                         SEQUENCE LISTING

<110>  biOasis Technologies, Inc. 
 
<120>  DEPHOSPHORYLATED LYSOSOMAL STORAGE DISEASE PROTEINS AND METHODS 
       OF USE THEREOF

<130>  BIOA-006/01WO

<150>  US 61/677,959
<151>  2012-07-31

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Gly Pro Ser Gly Ala Leu Trp Leu Leu Leu Ala Leu Arg Thr 
1               5                   10                  15      


Val Leu Gly Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu 
            20                  25                  30          


Gln His Lys Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile 
        35                  40                  45              


Gln Pro Ser Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val 
    50                  55                  60                  


Gln Leu Ile Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly 
65                  70                  75                  80  


Ala Ile Tyr Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly 
                85                  90                  95      


Glu Val Tyr Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val 
            100                 105                 110         


Val Arg Arg Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys 
        115                 120                 125             


Ser Cys His Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val 
    130                 135                 140                 


Gly Tyr Leu Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val 
145                 150                 155                 160 


Leu Lys Ala Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala 
                165                 170                 175     


Gly Glu Thr Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp 
            180                 185                 190         


Ser Ser Gly Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr 
        195                 200                 205             


Asp Tyr Ser Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val 
    210                 215                 220                 


Ala Phe Val Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr 
225                 230                 235                 240 


Leu Pro Ser Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu 
                245                 250                 255     


Cys Arg Asp Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His 
            260                 265                 270         


Leu Ala Arg Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp 
        275                 280                 285             


Gly Gly Leu Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser 
    290                 295                 300                 


His Glu Gly Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln 
305                 310                 315                 320 


Lys Asp Leu Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala 
                325                 330                 335     


Thr Gln Thr Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met 
            340                 345                 350         


Lys Gly Leu Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp 
        355                 360                 365             


Cys Val Leu Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val 
    370                 375                 380                 


Ala Phe Arg Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala 
385                 390                 395                 400 


Lys Ser Pro Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp 
                405                 410                 415     


Ala Val Thr Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr 
            420                 425                 430         


Gly Leu Val Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser 
        435                 440                 445             


Asn Ser Tyr Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala 
    450                 455                 460                 


Phe Thr Leu Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe 
465                 470                 475                 480 


Gly Ser Pro Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg 
                485                 490                 495     


Gly Phe Ile Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu 
            500                 505                 510         


Phe Phe Asn Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro 
        515                 520                 525             


Ser Ser Leu Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys 
    530                 535                 540                 


Cys Val Gly Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe 
545                 550                 555                 560 


Arg Cys Leu Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr 
                565                 570                 575     


Thr Val Phe Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala 
            580                 585                 590         


Glu Leu Arg Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg 
        595                 600                 605             


Ala Glu Val Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile Pro Pro 
    610                 615                 620                 


His Ala Val Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly 
625                 630                 635                 640 


Leu Leu Asp Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn 
                645                 650                 655     


Gly Phe Lys Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp Leu Leu 
            660                 665                 670         


Phe Lys Asp Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys Thr Thr 
        675                 680                 685             


Tyr Arg Gly Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu Gly Met 
    690                 695                 700                 


Ser Ser Gln Gln Cys Ser Gly Ala Ala Ala Pro Ala Pro Gly Ala Pro 
705                 710                 715                 720 


Leu Leu Pro Leu Leu Leu Pro Ala Leu Ala Ala Arg Leu Leu Pro Pro 
                725                 730                 735     


Ala Leu 
        


<210>  2
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala Leu Asn Val Leu Leu 
1               5                   10                  15      


Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly Cys Tyr Gly Asp Lys 
            20                  25                  30          


Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser Leu Leu 
        35                  40                  45              


Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser Arg Val 
    50                  55                  60                  


Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr Asp Phe 
65                  70                  75                  80  


Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile Pro Gln 
                85                  90                  95      


Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys Val Phe 
            100                 105                 110         


His Pro Gly Ile Ser Ser Asn His Thr Asp Asp Ser Pro Tyr Ser Trp 
        115                 120                 125             


Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys Tyr Glu Asn Thr Lys 
    130                 135                 140                 


Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala Asn Leu Leu Cys Pro 
145                 150                 155                 160 


Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu Pro Asp Lys Gln Ser 
                165                 170                 175     


Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met Lys Thr Ser Ala Ser 
            180                 185                 190         


Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro His Ile Pro Phe Arg 
        195                 200                 205             


Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu Glu Asn Ile Thr Leu 
    210                 215                 220                 


Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro Pro Val Ala Tyr Asn 
225                 230                 235                 240 


Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val Gln Ala Leu Asn Ile 
                245                 250                 255     


Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe Gln Arg Lys Ile Arg 
            260                 265                 270         


Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp Thr Gln Val Gly Arg 
        275                 280                 285             


Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala Asn Ser Thr Ile Ile 
    290                 295                 300                 


Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly Glu His Gly Glu Trp 
305                 310                 315                 320 


Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His Val Pro Leu Ile Phe 
                325                 330                 335     


Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu Ala Gly Glu Lys Leu 
            340                 345                 350         


Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser Gln Leu Met Glu Pro 
        355                 360                 365             


Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val Ser Leu Phe Pro Thr 
    370                 375                 380                 


Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro Arg Cys Pro Val Pro 
385                 390                 395                 400 


Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys Asn Leu Leu Lys His 
                405                 410                 415     


Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr Leu Pro Gly Asn Pro 
            420                 425                 430         


Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg Pro Ser Asp Ile Pro 
        435                 440                 445             


Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp Ile Lys Ile Met Gly 
    450                 455                 460                 


Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr Val Trp Val Gly Phe 
465                 470                 475                 480 


Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp Ile His Ala Gly Glu 
                485                 490                 495     


Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp His Asn Met Tyr Asn 
            500                 505                 510         


Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu Met Pro 
        515                 520                 525 


<210>  3
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Pro Leu Arg Pro Arg Ala Ala Leu Leu Ala Leu Leu Ala Ser 
1               5                   10                  15      


Leu Leu Ala Ala Pro Pro Val Ala Pro Ala Glu Ala Pro His Leu Val 
            20                  25                  30          


Gln Val Asp Ala Ala Arg Ala Leu Trp Pro Leu Arg Arg Phe Trp Arg 
        35                  40                  45              


Ser Thr Gly Phe Cys Pro Pro Leu Pro His Ser Gln Ala Asp Gln Tyr 
    50                  55                  60                  


Val Leu Ser Trp Asp Gln Gln Leu Asn Leu Ala Tyr Val Gly Ala Val 
65                  70                  75                  80  


Pro His Arg Gly Ile Lys Gln Val Arg Thr His Trp Leu Leu Glu Leu 
                85                  90                  95      


Val Thr Thr Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr Asn Phe Thr 
            100                 105                 110         


His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln Leu Leu Pro 
        115                 120                 125             


Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His Phe Thr Asp Phe Glu 
    130                 135                 140                 


Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu Val Ser Ser Leu Ala 
145                 150                 155                 160 


Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His Val Ser Lys Trp Asn 
                165                 170                 175     


Phe Glu Thr Trp Asn Glu Pro Asp His His Asp Phe Asp Asn Val Ser 
            180                 185                 190         


Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser Glu Gly 
        195                 200                 205             


Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly Asp Ser 
    210                 215                 220                 


Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu Arg His 
225                 230                 235                 240 


Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly Val Arg Leu 
                245                 250                 255     


Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg Ser Ser Ile Ser Ile 
            260                 265                 270         


Leu Glu Gln Glu Lys Val Val Ala Gln Gln Ile Arg Gln Leu Phe Pro 
        275                 280                 285             


Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp Glu Ala Asp Pro Leu Val 
    290                 295                 300                 


Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala Asp Val Thr Tyr Ala Ala 
305                 310                 315                 320 


Met Val Val Lys Val Ile Ala Gln His Gln Asn Leu Leu Leu Ala Asn 
                325                 330                 335     


Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu Ser Asn Asp Asn Ala Phe 
            340                 345                 350         


Leu Ser Tyr His Pro His Pro Phe Ala Gln Arg Thr Leu Thr Ala Arg 
        355                 360                 365             


Phe Gln Val Asn Asn Thr Arg Pro Pro His Val Gln Leu Leu Arg Lys 
    370                 375                 380                 


Pro Val Leu Thr Ala Met Gly Leu Leu Ala Leu Leu Asp Glu Glu Gln 
385                 390                 395                 400 


Leu Trp Ala Glu Val Ser Gln Ala Gly Thr Val Leu Asp Ser Asn His 
                405                 410                 415     


Thr Val Gly Val Leu Ala Ser Ala His Arg Pro Gln Gly Pro Ala Asp 
            420                 425                 430         


Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala Ser Asp Asp Thr Arg Ala 
        435                 440                 445             


His Pro Asn Arg Ser Val Ala Val Thr Leu Arg Leu Arg Gly Val Pro 
    450                 455                 460                 


Pro Gly Pro Gly Leu Val Tyr Val Thr Arg Tyr Leu Asp Asn Gly Leu 
465                 470                 475                 480 


Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu Gly Arg Pro Val Phe Pro 
                485                 490                 495     


Thr Ala Glu Gln Phe Arg Arg Met Arg Ala Ala Glu Asp Pro Val Ala 
            500                 505                 510         


Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly Arg Leu Thr Leu Arg Pro 
        515                 520                 525             


Ala Leu Arg Leu Pro Ser Leu Leu Leu Val His Val Cys Ala Arg Pro 
    530                 535                 540                 


Glu Lys Pro Pro Gly Gln Val Thr Arg Leu Arg Ala Leu Pro Leu Thr 
545                 550                 555                 560 


