaaggg      240

aaagttgtca gcgaagcttt ctgaaaacag taagatactg atctctatgg ctaaggaaaa      300

cataccacca aatagtcaac agaccagggg ttccttagga attgattatg gattaagttt      360

accacttgga gaagactatg aacggaagaa acataaatta aaagaagaat tgcggcaaga      420

ttacagacgt tatcttactc aggaaaggtt gaaacttgaa cgtaacaaag aatacaatca      480

gtttctcagg ggtaaggaag aatccagtga aaagttcagg caggtggaaa agagtactga      540

gcccaagagt cagagaaata aaaaacctat tggtcaagtt aagcctgatc taacttcaca      600

aatacagaca tcttgtgaaa attcagaggg tcctagaaaa gatgtcttaa ctccttcaga      660

ggcatatgaa gaacttctga accaaagacg actagaggag gacagatacc gacaactaga      720

tgatgaaatc gaattaagga atagaagaat tattaaaaaa gcaaatgaag aagtgggcat      780

ttccaaccta aaacatcaaa ggtttgcaag caaggctggc attccagata gaagatttca      840

cagatttaat gaggatcgtg tttttgatag acggtatcat agaccagacc aagatcctga      900

agtaagtgaa gaaatggatg agaggtttag atatgaaagt gattttgata gaagactttc      960

gagagtgtat acaaatgaca ggatgcacag gaacaaacga gggaatatgc ctcctatgga     1020

acatgatggg gatgttatag aacagtcaaa cataagaatt tcatctgctg aaaataaaag     1080

tgctccagac aatgaaacat ccaaatctgc taatcaagat acctgtagtc cttttgcagg     1140

gatgctcttt ggaggtgaag atcgagaact tattcagaga aggaaagaga aatacagact     1200

agaactgttg gaacaaatgg ctgagcaaca gaggaacaag agacgagaaa aagatttaga     1260

actcagggtt gcagcgtctg gagcacaaga ccctgagaaa tcgcctgata gactaaagca     1320

gtttagtgtg gcaccaagac actttgaaga gatgatacca cctgaaagac ccagaatagc     1380

tttccagaca cctctccctc ctttatctgc cccatctgtc ccacccatcc catcagttca     1440

tcctgttcct tctcaaaatg aagatttgcg cagtggactc agcagcgccc ttggtgaaat     1500

ggtgtctccc aggattgcac ctctgcctcc acctccccta ctaccacctt tggctactaa     1560

ctatcgaact ccttatgatg atgcatacta tttttatggg tccaggaata ctttcgatcc     1620

cagtcttgct tattatggtt caggaatgat gggcgtacag cctgcagctt atgttagtgc     1680

tcctgtcacc caccaactag cacaacctgt tgtgaatacg gttggacaga atgaactgaa     1740

gattacaagt gatcaagtga taaattcagg attgattttt gaagataaac cgaaaccttc     1800

caaacagtca cttcagtctt accaagaggc tttgcagcag cagattcggg aaagagaaga     1860

aagaaggaag aaagaacgtg aagaaaaaga agaatatgaa gctaaattag aagctgaaat     1920

gagaacatat aatccctggg gaaaaggtgg aggtggtgct cctctcaggg atgcaaaagg     1980

aaatctgata actgatttga ataggatgca cagacaaaat atagatgcct accataaccc     2040

agatgcaaga acatatgaag ataaaagggc tgttgtatct ctagacccaa atttagccac     2100

ttcaaatgct gagaacctag aagatgctgc aaataaaagc tcaggtcata tgcaaacaca     2160

gagctctcct tttgctcggg gaaatgtatt tggtgagcct ccaactgaac ttcagattaa     2220

acagcaagaa ttatacaaga attttcttcg tttccagatt gaggaaaaga aacaaagaga     2280

ggaagcagag cgagagagac tgagaattgc agaagaaaaa gaagaaagac ggcttgcaga     2340

acagagggca cgaattcagc aggagtatga agaggaacag gaaaagaaaa gagagaaaga     2400

ggaggagcaa aggctaaaaa atgaagagca tattcggtta gctgaagaaa gacaaaaaga     2460

agcagaaaga aagaagaaag aagaagaaga aaaatataac ctgcaacttc agcactactg     2520

tgaaagagac aatttgattg gggaagaaac aaagcacatg agacagcctt ctcctatagt     2580

tcctgctctt cagaacaaaa ttgcaagcaa actccaaaga cctccttcag ttgacagcat     2640

catacgttcc tttattcatg aaagttccat gtccagggca cagtcacccc cggtacctgc     2700

caggaaaaat cagctccgtg cagaagagga gaaaaaaaat gtaattatgg aattatcaga     2760

aatgagaaaa cagcttcgta gtgaagagag gcgtctacaa gagcgattgc tacacatgga     2820

cagtgatgat gaaattccta tcaggaaaaa ggaaaggaat cccatggata tatttgatat     2880

ggctagacat cggttgcaag ctcctgtcag aagacagtcc cctaagggct tagacgctgc     2940

cacttttcag aatgttcatg attttaatga gctgaaagat agagattcag aaacacgagt     3000

tgatctgaaa tttatgtacc tggatcctcc aagagatcat cacaccttag agattcagca     3060

gcaagccctg ctaagagagc agcagaagag gctgaacaga ataaaaatgc aggaaggtgc     3120

caaagttgac ttagatgcca tcccaagtgc taaagtacga gagcaaagaa tgcccagaga     3180

tgacactagt gatttcttga aaaactcatt attggaatct gatagtgctt ttattggggc     3240

ttacggtgag acatatcctg ccattgaaga tgacgtcctc cctccaccat cacagttgcc     3300

ctctgcacgg gagcgcagga ggaacaaatg gaaaggacta gacattgata gcagtcgtcc     3360

taatgtagca ccagatggtc tctctctaaa atctatatcc agtgtaaatg ttgatgagct     3420

tagagtgaga aatgaggaac gaatgcgaag actgaatgaa tttcacaata aacctattaa     3480

tacagatgat gagagttcac tggttgaccc tgatgacatc atgaaacaca taggggatga     3540

cggatcaaac tctgtagcaa ctgagccctg gctccgccct ggcacttcag aaacgctgaa     3600

acgtttcatg gcagagcagc tgaaccagga gcagcagcag attcctggaa aaccaggcac     3660

tttcacttgg cagggcctgt cgactgcaca tggttaaaat aaacctgtac tggacccagt     3720

agtgcctttt aaggtgaaag gaatggtaaa tctgtacctt taatatgtcc tacttttggc     3780

ccctacctga aagttacttt ttttccatca tctgtatata aaattatttt tatcatgatg     3840

tatattatgt acataaataa aaggccatga ttattgattt atataataga attgtataga     3900

ttatttttgc acagttttgt cataaattag ggtggtaatg aactggattg aactactata     3960

tgtgcattat attgaattct gcttgtcatt aagataaggt gaataagtgt cttaaacgtc     4020

ctgtaaaacc ggactcccct ttgttacatg cacattttcc attgttacct cgatgcaaaa     4080

gaattcattt agtaggtaca tctattgtag ctgtgattat tccagtttct gtgtgatgca     4140

atcaaatgtc ctattaatta attattattt catgtcattt gtagctactg atacagcaga     4200

aatgaaggga actgtaatta cttgtatttt tgtaagccat acgttaaatg tttgttacat     4260

catctttctg cttctatttt tatgccaatg aaggcatttg tcttgttact aattacatga     4320

tgtaactact tcttgatata aataaatttt tattttaatt actaaaatct ttttaactac     4380

tatggagctt tctagactag ttttctagag gttgaataga ggtggggaca cccgggagtc     4440

aaggacagag agactggagt cttcttcttc caccatggaa ccttggataa gtgagtccat     4500

gtgagttttc taatcactca gtaagtgata cttctaaaaa aggaaagagt cattcaaata     4560

attgtgacat tctgactcag attagaatct cagaaccatg acagctgaga acatccccag     4620

gcactgcttc tctctctaat aatacttcct ctgatgtaat taacggttgg tagacaatat     4680

cagacaaatt tgccacaatt aaattactga tattttgaaa aaaaaaaaaa aaaaa          4735


<210>  52
<211>  1221
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Leu Phe Pro Leu Gln Val Ala Ala Val Thr Ser Ser Val Arg Asp 
1               5                   10                  15      


Asp Pro Leu Glu His Cys Val Ser Pro Arg Thr Arg Ala Arg Ser Pro 
            20                  25                  30          


Glu Ile Cys Lys Met Ala Asp Asn Leu Asp Glu Phe Ile Glu Glu Gln 
        35                  40                  45              


Lys Ala Arg Leu Ala Glu Asp Lys Ala Glu Leu Glu Ser Asp Pro Pro 
    50                  55                  60                  


Tyr Met Glu Met Lys Gly Lys Leu Ser Ala Lys Leu Ser Glu Asn Ser 
65                  70                  75                  80  


Lys Ile Leu Ile Ser Met Ala Lys Glu Asn Ile Pro Pro Asn Ser Gln 
                85                  90                  95      


Gln Thr Arg Gly Ser Leu Gly Ile Asp Tyr Gly Leu Ser Leu Pro Leu 
            100                 105                 110         


Gly Glu Asp Tyr Glu Arg Lys Lys His Lys Leu Lys Glu Glu Leu Arg 
        115                 120                 125             


Gln Asp Tyr Arg Arg Tyr Leu Thr Gln Glu Arg Leu Lys Leu Glu Arg 
    130                 135                 140                 


Asn Lys Glu Tyr Asn Gln Phe Leu Arg Gly Lys Glu Glu Ser Ser Glu 
145                 150                 155                 160 


Lys Phe Arg Gln Val Glu Lys Ser Thr Glu Pro Lys Ser Gln Arg Asn 
                165                 170                 175     


Lys Lys Pro Ile Gly Gln Val Lys Pro Asp Leu Thr Ser Gln Ile Gln 
            180                 185                 190         


Thr Ser Cys Glu Asn Ser Glu Gly Pro Arg Lys Asp Val Leu Thr Pro 
        195                 200                 205             


Ser Glu Ala Tyr Glu Glu Leu Leu Asn Gln Arg Arg Leu Glu Glu Asp 
    210                 215                 220                 


Arg Tyr Arg Gln Leu Asp Asp Glu Ile Glu Leu Arg Asn Arg Arg Ile 
225                 230                 235                 240 


Ile Lys Lys Ala Asn Glu Glu Val Gly Ile Ser Asn Leu Lys His Gln 
                245                 250                 255     


Arg Phe Ala Ser Lys Ala Gly Ile Pro Asp Arg Arg Phe His Arg Phe 
            260                 265                 270         


Asn Glu Asp Arg Val Phe Asp Arg Arg Tyr His Arg Pro Asp Gln Asp 
        275                 280                 285             


Pro Glu Val Ser Glu Glu Met Asp Glu Arg Phe Arg Tyr Glu Ser Asp 
    290                 295                 300                 


Phe Asp Arg Arg Leu Ser Arg Val Tyr Thr Asn Asp Arg Met His Arg 
305                 310                 315                 320 


Asn Lys Arg Gly Asn Met Pro Pro Met Glu His Asp Gly Asp Val Ile 
                325                 330                 335     


Glu Gln Ser Asn Ile Arg Ile Ser Ser Ala Glu Asn Lys Ser Ala Pro 
            340                 345                 350         


Asp Asn Glu Thr Ser Lys Ser Ala Asn Gln Asp Thr Cys Ser Pro Phe 
        355                 360                 365             


Ala Gly Met Leu Phe Gly Gly Glu Asp Arg Glu Leu Ile Gln Arg Arg 
    370                 375                 380                 


Lys Glu Lys Tyr Arg Leu Glu Leu Leu Glu Gln Met Ala Glu Gln Gln 
385                 390                 395                 400 


Arg Asn Lys Arg Arg Glu Lys Asp Leu Glu Leu Arg Val Ala Ala Ser 
                405                 410                 415     


