                         SEQUENCE LISTING

<110>  GENOCEA BIOSCIENCES, INC.
       CHILDREN'S MEDICAL CENTER CORPORATION
 
<120>  FUSED ANTIGEN VACCINES AND COMPOSITIONS AGAINST STREPTOCOCCUS 
       PNEUMONIAE

<130>  2007781-0139

<150>  61/676,276
<151>  2012-07-26

<160>  168   

<170>  PatentIn version 3.5

<210>  1
<211>  255
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  1

Met Cys Ser Gly Gly Ala Lys Lys Glu Gly Glu Ala Ala Ser Lys Lys 
1               5                   10                  15      


Glu Ile Ile Val Ala Thr Asn Gly Ser Pro Lys Pro Phe Ile Tyr Glu 
            20                  25                  30          


Glu Asn Gly Glu Leu Thr Gly Tyr Glu Ile Glu Val Val Arg Ala Ile 
        35                  40                  45              


Phe Lys Asp Ser Asp Lys Tyr Asp Val Lys Phe Glu Lys Thr Glu Trp 
    50                  55                  60                  


Ser Gly Val Phe Ala Gly Leu Asp Ala Asp Arg Tyr Asn Met Ala Val 
65                  70                  75                  80  


Asn Asn Leu Ser Tyr Thr Lys Glu Arg Ala Glu Lys Tyr Leu Tyr Ala 
                85                  90                  95      


Ala Pro Ile Ala Gln Asn Pro Asn Val Leu Val Val Lys Lys Asp Asp 
            100                 105                 110         


Ser Ser Ile Lys Ser Leu Asp Asp Ile Gly Gly Lys Ser Thr Glu Val 
        115                 120                 125             


Val Gln Ala Thr Thr Ser Ala Lys Gln Leu Glu Ala Tyr Asn Ala Glu 
    130                 135                 140                 


His Thr Asp Asn Pro Thr Ile Leu Asn Tyr Thr Lys Ala Asp Phe Gln 
145                 150                 155                 160 


Gln Ile Met Val Arg Leu Ser Asp Gly Gln Phe Asp Tyr Lys Ile Phe 
                165                 170                 175     


Asp Lys Ile Gly Val Glu Thr Val Ile Lys Asn Gln Gly Leu Asp Asn 
            180                 185                 190         


Leu Lys Val Ile Glu Leu Pro Ser Asp Gln Gln Pro Tyr Val Tyr Pro 
        195                 200                 205             


Leu Leu Ala Gln Gly Gln Asp Glu Leu Lys Ser Phe Val Asp Lys Arg 
    210                 215                 220                 


Ile Lys Glu Leu Tyr Lys Asp Gly Thr Leu Glu Lys Leu Ser Lys Gln 
225                 230                 235                 240 


Phe Phe Gly Asp Thr Tyr Leu Pro Ala Glu Ala Asp Ile Lys Glu 
                245                 250                 255 


<210>  2
<211>  277
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  2

Met Lys Lys Ile Val Lys Tyr Ser Ser Leu Ala Ala Leu Ala Leu Val 
1               5                   10                  15      


Ala Ala Gly Val Leu Ala Ala Cys Ser Gly Gly Ala Lys Lys Glu Gly 
            20                  25                  30          


Glu Ala Ala Ser Lys Lys Glu Ile Ile Val Ala Thr Asn Gly Ser Pro 
        35                  40                  45              


Lys Pro Phe Ile Tyr Glu Glu Asn Gly Glu Leu Thr Gly Tyr Glu Ile 
    50                  55                  60                  


Glu Val Val Arg Ala Ile Phe Lys Asp Ser Asp Lys Tyr Asp Val Lys 
65                  70                  75                  80  


Phe Glu Lys Thr Glu Trp Ser Gly Val Phe Ala Gly Leu Asp Ala Asp 
                85                  90                  95      


Arg Tyr Asn Met Ala Val Asn Asn Leu Ser Tyr Thr Lys Glu Arg Ala 
            100                 105                 110         


Glu Lys Tyr Leu Tyr Ala Ala Pro Ile Ala Gln Asn Pro Asn Val Leu 
        115                 120                 125             


Val Val Lys Lys Asp Asp Ser Ser Ile Lys Ser Leu Asp Asp Ile Gly 
    130                 135                 140                 


Gly Lys Ser Thr Glu Val Val Gln Ala Thr Thr Ser Ala Lys Gln Leu 
145                 150                 155                 160 


Glu Ala Tyr Asn Ala Glu His Thr Asp Asn Pro Thr Ile Leu Asn Tyr 
                165                 170                 175     


Thr Lys Ala Asp Phe Gln Gln Ile Met Val Arg Leu Ser Asp Gly Gln 
            180                 185                 190         


Phe Asp Tyr Lys Ile Phe Asp Lys Ile Gly Val Glu Thr Val Ile Lys 
        195                 200                 205             


Asn Gln Gly Leu Asp Asn Leu Lys Val Ile Glu Leu Pro Ser Asp Gln 
    210                 215                 220                 


Gln Pro Tyr Val Tyr Pro Leu Leu Ala Gln Gly Gln Asp Glu Leu Lys 
225                 230                 235                 240 


Ser Phe Val Asp Lys Arg Ile Lys Glu Leu Tyr Lys Asp Gly Thr Leu 
                245                 250                 255     


Glu Lys Leu Ser Lys Gln Phe Phe Gly Asp Thr Tyr Leu Pro Ala Glu 
            260                 265                 270         


Ala Asp Ile Lys Glu 
        275         


<210>  3
<211>  255
<212>  PRT
<213>  Streptococcus pneumoniae


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Glu or Gln

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gly or Ser

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Lys or Arg

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Ile or Asn

<220>
<221>  MOD_RES
<222>  (56)..(56)
<223>  Asp or Asn

<220>
<221>  MOD_RES
<222>  (58)..(58)
<223>  Lys or any amino acid

<220>
<221>  MOD_RES
<222>  (83)..(83)
<223>  Leu or Ile

<220>
<221>  MOD_RES
<222>  (111)..(111)
<223>  Asp or Glu

<220>
<221>  MOD_RES
<222>  (159)..(159)
<223>  Leu or Phe

<220>
<221>  MOD_RES
<222>  (192)..(192)
<223>  Asn or Tyr

<220>
<221>  MOD_RES
<222>  (199)..(199)
<223>  Pro or Ser

<220>
<221>  MOD_RES
<222>  (255)..(255)
<223>  May or may not be present

<400>  3

Met Cys Ser Gly Gly Ala Lys Lys Glu Gly Xaa Ala Ala Ser Lys Lys 
1               5                   10                  15      


Glu Ile Ile Val Ala Thr Asn Xaa Ser Pro Xaa Pro Phe Xaa Tyr Glu 
            20                  25                  30          


Glu Asn Gly Glu Leu Thr Gly Tyr Glu Ile Glu Val Val Arg Ala Ile 
        35                  40                  45              


Phe Lys Asp Ser Asp Lys Tyr Xaa Val Xaa Phe Glu Lys Thr Glu Trp 
    50                  55                  60                  


Ser Gly Val Phe Ala Gly Leu Asp Ala Asp Arg Tyr Asn Met Ala Val 
65                  70                  75                  80  


Asn Asn Xaa Ser Tyr Thr Lys Glu Arg Ala Glu Lys Tyr Leu Tyr Ala 
                85                  90                  95      


Ala Pro Ile Ala Gln Asn Pro Asn Val Leu Val Val Lys Lys Xaa Asp 
            100                 105                 110         


Ser Ser Ile Lys Ser Leu Asp Asp Ile Gly Gly Lys Ser Thr Glu Val 
        115                 120                 125             


Val Gln Ala Thr Thr Ser Ala Lys Gln Leu Glu Ala Tyr Asn Ala Glu 
    130                 135                 140                 


His Thr Asp Asn Pro Thr Ile Leu Asn Tyr Thr Lys Ala Asp Xaa Gln 
145                 150                 155                 160 


Gln Ile Met Val Arg Leu Ser Asp Gly Gln Phe Asp Tyr Lys Ile Phe 
                165                 170                 175     


Asp Lys Ile Gly Val Glu Thr Val Ile Lys Asn Gln Gly Leu Asp Xaa 
            180                 185                 190         


Leu Lys Val Ile Glu Leu Xaa Ser Asp Gln Gln Pro Tyr Val Tyr Pro 
        195                 200                 205             


Leu Leu Ala Gln Gly Gln Asp Glu Leu Lys Ser Phe Val Asp Lys Arg 
    210                 215                 220                 


Ile Lys Glu Leu Tyr Lys Asp Gly Thr Leu Glu Lys Leu Ser Lys Gln 
225                 230                 235                 240 


Phe Phe Gly Asp Thr Tyr Leu Pro Ala Glu Ala Asp Ile Lys Glu 
                245                 250                 255 


<210>  4
<211>  277
<212>  PRT
<213>  Streptococcus pneumoniae


<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Ala or Gly

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Val or Leu

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  Glu or Gln

<220>
<221>  MOD_RES
<222>  (46)..(46)
<223>  Gly or Ser

<220>
<221>  MOD_RES
<222>  (49)..(49)
<223>  Lys or Arg

<220>
<221>  MOD_RES
<222>  (52)..(52)
<223>  Ile or Asn

<220>
<221>  MOD_RES
<222>  (78)..(78)
<223>  Asp or Asn

<220>
<221>  MOD_RES
<222>  (80)..(80)
<223>  Lys or any amino acid

<220>
<221>  MOD_RES
<222>  (105)..(105)
<223>  Leu or Ile

<220>
<221>  MOD_RES
<222>  (133)..(133)
<223>  Asp or Glu

<220>
<221>  MOD_RES
<222>  (181)..(181)
<223>  Leu or Phe

<220>
<221>  MOD_RES
<222>  (214)..(214)
<223>  Asn or Tyr

<220>
<221>  MOD_RES
<222>  (221)..(221)
<223>  Pro or Ser

<220>
<221>  MOD_RES
<222>  (277)..(277)
<223>  May or may not be present

<400>  4

Met Lys Lys Ile Val Lys Tyr Ser Ser Leu Ala Ala Leu Xaa Leu Val 
1               5                   10                  15      


Ala Ala Gly Xaa Leu Ala Ala Cys Ser Gly Gly Ala Lys Lys Glu Gly 
            20                  25                  30          


Xaa Ala Ala Ser Lys Lys Glu Ile Ile Val Ala Thr Asn Xaa Ser Pro 
        35                  40                  45              


Xaa Pro Phe Xaa Tyr Glu Glu Asn Gly Glu Leu Thr Gly Tyr Glu Ile 
    50                  55                  60                  


Glu Val Val Arg Ala Ile Phe Lys Asp Ser Asp Lys Tyr Xaa Val Xaa 
65                  70                  75                  80  


Phe Glu Lys Thr Glu Trp Ser Gly Val Phe Ala Gly Leu Asp Ala Asp 
                85                  90                  95      


Arg Tyr Asn Met Ala Val Asn Asn Xaa Ser Tyr Thr Lys Glu Arg Ala 
            100                 105                 110         


Glu Lys Tyr Leu Tyr Ala Ala Pro Ile Ala Gln Asn Pro Asn Val Leu 
        115                 120                 125             


Val Val Lys Lys Xaa Asp Ser Ser Ile Lys Ser Leu Asp Asp Ile Gly 
    130                 135                 140                 


Gly Lys Ser Thr Glu Val Val Gln Ala Thr Thr Ser Ala Lys Gln Leu 
145                 150                 155                 160 


Glu Ala Tyr Asn Ala Glu His Thr Asp Asn Pro Thr Ile Leu Asn Tyr 
                165                 170                 175     


Thr Lys Ala Asp Xaa Gln Gln Ile Met Val Arg Leu Ser Asp Gly Gln 
            180                 185                 190         


Phe Asp Tyr Lys Ile Phe Asp Lys Ile Gly Val Glu Thr Val Ile Lys 
        195                 200                 205             


Asn Gln Gly Leu Asp Xaa Leu Lys Val Ile Glu Leu Xaa Ser Asp Gln 
    210                 215                 220                 


Gln Pro Tyr Val Tyr Pro Leu Leu Ala Gln Gly Gln Asp Glu Leu Lys 
225                 230                 235                 240 


Ser Phe Val Asp Lys Arg Ile Lys Glu Leu Tyr Lys Asp Gly Thr Leu 
                245                 250                 255     


Glu Lys Leu Ser Lys Gln Phe Phe Gly Asp Thr Tyr Leu Pro Ala Glu 
            260                 265                 270         


Ala Asp Ile Lys Glu 
        275         


<210>  5
<211>  400
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  5

Met Cys Gly Ser Lys Thr Ala Asp Lys Pro Ala Asp Ser Gly Ser Ser 
1               5                   10                  15      


Glu Val Lys Glu Leu Thr Val Tyr Val Asp Glu Gly Tyr Lys Ser Tyr 
            20                  25                  30          


Ile Glu Glu Val Ala Lys Ala Tyr Glu Lys Glu Ala Gly Val Lys Val 
        35                  40                  45              


Thr Leu Lys Thr Gly Asp Ala Leu Gly Gly Leu Asp Lys Leu Ser Leu 
    50                  55                  60                  


Asp Asn Gln Ser Gly Asn Val Pro Asp Val Met Met Ala Pro Tyr Asp 
65                  70                  75                  80  


Arg Val Gly Ser Leu Gly Ser Asp Gly Gln Leu Ser Glu Val Lys Leu 
                85                  90                  95      


Ser Asp Gly Ala Lys Thr Asp Asp Thr Thr Lys Ser Leu Val Thr Ala 
            100                 105                 110         


Ala Asn Gly Lys Val Tyr Gly Ala Pro Ala Val Ile Glu Ser Leu Val 
        115                 120                 125             


Met Tyr Tyr Asn Lys Asp Leu Val Lys Asp Ala Pro Lys Thr Phe Ala 
    130                 135                 140                 


Asp Leu Glu Asn Leu Ala Lys Asp Ser Lys Tyr Ala Phe Ala Gly Glu 
145                 150                 155                 160 


Asp Gly Lys Thr Thr Ala Phe Leu Ala Asp Trp Thr Asn Phe Tyr Tyr 
                165                 170                 175     


Thr Tyr Gly Leu Leu Ala Gly Asn Gly Ala Tyr Val Phe Gly Gln Asn 
            180                 185                 190         


Gly Lys Asp Ala Lys Asp Ile Gly Leu Ala Asn Asp Gly Ser Ile Val 
        195                 200                 205             


Gly Ile Asn Tyr Ala Lys Ser Trp Tyr Glu Lys Trp Pro Lys Gly Met 
    210                 215                 220                 


Gln Asp Thr Glu Gly Ala Gly Asn Leu Ile Gln Thr Gln Phe Gln Glu 
225                 230                 235                 240 


Gly Lys Thr Ala Ala Ile Ile Asp Gly Pro Trp Lys Ala Gln Ala Phe 
                245                 250                 255     


Lys Asp Ala Lys Val Asn Tyr Gly Val Ala Thr Ile Pro Thr Leu Pro 
            260                 265                 270         


Asn Gly Lys Glu Tyr Ala Ala Phe Gly Gly Gly Lys Ala Trp Val Ile 
        275                 280                 285             


Pro Gln Ala Val Lys Asn Leu Glu Ala Ser Gln Lys Phe Val Asp Phe 
    290                 295                 300                 


Leu Val Ala Thr Glu Gln Gln Lys Val Leu Tyr Asp Lys Thr Asn Glu 
305                 310                 315                 320 


Ile Pro Ala Asn Thr Glu Ala Arg Ser Tyr Ala Glu Gly Lys Asn Asp 
                325                 330                 335     


Glu Leu Thr Thr Ala Val Ile Lys Gln Phe Lys Asn Thr Gln Pro Leu 
            340                 345                 350         


Pro Asn Ile Ser Gln Met Ser Ala Val Trp Asp Pro Ala Lys Asn Met 
        355                 360                 365             


Leu Phe Asp Ala Val Ser Gly Gln Lys Asp Ala Lys Thr Ala Ala Asn 
    370                 375                 380                 


Asp Ala Val Thr Leu Ile Lys Glu Thr Ile Lys Gln Lys Phe Gly Glu 
385                 390                 395                 400 


<210>  6
<211>  423
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  6

Met Ser Ser Lys Phe Met Lys Ser Ala Ala Val Leu Gly Thr Ala Thr 
1               5                   10                  15      


Leu Ala Ser Leu Leu Leu Val Ala Cys Gly Ser Lys Thr Ala Asp Lys 
            20                  25                  30          


Pro Ala Asp Ser Gly Ser Ser Glu Val Lys Glu Leu Thr Val Tyr Val 
        35                  40                  45              


Asp Glu Gly Tyr Lys Ser Tyr Ile Glu Glu Val Ala Lys Ala Tyr Glu 
    50                  55                  60                  


Lys Glu Ala Gly Val Lys Val Thr Leu Lys Thr Gly Asp Ala Leu Gly 
65                  70                  75                  80  


Gly Leu Asp Lys Leu Ser Leu Asp Asn Gln Ser Gly Asn Val Pro Asp 
                85                  90                  95      


Val Met Met Ala Pro Tyr Asp Arg Val Gly Ser Leu Gly Ser Asp Gly 
            100                 105                 110         


Gln Leu Ser Glu Val Lys Leu Ser Asp Gly Ala Lys Thr Asp Asp Thr 
        115                 120                 125             


Thr Lys Ser Leu Val Thr Ala Ala Asn Gly Lys Val Tyr Gly Ala Pro 
    130                 135                 140                 


Ala Val Ile Glu Ser Leu Val Met Tyr Tyr Asn Lys Asp Leu Val Lys 
145                 150                 155                 160 


Asp Ala Pro Lys Thr Phe Ala Asp Leu Glu Asn Leu Ala Lys Asp Ser 
                165                 170                 175     


Lys Tyr Ala Phe Ala Gly Glu Asp Gly Lys Thr Thr Ala Phe Leu Ala 
            180                 185                 190         


Asp Trp Thr Asn Phe Tyr Tyr Thr Tyr Gly Leu Leu Ala Gly Asn Gly 
        195                 200                 205             


Ala Tyr Val Phe Gly Gln Asn Gly Lys Asp Ala Lys Asp Ile Gly Leu 
    210                 215                 220                 


Ala Asn Asp Gly Ser Ile Val Gly Ile Asn Tyr Ala Lys Ser Trp Tyr 
225                 230                 235                 240 


Glu Lys Trp Pro Lys Gly Met Gln Asp Thr Glu Gly Ala Gly Asn Leu 
                245                 250                 255     


Ile Gln Thr Gln Phe Gln Glu Gly Lys Thr Ala Ala Ile Ile Asp Gly 
            260                 265                 270         


Pro Trp Lys Ala Gln Ala Phe Lys Asp Ala Lys Val Asn Tyr Gly Val 
        275                 280                 285             


Ala Thr Ile Pro Thr Leu Pro Asn Gly Lys Glu Tyr Ala Ala Phe Gly 
    290                 295                 300                 


Gly Gly Lys Ala Trp Val Ile Pro Gln Ala Val Lys Asn Leu Glu Ala 
305                 310                 315                 320 


Ser Gln Lys Phe Val Asp Phe Leu Val Ala Thr Glu Gln Gln Lys Val 
                325                 330                 335     


Leu Tyr Asp Lys Thr Asn Glu Ile Pro Ala Asn Thr Glu Ala Arg Ser 
            340                 345                 350         


Tyr Ala Glu Gly Lys Asn Asp Glu Leu Thr Thr Ala Val Ile Lys Gln 
        355                 360                 365             


Phe Lys Asn Thr Gln Pro Leu Pro Asn Ile Ser Gln Met Ser Ala Val 
    370                 375                 380                 


Trp Asp Pro Ala Lys Asn Met Leu Phe Asp Ala Val Ser Gly Gln Lys 
385                 390                 395                 400 


