                         SEQUENCE LISTING

<110>  Aragon Pharmaceuticals, Inc.
       Joseph, James David
       Hager, Jeffrey H.
       Sensintaffar, John Lee
       Lu, Nhin
       Qian, Jing
       Smith, Nicholas D.
 
<120>  METHODS AND COMPOSITIONS FOR DETERMINING RESISTANCE TO ANDROGEN 
       RECEPTOR THERAPY

<130>  38937-725.601

<150>  61/676,842
<151>  2012-07-27

<150>  61/783,763
<151>  2013-03-14

<150>  61/829,123
<151>  2013-05-30

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  919
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu Thr 
65                  70                  75                  80  


Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser Pro Gln 
                85                  90                  95      


Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu Glu Gln 
            100                 105                 110         


Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu Arg Gly 
        115                 120                 125             


Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly Leu Pro 
    130                 135                 140                 


Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala Pro Ser 
145                 150                 155                 160 


Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser Cys Ser 
                165                 170                 175     


Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln Leu Leu 
            180                 185                 190         


Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser Gly Arg 
        195                 200                 205             


Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn Tyr Leu 
    210                 215                 220                 


Gly Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys Lys Ala 
225                 230                 235                 240 


Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His Leu Ser 
                245                 250                 255     


Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu Leu Gly 
            260                 265                 270         


Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala Glu Cys 
        275                 280                 285             


Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu Asp Thr 
    290                 295                 300                 


Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu Glu Gly 
305                 310                 315                 320 


Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser Gly Thr 
                325                 330                 335     


Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala Leu Asp 
            340                 345                 350         


Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro Leu Ala 
        355                 360                 365             


Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His Ala Arg 
    370                 375                 380                 


Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala Ala Ala 
385                 390                 395                 400 


Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly Ala Gly 
                405                 410                 415     


Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser Ser Ser 
            420                 425                 430         


Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly Pro Cys 
        435                 440                 445             


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro Tyr 
465                 470                 475                 480 


Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp Phe 
                485                 490                 495     


Thr Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val Pro 
            500                 505                 510         


Tyr Pro Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met Asp 
        515                 520                 525             


Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala Arg Asp 
    530                 535                 540                 


His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys Leu 
545                 550                 555                 560 


Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr Cys 
                565                 570                 575     


Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln Lys 
            580                 585                 590         


Tyr Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg Arg 
        595                 600                 605             


Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly Met 
    610                 615                 620                 


Thr Leu Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu Gln 
625                 630                 635                 640 


Glu Glu Gly Glu Ala Ser Ser Thr Thr Ser Pro Thr Glu Glu Thr Thr 
                645                 650                 655     


Gln Lys Leu Thr Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro Ile 
            660                 665                 670         


Phe Leu Asn Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala Gly 
        675                 680                 685             


His Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser Leu 
    690                 695                 700                 


Asn Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala Lys 
705                 710                 715                 720 


Ala Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala Val 
                725                 730                 735     


Ile Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp Arg 
            740                 745                 750         


Ser Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp Leu 
        755                 760                 765             


Val Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln Cys 
    770                 775                 780                 


Val Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile Thr 
785                 790                 795                 800 


Pro Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile Ile 
                805                 810                 815     


Pro Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg Met 
            820                 825                 830         


Asn Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys Asn 
        835                 840                 845             


Pro Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp 
    850                 855                 860                 


Ser Val Gln Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp Leu 
865                 870                 875                 880 


Leu Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met Ala 
                885                 890                 895     


Glu Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val Lys 
            900                 905                 910         


Pro Ile Tyr Phe His Thr Gln 
        915                 


<210>  2
<211>  920
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Glu Thr Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser 
                85                  90                  95      


Pro Gln Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu 
            100                 105                 110         


Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu 
        115                 120                 125             


Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly 
    130                 135                 140                 


Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala 
145                 150                 155                 160 


Pro Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser 
                165                 170                 175     


Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln 
            180                 185                 190         


Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser 
        195                 200                 205             


Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn 
    210                 215                 220                 


Tyr Leu Gly Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys 
225                 230                 235                 240 


Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His 
                245                 250                 255     


Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu 
            260                 265                 270         


Leu Gly Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala 
        275                 280                 285             


Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu 
    290                 295                 300                 


Asp Thr Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser 
                325                 330                 335     


Gly Thr Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala 
            340                 345                 350         


Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro 
        355                 360                 365             


Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His 
    370                 375                 380                 


Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly 
                405                 410                 415     


Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser 
            420                 425                 430         


Ser Ser Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly 
        435                 440                 445             


Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro 
465                 470                 475                 480 


Tyr Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp 
                485                 490                 495     


Phe Thr Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val 
            500                 505                 510         


Pro Tyr Pro Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met 
        515                 520                 525             


Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala Arg 
    530                 535                 540                 


Asp His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys 
545                 550                 555                 560 


Leu Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr 
                565                 570                 575     


Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln 
            580                 585                 590         


Lys Tyr Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg 
        595                 600                 605             


Arg Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly 
    610                 615                 620                 


Met Thr Leu Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu 
625                 630                 635                 640 


Gln Glu Glu Gly Glu Ala Ser Ser Thr Thr Ser Pro Thr Glu Glu Thr 
                645                 650                 655     


Thr Gln Lys Leu Thr Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro 
            660                 665                 670         


Ile Phe Leu Asn Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala 
        675                 680                 685             


Gly His Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser 
    690                 695                 700                 


Leu Asn Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala 
705                 710                 715                 720 


Lys Ala Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala 
                725                 730                 735     


Val Ile Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp 
            740                 745                 750         


Arg Ser Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp 
        755                 760                 765             


Leu Val Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln 
    770                 775                 780                 


Cys Val Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile 
785                 790                 795                 800 


Thr Pro Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile 
                805                 810                 815     


Ile Pro Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg 
            820                 825                 830         


Met Asn Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys 
        835                 840                 845             


Asn Pro Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
    850                 855                 860                 


Asp Ser Val Gln Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp 
865                 870                 875                 880 


Leu Leu Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met 
                885                 890                 895     


Ala Glu Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val 
            900                 905                 910         


Lys Pro Ile Tyr Phe His Thr Gln 
        915                 920 


<210>  3
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  3

Tyr Tyr Phe Pro Pro Gln Lys Thr Cys Leu Ile Cys Gly Asp Glu Ala 
1               5                   10                  15      


Ser Gly Cys His Tyr Gly Ala Leu Thr Cys Gly Ser Cys Lys Val Phe 
            20                  25                  30          


Phe Lys Arg Ala Ala Glu Gly Lys Gln Lys Tyr Leu Cys Ala Ser Arg 
        35                  40                  45              


Asn Asp Cys Thr Ile Asp Lys Phe Arg Arg Lys Asn Cys Pro Ser Cys 
    50                  55                  60                  


Arg Leu Arg Lys Cys Tyr Glu Ala Gly Met Thr Leu Gly Ala Arg Lys 
65                  70                  75                  80  


Leu Lys Lys Leu Gly Asn Leu Lys Leu Gln Glu Glu Gly Glu Ala Ser 
                85                  90                  95      


Ser Thr Thr Ser Pro Thr Glu Glu Thr Thr Gln Lys Leu Thr Val Ser 
            100                 105                 110         


His Ile Glu Gly Tyr Glu Cys Gln Pro Ile Phe Leu Asn Val Leu Glu 
        115                 120                 125             


Ala Ile Glu Pro Gly Val Val Cys Ala Gly His Asp Asn Asn Gln Pro 
    130                 135                 140                 


Asp Ser Phe Ala Ala Leu Leu Ser Ser Leu Asn Glu Leu Gly Glu Arg 
145                 150                 155                 160 


Gln Leu Val His Val Val Lys Trp Ala Lys Ala Leu Pro Gly Phe Arg 
                165                 170                 175     


Asn Leu His Val Asp Asp Gln Met Ala Val Ile Gln Tyr Ser Trp Met 
            180                 185                 190         


Gly Leu Met Val Phe Ala Met Gly Trp Arg Ser Phe Thr Asn Val Asn 
        195                 200                 205             


Ser Arg Met Leu Tyr Phe Ala Pro Asp Leu Val Phe Asn Glu Tyr Arg 
    210                 215                 220                 


Met His Lys Ser Arg Met Tyr Ser Gln Cys Val Arg Met Arg His Leu 
225                 230                 235                 240 


Ser Gln Glu Phe Gly Trp Leu Gln Ile Thr Pro Gln Glu Phe Leu Cys 
                245                 250                 255     


Met Lys Ala Leu Leu Leu Phe Ser Ile Ile Pro Val Asp Gly Leu Lys 
            260                 265                 270         


Asn Gln Lys Phe Phe Asp Glu Leu Arg Met Asn Tyr Ile Lys Glu Leu 
        275                 280                 285             


Asp Arg Ile Ile Ala Cys Lys Arg Lys Asn Pro Thr Ser Cys Ser Arg 
    290                 295                 300                 


Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser Val Gln Pro Ile Ala 
305                 310                 315                 320 


Arg Glu Leu His Gln Phe Thr Phe Asp Leu Leu Ile Lys Ser His Met 
                325                 330                 335     


Val Ser Val Asp Phe Pro Glu Met Met Ala Glu Ile Ile Ser Val Gln 
            340                 345                 350         


Val Pro Lys Ile Leu Ser Gly Lys Val Lys Pro Ile Tyr Phe His Thr 
        355                 360                 365             


Gln 
    


<210>  4
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser Leu Asn 
1               5                   10                  15      


Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala Lys Ala 
            20                  25                  30          


Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala Val Ile 
        35                  40                  45              


Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp Arg Ser 
    50                  55                  60                  


Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp Leu Val 
65                  70                  75                  80  


Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln Cys Val 
                85                  90                  95      


Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile Thr Pro 
            100                 105                 110         


Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile Ile Pro 
        115                 120                 125             


Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg Met Asn 
    130                 135                 140                 


Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys Asn Pro 
145                 150                 155                 160 


Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser 
                165                 170                 175     


Val Gln Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp Leu Leu 
            180                 185                 190         


Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met Ala Glu 
        195                 200                 205             


Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val Lys Pro 
    210                 215                 220                 


Ile Tyr Phe His Thr Gln 
225                 230 


<210>  5
<211>  919
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu Thr 
65                  70                  75                  80  


Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser Pro Gln 
                85                  90                  95      


Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu Glu Gln 
            100                 105                 110         


Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu Arg Gly 
        115                 120                 125             


Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly Leu Pro 
    130                 135                 140                 


Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala Pro Ser 
145                 150                 155                 160 


Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser Cys Ser 
                165                 170                 175     


Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln Leu Leu 
            180                 185                 190         


Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser Gly Arg 
        195                 200                 205             


Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn Tyr Leu 
    210                 215                 220                 


Gly Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys Lys Ala 
225                 230                 235                 240 


Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His Leu Ser 
                245                 250                 255     


Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu Leu Gly 
            260                 265                 270         


Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala Glu Cys 
        275                 280                 285             


Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu Asp Thr 
    290                 295                 300                 


Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu Glu Gly 
305                 310                 315                 320 


Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser Gly Thr 
                325                 330                 335     


Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala Leu Asp 
            340                 345                 350         


Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro Leu Ala 
        355                 360                 365             


Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His Ala Arg 
    370                 375                 380                 


Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala Ala Ala 
385                 390                 395                 400 


Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly Ala Gly 
                405                 410                 415     


Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser Ser Ser 
            420                 425                 430         


Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly Pro Cys 
        435                 440                 445             


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro Tyr 
465                 470                 475                 480 


Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp Phe 
                485                 490                 495     


Thr Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val Pro 
            500                 505                 510         


Tyr Pro Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met Asp 
        515                 520                 525             


Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala Arg Asp 
    530                 535                 540                 


His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys Leu 
545                 550                 555                 560 


Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr Cys 
                565                 570                 575     


Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln Lys 
            580                 585                 590         


Tyr Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg Arg 
        595                 600                 605             


Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly Met 
    610                 615                 620                 


Thr Leu Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu Gln 
625                 630                 635                 640 


Glu Glu Gly Glu Ala Ser Ser Thr Thr Ser Pro Thr Glu Glu Thr Thr 
                645                 650                 655     