Gly Ala Gln Asp Pro Glu Lys Ser Pro Asp Arg Leu Lys Gln Phe Ser 
            420                 425                 430         


Val Ala Pro Arg His Phe Glu Glu Met Ile Pro Pro Glu Arg Pro Arg 
        435                 440                 445             


Ile Ala Phe Gln Thr Pro Leu Pro Pro Leu Ser Ala Pro Ser Val Pro 
    450                 455                 460                 


Pro Ile Pro Ser Val His Pro Val Pro Ser Gln Asn Glu Asp Leu Arg 
465                 470                 475                 480 


Ser Gly Leu Ser Ser Ala Leu Gly Glu Met Val Ser Pro Arg Ile Ala 
                485                 490                 495     


Pro Leu Pro Pro Pro Pro Leu Leu Pro Pro Leu Ala Thr Asn Tyr Arg 
            500                 505                 510         


Thr Pro Tyr Asp Asp Ala Tyr Tyr Phe Tyr Gly Ser Arg Asn Thr Phe 
        515                 520                 525             


Asp Pro Ser Leu Ala Tyr Tyr Gly Ser Gly Met Met Gly Val Gln Pro 
    530                 535                 540                 


Ala Ala Tyr Val Ser Ala Pro Val Thr His Gln Leu Ala Gln Pro Val 
545                 550                 555                 560 


Val Asn Thr Val Gly Gln Asn Glu Leu Lys Ile Thr Ser Asp Gln Val 
                565                 570                 575     


Ile Asn Ser Gly Leu Ile Phe Glu Asp Lys Pro Lys Pro Ser Lys Gln 
            580                 585                 590         


Ser Leu Gln Ser Tyr Gln Glu Ala Leu Gln Gln Gln Ile Arg Glu Arg 
        595                 600                 605             


Glu Glu Arg Arg Lys Lys Glu Arg Glu Glu Lys Glu Glu Tyr Glu Ala 
    610                 615                 620                 


Lys Leu Glu Ala Glu Met Arg Thr Tyr Asn Pro Trp Gly Lys Gly Gly 
625                 630                 635                 640 


Gly Gly Ala Pro Leu Arg Asp Ala Lys Gly Asn Leu Ile Thr Asp Leu 
                645                 650                 655     


Asn Arg Met His Arg Gln Asn Ile Asp Ala Tyr His Asn Pro Asp Ala 
            660                 665                 670         


Arg Thr Tyr Glu Asp Lys Arg Ala Val Val Ser Leu Asp Pro Asn Leu 
        675                 680                 685             


Ala Thr Ser Asn Ala Glu Asn Leu Glu Asp Ala Ala Asn Lys Ser Ser 
    690                 695                 700                 


Gly His Met Gln Thr Gln Ser Ser Pro Phe Ala Arg Gly Asn Val Phe 
705                 710                 715                 720 


Gly Glu Pro Pro Thr Glu Leu Gln Ile Lys Gln Gln Glu Leu Tyr Lys 
                725                 730                 735     


Asn Phe Leu Arg Phe Gln Ile Glu Glu Lys Lys Gln Arg Glu Glu Ala 
            740                 745                 750         


Glu Arg Glu Arg Leu Arg Ile Ala Glu Glu Lys Glu Glu Arg Arg Leu 
        755                 760                 765             


Ala Glu Gln Arg Ala Arg Ile Gln Gln Glu Tyr Glu Glu Glu Gln Glu 
    770                 775                 780                 


Lys Lys Arg Glu Lys Glu Glu Glu Gln Arg Leu Lys Asn Glu Glu His 
785                 790                 795                 800 


Ile Arg Leu Ala Glu Glu Arg Gln Lys Glu Ala Glu Arg Lys Lys Lys 
                805                 810                 815     


Glu Glu Glu Glu Lys Tyr Asn Leu Gln Leu Gln His Tyr Cys Glu Arg 
            820                 825                 830         


Asp Asn Leu Ile Gly Glu Glu Thr Lys His Met Arg Gln Pro Ser Pro 
        835                 840                 845             


Ile Val Pro Ala Leu Gln Asn Lys Ile Ala Ser Lys Leu Gln Arg Pro 
    850                 855                 860                 


Pro Ser Val Asp Ser Ile Ile Arg Ser Phe Ile His Glu Ser Ser Met 
865                 870                 875                 880 


Ser Arg Ala Gln Ser Pro Pro Val Pro Ala Arg Lys Asn Gln Leu Arg 
                885                 890                 895     


Ala Glu Glu Glu Lys Lys Asn Val Ile Met Glu Leu Ser Glu Met Arg 
            900                 905                 910         


Lys Gln Leu Arg Ser Glu Glu Arg Arg Leu Gln Glu Arg Leu Leu His 
        915                 920                 925             


Met Asp Ser Asp Asp Glu Ile Pro Ile Arg Lys Lys Glu Arg Asn Pro 
    930                 935                 940                 


Met Asp Ile Phe Asp Met Ala Arg His Arg Leu Gln Ala Pro Val Arg 
945                 950                 955                 960 


Arg Gln Ser Pro Lys Gly Leu Asp Ala Ala Thr Phe Gln Asn Val His 
                965                 970                 975     


Asp Phe Asn Glu Leu Lys Asp Arg Asp Ser Glu Thr Arg Val Asp Leu 
            980                 985                 990         


Lys Phe Met Tyr Leu Asp Pro Pro  Arg Asp His His Thr  Leu Glu Ile 
        995                 1000                 1005             


Gln Gln  Gln Ala Leu Leu Arg  Glu Gln Gln Lys Arg  Leu Asn Arg 
    1010                 1015                 1020             


Ile Lys  Met Gln Glu Gly Ala  Lys Val Asp Leu Asp  Ala Ile Pro 
    1025                 1030                 1035             


Ser Ala  Lys Val Arg Glu Gln  Arg Met Pro Arg Asp  Asp Thr Ser 
    1040                 1045                 1050             


Asp Phe  Leu Lys Asn Ser Leu  Leu Glu Ser Asp Ser  Ala Phe Ile 
    1055                 1060                 1065             


Gly Ala  Tyr Gly Glu Thr Tyr  Pro Ala Ile Glu Asp  Asp Val Leu 
    1070                 1075                 1080             


Pro Pro  Pro Ser Gln Leu Pro  Ser Ala Arg Glu Arg  Arg Arg Asn 
    1085                 1090                 1095             


Lys Trp  Lys Gly Leu Asp Ile  Asp Ser Ser Arg Pro  Asn Val Ala 
    1100                 1105                 1110             


Pro Asp  Gly Leu Ser Leu Lys  Ser Ile Ser Ser Val  Asn Val Asp 
    1115                 1120                 1125             


Glu Leu  Arg Val Arg Asn Glu  Glu Arg Met Arg Arg  Leu Asn Glu 
    1130                 1135                 1140             


Phe His  Asn Lys Pro Ile Asn  Thr Asp Asp Glu Ser  Ser Leu Val 
    1145                 1150                 1155             


Asp Pro  Asp Asp Ile Met Lys  His Ile Gly Asp Asp  Gly Ser Asn 
    1160                 1165                 1170             


Ser Val  Ala Thr Glu Pro Trp  Leu Arg Pro Gly Thr  Ser Glu Thr 
    1175                 1180                 1185             


Leu Lys  Arg Phe Met Ala Glu  Gln Leu Asn Gln Glu  Gln Gln Gln 
    1190                 1195                 1200             


Ile Pro  Gly Lys Pro Gly Thr  Phe Thr Trp Gln Gly  Leu Ser Thr 
    1205                 1210                 1215             


Ala His  Gly 
    1220     


<210>  53
<211>  3137
<212>  DNA
<213>  Homo sapiens

<400>  53
aaaaccagta ttccagatca tttctctcca ttccaggaag tttgcatagc tccctggact       60

tctgctttgc actgccctgc aggagtgggt ggggaaagga agtggctttg aggcacacag      120

aggggcttgt tgaggccacc ggaggaagct tctgccacca atatgggacc tgtgcccagc      180

ctaccagaag agagcatctg aaaacatgta tcgacatggt aacccctctg cttgaagcct      240

cacatggctc cctattgcct tggtgctgaa caccctatgg ctgaccgtgg cccagcctct      300

gcaacagctc tgcctcctct ccagtggtga agacccagcc tgctgagact cctcctgcag      360

ttcctcaaca tgcctgcatt tctgctgcct cagggccttt gcgaaggttg ttccttgtaa      420

ctggaatgcc cttccatccc ttttttattc aaaaggctgc aattttaatt gaagaaagtt      480

cccttccaag gttcatgagt tgcctgactt gcccaccggt ttcctgcaag atcccttggc      540

ctggcactta gtgctcagga aatatttggt gatgggccaa ctgagtgaga aggtgggatc      600

tggtgggaag gaaagcggaa aggtagaaat tctgctcact tcctcattcc cacctcccaa      660

ggaacccctg gtgtccctgt ggaacccgct ttgggaaccg gtggttcagg tcagcctttt      720

cactttgtac tcaaagccac atcgcattga agccacaggt ggggcaaggt catgcatgac      780

ctgagtctcc aaatcccttc accctgtttg gttctgcaac ggggattagg ggagccccac      840

gatttgtttt caaaggatgt ccgggctcca ggacaggatg ccctgggtca cctgatgaca      900

ggtgtggtgg ttggaaaggg cctggtttca gctccgggta cacttcctcc ttccttctgc      960

tgcgtggtgt ggcctcttcc acgtcctcag aatccagctg ttactccgtc cgcggcctct     1020

cagctctagg gccctctgca cactggcccc cccagtgtca cgggcatcca gacgggatcc     1080

agtgcatcct cttttagaag aaaggcctgt ctccagatcc ccgagtccct ctagcatctc     1140

ccagaaggtg tcagacgcag cagtgtccag ggagcggcag cagatactct gacccatgga     1200

tcccctgggc ccggccaagc cacagtggtc gtggcgctgc tgtctgacca cgctgctgtt     1260

tcagctgctg atggctgtgt gtttcttctc ctatctgcgt gtgtctcaag acgatcccac     1320

tgtgtaccct aatgggtccc gcttcccaga cagcacaggg acccccgccc actccatccc     1380

cctgatcctg ctgtggacgt ggccttttaa caaacccata gctctgcccc gctgctcaga     1440

gatggtgcct ggcacggctg actgcaacat cactgccgac cgcaaggtgt atccacaggc     1500

agacgcggtc atcgtgcacc accgagaggt catgtacaac cccagtgccc agctcccacg     1560

ctccccgagg cggcaggggc agcgatggat ctggttcagc atggagtccc caagccactg     1620

ctggcagctg aaagccatgg acggatactt caatctcacc atgtcctacc gcagcgactc     1680

cgacatcttc acgccctacg gctggctgga gccgtggtcc ggccagcctg cccacccacc     1740

gctcaacctc tcggccaaga ccgagctggt ggcctgggca gtgtccaact gggggccaaa     1800

ctccgccagg gtgcgctact accagagcct gcaggcccat ctcaaggtgg acgtgtacgg     1860

acgctcccac aagcccctgc cccagggaac catgatggag acgctgtccc ggtacaagtt     1920

ctatctggcc ttcgagaact ccttgcaccc cgactacatc accgagaagc tgtggaggaa     1980

cgccctggag gcctgggccg tgcccgtggt gctgggcccc agcagaagca actacgagag     2040

gttcctgcca cccgacgcct tcatccacgt ggacgacttc cagagcccca aggacctggc     2100

ccggtacctg caggagctgg acaaggacca cgcccgctac ctgagctact ttcgctggcg     2160

ggagacgctg cggcctcgct ccttcagctg ggcactcgct ttctgcaagg cctgctggaa     2220

actgcaggag gaatccaggt accagacacg cggcatagcg gcttggttca cctgagaggc     2280

tggtgtgggg cctgggctgc caggaacctc attttcctgg ggcctcacct gagtgggggc     2340

ctcatctacc taaggactcg tttgcctgaa gcttcacctg cctgaggact cacctgcctg     2400

ggacggtcac ctgttgcagc ttcacctgcc tggggattca cctacctggg tcctcacttt     2460

cctggggcct cacctgctgg agtcttcggt ggccaggtat gtcccttacc tgggatttca     2520

catgctggct tccaggagcg tcccctgcgg aagcctggcc tgctggggat gtctcctggg     2580

gactttgcct actggggacc tcggctgttg gggactttac ctgctgggac ctgctcccag     2640

agaccttcca cactgaatct cacctgctag gagcctcacc tgctggggac ctcaccctgg     2700

agggcactgg gccctgggaa ctggcaccca tggggcccca cccatgagtg atggttctgg     2760

ctgatttgtt tgtgatgttg ttagccgcct gtgaggggtg cagagagata atcaccgcac     2820

cgtttccaga tgtaatactg caaagaaaac cgatgatgag gccgggtgcg gtggctcaca     2880

cctgtaatcc cagcactttg ggaggccgag gcaggcggat cacaaggtca ggagatcgag     2940

accatcctgg ccaatatggt gaaacccgtc tctactaaaa atacaaaaat ttgccgggcg     3000

tggtggtgca tgcctgtaat cccagctact tgggaagctg aggcaggaga atcgcttgaa     3060

ccagagagtc ggaggttgca gtaagccgag atcgcgccac tgcactccag cctggcgaca     3120

gagcgagact ctgtctc                                                    3137


<210>  54
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Asp Pro Leu Gly Pro Ala Lys Pro Gln Trp Ser Trp Arg Cys Cys 
1               5                   10                  15      


