                         SEQUENCE LISTING

<110>  Isis Innovation Limited
 
<120>  Protein

<130>  JA63318P.WOP

<150>  1213672.7
<151>  2012-08-01

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  641
<212>  PRT
<213>  Human

<400>  1

Met Ala Leu Ser Leu Glu Glu Phe Val His Ser Leu Asp Leu Arg Thr 
1               5                   10                  15      


Leu Pro Arg Val Leu Glu Ile Gln Ala Gly Ile Tyr Leu Glu Gly Ser 
            20                  25                  30          


Ile Tyr Glu Met Phe Gly Asn Glu Cys Cys Phe Ser Thr Gly Glu Val 
        35                  40                  45              


Ile Lys Ile Thr Gly Leu Lys Val Lys Lys Ile Ile Ala Glu Ile Cys 
    50                  55                  60                  


Glu Gln Ile Glu Gly Cys Glu Ser Leu Gln Pro Phe Glu Leu Pro Met 
65                  70                  75                  80  


Asn Phe Pro Gly Leu Phe Lys Ile Val Ala Asp Lys Thr Pro Tyr Leu 
                85                  90                  95      


Thr Met Glu Glu Ile Thr Arg Thr Ile His Ile Gly Pro Ser Arg Leu 
            100                 105                 110         


Gly His Pro Cys Phe Tyr His Gln Lys Asp Ile Lys Leu Glu Asn Leu 
        115                 120                 125             


Ile Ile Lys Gln Gly Glu Gln Ile Met Leu Asn Ser Val Glu Glu Ile 
    130                 135                 140                 


Asp Gly Glu Ile Met Val Ser Cys Ala Val Ala Arg Asn His Gln Thr 
145                 150                 155                 160 


His Ser Phe Asn Leu Pro Leu Ser Gln Glu Gly Glu Phe Tyr Glu Cys 
                165                 170                 175     


Glu Asp Glu Arg Ile Tyr Thr Leu Lys Glu Ile Val Glu Trp Lys Ile 
            180                 185                 190         


Pro Lys Asn Arg Thr Arg Thr Val Asn Leu Thr Asp Phe Ser Asn Lys 
        195                 200                 205             


Trp Asp Ser Thr Asn Pro Phe Pro Lys Asp Phe Tyr Gly Thr Leu Ile 
    210                 215                 220                 


Leu Lys Pro Val Tyr Glu Ile Gln Gly Val Met Lys Phe Arg Lys Asp 
225                 230                 235                 240 


Ile Ile Arg Ile Leu Pro Ser Leu Asp Val Glu Val Lys Asp Ile Thr 
                245                 250                 255     


Asp Ser Tyr Asp Ala Asn Trp Phe Leu Gln Leu Leu Ser Thr Glu Asp 
            260                 265                 270         


Leu Phe Glu Met Thr Ser Lys Glu Phe Pro Ile Val Thr Glu Val Ile 
        275                 280                 285             


Glu Ala Pro Glu Gly Asn His Leu Pro Gln Ser Ile Leu Gln Pro Gly 
    290                 295                 300                 


Lys Thr Ile Val Ile His Lys Lys Tyr Gln Ala Ser Arg Ile Leu Ala 
305                 310                 315                 320 


Ser Glu Ile Arg Ser Asn Phe Pro Lys Arg His Phe Leu Ile Pro Thr 
                325                 330                 335     


Ser Tyr Lys Gly Lys Phe Lys Arg Arg Pro Arg Glu Phe Pro Thr Ala 
            340                 345                 350         


Tyr Asp Leu Glu Ile Ala Lys Ser Glu Lys Glu Pro Leu His Val Val 
        355                 360                 365             


Ala Thr Lys Ala Phe His Ser Pro His Asp Lys Leu Ser Ser Val Ser 
    370                 375                 380                 


Val Gly Asp Gln Phe Leu Val His Gln Ser Glu Thr Thr Glu Val Leu 
385                 390                 395                 400 


Cys Glu Gly Ile Lys Lys Val Val Asn Val Leu Ala Cys Glu Lys Ile 
                405                 410                 415     


Leu Lys Lys Ser Tyr Glu Ala Ala Leu Leu Pro Leu Tyr Met Glu Gly 
            420                 425                 430         


Gly Phe Val Glu Val Ile His Asp Lys Lys Gln Tyr Pro Ile Ser Glu 
        435                 440                 445             


Leu Cys Lys Gln Phe Arg Leu Pro Phe Asn Val Lys Val Ser Val Arg 
    450                 455                 460                 