Asp Ala Lys Thr Ala Ala Asn Asp Ala Val Thr Leu Ile Lys Glu Thr 
                405                 410                 415     


Ile Lys Gln Lys Phe Gly Glu 
            420             


<210>  7
<211>  400
<212>  PRT
<213>  Streptococcus pneumoniae


<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Val or Ala

<220>
<221>  MOD_RES
<222>  (48)..(48)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (74)..(74)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (83)..(83)
<223>  Gly or any amino acid

<220>
<221>  MOD_RES
<222>  (100)..(100)
<223>  Ala or Thr

<220>
<221>  MOD_RES
<222>  (177)..(177)
<223>  Thr or Ala

<220>
<221>  MOD_RES
<222>  (186)..(186)
<223>  Ala or Gly

<220>
<221>  MOD_RES
<222>  (196)..(196)
<223>  Ala or Pro

<220>
<221>  MOD_RES
<222>  (208)..(208)
<223>  Val or Ala

<220>
<221>  MOD_RES
<222>  (214)..(214)
<223>  Lys or any amino acid

<220>
<221>  MOD_RES
<222>  (237)..(237)
<223>  Gln or His

<220>
<221>  MOD_RES
<222>  (298)..(298)
<223>  Ser or Ala

<220>
<221>  MOD_RES
<222>  (307)..(307)
<223>  Ala or Ser

<220>
<221>  MOD_RES
<222>  (313)..(313)
<223>  Val or Ala

<220>
<221>  MOD_RES
<222>  (348)..(348)
<223>  Asn or Ser

<400>  7

Met Cys Gly Ser Lys Thr Ala Asp Lys Pro Ala Asp Ser Gly Ser Ser 
1               5                   10                  15      


Glu Xaa Lys Glu Leu Thr Val Tyr Val Asp Glu Gly Tyr Lys Ser Tyr 
            20                  25                  30          


Ile Glu Glu Val Ala Lys Ala Tyr Glu Lys Glu Ala Gly Val Lys Xaa 
        35                  40                  45              


Thr Leu Lys Thr Gly Asp Ala Leu Gly Gly Leu Asp Lys Leu Ser Leu 
    50                  55                  60                  


Asp Asn Gln Ser Gly Asn Val Pro Asp Xaa Met Met Ala Pro Tyr Asp 
65                  70                  75                  80  


Arg Val Xaa Ser Leu Gly Ser Asp Gly Gln Leu Ser Glu Val Lys Leu 
                85                  90                  95      


Ser Asp Gly Xaa Lys Thr Asp Asp Thr Thr Lys Ser Leu Val Thr Ala 
            100                 105                 110         


Ala Asn Gly Lys Val Tyr Gly Ala Pro Ala Val Ile Glu Ser Leu Val 
        115                 120                 125             


Met Tyr Tyr Asn Lys Asp Leu Val Lys Asp Ala Pro Lys Thr Phe Ala 
    130                 135                 140                 


Asp Leu Glu Asn Leu Ala Lys Asp Ser Lys Tyr Ala Phe Ala Gly Glu 
145                 150                 155                 160 


Asp Gly Lys Thr Thr Ala Phe Leu Ala Asp Trp Thr Asn Phe Tyr Tyr 
                165                 170                 175     


Xaa Tyr Gly Leu Leu Ala Gly Asn Gly Xaa Tyr Val Phe Gly Gln Asn 
            180                 185                 190         


Gly Lys Asp Xaa Lys Asp Ile Gly Leu Ala Asn Asp Gly Ser Ile Xaa 
        195                 200                 205             


Gly Ile Asn Tyr Ala Xaa Ser Trp Tyr Glu Lys Trp Pro Lys Gly Met 
    210                 215                 220                 


Gln Asp Thr Glu Gly Ala Gly Asn Leu Ile Gln Thr Xaa Phe Gln Glu 
225                 230                 235                 240 


Gly Lys Thr Ala Ala Ile Ile Asp Gly Pro Trp Lys Ala Gln Ala Phe 
                245                 250                 255     


Lys Asp Ala Lys Val Asn Tyr Gly Val Ala Thr Ile Pro Thr Leu Pro 
            260                 265                 270         


Asn Gly Lys Glu Tyr Ala Ala Phe Gly Gly Gly Lys Ala Trp Val Ile 
        275                 280                 285             


Pro Gln Ala Val Lys Asn Leu Glu Ala Xaa Gln Lys Phe Val Asp Phe 
    290                 295                 300                 


Leu Val Xaa Thr Glu Gln Gln Lys Xaa Leu Tyr Asp Lys Thr Asn Glu 
305                 310                 315                 320 


Ile Pro Ala Asn Thr Glu Ala Arg Ser Tyr Ala Glu Gly Lys Asn Asp 
                325                 330                 335     


Glu Leu Thr Thr Ala Val Ile Lys Gln Phe Lys Xaa Thr Gln Pro Leu 
            340                 345                 350         


Pro Asn Ile Ser Gln Met Ser Ala Val Trp Asp Pro Ala Lys Asn Met 
        355                 360                 365             


Leu Phe Asp Ala Val Ser Gly Gln Lys Asp Ala Lys Thr Ala Ala Asn 
    370                 375                 380                 


Asp Ala Val Thr Leu Ile Lys Glu Thr Ile Lys Gln Lys Phe Gly Glu 
385                 390                 395                 400 


<210>  8
<211>  423
<212>  PRT
<213>  Streptococcus pneumoniae


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Met or Thr

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Ala or Thr

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Ala or Val

<220>
<221>  MOD_RES
<222>  (41)..(41)
<223>  Val or Ala

<220>
<221>  MOD_RES
<222>  (71)..(71)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (97)..(97)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (106)..(106)
<223>  Gly or any amino acid

<220>
<221>  MOD_RES
<222>  (123)..(123)
<223>  Ala or Thr

<220>
<221>  MOD_RES
<222>  (200)..(200)
<223>  Thr or Ala

<220>
<221>  MOD_RES
<222>  (209)..(209)
<223>  Ala or Gly

<220>
<221>  MOD_RES
<222>  (219)..(219)
<223>  Ala or Pro

<220>
<221>  MOD_RES
<222>  (231)..(231)
<223>  Val or Ala

<220>
<221>  MOD_RES
<222>  (237)..(237)
<223>  Lys or any amino acid

<220>
<221>  MOD_RES
<222>  (260)..(260)
<223>  Gln or His

<220>
<221>  MOD_RES
<222>  (321)..(321)
<223>  Ser or Ala

<220>
<221>  MOD_RES
<222>  (330)..(330)
<223>  Ala or Ser

<220>
<221>  MOD_RES
<222>  (336)..(336)
<223>  Val or Ala

<220>
<221>  MOD_RES
<222>  (371)..(371)
<223>  Asn or Ser

<400>  8

Met Ser Ser Lys Phe Xaa Lys Ser Xaa Ala Val Leu Gly Thr Xaa Thr 
1               5                   10                  15      


Leu Ala Ser Leu Leu Leu Val Ala Cys Gly Ser Lys Thr Ala Asp Lys 
            20                  25                  30          


Pro Ala Asp Ser Gly Ser Ser Glu Xaa Lys Glu Leu Thr Val Tyr Val 
        35                  40                  45              


Asp Glu Gly Tyr Lys Ser Tyr Ile Glu Glu Val Ala Lys Ala Tyr Glu 
    50                  55                  60                  


Lys Glu Ala Gly Val Lys Xaa Thr Leu Lys Thr Gly Asp Ala Leu Gly 
65                  70                  75                  80  


Gly Leu Asp Lys Leu Ser Leu Asp Asn Gln Ser Gly Asn Val Pro Asp 
                85                  90                  95      


Xaa Met Met Ala Pro Tyr Asp Arg Val Xaa Ser Leu Gly Ser Asp Gly 
            100                 105                 110         


Gln Leu Ser Glu Val Lys Leu Ser Asp Gly Xaa Lys Thr Asp Asp Thr 
        115                 120                 125             


Thr Lys Ser Leu Val Thr Ala Ala Asn Gly Lys Val Tyr Gly Ala Pro 
    130                 135                 140                 


Ala Val Ile Glu Ser Leu Val Met Tyr Tyr Asn Lys Asp Leu Val Lys 
145                 150                 155                 160 


Asp Ala Pro Lys Thr Phe Ala Asp Leu Glu Asn Leu Ala Lys Asp Ser 
                165                 170                 175     


Lys Tyr Ala Phe Ala Gly Glu Asp Gly Lys Thr Thr Ala Phe Leu Ala 
            180                 185                 190         


Asp Trp Thr Asn Phe Tyr Tyr Xaa Tyr Gly Leu Leu Ala Gly Asn Gly 
        195                 200                 205             


Xaa Tyr Val Phe Gly Gln Asn Gly Lys Asp Xaa Lys Asp Ile Gly Leu 
    210                 215                 220                 


Ala Asn Asp Gly Ser Ile Xaa Gly Ile Asn Tyr Ala Xaa Ser Trp Tyr 
225                 230                 235                 240 


Glu Lys Trp Pro Lys Gly Met Gln Asp Thr Glu Gly Ala Gly Asn Leu 
                245                 250                 255     


Ile Gln Thr Xaa Phe Gln Glu Gly Lys Thr Ala Ala Ile Ile Asp Gly 
            260                 265                 270         


Pro Trp Lys Ala Gln Ala Phe Lys Asp Ala Lys Val Asn Tyr Gly Val 
        275                 280                 285             


Ala Thr Ile Pro Thr Leu Pro Asn Gly Lys Glu Tyr Ala Ala Phe Gly 
    290                 295                 300                 


Gly Gly Lys Ala Trp Val Ile Pro Gln Ala Val Lys Asn Leu Glu Ala 
305                 310                 315                 320 


Xaa Gln Lys Phe Val Asp Phe Leu Val Xaa Thr Glu Gln Gln Lys Xaa 
                325                 330                 335     


Leu Tyr Asp Lys Thr Asn Glu Ile Pro Ala Asn Thr Glu Ala Arg Ser 
            340                 345                 350         


Tyr Ala Glu Gly Lys Asn Asp Glu Leu Thr Thr Ala Val Ile Lys Gln 
        355                 360                 365             


Phe Lys Xaa Thr Gln Pro Leu Pro Asn Ile Ser Gln Met Ser Ala Val 
    370                 375                 380                 


Trp Asp Pro Ala Lys Asn Met Leu Phe Asp Ala Val Ser Gly Gln Lys 
385                 390                 395                 400 


Asp Ala Lys Thr Ala Ala Asn Asp Ala Val Thr Leu Ile Lys Glu Thr 
                405                 410                 415     


Ile Lys Gln Lys Phe Gly Glu 
            420             


<210>  9
<211>  99
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  9

Met Asn Gly Met Lys Ala Lys Lys Met Trp Met Ala Gly Leu Ala Leu 
1               5                   10                  15      


Leu Gly Ile Gly Ser Leu Ala Leu Ala Thr Lys Lys Val Ala Asp Asp 
            20                  25                  30          


Arg Lys Leu Met Lys Thr Gln Glu Glu Leu Thr Glu Ile Val Arg Asp 
        35                  40                  45              


His Phe Ser Asp Met Gly Glu Ile Ala Thr Leu Tyr Val Gln Val Tyr 
    50                  55                  60                  


Glu Ser Ser Leu Glu Ser Leu Val Gly Gly Val Ile Phe Glu Asp Gly 
65                  70                  75                  80  


Arg His Tyr Thr Phe Val Tyr Glu Asn Glu Asp Leu Val Tyr Glu Glu 
                85                  90                  95      


Glu Val Leu 
            


<210>  10
<211>  92
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  10

Met Arg Tyr Leu Ala Thr Leu Leu Leu Ser Leu Ala Val Leu Ile Thr 
1               5                   10                  15      


Ala Gly Cys Lys Lys Val Ala Asp Asp Arg Lys Leu Met Lys Thr Gln 
            20                  25                  30          


Glu Glu Leu Thr Glu Ile Val Arg Asp His Phe Ser Asp Met Gly Glu 
        35                  40                  45              


Ile Ala Thr Leu Tyr Val Gln Val Tyr Glu Ser Ser Leu Glu Ser Leu 
    50                  55                  60                  


Val Gly Gly Val Ile Phe Glu Asp Gly Arg His Tyr Thr Phe Val Tyr 
65                  70                  75                  80  


Glu Asn Glu Asp Leu Val Tyr Glu Glu Glu Val Leu 
                85                  90          


<210>  11
<211>  99
<212>  PRT
<213>  Streptococcus pneumoniae


<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  Arg or His

<220>
<221>  MOD_RES
<222>  (44)..(44)
<223>  Glu or Ala

<220>
<221>  MOD_RES
<222>  (49)..(49)
<223>  His or Leu

<220>
<221>  MOD_RES
<222>  (61)..(61)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (72)..(72)
<223>  Val or Leu

<220>
<221>  MOD_RES
<222>  (74)..(74)
<223>  Gly or ser

<220>
<221>  MOD_RES
<222>  (86)..(86)
<223>  Val or Ile

<400>  11

Met Asn Gly Met Lys Ala Lys Lys Met Trp Met Ala Gly Leu Ala Leu 
1               5                   10                  15      


Leu Gly Ile Gly Ser Leu Ala Leu Ala Thr Lys Lys Val Ala Asp Asp 
            20                  25                  30          


Xaa Lys Leu Met Lys Thr Gln Glu Glu Leu Thr Xaa Ile Val Arg Asp 
        35                  40                  45              


Xaa Phe Ser Asp Met Gly Glu Ile Ala Thr Leu Tyr Xaa Gln Val Tyr 
    50                  55                  60                  


Glu Ser Ser Leu Glu Ser Leu Xaa Gly Xaa Val Ile Phe Glu Asp Gly 
65                  70                  75                  80  


Arg His Tyr Thr Phe Xaa Tyr Glu Asn Glu Asp Leu Val Tyr Glu Glu 
                85                  90                  95      


Glu Val Leu 
            


<210>  12
<211>  2140
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  12

Met Lys Lys Ser Thr Val Leu Ser Leu Thr Thr Ala Ala Val Ile Leu 
1               5                   10                  15      


Ala Ala Tyr Ala Pro Asn Glu Val Val Leu Ala Asp Thr Ser Ser Ser 
            20                  25                  30          


Glu Asp Ala Leu Asn Ile Ser Asp Lys Glu Lys Val Ala Glu Asn Lys 
        35                  40                  45              


Glu Lys His Glu Asn Ile His Ser Ala Met Glu Thr Ser Gln Asp Phe 
    50                  55                  60                  


Lys Glu Lys Lys Thr Ala Val Ile Lys Glu Lys Glu Val Val Ser Lys 
65                  70                  75                  80  


Asn Pro Val Ile Asp Asn Asn Thr Ser Asn Glu Glu Ala Lys Ile Lys 
                85                  90                  95      


Glu Glu Asn Ser Asn Lys Ser Gln Gly Asp Tyr Thr Asp Ser Phe Val 
            100                 105                 110         


Asn Lys Asn Thr Glu Asn Pro Lys Lys Glu Asp Lys Val Val Tyr Ile 
        115                 120                 125             


Ala Glu Phe Lys Asp Lys Glu Ser Gly Glu Lys Ala Ile Lys Glu Leu 
    130                 135                 140                 


Ser Ser Leu Lys Asn Thr Lys Val Leu Tyr Thr Tyr Asp Arg Ile Phe 
145                 150                 155                 160 


Asn Gly Ser Ala Ile Glu Thr Thr Pro Asp Asn Leu Asp Lys Ile Lys 
                165                 170                 175     


Gln Ile Glu Gly Ile Ser Ser Val Glu Arg Ala Gln Lys Val Gln Pro 
            180                 185                 190         


Met Met Asn His Ala Arg Lys Glu Ile Gly Val Glu Glu Ala Ile Asp 
        195                 200                 205             


Tyr Leu Lys Ser Ile Asn Ala Pro Phe Gly Lys Asn Phe Asp Gly Arg 
    210                 215                 220                 


Gly Met Val Ile Ser Asn Ile Asp Thr Gly Thr Asp Tyr Arg His Lys 
225                 230                 235                 240 


Ala Met Arg Ile Asp Asp Asp Ala Lys Ala Ser Met Arg Phe Lys Lys 
                245                 250                 255     


Glu Asp Leu Lys Gly Thr Asp Lys Asn Tyr Trp Leu Ser Asp Lys Ile 
            260                 265                 270         


Pro His Ala Phe Asn Tyr Tyr Asn Gly Gly Lys Ile Thr Val Glu Lys 
        275                 280                 285             


Tyr Asp Asp Gly Arg Asp Tyr Phe Asp Pro His Gly Met His Ile Ala 
    290                 295                 300                 


Gly Ile Leu Ala Gly Asn Asp Thr Glu Gln Asp Ile Lys Asn Phe Asn 
305                 310                 315                 320 


Gly Ile Asp Gly Ile Ala Pro Asn Ala Gln Ile Phe Ser Tyr Lys Met 
                325                 330                 335     


Tyr Ser Asp Ala Gly Ser Gly Phe Ala Gly Asp Glu Thr Met Phe His 
            340                 345                 350         


Ala Ile Glu Asp Ser Ile Lys His Asn Val Asp Val Val Ser Val Ser 
        355                 360                 365             


Ser Gly Phe Thr Gly Thr Gly Leu Val Gly Glu Lys Tyr Trp Gln Ala 
    370                 375                 380                 


Ile Arg Ala Leu Arg Lys Ala Gly Ile Pro Met Val Val Ala Thr Gly 
385                 390                 395                 400 


Asn Tyr Ala Thr Ser Ala Ser Ser Ser Ser Trp Asp Leu Val Ala Asn 
                405                 410                 415     


Asn His Leu Lys Met Thr Asp Thr Gly Asn Val Thr Arg Thr Ala Ala 
            420                 425                 430         


His Glu Asp Ala Ile Ala Val Ala Ser Ala Lys Asn Gln Thr Val Glu 
        435                 440                 445             


Phe Asp Lys Val Asn Ile Gly Gly Glu Ser Phe Lys Tyr Arg Asn Ile 
    450                 455                 460                 


Gly Ala Phe Phe Asp Lys Ser Lys Ile Thr Thr Asn Glu Asp Gly Thr 
465                 470                 475                 480 


Lys Ala Pro Ser Lys Leu Lys Phe Val Tyr Ile Gly Lys Gly Gln Asp 
                485                 490                 495     


Gln Asp Leu Ile Gly Leu Asp Leu Arg Gly Lys Ile Ala Val Met Asp 
            500                 505                 510         


Arg Ile Tyr Thr Lys Asp Leu Lys Asn Ala Phe Lys Lys Ala Met Asp 
        515                 520                 525             


Lys Gly Ala Arg Ala Ile Met Val Val Asn Thr Val Asn Tyr Tyr Asn 
    530                 535                 540                 


Arg Asp Asn Trp Thr Glu Leu Pro Ala Met Gly Tyr Glu Ala Asp Glu 
545                 550                 555                 560 


Gly Thr Lys Ser Gln Val Phe Ser Ile Ser Gly Asp Asp Gly Val Lys 
                565                 570                 575     


Leu Trp Asn Met Ile Asn Pro Asp Lys Lys Thr Glu Val Lys Arg Asn 
            580                 585                 590         


Asn Lys Glu Asp Phe Lys Asp Lys Leu Glu Gln Tyr Tyr Pro Ile Asp 
        595                 600                 605             


Met Glu Ser Phe Asn Ser Asn Lys Pro Asn Val Gly Asp Glu Lys Glu 
    610                 615                 620                 


Ile Asp Phe Lys Phe Ala Pro Asp Thr Asp Lys Glu Leu Tyr Lys Glu 
625                 630                 635                 640 


Asp Ile Ile Val Pro Ala Gly Ser Thr Ser Trp Gly Pro Arg Ile Asp 
                645                 650                 655     