Leu Thr Thr Leu Leu Phe Gln Leu Leu Met Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Gln Asp Asp Pro Thr Val Tyr Pro Asn Gly Ser 
        35                  40                  45              


Arg Phe Pro Asp Ser Thr Gly Thr Pro Ala His Ser Ile Pro Leu Ile 
    50                  55                  60                  


Leu Leu Trp Thr Trp Pro Phe Asn Lys Pro Ile Ala Leu Pro Arg Cys 
65                  70                  75                  80  


Ser Glu Met Val Pro Gly Thr Ala Asp Cys Asn Ile Thr Ala Asp Arg 
                85                  90                  95      


Lys Val Tyr Pro Gln Ala Asp Ala Val Ile Val His His Arg Glu Val 
            100                 105                 110         


Met Tyr Asn Pro Ser Ala Gln Leu Pro Arg Ser Pro Arg Arg Gln Gly 
        115                 120                 125             


Gln Arg Trp Ile Trp Phe Ser Met Glu Ser Pro Ser His Cys Trp Gln 
    130                 135                 140                 


Leu Lys Ala Met Asp Gly Tyr Phe Asn Leu Thr Met Ser Tyr Arg Ser 
145                 150                 155                 160 


Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser Gly 
                165                 170                 175     


Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu Val 
            180                 185                 190         


Ala Trp Ala Val Ser Asn Trp Gly Pro Asn Ser Ala Arg Val Arg Tyr 
        195                 200                 205             


Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg Ser 
    210                 215                 220                 


His Lys Pro Leu Pro Gln Gly Thr Met Met Glu Thr Leu Ser Arg Tyr 
225                 230                 235                 240 


Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile Thr 
                245                 250                 255     


Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val Val 
            260                 265                 270         


Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp Ala 
        275                 280                 285             


Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg Tyr 
    290                 295                 300                 


Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe Arg 
305                 310                 315                 320 


Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Ala Phe 
                325                 330                 335     


Cys Lys Ala Cys Trp Lys Leu Gln Glu Glu Ser Arg Tyr Gln Thr Arg 
            340                 345                 350         


Gly Ile Ala Ala Trp Phe Thr 
        355                 


<210>  55
<211>  3919
<212>  DNA
<213>  Homo sapiens

<400>  55
gccgccgcca ccaccgctgc cactgccgcc ctgccggggc catgttcgct ctgggcttgc       60

ccttcttggt gctcttggtg gcctcggtcg agagccatct gggggttctg gggcccaaga      120

acgtctcgca gaaagacgcc gagtttgagc gcacctacgt ggacgaggtc aacagcgagc      180

tggtcaacat ctacaccttc aaccatactg tgacccgcaa caggacagag ggcgtgcgtg      240

tgtctgtgaa cgtcctgaac aagcagaagg gggcgccgtt gctgtttgtg gtccgccaga      300

aggaggctgt ggtgtccttc caggtgcccc taatcctgcg agggatgttt cagcgcaagt      360

acctctacca aaaagtggaa cgaaccctgt gtcagccccc caccaagaat gagtcggaga      420

ttcagttctt ctacgtggat gtgtccaccc tgtcaccagt caacaccaca taccagctcc      480

gggtcagccg catggacgat tttgtgctca ggactgggga gcagttcagc ttcaatacca      540

cagcagcaca gccccagtac ttcaagtatg agttccctga aggcgtggac tcggtaattg      600

tcaaggtgac ctccaacaag gccttcccct gctcagtcat ctccattcag gatgtgctgt      660

gtcctgtcta tgacctggac aacaacgtag ccttcatcgg catgtaccag acgatgacca      720

agaaggcggc catcaccgta cagcgcaaag acttccccag caacagcttt tatgtggtgg      780

tggtggtgaa gaccgaagac caagcctgcg ggggctccct gcctttctac cccttcgcag      840

aagatgaacc ggtcgatcaa gggcaccgcc agaaaaccct gtcagtgctg gtgtctcaag      900

cagtcacgtc tgaggcatac gtcagtggga tgctcttttg cctgggtata tttctctcct      960

tttacctgct gaccgtcctc ctggcctgct gggagaactg gaggcagaag aagaagaccc     1020

tgctggtggc cattgaccga gcctgcccag aaagcggtca ccctcgagtc ctggctgatt     1080

cttttcctgg cagttcccct tatgagggtt acaactatgg ctcctttgag aatgtttctg     1140

gatctaccga tggtctggtt gacagcgctg gcactgggga cctctcttac ggttaccagg     1200

gccgctcctt tgaacctgta ggtactcggc cccgagtgga ctccatgagc tctgtggagg     1260

aggatgacta cgacacattg accgacatcg attccgacaa gaatgtcatt cgcaccaagc     1320

aatacctcta tgtggctgac ctggcacgga aggacaagcg tgttctgcgg aaaaagtacc     1380

agatctactt ctggaacatt gccaccattg ctgtcttcta tgcccttcct gtggtgcagc     1440

tggtgatcac ctaccagacg gtggtgaatg tcacagggaa tcaggacatc tgctactaca     1500

acttcctctg cgcccaccca ctgggcaatc tcagcgcctt caacaacatc ctcagcaacc     1560

tggggtacat cctgctgggg ctgcttttcc tgctcatcat cctgcaacgg gagatcaacc     1620

acaaccgggc cctgctgcgc aatgacctct gtgccctgga atgtgggatc cccaaacact     1680

ttgggctttt ctacgccatg ggcacagccc tgatgatgga ggggctgctc agtgcttgct     1740

atcatgtgtg ccccaactat accaatttcc agtttgacac atcgttcatg tacatgatcg     1800

ccggactctg catgctgaag ctctaccaga agcggcaccc ggacatcaac gccagcgcct     1860

acagtgccta cgcctgcctg gccattgtca tcttcttctc tgtgctgggc gtggtctttg     1920

gcaaagggaa cacggcgttc tggatcgtct tctccatcat tcacatcatc gccaccctgc     1980

tcctcagcac gcagctctat tacatgggcc ggtggaaact ggactcgggg atcttccgcc     2040

gcatcctcca cgtgctctac acagactgca tccggcagtg cagcgggccg ctctacgtgg     2100

accgcatggt gctgctggtc atgggcaacg tcatcaactg gtcgctggct gcctatgggc     2160

ttatcatgcg ccccaatgat ttcgcttcct acttgttggc cattggcatc tgcaacctgc     2220

tcctttactt cgccttctac atcatcatga agctccggag tggggagagg atcaagctca     2280

tccccctgct ctgcatcgtt tgcacctccg tggtctgggg cttcgcgctc ttcttcttct     2340

tccagggact cagcacctgg cagaaaaccc ctgcagagtc gagggagcac aaccgggact     2400

gcatcctcct cgacttcttt gacgaccacg acatctggca cttcctctcc tccatcgcca     2460

tgttcgggtc cttcctggtg ttgctgacac tggatgacga cctggatact gtgcagcggg     2520

acaagatcta tgtcttctag caggagctgg gcccttcgct tcacctcaag gggccctgag     2580

ctcctttgtg tcatagaccg gtcactctgt cgtgctgtgg ggatgagtcc cagcaccgct     2640

gcccagcact ggatggcagc aggacagcca ggtctagctt aggcttggcc tgggacagcc     2700

atggggtggc atggaacctt gcagctgccc tctgccgagg agcaggcctg ctcccctgga     2760

acccccagat gttggccaaa ttgctgcttt cttctcagtg ttggggcctt ccatgggccc     2820

ctgtcctttg gctctccatt tgtccctttg caagaggaag gatggaaggg acaccctccc     2880

catttcatgc cttgcatttt gcccgtcctc ctccccacaa tgccccagcc tgggacctaa     2940

ggcctctttt tcctcccata ctcccactcc agggcctagt ctggggcctg aatctctgtc     3000

ctgtatcagg gccccagttc tctttgggct gtccctggct gccatcactg cccattccag     3060

tcagccagga tggatggggg tatgagattt tgggggttgg ccagctggtg ccagactttt     3120

ggtgctaagg cctgcaaggg gcctggggca gtgcgtattc tcttccctct gacctgtgct     3180

cagggctggc tctttagcaa tgcgctcagc ccaatttgag aaccgccttc tgattcaaga     3240

ggctgaattc agaggtcacc tcttcatccc atcagctccc agactgatgc cagcaccagg     3300

actggaggga gaagcgcctc accccttccc ttccttcttt ccaggccctt agtcttgcca     3360

aaccccagct ggtggccttt cagtgccatt gacactgccc aagaatgtcc aggggcaaag     3420

gagggatgat acagagttca gcccgttctg cctccacagc tgtgggcacc ccagtgccta     3480

ccttagaaag gggcttcagg aagggatgtg ctgtttccct ctacgtgccc agtcctagcc     3540

tcgctctagg acccagggct ggcttctaag tttccgtcca gtcttcaggc aagttctgtg     3600

ttagtcatgc acacacatac ctatgaaacc ttggagttta caaagaattg ccccagctct     3660

gggcaccctg gccaccctgg tccttggatc cccttcgtcc cacctggtcc accccagatg     3720

ctgaggatgg gggagctcag gcggggcctc tgctttgggg atgggaatgt gtttttctcc     3780

caaacttgtt tttatagctc tgcttgaagg gctgggagat gaggtgggtc tggatctttt     3840

ctcagagcgt ctccatgcta tggttgcatt tccgttttct atgaatgaat ttgcattcaa     3900

taaacaacca gactcagtt                                                  3919


<210>  56
<211>  832
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Phe Ala Leu Gly Leu Pro Phe Leu Val Leu Leu Val Ala Ser Val 
1               5                   10                  15      


Glu Ser His Leu Gly Val Leu Gly Pro Lys Asn Val Ser Gln Lys Asp 
            20                  25                  30          


Ala Glu Phe Glu Arg Thr Tyr Val Asp Glu Val Asn Ser Glu Leu Val 
        35                  40                  45              


Asn Ile Tyr Thr Phe Asn His Thr Val Thr Arg Asn Arg Thr Glu Gly 
    50                  55                  60                  


Val Arg Val Ser Val Asn Val Leu Asn Lys Gln Lys Gly Ala Pro Leu 
65                  70                  75                  80  


Leu Phe Val Val Arg Gln Lys Glu Ala Val Val Ser Phe Gln Val Pro 
                85                  90                  95      


