                         SEQUENCE LISTING

<110>  Alacris Theranostics GmbH
 
<120>  Method of nucleic acid amplification

<130>  B106-0021WO1

<150>  EP 12 17 9283.2
<151>  2012-08-03

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  1719
<212>  DNA
<213>  Bacillus bacteriophage phi29 polymerase

<400>  1
atgccgagaa agatgtatag ttgtgacttt gagacaacta ctaaagtgga agactgtagg       60

gtatgggcgt atggttatat gaatatagaa gatcacagtg agtacaaaat aggtaatagc      120

ctggatgagt ttatggcgtg ggtgttgaag gtacaagctg atctatattt ccataacctc      180

aaatttgacg gagcttttat cattaactgg ttggaacgta atggttttaa gtggtcggct      240

gacggattgc caaacacata taatacgatc atatctcgca tgggacaatg gtacatgatt      300

gatatatgtt taggctacaa agggaaacgt aagatacata cagtgatata tgacagctta      360

aagaaactac cgtttcctgt taagaagata gctaaagact ttaaactaac tgttcttaaa      420

ggtgatattg attaccacaa agaaagacca gtcggctata agataacacc cgaagaatac      480

gcctatatta aaaacgatat tcagattatt gcggaagctc tgttaattca gtttaagcaa      540

ggtttagacc ggatgacagc aggcagtgac agtctaaaag gtttcaagga tattataacc      600

actaagaaat tcaaaaaggt gtttcctaca ttgagtcttg gactcgataa ggaagtgaga      660

tacgcctata gaggtggttt tacatggtta aatgataggt tcaaagaaaa agaaatcgga      720

gaaggcatgg tcttcgatgt taatagtcta tatcctgcac agatgtatag ccgtctcctt      780

ccatatggtg aacctatagt attcgagggt aaatacgttt gggacgaaga ttacccacta      840

cacatacagc atatcagatg tgagttcgaa ttgaaagagg gctatatacc cactatacag      900

ataaaaagaa gtaggtttta taaaggtaat gagtacctaa aaagtagcgg cggggagata      960

gccgacctct ggttgtcaaa tgtagaccta gaattaatga aagaacacta cgatttatat     1020

aacgttgaat atatcagcgg cttaaaattt aaagcaacta caggtttgtt taaagatttt     1080

atagataaat ggacgtacat caagacgaca tcagaaggag cgatcaagca actagcaaaa     1140

ctgatgttaa acagtctata cggtaaattc gctagtaacc ctgatgttac agggaaagtc     1200

ccttatttaa aagagaatgg ggcgctaggt ttcagacttg gagaagagga aacaaaagac     1260

cctgtttata cacctatggg cgttttcatc actgcatggg ctagatacac gacaattaca     1320

gcggcacagg cttgttatga tcggataata tactgtgata ctgacagcat acatttaacg     1380

ggtacagaga tacctgatgt aataaaagat atagttgacc ctaagaaatt gggatactgg     1440

gcacatgaaa gtacattcaa aagagctaaa tatctgagac agaagaccta tatacaagac     1500

atctatatga aagaagtaga tggtaagtta gtagaaggta gtccagatga ttacactgat     1560

ataaaattta gtgttaaatg tgcgggaatg actgacaaga ttaagaaaga ggttacgttt     1620

gagaatttca aagtcggatt cagtcggaaa atgaagccta agcctgtgca agtgccgggc     1680

ggggtggttc tggttgatga cacattcaca atcaaataa                            1719


<210>  2
<211>  572
<212>  PRT
<213>  Bacillus bacteriophage phi29 DNA polymerase

<400>  2

Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr Thr Lys Val 
1               5                   10                  15      


Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile Glu Asp His 
            20                  25                  30          


Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Ala Trp Val 
        35                  40                  45              


Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 
            260                 265                 270         


Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 
        275                 280                 285             


Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 
    290                 295                 300                 


Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 
305                 310                 315                 320 


Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 
                325                 330                 335     


Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 
            340                 345                 350         


Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 
    450                 455                 460                 


Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys Leu Val Glu 
            500                 505                 510         


Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 
                565                 570         


<210>  3
<211>  1563
<212>  DNA
<213>  Halomonas phage phiHAP-1 protelomerase

<400>  3
atgagcggtg agtcacgtag aaaggtcgat ttagcggaat tgatagagtg gttgctcagc       60

gagatcaaag agatcgacgc cgatgatgag atgccacgta aagagaaaac caagcgcatg      120

gcgcggctgg cacgtagctt caaaacgcgc ctgcatgatg acaagcgccg caaggattct      180

gagcggatcg cggtcacgac ctttcgccgc tacatgacag aagcgcgcaa ggcggtgact      240

gcgcagaact ggcgccatca cagcttcgac cagcagatcg agcggctggc cagccgctac      300

ccggcttatg ccagcaagct ggaagcgctc ggcaagctga ccgatatcag cgccattcgt      360

atggcccacc gcgagctgct cgaccagatc cgcaacgatg acgacgctta tgaggacatc      420

cgggcgatga agctggacca tgaaatcatg cgccacctga cgttgagctc tgcacagaaa      480

agcacgctgg ctgaagaggc cagcgagacg ctggaagagc gcgcggtgaa cacggtcgag      540

atcaactacc actggttgat ggagacggtt tacgagctgc tgagtaaccg ggagagaatg      600

gtcgatgggg agtatcgcgg ctttttcagt tacctagcgc ttgggctggc gctggccacc      660

gggcgtcgct cgatcgaggt gctgaagacc ggacggatca cgaaggtggg cgagtatgag      720

ctggagttca gcggccaggc gaaaaagcgc ggcggcgtcg actatagcga ggcttaccac      780

atttataccc tggtgaaagc tgacctggtg atcgaagcgt gggatgagct tcgctcgctg      840

ccggaagctg ctgagctgca gggcatggac aacagcgatg tgaaccgccg cacggcgaag      900

acgctcaaca cgctcactaa gcggatcttt aacaacgatg agcgcgtttt caaggacagc      960

cgggcgatct gggcgcggct ggtgtttgag ctgcacttct cgcgcgacaa gcgctggaag     1020

aaagtcaccg aggacgtgtt ctggcgtgag atgctggggc atgaggacat ggatacacag     1080

cgcagctacc gcgcctttaa aatcgactac gacgagccgg atcaagccga ccaggaagat     1140

tacgaacacg ctagccgcct cgccgcgctg caggcgctgg acggccatga gcagcttgag     1200

agcagcgacg cccaggcgcg tgtgcatgcc tgggtgaaag cgcagatcga gcaggagcct     1260

gacgcgaaaa ttacgcagtc tctgatcagc cgggagctgg gcgtttatcg ccctgccata     1320

aaagcgtacc tggagctggc gcgagaggcg ctcgacgcgc cgaacgtcga tctggacaag     1380

gtcgcggcgg cagtgccgaa ggaagtagcc gaggcgaagc cccggctgaa cgcccaccca     1440

caaggggatg gcaggtgggt cggggtggct tcaatcaacg gggtggaagt tgcacgggtg     1500

ggcaaccagg caggccggat cgaagcgatg aaagcggcct ataaagcggc gggtgggcgc     1560

tga                                                                   1563


<210>  4
<211>  520
<212>  PRT
<213>  Halomonas phage phiHAP-1 protelomerase

<400>  4

Met Ser Gly Glu Ser Arg Arg Lys Val Asp Leu Ala Glu Leu Ile Glu 
1               5                   10                  15      


Trp Leu Leu Ser Glu Ile Lys Glu Ile Asp Ala Asp Asp Glu Met Pro 
            20                  25                  30          


Arg Lys Glu Lys Thr Lys Arg Met Ala Arg Leu Ala Arg Ser Phe Lys 
        35                  40                  45              


Thr Arg Leu His Asp Asp Lys Arg Arg Lys Asp Ser Glu Arg Ile Ala 
    50                  55                  60                  


Val Thr Thr Phe Arg Arg Tyr Met Thr Glu Ala Arg Lys Ala Val Thr 
65                  70                  75                  80  


Ala Gln Asn Trp Arg His His Ser Phe Asp Gln Gln Ile Glu Arg Leu 
                85                  90                  95      


