               SEQUENCE LISTING

<110> UNIVERSITA' DEGLI STUDI DI PADOVA

<120> MODIFIED HUMAN TYROSINASE AND METHODS FOR ITS PRODUCTION

<130> 11910PTWO

<160> 14

<170> BiSSAP 1.0

<210> 1
<211> 529
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..529
<223> /mol_type="protein"
      /note="human tyrosinase protein sequence (rhTyr)"
      /organism="Homo sapiens"

<400> 1
Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 
1               5                   10                   15    
Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 
            20                   25                  30        
Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 
        35                   40                  45            
Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 
    50                   55                  60                
Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 
65                   70                  75                  80
Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 
                85                   90                  95    
Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 
            100                  105                110        
Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 
        115                  120                125            
Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 
    130                  135                140                
Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 
145                  150                155                  160
Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 
                165                  170                175    
Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser 
            180                  185                190        
Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 
        195                  200                205            
Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 
    210                  215                220                
Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 
225                  230                235                  240
Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His 
                245                  250                255    
Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 
            260                  265                270        
Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 
        275                  280                285            
Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 
    290                  295                300                
Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
305                  310                315                  320
Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 
                325                  330                335    
Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 
            340                  345                350        
Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 
        355                  360                365            
Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 
    370                  375                380                
Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp 
385                  390                395                  400
Leu Arg Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 
                405                  410                415    
Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 
            420                  425                430        
Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 
        435                  440                445            
Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 
    450                  455                460                
Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 
465                  470                475                  480
Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 
                485                  490                495    
Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 
            500                  505                510        
Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 
        515                  520                525            
Leu 
    

<210> 2
<211> 1912
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1912
<223> /mol_type="DNA"
      /note="human tyrosinase nucleotide sequence (rhTyr)"
      /organism="Homo sapiens"

<400> 2
gaattcgagg aagaatgctc ctggctgttt tgtactgcct gctgtggagt ttccagacct      60