Leu Ile Leu Arg Gly Met Phe Gln Arg Lys Tyr Leu Tyr Gln Lys Val 
            100                 105                 110         


Glu Arg Thr Leu Cys Gln Pro Pro Thr Lys Asn Glu Ser Glu Ile Gln 
        115                 120                 125             


Phe Phe Tyr Val Asp Val Ser Thr Leu Ser Pro Val Asn Thr Thr Tyr 
    130                 135                 140                 


Gln Leu Arg Val Ser Arg Met Asp Asp Phe Val Leu Arg Thr Gly Glu 
145                 150                 155                 160 


Gln Phe Ser Phe Asn Thr Thr Ala Ala Gln Pro Gln Tyr Phe Lys Tyr 
                165                 170                 175     


Glu Phe Pro Glu Gly Val Asp Ser Val Ile Val Lys Val Thr Ser Asn 
            180                 185                 190         


Lys Ala Phe Pro Cys Ser Val Ile Ser Ile Gln Asp Val Leu Cys Pro 
        195                 200                 205             


Val Tyr Asp Leu Asp Asn Asn Val Ala Phe Ile Gly Met Tyr Gln Thr 
    210                 215                 220                 


Met Thr Lys Lys Ala Ala Ile Thr Val Gln Arg Lys Asp Phe Pro Ser 
225                 230                 235                 240 


Asn Ser Phe Tyr Val Val Val Val Val Lys Thr Glu Asp Gln Ala Cys 
                245                 250                 255     


Gly Gly Ser Leu Pro Phe Tyr Pro Phe Ala Glu Asp Glu Pro Val Asp 
            260                 265                 270         


Gln Gly His Arg Gln Lys Thr Leu Ser Val Leu Val Ser Gln Ala Val 
        275                 280                 285             


Thr Ser Glu Ala Tyr Val Ser Gly Met Leu Phe Cys Leu Gly Ile Phe 
    290                 295                 300                 


Leu Ser Phe Tyr Leu Leu Thr Val Leu Leu Ala Cys Trp Glu Asn Trp 
305                 310                 315                 320 


Arg Gln Lys Lys Lys Thr Leu Leu Val Ala Ile Asp Arg Ala Cys Pro 
                325                 330                 335     


Glu Ser Gly His Pro Arg Val Leu Ala Asp Ser Phe Pro Gly Ser Ser 
            340                 345                 350         


Pro Tyr Glu Gly Tyr Asn Tyr Gly Ser Phe Glu Asn Val Ser Gly Ser 
        355                 360                 365             


Thr Asp Gly Leu Val Asp Ser Ala Gly Thr Gly Asp Leu Ser Tyr Gly 
    370                 375                 380                 


Tyr Gln Gly Arg Ser Phe Glu Pro Val Gly Thr Arg Pro Arg Val Asp 
385                 390                 395                 400 


Ser Met Ser Ser Val Glu Glu Asp Asp Tyr Asp Thr Leu Thr Asp Ile 
                405                 410                 415     


Asp Ser Asp Lys Asn Val Ile Arg Thr Lys Gln Tyr Leu Tyr Val Ala 
            420                 425                 430         


Asp Leu Ala Arg Lys Asp Lys Arg Val Leu Arg Lys Lys Tyr Gln Ile 
        435                 440                 445             


Tyr Phe Trp Asn Ile Ala Thr Ile Ala Val Phe Tyr Ala Leu Pro Val 
    450                 455                 460                 


Val Gln Leu Val Ile Thr Tyr Gln Thr Val Val Asn Val Thr Gly Asn 
465                 470                 475                 480 


Gln Asp Ile Cys Tyr Tyr Asn Phe Leu Cys Ala His Pro Leu Gly Asn 
                485                 490                 495     


Leu Ser Ala Phe Asn Asn Ile Leu Ser Asn Leu Gly Tyr Ile Leu Leu 
            500                 505                 510         


Gly Leu Leu Phe Leu Leu Ile Ile Leu Gln Arg Glu Ile Asn His Asn 
        515                 520                 525             


Arg Ala Leu Leu Arg Asn Asp Leu Cys Ala Leu Glu Cys Gly Ile Pro 
    530                 535                 540                 


Lys His Phe Gly Leu Phe Tyr Ala Met Gly Thr Ala Leu Met Met Glu 
545                 550                 555                 560 


Gly Leu Leu Ser Ala Cys Tyr His Val Cys Pro Asn Tyr Thr Asn Phe 
                565                 570                 575     


Gln Phe Asp Thr Ser Phe Met Tyr Met Ile Ala Gly Leu Cys Met Leu 
            580                 585                 590         


Lys Leu Tyr Gln Lys Arg His Pro Asp Ile Asn Ala Ser Ala Tyr Ser 
        595                 600                 605             


Ala Tyr Ala Cys Leu Ala Ile Val Ile Phe Phe Ser Val Leu Gly Val 
    610                 615                 620                 


Val Phe Gly Lys Gly Asn Thr Ala Phe Trp Ile Val Phe Ser Ile Ile 
625                 630                 635                 640 


His Ile Ile Ala Thr Leu Leu Leu Ser Thr Gln Leu Tyr Tyr Met Gly 
                645                 650                 655     


Arg Trp Lys Leu Asp Ser Gly Ile Phe Arg Arg Ile Leu His Val Leu 
            660                 665                 670         


Tyr Thr Asp Cys Ile Arg Gln Cys Ser Gly Pro Leu Tyr Val Asp Arg 
        675                 680                 685             


Met Val Leu Leu Val Met Gly Asn Val Ile Asn Trp Ser Leu Ala Ala 
    690                 695                 700                 


Tyr Gly Leu Ile Met Arg Pro Asn Asp Phe Ala Ser Tyr Leu Leu Ala 
705                 710                 715                 720 


Ile Gly Ile Cys Asn Leu Leu Leu Tyr Phe Ala Phe Tyr Ile Ile Met 
                725                 730                 735     


Lys Leu Arg Ser Gly Glu Arg Ile Lys Leu Ile Pro Leu Leu Cys Ile 
            740                 745                 750         


Val Cys Thr Ser Val Val Trp Gly Phe Ala Leu Phe Phe Phe Phe Gln 
        755                 760                 765             


Gly Leu Ser Thr Trp Gln Lys Thr Pro Ala Glu Ser Arg Glu His Asn 
    770                 775                 780                 


Arg Asp Cys Ile Leu Leu Asp Phe Phe Asp Asp His Asp Ile Trp His 
785                 790                 795                 800 


Phe Leu Ser Ser Ile Ala Met Phe Gly Ser Phe Leu Val Leu Leu Thr 
                805                 810                 815     


Leu Asp Asp Asp Leu Asp Thr Val Gln Arg Asp Lys Ile Tyr Val Phe 
            820                 825                 830         


<210>  57
<211>  2448
<212>  DNA
<213>  Homo sapiens

<400>  57
agaacactta caggatgtgt gtagtgtggc atgacagaga actttggttt cctttaatgt       60

gactgtagac ctggcagtgt tactataaga atcactggca atcagacacc cgggtgtgct      120

gagctagcac tcagtggggg cggctactgc tcatgtgatt gtggagtaga cagttggaag      180

aagtacccag tccatttgga gagttaaaac tgtgcctaac agaggtgtcc tctgactttt      240

cttctgcaag ctccatgttt tcacatcttc cctttgactg tgtcctgctg ctgctgctgc      300

tactacttac aaggtcctca gaagtggaat acagagcgga ggtcggtcag aatgcctatc      360

tgccctgctt ctacacccca gccgccccag ggaacctcgt gcccgtctgc tggggcaaag      420

gagcctgtcc tgtgtttgaa tgtggcaacg tggtgctcag gactgatgaa agggatgtga      480

attattggac atccagatac tggctaaatg gggatttccg caaaggagat gtgtccctga      540

ccatagagaa tgtgactcta gcagacagtg ggatctactg ctgccggatc caaatcccag      600

gcataatgaa tgatgaaaaa tttaacctga agttggtcat caaaccagcc aaggtcaccc      660

ctgcaccgac tcggcagaga gacttcactg cagcctttcc aaggatgctt accaccaggg      720

gacatggccc agcagagaca cagacactgg ggagcctccc tgatataaat ctaacacaaa      780

tatccacatt ggccaatgag ttacgggact ctagattggc caatgactta cgggactctg      840

gagcaaccat cagaataggc atctacatcg gagcagggat ctgtgctggg ctggctctgg      900

ctcttatctt cggcgcttta attttcaaat ggtattctca tagcaaagag aagatacaga      960

atttaagcct catctctttg gccaacctcc ctccctcagg attggcaaat gcagtagcag     1020

agggaattcg ctcagaagaa aacatctata ccattgaaga gaacgtatat gaagtggagg     1080

agcccaatga gtattattgc tatgtcagca gcaggcagca accctcacaa cctttgggtt     1140

gtcgctttgc aatgccatag atccaaccac cttatttttg agcttggtgt tttgtctttt     1200

tcagaaacta tgagctgtgt cacctgactg gttttggagg ttctgtccac tgctatggag     1260

cagagttttc ccattttcag aagataatga ctcacatggg aattgaactg ggacctgcac     1320

tgaacttaaa caggcatgtc attgcctctg tatttaagcc aacagagtta cccaacccag     1380

agactgttaa tcatggatgt tagagctcaa acgggctttt atatacacta ggaattcttg     1440

acgtggggtc tctggagctc caggaaattc gggcacatca tatgtccatg aaacttcaga     1500

taaactaggg aaaactgggt gctgaggtga aagcataact tttttggcac agaaagtcta     1560

aaggggccac tgattttcaa agagatctgt gatccctttt tgttttttgt ttttgagatg     1620

gagtcttgct ctgttgccca ggctggagtg caatggcaca atctcggctc actgcaagct     1680

ccgcctcctg ggttcaagcg attctcctgc ctcagcctcc tgagtggctg ggattacagg     1740

catgcaccac catgcccagc taatttgttg tatttttagt agagacaggg tttcaccatg     1800

ttggccagtg tggtctcaaa ctcctgacct catgatttgc ctgcctcggc ctcccaaagc     1860

actgggatta caggcgtgag ccaccacatc cagccagtga tccttaaaag attaagagat     1920

gactggacca ggtctacctt gatcttgaag attcccttgg aatgttgaga tttaggctta     1980

tttgagcact gcctgcccaa ctgtcagtgc cagtgcatag cccttctttt gtctccctta     2040

tgaagactgc cctgcagggc tgagatgtgg caggagctcc cagggaaaaa cgaagtgcat     2100

ttgattggtg tgtattggcc aagttttgct tgttgtgtgc ttgaaagaaa atatctctga     2160

ccaacttctg tattcgtgga ccaaactgaa gctatatttt tcacagaaga agaagcagtg     2220

acggggacac aaattctgtt gcctggtgga aagaaggcaa aggccttcag caatctatat     2280

taccagcgct ggatcctttg acagagagtg gtccctaaac ttaaatttca agacggtata     2340

ggcttgatct gtcttgctta ttgttgcccc ctgcgcctag cacaattctg acacacaatt     2400

ggaacttact aaaaattttt ttttactgtt aaaaaaaaaa aaaaaaaa                  2448


<210>  58
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly 
        195                 200                 205             


Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe 
    210                 215                 220                 


Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile 
225                 230                 235                 240 


Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu 
                245                 250                 255     


Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr 
            260                 265                 270         


Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln 
        275                 280                 285             


Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro 
    290                 295                 300     


