                         SEQUENCE LISTING

<110>  DANA-FARBER CANCER INSTITUTE, INC.
       BOSTON CHILDREN'S HOSPITAL
 
<120>  Agents That Modulate Immune Cell Activation And Methods Of Use 
       Thereof

<130>  DFS-112.25

<140>  PCT/US2013/053393
<141>  2013-08-02

<150>  61/742,137
<151>  2012-08-03

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  921
<212>  DNA
<213>  Homo sapiens

<400>  1
cactctggtg gggctgctcc aggcatgcag atcccacagg cgccctggcc agtcgtctgg       60

gcggtgctac aactgggctg gcggccagga tggttcttag actccccaga caggccctgg      120

aaccccccca ccttctcccc agccctgctc gtggtgaccg aaggggacaa cgccaccttc      180

acctgcagct tctccaacac atcggagagc ttcgtgctaa actggtaccg catgagcccc      240

agcaaccaga cggacaagct ggccgccttc cccgaggacc gcagccagcc cggccaggac      300

tgccgcttcc gtgtcacaca actgcccaac gggcgtgact tccacatgag cgtggtcagg      360

gcccggcgca atgacagcgg cacctacctc tgtggggcca tctccctggc ccccaaggcg      420

cagatcaaag agagcctgcg ggcagagctc agggtgacag agagaagggc agaagtgccc      480

acagcccacc ccagcccctc acccaggtca gccggccagt tccaaaccct ggtggttggt      540

gtcgtgggcg gcctgctggg cagcctggtg ctgctagtct gggtcctggc cgtcatctgc      600

tcccgggccg cacgagggac aataggagcc aggcgcaccg gccagcccct gaaggaggac      660

ccctcagccg tgcctgtgtt ctctgtggac tatggggagc tggatttcca gtggcgagag      720

aagaccccgg agccccccgt gccctgtgtc cctgagcaga cggagtatgc caccattgtc      780

tttcctagcg gaatgggcac ctcatccccc gcccgcaggg gctcagctga cggccctcgg      840

agtgcccagc cactgaggcc tgaggatgga cactgctctt ggcccctctg accggcttcc      900

ttggccacca gtgttctgca g                                                921


<210>  2
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Ser Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  3
<211>  968
<212>  DNA
<213>  Homo sapiens

<400>  3
gcttcccgag gctccgcacc agccgcgctt ctgtccgcct gcagggcatt ccagaaagat       60

gaggatattt gctgtcttta tattcatgac ctactggcat ttgctgaacg catttactgt      120

cacggttccc aaggacctat atgtggtaga gtatggtagc aatatgacaa ttgaatgcaa      180

attcccagta gaaaaacaat tagacctggc tgcactaatt gtctattggg aaatggagga      240

taagaacatt attcaatttg tgcatggaga ggaagacctg aaggttcagc atagtagcta      300

cagacagagg gcccggctgt tgaaggacca gctctccctg ggaaatgctg cacttcagat      360

cacagatgtg aaattgcagg atgcaggggt gtaccgctgc atgatcagct atggtggtgc      420

cgactacaag cgaattactg tgaaagtcaa tgccccatac aacaaaatca accaaagaat      480

tttggttgtg gatccagtca cctctgaaca tgaactgaca tgtcaggctg agggctaccc      540

caaggccgaa gtcatctgga caagcagtga ccatcaagtc ctgagtggta agaccaccac      600

caccaattcc aagagagagg agaagctttt caatgtgacc agcacactga gaatcaacac      660

aacaactaat gagattttct actgcacttt taggagatta gatcctgagg aaaaccatac      720

agctgaattg gtcatcccag gtaatattct gaatgtgtcc attaaaatat gtctaacact      780

gtcccctagc acctagcatg atgtctgcct atcatagtca ttcagtgatt gttgaataaa      840

tgaatgaatg aataacacta tgtttacaaa atatatccta attcctcacc tccattcatc      900

caaaccatat tgttacttaa taaacattca gcagatattt atggaataaa aaaaaaaaaa      960

aaaaaaaa                                                               968


<210>  4
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile Cys Leu Thr 
225                 230                 235                 240 