Gln Lys Leu Thr Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro Ile 
            660                 665                 670         


Phe Leu Asn Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala Gly 
        675                 680                 685             


His Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser Leu 
    690                 695                 700                 


Asn Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala Lys 
705                 710                 715                 720 


Ala Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala Val 
                725                 730                 735     


Ile Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp Arg 
            740                 745                 750         


Ser Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp Leu 
        755                 760                 765             


Val Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln Cys 
    770                 775                 780                 


Val Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile Thr 
785                 790                 795                 800 


Pro Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile Ile 
                805                 810                 815     


Pro Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg Met 
            820                 825                 830         


Asn Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys Asn 
        835                 840                 845             


Pro Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp 
    850                 855                 860                 


Ser Val Gln Pro Ile Ala Arg Glu Leu His Gln Leu Thr Phe Asp Leu 
865                 870                 875                 880 


Leu Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met Ala 
                885                 890                 895     


Glu Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val Lys 
            900                 905                 910         


Pro Ile Tyr Phe His Thr Gln 
        915                 


<210>  6
<211>  902
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Ala Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ile Ala 
        35                  40                  45              


Pro Pro Gly Ala Cys Leu Gln Gln Arg Gln Glu Thr Ser Pro Arg Arg 
    50                  55                  60                  


Arg Arg Arg Gln Gln His Pro Glu Asp Gly Ser Pro Gln Ala His Ile 
65                  70                  75                  80  


Arg Gly Thr Thr Gly Tyr Leu Ala Leu Glu Glu Glu Gln Gln Pro Ser 
                85                  90                  95      


Gln Gln Gln Ser Ala Ser Glu Gly His Pro Glu Ser Gly Cys Leu Pro 
            100                 105                 110         


Glu Pro Gly Ala Ala Thr Ala Pro Gly Lys Gly Leu Pro Gln Gln Pro 
        115                 120                 125             


Pro Ala Pro Pro Asp Gln Asp Asp Ser Ala Ala Pro Ser Thr Leu Ser 
    130                 135                 140                 


Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser Cys Ser Ala Asp Ile 
145                 150                 155                 160 


Lys Asp Ile Leu Ser Glu Ala Gly Thr Met Gln Leu Leu Gln Gln Gln 
                165                 170                 175     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            180                 185                 190         


Gln Gln Gln Glu Val Ile Ser Glu Gly Ser Ser Ser Val Arg Ala Arg 
        195                 200                 205             


Glu Ala Thr Gly Ala Pro Ser Ser Ser Lys Asp Ser Tyr Leu Gly Gly 
    210                 215                 220                 


Asn Ser Thr Ile Ser Asp Ser Ala Lys Glu Leu Cys Lys Ala Val Ser 
225                 230                 235                 240 


Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His Leu Ser Pro Gly 
                245                 250                 255     


Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Ser Leu Leu Gly Gly Pro 
            260                 265                 270         


Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala Glu Cys Lys Gly 
        275                 280                 285             


Leu Ser Leu Asp Glu Gly Pro Gly Lys Gly Thr Glu Glu Thr Ala Glu 
    290                 295                 300                 


Tyr Ser Ser Phe Lys Gly Gly Tyr Ala Lys Gly Leu Glu Gly Glu Ser 
305                 310                 315                 320 


Leu Gly Cys Ser Gly Ser Ser Glu Ala Gly Ser Ser Gly Thr Leu Glu 
                325                 330                 335     


Ile Pro Ser Ser Leu Ser Leu Tyr Lys Ser Gly Ala Val Asp Glu Ala 
            340                 345                 350         


Ala Ala Tyr Gln Asn Arg Asp Tyr Tyr Asn Phe Pro Leu Ala Leu Ser 
        355                 360                 365             


Gly Pro Pro His Pro Pro Pro Pro Thr His Pro His Ala Arg Ile Lys 
    370                 375                 380                 


Leu Glu Asn Pro Ser Asp Tyr Gly Ser Ala Trp Ala Ala Ala Ala Ala 
385                 390                 395                 400 


Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly Gly Ser Val Ala 
                405                 410                 415     


Gly Pro Ser Thr Gly Ser Pro Pro Ala Thr Ala Ser Ser Ser Trp His 
            420                 425                 430         


Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly Pro Gly Gly Gly 
        435                 440                 445             


Gly Gly Ser Ser Ser Pro Ser Asp Ala Gly Pro Val Ala Pro Tyr Gly 
    450                 455                 460                 


Tyr Thr Arg Pro Pro Gln Gly Leu Ala Ser Gln Glu Gly Asp Phe Ser 
465                 470                 475                 480 


Ala Ser Glu Val Trp Tyr Pro Gly Gly Val Val Asn Arg Val Pro Tyr 
                485                 490                 495     


Pro Ser Pro Ser Cys Val Lys Ser Glu Met Gly Pro Trp Met Glu Asn 
            500                 505                 510         


Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Asp Ser Thr Arg Asp His 
        515                 520                 525             


Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys Leu Ile 
    530                 535                 540                 


Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr Cys Gly 
545                 550                 555                 560 


Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln Lys Tyr 
                565                 570                 575     


Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg Arg Lys 
            580                 585                 590         


Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly Met Thr 
        595                 600                 605             


Leu Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu Gln Glu 
    610                 615                 620                 


Glu Gly Glu Asn Ser Ser Ala Gly Ser Pro Thr Glu Asp Pro Ser Gln 
625                 630                 635                 640 


Lys Met Thr Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro Ile Phe 
                645                 650                 655     


Leu Asn Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala Gly His 
            660                 665                 670         


Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser Leu Asn 
        675                 680                 685             


Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala Lys Ala 
    690                 695                 700                 


Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala Val Ile 
705                 710                 715                 720 


Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp Arg Ser 
                725                 730                 735     


Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp Leu Val 
            740                 745                 750         


Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln Cys Val 
        755                 760                 765             


Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile Thr Pro 
    770                 775                 780                 


Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile Ile Pro 
785                 790                 795                 800 


Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg Met Asn 
                805                 810                 815     


Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys Asn Pro 
            820                 825                 830         


Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser 
        835                 840                 845             


Val Gln Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp Leu Leu 
    850                 855                 860                 


Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met Ala Glu 
865                 870                 875                 880 


Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val Lys Pro 
                885                 890                 895     


Ile Tyr Phe His Thr Gln 
            900         


<210>  7
<211>  899
<212>  PRT
<213>  Mus musculus

<400>  7

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Ala Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Asn Ile Ala 
        35                  40                  45              


Pro Pro Gly Ala Cys Leu Gln Gln Arg Gln Glu Thr Ser Pro Arg Arg 
    50                  55                  60                  


Arg Arg Arg Gln Gln His Thr Glu Asp Gly Ser Pro Gln Ala His Ile 
65                  70                  75                  80  


Arg Gly Pro Thr Gly Tyr Leu Ala Leu Glu Glu Glu Gln Gln Pro Ser 
                85                  90                  95      


Gln Gln Gln Ala Ala Ser Glu Gly His Pro Glu Ser Ser Cys Leu Pro 
            100                 105                 110         


Glu Pro Gly Ala Ala Thr Ala Pro Gly Lys Gly Leu Pro Gln Gln Pro 
        115                 120                 125             


Pro Ala Pro Pro Asp Gln Asp Asp Ser Ala Ala Pro Ser Thr Leu Ser 
    130                 135                 140                 


Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser Cys Ser Ala Asp Ile 
145                 150                 155                 160 


Lys Asp Ile Leu Asn Glu Ala Gly Thr Met Gln Leu Leu Gln Gln Gln 
                165                 170                 175     


Gln Gln Gln Gln Gln His Gln Gln Gln His Gln Gln His Gln Gln Gln 
            180                 185                 190         


Gln Glu Val Ile Ser Glu Gly Ser Ser Ala Arg Ala Arg Glu Ala Thr 
        195                 200                 205             


Gly Ala Pro Ser Ser Ser Lys Asp Ser Tyr Leu Gly Gly Asn Ser Thr 
    210                 215                 220                 


Ile Ser Asp Ser Ala Lys Glu Leu Cys Lys Ala Val Ser Val Ser Met 
225                 230                 235                 240 


Gly Leu Gly Val Glu Ala Leu Glu His Leu Ser Pro Gly Glu Gln Leu 
                245                 250                 255     


Arg Gly Asp Cys Met Tyr Ala Ser Leu Leu Gly Gly Pro Pro Ala Val 
            260                 265                 270         


Arg Pro Thr Pro Cys Ala Pro Leu Pro Glu Cys Lys Gly Leu Pro Leu 
        275                 280                 285             


Asp Glu Gly Pro Gly Lys Ser Thr Glu Glu Thr Ala Glu Tyr Ser Ser 
    290                 295                 300                 


Phe Lys Gly Gly Tyr Ala Lys Gly Leu Glu Gly Glu Ser Leu Gly Cys 
305                 310                 315                 320 


Ser Gly Ser Ser Glu Ala Gly Ser Ser Gly Thr Leu Glu Ile Pro Ser 
                325                 330                 335     


Ser Leu Ser Leu Tyr Lys Ser Gly Ala Leu Asp Glu Ala Ala Ala Tyr 
            340                 345                 350         


Gln Asn Arg Asp Tyr Tyr Asn Phe Pro Leu Ala Leu Ser Gly Pro Pro 
        355                 360                 365             


His Pro Pro Pro Pro Thr His Pro His Ala Arg Ile Lys Leu Glu Asn 
    370                 375                 380                 


Pro Leu Asp Tyr Gly Ser Ala Trp Ala Ala Ala Ala Ala Gln Cys Arg 
385                 390                 395                 400 


Tyr Gly Asp Leu Gly Ser Leu His Gly Gly Ser Val Ala Gly Pro Ser 
                405                 410                 415     


Thr Gly Ser Pro Pro Ala Thr Thr Ser Ser Ser Trp His Thr Leu Phe 
            420                 425                 430         


Thr Ala Glu Glu Gly Gln Leu Tyr Gly Pro Gly Gly Gly Gly Gly Ser 
        435                 440                 445             


Ser Ser Pro Ser Asp Ala Gly Pro Val Ala Pro Tyr Gly Tyr Thr Arg 
    450                 455                 460                 


Pro Pro Gln Gly Leu Thr Ser Gln Glu Ser Asp Tyr Ser Ala Ser Glu 
465                 470                 475                 480 


Val Trp Tyr Pro Gly Gly Val Val Asn Arg Val Pro Tyr Pro Ser Pro 
                485                 490                 495     


Asn Cys Val Lys Ser Glu Met Gly Pro Trp Met Glu Asn Tyr Ser Gly 
            500                 505                 510         


Pro Tyr Gly Asp Met Arg Leu Asp Ser Thr Arg Asp His Val Leu Pro 
        515                 520                 525             


Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys Leu Ile Cys Gly Asp 
    530                 535                 540                 


Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr Cys Gly Ser Cys Lys 
545                 550                 555                 560 


Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln Lys Tyr Leu Cys Ala 
                565                 570                 575     


Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg Arg Lys Asn Cys Pro 
            580                 585                 590         


Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly Met Thr Leu Gly Ala 
        595                 600                 605             


Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu Gln Glu Glu Gly Glu 
    610                 615                 620                 


Asn Ser Asn Ala Gly Ser Pro Thr Glu Asp Pro Ser Gln Lys Met Thr 
625                 630                 635                 640 


Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro Ile Phe Leu Asn Val 
                645                 650                 655     


Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala Gly His Asp Asn Asn 
            660                 665                 670         


Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser Leu Asn Glu Leu Gly 
        675                 680                 685             


Glu Arg Gln Leu Val His Val Val Lys Trp Ala Lys Ala Leu Pro Gly 
    690                 695                 700                 


Phe Arg Asn Leu His Val Asp Asp Gln Met Ala Val Ile Gln Tyr Ser 
705                 710                 715                 720 


Trp Met Gly Leu Met Val Phe Ala Met Gly Trp Arg Ser Phe Thr Asn 
                725                 730                 735     


Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp Leu Val Phe Asn Glu 
            740                 745                 750         


Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln Cys Val Arg Met Arg 
        755                 760                 765             


His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile Thr Pro Gln Glu Phe 
    770                 775                 780                 


Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile Ile Pro Val Asp Gly 
785                 790                 795                 800 


Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg Met Asn Tyr Ile Lys 
                805                 810                 815     


Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys Asn Pro Thr Ser Cys 
            820                 825                 830         


Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser Val Gln Pro 
        835                 840                 845             


Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp Leu Leu Ile Lys Ser 
    850                 855                 860                 


His Met Val Ser Val Asp Phe Pro Glu Met Met Ala Glu Ile Ile Ser 
865                 870                 875                 880 


Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val Lys Pro Ile Tyr Phe 
                885                 890                 895     


His Thr Gln 
            


<210>  8
<211>  907
<212>  PRT
<213>  Canis familiaris

<400>  8

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Val Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala His Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Glu Thr Ser Pro Arg Gln Gln Gln Gln Gln Gln Gln Gly Asp Asp Gly 
65                  70                  75                  80  


Ser Pro Gln Ala Gln Ser Arg Gly Pro Thr Gly Tyr Leu Ala Leu Asp 
                85                  90                  95      


Glu Glu Gln Gln Pro Ser Gln Gln Arg Ser Ala Ser Lys Gly His Pro 
            100                 105                 110         


Glu Ser Ala Cys Val Pro Glu Pro Gly Val Thr Ser Ala Thr Gly Lys 
        115                 120                 125             


Gly Leu Gln Gln Gln Gln Pro Ala Pro Pro Asp Glu Asn Asp Ser Ala 
    130                 135                 140                 


Ala Pro Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser 
145                 150                 155                 160 


Ser Cys Ser Thr Asp Leu Lys Asp Ile Leu Ser Glu Ala Gly Thr Met 
                165                 170                 175     


Gln Leu Leu Gln Gln Gln Arg Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            180                 185                 190         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu Val Val Ser Glu Gly 
        195                 200                 205             


Ser Ser Ser Gly Arg Ala Arg Glu Ala Ala Gly Ala Ser Thr Ser Ser 
    210                 215                 220                 


Lys Asp Ser Tyr Leu Gly Gly Ser Ser Thr Ile Ser Asp Ser Ala Lys 
225                 230                 235                 240 


Glu Leu Cys Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala 
                245                 250                 255     


Leu Glu His Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr 
            260                 265                 270         


Ala Pro Leu Leu Gly Gly Pro Pro Ala Val Arg Pro Cys Ala Pro Leu 
        275                 280                 285             


Ala Glu Cys Lys Gly Ser Leu Leu Asp Asp Gly Pro Gly Lys Gly Thr 
    290                 295                 300                 


Glu Glu Thr Ala Glu Tyr Ser Pro Phe Lys Ala Gly Tyr Ala Lys Gly 
305                 310                 315                 320 


Leu Asp Gly Asp Ser Leu Gly Cys Ser Ser Ser Ser Glu Ala Gly Gly 
                325                 330                 335     


Ser Gly Thr Leu Glu Met Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly 
            340                 345                 350         


Ala Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe 
        355                 360                 365             


Pro Leu Ser Leu Gly Gly Pro Pro Pro His Pro Pro Pro Pro His Pro 
    370                 375                 380                 


His Thr Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp 
385                 390                 395                 400 


Ala Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His 
                405                 410                 415     


Gly Ala Gly Ala Ala Gly Pro Ser Ser Gly Ser Pro Ser Ala Thr Thr 
            420                 425                 430         


Ser Ser Ser Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr 
        435                 440                 445             


Gly Pro Cys Gly Gly Ser Gly Gly Gly Ser Ala Gly Asp Gly Gly Ser 
    450                 455                 460                 


Val Ala Pro Tyr Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln 
465                 470                 475                 480 


Glu Gly Asp Phe Pro Pro Pro Asp Val Trp Tyr Pro Gly Gly Val Val 
                485                 490                 495     


Ser Arg Val Pro Phe Pro Ser Pro Ser Cys Val Lys Ser Glu Met Gly 
            500                 505                 510         


Ser Trp Met Glu Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu 
        515                 520                 525             


Thr Ala Arg Asp His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln 
    530                 535                 540                 


Lys Thr Cys Leu Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly 
545                 550                 555                 560 


Ala Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu 
                565                 570                 575     


Gly Lys Gln Lys Tyr Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp 
            580                 585                 590         


Lys Phe Arg Arg Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr 
        595                 600                 605             


Glu Ala Gly Met Thr Leu Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn 
    610                 615                 620                 


Leu Lys Leu Gln Glu Glu Gly Glu Ala Ser Asn Val Thr Ser Pro Thr 
625                 630                 635                 640 


Glu Glu Pro Thr Gln Lys Leu Thr Val Ser His Ile Glu Gly Tyr Glu 
                645                 650                 655     


Cys Gln Pro Ile Phe Leu Asn Val Leu Glu Ala Ile Glu Pro Gly Val 
            660                 665                 670         


Val Cys Ala Gly His Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu 
        675                 680                 685             


Leu Ser Ser Leu Asn Glu Leu Gly Glu Arg Gln Leu Val His Val Val 
    690                 695                 700                 


Lys Trp Ala Lys Ala Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp 
705                 710                 715                 720 


Gln Met Ala Val Ile Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala 
                725                 730                 735     


Met Gly Trp Arg Ser Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe 
            740                 745                 750         


Ala Pro Asp Leu Val Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met 
        755                 760                 765             


Tyr Ser Gln Cys Val Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp 
    770                 775                 780                 


Leu Gln Ile Thr Pro Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu 
785                 790                 795                 800 


Phe Ser Ile Ile Pro Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp 
                805                 810                 815     


Glu Leu Arg Met Asn Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys 
            820                 825                 830         


Lys Arg Lys Asn Pro Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr 
        835                 840                 845             


Lys Leu Leu Asp Ser Val Gln Pro Ile Ala Arg Glu Leu His Gln Phe 
    850                 855                 860                 


Thr Phe Asp Leu Leu Ile Lys Ser His Met Val Ser Val Asp Phe Pro 
865                 870                 875                 880 


Glu Met Met Ala Glu Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser 
                885                 890                 895     


Gly Lys Val Lys Pro Ile Tyr Phe His Thr Gln 
            900                 905         


<210>  9
<211>  912
<212>  PRT
<213>  Crocuta crocuta

<400>  9

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Thr Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Arg Leu Gln Gln Gln His Gln His Gln Gln Gln His 
    50                  55                  60                  


Gln His Glu Thr Ser Pro Arg Arg Gln Gln Gln Gln Gln Pro Glu Asp 
65                  70                  75                  80  


Gly Ser Pro Gln Arg Pro Ser Arg Gly Pro Thr Ser Tyr Leu Ala Leu 
                85                  90                  95      


Asp Glu Glu Gln Gln Pro Ser Gln His Gln Ser Ala Lys Gly His Pro 
            100                 105                 110         


Glu Ser Gly Cys Val Pro Glu Pro Val Ala Met Ser Arg Thr Gly Lys 
        115                 120                 125             


Gly Leu Glu Gln Gln Gln Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala 
    130                 135                 140                 


Ala Pro Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser 
145                 150                 155                 160 


Ser Cys Ser Thr Asp Leu Lys Asp Ile Leu Ser Glu Ala Gly Thr Met 
                165                 170                 175     


Gln Leu Leu Gln Arg Gln Arg Gln Arg Gln Gln Gln Arg Gln Gln Gln 
            180                 185                 190         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu 
        195                 200                 205             


Val Val Ser Glu Gly Gly Ser Ser Gly Arg Ala Arg Glu Ala Ala Gly 
    210                 215                 220                 


Ala Pro Thr Ser Ser Lys Asp Ser Tyr Leu Gly Gly Ser Ser Thr Ile 
225                 230                 235                 240 


Ser Asp Ser Ala Lys Glu Leu Cys Lys Ala Val Ser Val Ser Met Gly 
                245                 250                 255     


Leu Gly Val Glu Ala Leu Glu His Leu Ser Pro Gly Glu Gln Leu Arg 
            260                 265                 270         


Gly Asp Cys Met Tyr Ala Pro Leu Leu Gly Gly Pro Pro Pro Val Cys 
        275                 280                 285             


Pro Cys Ala Pro Leu Thr Glu Cys Lys Gly Ser Val Leu Asp Asp Gly 
    290                 295                 300                 


Pro Ser Lys Gly Thr Glu Glu Thr Ala Glu Tyr Ser Pro Phe Lys Thr 
305                 310                 315                 320 


Gly Tyr Ala Lys Gly Leu Asp Gly Asp Ser Leu Gly Cys Ser Gly Ser 
                325                 330                 335     


Ser Gln Ala Gly Gly Ser Gly Thr Leu Glu Ile Pro Ser Thr Leu Ser 
            340                 345                 350         


Leu Tyr Lys Ser Gly Thr Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg 
        355                 360                 365             


Asp Tyr Tyr Asn Phe Gln Leu Ser Leu Ala Gly Pro Pro Pro Pro Pro 
    370                 375                 380                 


Pro Ser Pro His Pro His Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp 
385                 390                 395                 400 


Tyr Gly Ser Ala Trp Ala Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp 
                405                 410                 415     


Leu Ala Ser Leu His Gly Gly Gly Ala Ala Gly Pro Gly Ser Gly Ser 
            420                 425                 430         


Pro Ser Ala Thr Ala Ser Ser Ser Trp His Thr Leu Phe Thr Ala Glu 
        435                 440                 445             


Glu Gly Gln Leu Tyr Gly Pro Cys Gly Gly Ser Gly Gly Gly Gly Thr 
    450                 455                 460                 


Gly Glu Ser Val Ser Val Thr Pro Tyr Gly Tyr Thr Arg Pro Gln Gln 
465                 470                 475                 480 


Gly Leu Thr Gly Gln Glu Gly Asp Phe Pro Pro Pro Asp Val Trp Tyr 
                485                 490                 495     


Pro Gly Gly Val Val Ser Arg Met Pro Tyr Pro Ser Ala Ser Cys Val 
            500                 505                 510         


Lys Ser Glu Met Gly Pro Trp Met Glu Ser Tyr Ser Gly Pro Tyr Gly 
        515                 520                 525             


Asp Met Arg Leu Glu Thr Thr Arg Asp His Val Leu Pro Ile Asp Tyr 
    530                 535                 540                 


Tyr Phe Pro Pro Gln Lys Thr Cys Leu Ile Cys Gly Asp Glu Ala Ser 
545                 550                 555                 560 


Gly Cys His Tyr Gly Ala Leu Thr Cys Gly Ser Cys Lys Val Phe Phe 
                565                 570                 575     


Lys Arg Ala Ala Glu Gly Lys Gln Lys Tyr Leu Cys Ala Ser Arg Asn 
            580                 585                 590         


Asp Cys Thr Ile Asp Lys Phe Arg Arg Lys Asn Cys Pro Pro Cys Arg 
        595                 600                 605             


Leu Arg Lys Cys Tyr Glu Ala Gly Met Thr Leu Gly Ala Arg Arg Leu 
    610                 615                 620                 


Lys Lys Leu Gly Asn Leu Lys Leu Gln Glu Glu Gly Glu Ala Ser Ser 
625                 630                 635                 640 


Thr Thr Ser Pro Thr Glu Glu Thr Thr Gln Lys Leu Thr Val Ser His 
                645                 650                 655     


Ile Glu Gly Tyr Glu Cys Gln Pro Ile Phe Leu Asn Val Leu Glu Ala 
            660                 665                 670         


Ile Glu Pro Gly Val Val Cys Ala Gly His Asp Asn Asn Gln Pro Asp 
        675                 680                 685             


Ser Phe Ala Ala Leu Leu Ser Ser Leu Asn Glu Leu Gly Glu Arg Gln 
    690                 695                 700                 


Leu Val His Val Val Lys Trp Ala Lys Ala Leu Pro Gly Phe Arg Asn 
705                 710                 715                 720 