Asp Leu Ser Ile Glu Glu Asp Val Leu Ala Ala Thr Pro Gly Leu Gln 
465                 470                 475                 480 


Leu Glu Glu Asp Ile Thr Asp Ser Tyr Leu Leu Ile Ser Asp Phe Ala 
                485                 490                 495     


Asn Pro Thr Glu Cys Trp Glu Ile Pro Val Gly Arg Leu Asn Met Thr 
            500                 505                 510         


Val Gln Leu Val Ser Asn Phe Ser Arg Asp Ala Glu Pro Phe Leu Val 
        515                 520                 525             


Arg Thr Leu Val Glu Glu Ile Thr Glu Glu Gln Tyr Tyr Met Met Arg 
    530                 535                 540                 


Arg Tyr Glu Ser Ser Ala Ser His Pro Pro Pro Arg Pro Pro Lys His 
545                 550                 555                 560 


Pro Ser Val Glu Glu Thr Lys Leu Thr Leu Leu Thr Leu Ala Glu Glu 
                565                 570                 575     


Arg Thr Val Asp Leu Pro Lys Ser Pro Lys Arg His His Val Asp Ile 
            580                 585                 590         


Thr Lys Lys Leu His Pro Asn Gln Ala Gly Leu Asp Ser Lys Val Leu 
        595                 600                 605             


Ile Gly Ser Gln Asn Asp Leu Val Asp Glu Glu Lys Glu Arg Ser Asn 
    610                 615                 620                 


Arg Gly Ala Thr Ala Ile Ala Glu Thr Phe Lys Asn Glu Lys His Gln 
625                 630                 635                 640 


Lys 
    


<210>  2
<211>  3983
<212>  DNA
<213>  Artificial

<220>
<223>  cDNA

<400>  2
agctactcca ccccactctg gctgtagtgt gacattcctg cctgcctgag gaagaaatgg       60

