                         SEQUENCE LISTING

<110>  The Board of Regents of the University of Texas System
       Doiron, Bruno
       DeFronze, Ralph A.
 
<120>  METHODS AND COMPOSITIONS FOR IN VIVO INDUCTION OF PANCREATIC BETA
        CELLS

<130>  STTM0009WO / 2012.021.HSCS

<150>  US 61/678,077
<151>  2012-07-31

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  703
<212>  DNA
<213>  mus musculus

<400>  1
tggcttatcg aaattaatac gactcactat agggagaccc aagcttagat ctgtttaaac       60

ctcgagaatt catggctgtg gatactacaa ggaggggagc ccagtcgttg actctggtag      120

agcagatcct ggcagagttc cagctgcagg aggaagacct gaagaaggtg atgagccgga      180

tgcagaagga gatggaccgt ggcctgaagc tggagaccca tcaggaggcc agtgtaaaga      240

tgttgcccac ctacgtgcgt tccaccccag aaggctcaga agttggagac tttctctcct      300

tagacctggg aggaaccaac ttcagggtga tgctggtgaa agtgggggag ggggaggcag      360

gacagtggag cgtgaagacg aaacaccaga tgtattccat ccccgaggac gccatgacgg      420

gcactgcgga gatgctcttt gactacatct ctgagtgcat ctctgacttc ctggacaagc      480

atcagatgaa acacaagaaa ctacccctgg gcttcacctt ctccttccct gtaaggcacg      540

aagacataga caagggcatc ctgctcaact ggaccaaggg cttcaaggcc tccggagcag      600

aagggaacaa catcgtggga cttctccgag atgctatcaa gaggagaggg gactttgaga      660

tggatgtggt ggcaatggtg aatgacacgg tggccacaat gat                        703


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  2
gccaggacat tcgacatgaa                                                   20


<210>  3
<211>  254
<212>  DNA
<213>  Homo sapiens

<400>  3
ccatgaacag tgaggagcag tactacgcgg ccacacagct ctacaaggac ccgtgcgcat       60

tccagagggg cccggtgcca gagttcagcg ctaacccccc tgcgtgcctg tacatgggcc      120

gccagccccc acctccgccg ccaccccagt ttacaagctc gctgggatca ctggagcagg      180

gaagtcctcc ggacatctcc ccatacaaag tgcccccgct cgcctccgac gacccggctg      240

gcgctcacct ccac                                                        254


<210>  4
<211>  1398
<212>  DNA
<213>  Homo sapiens

<400>  4
atgctggacg acagagccag gatggaggcc gccaagaagg agaaggtaga gcagatcctg       60