Ala Ser Arg Tyr Pro Ala Tyr Ala Ser Lys Leu Glu Ala Leu Gly Lys 
            100                 105                 110         


Leu Thr Asp Ile Ser Ala Ile Arg Met Ala His Arg Glu Leu Leu Asp 
        115                 120                 125             


Gln Ile Arg Asn Asp Asp Asp Ala Tyr Glu Asp Ile Arg Ala Met Lys 
    130                 135                 140                 


Leu Asp His Glu Ile Met Arg His Leu Thr Leu Ser Ser Ala Gln Lys 
145                 150                 155                 160 


Ser Thr Leu Ala Glu Glu Ala Ser Glu Thr Leu Glu Glu Arg Ala Val 
                165                 170                 175     


Asn Thr Val Glu Ile Asn Tyr His Trp Leu Met Glu Thr Val Tyr Glu 
            180                 185                 190         


Leu Leu Ser Asn Arg Glu Arg Met Val Asp Gly Glu Tyr Arg Gly Phe 
        195                 200                 205             


Phe Ser Tyr Leu Ala Leu Gly Leu Ala Leu Ala Thr Gly Arg Arg Ser 
    210                 215                 220                 


Ile Glu Val Leu Lys Thr Gly Arg Ile Thr Lys Val Gly Glu Tyr Glu 
225                 230                 235                 240 


Leu Glu Phe Ser Gly Gln Ala Lys Lys Arg Gly Gly Val Asp Tyr Ser 
                245                 250                 255     


Glu Ala Tyr His Ile Tyr Thr Leu Val Lys Ala Asp Leu Val Ile Glu 
            260                 265                 270         


Ala Trp Asp Glu Leu Arg Ser Leu Pro Glu Ala Ala Glu Leu Gln Gly 
        275                 280                 285             


Met Asp Asn Ser Asp Val Asn Arg Arg Thr Ala Lys Thr Leu Asn Thr 
    290                 295                 300                 


Leu Thr Lys Arg Ile Phe Asn Asn Asp Glu Arg Val Phe Lys Asp Ser 
305                 310                 315                 320 


Arg Ala Ile Trp Ala Arg Leu Val Phe Glu Leu His Phe Ser Arg Asp 
                325                 330                 335     


Lys Arg Trp Lys Lys Val Thr Glu Asp Val Phe Trp Arg Glu Met Leu 
            340                 345                 350         


Gly His Glu Asp Met Asp Thr Gln Arg Ser Tyr Arg Ala Phe Lys Ile 
        355                 360                 365             


Asp Tyr Asp Glu Pro Asp Gln Ala Asp Gln Glu Asp Tyr Glu His Ala 
    370                 375                 380                 


Ser Arg Leu Ala Ala Leu Gln Ala Leu Asp Gly His Glu Gln Leu Glu 
385                 390                 395                 400 


Ser Ser Asp Ala Gln Ala Arg Val His Ala Trp Val Lys Ala Gln Ile 
                405                 410                 415     


Glu Gln Glu Pro Asp Ala Lys Ile Thr Gln Ser Leu Ile Ser Arg Glu 
            420                 425                 430         


Leu Gly Val Tyr Arg Pro Ala Ile Lys Ala Tyr Leu Glu Leu Ala Arg 
        435                 440                 445             


Glu Ala Leu Asp Ala Pro Asn Val Asp Leu Asp Lys Val Ala Ala Ala 
    450                 455                 460                 


Val Pro Lys Glu Val Ala Glu Ala Lys Pro Arg Leu Asn Ala His Pro 
465                 470                 475                 480 


Gln Gly Asp Gly Arg Trp Val Gly Val Ala Ser Ile Asn Gly Val Glu 
                485                 490                 495     


Val Ala Arg Val Gly Asn Gln Ala Gly Arg Ile Glu Ala Met Lys Ala 
            500                 505                 510         


Ala Tyr Lys Ala Ala Gly Gly Arg 
        515                 520 


<210>  5
<211>  1887
<212>  DNA
<213>  Yersinia phage PY54 protelomerase

<400>  5
atgggttact tattattttt atttggaggc gttatgaaaa tccattttcg cgatttagtt       60

agtggtttag ttaaagagat cgatgaaata gaaaaatcag accgggcgca gggtgacaaa      120

actcggcgtt atcagggcgc ggccagaaag ttcaaaaatg ccgtgtttat ggataaacgg      180

aaatatcgcg gtaacggtat gaagaataga atatcgttaa caacatttaa taaatattta      240

agtcgagcac gttctcggtt tgaagaaagg cttcaccata gttttcctca atctatagca      300

actatctcaa ataaatatcc tgcattcagc gaaataataa aagatctgga taatagaccc      360

gctcatgaag ttagaataaa acttaaagaa ttaataactc atcttgaatc cggtgttaat      420

ttattagaaa aaataggtag cttagggaaa ataaaaccat ctacagctaa aaaaatagtt      480

agcttaaaaa aaatgtaccc atcatgggct aatgatctag atactttaat tagtactgaa      540

gatgctacag aattacaaca aaagttagag caagggaccg acctacttaa cgcattacat      600

tctctaaaag taaaccatga agttatgtat gcattaacga tgcagccttc tgacagagct      660

gcattaaaag ctaggcatga cgctgccctt cactttaaaa agcgtaacat cgtacctatc      720

gattatcccg gctatatgca acgaatgacg gacatactac atcttccaga tatagctttt      780

gaagattcga tggcatcact tgccccttta gcatttgctc tagcagctgc tagcggtcgc      840

agacaaattg aaatactaat tactggtgag tttgacgcca aaaataaaag catcattaaa      900

ttttctggac aagcaaaaaa aagaatggcc gtttcaggtg gacattatga aatatacagt      960

ctaattgact cagagctatt cattcaacgg ttagagtttt tacgttctca tagctcaata     1020

cttcgattac aaaatttgga aatagcacat gatgaacatc gtactgaact atctgttatt     1080

aacggttttg tagccaaacc tttaaatgat gcagcaaaac agttctttgt cgatgacaga     1140

agagtattta aagatacccg tgcaatttac gctcgcatag catatgaaaa atggtttaga     1200

acagatcctc gctgggcgaa gtgcgacgaa gatgttttct tctctgaatt attaggccat     1260

gacgacccag atactcagct ggcatataaa caattcaagc tggtaaattt caatccaaaa     1320

tggacaccta atatatcaga tgaaaaccct cggttagctg cacttcaaga gcttgacaat     1380

gatatgcccg gcctagcacg tggcgatgcg gcagttcgca tacatgagtg ggttaaagag     1440

caactggcgc agaaccctgc ggcaaaaata actgcatacc aaatcaagaa aaatttaaat     1500

tgtcgaaatg acttggccag ccgatacatg gcatggtgtg ctgacgcgct aggggttgtt     1560

attggtgatg atggacaggc aaggccagaa gaactcccac catcgctcgt gcttgatatt     1620

aacgctgatg acactgacgc tgaagaagat gaaatagagg aagactttac tgatgaggaa     1680

atagacgaca ccgaattcga cgtatcagat aacgccagtg atgaagataa gcccgaagat     1740

aaacctcgct ttgcagcacc aattcgtaga agtgaggact cttggctgat taaatttgaa     1800

tttgctggca agcaatatag ctgggagggt aatgccgaaa gtgttatcga tgcgatgaaa     1860

caagcatgga ctgaaaatat ggagtaa                                         1887


<210>  6
<211>  628
<212>  PRT
<213>  Yersinia phage PY54

<400>  6

Met Gly Tyr Leu Leu Phe Leu Phe Gly Gly Val Met Lys Ile His Phe 
1               5                   10                  15      


Arg Asp Leu Val Ser Gly Leu Val Lys Glu Ile Asp Glu Ile Glu Lys 
            20                  25                  30          


Ser Asp Arg Ala Gln Gly Asp Lys Thr Arg Arg Tyr Gln Gly Ala Ala 
        35                  40                  45              


Arg Lys Phe Lys Asn Ala Val Phe Met Asp Lys Arg Lys Tyr Arg Gly 
    50                  55                  60                  