tgagcagggg ctgcaattgc agacaagtgt cacccagaag ccacaagttt ctgtgagcac      120

caggtctaca aactacccaa ggcatagcaa tggcattatc actggaagaa ttcgtccact      180

cccttgacct caggacccta cccagggttc tagaaatcca ggcaggcatc tatcttgaag      240

gctctattta tgaaatgttt ggaaatgaat gctgtttttc aacaggagaa gtgattaaaa      300

ttactggtct caaagttaag aagatcatag ctgaaatttg tgagcagatt gaaggttgtg      360

agtctctaca gccatttgaa ctgcctatga attttccagg tctttttaag attgtggctg      420

ataaaactcc ataccttact atggaagaaa tcacaaggac cattcatatt ggaccaagta      480

gactagggca tccttgcttc tatcatcaga aggatataaa actagagaac ctcatcataa      540

agcagggtga gcaaatcatg ctcaactcag ttgaagagat tgatggagaa ataatggtga      600

gctgtgcagt agcaaggaat catcaaactc actcatttaa tttgcctttg tcacaagaag      660

gagaattcta cgagtgtgaa gatgaacgta tttacactct aaaggagatt gttgaatgga      720

agattcctaa gaacagaaca agaactgtaa accttacaga tttttcaaat aagtgggact      780

caacgaatcc atttcctaaa gacttttatg gtaccctgat tctcaagcct gtttatgaaa      840

ttcaaggtgt gatgaaattt cgaaaagata taatccgcat cctccccagt ctagatgtcg      900

aagtcaaaga catcactgat tcttacgatg ctaactggtt tcttcagctg ttatcaacag      960

aagatctttt tgaaatgact agtaaagagt tccccatagt gactgaagtc atagaagcac     1020

ctgaaggaaa ccacctgccc caaagcattt tacagcctgg gaaaaccatt gtgatccaca     1080

aaaagtacca ggcatcaaga atcttagctt cagaaattag aagcaatttt cctaaaagac     1140

acttcttgat ccccactagc tataaaggca agttcaagcg gcgaccgagg gagttcccaa     1200

cggcctatga cctagagatc gctaagagtg aaaaggagcc tcttcacgtg gtggccacca     1260

aagcgtttca ttcccctcat gacaagctgt catccgtatc tgttggggac cagtttctgg     1320

tgcatcagtc agagacgact gaagtcctct gtgagggaat aaaaaaagtg gtgaatgttc     1380

tggcctgtga aaaaatcctc aaaaagtcct atgaggctgc gctgctccct ttgtacatgg     1440

aaggaggttt tgtagaggtg attcatgata agaaacagta cccgatttct gagctctgta     1500

aacagttccg tttgcccttc aatgtgaagg tgtctgtcag ggatctttcc attgaagagg     1560

acgtgttggc tgccacacca ggactgcagt tggaggagga cattacagac tcttacctac     1620

tcataagtga ctttgccaac cccacggagt gctgggaaat tcctgtgggc cgcttgaata     1680

tgactgttca gttagttagt aatttctcta gggatgcaga accatttcta gtcaggactc     1740

tggtagaaga gatcactgaa gagcaatatt acatgatgcg gagatatgaa agctcagcct     1800

cacatccccc acctcgccct ccgaaacacc cctcagtaga ggaaacaaag ttaaccctgc     1860

taaccttagc agaagaaagg acggtagacc tgcccaagtc tcccaaggct ggagtgcaat     1920

ggcgtgatct tggctcgctg caacctctgc ctcccgggtt caagcaattc tctgcctcag     1980

cctcccacgt agctgggatt acaggcaccc cccaccacgt ccagcgtcat cacgtagaca     2040

taaccaagaa acttcaccca aatcaagctg gcctggattc aaaagtactg attggtagtc     2100

agaatgattt ggtggatgaa gagaaagaaa ggagcaaccg tggggccaca gcaatagcag     2160

aaacattcaa aaatgaaaaa catcaaaaat aacaagatgt gacagaagcc acttaggcag     2220

caaacataaa tgttgcagtg aaaaaagaag ctagccttct agctgaaaaa cgagtattcc     2280

ccaatggact ccagaagaaa cttgattcat cgctgcaaag gaaagaacaa ccttaaaact     2340

tttaacagat aaaacttaca gaaacctatg atatagaatt catatagtct attctgttgt     2400

gtctaaatct gtaggcattg tgttgttgtt ctttaggacg tatttattta acttgcacat     2460

tttttcagat tcttatttct actaccaaca actaagtaat tgggaaataa ttctgtattt     2520

cagtttctga gtaaaaccag tctgaaatag gataaaagcc accaaatatt ttcttttttt     2580

tccagaattt gttttgccat tttttagtgc tatcatcatt cctaacaaga ctaacttaca     2640

gaaaaataat tatatctgac tgatttaaaa tgttcaggtt tcttatccaa atcccttgga     2700

actatggaaa ggagtttgat ttcacattca cagtgtattt acaaaatacg ctgtgtcata     2760

aatatgtttg aattccaaca gccaaagcca ttgagagtca taggagtttt ccataacctt     2820

ctcttctatg acccaacaac aagctcatga ctgaaatttc accagatttc tgagacgatg     2880

tcttaatatt ctatgtgcta tgtaccagat aattctttag atgaatgttt cttaggattg     2940

taggaaaatt atctagttaa tcataatatt tgatggaaag aaaaagacaa taaaattgta     3000

atataataaa tttggctgac aagaaaccaa agtgattctt aattagtata catcagaatg     3060

atgctcttat agttgtacca tctataaaaa ttactttaag ggctctcaca ttttaataat     3120

ttatcttatt atgtattaag tatacaggaa caatattatt tttcctttaa caaaatgaag     3180

agacaggcta tctggttaat gttacatagg aatttaatag taatgcttga acttcatcca     3240

tagatcatac tctgtacaaa atttgttagc taacatccta tctcataatt attttatgtt     3300

ttgtggagaa atttgttgat tttgtaccaa agtgtttctg aagacaataa attgtgagtc     3360

aactttagaa caaaaaaaat tagagttttt tcaatgttta tattctgatt aagcttactt     3420

taccttacat tttttctaag taacaatgaa tcctgatttc tagtgtccta aaaattgctt     3480

agtgatttga ttgtggtaat atcatttctt atctacaatg tctaaagttt tatgggacag     3540

tttttctttt atttattttg cctgtttgtg cagataagaa cagaaacttt tctaagaccc     3600

acatttggtt attgaaggcc acagcgaatc ttaacctaac agccttgaca aactgcacca     3660

taggtgtttt tagactcata taatttgtta tttttcaaac aatagtgaat aattaatatt     3720

tttgtttgga atttgagaac aattaaattt gtacttttag taactaccat tctttgatta     3780

gaaaattaag agaatgcata tcttactttg gttgtaaatt atcaagggct ttctaataga     3840

aatcatatat aacatttcta aatataagtc ctttcacata ctgtgtttcc agttgtcttg     3900

atattgaaaa gtgtaataaa cttcatgctc acctattgga gatttgggaa ggttgaaaat     3960

aaacttccta atttttattt gta                                             3983


<210>  3
<211>  644
<212>  PRT
<213>  Artificial

<220>
<223>  Themis protein amino acids 1-26 with N-terminal polyhistidine tag

<400>  3

Met Lys His His His His His His Pro Met Lys Ile Glu Glu Gly Lys 
1               5                   10                  15      


