                         SEQUENCE LISTING

<110>  UCB Pharma S.A.
 
<120>  Anti-FcRn Antibodies

<130>  G0165

<150>  GB1208370.5
<151>  2012-05-14

<160>  94   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CA170_1519 CDRH1

<400>  1

Gly Phe Thr Phe Ser Asn Tyr Gly Met Val 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CA170_1519 CDRH2

<400>  2

Tyr Ile Asp Ser Asp Gly Asp Asn Thr Tyr Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  CA170_1519 CDRH3

<400>  3

Gly Ile Val Arg Pro Phe Leu Tyr 
1               5               


<210>  4
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  CA170_1519 CDRL1

<400>  4

Lys Ser Ser Gln Ser Leu Val Gly Ala Ser Gly Lys Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CA170_1519 CDRL2

<400>  5

Leu Val Ser Thr Leu Asp Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CA170_1519 CDRL3

<400>  6

Leu Gln Gly Thr His Phe Pro His Thr 
1               5                   


<210>  7
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Rat Ab 1519 VL region

<400>  7

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ala Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val Gly Ala 
            20                  25                  30          


Ser Gly Lys Thr Tyr Leu Tyr Trp Leu Phe Gln Arg Ser Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Thr Leu Asp Ser Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Glu Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Arg Arg Val Glu Ala Asp Asp Leu Gly Val Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr His Phe Pro His Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  8
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Rat Ab 1519 VL region

<400>  8
gatgttgtga tgacccagac tccactgtct ttgtcggttg cccttggaca accagcctcc       60

atctcttgca agtcaagtca gagcctcgta ggtgctagtg gaaagacata tttgtattgg      120

ttatttcaga ggtccggcca gtctccaaag cgactaatct atctggtgtc cacactggac      180

tctggaattc ctgataggtt cagtggcagt ggagcagaga cagattttac tcttaaaatc      240

cgcagagtgg aagccgatga tttgggagtt tattactgct tgcaaggtac acattttcct      300

cacacgtttg gagctgggac caagctggaa ttgaaa                                336


<210>  9
<211>  132
<212>  PRT
<213>  Artificial

<220>
<223>  Rat Ab 1519 VL region with signal sequence 

<400>  9

Met Met Ser Pro Ala Gln Phe Leu Phe Leu Leu Met Leu Trp Ile Gln 
1               5                   10                  15      


Gly Thr Ser Gly Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Ser 
            20                  25                  30          


Val Ala Leu Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Val Gly Ala Ser Gly Lys Thr Tyr Leu Tyr Trp Leu Phe Gln Arg 
    50                  55                  60                  


Ser Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Thr Leu Asp 
65                  70                  75                  80  


Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ala Glu Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Arg Arg Val Glu Ala Asp Asp Leu Gly Val Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Gly Thr His Phe Pro His Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys 
    130         


<210>  10
<211>  396
<212>  DNA
<213>  Artificial

<220>
<223>  Rat Ab 1519 VL region with signal sequence 

<400>  10
atgatgagtc ctgcccagtt cctgtttctg ctgatgctct ggattcaggg aaccagtggt       60

gatgttgtga tgacccagac tccactgtct ttgtcggttg cccttggaca accagcctcc      120

atctcttgca agtcaagtca gagcctcgta ggtgctagtg gaaagacata tttgtattgg      180

ttatttcaga ggtccggcca gtctccaaag cgactaatct atctggtgtc cacactggac      240

tctggaattc ctgataggtt cagtggcagt ggagcagaga cagattttac tcttaaaatc      300

cgcagagtgg aagccgatga tttgggagtt tattactgct tgcaaggtac acattttcct      360

cacacgtttg gagctgggac caagctggaa ttgaaa                                396


<210>  11
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Rat Ab 1519 VH region

<400>  11

Glu Val Pro Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Val Trp Val Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asp Ser Asp Gly Asp Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Gly Ile Val Arg Pro Phe Leu Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser 
        115     


<210>  12
<211>  348
<212>  DNA
<213>  Artificial

<220>
<223>  Rat Ab 1519 VH region

<400>  12
gaggtgccgc tggtggagtc tgggggcggc tcagtgcagc ctgggaggtc catgaaactc       60

tcctgtgtag tctcaggatt cactttcagt aattatggca tggtctgggt ccgccaggct      120

ccaaagaagg gtctggagtg ggtcgcatat attgattctg atggtgataa tacttactac      180

cgagattccg tgaagggccg attcactatc tccagaaata atgcaaaaag caccctatat      240

ttgcaaatgg acagtctgag gtctgaggac acggccactt attactgtac aacagggatt      300

gtccggccct ttctctattg gggccaagga accacggtca ccgtctcg                   348


<210>  13
<211>  135
<212>  PRT
<213>  Artificial

<220>
<223>  Rat Ab 1519 VH region with signal sequence 

<400>  13

Met Asp Ile Ser Leu Ser Leu Ala Phe Leu Val Leu Phe Ile Lys Gly 
1               5                   10                  15      


Val Arg Cys Glu Val Pro Leu Val Glu Ser Gly Gly Gly Ser Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Met Lys Leu Ser Cys Val Val Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Gly Met Val Trp Val Arg Gln Ala Pro Lys Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Tyr Ile Asp Ser Asp Gly Asp Asn Thr Tyr Tyr Arg 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Lys Ser 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Thr Thr Gly Ile Val Arg Pro Phe Leu Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser 
    130                 135 


<210>  14
<211>  405
<212>  DNA
<213>  Artificial

<220>
<223>  Rat Ab 1519 VH region with signal sequence 

<400>  14
atggacatca gtctcagctt ggctttcctt gtccttttca taaaaggtgt ccggtgtgag       60

gtgccgctgg tggagtctgg gggcggctca gtgcagcctg ggaggtccat gaaactctcc      120

tgtgtagtct caggattcac tttcagtaat tatggcatgg tctgggtccg ccaggctcca      180

aagaagggtc tggagtgggt cgcatatatt gattctgatg gtgataatac ttactaccga      240

gattccgtga agggccgatt cactatctcc agaaataatg caaaaagcac cctatatttg      300

caaatggaca gtctgaggtc tgaggacacg gccacttatt actgtacaac agggattgtc      360

cggccctttc tctattgggg ccaaggaacc acggtcaccg tctcg                      405


<210>  15
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  1519 gL20 V-region

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Val Gly Ala 
            20                  25                  30          


Ser Gly Lys Thr Tyr Leu Tyr Trp Leu Phe Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Thr Leu Asp Ser Gly Ile Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr His Phe Pro His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  16
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  1519 gL20 V-region (E. coli expression)

<400>  16
gatatccaga tgacccagag tccaagcagt ctctccgcca gcgtaggcga tcgtgtgact       60

attacctgta aaagctccca gtccctggtg ggtgcaagcg gcaaaaccta cctgtactgg      120

ctcttccaga aaccgggcaa agctccgaaa cgcctgatct atctggtgtc taccctggat      180

agcggtattc cgtctcgttt ctccggtagc ggtagcggta ccgaattcac gctgaccatt      240

agctccctcc agccggagga ctttgctacc tattactgcc tccagggcac tcattttccg      300

cacactttcg gccagggtac caaactggaa atcaaa                                336


<210>  17
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  1519 gL20 V-region (mammalian expression)

<400>  17
gatatccaga tgacccagag cccatctagc ttatccgctt ccgttggtga tcgcgtgaca       60

attacgtgta agagctccca atctctcgtg ggtgcaagtg gcaagaccta tctgtactgg      120

ctctttcaga agcctggcaa ggcaccaaaa cggctgatct atctggtgtc tacccttgac      180

tctgggatac cgtcacgatt ttccggatct gggagcggaa ctgagttcac actcacgatt      240

tcatcgctgc aacccgagga ctttgctacc tactactgcc tgcaaggcac tcatttccct      300

cacactttcg gccaggggac aaaactcgaa atcaaa                                336


<210>  18
<211>  133
<212>  PRT
<213>  Artificial

<220>
<223>  1519 gL20 V-region with signal sequence (E. coli expression)

<400>  18

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Leu Val Gly Ala Ser Gly Lys Thr Tyr Leu Tyr Trp Leu Phe Gln 
    50                  55                  60                  


Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr Leu Val Ser Thr Leu 
65                  70                  75                  80  


Asp Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Leu Gln Gly Thr His Phe Pro His Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys 
    130             


<210>  19
<211>  399
<212>  DNA
<213>  Artificial

<220>
<223>  1519 gL20 V-region with signal sequence (E. coli expression)

<400>  19
atgaaaaaga cagctatcgc aattgcagtg gccttggctg gtttcgctac cgtagcgcaa       60

gctgatatcc agatgaccca gagtccaagc agtctctccg ccagcgtagg cgatcgtgtg      120

actattacct gtaaaagctc ccagtccctg gtgggtgcaa gcggcaaaac ctacctgtac      180

tggctcttcc agaaaccggg caaagctccg aaacgcctga tctatctggt gtctaccctg      240

gatagcggta ttccgtctcg tttctccggt agcggtagcg gtaccgaatt cacgctgacc      300

attagctccc tccagccgga ggactttgct acctattact gcctccaggg cactcatttt      360

ccgcacactt tcggccaggg taccaaactg gaaatcaaa                             399


<210>  20
<211>  132
<212>  PRT
<213>  Artificial

<220>
<223>  1519 gL20 V-region with signal sequence (mammalian expression)

<400>  20

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Val Gly Ala Ser Gly Lys Thr Tyr Leu Tyr Trp Leu Phe Gln Lys 
    50                  55                  60                  


Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr Leu Val Ser Thr Leu Asp 
65                  70                  75                  80  


Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Gly Thr His Phe Pro His Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys 
    130         


<210>  21
<211>  396
<212>  DNA
<213>  Artificial

<220>
<223>  1519 gL20 V-region with signal sequence (mammalian expression)

<400>  21
atgtctgtcc ccacccaagt cctcggactc ctgctactct ggcttacaga tgccagatgc       60

gatatccaga tgacccagag cccatctagc ttatccgctt ccgttggtga tcgcgtgaca      120

attacgtgta agagctccca atctctcgtg ggtgcaagtg gcaagaccta tctgtactgg      180

ctctttcaga agcctggcaa ggcaccaaaa cggctgatct atctggtgtc tacccttgac      240

tctgggatac cgtcacgatt ttccggatct gggagcggaa ctgagttcac actcacgatt      300

tcatcgctgc aacccgagga ctttgctacc tactactgcc tgcaaggcac tcatttccct      360

cacactttcg gccaggggac aaaactcgaa atcaaa                                396


<210>  22
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  1519 gL20 light chain (V + constant)