Leu His Val Asp Asp Gln Met Ala Val Ile Gln Tyr Ser Trp Met Gly 
                725                 730                 735     


Leu Met Val Phe Ala Met Gly Trp Arg Ser Phe Thr Asn Val Asn Ser 
            740                 745                 750         


Arg Met Leu Tyr Phe Ala Pro Asp Leu Val Phe Asn Glu Tyr Arg Met 
        755                 760                 765             


His Lys Ser Arg Met Tyr Ser Gln Cys Val Arg Met Arg His Leu Ser 
    770                 775                 780                 


Gln Glu Phe Gly Trp Leu Gln Ile Thr Pro Gln Glu Phe Leu Cys Met 
785                 790                 795                 800 


Lys Ala Leu Leu Leu Phe Ser Ile Ile Pro Val Asp Gly Leu Lys Asn 
                805                 810                 815     


Gln Lys Phe Phe Asp Glu Leu Arg Met Asn Tyr Ile Lys Asp Leu Asp 
            820                 825                 830         


Arg Ile Ile Ala Cys Lys Arg Lys Asn Pro Thr Ser Cys Ser Arg Arg 
        835                 840                 845             


Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser Val Gln Pro Ile Ala Arg 
    850                 855                 860                 


Glu Leu His Gln Phe Thr Phe Asp Leu Leu Ile Lys Ser His Met Val 
865                 870                 875                 880 


Ser Val Asp Phe Pro Glu Met Met Ala Glu Ile Ile Ser Val Gln Val 
                885                 890                 895     


Pro Lys Ile Leu Ser Gly Lys Val Lys Pro Ile Tyr Phe His Thr Gln 
            900                 905                 910         


<210>  10
<211>  884
<212>  PRT
<213>  Eulemur fulvus

<400>  10

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Arg Leu Gln Gln Gln Gln Glu Thr Ser Pro Pro Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser Pro Gln Ala Gln Ser 
65                  70                  75                  80  


Arg Gly Pro Thr Gly Tyr Leu Ala Leu Asp Glu Glu Gln Gln Pro Ser 
                85                  90                  95      


Gln Gln Gln Ser Ala Leu Glu Cys His Pro Glu Ser Gly Cys Val Pro 
            100                 105                 110         


Glu Pro Gly Ala Ala Ala Ala Ala Ser Lys Gly Leu Gln Gln Gln Pro 
        115                 120                 125             


Pro Ala Pro Ser Asp Glu Asp Asp Ser Ala Val Pro Ser Thr Leu Ser 
    130                 135                 140                 


Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser Cys Ser Ala Asp Leu 
145                 150                 155                 160 


Lys Asp Ile Leu Ser Glu Ala Gly Thr Met Gln Leu Leu Gln Gln Gln 
                165                 170                 175     


Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser Gly Arg Ala Arg Glu 
            180                 185                 190         


Ala Ala Gly Ala Pro Thr Ser Ser Lys Asp Ser Tyr Leu Gly Gly Thr 
        195                 200                 205             


Ser Thr Ile Ser Asp Ser Ala Lys Glu Leu Cys Lys Ala Val Ser Val 
    210                 215                 220                 


Ser Met Gly Leu Gly Val Glu Thr Leu Glu His Leu Ser Pro Gly Glu 
225                 230                 235                 240 


Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu Leu Gly Gly Pro Pro 
                245                 250                 255     


Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala Glu Cys Lys Gly Ser 
            260                 265                 270         


Leu Leu Asp Asp Ser Ala Asp Lys Gly Thr Glu Glu Pro Ala Glu Tyr 
        275                 280                 285             


Thr Pro Phe Lys Gly Ser Tyr Thr Gln Gly Leu Glu Gly Glu Ser Leu 
    290                 295                 300                 


Gly Cys Ser Gly Ser Ser Glu Ala Gly Ser Ser Gly Thr Leu Glu Leu 
305                 310                 315                 320 


Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala Leu Glu Glu Ala Ala 
                325                 330                 335     


Ser Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro Leu Ala Leu Ala Gly 
            340                 345                 350         


Pro Pro Pro Pro Pro Leu Pro Pro His Pro His Ala Arg Ile Lys Leu 
        355                 360                 365             


Glu Asn Pro Leu Asp Tyr Gly Ser Ser Trp Ala Ala Ala Ala Ala Gln 
    370                 375                 380                 


Cys Arg Phe Gly Asp Leu Ala Ser Leu His Gly Gly Gly Ala Thr Gly 
385                 390                 395                 400 


Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ala Ser Ser Trp His Thr 
                405                 410                 415     


Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly Pro Cys Gly Gly Gly 
            420                 425                 430         


Gly Gly Gly Thr Ser Glu Ala Gly Ala Val Thr Pro Tyr Gly Tyr Ser 
        435                 440                 445             


Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Gly Asp Phe Pro Ala Pro 
    450                 455                 460                 


Asp Val Trp Tyr Pro Ser Gly Val Val Ser Arg Val Pro Tyr Pro Ser 
465                 470                 475                 480 


Pro Ser Cys Val Lys Ser Glu Met Gly Pro Trp Met Glu Ser Tyr Ser 
                485                 490                 495     


Gly Pro Tyr Gly Asp Val Arg Leu Glu Thr Ala Arg Asp His Val Leu 
            500                 505                 510         


Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys Leu Ile Cys Gly 
        515                 520                 525             


Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr Cys Gly Ser Cys 
    530                 535                 540                 


Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln Lys Tyr Leu Cys 
545                 550                 555                 560 


Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg Arg Lys Asn Cys 
                565                 570                 575     


Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly Met Thr Leu Gly 
            580                 585                 590         


Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu Gln Glu Glu Gly 
        595                 600                 605             


Glu Ala Ser Ser Ala Thr Ser Pro Thr Glu Glu Ser Ser Gln Lys Leu 
    610                 615                 620                 


Thr Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro Ile Phe Leu Asn 
625                 630                 635                 640 


Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala Gly His Asp Asn 
                645                 650                 655     


Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser Leu Asn Glu Leu 
            660                 665                 670         


Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala Lys Ala Leu Pro 
        675                 680                 685             


Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala Val Ile Gln Tyr 
    690                 695                 700                 


Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp Arg Ser Phe Thr 
705                 710                 715                 720 


Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp Leu Val Phe Asn 
                725                 730                 735     


Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln Cys Val Arg Met 
            740                 745                 750         


Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile Thr Pro Gln Glu 
        755                 760                 765             


Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile Ile Pro Val Asp 
    770                 775                 780                 


Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg Met Asn Tyr Ile 
785                 790                 795                 800 


Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys Asn Pro Thr Ser 
                805                 810                 815     


Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser Val Gln 
            820                 825                 830         


Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp Leu Leu Ile Lys 
        835                 840                 845             


Ser His Met Val Ser Val Asp Phe Pro Glu Met Met Ala Glu Ile Ile 
    850                 855                 860                 


Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val Lys Pro Ile Tyr 
865                 870                 875                 880 


Phe His Thr Gln 
                


<210>  11
<211>  777
<212>  PRT
<213>  Lithobates catesbeiana

<400>  11

Met Glu Val His Ile Gly Leu Gly Gly Val Tyr Lys Gln Pro Pro Gly 
1               5                   10                  15      


Lys Met Ile Arg Gly Ala Phe Glu Asn Leu Phe Leu Ser Val Arg Glu 
            20                  25                  30          


Ala Leu Gln Gly Glu Arg Arg Ser Ala Ala Ser Leu Asp Thr Ser Ser 
        35                  40                  45              


Pro Ile Ser Ala Cys Val His Pro His Pro Thr Trp Asn Glu Pro Ser 
    50                  55                  60                  


Thr Trp Thr Glu Val Arg Gly Thr Pro Trp Arg Glu Pro Gln Gly Ala 
65                  70                  75                  80  


Gln Pro Asp Pro Pro Pro Cys Ser Pro Arg Ser Gln Ala Pro Gln Phe 
                85                  90                  95      


Thr Leu Ser Ser Cys Thr Thr Glu Leu Lys Glu Ile Leu Gly Glu Gln 
            100                 105                 110         


Gly Gly Met Pro Glu Glu Gly Asn Ser Glu Ser Ala Ser Lys Glu Gly 
        115                 120                 125             


Tyr Pro Glu Ser Ile Ser Asp Ser Ala Lys Glu Ile Cys Lys Ala Val 
    130                 135                 140                 


Ser Val Ser Leu Gly Leu Ser Met Glu Ala Leu Glu His Leu Ser Ala 
145                 150                 155                 160 


Ala Gly Glu Trp Gln Arg Gly Asp Cys Met Phe Ala Gly Pro Pro His 
                165                 170                 175     


His Thr Met Gly Ala Gln Thr Cys Gln Val Ala Glu Glu Asp Lys Ser 
            180                 185                 190         


Asp Thr Ser Phe Ser Gln Tyr Arg Glu Gly Ala Phe Arg Arg Ala Gly 
        195                 200                 205             


Gln Ser Thr Tyr Ser Ala Gly Lys Ala Pro Glu Asp Gly Ser Ser Leu 
    210                 215                 220                 


Pro Thr Glu Asp Lys Glu Gln Pro Cys Thr Asp Met Ala Leu Ser Glu 
225                 230                 235                 240 


Pro Gly Ser Leu Arg Ser Arg Gly Met Glu Val Met Pro Ser Leu Thr 
                245                 250                 255     


Leu Tyr Lys Pro Thr Ala Phe Met Glu Asp Ala Ser Ala Tyr Pro Gly 
            260                 265                 270         


Arg Asp Tyr Tyr Ser Phe Gln Met Ala Leu Ala Pro His Gly Arg Ile 
        275                 280                 285             


Lys Val Glu Ser Pro Ile Glu Phe Ala Gly Ser Ala Trp Gly Gly Pro 
    290                 295                 300                 


Ser Arg Tyr Ser Glu Phe Pro Gly Phe Ser His Cys Gly Pro Ser Ala 
305                 310                 315                 320 


Asn Trp His Ser Leu Phe Glu Glu Gly Gln Ala Thr Ala Ser Tyr Thr 
                325                 330                 335     


Asp Ser Ser Leu Tyr Ser Tyr Pro Arg Ser His Val Pro Ala Gly Pro 
            340                 345                 350         


Asp Gly Glu Phe Ser Ala Glu Ala Trp Tyr Pro Ala Thr Ala Met Leu 
        355                 360                 365             


Gly Arg Val His Met Ala Val Pro Met Arg Pro Arg Met Thr His Gly 
    370                 375                 380                 


Trp Thr Ala Thr Leu Gly Ile Arg Arg Arg Leu Gly Trp Thr Gly Val 
385                 390                 395                 400 


Glu Ser Thr Phe Tyr Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Pro 
                405                 410                 415     


Cys Leu Ser Cys Glu Asp Glu Ala Ser Gly Cys His Tyr Glu Ala Leu 
            420                 425                 430         


Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Asn 
        435                 440                 445             


Gln Lys Tyr Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe 
    450                 455                 460                 


Arg Arg Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala 
465                 470                 475                 480 


Gly Met Thr Leu Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys 
                485                 490                 495     


Ala Gln Glu Glu Leu Glu Gly Ser Pro Gly Gln Ser Glu Gly Arg Glu 
            500                 505                 510         


Met Pro Pro Asn Met Ser Ile Pro Gln Leu Glu Gly Tyr Ser Cys Gln 
        515                 520                 525             


Pro Ile Phe Leu Asn Val Leu Glu Ala Ile Glu Pro Met Val Val Cys 
    530                 535                 540                 


Ser Gly His Asp Asn Asn Gln Pro Asp Ser Phe Ala Leu Leu Leu Ser 
545                 550                 555                 560 


Ser Leu Asn Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp 
                565                 570                 575     


Ala Lys Ala Leu Pro Gly Phe Arg Asn Leu His Val Asn Asp Gln Met 
            580                 585                 590         


Thr Val Ile Gln Tyr Ser Trp Met Gly Leu Met Ile Phe Ala Met Gly 
        595                 600                 605             


Trp Arg Ser Phe Lys Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro 
    610                 615                 620                 