Leu Val Ile Trp Ile Asn Gly Asp Lys Gly Tyr Asn Gly Leu Ala Glu 
            20                  25                  30          


Val Gly Lys Lys Phe Glu Lys Asp Thr Gly Ile Lys Val Thr Val Glu 
        35                  40                  45              


His Pro Asp Lys Leu Glu Glu Lys Phe Pro Gln Val Ala Ala Thr Gly 
    50                  55                  60                  


Asp Gly Pro Asp Ile Ile Phe Trp Ala His Asp Arg Phe Gly Gly Tyr 
65                  70                  75                  80  


Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr Pro Asp Lys Ala Phe Gln 
                85                  90                  95      


Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala Val Arg Tyr Asn Gly Lys 
            100                 105                 110         


Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala Leu Ser Leu Ile Tyr Asn 
        115                 120                 125             


Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr Trp Glu Glu Ile Pro Ala 
    130                 135                 140                 


Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys Ser Ala Leu Met Phe Asn 
145                 150                 155                 160 


Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu Ile Ala Ala Asp Gly Gly 
                165                 170                 175     


Tyr Ala Phe Lys Tyr Glu Asn Gly Lys Tyr Asp Ile Lys Asp Gly Val 
            180                 185                 190         


Asp Asn Ala Gly Ala Lys Ala Gly Leu Thr Phe Leu Val Asp Leu Ile 
        195                 200                 205             


Lys Asn Lys His Met Asn Ala Asp Thr Asp Tyr Ser Ile Ala Glu Ala 
    210                 215                 220                 


Ala Phe Asn Lys Gly Glu Thr Ala Met Thr Ile Asn Gly Pro Trp Ala 
225                 230                 235                 240 


Trp Ser Asn Ile Asp Thr Ser Lys Val Asn Tyr Gly Val Thr Val Leu 
                245                 250                 255     


Pro Thr Phe Lys Gly Gln Pro Ser Lys Pro Phe Val Gly Val Leu Ser 
            260                 265                 270         


Ala Gly Ile Asn Ala Ala Ser Pro Asn Lys Glu Leu Ala Lys Glu Phe 
        275                 280                 285             


Leu Glu Asn Tyr Leu Leu Thr Asp Glu Gly Leu Glu Ala Val Asn Lys 
    290                 295                 300                 


Asp Lys Pro Leu Gly Ala Val Ala Leu Lys Ser Tyr Glu Glu Glu Leu 
305                 310                 315                 320 


Ala Lys Asp Pro Arg Ile Ala Ala Thr Met Glu Asn Ala Gln Lys Gly 
                325                 330                 335     


Glu Ile Met Pro Asn Ile Pro Gln Met Ser Ala Phe Trp Tyr Ala Val 
            340                 345                 350         


Arg Thr Ala Val Ile Asn Ala Ala Ser Gly Arg Gln Thr Val Asp Glu 
        355                 360                 365             


Ala Leu Lys Asp Ala Gln Thr Pro Gly Ser Leu Val Leu Phe Gln Gly 
    370                 375                 380                 


Pro Met Ala Leu Ser Leu Glu Glu Phe Val His Ser Leu Asp Leu Arg 
385                 390                 395                 400 


Thr Leu Pro Arg Val Leu Glu Ile Gln Ala Gly Ile Tyr Leu Glu Gly 
                405                 410                 415     


Ser Ile Tyr Glu Met Phe Gly Asn Glu Cys Cys Phe Ser Thr Gly Glu 
            420                 425                 430         


Val Ile Lys Ile Thr Gly Leu Lys Val Lys Lys Ile Ile Ala Glu Ile 
        435                 440                 445             


Cys Glu Gln Ile Glu Gly Cys Glu Ser Leu Gln Pro Phe Glu Leu Pro 
    450                 455                 460                 


Met Asn Phe Pro Gly Leu Phe Lys Ile Val Ala Asp Lys Thr Pro Tyr 
465                 470                 475                 480 


Leu Thr Met Glu Glu Ile Thr Arg Thr Ile His Ile Gly Pro Ser Arg 
                485                 490                 495     


Leu Gly His Pro Cys Phe Tyr His Gln Lys Asp Ile Lys Leu Glu Asn 
            500                 505                 510         