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Val Gly Ala 
            20                  25                  30          


Ser Gly Lys Thr Tyr Leu Tyr Trp Leu Phe Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Thr Leu Asp Ser Gly Ile Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr His Phe Pro His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  23
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  1519 gL20 light chain (V + constant, E. coli expression)

<400>  23
gatatccaga tgacccagag tccaagcagt ctctccgcca gcgtaggcga tcgtgtgact       60

attacctgta aaagctccca gtccctggtg ggtgcaagcg gcaaaaccta cctgtactgg      120

ctcttccaga aaccgggcaa agctccgaaa cgcctgatct atctggtgtc taccctggat      180

agcggtattc cgtctcgttt ctccggtagc ggtagcggta ccgaattcac gctgaccatt      240

agctccctcc agccggagga ctttgctacc tattactgcc tccagggcac tcattttccg      300

cacactttcg gccagggtac caaactggaa atcaaacgta cggtagcggc cccatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcaccagta acaaaaagtt ttaatagagg ggagtgt         657


<210>  24
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  1519 gL20 light chain (V + constant, mammalian expression)

<400>  24
gatatccaga tgacccagag tccaagcagt ctctccgcca gcgtaggcga tcgtgtgact       60

attacctgta aaagctccca gtccctggtg ggtgcaagcg gcaaaaccta cctgtactgg      120

ctcttccaga aaccgggcaa agctccgaaa cgcctgatct atctggtgtc taccctggat      180

agcggtattc cgtctcgttt ctccggtagc ggtagcggta ccgaattcac gctgaccatt      240

agctccctcc agccggagga ctttgctacc tattactgcc tccagggcac tcattttccg      300

cacactttcg gccagggtac caaactggaa atcaaacgta cggtagcggc cccatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  25
<211>  240
<212>  PRT
<213>  Artificial

<220>
<223>  1519 gL20 light chain with signal sequence (E. coli expression)

<400>  25

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Leu Val Gly Ala Ser Gly Lys Thr Tyr Leu Tyr Trp Leu Phe Gln 
    50                  55                  60                  


Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr Leu Val Ser Thr Leu 
65                  70                  75                  80  


Asp Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Leu Gln Gly Thr His Phe Pro His Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  26
<211>  720
<212>  DNA
<213>  Artificial

<220>
<223>  1519 gL20 light chain with signal sequence (E. coli expression)

<400>  26
atgaaaaaga cagctatcgc aattgcagtg gccttggctg gtttcgctac cgtagcgcaa       60

gctgatatcc agatgaccca gagtccaagc agtctctccg ccagcgtagg cgatcgtgtg      120

actattacct gtaaaagctc ccagtccctg gtgggtgcaa gcggcaaaac ctacctgtac      180

tggctcttcc agaaaccggg caaagctccg aaacgcctga tctatctggt gtctaccctg      240

gatagcggta ttccgtctcg tttctccggt agcggtagcg gtaccgaatt cacgctgacc      300

attagctccc tccagccgga ggactttgct acctattact gcctccaggg cactcatttt      360

ccgcacactt tcggccaggg taccaaactg gaaatcaaac gtacggtagc ggccccatct      420

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      480

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      540

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      600

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      660

gaagtcaccc atcagggcct gagctcacca gtaacaaaaa gttttaatag aggggagtgt      720


<210>  27
<211>  239
<212>  PRT
<213>  Artificial

<220>
<223>  1519 gL20 light chain with signal sequence (mammalian expression)

<400>  27

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Val Gly Ala Ser Gly Lys Thr Tyr Leu Tyr Trp Leu Phe Gln Lys 
    50                  55                  60                  


Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr Leu Val Ser Thr Leu Asp 
65                  70                  75                  80  


Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Gly Thr His Phe Pro His Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  28
<211>  717
<212>  DNA
<213>  Artificial

<220>
<223>  1519 gL20 light chain with signal sequence (mammalian expression)

<400>  28
atgtctgtcc ccacccaagt cctcggactc ctgctactct ggcttacaga tgccagatgc       60

gatatccaga tgacccagag cccatctagc ttatccgctt ccgttggtga tcgcgtgaca      120

attacgtgta agagctccca atctctcgtg ggtgcaagtg gcaagaccta tctgtactgg      180

ctctttcaga agcctggcaa ggcaccaaaa cggctgatct atctggtgtc tacccttgac      240

tctgggatac cgtcacgatt ttccggatct gggagcggaa ctgagttcac actcacgatt      300

tcatcgctgc aacccgagga ctttgctacc tactactgcc tgcaaggcac tcatttccct      360

cacactttcg gccaggggac aaaactcgaa atcaaacgta cggtagcggc cccatctgtc      420

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      480

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      540

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      600

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      660

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         717


<210>  29
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  1519 gH20 V-region

<400>  29

Glu Val Pro Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asp Ser Asp Gly Asp Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Gly Ile Val Arg Pro Phe Leu Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser 
        115     


<210>  30
<211>  348
<212>  DNA
<213>  Artificial

<220>
<223>  1519 gH20 V-region (E. coli expression)

<400>  30
gaggttccgc tggtcgagtc tggaggcggg cttgtccagc ctggagggag cctgcgtctc       60

tcttgtgcag tatctggctt cacgttctcc aactacggta tggtgtgggt tcgtcaggct      120

ccaggtaaag gtctggaatg ggtggcgtat attgactccg acggcgacaa cacctactat      180

cgcgactctg tgaaaggtcg cttcaccatt tcccgcgata acgccaaatc cagcctgtac      240

ctgcagatga acagcctgcg tgctgaagat actgcggtgt actattgcac cactggcatc      300

gtgcgtccgt ttctgtattg gggtcagggt accctcgtta ctgtctcg                   348


<210>  31
<211>  348
<212>  DNA
<213>  Artificial

<220>
<223>  1519 gH20 V-region (mammalian expression)

<400>  31
gaggtaccac ttgtggaaag cggaggaggt cttgtgcagc ctggaggaag tttacgtctc       60

tcttgtgctg tgtctggctt caccttctcc aattacggaa tggtctgggt cagacaagca      120

cctggaaagg gtcttgaatg ggtggcctat attgactctg acggggacaa cacctactat      180

cgggattccg tgaaaggacg cttcacaatc tcccgagata acgccaagag ctcactgtac      240

ctgcagatga atagcctgag agccgaggat actgccgtgt actattgcac aacgggaatc      300

gttaggcctt ttctgtactg gggacagggc accttggtta ctgtctcg                   348


<210>  32
<211>  137
<212>  PRT
<213>  Artificial

<220>
<223>  1519 gH20 V-region (E. coli expression)

<400>  32

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Glu Val Pro Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Asn Tyr Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Tyr Ile Asp Ser Asp Gly Asp Asn Thr Tyr 
65                  70                  75                  80  


Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Ser Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Thr Gly Ile Val Arg Pro Phe Leu Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135         


<210>  33
<211>  411
<212>  DNA
<213>  Artificial

<220>
<223>  1519 gH20 V-region (E. coli expression)

<400>  33
atgaagaaga ctgctatagc aattgcagtg gcgctagctg gtttcgccac cgtggcgcaa       60

gctgaggttc cgctggtcga gtctggaggc gggcttgtcc agcctggagg gagcctgcgt      120

ctctcttgtg cagtatctgg cttcacgttc tccaactacg gtatggtgtg ggttcgtcag      180

gctccaggta aaggtctgga atgggtggcg tatattgact ccgacggcga caacacctac      240

tatcgcgact ctgtgaaagg tcgcttcacc atttcccgcg ataacgccaa atccagcctg      300

tacctgcaga tgaacagcct gcgtgctgaa gatactgcgg tgtactattg caccactggc      360

atcgtgcgtc cgtttctgta ttggggtcag ggtaccctcg ttactgtctc g               411


<210>  34
<211>  135
<212>  PRT
<213>  Artificial

<220>
<223>  1519 gH20 V-region (mammalian expression)

<400>  34

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Pro Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Tyr Ile Asp Ser Asp Gly Asp Asn Thr Tyr Tyr Arg 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Thr Gly Ile Val Arg Pro Phe Leu Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser 
    130                 135 


<210>  35
<211>  405
<212>  DNA
<213>  Artificial

<220>
<223>  1519 gH20 V-region with signal sequence (mammalian expression)

<400>  35
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa ctacaggagt ccattctgag       60

gtaccacttg tggaaagcgg aggaggtctt gtgcagcctg gaggaagttt acgtctctct      120

tgtgctgtgt ctggcttcac cttctccaat tacggaatgg tctgggtcag acaagcacct      180

ggaaagggtc ttgaatgggt ggcctatatt gactctgacg gggacaacac ctactatcgg      240

gattccgtga aaggacgctt cacaatctcc cgagataacg ccaagagctc actgtacctg      300

cagatgaata gcctgagagc cgaggatact gccgtgtact attgcacaac gggaatcgtt      360

aggccttttc tgtactgggg acagggcacc ttggttactg tctcg                      405


<210>  36
<211>  228
<212>  PRT
<213>  Artificial

<220>
<223>  1519gH20 Fab' heavy chain (V + human gamma-1 CH1 + hinge)

<400>  36

Glu Val Pro Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asp Ser Asp Gly Asp Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Gly Ile Val Arg Pro Phe Leu Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Ala Ala 
225             


<210>  37
<211>  684
<212>  DNA
<213>  Artificial

<220>
<223>  1519gH20 Fab' heavy chain (V + human gamma-1 CH1 + hinge, E.coli 
       expression)

<400>  37
gaggttccgc tggtcgagtc tggaggcggg cttgtccagc ctggagggag cctgcgtctc       60

tcttgtgcag tatctggctt cacgttctcc aactacggta tggtgtgggt tcgtcaggct      120

ccaggtaaag gtctggaatg ggtggcgtat attgactccg acggcgacaa cacctactat      180

cgcgactctg tgaaaggtcg cttcaccatt tcccgcgata acgccaaatc cagcctgtac      240

ctgcagatga acagcctgcg tgctgaagat actgcggtgt actattgcac cactggcatc      300

gtgcgtccgt ttctgtattg gggtcagggt accctcgtta ctgtctcgag cgcttctaca      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtcgacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgcgc cgcg                                             684