Leu Leu Leu Lys Pro Asp Val Ser Ala Pro Gly Lys Asn Ile Lys Ser 
            660                 665                 670         


Thr Leu Asn Val Ile Asn Gly Lys Ser Thr Tyr Gly Tyr Met Ser Gly 
        675                 680                 685             


Thr Ser Met Ala Thr Pro Ile Val Ala Ala Ser Thr Val Leu Ile Arg 
    690                 695                 700                 


Pro Lys Leu Lys Glu Met Leu Glu Arg Pro Val Leu Lys Asn Leu Lys 
705                 710                 715                 720 


Gly Asp Asp Lys Ile Asp Leu Thr Ser Leu Thr Lys Ile Ala Leu Gln 
                725                 730                 735     


Asn Thr Ala Arg Pro Met Met Asp Ala Thr Ser Trp Lys Glu Lys Ser 
            740                 745                 750         


Gln Tyr Phe Ala Ser Pro Arg Gln Gln Gly Ala Gly Leu Ile Asn Val 
        755                 760                 765             


Ala Asn Ala Leu Arg Asn Glu Val Val Ala Thr Phe Lys Asn Thr Asp 
    770                 775                 780                 


Ser Lys Gly Leu Val Asn Ser Tyr Gly Ser Ile Ser Leu Lys Glu Ile 
785                 790                 795                 800 


Lys Gly Asp Lys Lys Tyr Phe Thr Ile Lys Leu His Asn Thr Ser Asn 
                805                 810                 815     


Arg Pro Leu Thr Phe Lys Val Ser Ala Ser Ala Ile Thr Thr Asp Ser 
            820                 825                 830         


Leu Thr Asp Arg Leu Lys Leu Asp Glu Thr Tyr Lys Asp Glu Lys Ser 
        835                 840                 845             


Pro Asp Gly Lys Gln Ile Val Pro Glu Ile His Pro Glu Lys Val Lys 
    850                 855                 860                 


Gly Ala Asn Ile Thr Phe Glu His Asp Thr Phe Thr Ile Gly Ala Asn 
865                 870                 875                 880 


Ser Ser Phe Asp Leu Asn Ala Val Ile Asn Val Gly Glu Ala Lys Asn 
                885                 890                 895     


Lys Asn Lys Phe Val Glu Ser Phe Ile His Phe Glu Ser Val Glu Glu 
            900                 905                 910         


Met Glu Ala Leu Asn Ser Asn Gly Lys Lys Ile Asn Phe Gln Pro Ser 
        915                 920                 925             


Leu Ser Met Pro Leu Met Gly Phe Ala Gly Asn Trp Asn His Glu Pro 
    930                 935                 940                 


Ile Leu Asp Lys Trp Ala Trp Glu Glu Gly Ser Arg Ser Lys Thr Leu 
945                 950                 955                 960 


Gly Gly Tyr Asp Asp Asp Gly Lys Pro Lys Ile Pro Gly Thr Leu Asn 
                965                 970                 975     


Lys Gly Ile Gly Gly Glu His Gly Ile Asp Lys Phe Asn Pro Ala Gly 
            980                 985                 990         


Val Ile Gln Asn Arg Lys Asp Lys  Asn Thr Thr Ser Leu  Asp Gln Asn 
        995                 1000                 1005             


Pro Glu  Leu Phe Ala Phe Asn  Asn Glu Gly Ile Asn  Ala Pro Ser 
    1010                 1015                 1020             


Ser Ser  Gly Ser Lys Ile Ala  Asn Ile Tyr Pro Leu  Asp Ser Asn 
    1025                 1030                 1035             


Gly Asn  Pro Gln Asp Ala Gln  Leu Glu Arg Gly Leu  Thr Pro Ser 
    1040                 1045                 1050             


Pro Leu  Val Leu Arg Ser Ala  Glu Glu Gly Leu Ile  Ser Ile Val 
    1055                 1060                 1065             


Asn Thr  Asn Lys Glu Gly Glu  Asn Gln Arg Asp Leu  Lys Val Ile 
    1070                 1075                 1080             


Ser Arg  Glu His Phe Ile Arg  Gly Ile Leu Asn Ser  Lys Ser Asn 
    1085                 1090                 1095             


Asp Ala  Lys Gly Ile Lys Ser  Ser Lys Leu Lys Val  Trp Gly Asp 
    1100                 1105                 1110             


Leu Lys  Trp Asp Gly Leu Ile  Tyr Asn Pro Arg Gly  Arg Glu Glu 
    1115                 1120                 1125             


Asn Ala  Pro Glu Ser Lys Asp  Asn Gln Asp Pro Ala  Thr Lys Ile 
    1130                 1135                 1140             


Arg Gly  Gln Phe Glu Pro Ile  Ala Glu Gly Gln Tyr  Phe Tyr Lys 
    1145                 1150                 1155             


Phe Lys  Tyr Arg Leu Thr Lys  Asp Tyr Pro Trp Gln  Val Ser Tyr 
    1160                 1165                 1170             


Ile Pro  Val Lys Ile Asp Asn  Thr Ala Pro Lys Ile  Val Ser Val 
    1175                 1180                 1185             


Asp Phe  Ser Asn Pro Glu Lys  Ile Lys Leu Ile Thr  Lys Asp Thr 
    1190                 1195                 1200             


Tyr His  Lys Val Lys Asp Gln  Tyr Lys Asn Glu Thr  Leu Phe Ala 
    1205                 1210                 1215             


Arg Asp  Gln Lys Glu His Pro  Glu Lys Phe Asp Glu  Ile Ala Asn 
    1220                 1225                 1230             


Glu Val  Trp Tyr Ala Gly Ala  Ala Leu Val Asn Glu  Asp Gly Glu 
    1235                 1240                 1245             


Val Glu  Lys Asn Leu Glu Val  Thr Tyr Ala Gly Glu  Gly Gln Gly 
    1250                 1255                 1260             


Arg Asn  Arg Lys Leu Asp Lys  Asp Gly Asn Thr Ile  Tyr Glu Ile 
    1265                 1270                 1275             


Lys Gly  Ala Gly Asp Leu Arg  Gly Lys Ile Ile Glu  Val Ile Ala 
    1280                 1285                 1290             


Leu Asp  Gly Ser Ser Asn Phe  Thr Lys Ile His Arg  Ile Lys Phe 
    1295                 1300                 1305             


Ala Asn  Gln Ala Asp Glu Lys  Gly Met Ile Ser Tyr  Tyr Leu Val 
    1310                 1315                 1320             


Asp Pro  Asp Gln Asp Ser Ser  Lys Tyr Gln Lys Leu  Gly Glu Ile 
    1325                 1330                 1335             


Ala Glu  Ser Lys Phe Lys Asn  Leu Gly Asn Gly Lys  Glu Gly Ser 
    1340                 1345                 1350             


Leu Lys  Lys Asp Thr Thr Gly  Val Glu His His His  Gln Glu Asn 
    1355                 1360                 1365             


Glu Glu  Ser Ile Lys Glu Lys  Ser Ser Phe Thr Ile  Asp Arg Asn 
    1370                 1375                 1380             


Ile Ser  Thr Ile Arg Asp Phe  Glu Asn Lys Asp Leu  Lys Lys Leu 
    1385                 1390                 1395             


Ile Lys  Lys Lys Phe Arg Glu  Val Asp Asp Phe Thr  Ser Glu Thr 
    1400                 1405                 1410             


Gly Lys  Arg Met Glu Glu Tyr  Asp Tyr Lys Tyr Asp  Asp Lys Gly 
    1415                 1420                 1425             


Asn Ile  Ile Ala Tyr Asp Asp  Gly Thr Asp Leu Glu  Tyr Glu Thr 
    1430                 1435                 1440             


Glu Lys  Leu Asp Glu Ile Lys  Ser Lys Ile Tyr Gly  Val Leu Ser 
    1445                 1450                 1455             


Pro Ser  Lys Asp Gly His Phe  Glu Ile Leu Gly Lys  Ile Ser Asn 
    1460                 1465                 1470             


Val Ser  Lys Asn Ala Lys Val  Tyr Tyr Gly Asn Asn  Tyr Lys Ser 
    1475                 1480                 1485             


Ile Glu  Ile Lys Ala Thr Lys  Tyr Asp Phe His Ser  Lys Thr Met 
    1490                 1495                 1500             


Thr Phe  Asp Leu Tyr Ala Asn  Ile Asn Asp Ile Val  Asp Gly Leu 
    1505                 1510                 1515             


Ala Phe  Ala Gly Asp Met Arg  Leu Phe Val Lys Asp  Asn Asp Gln 
    1520                 1525                 1530             


Lys Lys  Ala Glu Ile Lys Ile  Arg Met Pro Glu Lys  Ile Lys Glu 
    1535                 1540                 1545             


Thr Lys  Ser Glu Tyr Pro Tyr  Val Ser Ser Tyr Gly  Asn Val Ile 
    1550                 1555                 1560             


Glu Leu  Gly Glu Gly Asp Leu  Ser Lys Asn Lys Pro  Asp Asn Leu 
    1565                 1570                 1575             


Thr Lys  Met Glu Ser Gly Lys  Ile Tyr Ser Asp Ser  Glu Lys Gln 
    1580                 1585                 1590             


Gln Tyr  Leu Leu Lys Asp Asn  Ile Ile Leu Arg Lys  Gly Tyr Ala 
    1595                 1600                 1605             


Leu Lys  Val Thr Thr Tyr Asn  Pro Gly Lys Thr Asp  Met Leu Glu 
    1610                 1615                 1620             


Gly Asn  Gly Val Tyr Ser Lys  Glu Asp Ile Ala Lys  Ile Gln Lys 
    1625                 1630                 1635             


Ala Asn  Pro Asn Leu Arg Ala  Leu Ser Glu Thr Thr  Ile Tyr Ala 
    1640                 1645                 1650             


Asp Ser  Arg Asn Val Glu Asp  Gly Arg Ser Thr Gln  Ser Val Leu 
    1655                 1660                 1665             


Met Ser  Ala Leu Asp Gly Phe  Asn Ile Ile Arg Tyr  Gln Val Phe 
    1670                 1675                 1680             


Thr Phe  Lys Met Asn Asp Lys  Gly Glu Ala Ile Asp  Lys Asp Gly 
    1685                 1690                 1695             


Asn Leu  Val Thr Asp Ser Ser  Lys Leu Val Leu Phe  Gly Lys Asp 
    1700                 1705                 1710             


Asp Lys  Glu Tyr Thr Gly Glu  Asp Lys Phe Asn Val  Glu Ala Ile 
    1715                 1720                 1725             


Lys Glu  Asp Gly Ser Met Leu  Phe Ile Asp Thr Lys  Pro Val Asn 
    1730                 1735                 1740             


Leu Ser  Met Asp Lys Asn Tyr  Phe Asn Pro Ser Lys  Ser Asn Lys 
    1745                 1750                 1755             


Ile Tyr  Val Arg Asn Pro Glu  Phe Tyr Leu Arg Gly  Lys Ile Ser 
    1760                 1765                 1770             


Asp Lys  Gly Gly Phe Asn Trp  Glu Leu Arg Val Asn  Glu Ser Val 
    1775                 1780                 1785             


Val Asp  Asn Tyr Leu Ile Tyr  Gly Asp Leu His Ile  Asp Asn Thr 
    1790                 1795                 1800             


Arg Asp  Phe Asn Ile Lys Leu  Asn Val Lys Asp Gly  Asp Ile Met 
    1805                 1810                 1815             


Asp Trp  Gly Met Lys Asp Tyr  Lys Ala Asn Gly Phe  Pro Asp Lys 
    1820                 1825                 1830             


Val Thr  Asp Met Asp Gly Asn  Val Tyr Leu Gln Thr  Gly Tyr Ser 
    1835                 1840                 1845             


Asp Leu  Asn Ala Lys Ala Val  Gly Val His Tyr Gln  Phe Leu Tyr 
    1850                 1855                 1860             


Asp Asn  Val Lys Pro Glu Val  Asn Ile Asp Pro Lys  Gly Asn Thr 
    1865                 1870                 1875             


Ser Ile  Glu Tyr Ala Asp Gly  Lys Ser Val Val Phe  Asn Ile Asn 
    1880                 1885                 1890             


Asp Lys  Arg Asn Asn Gly Phe  Asp Gly Glu Ile Gln  Glu Gln His 
    1895                 1900                 1905             


Ile Tyr  Ile Asn Gly Lys Glu  Tyr Thr Ser Phe Asn  Asp Ile Lys 
    1910                 1915                 1920             


Gln Ile  Ile Asp Lys Thr Leu  Asn Ile Lys Ile Val  Val Lys Asp 
    1925                 1930                 1935             


Phe Ala  Arg Asn Thr Thr Val  Lys Glu Phe Ile Leu  Asn Lys Asp 
    1940                 1945                 1950             


Thr Gly  Glu Val Ser Glu Leu  Lys Pro His Arg Val  Thr Val Thr 
    1955                 1960                 1965             


Ile Gln  Asn Gly Lys Glu Met  Ser Ser Thr Ile Val  Ser Glu Glu 
    1970                 1975                 1980             


Asp Phe  Ile Leu Pro Val Tyr  Lys Gly Glu Leu Glu  Lys Gly Tyr 
    1985                 1990                 1995             


Gln Phe  Asp Gly Trp Glu Ile  Ser Gly Phe Glu Gly  Lys Lys Asp 
    2000                 2005                 2010             


Ala Gly  Tyr Val Ile Asn Leu  Ser Lys Asp Thr Phe  Ile Lys Pro 
    2015                 2020                 2025             


Val Phe  Lys Lys Ile Glu Glu  Lys Lys Glu Glu Glu  Asn Lys Pro 
    2030                 2035                 2040             


Thr Phe  Asp Val Ser Lys Lys  Lys Asp Asn Pro Gln  Val Asn His 
    2045                 2050                 2055             


Ser Gln  Leu Asn Glu Ser His  Arg Lys Glu Asp Leu  Gln Arg Glu 
    2060                 2065                 2070             


Glu His  Ser Gln Lys Ser Asp  Ser Thr Lys Asp Val  Thr Ala Thr 
    2075                 2080                 2085             


Val Leu  Asp Lys Asn Asn Ile  Ser Ser Lys Ser Thr  Thr Asn Asn 
    2090                 2095                 2100             


Pro Asn  Lys Leu Pro Lys Thr  Gly Thr Ala Ser Gly  Ala Gln Thr 
    2105                 2110                 2115             


Leu Leu  Ala Ala Gly Ile Met  Phe Ile Val Gly Ile  Phe Leu Gly 
    2120                 2125                 2130             


Leu Lys  Lys Lys Asn Gln Asp  
    2135                 2140 


<210>  13
<211>  662
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  13

Met Val Val Leu Ala Asp Thr Ser Ser Ser Glu Asp Ala Leu Asn Ile 
1               5                   10                  15      


Ser Asp Lys Glu Lys Val Ala Glu Asn Lys Glu Lys His Glu Asn Ile 
            20                  25                  30          


His Ser Ala Met Glu Thr Ser Gln Asp Phe Lys Glu Lys Lys Thr Ala 
        35                  40                  45              


Val Ile Lys Glu Lys Glu Val Val Ser Lys Asn Pro Val Ile Asp Asn 
    50                  55                  60                  


Asn Thr Ser Asn Glu Glu Ala Lys Ile Lys Glu Glu Asn Ser Asn Lys 
65                  70                  75                  80  


Ser Gln Gly Asp Tyr Thr Asp Ser Phe Val Asn Lys Asn Thr Glu Asn 
                85                  90                  95      


Pro Lys Lys Glu Asp Lys Val Val Tyr Ile Ala Glu Phe Lys Asp Lys 
            100                 105                 110         


Glu Ser Gly Glu Lys Ala Ile Lys Glu Leu Ser Ser Leu Lys Asn Thr 
        115                 120                 125             


Lys Val Leu Tyr Thr Tyr Asp Arg Ile Phe Asn Gly Ser Ala Ile Glu 
    130                 135                 140                 


Thr Thr Pro Asp Asn Leu Asp Lys Ile Lys Gln Ile Glu Gly Ile Ser 
145                 150                 155                 160 


Ser Val Glu Arg Ala Gln Lys Val Gln Pro Met Met Asn His Ala Arg 
                165                 170                 175     


Lys Glu Ile Gly Val Glu Glu Ala Ile Asp Tyr Leu Lys Ser Ile Asn 
            180                 185                 190         


Ala Pro Phe Gly Lys Asn Phe Asp Gly Arg Gly Met Val Ile Ser Asn 
        195                 200                 205             


Ile Asp Thr Gly Thr Asp Tyr Arg His Lys Ala Met Arg Ile Asp Asp 
    210                 215                 220                 


Asp Ala Lys Ala Ser Met Arg Phe Lys Lys Glu Asp Leu Lys Gly Thr 
225                 230                 235                 240 


Asp Lys Asn Tyr Trp Leu Ser Asp Lys Ile Pro His Ala Phe Asn Tyr 
                245                 250                 255     


Tyr Asn Gly Gly Lys Ile Thr Val Glu Lys Tyr Asp Asp Gly Arg Asp 
            260                 265                 270         


Tyr Phe Asp Pro His Gly Met His Ile Ala Gly Ile Leu Ala Gly Asn 
        275                 280                 285             


Asp Thr Glu Gln Asp Ile Lys Asn Phe Asn Gly Ile Asp Gly Ile Ala 
    290                 295                 300                 


Pro Asn Ala Gln Ile Phe Ser Tyr Lys Met Tyr Ser Asp Ala Gly Ser 
305                 310                 315                 320 


Gly Phe Ala Gly Asp Glu Thr Met Phe His Ala Ile Glu Asp Ser Ile 
                325                 330                 335     


Lys His Asn Val Asp Val Val Ser Val Ser Ser Gly Phe Thr Gly Thr 
            340                 345                 350         


Gly Leu Val Gly Glu Lys Tyr Trp Gln Ala Ile Arg Ala Leu Arg Lys 
        355                 360                 365             


Ala Gly Ile Pro Met Val Val Ala Thr Gly Asn Tyr Ala Thr Ser Ala 
    370                 375                 380                 


Ser Ser Ser Ser Trp Asp Leu Val Ala Asn Asn His Leu Lys Met Thr 
385                 390                 395                 400 


Asp Thr Gly Asn Val Thr Arg Thr Ala Ala His Glu Asp Ala Ile Ala 
                405                 410                 415     


Val Ala Ser Ala Lys Asn Gln Thr Val Glu Phe Asp Lys Val Asn Ile 
            420                 425                 430         


Gly Gly Glu Ser Phe Lys Tyr Arg Asn Ile Gly Ala Phe Phe Asp Lys 
        435                 440                 445             


Ser Lys Ile Thr Thr Asn Glu Asp Gly Thr Lys Ala Pro Ser Lys Leu 
    450                 455                 460                 


Lys Phe Val Tyr Ile Gly Lys Gly Gln Asp Gln Asp Leu Ile Gly Leu 
465                 470                 475                 480 


Asp Leu Arg Gly Lys Ile Ala Val Met Asp Arg Ile Tyr Thr Lys Asp 
                485                 490                 495     


Leu Lys Asn Ala Phe Lys Lys Ala Met Asp Lys Gly Ala Arg Ala Ile 
            500                 505                 510         


Met Val Val Asn Thr Val Asn Tyr Tyr Asn Arg Asp Asn Trp Thr Glu 
        515                 520                 525             


Leu Pro Ala Met Gly Tyr Glu Ala Asp Glu Gly Thr Lys Ser Gln Val 
    530                 535                 540                 


Phe Ser Ile Ser Gly Asp Asp Gly Val Lys Leu Trp Asn Met Ile Asn 
545                 550                 555                 560 


Pro Asp Lys Lys Thr Glu Val Lys Arg Asn Asn Lys Glu Asp Phe Lys 
                565                 570                 575     