Leu Ile Ile Lys Gln Gly Glu Gln Ile Met Leu Asn Ser Val Glu Glu 
        515                 520                 525             


Ile Asp Gly Glu Ile Met Val Ser Cys Ala Val Ala Arg Asn His Gln 
    530                 535                 540                 


Thr His Ser Phe Asn Leu Pro Leu Ser Gln Glu Gly Glu Phe Tyr Glu 
545                 550                 555                 560 


Cys Glu Asp Glu Arg Ile Tyr Thr Leu Lys Glu Ile Val Glu Trp Lys 
                565                 570                 575     


Ile Pro Lys Asn Arg Thr Arg Thr Val Asn Leu Thr Asp Phe Ser Asn 
            580                 585                 590         


Lys Trp Asp Ser Thr Asn Pro Phe Pro Lys Asp Phe Tyr Gly Thr Leu 
        595                 600                 605             


Ile Leu Lys Pro Val Tyr Glu Ile Gln Gly Val Met Lys Phe Arg Lys 
    610                 615                 620                 


Asp Ile Ile Arg Ile Leu Pro Ser Leu Asp Val Glu Val Lys Asp Ile 
625                 630                 635                 640 


Thr Asp Ser Tyr 
                


<210>  4
<211>  673
<212>  PRT
<213>  Artificial

<220>
<223>  Full length Themis protein + strep tag

<400>  4

Met Ala Leu Ser Leu Glu Glu Phe Val His Ser Leu Asp Leu Arg Thr 
1               5                   10                  15      


Leu Pro Arg Val Leu Glu Ile Gln Ala Gly Ile Tyr Leu Glu Gly Ser 
            20                  25                  30          


Ile Tyr Glu Met Phe Gly Asn Glu Cys Cys Phe Ser Thr Gly Glu Val 
        35                  40                  45              


Ile Lys Ile Thr Gly Leu Lys Val Lys Lys Ile Ile Ala Glu Ile Cys 
    50                  55                  60                  


Glu Gln Ile Glu Gly Cys Glu Ser Leu Gln Pro Phe Glu Leu Pro Met 
65                  70                  75                  80  


Asn Phe Pro Gly Leu Phe Lys Ile Val Ala Asp Lys Thr Pro Tyr Leu 
                85                  90                  95      


Thr Met Glu Glu Ile Thr Arg Thr Ile His Ile Gly Pro Ser Arg Leu 
            100                 105                 110         


Gly His Pro Cys Phe Tyr His Gln Lys Asp Ile Lys Leu Glu Asn Leu 
        115                 120                 125             


Ile Ile Lys Gln Gly Glu Gln Ile Met Leu Asn Ser Val Glu Glu Ile 
    130                 135                 140                 


Asp Gly Glu Ile Met Val Ser Cys Ala Val Ala Arg Asn His Gln Thr 
145                 150                 155                 160 


His Ser Phe Asn Leu Pro Leu Ser Gln Glu Gly Glu Phe Tyr Glu Cys 
                165                 170                 175     


Glu Asp Glu Arg Ile Tyr Thr Leu Lys Glu Ile Val Glu Trp Lys Ile 
            180                 185                 190         


Pro Lys Asn Arg Thr Arg Thr Val Asn Leu Thr Asp Phe Ser Asn Lys 
        195                 200                 205             


Trp Asp Ser Thr Asn Pro Phe Pro Lys Asp Phe Tyr Gly Thr Leu Ile 
    210                 215                 220                 


Leu Lys Pro Val Tyr Glu Ile Gln Gly Val Met Lys Phe Arg Lys Asp 
225                 230                 235                 240 


Ile Ile Arg Ile Leu Pro Ser Leu Asp Val Glu Val Lys Asp Ile Thr 
                245                 250                 255     


Asp Ser Tyr Asp Ala Asn Trp Phe Leu Gln Leu Leu Ser Thr Glu Asp 
            260                 265                 270         


Leu Phe Glu Met Thr Ser Lys Glu Phe Pro Ile Val Thr Glu Val Ile 
        275                 280                 285             


Glu Ala Pro Glu Gly Asn His Leu Pro Gln Ser Ile Leu Gln Pro Gly 
    290                 295                 300                 


Lys Thr Ile Val Ile His Lys Lys Tyr Gln Ala Ser Arg Ile Leu Ala 
305                 310                 315                 320 


Ser Glu Ile Arg Ser Asn Phe Pro Lys Arg His Phe Leu Ile Pro Thr 
                325                 330                 335     


Ser Tyr Lys Gly Lys Phe Lys Arg Arg Pro Arg Glu Phe Pro Thr Ala 
            340                 345                 350         