Asn Gly Met Lys Asn Arg Ile Ser Leu Thr Thr Phe Asn Lys Tyr Leu 
65                  70                  75                  80  


Ser Arg Ala Arg Ser Arg Phe Glu Glu Arg Leu His His Ser Phe Pro 
                85                  90                  95      


Gln Ser Ile Ala Thr Ile Ser Asn Lys Tyr Pro Ala Phe Ser Glu Ile 
            100                 105                 110         


Ile Lys Asp Leu Asp Asn Arg Pro Ala His Glu Val Arg Ile Lys Leu 
        115                 120                 125             


Lys Glu Leu Ile Thr His Leu Glu Ser Gly Val Asn Leu Leu Glu Lys 
    130                 135                 140                 


Ile Gly Ser Leu Gly Lys Ile Lys Pro Ser Thr Ala Lys Lys Ile Val 
145                 150                 155                 160 


Ser Leu Lys Lys Met Tyr Pro Ser Trp Ala Asn Asp Leu Asp Thr Leu 
                165                 170                 175     


Ile Ser Thr Glu Asp Ala Thr Glu Leu Gln Gln Lys Leu Glu Gln Gly 
            180                 185                 190         


Thr Asp Leu Leu Asn Ala Leu His Ser Leu Lys Val Asn His Glu Val 
        195                 200                 205             


Met Tyr Ala Leu Thr Met Gln Pro Ser Asp Arg Ala Ala Leu Lys Ala 
    210                 215                 220                 


Arg His Asp Ala Ala Leu His Phe Lys Lys Arg Asn Ile Val Pro Ile 
225                 230                 235                 240 


Asp Tyr Pro Gly Tyr Met Gln Arg Met Thr Asp Ile Leu His Leu Pro 
                245                 250                 255     


Asp Ile Ala Phe Glu Asp Ser Met Ala Ser Leu Ala Pro Leu Ala Phe 
            260                 265                 270         


Ala Leu Ala Ala Ala Ser Gly Arg Arg Gln Ile Glu Ile Leu Ile Thr 
        275                 280                 285             


Gly Glu Phe Asp Ala Lys Asn Lys Ser Ile Ile Lys Phe Ser Gly Gln 
    290                 295                 300                 


Ala Lys Lys Arg Met Ala Val Ser Gly Gly His Tyr Glu Ile Tyr Ser 
305                 310                 315                 320 


Leu Ile Asp Ser Glu Leu Phe Ile Gln Arg Leu Glu Phe Leu Arg Ser 
                325                 330                 335     


His Ser Ser Ile Leu Arg Leu Gln Asn Leu Glu Ile Ala His Asp Glu 
            340                 345                 350         


His Arg Thr Glu Leu Ser Val Ile Asn Gly Phe Val Ala Lys Pro Leu 
        355                 360                 365             


Asn Asp Ala Ala Lys Gln Phe Phe Val Asp Asp Arg Arg Val Phe Lys 
    370                 375                 380                 


Asp Thr Arg Ala Ile Tyr Ala Arg Ile Ala Tyr Glu Lys Trp Phe Arg 
385                 390                 395                 400 


Thr Asp Pro Arg Trp Ala Lys Cys Asp Glu Asp Val Phe Phe Ser Glu 
                405                 410                 415     


Leu Leu Gly His Asp Asp Pro Asp Thr Gln Leu Ala Tyr Lys Gln Phe 
            420                 425                 430         


Lys Leu Val Asn Phe Asn Pro Lys Trp Thr Pro Asn Ile Ser Asp Glu 
        435                 440                 445             


Asn Pro Arg Leu Ala Ala Leu Gln Glu Leu Asp Asn Asp Met Pro Gly 
    450                 455                 460                 


Leu Ala Arg Gly Asp Ala Ala Val Arg Ile His Glu Trp Val Lys Glu 
465                 470                 475                 480 


Gln Leu Ala Gln Asn Pro Ala Ala Lys Ile Thr Ala Tyr Gln Ile Lys 
                485                 490                 495     


Lys Asn Leu Asn Cys Arg Asn Asp Leu Ala Ser Arg Tyr Met Ala Trp 
            500                 505                 510         


Cys Ala Asp Ala Leu Gly Val Val Ile Gly Asp Asp Gly Gln Ala Arg 
        515                 520                 525             


Pro Glu Glu Leu Pro Pro Ser Leu Val Leu Asp Ile Asn Ala Asp Asp 
    530                 535                 540                 


Thr Asp Ala Glu Glu Asp Glu Ile Glu Glu Asp Phe Thr Asp Glu Glu 
545                 550                 555                 560 


Ile Asp Asp Thr Glu Phe Asp Val Ser Asp Asn Ala Ser Asp Glu Asp 
                565                 570                 575     


Lys Pro Glu Asp Lys Pro Arg Phe Ala Ala Pro Ile Arg Arg Ser Glu 
            580                 585                 590         


Asp Ser Trp Leu Ile Lys Phe Glu Phe Ala Gly Lys Gln Tyr Ser Trp 
        595                 600                 605             


Glu Gly Asn Ala Glu Ser Val Ile Asp Ala Met Lys Gln Ala Trp Thr 
    610                 615                 620                 


Glu Asn Met Glu 
625             


<210>  7
<211>  1923
<212>  DNA
<213>  Klebsiella phage phiK02 protelomerase

<400>  7
atgcgtaagg tgaaaattgg tgagctaatc aattcgcttg tgagcgaggt cgaggcaatc       60

gatgcctctg atcgtccgca aggcgataaa acgaagaaaa ttaaagccgc agcattaaaa      120

tataagaatg cattatttaa tgacaaaaga aagtttcgcg gtaaaggttt agaaaaaaga      180

atttctgcca acacgttcaa ctcgtatatg agtcgggcaa ggaaaagatt tgatgataga      240

ttgcatcata actttgaaaa gaatgtaatt aaactatcag aaaaatatcc tttatatagt      300

gaagaattat cttcgtggct ttctatgcct gcggcatcaa ttagacagca tatgtcaaga      360

ttgcaagcca agctaaaaga gataatgcca ttggcagaag acttatccaa tataaagatt      420

ggtacaaaaa atagcgaagc aaaaataaat aaactcgcta ataaatatcc tgaatggcaa      480

ttcgctatta gtgatttaaa tagcgaagat tggaaggata aaagagatta tctttataaa      540

ctattccaac aaggttcttc gctcctggaa gacttgaata acctgaaagt aaaccatgag      600

gttctctatc atctgcagct tagttctgcc gagcgaacct ctatccagca gcgctgggcc      660

aacgtcctca gcgagaaaaa gcgcaacgtt gtcgtgattg actatccgcg ctatatgcag      720

gccatctacg atataatcaa caagcctata gtttcgttcg atttgactac tcgtcgtggt      780

atggccccgc tggcgttcgc ccttgccgcg ctatctggtc gccgaatgat tgaaatcatg      840

ctccagggtg aattttccgt cgcaggtaaa tatacagtaa cattcctggg gcaagctaaa      900

aaacgctcgg aagataaagg tatatcaagg aaaatatata ccttatgcga cgctacttta      960

tttgttagtt tggtaaatga acttcgctca tgccccgctg ctgcggattt tgatgaagta     1020

ataaaaggat atggcgaaaa tgacactcgc tcagaaaatg ggcgtattaa tgcaattctc     1080

gctacagctt ttaatccgtg ggtaaaaact ttcttaggcg atgaccgccg cgtttataaa     1140

gatagccgcg ctatttacgc ccgtattgcc tatgaaatgt tcttccgcgt tgaccctcgg     1200

tggaagaatg ttgatgagga tgtattcttc atggagattc tcggccatga cgatgaaaac     1260

acccaactgc actataagca gtttaaattg gctaacttct ccagaacatg gcgaccaaat     1320

gtcggcgagg agaatgcccg cctagcggcg ctgcaaaagc tggatagcat gatgccagat     1380

tttgccaggg gcgacgccgg ggttcgtatt catgagaccg tgaagcagct ggtggagcag     1440

gacccatcga taaaaatcac aaacagcacc ctgcgaccgt ttaacttcag taccaggctg     1500

attcctcgct acctggagtt tgccgccgat gcattgggcc agttcgtcgg tgaaaatggg     1560

caatggcaac tgaaggatga ggcgcctgca atagtcctgc ctgatgagga aattcttgag     1620

cctatggacg acgtcgatct cgatgacgaa aaccatgatg atgaaacgct ggatgacgat     1680

gagatcgaag tggacgaaag cgaaggagag gaactggagg aagcgggcga cgctgaagag     1740

gccgaggtgg ctgaacagga agagaagcac cctggcaagc caaactttaa agcgccgagg     1800

gataatggcg atggtaccta catggtggaa tttgaattcg gtggccgtca ttacgcctgg     1860

tccggtgccg ccggtaatcg ggtagaggca atgcaatctg cctggagtgc ctacttcaag     1920

tga                                                                   1923


<210>  8
<211>  640
<212>  PRT
<213>  Klebsiella phage phiK02 protelomerase

<400>  8

Met Arg Lys Val Lys Ile Gly Glu Leu Ile Asn Ser Leu Val Ser Glu 
1               5                   10                  15      