Asp Lys Leu Glu Gln Tyr Tyr Pro Ile Asp Met Glu Ser Phe Asn Ser 
            580                 585                 590         


Asn Lys Pro Asn Val Gly Asp Glu Lys Glu Ile Asp Phe Lys Phe Ala 
        595                 600                 605             


Pro Asp Thr Asp Lys Glu Leu Tyr Lys Glu Asp Ile Ile Val Pro Ala 
    610                 615                 620                 


Gly Ser Thr Ser Trp Gly Pro Arg Ile Asp Leu Leu Leu Lys Pro Asp 
625                 630                 635                 640 


Val Ser Ala Pro Gly Lys Asn Ile Lys Ser Thr Leu Asn Val Ile Asn 
                645                 650                 655     


Gly Lys Ser Thr Tyr Gly 
            660         


<210>  14
<211>  648
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  14

Met Ser Gly Thr Ser Met Ala Thr Pro Ile Val Ala Ala Ser Thr Val 
1               5                   10                  15      


Leu Ile Arg Pro Lys Leu Lys Glu Met Leu Glu Arg Pro Val Leu Lys 
            20                  25                  30          


Asn Leu Lys Gly Asp Asp Lys Ile Asp Leu Thr Ser Leu Thr Lys Ile 
        35                  40                  45              


Ala Leu Gln Asn Thr Ala Arg Pro Met Met Asp Ala Thr Ser Trp Lys 
    50                  55                  60                  


Glu Lys Ser Gln Tyr Phe Ala Ser Pro Arg Gln Gln Gly Ala Gly Leu 
65                  70                  75                  80  


Ile Asn Val Ala Asn Ala Leu Arg Asn Glu Val Val Ala Thr Phe Lys 
                85                  90                  95      


Asn Thr Asp Ser Lys Gly Leu Val Asn Ser Tyr Gly Ser Ile Ser Leu 
            100                 105                 110         


Lys Glu Ile Lys Gly Asp Lys Lys Tyr Phe Thr Ile Lys Leu His Asn 
        115                 120                 125             


Thr Ser Asn Arg Pro Leu Thr Phe Lys Val Ser Ala Ser Ala Ile Thr 
    130                 135                 140                 


Thr Asp Ser Leu Thr Asp Arg Leu Lys Leu Asp Glu Thr Tyr Lys Asp 
145                 150                 155                 160 


Glu Lys Ser Pro Asp Gly Lys Gln Ile Val Pro Glu Ile His Pro Glu 
                165                 170                 175     


Lys Val Lys Gly Ala Asn Ile Thr Phe Glu His Asp Thr Phe Thr Ile 
            180                 185                 190         


Gly Ala Asn Ser Ser Phe Asp Leu Asn Ala Val Ile Asn Val Gly Glu 
        195                 200                 205             


Ala Lys Asn Lys Asn Lys Phe Val Glu Ser Phe Ile His Phe Glu Ser 
    210                 215                 220                 


Val Glu Glu Met Glu Ala Leu Asn Ser Asn Gly Lys Lys Ile Asn Phe 
225                 230                 235                 240 


Gln Pro Ser Leu Ser Met Pro Leu Met Gly Phe Ala Gly Asn Trp Asn 
                245                 250                 255     


His Glu Pro Ile Leu Asp Lys Trp Ala Trp Glu Glu Gly Ser Arg Ser 
            260                 265                 270         


Lys Thr Leu Gly Gly Tyr Asp Asp Asp Gly Lys Pro Lys Ile Pro Gly 
        275                 280                 285             


Thr Leu Asn Lys Gly Ile Gly Gly Glu His Gly Ile Asp Lys Phe Asn 
    290                 295                 300                 


Pro Ala Gly Val Ile Gln Asn Arg Lys Asp Lys Asn Thr Thr Ser Leu 
305                 310                 315                 320 


Asp Gln Asn Pro Glu Leu Phe Ala Phe Asn Asn Glu Gly Ile Asn Ala 
                325                 330                 335     


Pro Ser Ser Ser Gly Ser Lys Ile Ala Asn Ile Tyr Pro Leu Asp Ser 
            340                 345                 350         


Asn Gly Asn Pro Gln Asp Ala Gln Leu Glu Arg Gly Leu Thr Pro Ser 
        355                 360                 365             


Pro Leu Val Leu Arg Ser Ala Glu Glu Gly Leu Ile Ser Ile Val Asn 
    370                 375                 380                 


Thr Asn Lys Glu Gly Glu Asn Gln Arg Asp Leu Lys Val Ile Ser Arg 
385                 390                 395                 400 


Glu His Phe Ile Arg Gly Ile Leu Asn Ser Lys Ser Asn Asp Ala Lys 
                405                 410                 415     


Gly Ile Lys Ser Ser Lys Leu Lys Val Trp Gly Asp Leu Lys Trp Asp 
            420                 425                 430         


Gly Leu Ile Tyr Asn Pro Arg Gly Arg Glu Glu Asn Ala Pro Glu Ser 
        435                 440                 445             


Lys Asp Asn Gln Asp Pro Ala Thr Lys Ile Arg Gly Gln Phe Glu Pro 
    450                 455                 460                 


Ile Ala Glu Gly Gln Tyr Phe Tyr Lys Phe Lys Tyr Arg Leu Thr Lys 
465                 470                 475                 480 


Asp Tyr Pro Trp Gln Val Ser Tyr Ile Pro Val Lys Ile Asp Asn Thr 
                485                 490                 495     


Ala Pro Lys Ile Val Ser Val Asp Phe Ser Asn Pro Glu Lys Ile Lys 
            500                 505                 510         


Leu Ile Thr Lys Asp Thr Tyr His Lys Val Lys Asp Gln Tyr Lys Asn 
        515                 520                 525             


Glu Thr Leu Phe Ala Arg Asp Gln Lys Glu His Pro Glu Lys Phe Asp 
    530                 535                 540                 


Glu Ile Ala Asn Glu Val Trp Tyr Ala Gly Ala Ala Leu Val Asn Glu 
545                 550                 555                 560 


Asp Gly Glu Val Glu Lys Asn Leu Glu Val Thr Tyr Ala Gly Glu Gly 
                565                 570                 575     


Gln Gly Arg Asn Arg Lys Leu Asp Lys Asp Gly Asn Thr Ile Tyr Glu 
            580                 585                 590         


Ile Lys Gly Ala Gly Asp Leu Arg Gly Lys Ile Ile Glu Val Ile Ala 
        595                 600                 605             


Leu Asp Gly Ser Ser Asn Phe Thr Lys Ile His Arg Ile Lys Phe Ala 
    610                 615                 620                 


Asn Gln Ala Asp Glu Lys Gly Met Ile Ser Tyr Tyr Leu Val Asp Pro 
625                 630                 635                 640 


Asp Gln Asp Ser Ser Lys Tyr Gln 
                645             


<210>  15
<211>  667
<212>  PRT
<213>  Streptococcus pneumoniae


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  May or may not be present

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Ser or Asn

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asn or Ser

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Ala or Val

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Val or Leu or not present

<220>
<221>  MOD_RES
<222>  (25)..(28)
<223>  May or may not be present

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  Glu or Lys

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  Asn or Asp

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Ser or Asn

<220>
<221>  MOD_RES
<222>  (41)..(41)
<223>  Met or Ile

<220>
<221>  MOD_RES
<222>  (45)..(45)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (47)..(47)
<223>  Phe or Thr

<220>
<221>  MOD_RES
<222>  (48)..(48)
<223>  Lys or Glu

<220>
<221>  MOD_RES
<222>  (53)..(53)
<223>  Ala or Thr

<220>
<221>  MOD_RES
<222>  (54)..(54)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (56)..(56)
<223>  Lys or Glu

<220>
<221>  MOD_RES
<222>  (57)..(57)
<223>  Glu or Gly

<220>
<221>  MOD_RES
<222>  (59)..(59)
<223>  Glu or Ala

<220>
<221>  MOD_RES
<222>  (67)..(67)
<223>  Ile or Thr

<220>
<221>  MOD_RES
<222>  (69)..(69)
<223>  Asn or Thr

<220>
<221>  MOD_RES
<222>  (70)..(70)
<223>  Asn or Lys

<220>
<221>  MOD_RES
<222>  (77)..(77)
<223>  Lys or Arg

<220>
<221>  MOD_RES
<222>  (81)..(81)
<223>  Glu or Asp

<220>
<221>  MOD_RES
<222>  (82)..(82)
<223>  May or may not be present

<220>
<221>  MOD_RES
<222>  (85)..(85)
<223>  Lys or Gln

<220>
<221>  MOD_RES
<222>  (90)..(90)
<223>  Tyr, His or Asn

<220>
<221>  MOD_RES
<222>  (91)..(91)
<223>  Thr or Ala

<220>
<221>  MOD_RES
<222>  (92)..(92)
<223>  Asp or His

<220>
<221>  MOD_RES
<222>  (94)..(94)
<223>  Phe or Ser

<220>
<221>  MOD_RES
<222>  (95)..(95)
<223>  Val or Ala

<220>
<221>  MOD_RES
<222>  (98)..(98)
<223>  Asn or Gly

<220>
<221>  MOD_RES
<222>  (105)..(105)
<223>  Glu or Gln

<220>
<221>  MOD_RES
<222>  (107)..(107)
<223>  Lys or Arg

<220>
<221>  MOD_RES
<222>  (108)..(108)
<223>  Val or Leu

<220>
<221>  MOD_RES
<222>  (121)..(121)
<223>  Glu or Ser

<220>
<221>  MOD_RES
<222>  (126)..(126)
<223>  Glu, Gln or Gly

<220>
<221>  MOD_RES
<222>  (129)..(129)
<223>  Ser or Asn

<220>
<221>  MOD_RES
<222>  (146)..(146)
<223>  Ser or Gly

<220>
<221>  MOD_RES
<222>  (152)..(152)
<223>  Pro or Gln

<220>
<221>  MOD_RES
<222>  (165)..(165)
<223>  Ser or Thr

<220>
<221>  MOD_RES
<222>  (167)..(167)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (440)..(440)
<223>  Glu or Gln

<220>
<221>  MOD_RES
<222>  (454)..(454)
<223>  Ser or Asn

<220>
<221>  MOD_RES
<222>  (567)..(567)
<223>  Asp or Asn

<400>  15

Met Val Val Leu Ala Asp Thr Ser Xaa Ser Glu Asp Ala Leu Xaa Ile 
1               5                   10                  15      


Ser Asp Lys Glu Lys Val Xaa Xaa Asp Lys Glu Thr Glu Asn Lys Glu 
            20                  25                  30          


Lys His Xaa Xaa Ile His Xaa Ala Xaa Glu Thr Ser Xaa Asp Xaa Xaa 
        35                  40                  45              


Glu Lys Lys Thr Xaa Xaa Ile Xaa Xaa Lys Xaa Val Val Ser Lys Asn 
    50                  55                  60                  


Pro Val Xaa Asp Xaa Xaa Thr Ser Asn Glu Glu Ala Xaa Ile Lys Glu 
65                  70                  75                  80  


Xaa Asn Ser Asn Xaa Ser Gln Gly Asp Xaa Xaa Xaa Ser Xaa Xaa Asn 
                85                  90                  95      


Lys Xaa Thr Glu Asn Pro Lys Lys Xaa Asp Xaa Xaa Val Tyr Ile Ala 
            100                 105                 110         


Glu Phe Lys Asp Lys Glu Ser Gly Xaa Lys Ala Ile Lys Xaa Leu Ser 
        115                 120                 125             


Xaa Leu Lys Asn Thr Lys Val Leu Tyr Thr Tyr Asp Arg Ile Phe Asn 
    130                 135                 140                 


Gly Xaa Ala Ile Glu Thr Thr Xaa Asp Asn Leu Asp Lys Ile Lys Gln 
145                 150                 155                 160 


Ile Glu Gly Ile Xaa Ser Xaa Glu Arg Ala Gln Lys Val Gln Pro Met 
                165                 170                 175     


Met Asn His Ala Arg Lys Glu Ile Gly Val Glu Glu Ala Ile Asp Tyr 
            180                 185                 190         


Leu Lys Ser Ile Asn Ala Pro Phe Gly Lys Asn Phe Asp Gly Arg Gly 
        195                 200                 205             


Met Val Ile Ser Asn Ile Asp Thr Gly Thr Asp Tyr Arg His Lys Ala 
    210                 215                 220                 


Met Arg Ile Asp Asp Asp Ala Lys Ala Ser Met Arg Phe Lys Lys Glu 
225                 230                 235                 240 


Asp Leu Lys Gly Thr Asp Lys Asn Tyr Trp Leu Ser Asp Lys Ile Pro 
                245                 250                 255     


His Ala Phe Asn Tyr Tyr Asn Gly Gly Lys Ile Thr Val Glu Lys Tyr 
            260                 265                 270         


Asp Asp Gly Arg Asp Tyr Phe Asp Pro His Gly Met His Ile Ala Gly 
        275                 280                 285             


Ile Leu Ala Gly Asn Asp Thr Glu Gln Asp Ile Lys Asn Phe Asn Gly 
    290                 295                 300                 


Ile Asp Gly Ile Ala Pro Asn Ala Gln Ile Phe Ser Tyr Lys Met Tyr 
305                 310                 315                 320 


Ser Asp Ala Gly Ser Gly Phe Ala Gly Asp Glu Thr Met Phe His Ala 
                325                 330                 335     


Ile Glu Asp Ser Ile Lys His Asn Val Asp Val Val Ser Val Ser Ser 
            340                 345                 350         


Gly Phe Thr Gly Thr Gly Leu Val Gly Glu Lys Tyr Trp Gln Ala Ile 
        355                 360                 365             


Arg Ala Leu Arg Lys Ala Gly Ile Pro Met Val Val Ala Thr Gly Asn 
    370                 375                 380                 


Tyr Ala Thr Ser Ala Ser Ser Ser Ser Trp Asp Leu Val Ala Asn Asn 
385                 390                 395                 400 


His Leu Lys Met Thr Asp Thr Gly Asn Val Thr Arg Thr Ala Ala His 
                405                 410                 415     


Glu Asp Ala Ile Ala Val Ala Ser Ala Lys Asn Gln Thr Val Glu Phe 
            420                 425                 430         


Asp Lys Val Asn Ile Gly Gly Xaa Ser Phe Lys Tyr Arg Asn Ile Gly 
        435                 440                 445             


Ala Phe Phe Asp Lys Xaa Lys Ile Thr Thr Asn Glu Asp Gly Thr Lys 
    450                 455                 460                 


Ala Pro Ser Lys Leu Lys Phe Val Tyr Ile Gly Lys Gly Gln Asp Gln 
465                 470                 475                 480 


Asp Leu Ile Gly Leu Asp Leu Arg Gly Lys Ile Ala Val Met Asp Arg 
                485                 490                 495     


Ile Tyr Thr Lys Asp Leu Lys Asn Ala Phe Lys Lys Ala Met Asp Lys 
            500                 505                 510         


Gly Ala Arg Ala Ile Met Val Val Asn Thr Val Asn Tyr Tyr Asn Arg 
        515                 520                 525             


Asp Asn Trp Thr Glu Leu Pro Ala Met Gly Tyr Glu Ala Asp Glu Gly 
    530                 535                 540                 


Thr Lys Ser Gln Val Phe Ser Ile Ser Gly Asp Asp Gly Val Lys Leu 
545                 550                 555                 560 


Trp Asn Met Ile Asn Pro Xaa Lys Lys Thr Glu Val Lys Arg Asn Asn 
                565                 570                 575     


Lys Glu Asp Phe Lys Asp Lys Leu Glu Gln Tyr Tyr Pro Ile Asp Met 
            580                 585                 590         


Glu Ser Phe Asn Ser Asn Lys Pro Asn Val Gly Asp Glu Lys Glu Ile 
        595                 600                 605             


Asp Phe Lys Phe Ala Pro Asp Thr Asp Lys Glu Leu Tyr Lys Glu Asp 
    610                 615                 620                 


Ile Ile Val Pro Ala Gly Ser Thr Ser Trp Gly Pro Arg Ile Asp Leu 
625                 630                 635                 640 


Leu Leu Lys Pro Asp Val Ser Ala Pro Gly Lys Asn Ile Lys Ser Thr 
                645                 650                 655     


Leu Asn Val Ile Asn Gly Lys Ser Thr Tyr Gly 
            660                 665         


<210>  16
<211>  648
<212>  PRT
<213>  Streptococcus pneumoniae


<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Arg or Lys

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  Lys or Thr

<220>
<221>  MOD_RES
<222>  (143)..(143)
<223>  Ile or Val

<220>
<221>  MOD_RES
<222>  (165)..(165)
<223>  Asp or Tyr

<220>
<221>  MOD_RES
<222>  (210)..(210)
<223>  Lys or Arg

<220>
<221>  MOD_RES
<222>  (227)..(227)
<223>  Glu or Ala

<220>
<221>  MOD_RES
<222>  (232)..(232)
<223>  Asn or Ser

<220>
<221>  MOD_RES
<222>  (238)..(238)
<223>  Ile or Thr

<220>
<221>  MOD_RES
<222>  (239)..(239)
<223>  Asn or Asp

<220>
<221>  MOD_RES
<222>  (271)..(271)
<223>  Arg or Lys

<220>
<221>  MOD_RES
<222>  (275)..(275)
<223>  Leu or Met

<220>
<221>  MOD_RES
<222>  (276)..(276)
<223>  Gly or Glu

<220>
<221>  MOD_RES
<222>  (317)..(317)
<223>  Thr or Arg

<220>
<221>  MOD_RES
<222>  (323)..(323)
<223>  Asn or Asp

<220>
<221>  MOD_RES
<222>  (325)..(325)
<223>  Glu or Asp

<220>
<221>  MOD_RES
<222>  (332)..(332)
<223>  Glu or Gln

<220>
<221>  MOD_RES
<222>  (334)..(334)
<223>  Ile or Val

<220>
<221>  MOD_RES
<222>  (335)..(335)
<223>  Asn or His

<220>
<221>  MOD_RES
<222>  (337)..(337)
<223>  Pro or Glu

<220>
<221>  MOD_RES
<222>  (339)..(339)
<223>  Ser or Thr

<220>
<221>  MOD_RES
<222>  (393)..(393)
<223>  Arg or Lys

<220>
<221>  MOD_RES
<222>  (398)..(398)
<223>  Ile or Val

<220>
<221>  MOD_RES
<222>  (412)..(412)
<223>  Ser or Gly

<220>
<221>  MOD_RES
<222>  (594)..(594)
<223>  Lys or Ser

<220>
<221>  MOD_RES
<222>  (612)..(612)
<223>  Ser or Ala

<220>
<221>  MOD_RES
<222>  (625)..(625)
<223>  Asn or Asp

<220>
<221>  MOD_RES
<222>  (626)..(626)
<223>  Gln or His

<220>
<221>  MOD_RES
<222>  (642)..(642)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (644)..(644)
<223>  Ser or Ala

<220>
<221>  MOD_RES
<222>  (648)..(648)
<223>  Gln or Glu

<400>  16

Met Ser Gly Thr Ser Met Ala Thr Pro Ile Val Ala Ala Ser Thr Val 
1               5                   10                  15      


Leu Ile Arg Pro Lys Leu Lys Glu Met Leu Glu Xaa Pro Val Leu Lys 
            20                  25                  30          


Asn Leu Xaa Gly Asp Asp Lys Ile Asp Leu Thr Ser Leu Thr Lys Ile 
        35                  40                  45              


Ala Leu Gln Asn Thr Ala Arg Pro Met Met Asp Ala Thr Ser Trp Lys 
    50                  55                  60                  


Glu Lys Ser Gln Tyr Phe Ala Ser Pro Arg Gln Gln Gly Ala Gly Leu 
65                  70                  75                  80  