Tyr Asp Leu Glu Ile Ala Lys Ser Glu Lys Glu Pro Leu His Val Val 
        355                 360                 365             


Ala Thr Lys Ala Phe His Ser Pro His Asp Lys Leu Ser Ser Val Ser 
    370                 375                 380                 


Val Gly Asp Gln Phe Leu Val His Gln Ser Glu Thr Thr Glu Val Leu 
385                 390                 395                 400 


Cys Glu Gly Ile Lys Lys Val Val Asn Val Leu Ala Cys Glu Lys Ile 
                405                 410                 415     


Leu Lys Lys Ser Tyr Glu Ala Ala Leu Leu Pro Leu Tyr Met Glu Gly 
            420                 425                 430         


Gly Phe Val Glu Val Ile His Asp Lys Lys Gln Tyr Pro Ile Ser Glu 
        435                 440                 445             


Leu Cys Lys Gln Phe Arg Leu Pro Phe Asn Val Lys Val Ser Val Arg 
    450                 455                 460                 


Asp Leu Ser Ile Glu Glu Asp Val Leu Ala Ala Thr Pro Gly Leu Gln 
465                 470                 475                 480 


Leu Glu Glu Asp Ile Thr Asp Ser Tyr Leu Leu Ile Ser Asp Phe Ala 
                485                 490                 495     


Asn Pro Thr Glu Cys Trp Glu Ile Pro Val Gly Arg Leu Asn Met Thr 
            500                 505                 510         


Val Gln Leu Val Ser Asn Phe Ser Arg Asp Ala Glu Pro Phe Leu Val 
        515                 520                 525             


Arg Thr Leu Val Glu Glu Ile Thr Glu Glu Gln Tyr Tyr Met Met Arg 
    530                 535                 540                 


Arg Tyr Glu Ser Ser Ala Ser His Pro Pro Pro Arg Pro Pro Lys His 
545                 550                 555                 560 


Pro Ser Val Glu Glu Thr Lys Leu Thr Leu Leu Thr Leu Ala Glu Glu 
                565                 570                 575     


Arg Thr Val Asp Leu Pro Lys Ser Pro Lys Arg His His Val Asp Ile 
            580                 585                 590         


Thr Lys Lys Leu His Pro Asn Gln Ala Gly Leu Asp Ser Lys Val Leu 
        595                 600                 605             


Ile Gly Ser Gln Asn Asp Leu Val Asp Glu Glu Lys Glu Arg Ser Asn 
    610                 615                 620                 


Arg Gly Ala Thr Ala Val Ala Glu Thr Phe Lys Asn Glu Lys His Gln 
625                 630                 635                 640 


Lys Gly Leu Ser Ala Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly 
                645                 650                 655     


Ser Gly Gly Gly Ser Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu 
            660                 665                 670         


Lys 
    


<210>  5
<211>  2022
<212>  DNA
<213>  Artificial

<220>
<223>  Full length Themis cDNA + strep tag

<400>  5
atggcattat cactggaaga attcgtccac tcccttgacc tcaggaccct acccagggtt       60