<210>  59
<211>  2997
<212>  DNA
<213>  Homo sapiens

<400>  59
gcagctctgt aatgagatca ccatggccag cctcccaccc gagcaaaaac aaggttagcc       60

tgcagcagag ccgcagcagc aacagccacc aaagcggggg ctgaaaggga agagaactta      120

gatttgacct gtgcaaggac ctcagcagct tggacacagc ccactgcaga gatgaaagga      180

gaagctggac atatgctaca caatgaaaag tcaaagcagg agggacacat ctggggctct      240

atgaggagga cagctttcat cctgggctct ggacttctct catttgtggc cttctggaac      300

tcagtgacat ggcatcttca gagattttgg ggtgcttctg gctacttttg gcaagcccag      360

tgggagaggc tgctgactac atttgaaggg aaggagtgga tcctcttctt tataggtgcc      420

atccaagtgc cttgtctctt cttctggagc ttcaatgggc ttctattggt ggttgacaca      480

acaggaaaac ctaacttcat ctctcgctac cgaattcagg tcggcaagaa tgaacctgtg      540

gatcctgtga aactgcgcca gtctatccgc acagttcttt tcaaccagtg catgatatct      600

ttccccatgg tggtcttcct ctatcccttc ctcaaatggt ggagagaccc ctgccgccgt      660

gagctaccca ccttccactg gttcctcctg gagctggcca tcttcacgct gatcgaggaa      720

gtcttgttct actattcaca ccggctcctt caccacccaa cattctacaa gaaaatccac      780

aagaaacacc atgagtggac agctcccatt ggcgtgatct ctctctatgc ccaccctata      840

gagcatgcag tctccaacat gctaccggtg atagtgggcc cattagtaat gggctcccac      900

ttgtcctcca tcaccatgtg gttttccttg gccctcatca tcaccaccat ctcccactgt      960

ggctaccacc ttcccttcct gccttcgcct gaattccacg actaccacca tctcaagttc     1020

aaccagtgct atggggtgct gggtgtgctg gaccacctcc atgggactga caccatgttc     1080

aagcagacca aggcctacga gagacatgtc ctcctgctgg gcttcacccc gctctctgag     1140

agcatcccag actccccaaa gaggatggag tgagagacag cctaagtgtc atcctggctg     1200

tccctcagcc atgggatgca gacacggctt cctgattgca cctaacaatt tgcctccttc     1260

ggccacacgc cctaatgatg gcaccaccag ggtagaggga aggtcggctt cccggaaaag     1320

cagggccaag gatgaggctt tcttcaaact actgcccttg atgtccctca atgggatcag     1380

gagttagctt aagaaaaagg aaaacacagc tccccagact ggaggctggt cagagggagg     1440

agacccctgg tcctctgctg tggaaggaga ggggttcagc cccagataac tcctttgtgg     1500

cctgggcagg atgcagagaa tgacaaggct gaaaggaggg ggactggagg ctgcctggct     1560

ccagcgagag ctccttctgg gaccagaggg tgggacggcc aggtatcact ttgccccttc     1620

ctgccccaaa aggctttcac atacccgact caggccagag ccaagacacc ctggcaaatc     1680

attataggtc tcaattcatg acataccaga tgccagtcgc cacttcaccc aacacacaca     1740

caaacataca cacaccaaac actctgagtg agtggtaaag gccccgtttt aactctggcc     1800

caccgcaaac aaaaggtttc cctctgtggg ggagaaaaag aaatccagga gctcctccct     1860

ggattaaaac caacgaggtg cagaccaaac tttaacacct ttagccttat gtggaaacca     1920

aaaaccaact gctgggaaac tgtgaaaagc ccttttaccc acaaggggag gggtcaaagt     1980

tgctgccctt tggggacacc cgagacccct aattagccta tctgaatgag gaccaaaggt     2040

tagagccctc tttctccccg aagaaagagc ccggaaaaac atggcagagc aaagagcaaa     2100

atcctttctc ccccgaatgc tttaccagtt tctcagcaac atttattcaa gatgattttt     2160

accaggaacc ttatcaaagg caaaaccaca gctgcttggg ttgaagtccc catcctggcc     2220

tcctctcagc cgccagacat ggccaggaac cctgtggttc ccaagaacaa tttaaagatc     2280

actctttgat ttgaaagacc accattatca ttttactaaa ttcttatata tacttgtgcc     2340

ttttccaact ttcagttctc ttaagaaaaa catccactgt agctttataa aataccttag     2400

tatcagctag gtccaagtct ccaggcagga ctatcaaaat ggactccttc ttcctatcag     2460

ctctagaacc ccagaggact tgcccagtag gccagctgag cacttaccag gcagcatctc     2520

cctggccttc cacagtctcg cctgtctgtc tctggccttg gtggacctgg ctccctccct     2580

aggaggcttt tgccctcagc ttgaatacag ttcctggtgc atcaaagctg taagttctca     2640

gctgctggcc tgcactcatc acctcttcct acaaataaac atttggaaaa aagtccatct     2700

tcaatatgct taaagagaag ggtaggagat aaggagaaag aacagatacg gtttttttcc     2760

cctttaaggc ctttagattt tgaggtactg taaggggcct agaaggacaa aaggctttca     2820

ttccctcttc cttttggcag gcaggttatc agtccttggc agaagggccc agccctatcc     2880

ttttctgtat caaacaaaat ccttgaggtt ggtatacaag ttaaggctga aaaaaggcct     2940

taaattccca gtaaagaatg tgaaagcaag catgtaaaat aaactggtct tcatgaa        2997


<210>  60
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Lys Gly Glu Ala Gly His Met Leu His Asn Glu Lys Ser Lys Gln 
1               5                   10                  15      


Glu Gly His Ile Trp Gly Ser Met Arg Arg Thr Ala Phe Ile Leu Gly 
            20                  25                  30          


Ser Gly Leu Leu Ser Phe Val Ala Phe Trp Asn Ser Val Thr Trp His 
        35                  40                  45              


Leu Gln Arg Phe Trp Gly Ala Ser Gly Tyr Phe Trp Gln Ala Gln Trp 
    50                  55                  60                  


Glu Arg Leu Leu Thr Thr Phe Glu Gly Lys Glu Trp Ile Leu Phe Phe 
65                  70                  75                  80  


Ile Gly Ala Ile Gln Val Pro Cys Leu Phe Phe Trp Ser Phe Asn Gly 
                85                  90                  95      


Leu Leu Leu Val Val Asp Thr Thr Gly Lys Pro Asn Phe Ile Ser Arg 
            100                 105                 110         


Tyr Arg Ile Gln Val Gly Lys Asn Glu Pro Val Asp Pro Val Lys Leu 
        115                 120                 125             


Arg Gln Ser Ile Arg Thr Val Leu Phe Asn Gln Cys Met Ile Ser Phe 
    130                 135                 140                 


Pro Met Val Val Phe Leu Tyr Pro Phe Leu Lys Trp Trp Arg Asp Pro 
145                 150                 155                 160 


Cys Arg Arg Glu Leu Pro Thr Phe His Trp Phe Leu Leu Glu Leu Ala 
                165                 170                 175     


Ile Phe Thr Leu Ile Glu Glu Val Leu Phe Tyr Tyr Ser His Arg Leu 
            180                 185                 190         


Leu His His Pro Thr Phe Tyr Lys Lys Ile His Lys Lys His His Glu 
        195                 200                 205             


Trp Thr Ala Pro Ile Gly Val Ile Ser Leu Tyr Ala His Pro Ile Glu 
    210                 215                 220                 


His Ala Val Ser Asn Met Leu Pro Val Ile Val Gly Pro Leu Val Met 
225                 230                 235                 240 


Gly Ser His Leu Ser Ser Ile Thr Met Trp Phe Ser Leu Ala Leu Ile 
                245                 250                 255     


Ile Thr Thr Ile Ser His Cys Gly Tyr His Leu Pro Phe Leu Pro Ser 
            260                 265                 270         


Pro Glu Phe His Asp Tyr His His Leu Lys Phe Asn Gln Cys Tyr Gly 
        275                 280                 285             


Val Leu Gly Val Leu Asp His Leu His Gly Thr Asp Thr Met Phe Lys 
    290                 295                 300                 


Gln Thr Lys Ala Tyr Glu Arg His Val Leu Leu Leu Gly Phe Thr Pro 
305                 310                 315                 320 


Leu Ser Glu Ser Ile Pro Asp Ser Pro Lys Arg Met Glu 
                325                 330             


<210>  61
<211>  3912
<212>  DNA
<213>  Homo sapiens

<400>  61
cctttagaga tcggtggtgc tgaagggcag ggatcttatt ccaccttctg aagcttctgt       60