Ile Asn Val Ala Asn Ala Leu Arg Asn Glu Val Val Ala Thr Phe Lys 
                85                  90                  95      


Asn Thr Asp Ser Lys Gly Leu Val Asn Ser Tyr Gly Ser Ile Ser Leu 
            100                 105                 110         


Lys Glu Ile Lys Gly Asp Lys Lys Tyr Phe Thr Ile Lys Leu His Asn 
        115                 120                 125             


Thr Ser Asn Arg Pro Leu Thr Phe Lys Val Ser Ala Ser Ala Xaa Thr 
    130                 135                 140                 


Thr Asp Ser Leu Thr Asp Arg Leu Lys Leu Asp Glu Thr Tyr Lys Asp 
145                 150                 155                 160 


Glu Lys Ser Pro Xaa Gly Lys Gln Ile Val Pro Glu Ile His Pro Glu 
                165                 170                 175     


Lys Val Lys Gly Ala Asn Ile Thr Phe Glu His Asp Thr Phe Thr Ile 
            180                 185                 190         


Gly Ala Asn Ser Ser Phe Asp Leu Asn Ala Val Ile Asn Val Gly Glu 
        195                 200                 205             


Ala Xaa Asn Lys Asn Lys Phe Val Glu Ser Phe Ile His Phe Glu Ser 
    210                 215                 220                 


Val Glu Xaa Met Glu Ala Leu Xaa Ser Asn Gly Lys Lys Xaa Xaa Phe 
225                 230                 235                 240 


Gln Pro Ser Leu Ser Met Pro Leu Met Gly Phe Ala Gly Asn Trp Asn 
                245                 250                 255     


His Glu Pro Ile Leu Asp Lys Trp Ala Trp Glu Glu Gly Ser Xaa Ser 
            260                 265                 270         


Lys Thr Xaa Xaa Gly Tyr Asp Asp Asp Gly Lys Pro Lys Ile Pro Gly 
        275                 280                 285             


Thr Leu Asn Lys Gly Ile Gly Gly Glu His Gly Ile Asp Lys Phe Asn 
    290                 295                 300                 


Pro Ala Gly Val Ile Gln Asn Arg Lys Asp Lys Asn Xaa Thr Ser Leu 
305                 310                 315                 320 


Asp Gln Xaa Pro Xaa Leu Phe Ala Phe Asn Asn Xaa Gly Xaa Xaa Ala 
                325                 330                 335     


Xaa Ser Xaa Ser Gly Ser Lys Ile Ala Asn Ile Tyr Pro Leu Asp Ser 
            340                 345                 350         


Asn Gly Asn Pro Gln Asp Ala Gln Leu Glu Arg Gly Leu Thr Pro Ser 
        355                 360                 365             


Pro Leu Val Leu Arg Ser Ala Glu Glu Gly Leu Ile Ser Ile Val Asn 
    370                 375                 380                 


Thr Asn Lys Glu Gly Glu Asn Gln Xaa Asp Leu Lys Val Xaa Ser Arg 
385                 390                 395                 400 


Glu His Phe Ile Arg Gly Ile Leu Asn Ser Lys Xaa Asn Asp Ala Lys 
                405                 410                 415     


Gly Ile Lys Ser Ser Lys Leu Lys Val Trp Gly Asp Leu Lys Trp Asp 
            420                 425                 430         


Gly Leu Ile Tyr Asn Pro Arg Gly Arg Glu Glu Asn Ala Pro Glu Ser 
        435                 440                 445             


Lys Asp Asn Gln Asp Pro Ala Thr Lys Ile Arg Gly Gln Phe Glu Pro 
    450                 455                 460                 


Ile Ala Glu Gly Gln Tyr Phe Tyr Lys Phe Lys Tyr Arg Leu Thr Lys 
465                 470                 475                 480 


Asp Tyr Pro Trp Gln Val Ser Tyr Ile Pro Val Lys Ile Asp Asn Thr 
                485                 490                 495     


Ala Pro Lys Ile Val Ser Val Asp Phe Ser Asn Pro Glu Lys Ile Lys 
            500                 505                 510         


Leu Ile Thr Lys Asp Thr Tyr His Lys Val Lys Asp Gln Tyr Lys Asn 
        515                 520                 525             


Glu Thr Leu Phe Ala Arg Asp Gln Lys Glu His Pro Glu Lys Phe Asp 
    530                 535                 540                 


Glu Ile Ala Asn Glu Val Trp Tyr Ala Gly Ala Ala Leu Val Asn Glu 
545                 550                 555                 560 


Asp Gly Glu Val Glu Lys Asn Leu Glu Val Thr Tyr Ala Gly Glu Gly 
                565                 570                 575     


Gln Gly Arg Asn Arg Lys Leu Asp Lys Asp Gly Asn Thr Ile Tyr Glu 
            580                 585                 590         


Ile Xaa Gly Ala Gly Asp Leu Arg Gly Lys Ile Ile Glu Val Ile Ala 
        595                 600                 605             


Leu Asp Gly Xaa Ser Asn Phe Thr Lys Ile His Arg Ile Lys Phe Ala 
    610                 615                 620                 


Xaa Xaa Ala Asp Glu Lys Gly Met Ile Ser Tyr Tyr Leu Val Asp Pro 
625                 630                 635                 640 


Asp Xaa Asp Xaa Ser Lys Tyr Xaa 
                645             


<210>  17
<211>  274
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  17

Met Asn Gln Ser Tyr Phe Tyr Leu Lys Met Lys Glu His Lys Leu Lys 
1               5                   10                  15      


Val Pro Tyr Thr Gly Lys Glu Arg Arg Val Arg Ile Leu Leu Pro Lys 
            20                  25                  30          


Asp Tyr Glu Lys Asp Thr Asp Arg Ser Tyr Pro Val Val Tyr Phe His 
        35                  40                  45              


Asp Gly Gln Asn Val Phe Asn Ser Lys Glu Ser Phe Ile Gly His Ser 
    50                  55                  60                  


Trp Lys Ile Ile Pro Ala Ile Lys Arg Asn Pro Asp Ile Ser Arg Met 
65                  70                  75                  80  


Ile Val Val Ala Ile Asp Asn Asp Gly Met Gly Arg Met Asn Glu Tyr 
                85                  90                  95      


Ala Ala Trp Lys Phe Gln Glu Ser Pro Ile Pro Gly Gln Gln Phe Gly 
            100                 105                 110         


Gly Lys Gly Val Glu Tyr Ala Glu Phe Val Met Glu Val Val Lys Pro 
        115                 120                 125             


Phe Ile Asp Glu Thr Tyr Arg Thr Lys Ala Asp Cys Gln His Thr Ala 
    130                 135                 140                 


Met Ile Gly Ser Ser Leu Gly Gly Asn Ile Thr Gln Phe Ile Gly Leu 
145                 150                 155                 160 


Glu Tyr Gln Asp Gln Ile Gly Cys Leu Gly Val Phe Ser Ser Ala Asn 
                165                 170                 175     


Trp Leu His Gln Glu Ala Phe Asn Arg Tyr Phe Glu Cys Gln Lys Leu 
            180                 185                 190         


Ser Pro Asp Gln Arg Ile Phe Ile Tyr Val Gly Thr Glu Glu Ala Asp 
        195                 200                 205             


Asp Thr Asp Lys Thr Leu Met Asp Gly Asn Ile Lys Gln Ala Tyr Ile 
    210                 215                 220                 


Asp Ser Ser Leu Cys Tyr Tyr His Asp Leu Ile Ala Gly Gly Val His 
225                 230                 235                 240 


Leu Asp Asn Leu Val Leu Lys Val Gln Ser Gly Ala Ile His Ser Glu 
                245                 250                 255     


Ile Pro Trp Ser Glu Asn Leu Pro Asp Cys Leu Arg Phe Phe Ala Glu 
            260                 265                 270         


Lys Trp 
        


<210>  18
<211>  130
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  18

Met Asn Gln Ser Tyr Phe Tyr Leu Lys Met Lys Glu His Lys Leu Lys 
1               5                   10                  15      


Val Pro Tyr Thr Gly Lys Glu Arg Arg Val Arg Ile Leu Leu Pro Lys 
            20                  25                  30          


Asp Tyr Glu Lys Asp Thr Asp Arg Ser Tyr Pro Val Val Tyr Phe His 
        35                  40                  45              


Asp Gly Gln Asn Val Phe Asn Ser Lys Glu Ser Phe Ile Gly His Ser 
    50                  55                  60                  


Trp Lys Ile Ile Pro Ala Ile Lys Arg Asn Pro Asp Ile Ser Arg Met 
65                  70                  75                  80  


Ile Val Val Ala Ile Asp Asn Asp Gly Met Gly Arg Met Asn Glu Tyr 
                85                  90                  95      


Ala Ala Trp Lys Phe Gln Glu Ser Pro Ile Pro Gly Gln Gln Phe Gly 
            100                 105                 110         


Gly Lys Gly Val Glu Tyr Ala Glu Phe Val Met Glu Val Val Lys Pro 
        115                 120                 125             


Phe Ile 
    130 


<210>  19
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP0882 with exogenous signal sequence

<400>  19

Met Ser Ser Lys Phe Met Lys Ser Ala Ala Val Leu Gly Thr Ala Thr 
1               5                   10                  15      


Leu Ala Ser Leu Leu Leu Val Ala Cys Met Asn Gln Ser Tyr Phe Tyr 
            20                  25                  30          


Leu Lys Met Lys Glu His Lys Leu Lys Val Pro Tyr Thr Gly Lys Glu 
        35                  40                  45              


Arg Arg Val Arg Ile Leu Leu Pro Lys Asp Tyr Glu Lys Asp Thr Asp 
    50                  55                  60                  


Arg Ser Tyr Pro Val Val Tyr Phe His Asp Gly Gln Asn Val Phe Asn 
65                  70                  75                  80  


Ser Lys Glu Ser Phe Ile Gly His Ser Trp Lys Ile Ile Pro Ala Ile 
                85                  90                  95      


Lys Arg Asn Pro Asp Ile Ser Arg Met Ile Val Val Ala Ile Asp Asn 
            100                 105                 110         


Asp Gly Met Gly Arg Met Asn Glu Tyr Ala Ala Trp Lys Phe Gln Glu 
        115                 120                 125             


Ser Pro Ile Pro Gly Gln Gln Phe Gly Gly Lys Gly Val Glu Tyr Ala 
    130                 135                 140                 


Glu Phe Val Met Glu Val Val Lys Pro Phe Ile Asp Glu Thr Tyr Arg 
145                 150                 155                 160 


Thr Lys Ala Asp Cys Gln His Thr Ala Met Ile Gly Ser Ser Leu Gly 
                165                 170                 175     


Gly Asn Ile Thr Gln Phe Ile Gly Leu Glu Tyr Gln Asp Gln Ile Gly 
            180                 185                 190         


Cys Leu Gly Val Phe Ser Ser Ala Asn Trp Leu His Gln Glu Ala Phe 
        195                 200                 205             


Asn Arg Tyr Phe Glu Cys Gln Lys Leu Ser Pro Asp Gln Arg Ile Phe 
    210                 215                 220                 


Ile Tyr Val Gly Thr Glu Glu Ala Asp Asp Thr Asp Lys Thr Leu Met 
225                 230                 235                 240 


Asp Gly Asn Ile Lys Gln Ala Tyr Ile Asp Ser Ser Leu Cys Tyr Tyr 
                245                 250                 255     


His Asp Leu Ile Ala Gly Gly Val His Leu Asp Asn Leu Val Leu Lys 
            260                 265                 270         


Val Gln Ser Gly Ala Ile His Ser Glu Ile Pro Trp Ser Glu Asn Leu 
        275                 280                 285             


Pro Asp Cys Leu Arg Phe Phe Ala Glu Lys Trp 
    290                 295                 


<210>  20
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP0882N with exogenous signal sequence

<400>  20

Met Ser Ser Lys Phe Met Lys Ser Ala Ala Val Leu Gly Thr Ala Thr 
1               5                   10                  15      


Leu Ala Ser Leu Leu Leu Val Ala Cys Met Asn Gln Ser Tyr Phe Tyr 
            20                  25                  30          


Leu Lys Met Lys Glu His Lys Leu Lys Val Pro Tyr Thr Gly Lys Glu 
        35                  40                  45              


Arg Arg Val Arg Ile Leu Leu Pro Lys Asp Tyr Glu Lys Asp Thr Asp 
    50                  55                  60                  


Arg Ser Tyr Pro Val Val Tyr Phe His Asp Gly Gln Asn Val Phe Asn 
65                  70                  75                  80  


Ser Lys Glu Ser Phe Ile Gly His Ser Trp Lys Ile Ile Pro Ala Ile 
                85                  90                  95      


Lys Arg Asn Pro Asp Ile Ser Arg Met Ile Val Val Ala Ile Asp Asn 
            100                 105                 110         


Asp Gly Met Gly Arg Met Asn Glu Tyr Ala Ala Trp Lys Phe Gln Glu 
        115                 120                 125             


Ser Pro Ile Pro Gly Gln Gln Phe Gly Gly Lys Gly Val Glu Tyr Ala 
    130                 135                 140                 


Glu Phe Val Met Glu Val Val Lys Pro Phe Ile 
145                 150                 155 


<210>  21
<211>  274
<212>  PRT
<213>  Streptococcus pneumoniae


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Met or Ile

<220>
<221>  MOD_RES
<222>  (55)..(55)
<223>  Asn or Tyr

<220>
<221>  MOD_RES
<222>  (63)..(63)
<223>  His or Tyr

<220>
<221>  MOD_RES
<222>  (79)..(79)
<223>  Arg or His

<220>
<221>  MOD_RES
<222>  (97)..(97)
<223>  Ala or Glu

<220>
<221>  MOD_RES
<222>  (108)..(108)
<223>  Gly or Glu

<220>
<221>  MOD_RES
<222>  (164)..(164)
<223>  Asp or Glu

<220>
<221>  MOD_RES
<222>  (165)..(165)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (187)..(187)
<223>  Phe or Ile

<220>
<221>  MOD_RES
<222>  (197)..(197)
<223>  Arg or His

<220>
<221>  MOD_RES
<222>  (238)..(238)
<223>  Gly or Arg

<400>  21

Xaa Asn Gln Ser Tyr Phe Tyr Leu Lys Met Lys Glu His Lys Leu Lys 
1               5                   10                  15      


Val Pro Tyr Thr Gly Lys Glu Arg Arg Val Arg Ile Leu Leu Pro Lys 
            20                  25                  30          


Asp Tyr Glu Lys Asp Thr Asp Arg Ser Tyr Pro Val Val Tyr Phe His 
        35                  40                  45              


Asp Gly Gln Asn Val Phe Xaa Ser Lys Glu Ser Phe Ile Gly Xaa Ser 
    50                  55                  60                  


Trp Lys Ile Ile Pro Ala Ile Lys Arg Asn Pro Asp Ile Ser Xaa Met 
65                  70                  75                  80  


Ile Val Val Ala Ile Asp Asn Asp Gly Met Gly Arg Met Asn Glu Tyr 
                85                  90                  95      


Xaa Ala Trp Lys Phe Gln Glu Ser Pro Ile Pro Xaa Gln Gln Phe Gly 
            100                 105                 110         


Gly Lys Gly Val Glu Tyr Ala Glu Phe Val Met Glu Val Val Lys Pro 
        115                 120                 125             


Phe Ile Asp Glu Thr Tyr Arg Thr Lys Ala Asp Cys Gln His Thr Ala 
    130                 135                 140                 


Met Ile Gly Ser Ser Leu Gly Gly Asn Ile Thr Gln Phe Ile Gly Leu 
145                 150                 155                 160 


Glu Tyr Gln Xaa Xaa Ile Gly Cys Leu Gly Val Phe Ser Ser Ala Asn 
                165                 170                 175     


Trp Leu His Gln Glu Ala Phe Asn Arg Tyr Xaa Glu Cys Gln Lys Leu 
            180                 185                 190         


Ser Pro Asp Gln Xaa Ile Phe Ile Tyr Val Gly Thr Glu Glu Ala Asp 
        195                 200                 205             


Asp Thr Asp Lys Thr Leu Met Asp Gly Asn Ile Lys Gln Ala Tyr Ile 
    210                 215                 220                 


Asp Ser Ser Leu Cys Tyr Tyr His Asp Leu Ile Ala Gly Xaa Val His 
225                 230                 235                 240 


Leu Asp Asn Leu Val Leu Lys Val Gln Ser Gly Ala Ile His Ser Glu 
                245                 250                 255     


Ile Pro Trp Ser Glu Asn Leu Pro Asp Cys Leu Arg Phe Phe Ala Glu 
            260                 265                 270         


Lys Trp 
        


<210>  22
<211>  130
<212>  PRT
<213>  Streptococcus pneumoniae


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Met or Ile

<220>
<221>  MOD_RES
<222>  (55)..(55)
<223>  Asn or Tyr

<220>
<221>  MOD_RES
<222>  (63)..(63)
<223>  His or Tyr

<220>
<221>  MOD_RES
<222>  (79)..(79)
<223>  Arg or His

<220>
<221>  MOD_RES
<222>  (97)..(97)
<223>  Ala or Glu

<220>
<221>  MOD_RES
<222>  (108)..(108)
<223>  Gly or Glu

<400>  22

Xaa Asn Gln Ser Tyr Phe Tyr Leu Lys Met Lys Glu His Lys Leu Lys 
1               5                   10                  15      


Val Pro Tyr Thr Gly Lys Glu Arg Arg Val Arg Ile Leu Leu Pro Lys 
            20                  25                  30          


Asp Tyr Glu Lys Asp Thr Asp Arg Ser Tyr Pro Val Val Tyr Phe His 
        35                  40                  45              


Asp Gly Gln Asn Val Phe Xaa Ser Lys Glu Ser Phe Ile Gly Xaa Ser 
    50                  55                  60                  


Trp Lys Ile Ile Pro Ala Ile Lys Arg Asn Pro Asp Ile Ser Xaa Met 
65                  70                  75                  80  


Ile Val Val Ala Ile Asp Asn Asp Gly Met Gly Arg Met Asn Glu Tyr 
                85                  90                  95      


Xaa Ala Trp Lys Phe Gln Glu Ser Pro Ile Pro Xaa Gln Gln Phe Gly 
            100                 105                 110         


Gly Lys Gly Val Glu Tyr Ala Glu Phe Val Met Glu Val Val Lys Pro 
        115                 120                 125             


Phe Ile 
    130 


<210>  23
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP0882 consensus with exogenous signal sequence


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Met or Thr

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Ala or Thr

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Ala or Val

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Met or Ile

<220>
<221>  MOD_RES
<222>  (80)..(80)
<223>  Asn or Tyr

<220>
<221>  MOD_RES
<222>  (88)..(88)
<223>  His or Tyr

<220>
<221>  MOD_RES
<222>  (104)..(104)
<223>  Arg or His

<220>
<221>  MOD_RES
<222>  (122)..(122)
<223>  Ala or Glu

<220>
<221>  MOD_RES
<222>  (133)..(133)
<223>  Gly or Glu

<220>
<221>  MOD_RES
<222>  (189)..(189)
<223>  Asp or Glu

<220>
<221>  MOD_RES
<222>  (190)..(190)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (212)..(212)
<223>  Phe or Ile

<220>
<221>  MOD_RES
<222>  (222)..(222)
<223>  Arg or His

<220>
<221>  MOD_RES
<222>  (263)..(263)
<223>  Gly or Arg

<400>  23

Met Ser Ser Lys Phe Xaa Lys Ser Xaa Ala Val Leu Gly Thr Xaa Thr 
1               5                   10                  15      


Leu Ala Ser Leu Leu Leu Val Ala Cys Xaa Asn Gln Ser Tyr Phe Tyr 
            20                  25                  30          


Leu Lys Met Lys Glu His Lys Leu Lys Val Pro Tyr Thr Gly Lys Glu 
        35                  40                  45              