Asp Leu Val Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser 
625                 630                 635                 640 


Gln Cys Val Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln 
                645                 650                 655     


Val Thr Pro Glu Glu Phe Leu Cys Asp Glu Gly Pro Ser Ala Leu Ser 
            660                 665                 670         


Ile Ile Pro Val Glu Gly Leu Lys Asp Gln Lys Cys Phe Asp Glu Leu 
        675                 680                 685             


Arg Met Asn Tyr Ile Lys Glu Leu Asp Arg Val Ile Ser Cys Lys Arg 
    690                 695                 700                 


Asn Asn Pro Ala Ser Ser Ser Pro Arg Phe Phe Asn Leu Pro Lys Leu 
705                 710                 715                 720 


Leu Gly Ser Val Gln Pro Ile Asp Val Asn Leu Val Gln Phe Thr Phe 
                725                 730                 735     


Gly Leu Phe Gly Lys Ala Gln Met Val Ser Val Asp Phe Pro Glu Met 
            740                 745                 750         


Met Ser Glu Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Arg 
        755                 760                 765             


Val Lys Pro Leu Tyr Phe His Ser Ser 
    770                 775         


<210>  12
<211>  895
<212>  PRT
<213>  Macaca fascicularis

<400>  12

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Gln Gln Gln Gln Gln Gln Gln Gln Glu Thr 
    50                  55                  60                  


Ser Pro Arg Gln Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser Pro 
65                  70                  75                  80  


Gln Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu Glu 
                85                  90                  95      


Gln Gln Pro Ser Gln Pro Gln Ser Ala Pro Glu Cys His Pro Glu Arg 
            100                 105                 110         


Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Gly Lys Gly Leu 
        115                 120                 125             


Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala Pro 
    130                 135                 140                 


Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser Cys 
145                 150                 155                 160 


Ser Thr Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln Leu 
                165                 170                 175     


Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser Gly 
            180                 185                 190         


Arg Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn Tyr 
        195                 200                 205             


Leu Gly Gly Thr Ser Thr Ile Ser Asp Ser Ala Lys Glu Leu Cys Lys 
    210                 215                 220                 


Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His Leu 
225                 230                 235                 240 


Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Val Leu 
                245                 250                 255     


Gly Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala Glu 
            260                 265                 270         


Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu Asp 
        275                 280                 285             


Thr Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu Glu 
    290                 295                 300                 


Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser Gly 
305                 310                 315                 320 


Thr Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala Leu 
                325                 330                 335     


Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro Leu 
            340                 345                 350         


Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His Ala 
        355                 360                 365             


Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala Ala 
    370                 375                 380                 


Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly Ala 
385                 390                 395                 400 


Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser Ser 
                405                 410                 415     


Ser Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly Pro 
            420                 425                 430         


Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly 
        435                 440                 445             


Glu Ala Gly Ala Val Ala Pro Tyr Gly Tyr Thr Arg Pro Pro Gln Gly 
    450                 455                 460                 


Leu Ala Gly Gln Glu Gly Asp Phe Thr Ala Pro Asp Val Trp Tyr Pro 
465                 470                 475                 480 


Gly Gly Met Val Ser Arg Val Pro Tyr Pro Ser Pro Thr Cys Val Lys 
                485                 490                 495     


Ser Glu Met Gly Pro Trp Met Asp Ser Tyr Ser Gly Pro Tyr Gly Asp 
            500                 505                 510         


Met Arg Leu Glu Thr Ala Arg Asp His Val Leu Pro Ile Asp Tyr Tyr 
        515                 520                 525             


Phe Pro Pro Gln Lys Thr Cys Leu Ile Cys Gly Asp Glu Ala Ser Gly 
    530                 535                 540                 


Cys His Tyr Gly Ala Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys 
545                 550                 555                 560 


Arg Ala Ala Glu Gly Lys Gln Lys Tyr Leu Cys Ala Ser Arg Asn Asp 
                565                 570                 575     


Cys Thr Ile Asp Lys Phe Arg Arg Lys Asn Cys Pro Ser Cys Arg Leu 
            580                 585                 590         


Arg Lys Cys Tyr Glu Ala Gly Met Thr Leu Gly Ala Arg Lys Leu Lys 
        595                 600                 605             


Lys Leu Gly Asn Leu Lys Leu Gln Glu Glu Gly Glu Ala Ser Ser Thr 
    610                 615                 620                 


Thr Ser Pro Thr Glu Glu Thr Ala Gln Lys Leu Thr Val Ser His Ile 
625                 630                 635                 640 


Glu Gly Tyr Glu Cys Gln Pro Ile Phe Leu Asn Val Leu Glu Ala Ile 
                645                 650                 655     


Glu Pro Gly Val Val Cys Ala Gly His Asp Asn Asn Gln Pro Asp Ser 
            660                 665                 670         


Phe Ala Ala Leu Leu Ser Ser Leu Asn Glu Leu Gly Glu Arg Gln Leu 
        675                 680                 685             


Val His Val Val Lys Trp Ala Lys Ala Leu Pro Gly Phe Arg Asn Leu 
    690                 695                 700                 


His Val Asp Asp Gln Met Ala Val Ile Gln Tyr Ser Trp Met Gly Leu 
705                 710                 715                 720 


Met Val Phe Ala Met Gly Trp Arg Ser Phe Thr Asn Val Asn Ser Arg 
                725                 730                 735     


Met Leu Tyr Phe Ala Pro Asp Leu Val Phe Asn Glu Tyr Arg Met His 
            740                 745                 750         


Lys Ser Arg Met Tyr Ser Gln Cys Val Arg Met Arg His Leu Ser Gln 
        755                 760                 765             


Glu Phe Gly Trp Leu Gln Ile Thr Pro Gln Glu Phe Leu Cys Met Lys 
    770                 775                 780                 


Ala Leu Leu Leu Phe Ser Ile Ile Pro Val Asp Gly Leu Lys Asn Gln 
785                 790                 795                 800 


Lys Phe Phe Asp Glu Leu Arg Met Asn Tyr Ile Lys Glu Leu Asp Arg 
                805                 810                 815     


Ile Ile Ala Cys Lys Arg Lys Asn Pro Thr Ser Cys Ser Arg Arg Phe 
            820                 825                 830         


Tyr Gln Leu Thr Lys Leu Leu Asp Ser Val Gln Pro Ile Ala Arg Glu 
        835                 840                 845             


Leu His Gln Phe Thr Phe Asp Leu Leu Ile Lys Ser His Met Val Ser 
    850                 855                 860                 


Val Asp Phe Pro Glu Met Met Ala Glu Ile Ile Ser Val Gln Val Pro 
865                 870                 875                 880 


Lys Ile Leu Ser Gly Lys Val Lys Pro Ile Tyr Phe His Thr Gln 
                885                 890                 895 


<210>  13
<211>  895
<212>  PRT
<213>  Macaca mulatta

<400>  13

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Gln Gln Gln Gln Gln Gln Gln Gln Glu Thr 
    50                  55                  60                  


Ser Pro Arg Gln Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser Pro 
65                  70                  75                  80  


Gln Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu Glu 
                85                  90                  95      


Gln Gln Pro Ser Gln Pro Gln Ser Ala Pro Glu Cys His Pro Glu Arg 
            100                 105                 110         


Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Gly Lys Gly Leu 
        115                 120                 125             


Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala Pro 
    130                 135                 140                 


Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser Cys 
145                 150                 155                 160 


Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln Leu 
                165                 170                 175     


Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser Gly 
            180                 185                 190         


Arg Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn Tyr 
        195                 200                 205             


Leu Glu Gly Thr Ser Thr Ile Ser Asp Ser Ala Lys Glu Leu Cys Lys 
    210                 215                 220                 


Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His Leu 
225                 230                 235                 240 


Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Val Leu 
                245                 250                 255     


Gly Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala Glu 
            260                 265                 270         


Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu Asp 
        275                 280                 285             


Thr Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu Glu 
    290                 295                 300                 


Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser Gly 
305                 310                 315                 320 


Thr Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala Leu 
                325                 330                 335     


Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro Leu 
            340                 345                 350         


Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His Ala 
        355                 360                 365             


Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala Ala 
    370                 375                 380                 


Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly Ala 
385                 390                 395                 400 


Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser Ser 
                405                 410                 415     


Ser Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly Pro 
            420                 425                 430         


Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly 
        435                 440                 445             


Glu Ala Gly Ala Val Ala Pro Tyr Gly Tyr Thr Arg Pro Pro Gln Gly 
    450                 455                 460                 


Leu Ala Gly Gln Glu Gly Asp Phe Thr Ala Pro Asp Val Trp Tyr Pro 
465                 470                 475                 480 


Gly Gly Met Val Ser Arg Val Pro Tyr Pro Ser Pro Thr Cys Val Lys 
                485                 490                 495     


Ser Glu Met Gly Pro Trp Met Asp Ser Tyr Ser Gly Pro Tyr Gly Asp 
            500                 505                 510         


Met Arg Leu Glu Thr Ala Arg Asp His Val Leu Pro Ile Asp Tyr Tyr 
        515                 520                 525             


Phe Pro Pro Gln Lys Thr Cys Leu Ile Cys Gly Asp Glu Ala Ser Gly 
    530                 535                 540                 


Cys His Tyr Gly Ala Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys 
545                 550                 555                 560 


Arg Ala Ala Glu Gly Lys Gln Lys Tyr Leu Cys Ala Ser Arg Asn Asp 
                565                 570                 575     


Cys Thr Ile Asp Lys Phe Arg Arg Lys Asn Cys Pro Ser Cys Arg Leu 
            580                 585                 590         


Arg Lys Cys Tyr Glu Ala Gly Met Thr Leu Gly Ala Arg Lys Leu Lys 
        595                 600                 605             


Lys Leu Gly Asn Leu Lys Leu Gln Glu Glu Gly Glu Ala Ser Ser Thr 
    610                 615                 620                 


Thr Ser Pro Thr Glu Glu Thr Ala Gln Lys Leu Thr Val Ser His Ile 
625                 630                 635                 640 


Glu Gly Tyr Glu Cys Gln Pro Ile Phe Leu Asn Val Leu Glu Ala Ile 
                645                 650                 655     


Glu Pro Gly Val Val Cys Ala Gly His Asp Asn Asn Gln Pro Asp Ser 
            660                 665                 670         


Phe Ala Ala Leu Leu Ser Ser Leu Asn Glu Leu Gly Glu Arg Gln Leu 
        675                 680                 685             


Val His Val Val Lys Trp Ala Lys Ala Leu Pro Gly Phe Arg Asn Leu 
    690                 695                 700                 


His Val Asp Asp Gln Met Ala Val Ile Gln Tyr Ser Trp Met Gly Leu 
705                 710                 715                 720 


Met Val Phe Ala Met Gly Trp Arg Ser Phe Thr Asn Val Asn Ser Arg 
                725                 730                 735     


Met Leu Tyr Phe Ala Pro Asp Leu Val Phe Asn Glu Tyr Arg Met His 
            740                 745                 750         


Lys Ser Arg Met Tyr Ser Gln Cys Val Arg Met Arg His Leu Ser Gln 
        755                 760                 765             


Glu Phe Gly Trp Leu Gln Ile Thr Pro Gln Glu Phe Leu Cys Met Lys 
    770                 775                 780                 


Ala Leu Leu Leu Phe Ser Ile Ile Pro Val Asp Gly Leu Lys Asn Gln 
785                 790                 795                 800 


Lys Phe Phe Asp Glu Leu Arg Met Asn Tyr Ile Lys Glu Leu Asp Arg 
                805                 810                 815     


Ile Ile Ala Cys Lys Arg Lys Asn Pro Thr Ser Cys Ser Arg Arg Phe 
            820                 825                 830         


Tyr Gln Leu Thr Lys Leu Leu Asp Ser Val Gln Pro Ile Ala Arg Glu 
        835                 840                 845             


Leu His Gln Phe Thr Phe Asp Leu Leu Ile Lys Ser His Met Val Ser 
    850                 855                 860                 