Leu Ser Pro Ser Thr 
                245 


<210>  5
<211>  1553
<212>  DNA
<213>  Homo sapiens

<400>  5
cgaggctccg caccagccgc gcttctgtcc gcctgcaggg cattccagaa agatgaggat       60

atttgctgtc tttatattca tgacctactg gcatttgctg aacgcattta ctgtcacggt      120

tcccaaggac ctatatgtgg tagagtatgg tagcaatatg acaattgaat gcaaattccc      180

agtagaaaaa caattagacc tggctgcact aattgtctat tgggaaatgg aggataagaa      240

cattattcaa tttgtgcatg gagaggaaga cctgaaggtt cagcatagta gctacagaca      300

gagggcccgg ctgttgaagg accagctctc cctgggaaat gctgcacttc agatcacaga      360

tgtgaaattg caggatgcag gggtgtaccg ctgcatgatc agctatggtg gtgccgacta      420

caagcgaatt actgtgaaag tcaatgcccc atacaacaaa atcaaccaaa gaattttggt      480

tgtggatcca gtcacctctg aacatgaact gacatgtcag gctgagggct accccaaggc      540

cgaagtcatc tggacaagca gtgaccatca agtcctgagt ggtaagacca ccaccaccaa      600

ttccaagaga gaggagaagc ttttcaatgt gaccagcaca ctgagaatca acacaacaac      660

taatgagatt ttctactgca cttttaggag attagatcct gaggaaaacc atacagctga      720

attggtcatc ccagaactac ctctggcaca tcctccaaat gaaaggactc acttggtaat      780

tctgggagcc atcttattat gccttggtgt agcactgaca ttcatcttcc gtttaagaaa      840

agggagaatg atggatgtga aaaaatgtgg catccaagat acaaactcaa agaagcaaag      900

tgatacacat ttggaggaga cgtaatccag cattggaact tctgatcttc aagcagggat      960

tctcaacctg tggtttaggg gttcatcggg gctgagcgtg acaagaggaa ggaatgggcc     1020

cgtgggatgc aggcaatgtg ggacttaaaa ggcccaagca ctgaaaatgg aacctggcga     1080

aagcagagga ggagaatgaa gaaagatgga gtcaaacagg gagcctggag ggagaccttg     1140

atactttcaa atgcctgagg ggctcatcga cgcctgtgac agggagaaag gatacttctg     1200

aacaaggagc ctccaagcaa atcatccatt gctcatccta ggaagacggg ttgagaatcc     1260

ctaatttgag ggtcagttcc tgcagaagtg ccctttgcct ccactcaatg cctcaatttg     1320

ttttctgcat gactgagagt ctcagtgttg gaacgggaca gtatttatgt atgagttttt     1380

cctatttatt ttgagtctgt gaggtcttct tgtcatgtga gtgtggttgt gaatgatttc     1440

ttttgaagat atattgtagt agatgttaca attttgtcgc caaactaaac ttgctgctta     1500

atgatttgct cacatctagt aaaacatgga gtatttgtaa aaaaaaaaaa aaa            1553


<210>  6
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  7
<211>  819
<212>  DNA
<213>  Homo sapiens

<400>  7
atgatcttcc tcctgctaat gttgagcctg gaattgcagc ttcaccagat agcagcttta       60

ttcacagtga cagtccctaa ggaactgtac ataatagagc atggcagcaa tgtgaccctg      120

gaatgcaact ttgacactgg aagtcatgtg aaccttggag caataacagc cagtttgcaa      180

aaggtggaaa atgatacatc cccacaccgt gaaagagcca ctttgctgga ggagcagctg      240

cccctaggga aggcctcgtt ccacatacct caagtccaag tgagggacga aggacagtac      300

caatgcataa tcatctatgg ggtcgcctgg gactacaagt acctgactct gaaagtcaaa      360

gcttcctaca ggaaaataaa cactcacatc ctaaaggttc cagaaacaga tgaggtagag      420

ctcacctgcc aggctacagg ttatcctctg gcagaagtat cctggccaaa cgtcagcgtt      480

cctgccaaca ccagccactc caggacccct gaaggcctct accaggtcac cagtgttctg      540

cgcctaaagc caccccctgg cagaaacttc agctgtgtgt tctggaatac tcacgtgagg      600

gaacttactt tggccagcat tgaccttcaa agtcagatgg aacccaggac ccatccaact      660

tggctgcttc acattttcat cccctcctgc atcattgctt tcattttcat agccacagtg      720

atagccctaa gaaaacaact ctgtcaaaag ctgtattctt caaaagacac aacaaaaaga      780

cctgtcacca caacaaagag ggaagtgaac agtgctatc                             819


<210>  8
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His 
    210                 215                 220                 


Ile Phe Ile Pro Ser Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val 
225                 230                 235                 240 


Ile Ala Leu Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp 
                245                 250                 255     


Thr Thr Lys Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala 
            260                 265                 270         