ccgctggcca tttccctaga gcctgtgtct cctctaagaa cctgatggag aaggaatgct     120

gtccaccgtg gagcggggac aggagtccct gtggccagct ttcaggcaga ggttcctgtc     180

agaatatcct tctgtccaat gcaccacttg ggcctcaatt tcccttcaca ggggtggatg     240

accgggagtc gtggccttcc gtcttttata ataggacctg ccagtgctct ggcaacttca     300

tgggattcaa ctgtggaaac tgcaagtttg gcttttgggg accaaactgc acagagagac     360

gactcttggt gagaagaaac atcttcgatt tgagtgcccc agagaaggac aaattttttg     420

cctacctcac tttagcaaag cataccatca gctcagacta tgtcatcccc atagggacct     480

atggccaaat gaaaaatgga tcaacaccca tgtttaacga catcaatatt tatgacctct     540

ttgtctggat gcattattat gtgtcaatgg atgcactgct tgggggatct gaaatctgga     600

gagacattga ttttgcccat gaagcaccag cttttctgcc ttggcataga ctcttcttgt     660

tgcggtggga acaagaaatc cagaagctga caggagatga aaacttcact attccatatt     720

gggactggcg ggatgcagaa aagtgtgaca tttgcacaga tgagtacatg ggaggtcagc     780

accccacaaa tcctaactta ctcagcccag catcattctt ctcctcttgg cagattgtct     840

gtagccgatt ggaggagtac aacagccatc agtctttatg caatggaacg cccgagggac     900

ctttacggcg taatcctgga aaccatgaca aatccagaac cccaaggctc ccctcttcag     960

ctgatgtaga attttgcctg agtttgaccc aatatgaatc tggttccatg gataaagctg    1020

ccaatttcag ctttagaaat acactggaag gatttgctag tccacttact gggatagcgg    1080

atgcctctca aagcagcatg cacaatgcct tgcacatcta tatgaatgga acaatgtccc    1140

aggtacaggg atctgccaac gatcctatct tccttcttca ccatgcattt gttgacagta    1200

tttttgagca gtggctccga aggcaccgtc ctcttcaaga agtttatcca gaagccaatg    1260

cacccattgg acataaccgg gaatcctaca tggttccttt tataccactg tacagaaatg    1320

gtgatttctt tatttcatcc aaagatctgg gctatgacta tagctatcta caagattcag    1380

acccagactc ttttcaagac tacattaagt cctatttgga acaagcgagt cggatctggt    1440

catggctcct tggggcggcg atggtagggg ccgtcctcac tgccctgctg gcagggcttg    1500

tgagcttgct gtgtcgtcac aagagaaagc agcttcctga agaaaagcag ccactcctca    1560

tggagaaaga ggattaccac agcttgtatc agagccattt ataaaaggct taggcaatag    1620

agtagggcca aaaagcctga cctcactcta actcaaagta atgtccaggt tcccagagaa    1680

tatctgctgg tatttttctg taaagaccat ttgcaaaatt gtaacctaat acaaagtgta    1740

gccttcttcc aactcaggta gaacacacct gtctttgtct tgctgttttc actcagccct    1800

tttaacattt tcccctaagc ccatatgtct aaggaaagga tgctatttgg taatgaggaa    1860

ctgttatttg tatgtgaatt aaagtgctct tatttttaaa aaaccggaat tc            1912


<210> 3
<211> 535
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..535
<223> /mol_type="protein"
      /note="modified human tyrosinase protein sequence (Tyr_HT)"
      /organism="Homo sapiens"

<400> 3
Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 
1               5                   10                   15    
Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 
            20                   25                  30        
Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 
        35                   40                  45            
Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 
    50                   55                  60                
Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 
65                   70                  75                  80
Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 
                85                   90                  95    
Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 
            100                  105                110        
Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 
        115                  120                125            
Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 
    130                  135                140                
Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 
145                  150                155                  160
Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 
                165                  170                175    
Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser 
            180                  185                190        
Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 
        195                  200                205            
Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 
    210                  215                220                
Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 
225                  230                235                  240
Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His 
                245                  250                255    
Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 
            260                  265                270        
Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 
        275                  280                285            
Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 
    290                  295                300                
Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
305                  310                315                  320
Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 
                325                  330                335    
Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 
            340                  345                350        
Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 
        355                  360                365            
Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 
    370                  375                380                
Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp 
385                  390                395                  400
Leu Arg Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 
                405                  410                415    
Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 
            420                  425                430        
Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 
        435                  440                445            
Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 
    450                  455                460                
Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 
465                  470                475                  480
Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 
                485                  490                495    
Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 
            500                  505                510        
Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 
        515                  520                525            
Leu His His His His His His 
    530                  535

<210> 4
<211> 1630
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1630
<223> /mol_type="DNA"
      /note="modified human tyrosinase nucleotide sequence (Tyr_HT)"
      /organism="Homo sapiens"

<400> 4
gaattccggg aagaatgctc ctggctgttt tgtactgcct gctgtggagt ttccagacct      60