Val Asp Phe Pro Glu Met Met Ala Glu Ile Ile Ser Val Gln Val Pro 
865                 870                 875                 880 


Lys Ile Leu Ser Gly Lys Val Lys Pro Ile Tyr Phe His Thr Gln 
                885                 890                 895 


<210>  14
<211>  911
<212>  PRT
<213>  Pan troglodyte

<400>  14

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu Thr 
65                  70                  75                  80  


Ser Pro Arg Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser Pro Gln Ala 
                85                  90                  95      


His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu Glu Gln Gln 
            100                 105                 110         


Pro Ser Gln Pro Gln Ser Ala Pro Glu Cys His Pro Glu Arg Gly Cys 
        115                 120                 125             


Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly Leu Pro Gln 
    130                 135                 140                 


Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala Pro Ser Thr 
145                 150                 155                 160 


Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser Cys Ser Ala 
                165                 170                 175     


Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln Leu Leu Gln 
            180                 185                 190         


Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser Gly Arg Ala 
        195                 200                 205             


Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn Tyr Leu Gly 
    210                 215                 220                 


Gly Thr Ser Thr Ile Ser Asp Ser Ala Lys Glu Leu Cys Lys Ala Val 
225                 230                 235                 240 


Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His Leu Ser Pro 
                245                 250                 255     


Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu Leu Gly Val 
            260                 265                 270         


Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala Glu Cys Lys 
        275                 280                 285             


Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu Asp Thr Ala 
    290                 295                 300                 


Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu Glu Gly Glu 
305                 310                 315                 320 


Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser Gly Thr Leu 
                325                 330                 335     


Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala Leu Asp Glu 
            340                 345                 350         


Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro Leu Ala Leu 
        355                 360                 365             


Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His Ala Arg Ile 
    370                 375                 380                 


Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala Ala Ala Ala 
385                 390                 395                 400 


Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly Ala Gly Ala 
                405                 410                 415     


Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser Ser Ser Trp 
            420                 425                 430         


His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly Pro Cys Gly 
        435                 440                 445             


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Glu Ala Gly Ala Val Ala Pro Tyr Gly Tyr Thr Arg Pro Pro Gln Gly 
465                 470                 475                 480 


Leu Ala Gly Gln Glu Gly Asp Phe Thr Ala Pro Asp Val Trp Tyr Pro 
                485                 490                 495     


Gly Gly Met Val Ser Arg Val Pro Tyr Pro Ser Pro Thr Cys Val Lys 
            500                 505                 510         


Ser Glu Met Gly Pro Trp Met Asp Ser Tyr Ser Gly Pro Tyr Gly Asp 
        515                 520                 525             


Met Arg Leu Glu Thr Ala Arg Asp His Val Leu Pro Ile Asp Tyr Tyr 
    530                 535                 540                 


Phe Pro Pro Gln Lys Thr Cys Leu Ile Cys Gly Asp Glu Ala Ser Gly 
545                 550                 555                 560 


Cys His Tyr Gly Ala Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys 
                565                 570                 575     


Arg Ala Ala Glu Gly Lys Gln Lys Tyr Leu Cys Ala Ser Arg Asn Asp 
            580                 585                 590         


Cys Thr Ile Asp Lys Phe Arg Arg Lys Asn Cys Pro Ser Cys Arg Leu 
        595                 600                 605             


Arg Lys Cys Tyr Glu Ala Gly Met Thr Leu Gly Ala Arg Lys Leu Lys 
    610                 615                 620                 


Lys Leu Gly Asn Leu Lys Leu Gln Glu Glu Gly Glu Ala Ser Ser Thr 
625                 630                 635                 640 


Thr Ser Pro Thr Glu Glu Thr Thr Gln Lys Leu Thr Val Ser His Ile 
                645                 650                 655     


Glu Gly Tyr Glu Cys Gln Pro Ile Phe Leu Asn Val Leu Glu Ala Ile 
            660                 665                 670         


Glu Pro Gly Val Val Cys Ala Gly His Asp Asn Asn Gln Pro Asp Ser 
        675                 680                 685             


Phe Ala Ala Leu Leu Ser Ser Leu Asn Glu Leu Gly Glu Arg Gln Leu 
    690                 695                 700                 


Val His Val Val Lys Trp Ala Lys Ala Leu Pro Gly Phe Arg Asn Leu 
705                 710                 715                 720 


His Val Asp Asp Gln Met Ala Val Ile Gln Tyr Ser Trp Met Gly Leu 
                725                 730                 735     


Met Val Phe Ala Met Gly Trp Arg Ser Phe Thr Asn Val Asn Ser Arg 
            740                 745                 750         


Met Leu Tyr Phe Ala Pro Asp Leu Val Phe Asn Glu Tyr Arg Met His 
        755                 760                 765             


Lys Ser Arg Met Tyr Ser Gln Cys Val Arg Met Arg His Leu Ser Gln 
    770                 775                 780                 


Glu Phe Gly Trp Leu Gln Ile Thr Pro Gln Glu Phe Leu Cys Met Lys 
785                 790                 795                 800 


Ala Leu Leu Leu Phe Ser Ile Ile Pro Val Asp Gly Leu Lys Asn Gln 
                805                 810                 815     


Lys Phe Phe Asp Glu Leu Arg Met Asn Tyr Ile Lys Glu Leu Asp Arg 
            820                 825                 830         


Ile Ile Ala Cys Lys Arg Lys Asn Pro Thr Ser Cys Ser Arg Arg Phe 
        835                 840                 845             


Tyr Gln Leu Thr Lys Leu Leu Asp Ser Val Gln Pro Ile Ala Arg Glu 
    850                 855                 860                 


Leu His Gln Phe Thr Phe Asp Leu Leu Ile Lys Ser His Met Val Ser 
865                 870                 875                 880 


Val Asp Phe Pro Glu Met Met Ala Glu Ile Ile Ser Val Gln Val Pro 
                885                 890                 895     


Lys Ile Leu Ser Gly Lys Val Lys Pro Ile Tyr Phe His Thr Gln 
            900                 905                 910     


<210>  15
<211>  895
<212>  PRT
<213>  Papio hamadryas

<400>  15

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu 
    50                  55                  60                  


Thr Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser Pro 
65                  70                  75                  80  


Gln Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu Glu 
                85                  90                  95      


Gln Gln Pro Ser Gln Pro Gln Ser Ala Pro Glu Cys His Pro Glu Arg 
            100                 105                 110         


Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Gly Lys Gly Leu 
        115                 120                 125             


Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala Pro 
    130                 135                 140                 


Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser Cys 
145                 150                 155                 160 


Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln Leu 
                165                 170                 175     


Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser Gly 
            180                 185                 190         


Arg Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn Tyr 
        195                 200                 205             


Leu Gly Gly Thr Ser Thr Ile Ser Asp Ser Ala Lys Glu Leu Cys Lys 
    210                 215                 220                 


Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His Leu 
225                 230                 235                 240 


Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Val Leu 
                245                 250                 255     


Gly Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala Glu 
            260                 265                 270         


Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu Asp 
        275                 280                 285             


Thr Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu Glu 
    290                 295                 300                 


Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser Gly 
305                 310                 315                 320 


Thr Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala Leu 
                325                 330                 335     


Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro Leu 
            340                 345                 350         


Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His Ala 
        355                 360                 365             


Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala Ala 
    370                 375                 380                 


Ala Ala Ala Gln Cys Arg Tyr Gly Glu Leu Ala Ser Leu His Gly Ala 
385                 390                 395                 400 


Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser Ser 
                405                 410                 415     


Ser Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly Pro 
            420                 425                 430         


Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly 
        435                 440                 445             


Glu Ala Gly Ala Val Ala Pro Tyr Gly Tyr Thr Arg Pro Pro Gln Gly 
    450                 455                 460                 


Leu Ala Gly Gln Glu Gly Asp Phe Thr Ala Pro Asp Val Trp Tyr Pro 
465                 470                 475                 480 


Gly Gly Met Val Ser Arg Val Pro Tyr Pro Ser Pro Thr Cys Val Lys 
                485                 490                 495     


Ser Glu Met Gly Pro Trp Met Asp Ser Tyr Ser Gly Pro Tyr Gly Asp 
            500                 505                 510         


Met Arg Leu Glu Thr Ala Arg Asp His Val Leu Pro Ile Asp Tyr Tyr 
        515                 520                 525             


Phe Pro Pro Gln Lys Thr Cys Leu Ile Cys Gly Asp Glu Ala Ser Gly 
    530                 535                 540                 


Cys His Tyr Gly Ala Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys 
545                 550                 555                 560 


Arg Ala Ala Glu Gly Lys Gln Lys Tyr Leu Cys Ala Ser Arg Asn Asp 
                565                 570                 575     


Cys Thr Ile Asp Lys Phe Arg Arg Lys Asn Cys Pro Ser Cys Arg Leu 
            580                 585                 590         


Arg Lys Cys Tyr Glu Ala Gly Met Thr Leu Gly Ala Arg Lys Leu Lys 
        595                 600                 605             


Lys Leu Gly Asn Leu Lys Leu Gln Glu Glu Gly Glu Ala Ser Ser Thr 
    610                 615                 620                 


Thr Ser Pro Thr Glu Glu Thr Ala Gln Lys Leu Thr Val Ser His Ile 
625                 630                 635                 640 


Glu Gly Tyr Glu Cys Gln Pro Ile Phe Leu Asn Val Leu Glu Ala Ile 
                645                 650                 655     


Glu Pro Gly Val Val Cys Ala Gly His Asp Asn Asn Gln Pro Asp Ser 
            660                 665                 670         


Phe Ala Ala Leu Leu Ser Ser Leu Asn Glu Leu Gly Glu Arg Gln Leu 
        675                 680                 685             


Val His Val Val Lys Trp Ala Lys Ala Leu Pro Gly Phe Arg Asn Leu 
    690                 695                 700                 


His Val Asp Asp Gln Met Ala Val Ile Gln Tyr Ser Trp Met Gly Leu 
705                 710                 715                 720 


Met Val Phe Ala Met Gly Trp Arg Ser Phe Thr Asn Val Asn Ser Arg 
                725                 730                 735     


Met Leu Tyr Phe Ala Pro Asp Leu Val Phe Asn Glu Tyr Arg Met His 
            740                 745                 750         


Lys Ser Arg Met Tyr Ser Gln Cys Val Arg Met Arg His Leu Ser Gln 
        755                 760                 765             


Glu Phe Gly Trp Leu Gln Ile Thr Pro Gln Glu Phe Leu Cys Met Lys 
    770                 775                 780                 


Ala Leu Leu Leu Phe Ser Ile Ile Pro Val Asp Gly Leu Lys Asn Gln 
785                 790                 795                 800 


Lys Phe Phe Asp Glu Leu Arg Met Asn Tyr Ile Lys Glu Leu Asp Arg 
                805                 810                 815     


Ile Ile Ala Cys Lys Arg Lys Asn Pro Thr Ser Cys Ser Arg Arg Phe 
            820                 825                 830         


Tyr Gln Leu Thr Lys Leu Leu Asp Ser Val Gln Pro Ile Ala Arg Glu 
        835                 840                 845             


Leu His Gln Phe Thr Phe Asp Leu Leu Ile Lys Ser His Met Val Ser 
    850                 855                 860                 


Val Asp Phe Pro Glu Met Met Ala Glu Ile Ile Ser Val Gln Val Pro 
865                 870                 875                 880 


Lys Ile Leu Ser Gly Lys Val Lys Pro Ile Tyr Phe His Thr Gln 
                885                 890                 895 


<210>  16
<211>  896
<212>  PRT
<213>  Sus scrofa

<400>  16

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Phe Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Arg Leu Gln Gln Gln Gln Leu Gln Gln Gln Glu Thr 
    50                  55                  60                  


Ser Pro Arg Arg Gln Gln Gln Gln Gln Gln Gln Pro Ser Glu Asp Gly 
65                  70                  75                  80  


Ser Pro Gln Val Gln Ser Arg Gly Pro Thr Gly Tyr Leu Ala Leu Asp 
                85                  90                  95      