<210>  38
<211>  684
<212>  DNA
<213>  Artificial

<220>
<223>  1519gH20 Fab' heavy chain (V + human gamma-1 CH1 + hinge, 
       mammalian expression)

<400>  38
gaggtaccac ttgtggaaag cggaggaggt cttgtgcagc ctggaggaag tttacgtctc       60

tcttgtgctg tgtctggctt caccttctcc aattacggaa tggtctgggt cagacaagca      120

cctggaaagg gtcttgaatg ggtggcctat attgactctg acggggacaa cacctactat      180

cgggattccg tgaaaggacg cttcacaatc tcccgagata acgccaagag ctcactgtac      240

ctgcagatga atagcctgag agccgaggat actgccgtgt actattgcac aacgggaatc      300

gttaggcctt ttctgtactg gggacagggc accttggtta ctgtctcgag cgcttctaca      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtcgacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgcgc cgcg                                             684


<210>  39
<211>  249
<212>  PRT
<213>  Artificial

<220>
<223>  1519 gH20 Fab' heavy chain with signal sequence (E. coli expression)

<400>  39

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Glu Val Pro Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Asn Tyr Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Tyr Ile Asp Ser Asp Gly Asp Asn Thr Tyr 
65                  70                  75                  80  


Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Ser Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Thr Gly Ile Val Arg Pro Phe Leu Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Ala Ala 
                245                 


<210>  40
<211>  747
<212>  DNA
<213>  Artificial

<220>
<223>  1519 gH20 Fab' heavy chain with signal sequence (E. coli expression)

<400>  40
atgaagaaga ctgctatagc aattgcagtg gcgctagctg gtttcgccac cgtggcgcaa       60

gctgaggttc cgctggtcga gtctggaggc gggcttgtcc agcctggagg gagcctgcgt      120

ctctcttgtg cagtatctgg cttcacgttc tccaactacg gtatggtgtg ggttcgtcag      180

gctccaggta aaggtctgga atgggtggcg tatattgact ccgacggcga caacacctac      240

tatcgcgact ctgtgaaagg tcgcttcacc atttcccgcg ataacgccaa atccagcctg      300

tacctgcaga tgaacagcct gcgtgctgaa gatactgcgg tgtactattg caccactggc      360

atcgtgcgtc cgtttctgta ttggggtcag ggtaccctcg ttactgtctc gagcgcttct      420

acaaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      480

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      540

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      600

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      660

tgcaacgtga atcacaagcc cagcaacacc aaggtcgaca agaaagttga gcccaaatct      720

tgtgacaaaa ctcacacatg cgccgcg                                          747


<210>  41
<211>  247
<212>  PRT
<213>  Artificial

<220>
<223>  1519 gH20 Fab' heavy chain with signal sequence (mammalian expression)

<400>  41

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Pro Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Tyr Ile Asp Ser Asp Gly Asp Asn Thr Tyr Tyr Arg 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Thr Gly Ile Val Arg Pro Phe Leu Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Ala Ala 
                245         


<210>  42
<211>  741
<212>  DNA
<213>  Artificial

<220>
<223>  1519 gH20 Fab' heavy chain with signal sequence (mammalian expression)

<400>  42
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa ctacaggagt ccattctgag       60

gtaccacttg tggaaagcgg aggaggtctt gtgcagcctg gaggaagttt acgtctctct      120

tgtgctgtgt ctggcttcac cttctccaat tacggaatgg tctgggtcag acaagcacct      180

ggaaagggtc ttgaatgggt ggcctatatt gactctgacg gggacaacac ctactatcgg      240

gattccgtga aaggacgctt cacaatctcc cgagataacg ccaagagctc actgtacctg      300

cagatgaata gcctgagagc cgaggatact gccgtgtact attgcacaac gggaatcgtt      360

aggccttttc tgtactgggg acagggcacc ttggttactg tctcgagcgc ttctacaaag      420

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      480

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      540

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      600

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      660

gtgaatcaca agcccagcaa caccaaggtc gacaagaaag ttgagcccaa atcttgtgac      720

aaaactcaca catgcgccgc g                                                741


<210>  43
<211>  444
<212>  PRT
<213>  Artificial

<220>
<223>  1519gH20 IgG4 heavy chain (V + human gamma-4P constant)

<400>  43

Glu Val Pro Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asp Ser Asp Gly Asp Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Gly Ile Val Arg Pro Phe Leu Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 


<210>  44
<211>  1939
<212>  DNA
<213>  Artificial

<220>
<223>  1519gH20 IgG4 heavy chain (V + human gamma-4P constant with exons)

<400>  44
gaggtaccac ttgtggaaag cggaggaggt cttgtgcagc ctggaggaag tttacgtctc       60

tcttgtgctg tgtctggctt caccttctcc aattacggaa tggtctgggt cagacaagca      120

cctggaaagg gtcttgaatg ggtggcctat attgactctg acggggacaa cacctactat      180

cgggattccg tgaaaggacg cttcacaatc tcccgagata acgccaagag ctcactgtac      240

ctgcagatga atagcctgag agccgaggat actgccgtgt actattgcac aacgggaatc      300

gttaggcctt ttctgtactg gggacagggc accttggtta ctgtctcgag cgcttctaca      360

aagggcccat ccgtcttccc cctggcgccc tgctccagga gcacctccga gagcacagcc      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacgaagac ctacacctgc      600

aacgtagatc acaagcccag caacaccaag gtggacaaga gagttggtga gaggccagca      660

cagggaggga gggtgtctgc tggaagccag gctcagccct cctgcctgga cgcaccccgg      720

ctgtgcagcc ccagcccagg gcagcaaggc atgccccatc tgtctcctca cccggaggcc      780

tctgaccacc ccactcatgc ccagggagag ggtcttctgg atttttccac caggctccgg      840

gcagccacag gctggatgcc cctaccccag gccctgcgca tacaggggca ggtgctgcgc      900

tcagacctgc caagagccat atccgggagg accctgcccc tgacctaagc ccaccccaaa      960

ggccaaactc tccactccct cagctcagac accttctctc ctcccagatc tgagtaactc     1020

ccaatcttct ctctgcagag tccaaatatg gtcccccatg cccaccatgc ccaggtaagc     1080

caacccaggc ctcgccctcc agctcaaggc gggacaggtg ccctagagta gcctgcatcc     1140

agggacaggc cccagccggg tgctgacgca tccacctcca tctcttcctc agcacctgag     1200

ttcctggggg gaccatcagt cttcctgttc cccccaaaac ccaaggacac tctcatgatc     1260

tcccggaccc ctgaggtcac gtgcgtggtg gtggacgtga gccaggaaga ccccgaggtc     1320

cagttcaact ggtacgtgga tggcgtggag gtgcataatg ccaagacaaa gccgcgggag     1380

gagcagttca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1440

ctgaacggca aggagtacaa gtgcaaggtc tccaacaaag gcctcccgtc ctccatcgag     1500

aaaaccatct ccaaagccaa aggtgggacc cacggggtgc gagggccaca tggacagagg     1560

tcagctcggc ccaccctctg ccctgggagt gaccgctgtg ccaacctctg tccctacagg     1620

gcagccccga gagccacagg tgtacaccct gcccccatcc caggaggaga tgaccaagaa     1680

ccaggtcagc ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg     1740

ggagagcaat gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga     1800

cggctccttc ttcctctaca gcaggctaac cgtggacaag agcaggtggc aggaggggaa     1860

tgtcttctca tgctccgtga tgcatgaggc tctgcacaac cactacacac agaagagcct     1920

ctccctgtct ctgggtaaa                                                  1939


<210>  45
<211>  1996
<212>  DNA
<213>  Artificial

<220>
<223>  1519gH20 IgG4 heavy chain (V + human gamma-4P constant) with 
       signal sequence

<400>  45
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa ctacaggagt ccattctgag       60

gtaccacttg tggaaagcgg aggaggtctt gtgcagcctg gaggaagttt acgtctctct      120

tgtgctgtgt ctggcttcac cttctccaat tacggaatgg tctgggtcag acaagcacct      180

ggaaagggtc ttgaatgggt ggcctatatt gactctgacg gggacaacac ctactatcgg      240

gattccgtga aaggacgctt cacaatctcc cgagataacg ccaagagctc actgtacctg      300

cagatgaata gcctgagagc cgaggatact gccgtgtact attgcacaac gggaatcgtt      360

aggccttttc tgtactgggg acagggcacc ttggttactg tctcgagcgc ttctacaaag      420

ggcccatccg tcttccccct ggcgccctgc tccaggagca cctccgagag cacagccgcc      480

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      540

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      600

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cgaagaccta cacctgcaac      660

gtagatcaca agcccagcaa caccaaggtg gacaagagag ttggtgagag gccagcacag      720

ggagggaggg tgtctgctgg aagccaggct cagccctcct gcctggacgc accccggctg      780

tgcagcccca gcccagggca gcaaggcatg ccccatctgt ctcctcaccc ggaggcctct      840

gaccacccca ctcatgccca gggagagggt cttctggatt tttccaccag gctccgggca      900

gccacaggct ggatgcccct accccaggcc ctgcgcatac aggggcaggt gctgcgctca      960

gacctgccaa gagccatatc cgggaggacc ctgcccctga cctaagccca ccccaaaggc     1020

caaactctcc actccctcag ctcagacacc ttctctcctc ccagatctga gtaactccca     1080

atcttctctc tgcagagtcc aaatatggtc ccccatgccc accatgccca ggtaagccaa     1140

cccaggcctc gccctccagc tcaaggcggg acaggtgccc tagagtagcc tgcatccagg     1200

gacaggcccc agccgggtgc tgacgcatcc acctccatct cttcctcagc acctgagttc     1260

ctggggggac catcagtctt cctgttcccc ccaaaaccca aggacactct catgatctcc     1320

cggacccctg aggtcacgtg cgtggtggtg gacgtgagcc aggaagaccc cgaggtccag     1380

ttcaactggt acgtggatgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag     1440

cagttcaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     1500

aacggcaagg agtacaagtg caaggtctcc aacaaaggcc tcccgtcctc catcgagaaa     1560

accatctcca aagccaaagg tgggacccac ggggtgcgag ggccacatgg acagaggtca     1620

gctcggccca ccctctgccc tgggagtgac cgctgtgcca acctctgtcc ctacagggca     1680

gccccgagag ccacaggtgt acaccctgcc cccatcccag gaggagatga ccaagaacca     1740

ggtcagcctg acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga     1800

gagcaatggg cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg     1860

ctccttcttc ctctacagca ggctaaccgt ggacaagagc aggtggcagg aggggaatgt     1920

cttctcatgc tccgtgatgc atgaggctct gcacaaccac tacacacaga agagcctctc     1980

cctgtctctg ggtaaa                                                     1996


<210>  46
<211>  347
<212>  PRT
<213>  Artificial

<220>
<223>  1519gL20 FabFv light chain

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Val Gly Ala 
            20                  25                  30          