Arg Arg Val Arg Ile Leu Leu Pro Lys Asp Tyr Glu Lys Asp Thr Asp 
    50                  55                  60                  


Arg Ser Tyr Pro Val Val Tyr Phe His Asp Gly Gln Asn Val Phe Xaa 
65                  70                  75                  80  


Ser Lys Glu Ser Phe Ile Gly Xaa Ser Trp Lys Ile Ile Pro Ala Ile 
                85                  90                  95      


Lys Arg Asn Pro Asp Ile Ser Xaa Met Ile Val Val Ala Ile Asp Asn 
            100                 105                 110         


Asp Gly Met Gly Arg Met Asn Glu Tyr Xaa Ala Trp Lys Phe Gln Glu 
        115                 120                 125             


Ser Pro Ile Pro Xaa Gln Gln Phe Gly Gly Lys Gly Val Glu Tyr Ala 
    130                 135                 140                 


Glu Phe Val Met Glu Val Val Lys Pro Phe Ile Asp Glu Thr Tyr Arg 
145                 150                 155                 160 


Thr Lys Ala Asp Cys Gln His Thr Ala Met Ile Gly Ser Ser Leu Gly 
                165                 170                 175     


Gly Asn Ile Thr Gln Phe Ile Gly Leu Glu Tyr Gln Xaa Xaa Ile Gly 
            180                 185                 190         


Cys Leu Gly Val Phe Ser Ser Ala Asn Trp Leu His Gln Glu Ala Phe 
        195                 200                 205             


Asn Arg Tyr Xaa Glu Cys Gln Lys Leu Ser Pro Asp Gln Xaa Ile Phe 
    210                 215                 220                 


Ile Tyr Val Gly Thr Glu Glu Ala Asp Asp Thr Asp Lys Thr Leu Met 
225                 230                 235                 240 


Asp Gly Asn Ile Lys Gln Ala Tyr Ile Asp Ser Ser Leu Cys Tyr Tyr 
                245                 250                 255     


His Asp Leu Ile Ala Gly Xaa Val His Leu Asp Asn Leu Val Leu Lys 
            260                 265                 270         


Val Gln Ser Gly Ala Ile His Ser Glu Ile Pro Trp Ser Glu Asn Leu 
        275                 280                 285             


Pro Asp Cys Leu Arg Phe Phe Ala Glu Lys Trp 
    290                 295                 


<210>  24
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP0882N consensus with exogenous signal sequence


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Met or Thr

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Ala or Thr

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Ala or Val

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Met or Ile

<220>
<221>  MOD_RES
<222>  (80)..(80)
<223>  Asn or Tyr

<220>
<221>  MOD_RES
<222>  (88)..(88)
<223>  His or Tyr

<220>
<221>  MOD_RES
<222>  (104)..(104)
<223>  Arg or His

<220>
<221>  MOD_RES
<222>  (122)..(122)
<223>  Ala or Glu

<220>
<221>  MOD_RES
<222>  (133)..(133)
<223>  Gly or Glu

<400>  24

Met Ser Ser Lys Phe Xaa Lys Ser Xaa Ala Val Leu Gly Thr Xaa Thr 
1               5                   10                  15      


Leu Ala Ser Leu Leu Leu Val Ala Cys Xaa Asn Gln Ser Tyr Phe Tyr 
            20                  25                  30          


Leu Lys Met Lys Glu His Lys Leu Lys Val Pro Tyr Thr Gly Lys Glu 
        35                  40                  45              


Arg Arg Val Arg Ile Leu Leu Pro Lys Asp Tyr Glu Lys Asp Thr Asp 
    50                  55                  60                  


Arg Ser Tyr Pro Val Val Tyr Phe His Asp Gly Gln Asn Val Phe Xaa 
65                  70                  75                  80  


Ser Lys Glu Ser Phe Ile Gly Xaa Ser Trp Lys Ile Ile Pro Ala Ile 
                85                  90                  95      


Lys Arg Asn Pro Asp Ile Ser Xaa Met Ile Val Val Ala Ile Asp Asn 
            100                 105                 110         


Asp Gly Met Gly Arg Met Asn Glu Tyr Xaa Ala Trp Lys Phe Gln Glu 
        115                 120                 125             


Ser Pro Ile Pro Xaa Gln Gln Phe Gly Gly Lys Gly Val Glu Tyr Ala 
    130                 135                 140                 


Glu Phe Val Met Glu Val Val Lys Pro Phe Ile 
145                 150                 155 


<210>  25
<211>  357
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  25

Met Ala Asn Ile Phe Asp Tyr Leu Lys Asp Val Ala Tyr Asp Ser Tyr 
1               5                   10                  15      


Tyr Asp Leu Pro Leu Asn Glu Leu Asp Ile Leu Thr Leu Ile Glu Ile 
            20                  25                  30          


Thr Tyr Leu Ser Phe Asp Asn Leu Val Ser Thr Leu Pro Gln Arg Leu 
        35                  40                  45              


Leu Asp Leu Ala Pro Gln Val Pro Arg Asp Pro Thr Met Leu Thr Ser 
    50                  55                  60                  


Lys Asn Arg Leu Gln Leu Leu Asp Glu Leu Ala Gln His Lys Arg Phe 
65                  70                  75                  80  


Lys Asn Cys Lys Leu Ser His Phe Ile Asn Asp Ile Asp Pro Glu Leu 
                85                  90                  95      


Gln Lys Gln Phe Ala Ala Met Thr Tyr Arg Val Ser Leu Asp Thr Tyr 
            100                 105                 110         


Leu Ile Val Phe Arg Gly Thr Asp Asp Ser Ile Ile Gly Trp Lys Glu 
        115                 120                 125             


Asp Phe His Leu Thr Tyr Met Lys Glu Ile Pro Ala Gln Lys His Ala 
    130                 135                 140                 


Leu Arg Tyr Leu Lys Asn Phe Phe Ala His His Pro Lys Gln Lys Val 
145                 150                 155                 160 


Ile Leu Ala Gly His Ser Lys Gly Gly Asn Leu Ala Ile Tyr Ala Ala 
                165                 170                 175     


Ser Gln Ile Glu Gln Ser Leu Gln Asn Gln Ile Thr Ala Val Tyr Thr 
            180                 185                 190         


Phe Asp Ala Pro Gly Leu His Gln Glu Leu Thr Gln Thr Ala Gly Tyr 
        195                 200                 205             


Gln Arg Ile Met Asp Arg Ser Lys Ile Phe Ile Pro Gln Gly Ser Ile 
    210                 215                 220                 


Ile Gly Met Met Leu Glu Ile Pro Ala His Gln Ile Ile Val Gln Ser 
225                 230                 235                 240 


Thr Ala Leu Gly Gly Ile Ala Gln His Asp Thr Phe Ser Trp Gln Ile 
                245                 250                 255     


Glu Asp Lys His Phe Val Gln Leu Asp Lys Thr Asn Ser Asp Ser Gln 
            260                 265                 270         


Gln Val Asp Thr Thr Phe Lys Glu Trp Val Ala Thr Val Pro Asp Glu 
        275                 280                 285             


Glu Leu Gln Leu Tyr Phe Asp Leu Phe Phe Gly Thr Ile Leu Asp Ala 
    290                 295                 300                 


Gly Ile Ser Ser Ile Asn Asp Leu Ala Ser Leu Lys Ala Leu Glu Tyr 
305                 310                 315                 320 


Ile His His Leu Phe Val Gln Ala Gln Ser Leu Thr Pro Glu Glu Arg 
                325                 330                 335     


Glu Thr Leu Gly Arg Leu Thr Gln Leu Leu Ile Asp Thr Arg Tyr Gln 
            340                 345                 350         


Ala Trp Lys Asn Arg 
        355         


<210>  26
<211>  1066
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  26

Met Gln Thr Lys Thr Lys Lys Leu Ile Val Ser Leu Ser Ser Leu Val 
1               5                   10                  15      


Leu Ser Gly Phe Leu Leu Asn His Tyr Met Thr Ile Gly Ala Glu Glu 
            20                  25                  30          


Thr Thr Thr Asn Thr Ile Gln Gln Ser Gln Lys Glu Val Gln Tyr Gln 
        35                  40                  45              


Gln Arg Asp Thr Lys Asn Leu Val Glu Asn Gly Asp Phe Gly Gln Thr 
    50                  55                  60                  


Glu Asp Gly Ser Ser Pro Trp Thr Gly Ser Lys Ala Gln Gly Trp Ser 
65                  70                  75                  80  


Ala Trp Val Asp Gln Lys Asn Ser Ala Asp Ala Ser Thr Arg Val Ile 
                85                  90                  95      


Glu Ala Lys Asp Gly Ala Ile Thr Ile Ser Ser His Glu Lys Leu Arg 
            100                 105                 110         


Ala Ala Leu His Arg Met Val Pro Ile Glu Ala Lys Lys Lys Tyr Lys 
        115                 120                 125             


Leu Arg Phe Lys Ile Lys Thr Asp Asn Lys Ile Gly Ile Ala Lys Val 
    130                 135                 140                 


Arg Ile Ile Glu Glu Ser Gly Lys Asp Lys Arg Leu Trp Asn Ser Ala 
145                 150                 155                 160 


Thr Thr Ser Gly Thr Lys Asp Trp Gln Thr Ile Glu Ala Asp Tyr Ser 
                165                 170                 175     


Pro Thr Leu Asp Val Asp Lys Ile Lys Leu Glu Leu Phe Tyr Glu Thr 
            180                 185                 190         


Gly Thr Gly Thr Val Ser Phe Lys Asp Ile Glu Leu Val Glu Val Ala 
        195                 200                 205             


Asp Gln Leu Ser Glu Asp Ser Gln Thr Asp Lys Gln Leu Glu Glu Lys 
    210                 215                 220                 


Ile Asp Leu Pro Ile Gly Lys Lys His Val Phe Ser Leu Ala Asp Tyr 
225                 230                 235                 240 


Thr Tyr Lys Val Glu Asn Pro Asp Val Ala Ser Val Lys Asn Gly Ile 
                245                 250                 255     


Leu Glu Pro Leu Lys Glu Gly Thr Thr Asn Val Ile Val Ser Lys Asp 
            260                 265                 270         


Gly Lys Glu Val Lys Lys Ile Pro Leu Lys Ile Leu Ala Ser Val Lys 
        275                 280                 285             


Asp Ala Tyr Thr Asp Arg Leu Asp Asp Trp Asn Gly Ile Ile Ala Gly 
    290                 295                 300                 


Asn Gln Tyr Tyr Asp Ser Lys Asn Glu Gln Met Ala Lys Leu Asn Gln 
305                 310                 315                 320 


Glu Leu Glu Gly Lys Val Ala Asp Ser Leu Ser Ser Ile Ser Ser Gln 
                325                 330                 335     


Ala Asp Arg Thr Tyr Leu Trp Glu Lys Phe Ser Asn Tyr Lys Thr Ser 
            340                 345                 350         


Ala Asn Leu Thr Ala Thr Tyr Arg Lys Leu Glu Glu Met Ala Lys Gln 
        355                 360                 365             


Val Thr Asn Pro Ser Ser Arg Tyr Tyr Gln Asp Glu Thr Val Val Arg 
    370                 375                 380                 


Thr Val Arg Asp Ser Met Glu Trp Met His Lys His Val Tyr Asn Ser 
385                 390                 395                 400 


Glu Lys Ser Ile Val Gly Asn Trp Trp Asp Tyr Glu Ile Gly Thr Pro 
                405                 410                 415     


Arg Ala Ile Asn Asn Thr Leu Ser Leu Met Lys Glu Tyr Phe Ser Asp 
            420                 425                 430         


Glu Glu Ile Lys Lys Tyr Thr Asp Val Ile Glu Lys Phe Val Pro Asp 
        435                 440                 445             


Pro Glu His Phe Arg Lys Thr Thr Asp Asn Pro Phe Lys Ala Leu Gly 
    450                 455                 460                 


Gly Asn Leu Val Asp Met Gly Arg Val Lys Val Ile Ala Gly Leu Leu 
465                 470                 475                 480 


Arg Lys Asp Asp Gln Glu Ile Ser Ser Thr Ile Arg Ser Ile Glu Gln 
                485                 490                 495     


Val Phe Lys Leu Val Asp Gln Gly Glu Gly Phe Tyr Gln Asp Gly Ser 
            500                 505                 510         


Tyr Ile Asp His Thr Asn Val Ala Tyr Thr Gly Ala Tyr Gly Asn Val 
        515                 520                 525             


Leu Ile Asp Gly Leu Ser Gln Leu Leu Pro Val Ile Gln Lys Thr Lys 
    530                 535                 540                 


Asn Pro Ile Asp Lys Asp Lys Met Gln Thr Met Tyr His Trp Ile Asp 
545                 550                 555                 560 


Lys Ser Phe Ala Pro Leu Leu Val Asn Gly Glu Leu Met Asp Met Ser 
                565                 570                 575     


Arg Gly Arg Ser Ile Ser Arg Ala Asn Ser Glu Gly His Val Ala Ala 
            580                 585                 590         


Val Glu Val Leu Arg Gly Ile His Arg Ile Ala Asp Met Ser Glu Gly 
        595                 600                 605             


Glu Thr Lys Gln Cys Leu Gln Ser Leu Val Lys Thr Ile Val Gln Ser 
    610                 615                 620                 


Asp Ser Tyr Tyr Asp Val Phe Lys Asn Leu Lys Thr Tyr Lys Asp Ile 
625                 630                 635                 640 


Ser Leu Met Gln Ser Leu Leu Ser Asp Ala Gly Val Ala Ser Val Pro 
                645                 650                 655     


Arg Pro Ser Tyr Leu Ser Ala Phe Asn Lys Met Asp Lys Thr Ala Met 
            660                 665                 670         


Tyr Asn Ala Glu Lys Gly Phe Gly Phe Gly Leu Ser Leu Phe Ser Ser 
        675                 680                 685             


Arg Thr Leu Asn Tyr Glu His Met Asn Lys Glu Asn Lys Arg Gly Trp 
    690                 695                 700                 


Tyr Thr Ser Asp Gly Met Phe Tyr Leu Tyr Asn Gly Asp Leu Ser His 
705                 710                 715                 720 


Tyr Ser Asp Gly Tyr Trp Pro Thr Val Asn Pro Tyr Lys Met Pro Gly 
                725                 730                 735     


Thr Thr Glu Thr Asp Ala Lys Arg Ala Asp Ser Asp Thr Gly Lys Val 
            740                 745                 750         


Leu Pro Ser Ala Phe Val Gly Thr Ser Lys Leu Asp Asp Ala Asn Ala 
        755                 760                 765             


Thr Ala Thr Met Asp Phe Thr Asn Trp Asn Gln Thr Leu Thr Ala His 
    770                 775                 780                 


Lys Ser Trp Phe Met Leu Lys Asp Lys Ile Ala Phe Leu Gly Ser Asn 
785                 790                 795                 800 


Ile Gln Asn Thr Ser Thr Asp Thr Ala Ala Thr Thr Ile Asp Gln Arg 
                805                 810                 815     


Lys Leu Glu Ser Gly Asn Pro Tyr Lys Val Tyr Val Asn Asp Lys Glu 
            820                 825                 830         


Ala Ser Leu Thr Glu Gln Glu Lys Asp Tyr Pro Glu Thr Gln Ser Val 
        835                 840                 845             


Phe Leu Glu Ser Phe Asp Ser Lys Lys Asn Ile Gly Tyr Phe Phe Phe 
    850                 855                 860                 


Lys Lys Ser Ser Ile Ser Met Ser Lys Ala Leu Gln Lys Gly Ala Trp 
865                 870                 875                 880 


Lys Asp Ile Asn Glu Gly Gln Ser Asp Lys Glu Val Glu Asn Glu Phe 
                885                 890                 895     


Leu Thr Ile Ser Gln Ala His Lys Gln Asn Arg Asp Ser Tyr Gly Tyr 
            900                 905                 910         


Met Leu Ile Pro Asn Val Asp Arg Ala Thr Phe Asn Gln Met Ile Lys 
        915                 920                 925             


Glu Leu Glu Ser Ser Leu Ile Glu Asn Asn Glu Thr Leu Gln Ser Val 
    930                 935                 940                 


Tyr Asp Ala Lys Gln Gly Val Trp Gly Ile Val Lys Tyr Asp Asp Ser 
945                 950                 955                 960 


Val Ser Thr Ile Ser Asn Gln Phe Gln Val Leu Lys Arg Gly Val Tyr 
                965                 970                 975     


Thr Ile Arg Lys Glu Gly Asp Glu Tyr Lys Ile Ala Tyr Tyr Asn Pro 
            980                 985                 990         


Glu Thr Gln Glu Ser Ala Pro Asp  Gln Glu Val Phe Lys  Lys Leu Glu 
        995                 1000                 1005             


Gln Ala  Ala Gln Pro Gln Val  Gln Asn Ser Lys Glu  Lys Glu Lys 
    1010                 1015                 1020             


Ser Glu  Glu Glu Lys Asn His  Ser Asp Gln Lys Asn  Leu Pro Gln 
    1025                 1030                 1035             


Thr Gly  Glu Gly Gln Ser Ile  Leu Ala Ser Leu Gly  Phe Leu Leu 
    1040                 1045                 1050             


Leu Gly  Ala Phe Tyr Leu Phe  Arg Arg Gly Lys Asn  Asn 
    1055                 1060                 1065     


<210>  27
<211>  653
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  27

Met Asn Lys Lys Lys Met Ile Leu Thr Ser Leu Ala Ser Val Ala Ile 
1               5                   10                  15      


Leu Gly Ala Gly Phe Val Ala Ser Ser Pro Thr Phe Val Arg Ala Glu 
            20                  25                  30          


Glu Ala Pro Val Ala Asn Gln Ser Lys Ala Glu Lys Asp Tyr Asp Ala 
        35                  40                  45              


Ala Val Lys Lys Ser Glu Ala Ala Lys Lys Asp Tyr Glu Thr Ala Lys 
    50                  55                  60                  


Lys Lys Ala Glu Asp Ala Gln Lys Lys Tyr Asp Glu Asp Gln Lys Lys 
65                  70                  75                  80  


Thr Glu Ala Lys Ala Glu Lys Glu Arg Lys Ala Ser Glu Lys Ile Ala 
                85                  90                  95      


Glu Ala Thr Lys Glu Val Gln Gln Ala Tyr Leu Ala Tyr Leu Gln Ala 
            100                 105                 110         


Ser Asn Glu Ser Gln Arg Lys Glu Ala Asp Lys Lys Ile Lys Glu Ala 
        115                 120                 125             


Thr Gln Arg Lys Asp Glu Ala Glu Ala Ala Phe Ala Thr Ile Arg Thr 
    130                 135                 140                 


Thr Ile Val Val Pro Glu Pro Ser Glu Leu Ala Glu Thr Lys Lys Lys 
145                 150                 155                 160 


Ala Glu Glu Ala Thr Lys Glu Ala Glu Val Ala Lys Lys Lys Ser Glu 
                165                 170                 175     


Glu Ala Ala Lys Glu Val Glu Val Glu Lys Asn Lys Ile Leu Glu Gln 
            180                 185                 190         


Asp Ala Glu Asn Glu Lys Lys Ile Asp Val Leu Gln Asn Lys Val Ala 
        195                 200                 205             


Asp Leu Glu Lys Gly Ile Ala Pro Tyr Gln Asn Glu Val Ala Glu Leu 
    210                 215                 220                 


Asn Lys Glu Ile Ala Arg Leu Gln Ser Asp Leu Lys Asp Ala Glu Glu 
225                 230                 235                 240 


Asn Asn Val Glu Asp Tyr Ile Lys Glu Gly Leu Glu Gln Ala Ile Thr 
                245                 250                 255     