Glu Lys Gln Gln Pro Ser Gln Gln Gln Ser Ala Pro Glu Cys His Pro 
            100                 105                 110         


Glu Ser Gly Cys Thr Pro Glu Pro Gly Ala Ala Ser Ala Ala Ser Lys 
        115                 120                 125             


Gly Leu Gln Gln Gln Pro Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala 
    130                 135                 140                 


Ala Pro Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser 
145                 150                 155                 160 


Ser Cys Ser Thr Asp Leu Lys Asp Ile Leu Ser Glu Ala Gly Thr Met 
                165                 170                 175     


Gln Leu Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu Ala Val 
            180                 185                 190         


Ser Glu Gly Asn Ser Ser Gly Arg Ala Arg Glu Ala Thr Gly Ala Pro 
        195                 200                 205             


Ile Ser Ser Lys Asp Ser Tyr Leu Gly Gly Ser Ser Thr Ile Ser Asp 
    210                 215                 220                 


Ser Ala Lys Glu Leu Cys Lys Ala Val Ser Val Ser Met Gly Leu Gly 
225                 230                 235                 240 


Val Glu Ala Leu Glu His Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp 
                245                 250                 255     


Cys Met Tyr Ala Pro Leu Leu Thr Gly Pro Pro Ser Val Arg Pro Thr 
            260                 265                 270         


Pro Cys Ala Pro Leu Ala Glu Cys Lys Gly Ser Leu Leu Asp Asp Gly 
        275                 280                 285             


Pro Gly Lys Ser Asn Glu Glu Thr Ala Glu Tyr Ser Pro Phe Lys Ala 
    290                 295                 300                 


Gly Tyr Thr Lys Gly Leu Asp Ser Glu Ser Leu Gly Cys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ala Gly Gly Ser Gly Thr Leu Glu Leu Pro Ser Ala Leu Ser 
                325                 330                 335     


Leu Tyr Lys Ser Gly Ala Leu Asp Asp Val Ala Ala Tyr Pro Ser Arg 
            340                 345                 350         


Asp Tyr Tyr Asn Phe Pro Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro 
        355                 360                 365             


Pro Pro Pro His Pro His Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp 
    370                 375                 380                 


Tyr Gly Ser Ala Trp Ala Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp 
385                 390                 395                 400 


Leu Ala Ser Leu His Gly Gly Gly Ala Pro Gly Pro Gly Ser Gly Ser 
                405                 410                 415     


Pro Ser Ala Thr Ser Ser Ser Ser Trp His Thr Leu Phe Thr Ala Glu 
            420                 425                 430         


Glu Ser Gln Leu Tyr Gly Pro Cys Gly Gly Gly Gly Gly Gly Ser Ala 
        435                 440                 445             


Gly Glu Ala Gly Ala Val Ala Pro Tyr Gly Tyr Thr Arg Pro Pro Gln 
    450                 455                 460                 


Gly Leu Ala Gly Gln Glu Gly Asp Leu Ala Ile Pro Asp Ile Trp Tyr 
465                 470                 475                 480 


Pro Gly Gly Val Val Ser Arg Val Pro Tyr Pro Ser Pro Ser Cys Val 
                485                 490                 495     


Lys Ser Glu Met Gly Pro Trp Met Glu Ser Tyr Ser Gly Pro Tyr Gly 
            500                 505                 510         


Asp Met Arg Leu Glu Pro Thr Arg Asp His Val Leu Pro Ile Asp Tyr 
        515                 520                 525             


Tyr Phe Pro Pro Gln Lys Thr Cys Leu Ile Cys Gly Asp Glu Ala Ser 
    530                 535                 540                 


Gly Cys His Tyr Gly Ala Leu Thr Cys Gly Ser Cys Lys Val Phe Phe 
545                 550                 555                 560 


Lys Arg Ala Ala Glu Gly Lys Gln Lys Tyr Leu Cys Ala Ser Arg Asn 
                565                 570                 575     


Asp Cys Thr Ile Asp Lys Phe Arg Arg Lys Asn Cys Pro Ser Cys Arg 
            580                 585                 590         


Leu Arg Lys Cys Tyr Glu Ala Gly Met Thr Leu Gly Ala Arg Lys Leu 
        595                 600                 605             


Lys Lys Leu Gly Asn Leu Lys Leu Gln Glu Glu Gly Glu Ala Ser Ser 
    610                 615                 620                 


Ala Thr Ser Pro Thr Glu Glu Pro Ala Gln Lys Leu Thr Val Ser His 
625                 630                 635                 640 


Ile Glu Gly Tyr Glu Cys Gln Pro Ile Phe Leu Asn Val Leu Glu Ala 
                645                 650                 655     


Ile Glu Pro Gly Val Val Cys Ala Gly His Asp Asn Asn Gln Pro Asp 
            660                 665                 670         


Ser Phe Ala Ala Leu Leu Ser Ser Leu Asn Glu Leu Gly Glu Arg Gln 
        675                 680                 685             


Leu Val His Val Val Lys Trp Ala Lys Ala Leu Pro Gly Phe Arg Asn 
    690                 695                 700                 


Leu His Val Asp Asp Gln Met Ala Val Ile Gln Tyr Ser Trp Met Gly 
705                 710                 715                 720 


Leu Met Val Phe Ala Met Gly Trp Arg Ser Phe Thr Asn Val Asn Ser 
                725                 730                 735     


Arg Met Leu Tyr Phe Ala Pro Asp Leu Val Phe Asn Glu Tyr Arg Met 
            740                 745                 750         


His Lys Ser Arg Met Tyr Ser Gln Cys Val Arg Met Arg His Leu Ser 
        755                 760                 765             


Gln Glu Phe Gly Trp Leu Gln Ile Thr Pro Gln Glu Phe Leu Cys Met 
    770                 775                 780                 


Lys Ala Leu Leu Leu Phe Ser Ile Ile Pro Val Asp Gly Leu Lys Asn 
785                 790                 795                 800 


Gln Lys Phe Phe Asp Glu Leu Arg Met Asn Tyr Ile Lys Glu Leu Asp 
                805                 810                 815     


Arg Ile Ile Ala Cys Lys Arg Lys Asn Pro Thr Ser Cys Ser Arg Arg 
            820                 825                 830         


Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser Val Gln Pro Ile Ala Arg 
        835                 840                 845             


Glu Leu His Gln Phe Thr Phe Asp Leu Leu Ile Lys Ser His Met Val 
    850                 855                 860                 


Ser Val Asp Phe Pro Glu Met Met Ala Glu Ile Ile Ser Val Gln Val 
865                 870                 875                 880 


Pro Lys Ile Leu Ser Gly Lys Val Lys Pro Ile Tyr Phe His Thr Gln 
                885                 890                 895     


<210>  17
<211>  709
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  17

His His Gln Gln Gln Gln Asp Ala Ala Thr Glu Gly Ser Ser Ser Gly 
1               5                   10                  15      


Arg Ala Arg Arg Pro Ser Gly Ala Ser Thr Ser Ser Lys Asp Ser Tyr 
            20                  25                  30          


Leu Gly Ser Thr Ser Val Ile Ser Asp Ser Ala Lys Glu Leu Cys Lys 
        35                  40                  45              


Ala Val Ser Val Ser Leu Gly Leu Gly Val Glu Ala Leu Glu His Leu 
    50                  55                  60                  


Ser Ser Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu Leu 
65                  70                  75                  80  


Gly Gly Pro Pro Val Val Arg Pro Thr Pro Cys Leu Pro Leu Val Glu 
                85                  90                  95      


Cys Lys Gly Ser Leu Leu Asp Asp Gly Pro Gly Lys Gly Thr Glu Glu 
            100                 105                 110         


Thr Ala Glu Tyr Thr Pro Phe Lys Gly Gly Tyr Asn Lys Gly Leu Glu 
        115                 120                 125             


Ala Glu Ser Leu Gly Cys Ser Gly Ser Gly Glu Ala Gly Ser Ser Gly 
    130                 135                 140                 


Thr Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Thr Leu 
145                 150                 155                 160 


Asp Glu Ala Ala Ala Tyr Gln Thr Arg Asp Tyr Tyr Asn Phe Pro Leu 
                165                 170                 175     


Ala Leu Ala Gly Gln Pro Pro Pro Pro His Pro Arg Arg Ile Lys Leu 
            180                 185                 190         


Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala Ala Ala Ala Ala Gln 
        195                 200                 205             


Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly Gly Gly Ala Ala Gly 
    210                 215                 220                 


Pro Gly Ser Gly Ser Pro Ser Thr Ala Ala Ser Ser Ser Trp His Thr 
225                 230                 235                 240 


Leu Phe Thr Thr Glu Glu Gly Gln Leu Tyr Gly Leu Cys Gly Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Pro Gly Glu Ala Gly Ala Val Ala Pro Tyr Gly Tyr 
            260                 265                 270         


Thr Arg Pro Pro Gln Gly Leu Thr Gly Gln Glu Gly Asp Phe Pro Ala 
        275                 280                 285             


Pro Glu Val Trp Tyr Pro Gly Gly Val Val Ser Arg Val Pro Tyr Pro 
    290                 295                 300                 


Asn Pro Ser Cys Val Lys Ser Glu Met Gly Pro Trp Met Glu Ser Tyr 
305                 310                 315                 320 


Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala Arg Asp His Val 
                325                 330                 335     


Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys Leu Ile Cys 
            340                 345                 350         


Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr Cys Gly Ser 
        355                 360                 365             


Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln Lys Tyr Leu 
    370                 375                 380                 


Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg Arg Lys Asn 
385                 390                 395                 400 


Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly Met Thr Leu 
                405                 410                 415     


Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu Gln Glu Glu 
            420                 425                 430         


Gly Glu Ser Ser Ser Ala Ser Ser Pro Thr Glu Asp Thr Thr Gln Lys 
        435                 440                 445             


Leu Thr Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro Ile Phe Leu 
    450                 455                 460                 


Asn Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala Gly His Asp 
465                 470                 475                 480 


Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser Leu Asn Glu 
                485                 490                 495     


Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala Lys Ala Leu 
            500                 505                 510         


Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala Val Ile Gln 
        515                 520                 525             


Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp Arg Ser Phe 
    530                 535                 540                 


Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp Leu Val Phe 
545                 550                 555                 560 


Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln Cys Val Arg 
                565                 570                 575     


Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile Thr Pro Gln 
            580                 585                 590         


Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile Ile Pro Val 
        595                 600                 605             


Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg Met Asn Tyr 
    610                 615                 620                 


Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys Asn Pro Thr 
625                 630                 635                 640 


Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser Val 
                645                 650                 655     


Gln Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp Leu Leu Ile 
            660                 665                 670         


Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met Ala Glu Ile 
        675                 680                 685             


Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val Lys Pro Ile 
    690                 695                 700                 