Ser Gly Lys Thr Tyr Leu Tyr Trp Leu Phe Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Thr Leu Asp Ser Gly Ile Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr His Phe Pro His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
225                 230                 235                 240 


Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                245                 250                 255     


Thr Cys Gln Ser Ser Pro Ser Val Trp Ser Asn Phe Leu Ser Trp Tyr 
            260                 265                 270         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser 
        275                 280                 285             


Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    290                 295                 300                 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
305                 310                 315                 320 


Thr Tyr Tyr Cys Gly Gly Gly Tyr Ser Ser Ile Ser Asp Thr Thr Phe 
                325                 330                 335     


Gly Cys Gly Thr Lys Val Glu Ile Lys Arg Thr 
            340                 345         


<210>  47
<211>  1041
<212>  DNA
<213>  Artificial

<220>
<223>  1519gL20 FabFv light chain

<400>  47
gatatccaga tgacccagag cccatctagc ttatccgctt ccgttggtga tcgcgtgaca       60

attacgtgta agagctccca atctctcgtg ggtgcaagtg gcaagaccta tctgtactgg      120

ctctttcaga agcctggcaa ggcaccaaaa cggctgatct atctggtgtc tacccttgac      180

tctgggatac cgtcacgatt ttccggatct gggagcggaa ctgagttcac actcacgatt      240

tcatcgctgc aacccgagga ctttgctacc tactactgcc tgcaaggcac tcatttccct      300

cacactttcg gccaggggac aaaactcgaa atcaaacgta cggtagcggc cccatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctg      540

agcagcaccc tgacgctgtc taaagcagac tacgagaaac acaaagtgta cgcctgcgaa      600

gtcacccatc agggcctgag ctcaccagta acaaaaagtt ttaatagagg ggagtgtagc      660

ggtggcggtg gcagtggtgg gggaggctcc ggaggtggcg gttcagacat acaaatgacc      720

cagagtcctt catcggtatc cgcgtccgtt ggcgataggg tgactattac atgtcaaagc      780

tctcctagcg tctggagcaa ttttctatcc tggtatcaac agaaaccggg gaaggctcca      840

aaacttctga tttatgaagc ctcgaaactc accagtggag ttccgtcaag attcagtggc      900

tctggatcag ggacagactt cacgttgaca atcagttcgc tgcaaccaga ggactttgcg      960

acctactatt gtggtggagg ttacagtagc ataagtgata cgacatttgg gtgcggtact     1020

aaggtggaaa tcaaacgtac c                                               1041


<210>  48
<211>  367
<212>  PRT
<213>  Artificial

<220>
<223>  1519gL20 FabFv light chain with signal sequence

<400>  48

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Val Gly Ala Ser Gly Lys Thr Tyr Leu Tyr Trp Leu Phe Gln Lys 
    50                  55                  60                  


Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr Leu Val Ser Thr Leu Asp 
65                  70                  75                  80  


Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Gly Thr His Phe Pro His Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                245                 250                 255     


Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp 
            260                 265                 270         


Arg Val Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Trp Ser Asn Phe 
        275                 280                 285             


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
    290                 295                 300                 


Tyr Glu Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 
305                 310                 315                 320 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
                325                 330                 335     


Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gly Gly Tyr Ser Ser Ile Ser 
            340                 345                 350         


Asp Thr Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Arg Thr 
        355                 360                 365         


<210>  49
<211>  1101
<212>  DNA
<213>  Artificial

<220>
<223>  1519gL20 FabFv light chain with signal sequence

<400>  49
atgtctgtcc ccacccaagt cctcggactc ctgctactct ggcttacaga tgccagatgc       60

gatatccaga tgacccagag cccatctagc ttatccgctt ccgttggtga tcgcgtgaca      120

attacgtgta agagctccca atctctcgtg ggtgcaagtg gcaagaccta tctgtactgg      180

ctctttcaga agcctggcaa ggcaccaaaa cggctgatct atctggtgtc tacccttgac      240

tctgggatac cgtcacgatt ttccggatct gggagcggaa ctgagttcac actcacgatt      300

tcatcgctgc aacccgagga ctttgctacc tactactgcc tgcaaggcac tcatttccct      360

cacactttcg gccaggggac aaaactcgaa atcaaacgta cggtagcggc cccatctgtc      420

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      480

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      540

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctg      600

agcagcaccc tgacgctgtc taaagcagac tacgagaaac acaaagtgta cgcctgcgaa      660

gtcacccatc agggcctgag ctcaccagta acaaaaagtt ttaatagagg ggagtgtagc      720

ggtggcggtg gcagtggtgg gggaggctcc ggaggtggcg gttcagacat acaaatgacc      780

cagagtcctt catcggtatc cgcgtccgtt ggcgataggg tgactattac atgtcaaagc      840

tctcctagcg tctggagcaa ttttctatcc tggtatcaac agaaaccggg gaaggctcca      900

aaacttctga tttatgaagc ctcgaaactc accagtggag ttccgtcaag attcagtggc      960

tctggatcag ggacagactt cacgttgaca atcagttcgc tgcaaccaga ggactttgcg     1020

acctactatt gtggtggagg ttacagtagc ataagtgata cgacatttgg gtgcggtact     1080

aaggtggaaa tcaaacgtac c                                               1101


<210>  50
<211>  357
<212>  PRT
<213>  Artificial

<220>
<223>  1519gH20 FabFv heavy chain

<400>  50

Glu Val Pro Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asp Ser Asp Gly Asp Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Gly Ile Val Arg Pro Phe Leu Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Thr Gly Gly Gly Gly Ser Glu Val Gln Leu 
225                 230                 235                 240 


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                245                 250                 255     


Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr Ala Ile Asn Trp 
            260                 265                 270         


Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Ile Ile Trp 
        275                 280                 285             


Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys Gly Arg Phe Thr 
    290                 295                 300                 


Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
305                 310                 315                 320 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Thr Val Pro 
                325                 330                 335     


Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly Gln Gly Thr Leu 
            340                 345                 350         


Val Thr Val Ser Ser 
        355         


<210>  51
<211>  1071
<212>  DNA
<213>  Artificial

<220>
<223>  1519gH20 FabFv heavy chain

<400>  51
gaggtaccac ttgtggaaag cggaggaggt cttgtgcagc ctggaggaag tttacgtctc       60

tcttgtgctg tgtctggctt caccttctcc aattacggaa tggtctgggt cagacaagca      120

cctggaaagg gtcttgaatg ggtggcctat attgactctg acggggacaa cacctactat      180

cgggattccg tgaaaggacg cttcacaatc tcccgagata acgccaagag ctcactgtac      240

ctgcagatga atagcctgag agccgaggat actgccgtgt actattgcac aacgggaatc      300

gttaggcctt ttctgtactg gggacagggc accttggtta ctgtctcgag cgcgtccaca      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccag tgacggtgtc gtggaactca      480

ggtgccctga ccagcggcgt tcacaccttc ccggctgtcc tacagtcttc aggactctac      540

tccctgagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtcgataaga aagttgagcc caaatcttgt      660

agtggaggtg ggggctcagg tggaggcggg accggtggag gtggcagcga ggttcaactg      720

cttgagtctg gaggaggcct agtccagcct ggagggagcc tgcgtctctc ttgtgcagta      780

agcggcatcg acctgagcaa ttacgccatc aactgggtga gacaagctcc ggggaagtgt      840

ttagaatgga tcggtataat atgggccagt gggacgacct tttatgctac atgggcgaaa      900

ggaaggttta caattagccg ggacaatagc aaaaacaccg tgtatctcca aatgaactcc      960

ttgcgagcag aggacacggc ggtgtactat tgtgctcgca ctgtcccagg ttatagcact     1020

gcaccctact tcgatctgtg gggacaaggg accctggtga ctgtttcaag t              1071


<210>  52
<211>  376
<212>  PRT
<213>  Artificial

<220>
<223>  1519gH20 FabFv heavy chain with signal sequence

<400>  52

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Pro Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Tyr Ile Asp Ser Asp Gly Asp Asn Thr Tyr Tyr Arg 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Thr Gly Ile Val Arg Pro Phe Leu Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Thr Gly Gly Gly Gly Ser Glu 
                245                 250                 255     


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
            260                 265                 270         


Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr Ala 
        275                 280                 285             


Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly 
    290                 295                 300                 


Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys Gly 
305                 310                 315                 320 


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
                325                 330                 335     


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            340                 345                 350         


Thr Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly Gln 
        355                 360                 365             


Gly Thr Leu Val Thr Val Ser Ser 
    370                 375     


<210>  53
<211>  1128
<212>  DNA
<213>  Artificial

<220>
<223>  1519gH20 FabFv heavy chain with signal sequence

<400>  53
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa ctacaggagt ccattctgag       60

gtaccacttg tggaaagcgg aggaggtctt gtgcagcctg gaggaagttt acgtctctct      120

tgtgctgtgt ctggcttcac cttctccaat tacggaatgg tctgggtcag acaagcacct      180

ggaaagggtc ttgaatgggt ggcctatatt gactctgacg gggacaacac ctactatcgg      240

gattccgtga aaggacgctt cacaatctcc cgagataacg ccaagagctc actgtacctg      300

cagatgaata gcctgagagc cgaggatact gccgtgtact attgcacaac gggaatcgtt      360

aggccttttc tgtactgggg acagggcacc ttggttactg tctcgagcgc gtccacaaag      420

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      480

ctgggctgcc tggtcaagga ctacttcccc gaaccagtga cggtgtcgtg gaactcaggt      540

gccctgacca gcggcgttca caccttcccg gctgtcctac agtcttcagg actctactcc      600

ctgagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      660

gtgaatcaca agcccagcaa caccaaggtc gataagaaag ttgagcccaa atcttgtagt      720

ggaggtgggg gctcaggtgg aggcgggacc ggtggaggtg gcagcgaggt tcaactgctt      780

gagtctggag gaggcctagt ccagcctgga gggagcctgc gtctctcttg tgcagtaagc      840

ggcatcgacc tgagcaatta cgccatcaac tgggtgagac aagctccggg gaagtgttta      900

gaatggatcg gtataatatg ggccagtggg acgacctttt atgctacatg ggcgaaagga      960

aggtttacaa ttagccggga caatagcaaa aacaccgtgt atctccaaat gaactccttg     1020

cgagcagagg acacggcggt gtactattgt gctcgcactg tcccaggtta tagcactgca     1080

ccctacttcg atctgtgggg acaagggacc ctggtgactg tttcaagt                  1128


<210>  54
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Human VK1 2-1-(1) A30 JK2 acceptor framework