ctagaaatcc aggcaggcat ctatcttgaa ggctctattt atgaaatgtt tggaaatgaa      120

tgctgttttt caacaggaga agtgattaaa attactggcc tcaaagttaa gaagatcata      180

gctgaaattt gtgagcagat tgaaggttgt gagtctctac agccatttga actgcctatg      240

aattttccag gtctttttaa gattgtggct gataaaactc cataccttac tatggaagaa      300

atcacaagga ccattcatat tggaccaagt agactagggc atccttgctt ctatcatcag      360

aaggatataa aactagagaa cctcatcata aagcagggtg agcaaatcat gctcaactca      420

gttgaagaga ttgatggaga aataatggtg agctgtgcag tagcaaggaa tcatcaaact      480

cactcattta atttgccttt gtcacaagaa ggagaattct acgagtgtga agatgaacgt      540

atttacactc taaaggagat tgttgaatgg aagattccta agaacagaac aagaactgta      600

aaccttacag atttttcaaa taagtgggac tcaacgaatc catttcctaa agacttttat      660

ggtaccctga ttctcaagcc tgtttatgaa attcaaggtg tgatgaaatt tcgaaaagat      720

ataatccgca tcctccccag tctagatgtc gaagtcaaag acatcactga ttcttacgat      780

gctaactggt ttcttcagct gttatcaaca gaagatcttt ttgaaatgac tagtaaagag      840

ttccccatag tgactgaagt catagaagca cctgaaggaa accacctgcc ccaaagcatt      900

ttacagcctg ggaaaaccat tgtgatccac aaaaagtacc aggcatcaag aatcttagct      960

tcagaaatta gaagcaattt tcctaaaaga cacttcttga tccccactag ctataaaggc     1020

aagttcaagc ggcgaccgag ggagttccca acggcctatg acctagagat cgctaagagt     1080

gaaaaggagc ctcttcacgt ggtggccacc aaagcgtttc attcccctca tgacaagctg     1140

tcatccgtat ctgttgggga ccagtttctg gtgcatcagt cagagacgac tgaagtcctc     1200

tgtgagggaa taaaaaaagt ggtgaatgtt ctggcctgtg aaaaaatcct caaaaagtcc     1260

tatgaggctg cgctgctccc tttgtacatg gaaggaggtt ttgtagaggt gattcatgat     1320

aagaaacagt acccgatttc tgagctctgt aaacagttcc gtttgccctt caatgtgaag     1380

gtgtctgtca gggatctttc cattgaagag gacgtgttgg ctgccacacc aggactgcag     1440

ttggaggagg acattacaga ctcttaccta ctcataagtg actttgccaa ccccacggag     1500

tgctgggaaa ttcctgtggg ccgcttgaat atgactgttc agttagttag taatttctct     1560

agggatgcag aaccatttct agtcaggact ctggtagaag agatcactga agagcaatat     1620

tacatgatgc ggagatatga aagctcagcc tcacatcccc cacctcgccc tccgaaacac     1680

ccctcagtag aggaaacaaa gttaaccctg ctaaccttag cagaagaaag gacggtagac     1740

ctgcccaagt ctcccaagcg tcatcacgta gacataacca agaaacttca cccaaatcaa     1800

gctggcctgg attcaaaagt actgattggt agtcagaatg atttggtgga tgaagagaaa     1860

gaaaggagca accgtggggc cacagcagta gcagaaacat tcaaaaatga aaaacatcaa     1920

aaaggtctca gcgcttggag ccacccgcag ttcgagaaag gtggaggttc cggaggtgga     1980

tcgggaggtg gatcgtggag ccacccgcag ttcgaaaaat aa                        2022


<210>  6
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  6

Val Glu Glu Ile Thr Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu 
1               5                   10                  15      


Ser Ser Ala Ser His Pro Pro Pro Arg Pro Pro Lys His 
            20                  25                  


<210>  7
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  7

Ile Thr Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala 
1               5                   10                  15      


Ser His Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val 
            20                  25                  


<210>  8
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  8

Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His Pro 
1               5                   10                  15      


Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu Thr 
            20                  25                  


<210>  9
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  9

Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His Pro Pro Pro Arg 
1               5                   10                  15      


Pro Pro Lys His Pro Ser Val Glu Glu Thr Lys Leu Thr 
            20                  25                  


<210>  10
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  10

Arg Arg Tyr Glu Ser Ser Ala Ser His Pro Pro Pro Arg Pro Pro Lys 
1               5                   10                  15      


His Pro Ser Val Glu Glu Thr Lys Leu Thr Leu Leu Thr 
            20                  25                  


<210>  11
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  11

Glu Ser Ser Ala Ser His Pro Pro Pro Arg Pro Pro Lys His Pro Ser 
1               5                   10                  15      


Val Glu Glu Thr Lys Leu Thr Leu Leu Thr Leu Ala Glu 
            20                  25                  


<210>  12
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  12

Ala Ser His Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
1               5                   10                  15      


Thr Lys Leu Thr Leu Leu Thr Leu Ala Glu Glu Arg Thr 
            20                  25                  


<210>  13
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  13

Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu Thr Lys Leu 
1               5                   10                  15      


Thr Leu Leu Thr Leu Ala Glu Glu Arg Thr Val Asp Leu 
            20                  25                  


<210>  14
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  14

Arg Pro Pro Lys His Pro Ser Val Glu Glu Thr Lys Leu Thr Leu Leu 
1               5                   10                  15      


Thr Leu Ala Glu Glu Arg Thr Val Asp Leu Pro Lys Ser 
            20                  25                  


<210>  15
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  15

Lys His Pro Ser Val Glu Glu Thr Lys Leu Thr Leu Leu Thr Leu Ala 
1               5                   10                  15      


Glu Glu Arg Thr Val Asp Leu Pro Lys Ser Pro Lys Arg 
            20                  25                  


<210>  16
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  16

Ser Val Glu Glu Thr Lys Leu Thr Leu Leu Thr Leu Ala Glu Glu Arg 
1               5                   10                  15      