Tyr Phe His Thr Gln 
705                 


<210>  18
<211>  2760
<212>  DNA
<213>  Homo sapiens

<400>  18
atggaagtgc agttagggct gggaagggtc taccctcggc cgccgtccaa gacctaccga       60

ggagctttcc agaatctgtt ccagagcgtg cgcgaagtga tccagaaccc gggccccagg      120

cacccagagg ccgcgagcgc agcacctccc ggcgccagtt tgctgctgct gcagcagcag      180

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcaa      240

gagactagcc ccaggcagca gcagcagcag cagggtgagg atggttctcc ccaagcccat      300

cgtagaggcc ccacaggcta cctggtcctg gatgaggaac agcaaccttc acagccgcag      360

tcggccctgg agtgccaccc cgagagaggt tgcgtcccag agcctggagc cgccgtggcc      420

gccagcaagg ggctgccgca gcagctgcca gcacctccgg acgaggatga ctcagctgcc      480

ccatccacgt tgtccctgct gggccccact ttccccggct taagcagctg ctccgctgac      540

cttaaagaca tcctgagcga ggccagcacc atgcaactcc ttcagcaaca gcagcaggaa      600

gcagtatccg aaggcagcag cagcgggaga gcgagggagg cctcgggggc tcccacttcc      660

tccaaggaca attacttagg gggcacttcg accatttctg acaacgccaa ggagttgtgt      720

aaggcagtgt cggtgtccat gggcctgggt gtggaggcgt tggagcatct gagtccaggg      780

gaacagcttc ggggggattg catgtacgcc ccacttttgg gagttccacc cgctgtgcgt      840

cccactcctt gtgccccatt ggccgaatgc aaaggttctc tgctagacga cagcgcaggc      900

aagagcactg aagatactgc tgagtattcc cctttcaagg gaggttacac caaagggcta      960

gaaggcgaga gcctaggctg ctctggcagc gctgcagcag ggagctccgg gacacttgaa     1020

ctgccgtcta ccctgtctct ctacaagtcc ggagcactgg acgaggcagc tgcgtaccag     1080

agtcgcgact actacaactt tccactggct ctggccggac cgccgccccc tccgccgcct     1140

ccccatcccc acgctcgcat caagctggag aacccgctgg actacggcag cgcctgggcg     1200

gctgcggcgg cgcagtgccg ctatggggac ctggcgagcc tgcatggcgc gggtgcagcg     1260

ggacccggtt ctgggtcacc ctcagccgcc gcttcctcat cctggcacac tctcttcaca     1320

gccgaagaag gccagttgta tggaccgtgt ggtggtggtg ggggtggtgg cggcggcggc     1380

ggcggcggcg gcggcggcgg cggcggcggc ggcggcggcg aggcgggagc tgtagccccc     1440

tacggctaca ctcggccccc tcaggggctg gcgggccagg aaagcgactt caccgcacct     1500

gatgtgtggt accctggcgg catggtgagc agagtgccct atcccagtcc cacttgtgtc     1560

aaaagcgaaa tgggcccctg gatggatagc tactccggac cttacgggga catgcgtttg     1620

gagactgcca gggaccatgt tttgcccatt gactattact ttccacccca gaagacctgc     1680

ctgatctgtg gagatgaagc ttctgggtgt cactatggag ctctcacatg tggaagctgc     1740

aaggtcttct tcaaaagagc cgctgaaggg aaacagaagt acctgtgcgc cagcagaaat     1800

gattgcacta ttgataaatt ccgaaggaaa aattgtccat cttgtcgtct tcggaaatgt     1860

tatgaagcag ggatgactct gggagcccgg aagctgaaga aacttggtaa tctgaaacta     1920

caggaggaag gagaggcttc cagcaccacc agccccactg aggagacaac ccagaagctg     1980

acagtgtcac acattgaagg ctatgaatgt cagcccatct ttctgaatgt cctggaagcc     2040

attgagccag gtgtagtgtg tgctggacac gacaacaacc agcccgactc ctttgcagcc     2100

ttgctctcta gcctcaatga actgggagag agacagcttg tacacgtggt caagtgggcc     2160

aaggccttgc ctggcttccg caacttacac gtggacgacc agatggctgt cattcagtac     2220

tcctggatgg ggctcatggt gtttgccatg ggctggcgat ccttcaccaa tgtcaactcc     2280

aggatgctct acttcgcccc tgatctggtt ttcaatgagt accgcatgca caagtcccgg     2340

atgtacagcc agtgtgtccg aatgaggcac ctctctcaag agtttggatg gctccaaatc     2400

accccccagg aattcctgtg catgaaagca ctgctactct tcagcattat tccagtggat     2460

gggctgaaaa atcaaaaatt ctttgatgaa cttcgaatga actacatcaa ggaactcgat     2520

cgtatcattg catgcaaaag aaaaaatccc acatcctgct caagacgctt ctaccagctc     2580

accaagctcc tggactccgt gcagcctatt gcgagagagc tgcatcagtt cacttttgac     2640

ctgctaatca agtcacacat ggtgagcgtg gactttccgg aaatgatggc agagatcatc     2700

tctgtgcaag tgcccaagat cctttctggg aaagtcaagc ccatctattt ccacacccag     2760


<210>  19
<211>  2760
<212>  DNA
<213>  Homo sapiens

<400>  19
atggaagtgc agttagggct gggaagggtc taccctcggc cgccgtccaa gacctaccga       60

ggagctttcc agaatctgtt ccagagcgtg cgcgaagtga tccagaaccc gggccccagg      120

cacccagagg ccgcgagcgc agcacctccc ggcgccagtt tgctgctgct gcagcagcag      180

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcaa      240

gagactagcc ccaggcagca gcagcagcag cagggtgagg atggttctcc ccaagcccat      300

cgtagaggcc ccacaggcta cctggtcctg gatgaggaac agcaaccttc acagccgcag      360

tcggccctgg agtgccaccc cgagagaggt tgcgtcccag agcctggagc cgccgtggcc      420

gccagcaagg ggctgccgca gcagctgcca gcacctccgg acgaggatga ctcagctgcc      480

ccatccacgt tgtccctgct gggccccact ttccccggct taagcagctg ctccgctgac      540

cttaaagaca tcctgagcga ggccagcacc atgcaactcc ttcagcaaca gcagcaggaa      600

gcagtatccg aaggcagcag cagcgggaga gcgagggagg cctcgggggc tcccacttcc      660

tccaaggaca attacttagg gggcacttcg accatttctg acaacgccaa ggagttgtgt      720

aaggcagtgt cggtgtccat gggcctgggt gtggaggcgt tggagcatct gagtccaggg      780

gaacagcttc ggggggattg catgtacgcc ccacttttgg gagttccacc cgctgtgcgt      840

cccactcctt gtgccccatt ggccgaatgc aaaggttctc tgctagacga cagcgcaggc      900

aagagcactg aagatactgc tgagtattcc cctttcaagg gaggttacac caaagggcta      960

gaaggcgaga gcctaggctg ctctggcagc gctgcagcag ggagctccgg gacacttgaa     1020

ctgccgtcta ccctgtctct ctacaagtcc ggagcactgg acgaggcagc tgcgtaccag     1080

agtcgcgact actacaactt tccactggct ctggccggac cgccgccccc tccgccgcct     1140

ccccatcccc acgctcgcat caagctggag aacccgctgg actacggcag cgcctgggcg     1200

gctgcggcgg cgcagtgccg ctatggggac ctggcgagcc tgcatggcgc gggtgcagcg     1260

ggacccggtt ctgggtcacc ctcagccgcc gcttcctcat cctggcacac tctcttcaca     1320

gccgaagaag gccagttgta tggaccgtgt ggtggtggtg ggggtggtgg cggcggcggc     1380

ggcggcggcg gcggcggcgg cggcggcggc ggcggcggcg aggcgggagc tgtagccccc     1440

tacggctaca ctcggccccc tcaggggctg gcgggccagg aaagcgactt caccgcacct     1500

gatgtgtggt accctggcgg catggtgagc agagtgccct atcccagtcc cacttgtgtc     1560

aaaagcgaaa tgggcccctg gatggatagc tactccggac cttacgggga catgcgtttg     1620

gagactgcca gggaccatgt tttgcccatt gactattact ttccacccca gaagacctgc     1680

ctgatctgtg gagatgaagc ttctgggtgt cactatggag ctctcacatg tggaagctgc     1740

aaggtcttct tcaaaagagc cgctgaaggg aaacagaagt acctgtgcgc cagcagaaat     1800

gattgcacta ttgataaatt ccgaaggaaa aattgtccat cttgtcgtct tcggaaatgt     1860

tatgaagcag ggatgactct gggagcccgg aagctgaaga aacttggtaa tctgaaacta     1920

caggaggaag gagaggcttc cagcaccacc agccccactg aggagacaac ccagaagctg     1980

acagtgtcac acattgaagg ctatgaatgt cagcccatct ttctgaatgt cctggaagcc     2040

attgagccag gtgtagtgtg tgctggacac gacaacaacc agcccgactc ctttgcagcc     2100

ttgctctcta gcctcaatga actgggagag agacagcttg tacacgtggt caagtgggcc     2160

aaggccttgc ctggcttccg caacttacac gtggacgacc agatggctgt cattcagtac     2220

tcctggatgg ggctcatggt gtttgccatg ggctggcgat ccttcaccaa tgtcaactcc     2280

aggatgctct acttcgcccc tgatctggtt ttcaatgagt accgcatgca caagtcccgg     2340

atgtacagcc agtgtgtccg aatgaggcac ctctctcaag agtttggatg gctccaaatc     2400

accccccagg aattcctgtg catgaaagca ctgctactct tcagcattat tccagtggat     2460

gggctgaaaa atcaaaaatt ctttgatgaa cttcgaatga actacatcaa ggaactcgat     2520

cgtatcattg catgcaaaag aaaaaatccc acatcctgct caagacgctt ctaccagctc     2580

accaagctcc tggactccgt gcagcctatt gcgagagagc tgcatcagct cacttttgac     2640

ctgctaatca agtcacacat ggtgagcgtg gactttccgg aaatgatggc agagatcatc     2700

tctgtgcaag tgcccaagat cctttctggg aaagtcaagc ccatctattt ccacacccag     2760


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  20
agagactcag aggcgaccat                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  21
atcagcaaac acagcagctc                                                   20


<210>  22
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  22
agagctgttg gatgaggacc agaa                                              24


<210>  23
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  23
aggctccaaa ggcacttgac tact                                              24


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  24
gaccaagcgg gttgttattg a                                                 21


<210>  25
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  25
tgccttgtcg gtcatatttt tca                                               23


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  26
cggagaacca aacggaaagg                                                   20


<210>  27
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  27
cttcgcccac agtgaatgc                                                    19


<210>  28
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  28
acagcagccg gtttattgtg cttc                                              24


<210>  29
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  29
tggcattcag tctcacacca ctgt                                              24


<210>  30
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  30
accactcacc atcatctcaa ggca                                              24


<210>  31
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  31
tgctcttctt tgccagatcc tcgt                                              24


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  32
gccttaccct tgcagcttac                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  33
gagcatgctg tccactctgt                                                   20


<210>  34
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  34
cttgcgcatt cccaagtcag atgt                                              24


<210>  35
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  35
tttcctctcc ttctcgtgct gctt                                              24


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  36
gagcctgcta cagatggtca                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  37
tgtctaccag caggacgaag                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  38
cctcctgaag aatcgattcc                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  39
gaggtccaca cactgaagtt                                                   20


<210>  40
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  40
tttctgggct ggccaaacat aagc                                              24


<210>  41
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  41
acacaaggta atgtgtgggt ccga                                              24


<210>  42
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  42
cggcaggtgt ttgtgtgtgg aaat                                              24


<210>  43
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  43
agaagacaca cagcacagca gaca                                              24


<210>  44
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  44
tagtgaaacc agtgtgtctg ccca                                              24


<210>  45
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  45
agcgttcagc acttctgagg tctt                                              24


<210>  46
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  46
cgctctggtt catctgctct g                                                 21


<210>  47
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  47
tcatcaaagg tgctctcgtc tg                                                22


<210>  48
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  48
tggagaggaa gttcagccat caga                                              24


<210>  49
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  49
aggagagctg ctttcgctta gtct                                              24


<210>  50
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  50
acctgctcag cctttgtctc tgat                                              24


<210>  51
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  51
agatccaggc ttgcttactg tcct                                              24


<210>  52
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  52
attctgggtt gggagtgcaa ggaa                                              24


<210>  53
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  53
aggagacatg cccaggatga aaca                                              24


<210>  54
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  54
actaggcagg acattgacat ccca                                              24


<210>  55
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  55
acagtaaacc tctccacaca tggc                                              24


<210>  56
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  56
tatgacaccc agggctttcg ttca                                              24


<210>  57
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  57
taacgttccc tgcgcgttta caga                                              24


<210>  58
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  58
tcccaaatcc tgacccca                                                     18


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  59
accacacagc ccctaggaga                                                   20


<210>  60
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  60
acagggtggc ccaaatagaa c                                                 21


<210>  61
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  61
cctgtcttgg acaagcggag a                                                 21


<210>  62
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  62
gggtcatttc caccacctca aaca                                              24


<210>  63
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  63
ggagaaaggc cttacagtag tctc                                              24