<400>  54

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  55
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Human VK1 2-1-(1) A30 JK2 acceptor framework

<400>  55
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca      120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtctacag cataatagtt acccttacac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  56
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Human VH3 1-3 3-07 JH4 acceptor framework

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


<210>  57
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Human VH3 1-3 3-07 JH4 acceptor framework

<400>  57
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agctattgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaagcaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagatacttt      300

gactactggg gccagggaac cctggtcacc gtctcc                                336


<210>  58
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Rat Ab 1548 VL region

<400>  58

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ala Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val Gly Ala 
            20                  25                  30          


Ser Gly Lys Thr Tyr Leu Tyr Trp Leu Phe Gln Arg Ser Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Thr Leu Asp Ser Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Glu Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Arg Arg Val Glu Ala Asp Asp Leu Gly Val Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr His Phe Pro His Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  59
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Rat Ab 1548 VL region

<400>  59
gatgttgtga tgacccagac tccactgtct ttgtcggttg cccttggaca accagcctcc       60

atctcttgca agtcaagtca gagcctcgta ggtgctagtg gaaagacata tttgtattgg      120

ttatttcaga ggtccggcca gtctccaaag cgactaatct atctggtgtc cacactggac      180

tctggaattc ctgataggtt cagtggcagt ggagcagaga cagattttac tcttaaaatc      240

cgcagagtgg aagccgatga tttgggagtt tattactgct tgcaaggtac acattttcct      300

cacacgtttg gagctgggac caagctggaa ataaaa                                336


<210>  60
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Rat Ab 1548 VH region

<400>  60

Glu Val Pro Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Val Trp Val Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asp Ser Asp Gly Asp Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Gly Ile Val Arg Pro Phe Leu Tyr Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser 
        115     


<210>  61
<211>  348
<212>  DNA
<213>  Artificial

<220>
<223>  Rat Ab 1548 VH region

<400>  61
gaggtgccgc tggtggagtc tgggggcggc tcagtgcagc ctgggaggtc catgaaactc       60

tcctgtgtag tctcaggatt cactttcagt aattatggca tggtctgggt ccgccaggct      120

ccaaagaagg gtctggagtg ggtcgcatat attgattctg atggtgataa tacttactac      180

cgagattccg tgaagggccg attcactatc tccagaaata atgcaaaaag caccctatat      240

ttgcaaatgg acagtctgag gtctgaggac acggccactt attactgtac aacagggatt      300

gtccggccct ttctctattg gggccaagga gtcatggtca cagtctcg                   348


<210>  62
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Rat Ab 1644 VL region

<400>  62

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ala Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val Gly Ala 
            20                  25                  30          


Ser Gly Lys Thr Tyr Leu Tyr Trp Leu Phe Gln Arg Ser Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Thr Leu Asp Ser Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Glu Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Arg Arg Val Glu Ala Asp Asp Leu Gly Val Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr His Phe Pro His Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  63
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Rat Ab 1644 VL region

<400>  63
gatgttgtga tgacccagac tccactgtct ttgtcggttg ccattggaca accagcctcc       60

atctcttgca agtcaagtca gagcctcgta ggtgctagtg gaaagacata tttgtattgg      120

ttatttcaga ggtccggcca gtctccaaag cgactaatct atctggtgtc cacactggac      180

tctggaattc ctgataggtt cagtggcagt ggagcagaga cagattttac tcttaaaatc      240

cgcagagtgg aagccgatga tttgggagtt tattactgct tgcaaggtac acattttcct      300

cacacgtttg gagctgggac caagctggaa ctgaaa                                336


<210>  64
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Rat Ab 1644 VH region

<400>  64

Glu Val Pro Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Thr Lys Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Val Trp Val Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Gly Ser Asp Gly Asp Asn Ile Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Gly Ile Val Arg Pro Phe Leu Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser 
        115     


<210>  65
<211>  348
<212>  DNA
<213>  Artificial

<220>
<223>  Rat Ab 1644 VH region

<400>  65
gaggtgccgc tggtggagtc tgggggcggc tcagtgcagc ctgggaggtc cacgaaactc       60

tcctgtgtag tctcaggatt cactttcagt aactatggca tggtctgggt ccgccaggct      120

ccaaagaagg gtctggagtg ggtcgcatat attggttctg atggtgataa tatttactac      180

cgagattccg tgaagggtcg attcactatc tccagaaata atgcaaaaag caccctatat      240

ttgcaaatgg acagtctgag gtctgaggac acggccactt attactgtac aacagggatt      300

gtccggccct ttctctactg gggccaagga accacggtca ccgtctcg                   348


<210>  66
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Rat Ab 1496 VK region

<400>  66

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ala Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val Gly Ala 
            20                  25                  30          


Ser Gly Lys Thr Tyr Leu Tyr Trp Leu Phe Gln Arg Ser Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Thr Leu Asp Ser Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Glu Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Arg Arg Val Glu Ala Asp Asp Leu Gly Val Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr His Phe Pro His Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  67
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Rat Ab 1496 VK region

<400>  67
gatgttgtga tgacccagac tccactgtct ttgtcggttg cccttggaca accagcctcc       60

atctcttgca agtcaagtca gagcctcgta ggtgctagtg gaaagacata tttgtattgg      120

ttatttcaga ggtccggcca gtctccaaag cgactaatct atctggtgtc cacactggac      180

tctggaattc ctgataggtt cagtggcagt ggagcagaga cagattttac tcttaaaatc      240

cgcagagtgg aagccgatga tttgggagtt tattactgct tgcaaggtac acattttcct      300

cacacgtttg gagctgggac caagctggaa ctgaaa                                336


<210>  68
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Rat Ab 1496 VH region

<400>  68

Glu Val Leu Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Val Trp Val Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asp Ser Asp Gly Asp Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Gly Ile Val Arg Pro Phe Leu Tyr Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser 
        115     


<210>  69
<211>  348
<212>  DNA
<213>  Artificial

<220>
<223>  Rat Ab 1496 VH region

<400>  69
gaggtgctgc tggtggagtc tgggggcggc tcagtgcagc ctgggaggtc catgaaactc       60

tcctgtgtag tctcaggatt cactttcagt aattatggca tggtctgggt ccgccaggct      120

ccaaagaagg gtctggagtg ggtcgcatat attgattctg atggtgataa tacttactac      180

cgagattccg tgaagggccg attcactatc tccagaaata atgcaaaaag caccctatat      240

ttgcaaatgg acagtctgag gtctgaggac acggccactt attactgtac aacagggatt      300

gtccggccct ttctctattg gggccaagga accatggtca ccgtctcg                   348


<210>  70
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  framework

<400>  70

Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
1               5                   10                  


<210>  71
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  framework

<400>  71

Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10          


<210>  72
<211>  447
<212>  PRT
<213>  Artificial

<220>
<223>  1519gH20 IgG1 heavy chain (V + human gamma-1 constant)

<400>  72

Glu Val Pro Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asp Ser Asp Gly Asp Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Gly Ile Val Arg Pro Phe Leu Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  73
<211>  1947
<212>  DNA
<213>  Artificial

<220>
<223>  1519gH20 IgG1 heavy chain (V + human gamma-1 constant with exons)

<400>  73
gaggtaccac ttgtggaaag cggaggaggt cttgtgcagc ctggaggaag tttacgtctc       60

tcttgtgctg tgtctggctt caccttctcc aattacggaa tggtctgggt cagacaagca      120

cctggaaagg gtcttgaatg ggtggcctat attgactctg acggggacaa cacctactat      180

cgggattccg tgaaaggacg cttcacaatc tcccgagata acgccaagag ctcactgtac      240

ctgcagatga atagcctgag agccgaggat actgccgtgt actattgcac aacgggaatc      300

gttaggcctt ttctgtactg gggacagggc accttggtta ctgtctcgag cgcttctaca      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtcgacaaga aagttggtga gaggccagca      660

cagggaggga gggtgtctgc tggaagccag gctcagcgct cctgcctgga cgcatcccgg      720

ctatgcagcc ccagtccagg gcagcaaggc aggccccgtc tgcctcttca cccggaggcc      780

tctgcccgcc ccactcatgc tcagggagag ggtcttctgg ctttttcccc aggctctggg      840

caggcacagg ctaggtgccc ctaacccagg ccctgcacac aaaggggcag gtgctgggct      900

cagacctgcc aagagccata tccgggagga ccctgcccct gacctaagcc caccccaaag      960

gccaaactct ccactccctc agctcggaca ccttctctcc tcccagatct gagtaactcc     1020

caatcttctc tctgcagagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc     1080

aggtaagcca gcccaggcct cgccctccag ctcaaggcgg gacaggtgcc ctagagtagc     1140

ctgcatccag ggacaggccc cagccgggtg ctgacacgtc cacctccatc tcttcctcag     1200

cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc     1260

tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc     1320

ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc aagacaaagc     1380

cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc     1440

aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc ctcccagccc     1500

ccatcgagaa aaccatctcc aaagccaaag gtgggacccg tggggtgcga gggccacatg     1560

gacagaggcc ggctcggccc accctctgcc ctgagagtga ccgctgtacc aacctctgtc     1620

cctacagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1680

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1740

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1800

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1860

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1920

aagagcctct ccctgtctcc gggtaaa                                         1947


<210>  74
<211>  2004
<212>  DNA
<213>  Artificial

<220>
<223>  1519gH20 IgG1 heavy chain (V + human gamma-1 constant) with 
       signal sequence