cgaaccagtt gtaaggagaa tggagagagc agtgagagtg gagtccgggg tcctggtcgg      120

ggtggtctgt ctgctcctgg catgccctgc cacagccact gggcccgaag ttgctcagcc      180

tgaagtagac accaccctgg gtcgtgtgcg aggccggcag gtgggcgtga agggcacaga      240

ccgccttgtg aatgtctttc tgggcattcc atttgcccag ccgccactgg gccctgaccg      300

gttctcagcc ccacacccag cacagccctg ggagggtgtg cgggatgcca gcactgcgcc      360

cccaatgtgc ctacaagacg tggagagcat gaacagcagc agatttgtcc tcaacggaaa      420

acagcagatc ttctccgttt cagaggactg cctggtcctc aacgtctata gcccagctga      480

ggtccccgca gggtccggta ggccggtcat ggtatgggtc catggaggcg ctctgataac      540

tggcgctgcc acctcctacg atggatcagc tctggctgcc tatggggatg tggtcgtggt      600

tacagtccag taccgccttg gggtccttgg cttcttcagc actggagatg agcatgcacc      660

tggcaaccag ggcttcctag atgtggtagc tgctttgcgc tgggtgcaag aaaacatcgc      720

ccccttcggg ggtgacctca actgtgtcac tgtctttggt ggatctgccg gtgggagcat      780

catctctggc ctggtcctgt ccccagtggc tgcagggctg ttccacagag ccatcacaca      840

gagtggggtc atcaccaccc cagggatcat cgactctcac ccttggcccc tagctcagaa      900

aatcgcaaac accttggcct gcagctccag ctccccggct gagatggtgc agtgccttca      960

gcagaaagaa ggagaagagc tggtccttag caagaagctg aaaaatacta tctatcctct     1020

caccgttgat ggcactgtct tccccaaaag ccccaaggaa ctcctgaagg agaagccctt     1080

ccactctgtg cccttcctca tgggtgtcaa caaccatgag ttcagctggc tcatccccag     1140

gggctggggt ctcctggata caatggagca gatgagccgg gaggacatgc tggccatctc     1200

aacacccgtc ttgaccagtc tggatgtgcc ccctgagatg atgcccaccg tcatagatga     1260

atacctagga agcaactcgg acgcacaagc caaatgccag gcgttccagg aattcatggg     1320

tgacgtattc atcaatgttc ccaccgtcag tttttcaaga taccttcgag attctggaag     1380

ccctgtcttt ttctatgagt tccagcatcg acccagttct tttgcgaaga tcaaacctgc     1440

ctgggtgaag gctgatcatg gggccgaggg tgcttttgtg ttcggaggtc ccttcctcat     1500

ggacgagagc tcccgcctgg cctttccaga ggccacagag gaggagaagc agctaagcct     1560

caccatgatg gcccagtgga cccactttgc ccggacaggg gaccccaata gcaaggctct     1620

gcctccttgg ccccaattca accaggcgga acaatatctg gagatcaacc cagtgccacg     1680

ggccggacag aagttcaggg aggcctggat gcagttctgg tcagagacgc tccccagcaa     1740

gatacaacag tggcaccaga agcagaagaa caggaaggcc caggaggacc tctgaggcca     1800

ggcctgaacc ttcttggctg gggcaaacca ctcttcaagt ggtggcagag tcccagcacg     1860

gcagcccgcc tctccccctg ctgagacttt aatctccacc agcccttaaa gtgtcggccg     1920

ctctgtgact ggagttatgc tcttttgaaa tgtcacaagg ccgcctccca cctctggggc     1980

attgtacaag ttcttccctc tccctgaagt gcctttcctg ctttcttcgt ggtaggttct     2040

agcacattcc tctagcttcc tggaggactc actcccccag gaagccttcc ctgccttctc     2100

tgggctgtgc ggccccgagt ctgcgtccat tagagcacag tccacccgag gctagcaccg     2160

tgtctgtgtc tgtctccccc tcagaggagc tctctcaaaa tggggattag cctaacccca     2220

ctctgtcacc cacaccagga tcgggtggga cctggagcta gggggtgttt gctgagtgag     2280

tgagtgaaac acagaatatg ggaatggcag ctgctgaact tgaacccaga gccttcaggt     2340

gccaaagcca tactcaggcc cccaccgaca ttgtccaccc tggccagaag ggtgcatgcc     2400

aatggcagag acctgggatg ggagaagtcc tggggcgcca ggggatccag cctagagcag     2460

accttagccc ctgactaagg cctcagacta gggcgggagg ggtctcctcc tctctgctgc     2520

ccagtcctgg cccctgcaca agacaacaga atccatcagg gccatgagtg tcacccagac     2580

ctgaccctca ccaattccag ccctgaccct caggacgctg gatgccagct cccagcccca     2640

gtgccgggtc ctccctccct tcctggcttg gggagaccag tttctgggga gcttccaaga     2700

gcacccacca agacacagca ggacaggcca ggggagggca tctggaccag ggcatccgtc     2760

gggctattgt cacagagaaa agaagagacc cacccactcg ggctgcaaaa ggtgaaaagc     2820

accaagaggt tttcagatgg aagtgagagg tgacagtgtg ctggcagccc tcacagccct     2880

cgcttgctct ccctgccgcc tctgcctggg ctcccacttt ggcagcactt gaggagccct     2940

tcaacccgcc gctgcactgt aggagcccct ttctgggctg gccaaggccg gagccagctc     3000

cctcagcttg cggggaggtg cggagggaga ggggcgggca ggaaccgggg ctgcgcgcag     3060

cgcttgcggg ccagagtgag ttccgggtgg gcgtgggctc ggcggggccc cactcagagc     3120

agctggccgg ccccaggcag tgagggcctt agcacctggg ccagcagctg ctgtgctcga     3180

tttctcgctg ggccttagct gcctccccgc ggggcagggc tcgggacctg cagccctcca     3240

tgcctgaccc tccccccacc ccccgtgggc tcctgtgcgg ccggagcctc cccaaggagc     3300

gccgccccct gctccacagc gcccagtccc atcgaccacc caagggctga ggagtgcggg     3360

tgcacagcgc gggactggca ggcagctcca cctgctgccc cagtgctgga tccactgggt     3420

gaagccagct gggctcctga gtctggtggg gacttggaga acctttatgt ctagctaagg     3480

gattgtaaat acaccgatgg gcactctgta tctagctcaa ggtttgtaaa cacaccaatc     3540

agcaccctgt gtctagctca gtgtttgtga atgcaccaat ccacactctg tatctggcta     3600

ctctggtggg gacttggaga acctttgtgt ccacactctg tatctagcta atctagtggg     3660

gatgtggaga acctttgtgt ctagctcagg gatcgtaaac gcaccaatca gcaccctgtc     3720

aaaacagacc acttgactct ctgtaaaatg gaccaatcag caggatgtgg gtggggcgag     3780

acaagagaat aaaagcaggc tgcctgagcc agcagtgaca acccccctcg ggtcccctcc     3840

cacgccgtgg aagctttgtt ctttcgctct ttgcaataaa tcttgctact gcccaaaaaa     3900

aaaaaaaaaa aa                                                         3912


<210>  62
<211>  571
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Glu Arg Ala Val Arg Val Glu Ser Gly Val Leu Val Gly Val Val 
1               5                   10                  15      


Cys Leu Leu Leu Ala Cys Pro Ala Thr Ala Thr Gly Pro Glu Val Ala 
            20                  25                  30          


Gln Pro Glu Val Asp Thr Thr Leu Gly Arg Val Arg Gly Arg Gln Val 
        35                  40                  45              


Gly Val Lys Gly Thr Asp Arg Leu Val Asn Val Phe Leu Gly Ile Pro 
    50                  55                  60                  


Phe Ala Gln Pro Pro Leu Gly Pro Asp Arg Phe Ser Ala Pro His Pro 
65                  70                  75                  80  


Ala Gln Pro Trp Glu Gly Val Arg Asp Ala Ser Thr Ala Pro Pro Met 
                85                  90                  95      


Cys Leu Gln Asp Val Glu Ser Met Asn Ser Ser Arg Phe Val Leu Asn 
            100                 105                 110         


Gly Lys Gln Gln Ile Phe Ser Val Ser Glu Asp Cys Leu Val Leu Asn 
        115                 120                 125             


Val Tyr Ser Pro Ala Glu Val Pro Ala Gly Ser Gly Arg Pro Val Met 
    130                 135                 140                 


Val Trp Val His Gly Gly Ala Leu Ile Thr Gly Ala Ala Thr Ser Tyr 
145                 150                 155                 160 


Asp Gly Ser Ala Leu Ala Ala Tyr Gly Asp Val Val Val Val Thr Val 
                165                 170                 175     


Gln Tyr Arg Leu Gly Val Leu Gly Phe Phe Ser Thr Gly Asp Glu His 
            180                 185                 190         


Ala Pro Gly Asn Gln Gly Phe Leu Asp Val Val Ala Ala Leu Arg Trp 
        195                 200                 205             


Val Gln Glu Asn Ile Ala Pro Phe Gly Gly Asp Leu Asn Cys Val Thr 
    210                 215                 220                 


Val Phe Gly Gly Ser Ala Gly Gly Ser Ile Ile Ser Gly Leu Val Leu 
225                 230                 235                 240 


Ser Pro Val Ala Ala Gly Leu Phe His Arg Ala Ile Thr Gln Ser Gly 
                245                 250                 255     


Val Ile Thr Thr Pro Gly Ile Ile Asp Ser His Pro Trp Pro Leu Ala 
            260                 265                 270         


Gln Lys Ile Ala Asn Thr Leu Ala Cys Ser Ser Ser Ser Pro Ala Glu 
        275                 280                 285             


Met Val Gln Cys Leu Gln Gln Lys Glu Gly Glu Glu Leu Val Leu Ser 
    290                 295                 300                 


Lys Lys Leu Lys Asn Thr Ile Tyr Pro Leu Thr Val Asp Gly Thr Val 
305                 310                 315                 320 


Phe Pro Lys Ser Pro Lys Glu Leu Leu Lys Glu Lys Pro Phe His Ser 
                325                 330                 335     


Val Pro Phe Leu Met Gly Val Asn Asn His Glu Phe Ser Trp Leu Ile 
            340                 345                 350         


Pro Arg Gly Trp Gly Leu Leu Asp Thr Met Glu Gln Met Ser Arg Glu 
        355                 360                 365             


Asp Met Leu Ala Ile Ser Thr Pro Val Leu Thr Ser Leu Asp Val Pro 
    370                 375                 380                 


Pro Glu Met Met Pro Thr Val Ile Asp Glu Tyr Leu Gly Ser Asn Ser 
385                 390                 395                 400 


Asp Ala Gln Ala Lys Cys Gln Ala Phe Gln Glu Phe Met Gly Asp Val 
                405                 410                 415     


Phe Ile Asn Val Pro Thr Val Ser Phe Ser Arg Tyr Leu Arg Asp Ser 
            420                 425                 430         


Gly Ser Pro Val Phe Phe Tyr Glu Phe Gln His Arg Pro Ser Ser Phe 
        435                 440                 445             


Ala Lys Ile Lys Pro Ala Trp Val Lys Ala Asp His Gly Ala Glu Gly 
    450                 455                 460                 


Ala Phe Val Phe Gly Gly Pro Phe Leu Met Asp Glu Ser Ser Arg Leu 
465                 470                 475                 480 


Ala Phe Pro Glu Ala Thr Glu Glu Glu Lys Gln Leu Ser Leu Thr Met 
                485                 490                 495     


Met Ala Gln Trp Thr His Phe Ala Arg Thr Gly Asp Pro Asn Ser Lys 
            500                 505                 510         


Ala Leu Pro Pro Trp Pro Gln Phe Asn Gln Ala Glu Gln Tyr Leu Glu 
        515                 520                 525             


Ile Asn Pro Val Pro Arg Ala Gly Gln Lys Phe Arg Glu Ala Trp Met 
    530                 535                 540                 


Gln Phe Trp Ser Glu Thr Leu Pro Ser Lys Ile Gln Gln Trp His Gln 
545                 550                 555                 560 


Lys Gln Lys Asn Arg Lys Ala Gln Glu Asp Leu 
                565                 570     


<210>  63
<211>  2779
<212>  DNA
<213>  Homo sapiens

<400>  63
ccggggaccg tttgtagtta ggatccgctg tggcgtcctg agtggagttt gggaccccag       60

ggagggaggg tgtgggcgtt cgggtccaga ggagctgttt agtatccaag atgaatgaca      120

gcctgtttgt cagtttggac agacttttgc tagaatttgt cttccagtat gagcaagaca      180

taagtactaa agaagagatg attcaaagaa ttaataaatg ctgtgaagat attaaggaaa      240

acaaagtaac tatttgtagg atacacgaaa ctataaatgc aacagatgag gaaattgatc      300

attactgtaa acatagtgag gagattaaag acaactgtag aaactggaag ccaacatgtg      360

atgtttttcg taaacatgaa gattatatgc aggaccaatt tactgtttat caaggaactg      420

ttgaaaaaga caaagaaatg tatcatgatt atatatgtca gtataaagaa gttttgaagc      480

agtaccaact aaaatactca gaaacaccct tttcacgtga atattatgag aagaaaagag      540

aacatgaaga aattcaaagc agagtgttgg catgtactga acaattaaaa atgaatgaaa      600

caatttttat gaaatttcga gtgcctgctc cctttccatc acttactaaa tggactttaa      660

acattgttaa tttgagatgt gaaacacaag atattcttaa acatgccagc aatcttacca      720

aaagttcatc cgaattgaag aaagaagtag atgaaatgga aatagaaatt aattatttaa      780

accagcagat atctaggcat aatgaaacta aggctctttc agaaactctg gaagaaaaga      840

acaaaaatac agaaaacaga aaagaactga aagaaagaat ttttggaaaa gatgagcatg      900

tacttacatt gaataaaact caaagcagtc aattatttct tccttatgaa tctcagaaat      960

tagtaagacc aataaagatg cattcttcag aaccaagagt tgcagatata aaagaagaaa     1020

gttctgcgaa gcagtcaaag cttgccaata ttgactttag acaaaaagaa aatgatacac     1080

agatatttaa tgactctgct gtggataacc attcaaaatg ttcacatatt acgactatca     1140

caagttcaca aaagtttatg caagtcagat tgttaacccc acagaaacaa tcaaattcca     1200

atcagtggtc ggaaaaaggg gataaagatg ctgagtatgg agataaaggg acagtaagac     1260

aagtaagaga atcaaaatgt acttcacaag ctatatatac tgaacatttt gggaagtcaa     1320

tagaaaatga tagtgatgaa gtagaagaga gagctgagaa ttttccacga acgtctgaaa     1380

ttcctatatt tttaggaact cccaaagctg tgaaagcacc tgagtcattg gagaaaataa     1440

aattccctaa aacccccccg ttcgaaatta acagaaatag aaatgcagta cctgaagttc     1500

aaacagaaaa ggaatcccct ggactttctt ttcttatgag ttatacttct agatcacctg     1560

gattgaattt atttgattct tctgtatttg atacagaaat ctcatcagat cagtttaatg     1620

aacattattc tgcaagaaat ctaaatcctc tgtcatcaga gcaagagatt ggaaacttac     1680

ttgagaagcc agaaggagaa gatggcttta cattttcttt tccatcagac acttcaactc     1740

atacatttgg agctggaaaa gatgatttta gttttccatt ttcatttgga cagggtcaaa     1800

attcaatacc ttcttcttct ttaaaaggtt tttcatcttc ctcacaaaat acaacacagt     1860

ttactttttt ttgagctagt cattaattcc ttaaattatt ttactgttct gtgttcatga     1920

gggcataaat ttacattatt gcttaaaaca tgaagactgc tttcttttat tgattaaagc     1980

agtaatgttt acattatttg attatattta ttgaaatatt gaaatactga atattttggg     2040

ttttgtgtgt gctattaact aatcattatt tattttggtt ttgattttgc gagccgtggt     2100

caggtagaac ttttattaat cttaatagaa tttgatgctt ttttcattac tctttattta     2160

aatattaagc ctgcttctcc ttggaaccta aggttttttt ctggaagtat tgttggtact     2220

ttgataagaa caagaactgc agtagtaact ccagagttag tgctgaagcg tactttagct     2280

actaaaaatt tctattaaaa ttattgggtt tcacttctgc ttcactatgt agtatacaga     2340

gtggtactgt aataataatt tcaaataatt tatgttaata acaaaatctg tgttattttc     2400

ttctaatata acacatggta caattctaat tttatgagtt atgctaatgc tttcaatggc     2460

taaaaattaa atgtaaaggg caagagtaat ttctgaaaat tggattgttg tatcagtggt     2520

gatcctgtta atattctttt ttgcttaaat attttttgaa gaacatttac aattttgtct     2580

ccttcaataa caaaaatttc ttctttatgt tttgtgttca gtatttgtca attaattata     2640

tagcttaagt gaagatattt aagatttgat gaacttctgt aaacattttg ctcaatatca     2700

ttgtattttg tgctttgtaa attagctgta ctgagttacc aagtaataaa gggtttgact     2760

ccaaaaaaaa aaaaaaaaa                                                  2779


<210>  64
<211>  587
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Asn Asp Ser Leu Phe Val Ser Leu Asp Arg Leu Leu Leu Glu Phe 
1               5                   10                  15      