Val Glu Ala Ile Asp Ala Ser Asp Arg Pro Gln Gly Asp Lys Thr Lys 
            20                  25                  30          


Lys Ile Lys Ala Ala Ala Leu Lys Tyr Lys Asn Ala Leu Phe Asn Asp 
        35                  40                  45              


Lys Arg Lys Phe Arg Gly Lys Gly Leu Glu Lys Arg Ile Ser Ala Asn 
    50                  55                  60                  


Thr Phe Asn Ser Tyr Met Ser Arg Ala Arg Lys Arg Phe Asp Asp Arg 
65                  70                  75                  80  


Leu His His Asn Phe Glu Lys Asn Val Ile Lys Leu Ser Glu Lys Tyr 
                85                  90                  95      


Pro Leu Tyr Ser Glu Glu Leu Ser Ser Trp Leu Ser Met Pro Ala Ala 
            100                 105                 110         


Ser Ile Arg Gln His Met Ser Arg Leu Gln Ala Lys Leu Lys Glu Ile 
        115                 120                 125             


Met Pro Leu Ala Glu Asp Leu Ser Asn Ile Lys Ile Gly Thr Lys Asn 
    130                 135                 140                 


Ser Glu Ala Lys Ile Asn Lys Leu Ala Asn Lys Tyr Pro Glu Trp Gln 
145                 150                 155                 160 


Phe Ala Ile Ser Asp Leu Asn Ser Glu Asp Trp Lys Asp Lys Arg Asp 
                165                 170                 175     


Tyr Leu Tyr Lys Leu Phe Gln Gln Gly Ser Ser Leu Leu Glu Asp Leu 
            180                 185                 190         


Asn Asn Leu Lys Val Asn His Glu Val Leu Tyr His Leu Gln Leu Ser 
        195                 200                 205             


Ser Ala Glu Arg Thr Ser Ile Gln Gln Arg Trp Ala Asn Val Leu Ser 
    210                 215                 220                 


Glu Lys Lys Arg Asn Val Val Val Ile Asp Tyr Pro Arg Tyr Met Gln 
225                 230                 235                 240 


Ala Ile Tyr Asp Ile Ile Asn Lys Pro Ile Val Ser Phe Asp Leu Thr 
                245                 250                 255     


Thr Arg Arg Gly Met Ala Pro Leu Ala Phe Ala Leu Ala Ala Leu Ser 
            260                 265                 270         


Gly Arg Arg Met Ile Glu Ile Met Leu Gln Gly Glu Phe Ser Val Ala 
        275                 280                 285             


Gly Lys Tyr Thr Val Thr Phe Leu Gly Gln Ala Lys Lys Arg Ser Glu 
    290                 295                 300                 


Asp Lys Gly Ile Ser Arg Lys Ile Tyr Thr Leu Cys Asp Ala Thr Leu 
305                 310                 315                 320 


Phe Val Ser Leu Val Asn Glu Leu Arg Ser Cys Pro Ala Ala Ala Asp 
                325                 330                 335     


Phe Asp Glu Val Ile Lys Gly Tyr Gly Glu Asn Asp Thr Arg Ser Glu 
            340                 345                 350         


Asn Gly Arg Ile Asn Ala Ile Leu Ala Thr Ala Phe Asn Pro Trp Val 
        355                 360                 365             


Lys Thr Phe Leu Gly Asp Asp Arg Arg Val Tyr Lys Asp Ser Arg Ala 
    370                 375                 380                 


Ile Tyr Ala Arg Ile Ala Tyr Glu Met Phe Phe Arg Val Asp Pro Arg 
385                 390                 395                 400 


Trp Lys Asn Val Asp Glu Asp Val Phe Phe Met Glu Ile Leu Gly His 
                405                 410                 415     


Asp Asp Glu Asn Thr Gln Leu His Tyr Lys Gln Phe Lys Leu Ala Asn 
            420                 425                 430         


Phe Ser Arg Thr Trp Arg Pro Asn Val Gly Glu Glu Asn Ala Arg Leu 
        435                 440                 445             


Ala Ala Leu Gln Lys Leu Asp Ser Met Met Pro Asp Phe Ala Arg Gly 
    450                 455                 460                 


Asp Ala Gly Val Arg Ile His Glu Thr Val Lys Gln Leu Val Glu Gln 
465                 470                 475                 480 


Asp Pro Ser Ile Lys Ile Thr Asn Ser Thr Leu Arg Pro Phe Asn Phe 
                485                 490                 495     


Ser Thr Arg Leu Ile Pro Arg Tyr Leu Glu Phe Ala Ala Asp Ala Leu 
            500                 505                 510         


Gly Gln Phe Val Gly Glu Asn Gly Gln Trp Gln Leu Lys Asp Glu Ala 
        515                 520                 525             


Pro Ala Ile Val Leu Pro Asp Glu Glu Ile Leu Glu Pro Met Asp Asp 
    530                 535                 540                 


Val Asp Leu Asp Asp Glu Asn His Asp Asp Glu Thr Leu Asp Asp Asp 
545                 550                 555                 560 


Glu Ile Glu Val Asp Glu Ser Glu Gly Glu Glu Leu Glu Glu Ala Gly 
                565                 570                 575     


Asp Ala Glu Glu Ala Glu Val Ala Glu Gln Glu Glu Lys His Pro Gly 
            580                 585                 590         


Lys Pro Asn Phe Lys Ala Pro Arg Asp Asn Gly Asp Gly Thr Tyr Met 
        595                 600                 605             


Val Glu Phe Glu Phe Gly Gly Arg His Tyr Ala Trp Ser Gly Ala Ala 
    610                 615                 620                 


Gly Asn Arg Val Glu Ala Met Gln Ser Ala Trp Ser Ala Tyr Phe Lys 
625                 630                 635                 640 


<210>  9
<211>  1617
<212>  DNA
<213>  Vibrio phage VP882 protelomerase

<400>  9
atgagcggcg aaagtagaca aaaggtaaac ctcgaggagt taataaatga gctcgtcgag       60