<400>  74
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa ctacaggagt ccattctgag       60

gtaccacttg tggaaagcgg aggaggtctt gtgcagcctg gaggaagttt acgtctctct      120

tgtgctgtgt ctggcttcac cttctccaat tacggaatgg tctgggtcag acaagcacct      180

ggaaagggtc ttgaatgggt ggcctatatt gactctgacg gggacaacac ctactatcgg      240

gattccgtga aaggacgctt cacaatctcc cgagataacg ccaagagctc actgtacctg      300

cagatgaata gcctgagagc cgaggatact gccgtgtact attgcacaac gggaatcgtt      360

aggccttttc tgtactgggg acagggcacc ttggttactg tctcgagcgc ttctacaaag      420

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      480

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      540

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      600

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      660

gtgaatcaca agcccagcaa caccaaggtc gacaagaaag ttggtgagag gccagcacag      720

ggagggaggg tgtctgctgg aagccaggct cagcgctcct gcctggacgc atcccggcta      780

tgcagcccca gtccagggca gcaaggcagg ccccgtctgc ctcttcaccc ggaggcctct      840

gcccgcccca ctcatgctca gggagagggt cttctggctt tttccccagg ctctgggcag      900

gcacaggcta ggtgccccta acccaggccc tgcacacaaa ggggcaggtg ctgggctcag      960

acctgccaag agccatatcc gggaggaccc tgcccctgac ctaagcccac cccaaaggcc     1020

aaactctcca ctccctcagc tcggacacct tctctcctcc cagatctgag taactcccaa     1080

tcttctctct gcagagccca aatcttgtga caaaactcac acatgcccac cgtgcccagg     1140

taagccagcc caggcctcgc cctccagctc aaggcgggac aggtgcccta gagtagcctg     1200

catccaggga caggccccag ccgggtgctg acacgtccac ctccatctct tcctcagcac     1260

ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag gacaccctca     1320

tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac gaagaccctg     1380

aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag acaaagccgc     1440

gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg     1500

actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc ccagccccca     1560

tcgagaaaac catctccaaa gccaaaggtg ggacccgtgg ggtgcgaggg ccacatggac     1620

agaggccggc tcggcccacc ctctgccctg agagtgaccg ctgtaccaac ctctgtccct     1680

acagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1740

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1800

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1860

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1920

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1980

agcctctccc tgtctccggg taaa                                            2004


<210>  75
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  1519 gL20 light chain (V + constant, mammalian expression 
       alternative)

<400>  75
gatatccaga tgacccagag cccatctagc ttatccgctt ccgttggtga tcgcgtgaca       60

attacgtgta agagctccca atctctcgtg ggtgcaagtg gcaagaccta tctgtactgg      120

ctctttcaga agcctggcaa ggcaccaaaa cggctgatct atctggtgtc tacccttgac      180

tctgggatac cgtcacgatt ttccggatct gggagcggaa ctgagttcac actcacgatt      240

tcatcgctgc aacccgagga ctttgctacc tactactgcc tgcaaggcac tcatttccct      300

cacactttcg gccaggggac aaaactcgaa atcaaacgta cggtagcggc cccatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  76
<211>  684
<212>  DNA
<213>  Artificial

<220>
<223>  1519gH20 Fab' heavy chain (V + human gamma-1 CH1 + hinge, 
       mammalian expression one base change from SEQ ID NO: 38)

<400>  76
gaggtaccac ttgtggaaag cggaggaggt cttgtgcagc ctggaggaag tttacgtctc       60

tcttgtgctg tgtctggctt caccttctcc aattacggaa tggtctgggt cagacaagca      120

cctggaaagg gtcttgaatg ggtggcctat attgactctg acggggacaa cacctactat      180

cgggattccg tgaaaggacg cttcacaatc tcccgagata acgccaagag ctcactgtac      240

ctgcagatga atagcctgag agccgaggat actgccgtgt actattgcac aacgggaatc      300

gttaggcctt ttctgtactg gggacagggc accttggtta ctgtctcgag cgcttctaca      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgcgc cgcg                                             684


<210>  77
<211>  741
<212>  DNA
<213>  Artificial

<220>
<223>  1519 gH20 Fab' heavy chain with signal sequence (mammalian expression
       one base changed from SEQ ID NO: 42)

<400>  77
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa ctacaggagt ccattctgag       60

gtaccacttg tggaaagcgg aggaggtctt gtgcagcctg gaggaagttt acgtctctct      120

tgtgctgtgt ctggcttcac cttctccaat tacggaatgg tctgggtcag acaagcacct      180

ggaaagggtc ttgaatgggt ggcctatatt gactctgacg gggacaacac ctactatcgg      240

gattccgtga aaggacgctt cacaatctcc cgagataacg ccaagagctc actgtacctg      300

cagatgaata gcctgagagc cgaggatact gccgtgtact attgcacaac gggaatcgtt      360

aggccttttc tgtactgggg acagggcacc ttggttactg tctcgagcgc ttctacaaag      420

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      480

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      540

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      600

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      660

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac      720

aaaactcaca catgcgccgc g                                                741


<210>  78
<211>  346
<212>  PRT
<213>  Artificial

<220>
<223>  1519gL20 FabFv light chain (alternative sequence to SEQ ID NO: 
       46)

<400>  78

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Val Gly Ala 
            20                  25                  30          


Ser Gly Lys Thr Tyr Leu Tyr Trp Leu Phe Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Thr Leu Asp Ser Gly Ile Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr His Phe Pro His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
225                 230                 235                 240 


Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                245                 250                 255     


Cys Gln Ser Ser Pro Ser Val Trp Ser Asn Phe Leu Ser Trp Tyr Gln 
            260                 265                 270         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Lys 
        275                 280                 285             


Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    290                 295                 300                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
305                 310                 315                 320 


Tyr Tyr Cys Gly Gly Gly Tyr Ser Ser Ile Ser Asp Thr Thr Phe Gly 
                325                 330                 335     


Cys Gly Thr Lys Val Glu Ile Lys Arg Thr 
            340                 345     


<210>  79
<211>  1038
<212>  DNA
<213>  Artificial

<220>
<223>  1519gL20 FabFv light chain (alternative sequence to SEQ ID NO: 
       47)

<400>  79
gacatccaga tgacccagtc cccctccagc ctgtccgcct ccgtgggcga cagagtgacc       60

atcacatgca agtcctccca gtccctggtc ggagcctccg gcaagaccta cctgtactgg      120

ctgttccaga agcccggcaa ggcccccaag cggctgatct acctggtgtc taccctggac      180

tccggcatcc cctcccggtt ctccggctct ggctctggca ccgagttcac cctgaccatc      240

tccagcctgc agcccgagga cttcgccacc tactactgtc tgcaaggcac ccacttcccc      300

cacaccttcg gccagggcac caagctggaa atcaagcgga ccgtagcggc cccatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgtggt      660

ggaggtggct ctggcggtgg tggctccgga ggcggaggaa gcgacatcca gatgacccag      720

agcccttcct ctgtaagcgc cagtgtcgga gacagagtga ctattacctg ccaaagctcc      780

ccttcagtct ggtccaattt tctatcctgg tatcagcaaa agcccggaaa ggctcctaaa      840

ttgctgatct acgaagcaag caaactcacc agcggcgtgc ccagcaggtt cagcggcagt      900

gggtctggaa ctgactttac cctgacaatc tcctcactcc agcccgagga cttcgccacc      960

tattactgcg gtggaggtta cagtagcata agtgatacga catttggatg cggcactaaa     1020

gtggaaatca agcgtacc                                                   1038


<210>  80
<211>  1071
<212>  DNA
<213>  Artificial

<220>
<223>  1519gH20 FabFv heavy chain (alternative sequence to SEQ ID NO: 
       51)

<400>  80
gaggtgcccc tggtggaatc tggcggcgga ctggtgcagc ctggcggctc cctgagactg       60

tcttgcgccg tgtccggctt caccttctcc aactacggca tggtctgggt ccgacaggct      120

cctggcaagg gactggaatg ggtggcctac atcgactccg acggcgacaa cacctactac      180

cgggactccg tgaagggccg gttcaccatc tcccgggaca acgccaagtc ctccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgcac caccggcatc      300

gtgcggccct ttctgtactg gggccagggc accctggtca ccgtgtcctc tgcttctaca      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc tggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

tccggaggtg gcggttccgg aggtggcggt acaggtggcg gtgggtccga agtccagctg      720

cttgaatccg gaggcggact cgtgcagccc ggaggcagtc ttcgcttgtc ctgcgctgta      780

tctggaatcg acctgagcaa ttacgccatc aactgggtga gacaggcacc tgggaaatgc      840

ctcgaatgga tcggcattat atgggctagt gggacgacct tttatgctac atgggcgaag      900

ggtagattca caatctcacg ggataatagt aagaacacag tgtacctgca gatgaactcc      960

ctgcgagcag aggataccgc cgtttactat tgtgctcgca ctgtcccagg ttatagcact     1020

gcaccctact ttgatctgtg ggggcagggc actctggtca ccgtctcgtc c              1071


<210>  81
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Rat Ab 1548 VL region (alternative sequence to SEQ ID NO: 58)

<400>  81

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ala Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Ser Lys Ser Ser Gln Ser Leu Val Gly Ala 
            20                  25                  30          


Gly Gly Lys Thr Tyr Leu Tyr Trp Leu Leu Gln Arg Ser Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Thr Leu Asp Ser Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Glu Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Arg Arg Val Glu Ala Asp Asp Leu Gly Val Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr His Phe Pro His Thr Phe Gly Ala Gly Thr Asn Leu Glu Ile Lys 
            100                 105                 110         


<210>  82
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Rat Ab 1548 VL region (alternative sequence to SEQ ID NO: 59)

<400>  82
gatgttgtga tgacccagac tccactgtct ttgtcggttg ccattggaca accagcctcc       60

atctcttcta agtcaagtca gagcctcgta ggtgctggtg gaaagacata tttgtattgg      120

ttattacaga ggtccggcca gtctccaaag cgactaatct atctggtgtc cacactggac      180

tctggaattc ctgataggtt cagtggcagt ggagcagaga cagattttac tcttaaaatc      240

cgcagagtgg aagccgatga tttgggagtt tattactgct tgcaaggtac acattttcct      300

cacacgtttg gagctgggac caacctggaa ataaaa                                336


<210>  83
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Rat Ab 1548 VH region (alternative sequence to SEQ ID NO: 60)

<400>  83

Glu Val Pro Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Val Trp Val Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Gly Ser Asp Gly Asp Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Gly Ile Val Arg Pro Phe Leu Tyr Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser 
        115     


<210>  84
<211>  348
<212>  DNA
<213>  Artificial

<220>
<223>  Rat Ab 1548 VH region (alternative sequence to SEQ IS NO: 61)