Thr Val Asp Leu Pro Lys Ser Pro Lys Arg His His Val 
            20                  25                  


<210>  17
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  17

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  18
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  18

Ala Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  19
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  19

Glu Ala Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  20
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  20

Glu Glu Ala Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  21
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  21

Glu Glu Gln Ala Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  22
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  22

Glu Glu Gln Tyr Ala Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  23
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  23

Glu Glu Gln Tyr Tyr Ala Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  24
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  24

Glu Glu Gln Tyr Tyr Met Ala Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  25
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  25

Glu Glu Gln Tyr Tyr Met Met Ala Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  26
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  26

Glu Glu Gln Tyr Tyr Met Met Arg Ala Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  27
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  27

Glu Glu Gln Tyr Tyr Met Met Arg Arg Ala Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  28
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  28

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Ala Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  29
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  29

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ala Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  30
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  30

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ala Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  31
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  31

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Gly Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  32
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  32

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ala His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  33
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  33

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser Ala 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  34
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  34

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Ala Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  35
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  35

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Ala Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  36
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  36

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Ala Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  37
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  37

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Ala Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  38
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  38

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Ala Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  39
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  39

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Ala Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  40
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  40

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Ala His Pro Ser Val Glu Glu 
            20                  25                  


<210>  41
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  41

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys Ala Pro Ser Val Glu Glu 
            20                  25                  


<210>  42
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  42

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Ala Ser Val Glu Glu 
            20                  25                  


<210>  43
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  43

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ala Val Glu Glu 
            20                  25                  


<210>  44
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  44

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Ala Glu Glu 
            20                  25                  


<210>  45
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  45

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Ala Glu 
            20                  25                  


<210>  46
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  46

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Ala 
            20                  25                  


<210>  47
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  47

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  48
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  48

Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His Pro Pro 
1               5                   10                  15      


Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25          


<210>  49
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  49

Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His Pro Pro Pro Arg 
1               5                   10                  15      


Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25  


<210>  50
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  50

Met Arg Arg Tyr Glu Ser Ser Ala Ser His Pro Pro Pro Arg Pro Pro 
1               5                   10                  15      


Lys His Pro Ser Val Glu Glu 
            20              


<210>  51
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  51

Arg Tyr Glu Ser Ser Ala Ser His Pro Pro Pro Arg Pro Pro Lys His 
1               5                   10                  15      


Pro Ser Val Glu Glu 
            20      


<210>  52
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  52

Glu Ser Ser Ala Ser His Pro Pro Pro Arg Pro Pro Lys His Pro Ser 
1               5                   10                  15      


Val Glu Glu 
            


<210>  53
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  53

Ser Ala Ser His Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu 
1               5                   10                  15      


Glu 
    


<210>  54
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  54

Ser His Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
1               5                   10                  15  


<210>  55
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  55

Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
1               5                   10              


<210>  56
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  56

Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
1               5                   10      


<210>  57
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  57

Pro Pro Lys His Pro Ser Val Glu Glu 
1               5                   


<210>  58
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  58

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  59
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  59

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val 
            20                  25          


<210>  60
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  60

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro 
            20                  25  


<210>  61
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  61

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys 
            20              


<210>  62
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  62

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro 
            20      


<210>  63
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  63

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  64
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  64

Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His Pro Pro 
1               5                   10                  15      


Pro Arg Pro Pro Lys His Pro Ser Val 
            20                  25  


<210>  65
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  65

Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His Pro Pro Pro Arg 
1               5                   10                  15      


Pro Pro Lys His Pro 
            20      


<210>  66
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  66

Met Arg Arg Tyr Glu Ser Ser Ala Ser His Pro Pro Pro Arg Pro Pro 
1               5                   10                  15      


Lys 
    


<210>  67
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  67

Arg Tyr Glu Ser Ser Ala Ser His Pro Pro Pro Arg Pro 
1               5                   10              


<210>  68
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  68

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  69
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  69

Ser His Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val 
1               5                   10              


<210>  70
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  70

Pro Pro Pro Arg Pro Pro Lys His Pro 
1               5                   


<210>  71
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  71

Pro Arg Pro Pro Lys 
1               5   


<210>  72
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  72

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  73
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  PHOSPHORYLATION

<400>  73

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  74
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  PHOSPHORYLATION

<400>  74

Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  75
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  75

Glu Glu Gln Phe Phe Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


<210>  76
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide fragment

<400>  76

Glu Glu Gln Ala Ala Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His 
1               5                   10                  15      


Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val Glu Glu 
            20                  25                  