gaggtgaaaa ccatcgatga caatgaggcg attactcggt ctgaaaaaac caagttgatc      120

accagggcgg cgactaaatt caagaccaag ctgcacgacg ataagcgccg gaaggatgcg      180

accagaatcg ctctgagcac ctatcgtaag tacatgacaa tggccagggc agcagttact      240

gagcagaact ggaaacacca cagtctcgag cagcagatag agcggctggc caaaaagcac      300

ccgcaatacg ctgagcagct ggtggccatc ggggccatgg ataacatcac cgagttgcgc      360

ctggcgcatc gcgacctcct gaagagcatc aaggacaacg atgaagcctt cgaggatatc      420

cgcagcatga agttagacca cgaggtaatg cgccatctga cgctacccag tgcgcaaaag      480

gcgagactgg cagaggaagc cgccgaggcg ttgaccgaga agaaaaccgc cacggtcgac      540

atcaactatc acgagctgat ggccggcgtg gtggagctgt tgaccaagaa gaccaagacg      600

gtcggcagcg acagcaccta cagcttcagc cggctggcgc ttggtattgg cctggctacc      660

ggtcgtcgtt ctatcgagat actgaagcag ggcgagttca aaaaggtgga tgagcagcgg      720

ctcgagttct ctggccaagc gaaaaagcgc ggcggtgccg actattcaga gacctatacc      780

atttacaccc tggtcgactc cgacctggta ctgatggcgc tgaagaacct gcgagagttg      840

ccagaagttc gcgcactgga tgagtacgac caactgggcg agattaagcg gaacgacgcc      900

atcaataaac gctgtgcaaa aacgctcaac caaaccgcca agcagttctt tggcagcgac      960

gagcgcgtgt tcaaagatag tcgtgccatc tgggcgcgtc tggcttatga gttgtttttt     1020

caacgtgatc cgcgctggaa aaagaaagac gaggacgttt tctggcagga gatgctgggc     1080

cacgaggaca tcgagactca gaaagcctat aagcaattca aggtcgacta cagcgaacct     1140

gagcagccgg tgcacaagcc tggcaaattt aagagcagag ctgaagccct cgcggcgctc     1200

gactcaaatg aggacattac cacccgctca tccatggcca agatccacga ctgggtgaaa     1260

gagcgtattg cggaagaccc cgaggcgaac atcacacagt cactcatcac ccgggaactg     1320

ggctcaggcc gtaaggtgat caaggactac ctcgacctgg ctgacgatgc ccttgctgtg     1380

gtgaatactc ctgtcgatga cgcagtcgtc gaggttccag ctgatgtgcc ggcagcagaa     1440

aaacagccga agaaagcgca gaagcccaga ctcgtggctc accaggttga tgatgagcac     1500

tgggaagcct gggcgctggt ggaaggcgag gaggtggcca gggtgaaaat caagggcacc     1560

cgcgttgagg caatgacagc cgcatgggag gccagccaaa aggcactcga tgactaa        1617


<210>  10
<211>  538
<212>  PRT
<213>  Vibrio phage VP882 protelomerase

<400>  10

Met Ser Gly Glu Ser Arg Gln Lys Val Asn Leu Glu Glu Leu Ile Asn 
1               5                   10                  15      


Glu Leu Val Glu Glu Val Lys Thr Ile Asp Asp Asn Glu Ala Ile Thr 
            20                  25                  30          


Arg Ser Glu Lys Thr Lys Leu Ile Thr Arg Ala Ala Thr Lys Phe Lys 
        35                  40                  45              


Thr Lys Leu His Asp Asp Lys Arg Arg Lys Asp Ala Thr Arg Ile Ala 
    50                  55                  60                  


Leu Ser Thr Tyr Arg Lys Tyr Met Thr Met Ala Arg Ala Ala Val Thr 
65                  70                  75                  80  


Glu Gln Asn Trp Lys His His Ser Leu Glu Gln Gln Ile Glu Arg Leu 
                85                  90                  95      


Ala Lys Lys His Pro Gln Tyr Ala Glu Gln Leu Val Ala Ile Gly Ala 
            100                 105                 110         


Met Asp Asn Ile Thr Glu Leu Arg Leu Ala His Arg Asp Leu Leu Lys 
        115                 120                 125             


Ser Ile Lys Asp Asn Asp Glu Ala Phe Glu Asp Ile Arg Ser Met Lys 
    130                 135                 140                 


Leu Asp His Glu Val Met Arg His Leu Thr Leu Pro Ser Ala Gln Lys 
145                 150                 155                 160 


Ala Arg Leu Ala Glu Glu Ala Ala Glu Ala Leu Thr Glu Lys Lys Thr 
                165                 170                 175     


Ala Thr Val Asp Ile Asn Tyr His Glu Leu Met Ala Gly Val Val Glu 
            180                 185                 190         


Leu Leu Thr Lys Lys Thr Lys Thr Val Gly Ser Asp Ser Thr Tyr Ser 
        195                 200                 205             


Phe Ser Arg Leu Ala Leu Gly Ile Gly Leu Ala Thr Gly Arg Arg Ser 
    210                 215                 220                 


Ile Glu Ile Leu Lys Gln Gly Glu Phe Lys Lys Val Asp Glu Gln Arg 
225                 230                 235                 240 


Leu Glu Phe Ser Gly Gln Ala Lys Lys Arg Gly Gly Ala Asp Tyr Ser 
                245                 250                 255     


Glu Thr Tyr Thr Ile Tyr Thr Leu Val Asp Ser Asp Leu Val Leu Met 
            260                 265                 270         


Ala Leu Lys Asn Leu Arg Glu Leu Pro Glu Val Arg Ala Leu Asp Glu 
        275                 280                 285             


Tyr Asp Gln Leu Gly Glu Ile Lys Arg Asn Asp Ala Ile Asn Lys Arg 
    290                 295                 300                 


Cys Ala Lys Thr Leu Asn Gln Thr Ala Lys Gln Phe Phe Gly Ser Asp 
305                 310                 315                 320 


Glu Arg Val Phe Lys Asp Ser Arg Ala Ile Trp Ala Arg Leu Ala Tyr 
                325                 330                 335     


Glu Leu Phe Phe Gln Arg Asp Pro Arg Trp Lys Lys Lys Asp Glu Asp 
            340                 345                 350         


Val Phe Trp Gln Glu Met Leu Gly His Glu Asp Ile Glu Thr Gln Lys 
        355                 360                 365             


Ala Tyr Lys Gln Phe Lys Val Asp Tyr Ser Glu Pro Glu Gln Pro Val 
    370                 375                 380                 


His Lys Pro Gly Lys Phe Lys Ser Arg Ala Glu Ala Leu Ala Ala Leu 
385                 390                 395                 400 


Asp Ser Asn Glu Asp Ile Thr Thr Arg Ser Ser Met Ala Lys Ile His 
                405                 410                 415     


Asp Trp Val Lys Glu Arg Ile Ala Glu Asp Pro Glu Ala Asn Ile Thr 
            420                 425                 430         


Gln Ser Leu Ile Thr Arg Glu Leu Gly Ser Gly Arg Lys Val Ile Lys 
        435                 440                 445             


Asp Tyr Leu Asp Leu Ala Asp Asp Ala Leu Ala Val Val Asn Thr Pro 
    450                 455                 460                 


Val Asp Asp Ala Val Val Glu Val Pro Ala Asp Val Pro Ala Ala Glu 
465                 470                 475                 480 


Lys Gln Pro Lys Lys Ala Gln Lys Pro Arg Leu Val Ala His Gln Val 
                485                 490                 495     


Asp Asp Glu His Trp Glu Ala Trp Ala Leu Val Glu Gly Glu Glu Val 
            500                 505                 510         


Ala Arg Val Lys Ile Lys Gly Thr Arg Val Glu Ala Met Thr Ala Ala 
        515                 520                 525             


Trp Glu Ala Ser Gln Lys Ala Leu Asp Asp 
    530                 535             


<210>  11
<211>  1896
<212>  DNA
<213>  Escherichia coli bacteriophage N15 protelomerase

<400>  11
atgagcaagg taaaaatcgg tgagttgatc aacacgcttg tgaatgaggt agaggcaatt       60