gcagagttcc agctgcagga ggaggacctg aagaaggtga tgagacggat gcagaaggag      120

atggaccgcg gcctgaggct ggagacccat gaagaggcca gtgtgaagat gctgcccacc      180

tacgtgcgct ccaccccaga aggctcagaa gtcggggact tcctctccct ggacctgggt      240

ggcactaact tcagggtgat gctggtgaag gtgggagaag gtgaggaggg gcagtggagc      300

gtgaagacca aacaccagat gtactccatc cccgaggacg ccatgaccgg cactgctgag      360

atgctcttcg actacatctc tgagtgcatc tccgacttcc tggacaagca tcagatgaaa      420

cacaagaagc tgcccctggg cttcaccttc tcctttcctg tgaggcacga agacatcgat      480

aagggcatcc ttctcaactg gaccaagggc ttcaaggcct caggagcaga agggaacaat      540

gtcgtggggc ttctgcgaga cgctatcaaa cggagagggg actttgaaat ggatgtggtg      600

gcaatggtga atgacacggt ggccacgatg atctcctgct actacgaaga ccatcagtgc      660

gaggtcggca tgatcgtggg cacgggctgc aatgcctgct acatggagga gatgcagaat      720

gtggagctgg tggaggggga cgagggccgc atgtgcgtca ataccgagtg gggcgccttc      780

ggggactccg gcgagctgga cgagttcctg ctggagtatg accgcctggt ggacgagagc      840

tctgcaaacc ccggtcagca gctgtatgag aagctcatag gtggcaagta catgggcgag      900

ctggtgcggc ttgtgctgct caggctcgtg gacgaaaacc tgctcttcca cggggaggcc      960

tccgagcagc tgcgcacacg cggagccttc gagacgcgct tcgtgtcgca ggtggagagc     1020

gacacgggcg accgcaagca gatctacaac atcctgagca cgctggggct gcgaccctcg     1080

accaccgact gcgacatcgt gcgccgcgcc tgcgagagcg tgtctacgcg cgctgcgcac     1140

atgtgctcgg cggggctggc gggcgtcatc aaccgcatgc gcgagagccg cagcgaggac     1200

gtaatgcgca tcactgtggg cgtggatggc tccgtgtaca agctgcaccc cagcttcaag     1260

gagcggttcc atgccagcgt gcgcaggctg acgcccagct gcgagatcac cttcatcgag     1320

tcggaggagg gcagtggccg gggcgcggcc ctggtctcgg cggtggcctg taagaaggcc     1380

tgtatgctgg gccagtga                                                   1398


<210>  5
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Leu Asp Asp Arg Ala Arg Met Glu Ala Ala Lys Lys Glu Lys Val 
1               5                   10                  15      


Glu Gln Ile Leu Ala Glu Phe Gln Leu Gln Glu Glu Asp Leu Lys Lys 
            20                  25                  30          


Val Met Arg Arg Met Gln Lys Glu Met Asp Arg Gly Leu Arg Leu Glu 
        35                  40                  45              


Thr His Glu Glu Ala Ser Val Lys Met Leu Pro Thr Tyr Val Arg Ser 
    50                  55                  60                  


Thr Pro Glu Gly Ser Glu Val Gly Asp Phe Leu Ser Leu Asp Leu Gly 
65                  70                  75                  80  


Gly Thr Asn Phe Arg Val Met Leu Val Lys Val Gly Glu Gly Glu Glu 
                85                  90                  95      


Gly Gln Trp Ser Val Lys Thr Lys His Gln Met Tyr Ser Ile Pro Glu 
            100                 105                 110         


Asp Ala Met Thr Gly Thr Ala Glu Met Leu Phe Asp Tyr Ile Ser Glu 
        115                 120                 125             


Cys Ile Ser Asp Phe Leu Asp Lys His Gln Met Lys His Lys Lys Leu 
    130                 135                 140                 


Pro Leu Gly Phe Thr Phe Ser Phe Pro Val Arg His Glu Asp Ile Asp 
145                 150                 155                 160 


Lys Gly Ile Leu Leu Asn Trp Thr Lys Gly Phe Lys Ala Ser Gly Ala 
                165                 170                 175     


Glu Gly Asn Asn Val Val Gly Leu Leu Arg Asp Ala Ile Lys Arg Arg 
            180                 185                 190         


Gly Asp Phe Glu Met Asp Val Val Ala Met Val Asn Asp Thr Val Ala 
        195                 200                 205             


Thr Met Ile Ser Cys Tyr Tyr Glu Asp His Gln Cys Glu Val Gly Met 
    210                 215                 220                 


Ile Val Gly Thr Gly Cys Asn Ala Cys Tyr Met Glu Glu Met Gln Asn 
225                 230                 235                 240 


Val Glu Leu Val Glu Gly Asp Glu Gly Arg Met Cys Val Asn Thr Glu 
                245                 250                 255     


Trp Gly Ala Phe Gly Asp Ser Gly Glu Leu Asp Glu Phe Leu Leu Glu 
            260                 265                 270         


Tyr Asp Arg Leu Val Asp Glu Ser Ser Ala Asn Pro Gly Gln Gln Leu 
        275                 280                 285             


Tyr Glu Lys Leu Ile Gly Gly Lys Tyr Met Gly Glu Leu Val Arg Leu 
    290                 295                 300                 