Asn Lys Lys Ala Glu Leu Ala Thr Thr Gln Gln Asn Ile Asp Lys Thr 
            260                 265                 270         


Gln Lys Asp Leu Glu Asp Ala Glu Leu Glu Leu Glu Lys Val Leu Ala 
        275                 280                 285             


Thr Leu Asp Pro Glu Gly Lys Thr Gln Asp Glu Leu Asp Lys Glu Ala 
    290                 295                 300                 


Ala Glu Ala Glu Leu Asn Glu Lys Val Glu Ala Leu Gln Asn Gln Val 
305                 310                 315                 320 


Ala Glu Leu Glu Glu Glu Leu Ser Lys Leu Glu Asp Asn Leu Lys Asp 
                325                 330                 335     


Ala Glu Thr Asn Asn Val Glu Asp Tyr Ile Lys Glu Gly Leu Glu Glu 
            340                 345                 350         


Ala Ile Ala Thr Lys Lys Ala Glu Leu Glu Lys Thr Gln Lys Glu Leu 
        355                 360                 365             


Asp Ala Ala Leu Asn Glu Leu Gly Pro Asp Gly Asp Glu Glu Glu Thr 
    370                 375                 380                 


Pro Ala Pro Ala Pro Gln Pro Glu Lys Pro Ala Glu Glu Pro Glu Asn 
385                 390                 395                 400 


Pro Ala Pro Ala Pro Lys Pro Glu Lys Ser Ala Asp Gln Gln Ala Glu 
                405                 410                 415     


Glu Asp Tyr Ala Arg Arg Ser Glu Glu Glu Tyr Asn Arg Leu Thr Gln 
            420                 425                 430         


Gln Gln Pro Pro Lys Ala Glu Lys Pro Ala Pro Ala Pro Gln Pro Glu 
        435                 440                 445             


Gln Pro Ala Pro Ala Pro Lys Ile Gly Trp Lys Gln Glu Asn Gly Met 
    450                 455                 460                 


Trp Tyr Phe Tyr Asn Thr Asp Gly Ser Met Ala Thr Gly Trp Leu Gln 
465                 470                 475                 480 


Asn Asn Gly Ser Trp Tyr Tyr Leu Asn Ser Asn Gly Ala Met Ala Thr 
                485                 490                 495     


Gly Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly 
            500                 505                 510         


Ala Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu 
        515                 520                 525             


Asn Ala Asn Gly Ala Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser 
    530                 535                 540                 


Trp Tyr Tyr Leu Asn Ala Asn Gly Asp Met Ala Thr Gly Trp Leu Gln 
545                 550                 555                 560 


Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Asp Met Ala Thr 
                565                 570                 575     


Gly Trp Ala Lys Val His Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly 
            580                 585                 590         


Ser Met Ala Thr Gly Trp Val Lys Asp Gly Glu Thr Trp Tyr Tyr Leu 
        595                 600                 605             


Glu Ala Ser Gly Ser Met Lys Ala Asn Gln Trp Phe Gln Val Ser Asp 
    610                 615                 620                 


Lys Trp Tyr Tyr Val Asn Gly Leu Gly Ser Leu Ser Val Asn Thr Thr 
625                 630                 635                 640 


Val Asp Gly Tyr Lys Val Asn Ala Asn Gly Glu Trp Val 
                645                 650             


<210>  28
<211>  283
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  28

Met Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
1               5                   10                  15      


Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
            20                  25                  30          


Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
        35                  40                  45              


Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
    50                  55                  60                  


Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
65                  70                  75                  80  


Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
                85                  90                  95      


Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly 
            100                 105                 110         


Ser Gly His Met His His His His His His Ser Ser Gly Leu Val Pro 
        115                 120                 125             


Arg Gly Ser Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln 
    130                 135                 140                 


His Met Asp Ser Pro Asp Leu Gly Thr Asp Asp Asp Asp Lys Ala Met 
145                 150                 155                 160 


Ala Asp Leu Lys Lys Ala Val Asn Glu Pro Glu Lys Pro Ala Glu Glu 
                165                 170                 175     


Pro Glu Asn Pro Ala Pro Ala Pro Lys Pro Ala Pro Ala Pro Gln Pro 
            180                 185                 190         


Glu Lys Pro Ala Pro Ala Pro Ala Pro Lys Pro Glu Lys Ser Ala Asp 
        195                 200                 205             


Gln Gln Ala Glu Glu Asp Tyr Ala Arg Arg Ser Glu Glu Glu Tyr Asn 
    210                 215                 220                 


Arg Leu Thr Gln Gln Gln Pro Pro Lys Ala Glu Lys Pro Ala Pro Ala 
225                 230                 235                 240 


Pro Val Pro Lys Pro Glu Gln Pro Ala Pro Ala Pro Lys Thr Gly Trp 
                245                 250                 255     


Gly Gln Glu Asn Gly Met Trp Cys Arg Gln Ala Cys Gly Arg Thr Arg 
            260                 265                 270         


Ala Pro Pro Pro Pro Pro Leu Arg Ser Gly Cys 
        275                 280             


<210>  29
<211>  103
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  29

Ala Asp Leu Lys Lys Ala Val Asn Glu Pro Glu Lys Pro Ala Glu Glu 
1               5                   10                  15      


Pro Glu Asn Pro Ala Pro Ala Pro Lys Pro Ala Pro Ala Pro Gln Pro 
            20                  25                  30          


Glu Lys Pro Ala Pro Ala Pro Ala Pro Lys Pro Glu Lys Ser Ala Asp 
        35                  40                  45              


Gln Gln Ala Glu Glu Asp Tyr Ala Arg Arg Ser Glu Glu Glu Tyr Asn 
    50                  55                  60                  


Arg Leu Thr Gln Gln Gln Pro Pro Lys Ala Glu Lys Pro Ala Pro Ala 
65                  70                  75                  80  


Pro Val Pro Lys Pro Glu Gln Pro Ala Pro Ala Pro Lys Thr Gly Trp 
                85                  90                  95      


Gly Gln Glu Asn Gly Met Trp 
            100             


<210>  30
<211>  58
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  30

Met Ala Lys Lys Ala Glu Leu Glu Lys Thr Pro Glu Lys Pro Ala Glu 
1               5                   10                  15      


Glu Pro Glu Asn Pro Ala Pro Ala Pro Gln Pro Glu Lys Ser Ala Asp 
            20                  25                  30          


Gln Gln Ala Glu Glu Asp Tyr Ala Arg Arg Ser Glu Glu Glu Tyr Asn 
        35                  40                  45              


Arg Leu Thr Gln Gln Gln Pro Pro Lys Ala 
    50                  55              


<210>  31
<211>  286
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  31

Met Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
1               5                   10                  15      


Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
            20                  25                  30          


Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
        35                  40                  45              


Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
    50                  55                  60                  


Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
65                  70                  75                  80  


Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
                85                  90                  95      


Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly 
            100                 105                 110         


Ser Gly His Met His His His His His His Ser Ser Gly Leu Val Pro 
        115                 120                 125             


Arg Gly Ser Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln 
    130                 135                 140                 


His Met Asp Ser Pro Asp Leu Gly Thr Asp Asp Asp Asp Lys Ala Met 
145                 150                 155                 160 


Ala Asp Leu Lys Lys Ala Val Asn Glu Pro Glu Thr Pro Ala Pro Ala 
                165                 170                 175     


Pro Ala Pro Ala Pro Ala Pro Ala Pro Thr Pro Glu Ala Pro Ala Pro 
            180                 185                 190         


Ala Pro Ala Pro Ala Pro Lys Pro Ala Pro Ala Pro Lys Pro Ala Pro 
        195                 200                 205             


Ala Pro Lys Pro Ala Pro Ala Pro Lys Pro Ala Pro Ala Pro Lys Pro 
    210                 215                 220                 


Ala Pro Ala Pro Lys Pro Ala Pro Ala Pro Ala Pro Ala Pro Lys Pro 
225                 230                 235                 240 


Glu Lys Pro Ala Glu Lys Pro Ala Pro Ala Pro Lys Pro Glu Thr Pro 
                245                 250                 255     


Lys Thr Gly Trp Lys Gln Glu Asn Gly Met Trp Cys Arg Gln Ala Cys 
            260                 265                 270         


Gly Arg Thr Arg Ala Pro Pro Pro Pro Pro Leu Arg Ser Gly 
        275                 280                 285     


<210>  32
<211>  106
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  32

Asp Leu Lys Lys Ala Val Asn Glu Pro Glu Thr Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro Ala Pro Ala Pro Thr Pro Glu Ala Pro Ala Pro Ala 
            20                  25                  30          


Pro Ala Pro Ala Pro Lys Pro Ala Pro Ala Pro Lys Pro Ala Pro Ala 
        35                  40                  45              


Pro Lys Pro Ala Pro Ala Pro Lys Pro Ala Pro Ala Pro Lys Pro Ala 
    50                  55                  60                  


Pro Ala Pro Lys Pro Ala Pro Ala Pro Ala Pro Ala Pro Lys Pro Glu 
65                  70                  75                  80  


Lys Pro Ala Glu Lys Pro Ala Pro Ala Pro Lys Pro Glu Thr Pro Lys 
                85                  90                  95      


Thr Gly Trp Lys Gln Glu Asn Gly Met Trp 
            100                 105     


<210>  33
<211>  121
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  33

Tyr Phe Lys Glu Gly Leu Glu Lys Thr Ile Ala Ala Lys Lys Ala Glu 
1               5                   10                  15      


Leu Glu Lys Thr Glu Ala Asp Leu Lys Lys Ala Val Asn Glu Pro Glu 
            20                  25                  30          


Lys Pro Ala Pro Ala Pro Glu Thr Pro Ala Pro Glu Ala Pro Ala Glu 
        35                  40                  45              


Gln Pro Lys Pro Ala Pro Ala Pro Gln Pro Ala Pro Ala Pro Lys Pro 
    50                  55                  60                  


Glu Lys Pro Ala Glu Gln Pro Lys Pro Glu Lys Thr Asp Asp Gln Gln 
65                  70                  75                  80  


Ala Glu Glu Asp Tyr Ala Arg Arg Ser Glu Glu Glu Tyr Asn Arg Leu 
                85                  90                  95      


Thr Gln Gln Gln Pro Pro Lys Ala Glu Lys Pro Ala Pro Ala Pro Lys 
            100                 105                 110         


Thr Gly Trp Lys Gln Glu Asn Gly Met 
        115                 120     


<210>  34
<211>  27
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  34

Glu Lys Ser Ala Asp Gln Gln Ala Glu Glu Asp Tyr Ala Arg Arg Ser 
1               5                   10                  15      


Glu Glu Glu Tyr Asn Arg Leu Thr Gln Gln Gln 
            20                  25          


<210>  35
<211>  23
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  35

Asp Gln Gln Ala Glu Glu Asp Tyr Ala Arg Arg Ser Glu Glu Glu Tyr 
1               5                   10                  15      


Asn Arg Leu Thr Gln Gln Gln 
            20              


<210>  36
<211>  28
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  36

Met Glu Lys Ser Ala Asp Gln Gln Ala Glu Glu Asp Tyr Ala Arg Arg 
1               5                   10                  15      


Ser Glu Glu Glu Tyr Asn Arg Leu Thr Gln Gln Gln 
            20                  25              


<210>  37
<211>  768
<212>  DNA
<213>  Streptococcus pneumoniae

<400>  37
atgtgctcag ggggtgctaa gaaagaagga gaagcagcta gcaagaaaga aatcatcgtt       60

gcaaccaatg gatcaccaaa gccatttatc tatgaagaaa atggcgaatt gactggttac      120

gagattgaag tcgttcgcgc tatctttaaa gattctgaca aatatgatgt caagtttgaa      180

aagacagaat ggtcaggtgt ctttgctggt cttgacgctg atcgttacaa tatggctgtc      240

aacaatctta gctacactaa agaacgtgcg gagaaatacc tctatgccgc accaattgcc      300

caaaatccta atgtccttgt cgtgaagaaa gatgactcta gtatcaagtc tctcgatgat      360

atcggtggaa aatcgacgga agtcgttcaa gccactacat cagctaagca gttagaagca      420

tacaatgctg aacacacgga caacccaact atccttaact atactaaggc agacttccaa      480

caaatcatgg tacgtttgag cgatggacaa tttgactata agatttttga taaaatcggt      540

gttgaaacag tgatcaagaa ccaaggtttg gacaacttga aagttatcga acttccaagc      600

gaccaacaac cgtacgttta cccacttctt gctcagggtc aagatgagtt gaaatcgttt      660

gtagacaaac gcatcaaaga actttataaa gatggaactc ttgaaaaatt gtctaaacaa      720

ttcttcggag acacttatct accggcagaa gctgatatta aagagtaa                   768


<210>  38
<211>  834
<212>  DNA
<213>  Streptococcus pneumoniae

<400>  38
atgaaaaaaa tcgttaaata ctcatctctt gcagcccttg ctcttgttgc tgcaggtgtg       60

cttgcggctt gctcaggggg tgctaagaaa gaaggagaag cagctagcaa gaaagaaatc      120

atcgttgcaa ccaatggatc accaaagcca tttatctatg aagaaaatgg cgaattgact      180

ggttacgaga ttgaagtcgt tcgcgctatc tttaaagatt ctgacaaata tgatgtcaag      240

tttgaaaaga cagaatggtc aggtgtcttt gctggtcttg acgctgatcg ttacaatatg      300

gctgtcaaca atcttagcta cactaaagaa cgtgcggaga aatacctcta tgccgcacca      360

attgcccaaa atcctaatgt ccttgtcgtg aagaaagatg actctagtat caagtctctc      420

gatgatatcg gtggaaaatc gacggaagtc gttcaagcca ctacatcagc taagcagtta      480

gaagcataca atgctgaaca cacggacaac ccaactatcc ttaactatac taaggcagac      540

ttccaacaaa tcatggtacg tttgagcgat ggacaatttg actataagat ttttgataaa      600

atcggtgttg aaacagtgat caagaaccaa ggtttggaca acttgaaagt tatcgaactt      660

ccaagcgacc aacaaccgta cgtttaccca cttcttgctc agggtcaaga tgagttgaaa      720

tcgtttgtag acaaacgcat caaagaactt tataaagatg gaactcttga aaaattgtct      780

aaacaattct tcggagacac ttatctaccg gcagaagctg atattaaaga gtaa            834


<210>  39
<211>  1203
<212>  DNA
<213>  Streptococcus pneumoniae

<400>  39
atgtgcggaa gcaaaactgc tgataagcct gctgattctg gttcatctga agtcaaagaa       60

ctcactgtat atgtagacga gggatataag agctatattg aagaggttgc taaagcttat      120

gaaaaagaag ctggagtaaa agtcactctt aaaactggtg atgctctagg aggtcttgat      180

aaactttctc ttgacaacca atctggtaat gtccctgatg ttatgatggc tccatacgac      240

cgtgtaggta gccttggttc tgacggacaa ctttcagaag tgaaattgag cgatggtgct      300

aaaacagacg acacaactaa atctcttgta acagctgcta atggtaaagt ttacggtgct      360

cctgccgtta tcgagtcact tgttatgtac tacaacaaag acttggtgaa agatgctcca      420

aaaacatttg ctgacttgga aaaccttgct aaagatagca aatacgcatt cgctggtgaa      480

gatggtaaaa ctactgcctt cctagctgac tggacaaact tctactatac atatggactt      540

cttgccggta acggtgctta cgtctttggc caaaacggta aagacgctaa agacatcggt      600

cttgcaaacg acggttctat cgtaggtatc aactacgcta aatcttggta cgaaaaatgg      660

cctaaaggta tgcaagatac agaaggtgct ggaaacttaa tccaaactca attccaagaa      720

ggtaaaacag ctgctatcat cgacggacct tggaaagctc aagcctttaa agatgctaaa      780

gtaaactacg gagttgcaac tatcccaact cttccaaatg gaaaagaata tgctgcattc      840

ggtggtggta aagcttgggt cattcctcaa gccgttaaga accttgaagc ttctcaaaaa      900

tttgtagact tccttgttgc aactgaacaa caaaaagtat tatatgataa gactaacgaa      960

atcccagcta atactgaggc tcgttcatac gctgaaggta aaaacgatga gttgacaaca     1020

gctgttatca aacagttcaa gaacactcaa ccactgccaa acatctctca aatgtctgca     1080

gtttgggatc cagcgaaaaa tatgctcttt gatgctgtaa gtggtcaaaa agatgctaaa     1140

acagctgcta acgatgctgt aacattgatc aaagaaacaa tcaaacaaaa atttggtgaa     1200

taa                                                                   1203


<210>  40
<211>  300
<212>  DNA
<213>  Streptococcus pneumoniae

<400>  40
atgaatggta tgaaagctaa aaaaatgtgg atggcaggct tggctctgct aggtatcgga       60

agccttgctc ttgctacgaa aaaagttgca gatgaccgta agctcatgaa gactcaggaa      120

gagttgacag agattgtgcg agaccatttt tccgacatgg gggaaattgc gaccctttat      180

gttcaagttt acgaaagcag tctggagagc ttggttggtg gcgtcatttt tgaggatggc      240

cgtcattata cctttgtcta tgaaaatgaa gacctagtct atgaggagga agtcttatga      300


<210>  41
<211>  279
<212>  DNA
<213>  Streptococcus pneumoniae

<400>  41
atgagatacc tggcaacatt gttgttatct ctggcggtgt taatcaccgc cgggtgcaaa       60

aaagttgcag atgaccgtaa gctcatgaag actcaggaag agttgacaga gattgtgcga      120

gaccattttt ccgacatggg ggaaattgcg accctttatg ttcaagttta cgaaagcagt      180

ctggagagct tggttggtgg cgtcattttt gaggatggcc gtcattatac ctttgtctat      240

gaaaatgaag acctagtcta tgaggaggaa gtcttatga                             279


<210>  42
<211>  1986
<212>  DNA
<213>  Streptococcus pneumoniae

<400>  42
atggtagtct tagcagacac atctagctct gaagatgctt taaacatctc tgataaagaa       60

aaagtagcag aaaataaaga gaaacatgaa aatatccata gtgctatgga aacttcacag      120

gattttaaag agaagaaaac agcagtcatt aaggaaaaag aagttgttag taaaaatcct      180

gtgatagaca ataacactag caatgaagaa gcaaaaatca aagaagaaaa ttccaataaa      240

tcccaaggag attatacgga ctcatttgtg aataaaaaca cagaaaatcc caaaaaagaa      300

gataaagttg tctatattgc tgaatttaaa gataaagaat ctggagaaaa agcaatcaag      360

gaactatcca gtcttaagaa tacaaaagtt ttatatactt atgatagaat ttttaacggt      420

agtgccatag aaacaactcc agataacttg gacaaaatta aacaaataga aggtatttca      480

tcggttgaaa gggcacaaaa agtccaaccc atgatgaatc atgccagaaa ggaaattgga      540

gttgaggaag ctattgatta cctaaagtct atcaatgctc cgtttgggaa aaattttgat      600

ggtagaggta tggtcatttc aaatatcgat actggaacag attatagaca taaggctatg      660

agaatcgatg atgatgccaa agcctcaatg agatttaaaa aagaagactt aaaaggcact      720

gataaaaatt attggttgag tgataaaatc cctcatgcgt tcaattatta taatggtggc      780

aaaatcactg tagaaaaata tgatgatgga agggattatt ttgacccaca tgggatgcat      840

attgcaggga ttcttgctgg aaatgatact gaacaagaca tcaaaaactt taacggcata      900

gatggaattg cacctaatgc acaaattttc tcttacaaaa tgtattctga cgcaggatct      960

gggtttgcgg gtgatgaaac aatgtttcat gctattgaag attctatcaa acacaacgtt     1020

gatgttgttt cggtatcatc tggttttaca ggaacaggtc ttgtaggtga gaaatattgg     1080

caagctattc gggcattaag aaaagcaggc attccaatgg ttgtcgctac gggtaactat     1140

gcgacttctg cttcaagttc ttcatgggat ttagtagcaa ataatcatct gaaaatgacc     1200

gacactggaa atgtaacacg aactgcagca catgaagatg cgatagcggt cgcttctgct     1260

aaaaatcaaa cagttgagtt tgataaagtt aacataggtg gagaaagttt taaatacaga     1320

aatatagggg cctttttcga taagagtaaa atcacaacaa atgaagatgg aacaaaagct     1380

cctagtaaat taaaatttgt atatataggc aaggggcaag accaagattt gataggtttg     1440

gatcttaggg gcaaaattgc agtaatggat agaatttata caaaggattt aaaaaatgct     1500

tttaaaaaag ctatggataa gggtgcacgc gccattatgg ttgtaaatac tgtaaattac     1560

tacaatagag ataattggac agagcttcca gctatgggat atgaagcgga tgaaggtact     1620

aaaagtcaag tgttttcaat ttcaggagat gatggtgtaa agctatggaa catgattaat     1680

cctgataaaa aaactgaagt caaaagaaat aataaagaag attttaaaga taaattggag     1740

caatactatc caattgatat ggaaagtttt aattccaaca aaccgaatgt aggtgacgaa     1800

aaagagattg actttaagtt tgcacctgac acagacaaag aactctataa agaagatatc     1860

atcgttccag caggatctac atcttggggg ccaagaatag atttactttt aaaacccgat     1920

gtttcagcac ctggtaaaaa tattaaatcc acgcttaatg ttattaatgg caaatcaact     1980

tatggc                                                                1986


<210>  43
<211>  390
<212>  DNA
<213>  Streptococcus pneumoniae

<400>  43
atgaatcaat cctactttta tctaaaaatg aaagaacaca aactcaaggt tccttataca       60

ggtaaggagc gccgtgtacg tattcttctt cctaaagatt atgagaaaga tacagaccgt      120

tcctatcctg ttgtatactt tcatgacggg caaaatgttt ttaatagcaa agagtctttc      180

attggacatt catggaagat tatcccagct atcaaacgaa atccggatat cagtcgcatg      240

attgtcgttg ctattgacaa tgatggtatg gggcggatga atgagtatgc ggcttggaag      300

ttccaagaat ctcctatccc agggcagcag tttggtggta agggtgtgga gtatgctgag      360

tttgtcatgg aggtggtcaa gccttttatc                                       390


<210>  44
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP0882 with exogenous signal sequence