gatgcctcag accgcccaca aggcgacaaa acgaagagaa ttaaagccgc agccgcacgg      120

tataagaacg cgttatttaa tgataaaaga aagttccgtg ggaaaggatt gcagaaaaga      180

ataaccgcga atacttttaa cgcctatatg agcagggcaa gaaagcggtt tgatgataaa      240

ttacatcata gctttgataa aaatattaat aaattatcgg aaaagtatcc tctttacagc      300

gaagaattat cttcatggct ttctatgcct acggctaata ttcgccagca catgtcatcg      360

ttacaatcta aattgaaaga aataatgccg cttgccgaag agttatcaaa tgtaagaata      420

ggctctaaag gcagtgatgc aaaaatagca agactaataa aaaaatatcc agattggagt      480

tttgctctta gtgatttaaa cagtgatgat tggaaggagc gccgtgacta tctttataag      540

ttattccaac aaggctctgc gttgttagaa gaactacacc agctcaaggt caaccatgag      600

gttctgtacc atctgcagct aagccctgcg gagcgtacat ctatacagca acgatgggcc      660

gatgttctgc gcgagaagaa gcgtaatgtt gtggttattg actacccaac atacatgcag      720

tctatctatg atattttgaa taatcctgcg actttattta gtttaaacac tcgttctgga      780

atggcacctt tggcctttgc tctggctgcg gtatcagggc gaagaatgat tgagataatg      840

tttcagggtg aatttgccgt ttcaggaaag tatacggtta atttctcagg gcaagctaaa      900

aaacgctctg aagataaaag cgtaaccaga acgatttata ctttatgcga agcaaaatta      960

ttcgttgaat tattaacaga attgcgttct tgctctgctg catctgattt cgatgaggtt     1020

gttaaaggat atggaaagga tgatacaagg tctgagaacg gcaggataaa tgctatttta     1080

gcaaaagcat ttaacccttg ggttaaatca tttttcggcg atgaccgtcg tgtttataaa     1140

gatagccgcg ctatttacgc tcgcatcgct tatgagatgt tcttccgcgt cgatccacgg     1200

tggaaaaacg tcgacgagga tgtgttcttc atggagattc tcggacacga cgatgagaac     1260

acccagctgc actataagca gttcaagctg gccaacttct ccagaacctg gcgacctgaa     1320

gttggggatg aaaacaccag gctggtggct ctgcagaaac tggacgatga aatgccaggc     1380

tttgccagag gtgacgctgg cgtccgtctc catgaaaccg ttaagcagct ggtggagcag     1440

gacccatcag caaaaataac caacagcact ctccgggcct ttaaatttag cccgacgatg     1500

attagccggt acctggagtt tgccgctgat gcattggggc agttcgttgg cgagaacggg     1560

cagtggcagc tgaagataga gacacctgca atcgtcctgc ctgatgaaga atccgttgag     1620

accatcgacg aaccggatga tgagtcccaa gacgacgagc tggatgaaga tgaaattgag     1680

ctcgacgagg gtggcggcga tgaaccaacc gaagaggaag ggccagaaga acatcagcca     1740

actgctctaa aacccgtctt caagcctgca aaaaataacg gggacggaac gtacaagata     1800

gagtttgaat acgatggaaa gcattatgcc tggtccggcc ccgccgatag ccctatggcc     1860

gcaatgcgat ccgcatggga aacgtactac agctaa                               1896


<210>  12
<211>  631
<212>  PRT
<213>  Escherichia coli bacteriophage N15 protelomerase

<400>  12

Met Ser Lys Val Lys Ile Gly Glu Leu Ile Asn Thr Leu Val Asn Glu 
1               5                   10                  15      


Val Glu Ala Ile Asp Ala Ser Asp Arg Pro Gln Gly Asp Lys Thr Lys 
            20                  25                  30          


Arg Ile Lys Ala Ala Ala Ala Arg Tyr Lys Asn Ala Leu Phe Asn Asp 
        35                  40                  45              


Lys Arg Lys Phe Arg Gly Lys Gly Leu Gln Lys Arg Ile Thr Ala Asn 
    50                  55                  60                  


Thr Phe Asn Ala Tyr Met Ser Arg Ala Arg Lys Arg Phe Asp Asp Lys 
65                  70                  75                  80  


Leu His His Ser Phe Asp Lys Asn Ile Asn Lys Leu Ser Glu Lys Tyr 
                85                  90                  95      


Pro Leu Tyr Ser Glu Glu Leu Ser Ser Trp Leu Ser Met Pro Thr Ala 
            100                 105                 110         


Asn Ile Arg Gln His Met Ser Ser Leu Gln Ser Lys Leu Lys Glu Ile 
        115                 120                 125             


Met Pro Leu Ala Glu Glu Leu Ser Asn Val Arg Ile Gly Ser Lys Gly 
    130                 135                 140                 


Ser Asp Ala Lys Ile Ala Arg Leu Ile Lys Lys Tyr Pro Asp Trp Ser 
145                 150                 155                 160 


Phe Ala Leu Ser Asp Leu Asn Ser Asp Asp Trp Lys Glu Arg Arg Asp 
                165                 170                 175     


Tyr Leu Tyr Lys Leu Phe Gln Gln Gly Ser Ala Leu Leu Glu Glu Leu 
            180                 185                 190         


His Gln Leu Lys Val Asn His Glu Val Leu Tyr His Leu Gln Leu Ser 
        195                 200                 205             


Pro Ala Glu Arg Thr Ser Ile Gln Gln Arg Trp Ala Asp Val Leu Arg 
    210                 215                 220                 


Glu Lys Lys Arg Asn Val Val Val Ile Asp Tyr Pro Thr Tyr Met Gln 
225                 230                 235                 240 


Ser Ile Tyr Asp Ile Leu Asn Asn Pro Ala Thr Leu Phe Ser Leu Asn 
                245                 250                 255     


Thr Arg Ser Gly Met Ala Pro Leu Ala Phe Ala Leu Ala Ala Val Ser 
            260                 265                 270         


Gly Arg Arg Met Ile Glu Ile Met Phe Gln Gly Glu Phe Ala Val Ser 
        275                 280                 285             


Gly Lys Tyr Thr Val Asn Phe Ser Gly Gln Ala Lys Lys Arg Ser Glu 
    290                 295                 300                 


Asp Lys Ser Val Thr Arg Thr Ile Tyr Thr Leu Cys Glu Ala Lys Leu 
305                 310                 315                 320 


Phe Val Glu Leu Leu Thr Glu Leu Arg Ser Cys Ser Ala Ala Ser Asp 
                325                 330                 335     


Phe Asp Glu Val Val Lys Gly Tyr Gly Lys Asp Asp Thr Arg Ser Glu 
            340                 345                 350         


Asn Gly Arg Ile Asn Ala Ile Leu Ala Lys Ala Phe Asn Pro Trp Val 
        355                 360                 365             


Lys Ser Phe Phe Gly Asp Asp Arg Arg Val Tyr Lys Asp Ser Arg Ala 
    370                 375                 380                 


Ile Tyr Ala Arg Ile Ala Tyr Glu Met Phe Phe Arg Val Asp Pro Arg 
385                 390                 395                 400 


Trp Lys Asn Val Asp Glu Asp Val Phe Phe Met Glu Ile Leu Gly His 
                405                 410                 415     


Asp Asp Glu Asn Thr Gln Leu His Tyr Lys Gln Phe Lys Leu Ala Asn 
            420                 425                 430         


Phe Ser Arg Thr Trp Arg Pro Glu Val Gly Asp Glu Asn Thr Arg Leu 
        435                 440                 445             


Val Ala Leu Gln Lys Leu Asp Asp Glu Met Pro Gly Phe Ala Arg Gly 
    450                 455                 460                 


Asp Ala Gly Val Arg Leu His Glu Thr Val Lys Gln Leu Val Glu Gln 
465                 470                 475                 480 


Asp Pro Ser Ala Lys Ile Thr Asn Ser Thr Leu Arg Ala Phe Lys Phe 
                485                 490                 495     


Ser Pro Thr Met Ile Ser Arg Tyr Leu Glu Phe Ala Ala Asp Ala Leu 
            500                 505                 510         


Gly Gln Phe Val Gly Glu Asn Gly Gln Trp Gln Leu Lys Ile Glu Thr 
        515                 520                 525             


Pro Ala Ile Val Leu Pro Asp Glu Glu Ser Val Glu Thr Ile Asp Glu 
    530                 535                 540                 


Pro Asp Asp Glu Ser Gln Asp Asp Glu Leu Asp Glu Asp Glu Ile Glu 
545                 550                 555                 560 


Leu Asp Glu Gly Gly Gly Asp Glu Pro Thr Glu Glu Glu Gly Pro Glu 
                565                 570                 575     


Glu His Gln Pro Thr Ala Leu Lys Pro Val Phe Lys Pro Ala Lys Asn 
            580                 585                 590         


Asn Gly Asp Gly Thr Tyr Lys Ile Glu Phe Glu Tyr Asp Gly Lys His 
        595                 600                 605             


Tyr Ala Trp Ser Gly Pro Ala Asp Ser Pro Met Ala Ala Met Arg Ser 
    610                 615                 620                 