Ile 
    


<210>  9
<211>  1437
<212>  DNA
<213>  Homo sapiens

<400>  9
atgataagga agaagaggaa gcgaagcgcg ccccccggcc catgccgcag ccacgggccc       60

agacccgcca cggcgcccgc gccgccgccc tcgccggagc ccacgagacc tgcatggacg      120

ggcatgggct tgagagcagc accttccagc gccgccgctg ccgccgccga ggttgagcag      180

cgccgcagcc ccgggctctg ccccccgccg ctggagctgc tgctgctgct gctgttcagc      240

ctcgggctgc tccacgcagg tgactgccaa cagccagccc aatgtcgaat ccagaaatgc      300

accacggact tcgtgtccct gacttctcac ctgaactctg ccgttgacgg ctttgactct      360

gagttttgca aggccttgcg tgcctatgct ggctgcaccc agcgaacttc aaaagcctgc      420

cgtggcaacc tggtatacca ttctgccgtg ttgggtatca gtgacctcat gagccagagg      480

aattgttcca aggatggacc cacatcctct accaaccccg aagtgaccca tgatccttgc      540

aactatcaca gccacgctgg agccagggaa cacaggagag gggaccagaa ccctcccagt      600

tacctttttt gtggcttgtt tggagatcct cacctcagaa ctttcaagga taacttccaa      660

acatgcaaag tagaaggggc ctggccactc atagataata attatctttc agttcaagtg      720

acaaacgtac ctgtggtccc tggatccagt gctactgcta caaataagat cactattatc      780

ttcaaagccc accatgagtg tacagatcag aaagtctacc aagctgtgac agatgacctg      840

ccggccgcct ttgtggatgg caccaccagt ggtggggaca gcgatgccaa gagcctgcgt      900

atcgtggaaa gggagagtgg ccactatgtg gagatgcacg cccgctatat agggaccaca      960

gtgtttgtgc ggcaggtggg tcgctacctg acccttgcca tccgtatgcc tgaagacctg     1020

gccatgtcct acgaggagag ccaggacctg cagctgtgcg tgaacggctg ccccctgagt     1080

gaacgcatcg atgacgggca gggccaggtg tctgccatcc tgggacacag cctgcctcgc     1140

acctccttgg tgcaggcctg gcctggctac acactggaga ctgccaacac tcaatgccat     1200

gagaagatgc cagtgaagga catctatttc cagtcctgtg tcttcgacct gctcaccact     1260

ggtgatgcca actttactgc cgcagcccac agtgccttgg aggatgtgga ggccctgcac     1320

ccaaggaagg aacgctggca cattttcccc agcagtggca atgggactcc ccgtggaggc     1380

agtgatttgt ctgtcagtct aggactcacc tgcttgatcc ttatcgtgtt tttgtag        1437


<210>  10
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ile Arg Lys Lys Arg Lys Arg Ser Ala Pro Pro Gly Pro Cys Arg 
1               5                   10                  15      


Ser His Gly Pro Arg Pro Ala Thr Ala Pro Ala Pro Pro Pro Ser Pro 
            20                  25                  30          


Glu Pro Thr Arg Pro Ala Trp Thr Gly Met Gly Leu Arg Ala Ala Pro 
        35                  40                  45              


Ser Ser Ala Ala Ala Ala Ala Ala Glu Val Glu Gln Arg Arg Ser Pro 
    50                  55                  60                  


Gly Leu Cys Pro Pro Pro Leu Glu Leu Leu Leu Leu Leu Leu Phe Ser 
65                  70                  75                  80  


Leu Gly Leu Leu His Ala Gly Asp Cys Gln Gln Pro Ala Gln Cys Arg 
                85                  90                  95      


Ile Gln Lys Cys Thr Thr Asp Phe Val Ser Leu Thr Ser His Leu Asn 
            100                 105                 110         


Ser Ala Val Asp Gly Phe Asp Ser Glu Phe Cys Lys Ala Leu Arg Ala 
        115                 120                 125             


Tyr Ala Gly Cys Thr Gln Arg Thr Ser Lys Ala Cys Arg Gly Asn Leu 
    130                 135                 140                 


Val Tyr His Ser Ala Val Leu Gly Ile Ser Asp Leu Met Ser Gln Arg 
145                 150                 155                 160 


Asn Cys Ser Lys Asp Gly Pro Thr Ser Ser Thr Asn Pro Glu Val Thr 
                165                 170                 175     


His Asp Pro Cys Asn Tyr His Ser His Ala Gly Ala Arg Glu His Arg 
            180                 185                 190         


Arg Gly Asp Gln Asn Pro Pro Ser Tyr Leu Phe Cys Gly Leu Phe Gly 
        195                 200                 205             


Asp Pro His Leu Arg Thr Phe Lys Asp Asn Phe Gln Thr Cys Lys Val 
    210                 215                 220                 


Glu Gly Ala Trp Pro Leu Ile Asp Asn Asn Tyr Leu Ser Val Gln Val 
225                 230                 235                 240 