ccgctggcca tttccctaga gcctgtgtct cctctaagaa cctgatggag aaggaatgct     120

gtccaccgtg gagcggggac aggagtccct gtggccagct ttcaggcaga ggttcctgtc     180

agaatatcct tctgtccaat gcaccacttg ggcctcaatt tcccttcaca ggggtggatg     240

accgggagtc gtggccttcc gtcttttata ataggacctg ccagtgctct ggcaacttca     300

tgggattcaa ctgtggaaac tgcaagtttg gcttttgggg accaaactgc acagagagac     360

gactcttggt gagaagaaac atcttcgatt tgagtgcccc agagaaggac aaattttttg     420

cctacctcac tttagcaaag cataccatca gctcagacta tgtcatcccc atagggacct     480

atggccaaat gaaaaatgga tcaacaccca tgtttaacga catcaatatt tatgacctct     540

ttgtctggat gcattattat gtgtcaatgg atgcactgct tgggggatat gaaatctgga     600

gagacattga ttttgcccat gaagcaccag cttttctgcc ttggcataga ctcttcttgt     660

tgcggtggga acaagaaatc cagaagctga caggagatga aaacttcact attccatatt     720

gggactggcg ggatgcagaa aagtgtgaca tttgcacaga tgagtacatg ggaggtcagc     780

accccacaaa tcctaactta ctcagcccag catcattctt ctcctcttgg cagattgtct     840

gtagccgatt ggaggagtac aacagccatc agtctttatg caatggaacg cccgagggac     900

ctttacggcg taatcctgga aaccatgaca aatccagaac cccaaggctc ccctcttcag     960

ctgatgtaga attttgcctg agtttgaccc aatatgaatc tggttccatg gataaagctg    1020

ccaatttcag ctttagaaat acactggaag gatttgctag tccacttact gggatagcgg    1080

atgcctctca aagcagcatg cacaatgcct tgcacatcta tatgaatgga acaatgtccc    1140

aggtacaggg atctgccaac gatcctatct tccttcttca ccatgcattt gttgacagta    1200

tttttgagca gtggctccga aggcaccgtc ctcttcaaga agtttatcca gaagccaatg    1260

cacccattgg acataaccgg gaatcctaca tggttccttt tataccactg tacagaaatg    1320

gtgatttctt tatttcatcc aaagatctgg gctatgacta tagctatcta caagattcag    1380

acccagactc ttttcaagac tacattaagt cctatttgga acaagcgagt cggatctggt    1440

catggctcct tggggcggcg atggtagggg ccgtcctcac tgccctgctg gcagggcttg    1500

tgagcttgct gtgtcgtcac aagagaaagc agcttcctga agaaaagcag ccactcctca    1560

tggagaaaga ggattaccac agcttgtatc agagccattt acaccaccac caccaccact    1620

aagcggccgc                                                           1630


<210> 5
<211> 524
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..524
<223> /mol_type="protein"
      /note="modified human tyrosinase protein sequence (Tyr_ENT)"
      /organism="Homo sapiens"

<400> 5
Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 
1               5                   10                   15    
Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 
            20                   25                  30        
Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 
        35                   40                  45            
Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 
    50                   55                  60                
Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 
65                   70                  75                  80
Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 
                85                   90                  95    
Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 
            100                  105                110        
Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 
        115                  120                125            
Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 
    130                  135                140                
Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 
145                  150                155                  160
Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 
                165                  170                175    
Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser 
            180                  185                190        
Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 
        195                  200                205            
Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 
    210                  215                220                
Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 
225                  230                235                  240
Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His 
                245                  250                255    
Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 
            260                  265                270        
Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 
        275                  280                285            
Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 
    290                  295                300                
Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
305                  310                315                  320
Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 
                325                  330                335    
Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 
            340                  345                350        
Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 
        355                  360                365            
Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 
    370                  375                380                
Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp 
385                  390                395                  400
Leu Arg Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 
                405                  410                415    
Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 
            420                  425                430        
Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 
        435                  440                445            
Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 
    450                  455                460                
Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 
465                  470                475                  480
Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 
                485                  490                495    
Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 
            500                  505                510        
Pro Asp Asp Asp Asp Lys His His His His His His 
        515                  520                

<210> 6
<211> 1597
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1597
<223> /mol_type="DNA"
      /note="modified human tyrosinase nucleotide sequence (Tyr_ENT)"
      /organism="Homo sapiens"

<400> 6
gaattccggg aagaatgctc ctggctgttt tgtactgcct gctgtggagt ttccagacct      60

