                               SEQUENCE LISTING

<110> THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
 
<120> MODULATION OF THE IMMUNE RESPONSE

<130> 043214-073951-PCT

<140> PCT/US2013/052612
<141> 2013-07-30

<150> 61/677,596
<151> 2012-07-31

<160> 34    

<170> PatentIn version 3.5

<210> 1
<211> 301
<212> PRT
<213> Homo sapiens

<400> 1
Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Leu Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly 
        195                 200                 205             


Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe 
    210                 215                 220                 


Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile 
225                 230                 235                 240 


Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu 
                245                 250                 255     


Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr 
            260                 265                 270         


Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln 
        275                 280                 285             


Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro 
    290                 295                 300     


<210> 2
<211> 301
<212> PRT
<213> Homo sapiens

<400> 2
Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly 
        195                 200                 205             


Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe 
    210                 215                 220                 


Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile 
225                 230                 235                 240 


Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu 
                245                 250                 255     


Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr 
            260                 265                 270         


Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln 
        275                 280                 285             


Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro 
    290                 295                 300     


<210> 3
<211> 197
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Met Phe Ser Gly Leu Thr Leu Asn Cys Val Leu Leu Leu Leu Gln Leu 
1               5                   10                  15      


Leu Leu Ala Arg Ser Leu Glu Asp Gly Tyr Lys Val Glu Val Gly Lys 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Ser Tyr Thr Leu Pro Thr Ser Gly Thr Leu 
        35                  40                  45              


Val Pro Met Cys Trp Gly Lys Gly Phe Cys Pro Trp Ser Gln Cys Thr 
    50                  55                  60                  


Asn Glu Leu Leu Arg Thr Asp Glu Arg Asn Val Thr Tyr Gln Lys Ser 
65                  70                  75                  80  


Ser Arg Tyr Gln Leu Lys Gly Asp Leu Asn Lys Gly Asp Val Ser Leu 
                85                  90                  95      


Ile Ile Lys Asn Val Thr Leu Asp Asp His Gly Thr Tyr Cys Cys Arg 
            100                 105                 110         


Ile Gln Phe Pro Gly Leu Met Asn Asp Lys Lys Leu Glu Leu Lys Leu 
        115                 120                 125             


Asp Ile Lys Ala Gly Tyr Ser Cys Lys Lys Lys Lys Leu Ser Ser Leu 
    130                 135                 140                 


Ser Leu Ile Thr Leu Ala Asn Leu Pro Pro Gly Gly Leu Ala Asn Ala 
145                 150                 155                 160 


Gly Ala Val Arg Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu 
                165                 170                 175     


Asn Val Tyr Glu Val Glu Asn Ser Asn Glu Tyr Tyr Cys Tyr Val Asn 
            180                 185                 190         


Ser Gln Gln Pro Ser 
        195         


<210> 4
<211> 281
<212> PRT
<213> Mus musculus

<400> 4
Met Phe Ser Gly Leu Thr Leu Asn Cys Val Leu Leu Leu Leu Gln Leu 
1               5                   10                  15      


Leu Leu Ala Arg Ser Leu Glu Asp Gly Tyr Lys Val Glu Val Gly Lys 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Ser Tyr Thr Leu Pro Thr Ser Gly Thr Leu 
        35                  40                  45              


Val Pro Met Cys Trp Gly Lys Gly Phe Cys Pro Trp Ser Gln Cys Thr 
    50                  55                  60                  


Asn Glu Leu Leu Arg Thr Asp Glu Arg Asn Val Thr Tyr Gln Lys Ser 
65                  70                  75                  80  


Ser Arg Tyr Gln Leu Lys Gly Asp Leu Asn Lys Gly Asp Val Ser Leu 
                85                  90                  95      


Ile Ile Lys Asn Val Thr Leu Asp Asp His Gly Thr Tyr Cys Cys Arg 
            100                 105                 110         


Ile Gln Phe Pro Gly Leu Met Asn Asp Lys Lys Leu Glu Leu Lys Leu 
        115                 120                 125             


Asp Ile Lys Ala Ala Lys Val Thr Pro Ala Gln Thr Ala His Gly Asp 
    130                 135                 140                 


Ser Thr Thr Ala Ser Pro Arg Thr Leu Thr Thr Glu Arg Asn Gly Ser 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Val Thr Leu His Asn Asn Asn Gly Thr Lys Ile 
                165                 170                 175     


Ser Thr Trp Ala Asp Glu Ile Lys Asp Ser Gly Glu Thr Ile Arg Thr 
            180                 185                 190         


Ala Ile His Ile Gly Val Gly Val Ser Ala Gly Leu Thr Leu Ala Leu 
        195                 200                 205             


Ile Ile Gly Val Leu Ile Leu Lys Trp Tyr Ser Cys Lys Lys Lys Lys 
    210                 215                 220                 


Leu Ser Ser Leu Ser Leu Ile Thr Leu Ala Asn Leu Pro Pro Gly Gly 
225                 230                 235                 240 