Thr Asn Val Pro Val Val Pro Gly Ser Ser Ala Thr Ala Thr Asn Lys 
                245                 250                 255     


Ile Thr Ile Ile Phe Lys Ala His His Glu Cys Thr Asp Gln Lys Val 
            260                 265                 270         


Tyr Gln Ala Val Thr Asp Asp Leu Pro Ala Ala Phe Val Asp Gly Thr 
        275                 280                 285             


Thr Ser Gly Gly Asp Ser Asp Ala Lys Ser Leu Arg Ile Val Glu Arg 
    290                 295                 300                 


Glu Ser Gly His Tyr Val Glu Met His Ala Arg Tyr Ile Gly Thr Thr 
305                 310                 315                 320 


Val Phe Val Arg Gln Val Gly Arg Tyr Leu Thr Leu Ala Ile Arg Met 
                325                 330                 335     


Pro Glu Asp Leu Ala Met Ser Tyr Glu Glu Ser Gln Asp Leu Gln Leu 
            340                 345                 350         


Cys Val Asn Gly Cys Pro Leu Ser Glu Arg Ile Asp Asp Gly Gln Gly 
        355                 360                 365             


Gln Val Ser Ala Ile Leu Gly His Ser Leu Pro Arg Thr Ser Leu Val 
    370                 375                 380                 


Gln Ala Trp Pro Gly Tyr Thr Leu Glu Thr Ala Asn Thr Gln Cys His 
385                 390                 395                 400 


Glu Lys Met Pro Val Lys Asp Ile Tyr Phe Gln Ser Cys Val Phe Asp 
                405                 410                 415     


Leu Leu Thr Thr Gly Asp Ala Asn Phe Thr Ala Ala Ala His Ser Ala 
            420                 425                 430         


Leu Glu Asp Val Glu Ala Leu His Pro Arg Lys Glu Arg Trp His Ile 
        435                 440                 445             


Phe Pro Ser Ser Gly Asn Gly Thr Pro Arg Gly Gly Ser Asp Leu Ser 
    450                 455                 460                 


Val Ser Leu Gly Leu Thr Cys Leu Ile Leu Ile Val Phe Leu 
465                 470                 475             


<210>  11
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody 9D1 vK DNA

<400>  11
atgatggctg cagttcagct cttagggctt ttgctgctct gcctccgagc catgagatgt       60

gacatccaga tgacccagtc tccttcacac ctgtcagcat ctgtgggaga cagagtcact      120

ctcagctgca aagtaagtca gaatatttac aagtacttaa actggtatca gcaaaaactt      180

ggagaagctc ccaaactcct gatatattat acaagctttt tgcaaacggg catcccgtca      240

aggttcagtg gcagtggatc tggtacagat tacacactca ccatcagcag cctgcagcct      300

gaagatgttg ccacatattt ctgccagaag tattatagcg ggtggacgtt cggtggaggc      360

accaagctgg aattgaaa                                                    378


<210>  12
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 9D1 vK Protein

<400>  12

Met Met Ala Ala Val Gln Leu Leu Gly Leu Leu Leu Leu Cys Leu Arg 
1               5                   10                  15      


Ala Met Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser His Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Leu Ser Cys Lys Val Ser Gln Asn 
        35                  40                  45              


Ile Tyr Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Phe Leu Gln Thr Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Phe Cys Gln Lys Tyr Tyr 
            100                 105                 110         


Ser Gly Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125     


<210>  13
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody 9D1 vH DNA

<400>  13
atgggatgga gccagatcat tctctttctg gtggcagcaa ctacatgtgt ccactcccag       60

gtacagctac agcaatcagg gactgaactg gtgaagcctg ggtcctcagt gaaaatttcc      120

tgcaaggctt ctggcgacac cttcaccagt gactatatgc actggataag gcagcagcct      180

ggaagtggcc ttgagtggat tgggtggatt tatcctggaa atggtaatac taagtacaat      240

caaaagttcg atgggaaggc aacactcact gcagacaaat cctccagcac agcctatttg      300

cagctcagcc tcctgacatc tgaggactat gcagtctatt tctgtgcaag acagacggag      360

gggtactttg attactgggg ccaaggagtc atggtcacag tctcctca                   408


<210>  14
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 9D1 vH Protein

<400>  14

Met Gly Trp Ser Gln Ile Ile Leu Phe Leu Val Ala Ala Thr Thr Cys 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Asp Thr Phe 
        35                  40                  45              


Thr Ser Asp Tyr Met His Trp Ile Arg Gln Gln Pro Gly Ser Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asn Gly Asn Thr Lys Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Asp Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Leu Ser Leu Leu Thr Ser Glu Asp Tyr Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gln Thr Glu Gly Tyr Phe Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Val Met Val Thr Val Ser Ser 
    130                 135     