Val Phe Gln Tyr Glu Gln Asp Ile Ser Thr Lys Glu Glu Met Ile Gln 
            20                  25                  30          


Arg Ile Asn Lys Cys Cys Glu Asp Ile Lys Glu Asn Lys Val Thr Ile 
        35                  40                  45              


Cys Arg Ile His Glu Thr Ile Asn Ala Thr Asp Glu Glu Ile Asp His 
    50                  55                  60                  


Tyr Cys Lys His Ser Glu Glu Ile Lys Asp Asn Cys Arg Asn Trp Lys 
65                  70                  75                  80  


Pro Thr Cys Asp Val Phe Arg Lys His Glu Asp Tyr Met Gln Asp Gln 
                85                  90                  95      


Phe Thr Val Tyr Gln Gly Thr Val Glu Lys Asp Lys Glu Met Tyr His 
            100                 105                 110         


Asp Tyr Ile Cys Gln Tyr Lys Glu Val Leu Lys Gln Tyr Gln Leu Lys 
        115                 120                 125             


Tyr Ser Glu Thr Pro Phe Ser Arg Glu Tyr Tyr Glu Lys Lys Arg Glu 
    130                 135                 140                 


His Glu Glu Ile Gln Ser Arg Val Leu Ala Cys Thr Glu Gln Leu Lys 
145                 150                 155                 160 


Met Asn Glu Thr Ile Phe Met Lys Phe Arg Val Pro Ala Pro Phe Pro 
                165                 170                 175     


Ser Leu Thr Lys Trp Thr Leu Asn Ile Val Asn Leu Arg Cys Glu Thr 
            180                 185                 190         


Gln Asp Ile Leu Lys His Ala Ser Asn Leu Thr Lys Ser Ser Ser Glu 
        195                 200                 205             


Leu Lys Lys Glu Val Asp Glu Met Glu Ile Glu Ile Asn Tyr Leu Asn 
    210                 215                 220                 


Gln Gln Ile Ser Arg His Asn Glu Thr Lys Ala Leu Ser Glu Thr Leu 
225                 230                 235                 240 


Glu Glu Lys Asn Lys Asn Thr Glu Asn Arg Lys Glu Leu Lys Glu Arg 
                245                 250                 255     


Ile Phe Gly Lys Asp Glu His Val Leu Thr Leu Asn Lys Thr Gln Ser 
            260                 265                 270         


Ser Gln Leu Phe Leu Pro Tyr Glu Ser Gln Lys Leu Val Arg Pro Ile 
        275                 280                 285             


Lys Met His Ser Ser Glu Pro Arg Val Ala Asp Ile Lys Glu Glu Ser 
    290                 295                 300                 


Ser Ala Lys Gln Ser Lys Leu Ala Asn Ile Asp Phe Arg Gln Lys Glu 
305                 310                 315                 320 


Asn Asp Thr Gln Ile Phe Asn Asp Ser Ala Val Asp Asn His Ser Lys 
                325                 330                 335     


Cys Ser His Ile Thr Thr Ile Thr Ser Ser Gln Lys Phe Met Gln Val 
            340                 345                 350         


Arg Leu Leu Thr Pro Gln Lys Gln Ser Asn Ser Asn Gln Trp Ser Glu 
        355                 360                 365             


Lys Gly Asp Lys Asp Ala Glu Tyr Gly Asp Lys Gly Thr Val Arg Gln 
    370                 375                 380                 


Val Arg Glu Ser Lys Cys Thr Ser Gln Ala Ile Tyr Thr Glu His Phe 
385                 390                 395                 400 


Gly Lys Ser Ile Glu Asn Asp Ser Asp Glu Val Glu Glu Arg Ala Glu 
                405                 410                 415     


Asn Phe Pro Arg Thr Ser Glu Ile Pro Ile Phe Leu Gly Thr Pro Lys 
            420                 425                 430         


Ala Val Lys Ala Pro Glu Ser Leu Glu Lys Ile Lys Phe Pro Lys Thr 
        435                 440                 445             


Pro Pro Phe Glu Ile Asn Arg Asn Arg Asn Ala Val Pro Glu Val Gln 
    450                 455                 460                 


Thr Glu Lys Glu Ser Pro Gly Leu Ser Phe Leu Met Ser Tyr Thr Ser 
465                 470                 475                 480 


Arg Ser Pro Gly Leu Asn Leu Phe Asp Ser Ser Val Phe Asp Thr Glu 
                485                 490                 495     


Ile Ser Ser Asp Gln Phe Asn Glu His Tyr Ser Ala Arg Asn Leu Asn 
            500                 505                 510         


Pro Leu Ser Ser Glu Gln Glu Ile Gly Asn Leu Leu Glu Lys Pro Glu 
        515                 520                 525             


Gly Glu Asp Gly Phe Thr Phe Ser Phe Pro Ser Asp Thr Ser Thr His 
    530                 535                 540                 


Thr Phe Gly Ala Gly Lys Asp Asp Phe Ser Phe Pro Phe Ser Phe Gly 
545                 550                 555                 560 


Gln Gly Gln Asn Ser Ile Pro Ser Ser Ser Leu Lys Gly Phe Ser Ser 
                565                 570                 575     


Ser Ser Gln Asn Thr Thr Gln Phe Thr Phe Phe 
            580                 585         


<210>  65
<211>  87
<212>  DNA
<213>  Homo sapiens

<400>  65
gagagagatg aagggtctta ctactgtgcc tgtgacaccc tcactggggg agacgattca       60

tccgataaac tcatctttgg aaaagga                                           87


<210>  66
<211>  5679
<212>  DNA
<213>  Homo sapiens

<400>  66
gcccgccctg gccgagcgta gctggcggac cagagccggt agcgaggttg ggagagacgg       60