Ala Trp Glu Thr Tyr Tyr Ser 
625                 630     


<210>  13
<211>  1329
<212>  DNA
<213>  Agrobacterium tumefaciens str. C58 protelomerase

<400>  13
atgctcgccg caaaacgaaa aacaaaaaca ccggtcctcg tggaacgcat cgatcaattc       60

gtcggccaga tcaaagaggc gatgaaaagc gacgacgctt cgcgaaacag gaaaatccgc      120

gatctgtggg atgccgaggt ccgctatcat ttcgataatg gccgcacgga aaagacgctc      180

gaactttaca tcatgaaata tcgcaatgcg ctgaaggccg aattcggccc gaagagcacc      240

ccgctagcca tctgcaacat gaagaagctg cgcgagcgcc tgaacaccta tattgcccgg      300

ggcgattatc ccaagacagg cgtggcgacg tcgattgtcg aaaaaatcga gcgggcggag      360

ttcaacaccg ccggccgcaa acccacggtt ctccttcgca tagccgattt cattgccgcg      420

atgaacggca tggacgcgaa gcaggacatg caggctctgt gggacgcaga aatcgccatc      480

atgaacggcc gcgcccagac gacgatcatt tcctacatca ccaaatatcg caacgccatc      540

cgggaagcct tcggtgacga ccatccgatg ctgaagatcg ccaccggcga tgccgcgatg      600

tatgacgagg cccgccgggt gaagatggag aagatcgcca acaagcatgg cgcgctcatc      660

acattcgaga actaccggca ggttctgaaa atctgcgagg attgtctcaa gtccagcgat      720

cccctgatga tcggcatcgg cctcatcggc atgacgggac gccgacccta tgaagtcttc      780

acccaggcgg aattttcacc tgcaccctat ggcaagggag tttccaaatg gagcatcctg      840

ttcaacggtc aggccaagac gaaacagggc gagggcacga aattcgggat tacctatgaa      900

attcctgtcc tgacgcgctc cgaaaccgtg ctggctgcct ataagcgcct gcgcgaaagc      960

ggacagggaa aattatggca tggcatgtcg atcgacgatt tttcctcgga aacccgcctg     1020

ctgctgcgcg acacggtttt taacctgttc gaggatgtct ggccaaagga agagcttccc     1080

aagccctatg gcctcagaca cctctatgcc gaagtggcct atcacaattt cgcgccaccc     1140

catgtcacca agaacagcta tttcgccgcc attcttggcc acaacaataa cgacctcgaa     1200

acgtcgctgt cctatatgac ctatacgctg ccggaagacc gcgacaatgc gctggcgcgc     1260

ctgaagcgga ccaatgagcg gacattgcag caaatggcga cgatcgcgcc cgtgtcccgc     1320

aagggatga                                                             1329


<210>  14
<211>  442
<212>  PRT
<213>  Agrobacterium tumefaciens str. C58 protelomerase

<400>  14

Met Leu Ala Ala Lys Arg Lys Thr Lys Thr Pro Val Leu Val Glu Arg 
1               5                   10                  15      


Ile Asp Gln Phe Val Gly Gln Ile Lys Glu Ala Met Lys Ser Asp Asp 
            20                  25                  30          


Ala Ser Arg Asn Arg Lys Ile Arg Asp Leu Trp Asp Ala Glu Val Arg 
        35                  40                  45              


Tyr His Phe Asp Asn Gly Arg Thr Glu Lys Thr Leu Glu Leu Tyr Ile 
    50                  55                  60                  


Met Lys Tyr Arg Asn Ala Leu Lys Ala Glu Phe Gly Pro Lys Ser Thr 
65                  70                  75                  80  


Pro Leu Ala Ile Cys Asn Met Lys Lys Leu Arg Glu Arg Leu Asn Thr 
                85                  90                  95      


Tyr Ile Ala Arg Gly Asp Tyr Pro Lys Thr Gly Val Ala Thr Ser Ile 
            100                 105                 110         


Val Glu Lys Ile Glu Arg Ala Glu Phe Asn Thr Ala Gly Arg Lys Pro 
        115                 120                 125             


Thr Val Leu Leu Arg Ile Ala Asp Phe Ile Ala Ala Met Asn Gly Met 
    130                 135                 140                 


Asp Ala Lys Gln Asp Met Gln Ala Leu Trp Asp Ala Glu Ile Ala Ile 
145                 150                 155                 160 


Met Asn Gly Arg Ala Gln Thr Thr Ile Ile Ser Tyr Ile Thr Lys Tyr 
                165                 170                 175     


Arg Asn Ala Ile Arg Glu Ala Phe Gly Asp Asp His Pro Met Leu Lys 
            180                 185                 190         


Ile Ala Thr Gly Asp Ala Ala Met Tyr Asp Glu Ala Arg Arg Val Lys 
        195                 200                 205             


Met Glu Lys Ile Ala Asn Lys His Gly Ala Leu Ile Thr Phe Glu Asn 
    210                 215                 220                 


Tyr Arg Gln Val Leu Lys Ile Cys Glu Asp Cys Leu Lys Ser Ser Asp 
225                 230                 235                 240 


Pro Leu Met Ile Gly Ile Gly Leu Ile Gly Met Thr Gly Arg Arg Pro 
                245                 250                 255     


Tyr Glu Val Phe Thr Gln Ala Glu Phe Ser Pro Ala Pro Tyr Gly Lys 
            260                 265                 270         


Gly Val Ser Lys Trp Ser Ile Leu Phe Asn Gly Gln Ala Lys Thr Lys 
        275                 280                 285             


Gln Gly Glu Gly Thr Lys Phe Gly Ile Thr Tyr Glu Ile Pro Val Leu 
    290                 295                 300                 


Thr Arg Ser Glu Thr Val Leu Ala Ala Tyr Lys Arg Leu Arg Glu Ser 
305                 310                 315                 320 


Gly Gln Gly Lys Leu Trp His Gly Met Ser Ile Asp Asp Phe Ser Ser 
                325                 330                 335     


Glu Thr Arg Leu Leu Leu Arg Asp Thr Val Phe Asn Leu Phe Glu Asp 
            340                 345                 350         


Val Trp Pro Lys Glu Glu Leu Pro Lys Pro Tyr Gly Leu Arg His Leu 
        355                 360                 365             


Tyr Ala Glu Val Ala Tyr His Asn Phe Ala Pro Pro His Val Thr Lys 
    370                 375                 380                 


Asn Ser Tyr Phe Ala Ala Ile Leu Gly His Asn Asn Asn Asp Leu Glu 
385                 390                 395                 400 


Thr Ser Leu Ser Tyr Met Thr Tyr Thr Leu Pro Glu Asp Arg Asp Asn 
                405                 410                 415     


Ala Leu Ala Arg Leu Lys Arg Thr Asn Glu Arg Thr Leu Gln Gln Met 
            420                 425                 430         


Ala Thr Ile Ala Pro Val Ser Arg Lys Gly 
        435                 440         


<210>  15
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  minimal substrate sequence for the Agrobacterium tumefaciens str.
       C58 protelomerase

<400>  15
aataacaata tcatgatatt gttatt                                            26


<210>  16
<211>  2631
<212>  DNA
<213>  DNA polymerase 1 of Geobacillus stearothermophilus