Val Leu Leu Arg Leu Val Asp Glu Asn Leu Leu Phe His Gly Glu Ala 
305                 310                 315                 320 


Ser Glu Gln Leu Arg Thr Arg Gly Ala Phe Glu Thr Arg Phe Val Ser 
                325                 330                 335     


Gln Val Glu Ser Asp Thr Gly Asp Arg Lys Gln Ile Tyr Asn Ile Leu 
            340                 345                 350         


Ser Thr Leu Gly Leu Arg Pro Ser Thr Thr Asp Cys Asp Ile Val Arg 
        355                 360                 365             


Arg Ala Cys Glu Ser Val Ser Thr Arg Ala Ala His Met Cys Ser Ala 
    370                 375                 380                 


Gly Leu Ala Gly Val Ile Asn Arg Met Arg Glu Ser Arg Ser Glu Asp 
385                 390                 395                 400 


Val Met Arg Ile Thr Val Gly Val Asp Gly Ser Val Tyr Lys Leu His 
                405                 410                 415     


Pro Ser Phe Lys Glu Arg Phe His Ala Ser Val Arg Arg Leu Thr Pro 
            420                 425                 430         


Ser Cys Glu Ile Thr Phe Ile Glu Ser Glu Glu Gly Ser Gly Arg Gly 
        435                 440                 445             


Ala Ala Leu Val Ser Ala Val Ala Cys Lys Lys Ala Cys Met Leu Gly 
    450                 455                 460                 


Gln 
465 


<210>  6
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asn Gly Glu Glu Gln Tyr Tyr Ala Ala Thr Gln Leu Tyr Lys Asp 
1               5                   10                  15      


Pro Cys Ala Phe Gln Arg Gly Pro Ala Pro Glu Phe Ser Ala Ser Pro 
            20                  25                  30          


Pro Ala Cys Leu Tyr Met Gly Arg Gln Pro Pro Pro Pro Pro Pro His 
        35                  40                  45              


Pro Phe Pro Gly Ala Leu Gly Ala Leu Glu Gln Gly Ser Pro Pro Asp 
    50                  55                  60                  


Ile Ser Pro Tyr Glu Val Pro Pro Leu Ala Asp Asp Pro Ala Val Ala 
65                  70                  75                  80  


His Leu His His His Leu Pro Ala Gln Leu Ala Leu Pro His Pro Pro 
                85                  90                  95      


Ala Gly Pro Phe Pro Glu Gly Ala Glu Pro Gly Val Leu Glu Glu Pro 
            100                 105                 110         


Asn Arg Val Gln Leu Pro Phe Pro Trp Met Lys Ser Thr Lys Ala His 
        115                 120                 125             


Ala Trp Lys Gly Gln Trp Ala Gly Gly Ala Tyr Ala Ala Glu Pro Glu 
    130                 135                 140                 


Glu Asn Lys Arg Thr Arg Thr Ala Tyr Thr Arg Ala Gln Leu Leu Glu 
145                 150                 155                 160 


Leu Glu Lys Glu Phe Leu Phe Asn Lys Tyr Ile Ser Arg Pro Arg Arg 
                165                 170                 175     


Val Glu Leu Ala Val Met Leu Asn Leu Thr Glu Arg His Ile Lys Ile 
            180                 185                 190         


Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Glu Asp Lys Lys 
        195                 200                 205             


Arg Gly Gly Gly Thr Ala Val Gly Gly Gly Gly Val Ala Glu Pro Glu 
    210                 215                 220                 


Gln Asp Cys Ala Val Thr Ser Gly Glu Glu Leu Leu Ala Leu Pro Pro 
225                 230                 235                 240 


Pro Pro Pro Pro Gly Gly Ala Val Pro Pro Ala Ala Pro Val Ala Ala 
                245                 250                 255     


Arg Glu Gly Arg Leu Pro Pro Gly Leu Ser Ala Ser Pro Gln Pro Ser 
            260                 265                 270         


Ser Val Ala Pro Arg Arg Pro Gln Glu Pro Arg 
        275                 280             


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  7

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  8

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10  