Leu Ala Asn Ala Gly Ala Val Arg Ile Arg Ser Glu Glu Asn Ile Tyr 
                245                 250                 255     


Thr Ile Glu Glu Asn Val Tyr Glu Val Glu Asn Ser Asn Glu Tyr Tyr 
            260                 265                 270         


Cys Tyr Val Asn Ser Gln Gln Pro Ser 
        275                 280     


<210> 5
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Ser Ser His Gly Met Ser 
1               5       


<210> 6
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 7
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
His Asp Phe Asp Tyr Asp Ala Ala Trp Phe Ala Tyr 
1               5                   10          


<210> 8
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Ser Ala Asn Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210> 9
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Leu Thr Ser Asn Leu Ala Ser 
1               5           


<210> 10
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Gln Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210> 11
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Ser Phe Tyr Gly Met Ser 
1               5       


<210> 12
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Ser Asp Tyr Tyr Leu Tyr 
1               5       


<210> 13
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Thr Phe Ser Gly Gly Gly Asn Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 14
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Thr Ile Ser Val Gly Gly Gly Asn Thr Ser Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 15
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
His Gly Gly Leu Pro Phe Tyr Ala Met Asp Tyr 
1               5                   10      


<210> 16
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Gly Leu Thr Thr Gly Pro Ala Trp Phe Ala Tyr 
1               5                   10      


<210> 17
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Ser Val Ser Ser Ser Ile Ser Ser Ser Asn Leu His 
1               5                   10          


<210> 18
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Lys Ser Ser Gln Ser Leu Leu Asn Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 19
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Arg Ala Ser Gln Lys Ile Ser Gly Tyr Leu Ser 
1               5                   10      


<210> 20
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Ser Val Ser Ser Ser Ile Ser Ser Ser Asn Leu His 
1               5                   10          


<210> 21
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Phe Ala Ser Thr Arg Glu Ser 
1               5           


<210> 22
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Ala Ala Ser Thr Leu Asp Ser 
1               5           


<210> 23
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Gln Gln Trp Ser Ser His Pro Phe Thr 
1               5                   


<210> 24
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Gln Gln His Tyr Ser Thr Pro Trp Thr 
1               5                   


<210> 25
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Leu Gln Tyr Ala Ser Ser Leu Met Tyr Thr 
1               5                   10  


<210> 26
<211> 417
<212> PRT
<213> Homo sapiens

<400> 26
Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr 
                325                 330                 335     


Val Thr Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp 
            340                 345                 350         


Thr Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 
        355                 360                 365             


Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn 
    370                 375                 380                 


Pro Val Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn 
385                 390                 395                 400 


Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Cys 
                405                 410                 415     


Lys 
    


<210> 27
<211> 321
<212> PRT
<213> Homo sapiens

<400> 27
Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Gly 
305                 310                 315                 320 


Lys 
    


<210> 28
<211> 351
<212> PRT
<213> Homo sapiens

<400> 28
Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Ser Pro Val Leu Gly Glu Asp Glu Ala Val Pro Gly Gln His His Pro 
                325                 330                 335     


Gln His Lys Pro Cys Gln Glu Gly Gly Cys Trp Asp Val Leu Val 
            340                 345                 350     


<210> 29
<211> 526
<212> PRT
<213> Homo sapiens

<400> 29
Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr 
                325                 330                 335     


Val Thr Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp 
            340                 345                 350         


Thr Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 
        355                 360                 365             


Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn 
    370                 375                 380                 


Pro Val Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn 
385                 390                 395                 400 


Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr 
                405                 410                 415     


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
            420                 425                 430         


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
        435                 440                 445             


Ala Cys Phe Leu His Phe Gly Lys Thr Gly Arg Ala Ser Asp Gln Arg 
    450                 455                 460                 


Asp Leu Thr Glu His Lys Pro Ser Val Ser Asn His Thr Gln Asp His 
465                 470                 475                 480 


Ser Asn Asp Pro Pro Asn Lys Met Asn Glu Val Thr Tyr Ser Thr Leu 
                485                 490                 495     


Asn Phe Glu Ala Gln Gln Pro Thr Gln Pro Thr Ser Ala Ser Pro Ser 
            500                 505                 510         


Leu Thr Ala Thr Glu Ile Ile Tyr Ser Glu Val Lys Lys Gln 
        515                 520                 525     


<210> 30
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Cys Pro Val Phe Glu Cys Gly Asn Val Val Leu Arg Thr Asp Glu Arg 
1               5                   10                  15      


Asp Val Asn Tyr 
            20  


<210> 31
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Cys Pro Val Phe Glu Ser Gly Ser Gly Arg Ile Gln Glu Pro Gly Ile 
1               5                   10                  15      


Met 
    


<210> 32
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Ser Gly Ser Gly 
1               


<210> 33
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 33
His His His His His His 
1               5       


<210> 34
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Cys Pro Val Phe Glu Ser Gly Ser Gly Ile Gln Ile Pro Gly Ile Met 
1               5                   10                  15      


Asn 
    