agcggacctc agcgctgaag cagaagtccc cggagctgcg gtctccccgc cgcggctgag      120

ccatgcggct ccctgacctg agaccctgga cctccctgct gctggtggac gcggctttac      180

tgtggctgct tcagggccct ctggggactt tgcttcctca agggctgcca ggactatggc      240

tggaggggac cctgcggctg ggagggctgt gggggctgct aaagctaaga gggctgctgg      300

gatttgtggg gacactgctg ctcccgctct gtctggccac ccccctgact gtctccctga      360

gagccctggt cgcgggggcc tcacgtgctc ccccagccag agtcgcttca gccccttgga      420

gctggctgct ggtggggtac ggggctgcgg ggctcagctg gtcactgtgg gctgttctga      480

gccctcctgg agcccaggag aaggagcagg accaggtgaa caacaaagtc ttgatgtgga      540

ggctgctgaa gctctccagg ccggacctgc ctctcctcgt tgccgccttc ttcttccttg      600

tccttgctgt tttgggtgag acattaatcc ctcactattc tggtcgtgtg attgacatcc      660

tgggaggtga ttttgacccc catgcctttg ccagtgccat cttcttcatg tgcctcttct      720

cctttggcag ctcactgtct gcaggctgcc gaggaggctg cttcacctac accatgtctc      780

gaatcaactt gcggatccgg gagcagcttt tctcctccct gctgcgccag gacctcggtt      840

tcttccagga gactaagaca ggggagctga actcacggct gagctcggat accaccctga      900

tgagtaactg gcttccttta aatgccaatg tgctcttgcg aagcctggtg aaagtggtgg      960

ggctgtatgg cttcatgctc agcatatcgc ctcgactcac cctcctttct ctgctgcaca     1020

tgcccttcac aatagcagcg gagaaggtgt acaacacccg ccatcaggaa gtgcttcggg     1080

agatccagga tgcagtggcc agggcggggc aggtggtgcg ggaagccgtt ggagggctgc     1140

agaccgttcg cagttttggg gccgaggagc atgaagtctg tcgctataaa gaggcccttg     1200

aacaatgtcg gcagctgtat tggcggagag acctggaacg cgccttgtac ctgctcgtaa     1260

ggagggtgct gcacttgggg gtgcagatgc tgatgctgag ctgtgggctg cagcagatgc     1320

aggatgggga gctcacccag ggcagcctgc tttcctttat gatctaccag gagagcgtgg     1380

ggagctatgt gcagaccctg gtatacatat atggggatat gctcagcaac gtgggagctg     1440

cagagaaggt tttctcctac atggaccgac agccaaatct gccttcacct ggcacgcttg     1500

cccccaccac tctgcagggg gttgtgaaat tccaagacgt ctcctttgca tatcccaatc     1560

gccctgacag gcctgtgctc aaggggctga cgtttaccct acgtcctggt gaggtgacgg     1620

cgctggtggg acccaatggg tctgggaaga gcacagtggc tgccctgctg cagaatctgt     1680

accagcccac agggggacag gtgctgctgg atgaaaagcc catctcacag tatgaacact     1740

gctacctgca cagccaggtg gtttcagttg ggcaggagcc tgtgctgttc tccggttctg     1800

tgaggaacaa cattgcttat gggctgcaga gctgcgaaga tgataaggtg atggcggctg     1860

cccaggctgc ccacgcagat gacttcatcc aggaaatgga gcatggaata tacacagatg     1920

taggggagaa gggaagccag ctggctgcgg gacagaaaca acgtctggcc attgcccggg     1980

cccttgtacg agacccgcgg gtcctcatcc tggatgaggc tactagtgcc ctagatgtgc     2040

agtgcgagca ggccctgcag gactggaatt cccgtgggga tcgcacagtg ctggtgattg     2100

ctcacaggct gcaggcagtt cagcgcgccc accagatcct ggtgctccag gagggcaagc     2160

tgcagaagct tgcccagctc caggagggac aggacctcta ttcccgcctg gttcagcagc     2220

ggctgatgga ctgaggcccc agggatactg ggccctcttc tcaggggcgt ctccaggacc     2280

cagagctgtt cctgctttga gtttccctag agctgtgcgg ccagatagct gttcctgagt     2340

tgcaggcacg atggagattt ggacactgtg tgcttttggt ggggtagaga ggtggggtgg     2400

ggtggggtgg gggctgtctg tgtccaggaa acttaattcc ctggtgacta gagctttgcc     2460

tggtgatgag gagtattttg tggcataata catatatttt aaaatatttt ccttcttaca     2520

tgaactgtat acattcatat agaaaattta gacaatataa aaaagtacaa agaagaaaag     2580

taaaagtacc cattgtttca cttcctggag ataaccatag ttgctatttt gctgcctgtc     2640

ccatcagtcg tttatctgtt gtttgagata gaaattaacc aaaaatgaca taaatattca     2700

tgagattgcc ttcctatatc cttccttgtt cctaccagtg tctgctattt tgaagaagct     2760

agggtctgga gggacagaga acagttccct gattaacagt attaatagcg acattggtaa     2820

cagctaccat ttatagagtt ttaatgggag taggagctat gctaagtgtt tttcatgtat     2880

tatcgttttt aatcattatc cccaacccta tgaggttggt tattatcccc attttacaga     2940

tgaggaaact gaagctcaaa gaggctcaat gactttccca aggtggtcgt agtggtggag     3000

ttggagtttg aacacaggcc tgaccctaga gtccacaccc tgacccaatc aattatattg     3060

catcttgggt ccataaaccc taatccataa tcccatcaag aaaagctctg ctgctcttag     3120

ctctaaataa ttcagaatct attctcttct ctccagtccc gttgttatag tcttcactca     3180

tagacttaag atgatcccat caccagagag gtttctctac cattagcttc cctcttccgg     3240

ccattcttca caaagtcatt tttctaaatt ctgtgtcaca tacgatgatg gcatttctgg     3300

aaattccttc aggtgctctc aagccctgct gcagagatcc ttttcagagc acacactgtt     3360

ccagcccatc tgtctcaccc tctcctgttg tatccagctc cacgacaaac ttctgccttc     3420

cccaacacct ttgtgccttt gcatatggtg ttttcttgcc cattttctgc tcgactcgcc     3480

cctgattttc aagttcaaga cttaactcag ggttcaggtc ttccaggagg ccttacttat     3540

gtcgtcagtc tggggaactc tccatgtgct tctatcactg tgcggttacc tctttcacag     3600

cccttttaaa gttctatctt ccctttccca ccttttttga ccttccacta gaccatgagc     3660

acctgggcgg aaagccatat atcttattaa gctttatatc tgctacctgg ccgagggcct     3720

aattcatagt ggagaataaa tagtcaattg aataaatgaa taaatatctc caccatcgta     3780

ctaatcttaa tcctccctgc ccactcccac cactgaaaat gcaacattgt acacatcact     3840

ggttgttggg agggacttac cttggaaagt tgctattcta ggaaagagaa accttcatat     3900

tcctggaaac agcaggtagt ttccagtgct ggcaatgaat tccccagaac tgctgttttg     3960

gattttttct tgcctggcag ctgttgggag cagggtgcag tgaggatggg gtgagagtgg     4020

gcagtttctt gtgcagattt gcctttcttt catcctgggg ctgacttgca gctccacacc     4080

catccatctc tcaaatttca cagagggtaa aataggcatt tggagagaaa gaactctggc     4140

ctgattcctt tctctcccac aaatgtcctt tattcataaa acaggaataa taattcctgt     4200

atctcccaac tacatggaag ctgcagccct cacagaagaa gatgatctga gaaattcttt     4260

gatttcctca gtacagttat acccatgcat cataatactt taagcctgga aggcatctta     4320

aaaataatgc aacagtcaaa cctaatttta cagagaaact gacatgaaat cacgcagcta     4380

atcatgataa agctgggtgg aaaacttatc ttgatgggca gtacaggaag atgcagtaga     4440

ccttaagatg tcctgaaagt ttcttatctc aggggaaact cccaggtagg ctttatgtca     4500

gggacacaga aaaatgctcc ctgaaagtca aaatattcgg gctagacaga caaattcctg     4560

taagtgtggt ttgtctggga accacagatg tcactaatcc tggtttgctc cagagttctt     4620

tttgttcact cctacccccc atcaccattt gattgatctc cttaccctgt aatttcccct     4680

tcttgtcgct tacctgcagt atctttccca cccaggcatg ccttattctt tctaaaggaa     4740

agtatgaatg gagaggggaa agcttgggaa actgatagat ttccttggat gccaaaacac     4800

ctccatagcc tgtctgcccg gccctatgtg gaaacagcat tgagtttcaa gtcctttatg     4860

cctccaccca gggatagcca cttgtaatcc acatggcaat tgtgaaacaa gcaggaaatg     4920

cgtaattgtc agaattttgt ggggaaagga ctagggaata aggaaaacaa agatcttcct     4980

tgtgttttag agctgtcagc tagaggagca cctgcttgag tctgatgcca tctaatggtc     5040

ccagaagaaa ctgggttttg aacctagagt tccatggact cttaggaatt agactactac     5100

tactactaag cattcactgg tgcttactat gtgctattgc tgtgccaagt atctgaaacc     5160

tgtcttctta ccttattttt caagataatt ctatgtggca ggtattacta tctcaattct     5220

aagagtgaga aaatggagtt ttagaaacat ttactaactt gcctgggtca catagctaag     5280

gaagaggtgg acttgcccag ctttgcataa aactcctcaa aagagttgcc tatactccct     5340

gactccactt atcttcctac tatcctcttt ttaaaatata ttatttattt atttaaataa     5400

gcaatatatg aatgtggttt gaaattcaaa agacacaaag aagtatacag aggaaagcct     5460

cactctcaat ccttctcaag gtttgctaat tcctcttgca taggcaatcc gttcttccag     5520

ctttgtgttt atctttccag agaagtttac tgtgtattaa gcaaatatgt atatctttat     5580

tcttgctcag tattttcgca aacagcagct gtctaagttc actgttctga actttatttt     5640

ttaaattaaa aatatatggc tatgtagtat tctatttta                            5679


<210>  67
<211>  703
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Arg Leu Pro Asp Leu Arg Pro Trp Thr Ser Leu Leu Leu Val Asp 
1               5                   10                  15      


Ala Ala Leu Leu Trp Leu Leu Gln Gly Pro Leu Gly Thr Leu Leu Pro 
            20                  25                  30          


Gln Gly Leu Pro Gly Leu Trp Leu Glu Gly Thr Leu Arg Leu Gly Gly 
        35                  40                  45              


Leu Trp Gly Leu Leu Lys Leu Arg Gly Leu Leu Gly Phe Val Gly Thr 
    50                  55                  60                  


Leu Leu Leu Pro Leu Cys Leu Ala Thr Pro Leu Thr Val Ser Leu Arg 
65                  70                  75                  80  


Ala Leu Val Ala Gly Ala Ser Arg Ala Pro Pro Ala Arg Val Ala Ser 
                85                  90                  95      


Ala Pro Trp Ser Trp Leu Leu Val Gly Tyr Gly Ala Ala Gly Leu Ser 
            100                 105                 110         


Trp Ser Leu Trp Ala Val Leu Ser Pro Pro Gly Ala Gln Glu Lys Glu 
        115                 120                 125             


Gln Asp Gln Val Asn Asn Lys Val Leu Met Trp Arg Leu Leu Lys Leu 
    130                 135                 140                 


Ser Arg Pro Asp Leu Pro Leu Leu Val Ala Ala Phe Phe Phe Leu Val 
145                 150                 155                 160 


Leu Ala Val Leu Gly Glu Thr Leu Ile Pro His Tyr Ser Gly Arg Val 
                165                 170                 175     


Ile Asp Ile Leu Gly Gly Asp Phe Asp Pro His Ala Phe Ala Ser Ala 
            180                 185                 190         


Ile Phe Phe Met Cys Leu Phe Ser Phe Gly Ser Ser Leu Ser Ala Gly 
        195                 200                 205             


Cys Arg Gly Gly Cys Phe Thr Tyr Thr Met Ser Arg Ile Asn Leu Arg 
    210                 215                 220                 


Ile Arg Glu Gln Leu Phe Ser Ser Leu Leu Arg Gln Asp Leu Gly Phe 
225                 230                 235                 240 


Phe Gln Glu Thr Lys Thr Gly Glu Leu Asn Ser Arg Leu Ser Ser Asp 
                245                 250                 255     


Thr Thr Leu Met Ser Asn Trp Leu Pro Leu Asn Ala Asn Val Leu Leu 
            260                 265                 270         


Arg Ser Leu Val Lys Val Val Gly Leu Tyr Gly Phe Met Leu Ser Ile 
        275                 280                 285             


Ser Pro Arg Leu Thr Leu Leu Ser Leu Leu His Met Pro Phe Thr Ile 
    290                 295                 300                 


Ala Ala Glu Lys Val Tyr Asn Thr Arg His Gln Glu Val Leu Arg Glu 
305                 310                 315                 320 


Ile Gln Asp Ala Val Ala Arg Ala Gly Gln Val Val Arg Glu Ala Val 
                325                 330                 335     


Gly Gly Leu Gln Thr Val Arg Ser Phe Gly Ala Glu Glu His Glu Val 
            340                 345                 350         


Cys Arg Tyr Lys Glu Ala Leu Glu Gln Cys Arg Gln Leu Tyr Trp Arg 
        355                 360                 365             


Arg Asp Leu Glu Arg Ala Leu Tyr Leu Leu Val Arg Arg Val Leu His 
    370                 375                 380                 


Leu Gly Val Gln Met Leu Met Leu Ser Cys Gly Leu Gln Gln Met Gln 
385                 390                 395                 400 


Asp Gly Glu Leu Thr Gln Gly Ser Leu Leu Ser Phe Met Ile Tyr Gln 
                405                 410                 415     


Glu Ser Val Gly Ser Tyr Val Gln Thr Leu Val Tyr Ile Tyr Gly Asp 
            420                 425                 430         


Met Leu Ser Asn Val Gly Ala Ala Glu Lys Val Phe Ser Tyr Met Asp 
        435                 440                 445             


Arg Gln Pro Asn Leu Pro Ser Pro Gly Thr Leu Ala Pro Thr Thr Leu 
    450                 455                 460                 


Gln Gly Val Val Lys Phe Gln Asp Val Ser Phe Ala Tyr Pro Asn Arg 
465                 470                 475                 480 


Pro Asp Arg Pro Val Leu Lys Gly Leu Thr Phe Thr Leu Arg Pro Gly 
                485                 490                 495     


Glu Val Thr Ala Leu Val Gly Pro Asn Gly Ser Gly Lys Ser Thr Val 
            500                 505                 510         


Ala Ala Leu Leu Gln Asn Leu Tyr Gln Pro Thr Gly Gly Gln Val Leu 
        515                 520                 525             


Leu Asp Glu Lys Pro Ile Ser Gln Tyr Glu His Cys Tyr Leu His Ser 
    530                 535                 540                 


Gln Val Val Ser Val Gly Gln Glu Pro Val Leu Phe Ser Gly Ser Val 
545                 550                 555                 560 


Arg Asn Asn Ile Ala Tyr Gly Leu Gln Ser Cys Glu Asp Asp Lys Val 
                565                 570                 575     


Met Ala Ala Ala Gln Ala Ala His Ala Asp Asp Phe Ile Gln Glu Met 
            580                 585                 590         


Glu His Gly Ile Tyr Thr Asp Val Gly Glu Lys Gly Ser Gln Leu Ala 
        595                 600                 605             


Ala Gly Gln Lys Gln Arg Leu Ala Ile Ala Arg Ala Leu Val Arg Asp 
    610                 615                 620                 


Pro Arg Val Leu Ile Leu Asp Glu Ala Thr Ser Ala Leu Asp Val Gln 
625                 630                 635                 640 


Cys Glu Gln Ala Leu Gln Asp Trp Asn Ser Arg Gly Asp Arg Thr Val 
                645                 650                 655     


Leu Val Ile Ala His Arg Leu Gln Ala Val Gln Arg Ala His Gln Ile 
            660                 665                 670         


Leu Val Leu Gln Glu Gly Lys Leu Gln Lys Leu Ala Gln Leu Gln Glu 
        675                 680                 685             


Gly Gln Asp Leu Tyr Ser Arg Leu Val Gln Gln Arg Leu Met Asp 
    690                 695                 700             