ccgctggcca tttccctaga gcctgtgtct cctctaagaa cctgatggag aaggaatgct     120

gtccaccgtg gagcggggac aggagtccct gtggccagct ttcaggcaga ggttcctgtc     180

agaatatcct tctgtccaat gcaccacttg ggcctcaatt tcccttcaca ggggtggatg     240

accgggagtc gtggccttcc gtcttttata ataggacctg ccagtgctct ggcaacttca     300

tgggattcaa ctgtggaaac tgcaagtttg gcttttgggg accaaactgc acagagagac     360

gactcttggt gagaagaaac atcttcgatt tgagtgcccc agagaaggac aaattttttg     420

cctacctcac tttagcaaag cataccatca gctcagacta tgtcatcccc atagggacct     480

atggccaaat gaaaaatgga tcaacaccca tgtttaacga catcaatatt tatgacctct     540

ttgtctggat gcattattat gtgtcaatgg atgcactgct tgggggatat gaaatctgga     600

gagacattga ttttgcccat gaagcaccag cttttctgcc ttggcataga ctcttcttgt     660

tgcggtggga acaagaaatc cagaagctga caggagatga aaacttcact attccatatt     720

gggactggcg ggatgcagaa aagtgtgaca tttgcacaga tgagtacatg ggaggtcagc     780

accccacaaa tcctaactta ctcagcccag catcattctt ctcctcttgg cagattgtct     840

gtagccgatt ggaggagtac aacagccatc agtctttatg caatggaacg cccgagggac     900

ctttacggcg taatcctgga aaccatgaca aatccagaac cccaaggctc ccctcttcag     960

ctgatgtaga attttgcctg agtttgaccc aatatgaatc tggttccatg gataaagctg    1020

ccaatttcag ctttagaaat acactggaag gatttgctag tccacttact gggatagcgg    1080

atgcctctca aagcagcatg cacaatgcct tgcacatcta tatgaatgga acaatgtccc    1140

aggtacaggg atctgccaac gatcctatct tccttcttca ccatgcattt gttgacagta    1200

tttttgagca gtggctccga aggcaccgtc ctcttcaaga agtttatcca gaagccaatg    1260

cacccattgg acataaccgg gaatcctaca tggttccttt tataccactg tacagaaatg    1320

gtgatttctt tatttcatcc aaagatctgg gctatgacta tagctatcta caagattcag    1380

acccagactc ttttcaagac tacattaagt cctatttgga acaagcgagt cggatctggt    1440

catggctcct tggggcggcg atggtagggg ccgtcctcac tgccctgctg gcagggcttg    1500

tgagcttgct gtgtcgtcac aagagaaagc agcttcctga agaaaagcag ccagacgacg    1560

acgacaaaca ccaccaccac caccactaag cggccgc                             1597


<210> 7
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..20
<223> /mol_type="DNA"
      /note="Tyr1Rev"
      /organism="Homo sapiens"

<400> 7
tcctccaatc ggctacagac                                                20


<210> 8
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..20
<223> /mol_type="DNA"
      /note="Tyr2Fow"
      /organism="Homo sapiens"

<400> 8
attgattttg cccatgaagc                                                20


<210> 9
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..20
<223> /mol_type="DNA"
      /note="Tyr3Fow"
      /organism="Homo sapiens"

<400> 9
tccacttact gggatagcgg                                                20


<210> 10
<211> 26
<212> DNA
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..26
<223> /mol_type="DNA"
      /note="tyrfor"
      /organism="Homo sapiens"

<400> 10
tgtagaattt tgcctgagtt tgaccc                                         26


<210> 11
<211> 56
<212> DNA
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..56
<223> /mol_type="DNA"
      /note="tyrHTrev"
      /organism="Homo sapiens"

<400> 11
tggccctact ctattgcggc cgcttagtgg tggtggtggt ggtgtaaatg gctctg         56


<210> 12
<211> 68
<212> DNA
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..68
<223> /mol_type="DNA"
      /note="tyrHTEntrev"
      /organism="Homo sapiens"

<400> 12
tttctccatg aggcggccgc ttagtggtgg tggtggtggt gtttgtcgtc gtcgtctggc     60

tgcttttc                                                              68


<210> 13
<211> 15
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..15
<223> /mol_type="protein"
      /note="amino acid sequence recognized by T311"
      /organism="Homo sapiens"

<400> 13
Ile Pro Tyr Trp Asp Trp Arg Asp Ala Glu Lys Cys Asp Ile Cys 
1               5                   10                   15

<210> 14
<211> 16
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..16
<223> /mol_type="protein"
      /note="amino acid sequence recognized by PEP7h"
      /organism="Homo sapiens"

<400> 14
Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 
1               5                   10                   15    