<400>  84
gaggtgccgc tggtggagtc tgggggcggc tcagtgcagc ctgggaggtc catgaaactc       60

tcctgtgtag tctcaggatt cactttcagt aactatggca tggtctgggt ccgccaggct      120

ccaaagaagg gtctggagtg ggtcgcatat attggttctg atggtgataa tacttactac      180

cgagattccg tgaagggccg attcactatc tccagaaata atgcaaaaag caccctatat      240

ttgcaaatgg acagtctgag gtctgaggac acggccactt attactgtac aacagggatt      300

gtccggccct ttctctactg gggccaagga gtcatggtca cagtctcg                   348


<210>  85
<211>  1947
<212>  DNA
<213>  Artificial

<220>
<223>  1519gH20 IgG1 heavy chain (V + human gamma-1 constant with exons 
       one base change to SEQ ID NO: 71)

<400>  85
gaggtaccac ttgtggaaag cggaggaggt cttgtgcagc ctggaggaag tttacgtctc       60

tcttgtgctg tgtctggctt caccttctcc aattacggaa tggtctgggt cagacaagca      120

cctggaaagg gtcttgaatg ggtggcctat attgactctg acggggacaa cacctactat      180

cgggattccg tgaaaggacg cttcacaatc tcccgagata acgccaagag ctcactgtac      240

ctgcagatga atagcctgag agccgaggat actgccgtgt actattgcac aacgggaatc      300

gttaggcctt ttctgtactg gggacagggc accttggtta ctgtctcgag cgcttctaca      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttggtga gaggccagca      660

cagggaggga gggtgtctgc tggaagccag gctcagcgct cctgcctgga cgcatcccgg      720

ctatgcagcc ccagtccagg gcagcaaggc aggccccgtc tgcctcttca cccggaggcc      780

tctgcccgcc ccactcatgc tcagggagag ggtcttctgg ctttttcccc aggctctggg      840

caggcacagg ctaggtgccc ctaacccagg ccctgcacac aaaggggcag gtgctgggct      900

cagacctgcc aagagccata tccgggagga ccctgcccct gacctaagcc caccccaaag      960

gccaaactct ccactccctc agctcggaca ccttctctcc tcccagatct gagtaactcc     1020

caatcttctc tctgcagagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc     1080

aggtaagcca gcccaggcct cgccctccag ctcaaggcgg gacaggtgcc ctagagtagc     1140

ctgcatccag ggacaggccc cagccgggtg ctgacacgtc cacctccatc tcttcctcag     1200

cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc     1260

tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc     1320

ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc aagacaaagc     1380

cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc     1440

aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc ctcccagccc     1500

ccatcgagaa aaccatctcc aaagccaaag gtgggacccg tggggtgcga gggccacatg     1560

gacagaggcc ggctcggccc accctctgcc ctgagagtga ccgctgtacc aacctctgtc     1620

cctacagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1680

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1740

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1800

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1860

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1920

aagagcctct ccctgtctcc gggtaaa                                         1947


<210>  86
<211>  2004
<212>  DNA
<213>  Artificial

<220>
<223>  1519gH20 IgG1 heavy chain (V + human gamma-1 constant) with 
       signal sequence (one base change from SEQ ID NO:72)

<400>  86
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa ctacaggagt ccattctgag       60

gtaccacttg tggaaagcgg aggaggtctt gtgcagcctg gaggaagttt acgtctctct      120

tgtgctgtgt ctggcttcac cttctccaat tacggaatgg tctgggtcag acaagcacct      180

ggaaagggtc ttgaatgggt ggcctatatt gactctgacg gggacaacac ctactatcgg      240

gattccgtga aaggacgctt cacaatctcc cgagataacg ccaagagctc actgtacctg      300

cagatgaata gcctgagagc cgaggatact gccgtgtact attgcacaac gggaatcgtt      360

aggccttttc tgtactgggg acagggcacc ttggttactg tctcgagcgc ttctacaaag      420

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      480

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      540

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      600

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      660

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttggtgagag gccagcacag      720

ggagggaggg tgtctgctgg aagccaggct cagcgctcct gcctggacgc atcccggcta      780

tgcagcccca gtccagggca gcaaggcagg ccccgtctgc ctcttcaccc ggaggcctct      840

gcccgcccca ctcatgctca gggagagggt cttctggctt tttccccagg ctctgggcag      900

gcacaggcta ggtgccccta acccaggccc tgcacacaaa ggggcaggtg ctgggctcag      960

acctgccaag agccatatcc gggaggaccc tgcccctgac ctaagcccac cccaaaggcc     1020

aaactctcca ctccctcagc tcggacacct tctctcctcc cagatctgag taactcccaa     1080

tcttctctct gcagagccca aatcttgtga caaaactcac acatgcccac cgtgcccagg     1140

taagccagcc caggcctcgc cctccagctc aaggcgggac aggtgcccta gagtagcctg     1200

catccaggga caggccccag ccgggtgctg acacgtccac ctccatctct tcctcagcac     1260

ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag gacaccctca     1320

tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac gaagaccctg     1380

aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag acaaagccgc     1440

gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg     1500

actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc ccagccccca     1560

tcgagaaaac catctccaaa gccaaaggtg ggacccgtgg ggtgcgaggg ccacatggac     1620

agaggccggc tcggcccacc ctctgccctg agagtgaccg ctgtaccaac ctctgtccct     1680

acagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1740

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1800

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1860

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1920

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1980

agcctctccc tgtctccggg taaa                                            2004


<210>  87
<211>  444
<212>  PRT
<213>  Artificial

<220>
<223>  1519gH20 IgG4 heavy chain (V + human gamma-4 constant no P 
       mutations)

<400>  87

Glu Val Pro Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asp Ser Asp Gly Asp Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Gly Ile Val Arg Pro Phe Leu Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 


<210>  88
<211>  1939
<212>  DNA
<213>  Artificial

<220>
<223>  1519gH20 IgG4 heavy chain (V + human gamma-4 constant with exons 
       no P mutations)

<400>  88
gaggtaccac ttgtggaaag cggaggaggt cttgtgcagc ctggaggaag tttacgtctc       60

tcttgtgctg tgtctggctt caccttctcc aattacggaa tggtctgggt cagacaagca      120

cctggaaagg gtcttgaatg ggtggcctat attgactctg acggggacaa cacctactat      180

cgggattccg tgaaaggacg cttcacaatc tcccgagata acgccaagag ctcactgtac      240

ctgcagatga atagcctgag agccgaggat actgccgtgt actattgcac aacgggaatc      300

gttaggcctt ttctgtactg gggacagggc accttggtta ctgtctcgag cgcttctaca      360

aagggcccat ccgtcttccc cctggcgccc tgctccagga gcacctccga gagcacagcc      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacgaagac ctacacctgc      600

aacgtagatc acaagcccag caacaccaag gtggacaaga gagttggtga gaggccagca      660

cagggaggga gggtgtctgc tggaagccag gctcagccct cctgcctgga cgcaccccgg      720

ctgtgcagcc ccagcccagg gcagcaaggc atgccccatc tgtctcctca cccggaggcc      780

tctgaccacc ccactcatgc ccagggagag ggtcttctgg atttttccac caggctccgg      840

gcagccacag gctggatgcc cctaccccag gccctgcgca tacaggggca ggtgctgcgc      900

tcagacctgc caagagccat atccgggagg accctgcccc tgacctaagc ccaccccaaa      960

ggccaaactc tccactccct cagctcagac accttctctc ctcccagatc tgagtaactc     1020

ccaatcttct ctctgcagag tccaaatatg gtcccccatg cccatcatgc ccaggtaagc     1080

caacccaggc ctcgccctcc agctcaaggc gggacaggtg ccctagagta gcctgcatcc     1140

agggacaggc cccagccggg tgctgacgca tccacctcca tctcttcctc agcacctgag     1200

ttcctggggg gaccatcagt cttcctgttc cccccaaaac ccaaggacac tctcatgatc     1260

tcccggaccc ctgaggtcac gtgcgtggtg gtggacgtga gccaggaaga ccccgaggtc     1320

cagttcaact ggtacgtgga tggcgtggag gtgcataatg ccaagacaaa gccgcgggag     1380

gagcagttca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1440

ctgaacggca aggagtacaa gtgcaaggtc tccaacaaag gcctcccgtc ctccatcgag     1500

aaaaccatct ccaaagccaa aggtgggacc cacggggtgc gagggccaca tggacagagg     1560

tcagctcggc ccaccctctg ccctgggagt gaccgctgtg ccaacctctg tccctacagg     1620

gcagccccga gagccacagg tgtacaccct gcccccatcc caggaggaga tgaccaagaa     1680

ccaggtcagc ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg     1740

ggagagcaat gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga     1800

cggctccttc ttcctctaca gcaggctaac cgtggacaag agcaggtggc aggaggggaa     1860

tgtcttctca tgctccgtga tgcatgaggc tctgcacaac cactacacac agaagagcct     1920

ctccctgtct ctgggtaaa                                                  1939


<210>  89
<211>  1996
<212>  DNA
<213>  Artificial

<220>
<223>  1519gH20 IgG4 heavy chain (V + human gamma-4 constant) with 
       signal sequence - no P mutation