<400>  16
atgaagaaga agctagtact aattgatggc aacagtgtgg cataccgcgc cttttttgcc       60

ttgccacttt tgcataacga caaaggcatt catacgaatg cggtttacgg gtttacgatg      120

atgttgaaca aaattttggc ggaagaacaa ccgacccatt tacttgtagc gtttgacgcc      180

ggaaaaacga cgttccggca tgaaacgttt caagagtata aaggcggacg gcaacaaact      240

cccccggaac tgtccgagca gtttccgctg ttgcgcgagc tattaaaagc gtaccgcatt      300

cccgcttatg aacttgatca ttacgaagcg gacgatatta tcgggacgct cgctgcccgc      360

gctgagcaag aagggtttga agtgaaaatc atttccggcg accgcgattt aacccagctc      420

gcctcccgtc atgtgacggt cgatattacg aaaaaaggga ttaccgacat tgagccgtat      480

acgccagaga ccgttcgcga aaaatacggc ctgactccgg agcaaatagt ggatttaaaa      540

ggattgatgg gcgataaatc cgacaacatc ccgggcgtgc ccggcatcgg ggaaaaaacg      600

gcggtcaagc tgctgaagca atttggtacg gtggaaaatg tgctcgcatc gattgatgag      660

gtgaaagggg aaaaactgaa agaaaacttg cgccaacacc gggatttagc tctcttgagc      720

aaacagctgg cgtccatttg ccgcgacgcc ccggttgagc tgtcgttaga tgacattgtc      780

tacgaaggac aagaccgcga aaaagtcatc gcgttattta aagaactcgg gtttcagtcg      840

ttcttggaaa aaatggccgc gccggcagcc gaaggggaga aaccgcttga ggagatggag      900

tttgccatcg ttgacgtcat taccgaagag atgcttgccg acaaggcagc gcttgtcgtt      960

gaggtgatgg aagaaaacta ccacgatgcc ccgattgtcg gaatcgcact agtgaacgag     1020

catgggcgat tttttatgcg cccggagacc gcgctggctg attcgcaatt tttagcatgg     1080

cttgccgatg aaacgaagaa aaaaagcatg tttgacgcca agcgggcagt cgttgcctta     1140

aagtggaaag gaattgagct tcgcggcgtc gcctttgatt tattgctcgc tgcctatttg     1200

ctcaatccgg ctcaagatgc cggcgatatc gctgcggtgg cgaaaatgaa acaatatgaa     1260

gcggtgcggt cggatgaagc ggtctatggc aaaggcgtca agcggtcgct gccggacgaa     1320

cagacgcttg ctgagcatct cgttcgcaaa gcggcagcca tttgggcgct tgagcagccg     1380

tttatggacg atttgcggaa caacgaacaa gatcaattat taacgaagct tgagcagccg     1440

ctggcggcga ttttggctga aatggaattc actggggtga acgtggatac aaagcggctt     1500

gaacagatgg gttcggagct cgccgaacaa ctgcgtgcca tcgagcagcg catttacgag     1560

ctagccggcc aagagttcaa cattaactca ccaaaacagc tcggagtcat tttatttgaa     1620

aagctgcagc taccggtgct gaagaagacg aaaacaggct attcgacttc ggctgatgtg     1680

cttgagaagc ttgcgccgca tcatgaaatc gtcgaaaaca ttttgcatta ccgccagctt     1740

ggcaaactgc aatcaacgta tattgaagga ttgttgaaag ttgtgcgccc tgataccggc     1800

aaagtgcata cgatgttcaa ccaagcgctg acgcaaactg ggcggctcag ctcggccgag     1860

ccgaacttgc aaaacattcc gattcggctc gaagaggggc ggaaaatccg ccaagcgttc     1920

gtcccgtcag agccggactg gctcattttc gccgccgatt actcacaaat tgaattgcgc     1980

gtcctcgccc atatcgccga tgacgacaat ctaattgaag cgttccaacg cgatttggat     2040

attcacacaa aaacggcgat ggacattttc catgtgagcg aagaggaagt cacggccaac     2100

atgcgccgcc aggcaaaggc cgttaacttc ggtatcgttt acggaattag cgattacgga     2160

ttggcgcaaa acttgaacat tacgcgcaaa gaagctgccg aatttatcga acgttacttc     2220

gccagctttc cgggcgtaaa gcagtatatg gaaaacattg tgcaagaagc gaaacagaaa     2280

ggatatgtga caacgctgtt gcatcggcgc cgctatttgc ctgatattac aagccgcaat     2340

ttcaacgtcc gcagttttgc agagcggacg gccatgaaca cgccaattca aggaagcgcc     2400

gctgacatta ttaaaaaagc gatgattgat ttagcggcac ggctgaaaga agagcagctt     2460

caggctcgtc ttttgctgca agtgcatgac gagctcattt tggaagcgcc aaaagaggaa     2520

attgagcgat tatgtgagct tgttccggaa gtgatggagc aggccgttac gctccgcgtg     2580

ccgctgaaag tcgactacca ttacggccca acatggtatg atgccaaata a              2631


<210>  17
<211>  587
<212>  PRT
<213>  DNA Polymerase of Geobacillus stearothermophilus

<400>  17

Ala Glu Gly Glu Lys Pro Leu Glu Glu Met Glu Phe Ala Ile Val Asp 
1               5                   10                  15      


Val Ile Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val Glu 
            20                  25                  30          


Val Met Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala Leu 
        35                  40                  45              


Val Asn Glu His Gly Arg Phe Phe Met Arg Pro Glu Thr Ala Leu Ala 
    50                  55                  60                  


Asp Ser Gln Phe Leu Ala Trp Leu Ala Asp Glu Thr Lys Lys Lys Ser 
65                  70                  75                  80  


Met Phe Asp Ala Lys Arg Ala Val Val Ala Leu Lys Trp Lys Gly Ile 
                85                  90                  95      


Glu Leu Arg Gly Val Ala Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu 
            100                 105                 110         


Asn Pro Ala Gln Asp Ala Gly Asp Ile Ala Ala Val Ala Lys Met Lys 
        115                 120                 125             


Gln Tyr Glu Ala Val Arg Ser Asp Glu Ala Val Tyr Gly Lys Gly Val 
    130                 135                 140                 


Lys Arg Ser Leu Pro Asp Glu Gln Thr Leu Ala Glu His Leu Val Arg 
145                 150                 155                 160 


Lys Ala Ala Ala Ile Trp Ala Leu Glu Gln Pro Phe Met Asp Asp Leu 
                165                 170                 175     


Arg Asn Asn Glu Gln Asp Gln Leu Leu Thr Lys Leu Glu Gln Pro Leu 
            180                 185                 190         


Ala Ala Ile Leu Ala Glu Met Glu Phe Thr Gly Val Asn Val Asp Thr 
        195                 200                 205             


Lys Arg Leu Glu Gln Met Gly Ser Glu Leu Ala Glu Gln Leu Arg Ala 
    210                 215                 220                 


Ile Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn 
225                 230                 235                 240 


Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu Pro 
                245                 250                 255     


Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu 
            260                 265                 270         


Glu Lys Leu Ala Pro His His Glu Ile Val Glu Asn Ile Leu His Tyr 
        275                 280                 285             


Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys 
    290                 295                 300                 


Val Val Arg Pro Asp Thr Gly Lys Val His Thr Met Phe Asn Gln Ala 
305                 310                 315                 320 


Leu Thr Gln Thr Gly Arg Leu Ser Ser Ala Glu Pro Asn Leu Gln Asn 
                325                 330                 335     


Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe Val 
            340                 345                 350         


Pro Ser Glu Pro Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile 
        355                 360                 365             


Glu Leu Arg Val Leu Ala His Ile Ala Asp Asp Asp Asn Leu Ile Glu 
    370                 375                 380                 


Ala Phe Gln Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp Ile 
385                 390                 395                 400 


Phe His Val Ser Glu Glu Glu Val Thr Ala Asn Met Arg Arg Gln Ala 
                405                 410                 415     


Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Asp Tyr Gly Leu 
            420                 425                 430         


Ala Gln Asn Leu Asn Ile Thr Arg Lys Glu Ala Ala Glu Phe Ile Glu 
        435                 440                 445             


Arg Tyr Phe Ala Ser Phe Pro Gly Val Lys Gln Tyr Met Glu Asn Ile 
    450                 455                 460                 


Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His Arg 
465                 470                 475                 480 


Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Asn Val Arg Ser 
                485                 490                 495     


Phe Ala Glu Arg Thr Ala Met Asn Thr Pro Ile Gln Gly Ser Ala Ala 
            500                 505                 510         


Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Ala Ala Arg Leu Lys Glu 
        515                 520                 525             


Glu Gln Leu Gln Ala Arg Leu Leu Leu Gln Val His Asp Glu Leu Ile 
    530                 535                 540                 


Leu Glu Ala Pro Lys Glu Glu Ile Glu Arg Leu Cys Glu Leu Val Pro 
545                 550                 555                 560 


Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val Asp 
                565                 570                 575     


Tyr His Tyr Gly Pro Thr Trp Tyr Asp Ala Lys 
            580                 585         