Gln Gly Gln Leu Val Leu Val Trp Ser Asp Glu His Val Gly Ser Lys 
                565                 570                 575     


Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser Gln Asp Gly Lys Ala Tyr 
            580                 585                 590         


Thr Pro Val Ser Arg Lys Pro Ser Thr Phe Asn Leu Phe Val Phe Ser 
        595                 600                 605             


Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr Arg Val Arg Ala Leu Asp 
    610                 615                 620                 


Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp Pro Val Pro Tyr Leu Glu 
625                 630                 635                 640 


Val Pro Val Pro Arg Gly Pro Pro Ser Pro Gly Asn Pro 
                645                 650             


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sulfatase motif


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = Any amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Cys or Ser

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = Pro or Ala

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = Any amino acid

<400>  4

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sulfatase motifs


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = Any amino acid or absent

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Formylglycine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = Any amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = Pro or Ala

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = Any amino acid

<400>  5

Xaa Gly Xaa Xaa Xaa 
1               5   


<210>  6
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary Gly Ser linker

<400>  6

Gly Ser Gly Ser 
1               


<210>  7
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary Gly Ser linker

<400>  7

Gly Gly Ser Gly 
1               


<210>  8
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary Gly Ser linker

<400>  8

Gly Gly Gly Ser 
1               


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary Gly Ser linker

<400>  9

Gly Gly Gly Gly Ser 
1               5   


<210>  10
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary Gly Asn linker

<400>  10

Gly Asn Gly Asn 
1               


<210>  11
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary Gly Asn linker

<400>  11

Gly Gly Asn Gly 
1               


<210>  12
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary Gly Asn linker

<400>  12

Gly Gly Gly Asn 
1               


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary Gly Asn linker

<400>  13

Gly Gly Gly Gly Asn 
1               5   


<210>  14
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - thrombin cleavable

<400>  14

Gly Arg Gly Asp 
1               


<210>  15
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - thrombin cleavable

<400>  15

Gly Arg Gly Asp Asn Pro 
1               5       


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - thrombin cleavable

<400>  16

Gly Arg Gly Asp Ser 
1               5   


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - thrombin cleavable

<400>  17

Gly Arg Gly Asp Ser Pro Lys 
1               5           


<210>  18
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - elastase cleavable

<400>  18

Ala Ala Pro Val 
1               


<210>  19
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - elastase cleavable

<400>  19

Ala Ala Pro Leu 
1               


<210>  20
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - elastase cleavable

<400>  20

Ala Ala Pro Phe 
1               


<210>  21
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - elastase cleavable

<400>  21

Ala Ala Pro Ala 
1               


<210>  22
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - elastase cleavable

<400>  22

Ala Tyr Leu Val 
1               


<210>  23
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - matrix metalloproteinase 
       cleavable


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa = Any amino acid

<400>  23

Gly Pro Xaa Gly Pro Xaa 
1               5       


<210>  24
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - matrix metalloproteinase 
       cleavable


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa = Any amino acid

<400>  24

Gly Pro Leu Gly Pro Xaa 
1               5       


<210>  25
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - matrix metalloproteinase 
       cleavable


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa = Any amino acid

<400>  25

Gly Pro Ile Gly Pro Xaa 
1               5       


<210>  26
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - matrix metalloproteinase 
       cleavable


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = Any amino acid

<400>  26

Ala Pro Gly Leu Xaa 
1               5   


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - collagenase cleavable


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = Any amino acid

<400>  27

Pro Leu Gly Pro Asp Arg Xaa 
1               5           


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - collagenase cleavable


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = Any amino acid

<400>  28

Pro Leu Gly Leu Leu Gly Xaa 
1               5           


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - collagenase cleavable

<400>  29

Pro Gln Gly Ile Ala Gly Trp 
1               5           


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - collagenase cleavable

<400>  30

Pro Leu Gly Cys His 
1               5   


<210>  31
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - collagenase cleavable

<400>  31

Pro Leu Gly Leu Tyr Ala 
1               5       


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - collagenase cleavable

<400>  32

Pro Leu Ala Leu Trp Ala Arg 
1               5           


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - collagenase cleavable

<400>  33

Pro Leu Ala Tyr Trp Ala Arg 
1               5           


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - stromelysin cleavable

<400>  34

Pro Tyr Ala Tyr Tyr Met Arg 
1               5           


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - gelatinase cleavable

<400>  35

Pro Leu Gly Met Tyr Ser Arg 
1               5           


<210>  36
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - angiotensin converting enzyme 
       cleavable

<400>  36

Gly Asp Lys Pro 
1               


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - angiotensin converting enzyme 
       cleavable

<400>  37

Gly Ser Asp Lys Pro 
1               5   


<210>  38
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - cathepsin B cleavable

<400>  38

Ala Leu Ala Leu 
1               


<210>  39
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically degradable linker - cathepsin B cleavable

<400>  39

Gly Phe Leu Gly 
1               