<400>  89
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa ctacaggagt ccattctgag       60

gtaccacttg tggaaagcgg aggaggtctt gtgcagcctg gaggaagttt acgtctctct      120

tgtgctgtgt ctggcttcac cttctccaat tacggaatgg tctgggtcag acaagcacct      180

ggaaagggtc ttgaatgggt ggcctatatt gactctgacg gggacaacac ctactatcgg      240

gattccgtga aaggacgctt cacaatctcc cgagataacg ccaagagctc actgtacctg      300

cagatgaata gcctgagagc cgaggatact gccgtgtact attgcacaac gggaatcgtt      360

aggccttttc tgtactgggg acagggcacc ttggttactg tctcgagcgc ttctacaaag      420

ggcccatccg tcttccccct ggcgccctgc tccaggagca cctccgagag cacagccgcc      480

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      540

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      600

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cgaagaccta cacctgcaac      660

gtagatcaca agcccagcaa caccaaggtg gacaagagag ttggtgagag gccagcacag      720

ggagggaggg tgtctgctgg aagccaggct cagccctcct gcctggacgc accccggctg      780

tgcagcccca gcccagggca gcaaggcatg ccccatctgt ctcctcaccc ggaggcctct      840

gaccacccca ctcatgccca gggagagggt cttctggatt tttccaccag gctccgggca      900

gccacaggct ggatgcccct accccaggcc ctgcgcatac aggggcaggt gctgcgctca      960

gacctgccaa gagccatatc cgggaggacc ctgcccctga cctaagccca ccccaaaggc     1020

caaactctcc actccctcag ctcagacacc ttctctcctc ccagatctga gtaactccca     1080

atcttctctc tgcagagtcc aaatatggtc ccccatgccc atcatgccca ggtaagccaa     1140

cccaggcctc gccctccagc tcaaggcggg acaggtgccc tagagtagcc tgcatccagg     1200

gacaggcccc agccgggtgc tgacgcatcc acctccatct cttcctcagc acctgagttc     1260

ctggggggac catcagtctt cctgttcccc ccaaaaccca aggacactct catgatctcc     1320

cggacccctg aggtcacgtg cgtggtggtg gacgtgagcc aggaagaccc cgaggtccag     1380

ttcaactggt acgtggatgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag     1440

cagttcaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     1500

aacggcaagg agtacaagtg caaggtctcc aacaaaggcc tcccgtcctc catcgagaaa     1560

accatctcca aagccaaagg tgggacccac ggggtgcgag ggccacatgg acagaggtca     1620

gctcggccca ccctctgccc tgggagtgac cgctgtgcca acctctgtcc ctacagggca     1680

gccccgagag ccacaggtgt acaccctgcc cccatcccag gaggagatga ccaagaacca     1740

ggtcagcctg acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga     1800

gagcaatggg cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg     1860

ctccttcttc ctctacagca ggctaaccgt ggacaagagc aggtggcagg aggggaatgt     1920

cttctcatgc tccgtgatgc atgaggctct gcacaaccac tacacacaga agagcctctc     1980

cctgtctctg ggtaaa                                                     1996


<210>  90
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  1519 gL20 V-region (mammalian expression alternative to SEQ ID NO:
       17)

<400>  90
gacatccaga tgacccagtc cccctccagc ctgtccgcct ccgtgggcga cagagtgacc       60

atcacatgca agtcctccca gtccctggtc ggagcctccg gcaagaccta cctgtactgg      120

ctgttccaga agcccggcaa ggcccccaag cggctgatct acctggtgtc taccctggac      180

tccggcatcc cctcccggtt ctccggctct ggctctggca ccgagttcac cctgaccatc      240

tccagcctgc agcccgagga cttcgccacc tactactgtc tgcaaggcac ccacttcccc      300

cacaccttcg gccagggcac caagctggaa atcaag                                336



<210>  91
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  1519 gL20 light chain (V + constant, mammalian expression) 
       alternative to SEQ ID NO: 24)

<400>  91
gacatccaga tgacccagtc cccctccagc ctgtccgcct ccgtgggcga cagagtgacc       60

atcacatgca agtcctccca gtccctggtc ggagcctccg gcaagaccta cctgtactgg      120

ctgttccaga agcccggcaa ggcccccaag cggctgatct acctggtgtc taccctggac      180

tccggcatcc cctcccggtt ctccggctct ggctctggca ccgagttcac cctgaccatc      240

tccagcctgc agcccgagga cttcgccacc tactactgtc tgcaaggcac ccacttcccc      300

cacaccttcg gccagggcac caagctggaa atcaagcgga ccgtggccgc tccctccgtg      360

ttcatcttcc caccctccga cgagcagctg aagtccggca ccgcctccgt cgtgtgcctg      420

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      480

tccggcaact cccaggaatc cgtcaccgag caggactcca aggacagcac ctactccctg      540

tcctccaccc tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccacc agggcctgtc cagccccgtg accaagtcct tcaaccgggg cgagtgc         657



<210>  92
<211>  348
<212>  DNA
<213>  Artificial

<220>
<223>  1519 gH20 V-region (mammalian expression alternative to SEQ ID 
       NO: 31)

<400>  92
gaggtgcccc tggtggaatc tggcggcgga ctggtgcagc ctggcggctc cctgagactg       60

tcttgcgccg tgtccggctt caccttctcc aactacggca tggtctgggt ccgacaggct      120

cctggcaagg gactggaatg ggtggcctac atcgactccg acggcgacaa cacctactac      180

cgggactccg tgaagggccg gttcaccatc tcccgggaca acgccaagtc ctccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgcac caccggcatc      300

gtgcggccct ttctgtactg gggccagggc accctggtca ccgtgtcc                   348



<210>  93
<211>  1332
<212>  DNA
<213>  Artificial

<220>
<223>  1519gH20 IgG4 heavy chain (V + human gamma-4P constant 
       alternative to SEQ ID NO: 44)

<400>  93
gaggtgcccc tggtggaatc tggcggcgga ctggtgcagc ctggcggctc cctgagactg       60

tcttgcgccg tgtccggctt caccttctcc aactacggca tggtctgggt ccgacaggct      120

cctggcaagg gactggaatg ggtggcctac atcgactccg acggcgacaa cacctactac      180

cgggactccg tgaagggccg gttcaccatc tcccgggaca acgccaagtc ctccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgcac caccggcatc      300

gtgcggccct ttctgtactg gggccagggc accctggtca ccgtgtcctc tgcctccacc      360

aagggcccct ccgtgttccc tctggcccct tgctcccggt ccacctccga gtctaccgcc      420

gctctgggct gcctggtcaa ggactacttc cccgagcccg tgacagtgtc ctggaactct      480

ggcgccctga cctccggcgt gcacaccttc cctgccgtgc tgcagtcctc cggcctgtac      540

tccctgtcct ccgtcgtgac cgtgccctcc tccagcctgg gcaccaagac ctacacctgt      600

aacgtggacc acaagccctc caacaccaag gtggacaagc gggtggaatc taagtacggc      660

cctccctgcc ccccctgccc tgcccctgaa tttctgggcg gaccttccgt gttcctgttc      720

cccccaaagc ccaaggacac cctgatgatc tcccggaccc ccgaagtgac ctgcgtggtg      780

gtggacgtgt cccaggaaga tcccgaggtc cagttcaatt ggtacgtgga cggcgtggaa      840

gtgcacaatg ccaagaccaa gcccagagag gaacagttca actccaccta ccgggtggtg      900

tccgtgctga ccgtgctgca ccaggactgg ctgaacggca aagagtacaa gtgcaaggtg      960

tccaacaagg gcctgccctc cagcatcgaa aagaccatct ccaaggccaa gggccagccc     1020

cgcgagcccc aggtgtacac cctgccccct agccaggaag agatgaccaa gaaccaggtg     1080

tccctgacct gtctggtcaa gggcttctac ccctccgaca ttgccgtgga atgggagtcc     1140

aacggccagc ccgagaacaa ctacaagacc accccccctg tgctggacag cgacggctcc     1200

ttcttcctgt actctcggct gaccgtggac aagtcccggt ggcaggaagg caacgtcttc     1260

tcctgctccg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgtccctg     1320

agcctgggca ag                                                         1332


<210>  94
<211>  267
<212>  PRT
<213>  Artificial

<220>
<223>  FcRn alpha chain extracellular sequence

<400>  94

Ala Glu Ser His Leu Ser Leu Leu Tyr His Leu Thr Ala Val Ser Ser 
1               5                   10                  15      


Pro Ala Pro Gly Thr Pro Ala Phe Trp Val Ser Gly Trp Leu Gly Pro 
            20                  25                  30          


Gln Gln Tyr Leu Ser Tyr Asn Ser Leu Arg Gly Glu Ala Glu Pro Cys 
        35                  40                  45              


Gly Ala Trp Val Trp Glu Asn Gln Val Ser Trp Tyr Trp Glu Lys Glu 
    50                  55                  60                  


Thr Thr Asp Leu Arg Ile Lys Glu Lys Leu Phe Leu Glu Ala Phe Lys 
65                  70                  75                  80  


Ala Leu Gly Gly Lys Gly Pro Tyr Thr Leu Gln Gly Leu Leu Gly Cys 
                85                  90                  95      


Glu Leu Gly Pro Asp Asn Thr Ser Val Pro Thr Ala Lys Phe Ala Leu 
            100                 105                 110         


Asn Gly Glu Glu Phe Met Asn Phe Asp Leu Lys Gln Gly Thr Trp Gly 
        115                 120                 125             


Gly Asp Trp Pro Glu Ala Leu Ala Ile Ser Gln Arg Trp Gln Gln Gln 
    130                 135                 140                 


Asp Lys Ala Ala Asn Lys Glu Leu Thr Phe Leu Leu Phe Ser Cys Pro 
145                 150                 155                 160 


His Arg Leu Arg Glu His Leu Glu Arg Gly Arg Gly Asn Leu Glu Trp 
                165                 170                 175     


Lys Glu Pro Pro Ser Met Arg Leu Lys Ala Arg Pro Ser Ser Pro Gly 
            180                 185                 190         


Phe Ser Val Leu Thr Cys Ser Ala Phe Ser Phe Tyr Pro Pro Glu Leu 
        195                 200                 205             


Gln Leu Arg Phe Leu Arg Asn Gly Leu Ala Ala Gly Thr Gly Gln Gly 
    210                 215                 220                 


Asp Phe Gly Pro Asn Ser Asp Gly Ser Phe His Ala Ser Ser Ser Leu 
225                 230                 235                 240 


Thr Val Lys Ser Gly Asp Glu His His Tyr Cys Cys Ile Val Gln His 
                245                 250                 255     


Ala Gly Leu Ala Gln Pro Leu Arg Val Glu Leu Glu Ser Pro Ala Lys 
            260                 265                 270         


Ser Ser 
        


<210>  95
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  95

Ile Gln Lys Thr Pro Gln Ile Gln Val Tyr Ser Arg His Pro Pro Glu 
1               5                   10                  15      


Asn Gly Lys Pro Asn Phe Leu Asn Cys Tyr Val Ser Gln Phe His Pro 
            20                  25                  30          


Pro Gln Ile Glu Ile Glu Leu Leu Lys Asn Gly Lys Lys Ile Pro Asn 
        35                  40                  45              


Ile Glu Met Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Ile 
    50                  55                  60                  


Leu Ala His Thr Glu Phe Thr Pro Thr Glu Thr Asp Val Tyr Ala Cys 
65                  70                  75                  80  


Arg Val Lys His Val Thr Leu Lys Glu Pro Lys Thr Val Thr Trp Asp 
                85                  90                  95      


Arg Asp Met 
            