<400>  44
atgtcatcta aatttatgaa gagcgctgcg gtgcttggaa ctgctacact tgctagcttg       60

cttttggtag cttgcatgaa tcaatcctac ttttatctaa aaatgaaaga acacaaactc      120

aaggttcctt atacaggtaa ggagcgccgt gtacgtattc ttcttcctaa agattatgag      180

aaagatacag accgttccta tcctgttgta tactttcatg acgggcaaaa tgtttttaat      240

agcaaagagt ctttcattgg acattcatgg aagattatcc cagctatcaa acgaaatccg      300

gatatcagtc gcatgattgt cgttgctatt gacaatgatg gtatggggcg gatgaatgag      360

tatgcggctt ggaagttcca agaatctcct atcccagggc agcagtttgg tggtaagggt      420

gtggagtatg ctgagtttgt catggaggtg gtcaagcctt ttatcgatga gacctatcgt      480

acaaaagcag actgccagca tacggctatg attggttcct cactaggagg caatattacc      540

cagtttatcg gtttggaata ccaagaccaa attggttgct tgggcgtttt ttcatctgca      600

aactggctcc accaagaagc ctttaaccgc tatttcgagt gccagaaact atcgcctgac      660

cagcgcatct tcatctatgt aggaacagaa gaagcagatg atacagacaa gaccttgatg      720

gatggcaata tcaaacaagc ctatatcgac tcgtcgcttt gctattacca tgatttgata      780

gcagggggag tacatctgga taatcttgtg ctaaaagttc agtctggtgc catccatagt      840

gaaatccctt ggtcagaaaa tctaccagat tgtctgagat tttttgcaga aaaatggtaa      900


<210>  45
<211>  465
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP0882N with exogenous signal sequence

<400>  45
atgtcatcta aatttatgaa gagcgctgcg gtgcttggaa ctgctacact tgctagcttg       60

cttttggtag cttgcatgaa tcaatcctac ttttatctaa aaatgaaaga acacaaactc      120

aaggttcctt atacaggtaa ggagcgccgt gtacgtattc ttcttcctaa agattatgag      180

aaagatacag accgttccta tcctgttgta tactttcatg acgggcaaaa tgtttttaat      240

agcaaagagt ctttcattgg acattcatgg aagattatcc cagctatcaa acgaaatccg      300

gatatcagtc gcatgattgt cgttgctatt gacaatgatg gtatggggcg gatgaatgag      360

tatgcggctt ggaagttcca agaatctcct atcccagggc agcagtttgg tggtaagggt      420

gtggagtatg ctgagtttgt catggaggtg gtcaagcctt ttatc                      465


<210>  46
<211>  2046
<212>  DNA
<213>  Streptococcus pneumoniae

<400>  46
ttgacaaata tttacggagg aggcttatgc ttaatataag tataggctaa aaatgattat       60

cagaaaagag gtaaatttag atgaataaga aaaaaatgat tttaacaagc ctagccagcg      120

tcgctatctt aggggctggt tttgttgcgt cttcgcctac ttttgtaaga gcagaagaag      180

ctcctgtagc taaccagtct aaagctgaga aagactatga tgcagcagtg aaaaaatctg      240

aagctgctaa gaaagattac gaaacggcta aaaagaaagc agaagacgct cagaagaaat      300

atgatgagga tcagaagaaa actgaggcaa aagcggaaaa agaaagaaaa gcttctgaaa      360

agatagctga ggcaacaaaa gaagttcaac aagcgtacct agcttatcta caagctagca      420

acgaaagtca gagaaaagag gcagataaga agataaaaga agctacgcaa cgcaaagatg      480

aggcggaagc tgcatttgct actattcgaa caacaattgt agttcctgaa ccaagtgagt      540

tagctgagac taagaaaaaa gcagaagagg caacaaaaga agcagaagta gctaagaaaa      600

aatctgaaga ggcagctaaa gaggtagaag tagagaaaaa taaaatactt gaacaagatg      660

ctgaaaacga aaagaaaatt gacgtacttc aaaacaaagt cgctgattta gaaaaaggaa      720

ttgctcctta tcaaaacgaa gtcgctgaat taaataaaga aattgctaga cttcaaagcg      780

atttaaaaga tgctgaagaa aataatgtag aagactacat taaagaaggt ttagagcaag      840

ctatcactaa taaaaaagct gaattagcta caactcaaca aaacatagat aaaactcaaa      900

aagatttaga ggatgctgaa ttagaacttg aaaaagtatt agctacatta gaccctgaag      960

gtaaaactca agatgaatta gataaagaag ctgctgaagc tgagttgaat gaaaaagttg     1020

aagctcttca aaaccaagtt gctgaattag aagaagaact ttcaaaactt gaagataatc     1080

ttaaagatgc tgaaacaaac aacgttgaag actacattaa agaaggttta gaagaagcta     1140

tcgcgactaa aaaagctgaa ttggaaaaaa ctcaaaaaga attagatgca gctcttaatg     1200

agttaggccc tgatggagat gaagaagaga ctccagcgcc ggctcctcaa ccagaaaaac     1260

cagctgaaga gcctgagaat ccagctccag caccaaaacc agagaagtca gcagatcaac     1320

aagctgaaga agactatgct cgtagatcag aagaagaata taatcgcttg acccaacagc     1380

aaccgccaaa agcagaaaaa ccagctcctg caccacaacc agagcaacca gctcctgcac     1440

caaaaatagg ttggaaacaa gaaaacggta tgtggtactt ctacaatact gatggttcaa     1500

tggcgacagg ttggctacaa aacaacggtt catggtacta cctcaacagc aatggcgcta     1560

tggctacagg ttggctccaa tacaatggtt catggtatta cctaaacgct aacggcgcta     1620

tggcgacagg ctggctccaa tacaatggct catggtacta cctcaacgct aacggcgcta     1680

tggcgacagg ctggctccaa tacaatggct catggtacta cctcaacgct aatggtgata     1740

tggcgacagg atggctccaa tacaacggtt catggtatta cctcaacgct aatggtgata     1800

tggctacagg ttgggctaaa gtccacggtt catggtacta cctcaacgct aacggttcaa     1860

tggcaacagg ttgggtgaaa gatggagaaa cctggtacta tcttgaagca tcaggttcta     1920

tgaaagcaaa ccaatggttc caagtatcag ataaatggta ctatgtcaat ggtttaggtt     1980

ccctttcagt caacacaact gtagatggct ataaagtcaa tgccaatggt gaatgggttt     2040

aagccg                                                                2046


<210>  47
<211>  675
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP2108/SP0148 fusion protein

<400>  47

Met Ser Ser Lys Phe Met Lys Ser Ala Ala Val Leu Gly Thr Ala Thr 
1               5                   10                  15      


Leu Ala Ser Leu Leu Leu Val Ala Cys Gly Ser Lys Thr Ala Asp Lys 
            20                  25                  30          


Pro Ala Asp Ser Gly Ser Ser Glu Val Lys Glu Leu Thr Val Tyr Val 
        35                  40                  45              


Asp Glu Gly Tyr Lys Ser Tyr Ile Glu Glu Val Ala Lys Ala Tyr Glu 
    50                  55                  60                  


Lys Glu Ala Gly Val Lys Val Thr Leu Lys Thr Gly Asp Ala Leu Gly 
65                  70                  75                  80  


Gly Leu Asp Lys Leu Ser Leu Asp Asn Gln Ser Gly Asn Val Pro Asp 
                85                  90                  95      


Val Met Met Ala Pro Tyr Asp Arg Val Gly Ser Leu Gly Ser Asp Gly 
            100                 105                 110         


Gln Leu Ser Glu Val Lys Leu Ser Asp Gly Ala Lys Thr Asp Asp Thr 
        115                 120                 125             


Thr Lys Ser Leu Val Thr Ala Ala Asn Gly Lys Val Tyr Gly Ala Pro 
    130                 135                 140                 


Ala Val Ile Glu Ser Leu Val Met Tyr Tyr Asn Lys Asp Leu Val Lys 
145                 150                 155                 160 


Asp Ala Pro Lys Thr Phe Ala Asp Leu Glu Asn Leu Ala Lys Asp Ser 
                165                 170                 175     


Lys Tyr Ala Phe Ala Gly Glu Asp Gly Lys Thr Thr Ala Phe Leu Ala 
            180                 185                 190         


Asp Trp Thr Asn Phe Tyr Tyr Thr Tyr Gly Leu Leu Ala Gly Asn Gly 
        195                 200                 205             


Ala Tyr Val Phe Gly Gln Asn Gly Lys Asp Ala Lys Asp Ile Gly Leu 
    210                 215                 220                 


Ala Asn Asp Gly Ser Ile Val Gly Ile Asn Tyr Ala Lys Ser Trp Tyr 
225                 230                 235                 240 


Glu Lys Trp Pro Lys Gly Met Gln Asp Thr Glu Gly Ala Gly Asn Leu 
                245                 250                 255     


Ile Gln Thr Gln Phe Gln Glu Gly Lys Thr Ala Ala Ile Ile Asp Gly 
            260                 265                 270         


Pro Trp Lys Ala Gln Ala Phe Lys Asp Ala Lys Val Asn Tyr Gly Val 
        275                 280                 285             


Ala Thr Ile Pro Thr Leu Pro Asn Gly Lys Glu Tyr Ala Ala Phe Gly 
    290                 295                 300                 


Gly Gly Lys Ala Trp Val Ile Pro Gln Ala Val Lys Asn Leu Glu Ala 
305                 310                 315                 320 


Ser Gln Lys Phe Val Asp Phe Leu Val Ala Thr Glu Gln Gln Lys Val 
                325                 330                 335     


Leu Tyr Asp Lys Thr Asn Glu Ile Pro Ala Asn Thr Glu Ala Arg Ser 
            340                 345                 350         


Tyr Ala Glu Gly Lys Asn Asp Glu Leu Thr Thr Ala Val Ile Lys Gln 
        355                 360                 365             


Phe Lys Asn Thr Gln Pro Leu Pro Asn Ile Ser Gln Met Ser Ala Val 
    370                 375                 380                 


Trp Asp Pro Ala Lys Asn Met Leu Phe Asp Ala Val Ser Gly Gln Lys 
385                 390                 395                 400 


Asp Ala Lys Thr Ala Ala Asn Asp Ala Val Thr Leu Ile Lys Glu Thr 
                405                 410                 415     


Ile Lys Gln Lys Phe Gly Glu Ser Gly Gly Ala Lys Lys Glu Gly Glu 
            420                 425                 430         


Ala Ala Ser Lys Lys Glu Ile Ile Val Ala Thr Asn Gly Ser Pro Lys 
        435                 440                 445             


Pro Phe Ile Tyr Glu Glu Asn Gly Glu Leu Thr Gly Tyr Glu Ile Glu 
    450                 455                 460                 


Val Val Arg Ala Ile Phe Lys Asp Ser Asp Lys Tyr Asp Val Lys Phe 
465                 470                 475                 480 


Glu Lys Thr Glu Trp Ser Gly Val Phe Ala Gly Leu Asp Ala Asp Arg 
                485                 490                 495     


Tyr Asn Met Ala Val Asn Asn Leu Ser Tyr Thr Lys Glu Arg Ala Glu 
            500                 505                 510         


Lys Tyr Leu Tyr Ala Ala Pro Ile Ala Gln Asn Pro Asn Val Leu Val 
        515                 520                 525             


Val Lys Lys Asp Asp Ser Ser Ile Lys Ser Leu Asp Asp Ile Gly Gly 
    530                 535                 540                 


Lys Ser Thr Glu Val Val Gln Ala Thr Thr Ser Ala Lys Gln Leu Glu 
545                 550                 555                 560 


Ala Tyr Asn Ala Glu His Thr Asp Asn Pro Thr Ile Leu Asn Tyr Thr 
                565                 570                 575     


Lys Ala Asp Phe Gln Gln Ile Met Val Arg Leu Ser Asp Gly Gln Phe 
            580                 585                 590         


Asp Tyr Lys Ile Phe Asp Lys Ile Gly Val Glu Thr Val Ile Lys Asn 
        595                 600                 605             


Gln Gly Leu Asp Asn Leu Lys Val Ile Glu Leu Pro Ser Asp Gln Gln 
    610                 615                 620                 


Pro Tyr Val Tyr Pro Leu Leu Ala Gln Gly Gln Asp Glu Leu Lys Ser 
625                 630                 635                 640 


Phe Val Asp Lys Arg Ile Lys Glu Leu Tyr Lys Asp Gly Thr Leu Glu 
                645                 650                 655     


Lys Leu Ser Lys Gln Phe Phe Gly Asp Thr Tyr Leu Pro Ala Glu Ala 
            660                 665                 670         


Asp Ile Lys 
        675 


<210>  48
<211>  674
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP0148/SP2108 fusion protein

<400>  48

Met Lys Lys Ile Val Lys Tyr Ser Ser Leu Ala Ala Leu Ala Leu Val 
1               5                   10                  15      


Ala Ala Gly Val Leu Ala Ala Cys Ser Gly Gly Ala Lys Lys Glu Gly 
            20                  25                  30          


Glu Ala Ala Ser Lys Lys Glu Ile Ile Val Ala Thr Asn Gly Ser Pro 
        35                  40                  45              


Lys Pro Phe Ile Tyr Glu Glu Asn Gly Glu Leu Thr Gly Tyr Glu Ile 
    50                  55                  60                  


Glu Val Val Arg Ala Ile Phe Lys Asp Ser Asp Lys Tyr Asp Val Lys 
65                  70                  75                  80  


Phe Glu Lys Thr Glu Trp Ser Gly Val Phe Ala Gly Leu Asp Ala Asp 
                85                  90                  95      


Arg Tyr Asn Met Ala Val Asn Asn Leu Ser Tyr Thr Lys Glu Arg Ala 
            100                 105                 110         


Glu Lys Tyr Leu Tyr Ala Ala Pro Ile Ala Gln Asn Pro Asn Val Leu 
        115                 120                 125             


Val Val Lys Lys Asp Asp Ser Ser Ile Lys Ser Leu Asp Asp Ile Gly 
    130                 135                 140                 


Gly Lys Ser Thr Glu Val Val Gln Ala Thr Thr Ser Ala Lys Gln Leu 
145                 150                 155                 160 


Glu Ala Tyr Asn Ala Glu His Thr Asp Asn Pro Thr Ile Leu Asn Tyr 
                165                 170                 175     


Thr Lys Ala Asp Phe Gln Gln Ile Met Val Arg Leu Ser Asp Gly Gln 
            180                 185                 190         


Phe Asp Tyr Lys Ile Phe Asp Lys Ile Gly Val Glu Thr Val Ile Lys 
        195                 200                 205             


Asn Gln Gly Leu Asp Asn Leu Lys Val Ile Glu Leu Pro Ser Asp Gln 
    210                 215                 220                 


Gln Pro Tyr Val Tyr Pro Leu Leu Ala Gln Gly Gln Asp Glu Leu Lys 
225                 230                 235                 240 


Ser Phe Val Asp Lys Arg Ile Lys Glu Leu Tyr Lys Asp Gly Thr Leu 
                245                 250                 255     


Glu Lys Leu Ser Lys Gln Phe Phe Gly Asp Thr Tyr Leu Pro Ala Glu 
            260                 265                 270         


Ala Asp Ile Lys Gly Ser Lys Thr Ala Asp Lys Pro Ala Asp Ser Gly 
        275                 280                 285             


Ser Ser Glu Val Lys Glu Leu Thr Val Tyr Val Asp Glu Gly Tyr Lys 
    290                 295                 300                 


Ser Tyr Ile Glu Glu Val Ala Lys Ala Tyr Glu Lys Glu Ala Gly Val 
305                 310                 315                 320 


Lys Val Thr Leu Lys Thr Gly Asp Ala Leu Gly Gly Leu Asp Lys Leu 
                325                 330                 335     


Ser Leu Asp Asn Gln Ser Gly Asn Val Pro Asp Val Met Met Ala Pro 
            340                 345                 350         


Tyr Asp Arg Val Gly Ser Leu Gly Ser Asp Gly Gln Leu Ser Glu Val 
        355                 360                 365             


Lys Leu Ser Asp Gly Ala Lys Thr Asp Asp Thr Thr Lys Ser Leu Val 
    370                 375                 380                 


Thr Ala Ala Asn Gly Lys Val Tyr Gly Ala Pro Ala Val Ile Glu Ser 
385                 390                 395                 400 


Leu Val Met Tyr Tyr Asn Lys Asp Leu Val Lys Asp Ala Pro Lys Thr 
                405                 410                 415     


Phe Ala Asp Leu Glu Asn Leu Ala Lys Asp Ser Lys Tyr Ala Phe Ala 
            420                 425                 430         


Gly Glu Asp Gly Lys Thr Thr Ala Phe Leu Ala Asp Trp Thr Asn Phe 
        435                 440                 445             


Tyr Tyr Thr Tyr Gly Leu Leu Ala Gly Asn Gly Ala Tyr Val Phe Gly 
    450                 455                 460                 


Gln Asn Gly Lys Asp Ala Lys Asp Ile Gly Leu Ala Asn Asp Gly Ser 
465                 470                 475                 480 


Ile Val Gly Ile Asn Tyr Ala Lys Ser Trp Tyr Glu Lys Trp Pro Lys 
                485                 490                 495     


Gly Met Gln Asp Thr Glu Gly Ala Gly Asn Leu Ile Gln Thr Gln Phe 
            500                 505                 510         


Gln Glu Gly Lys Thr Ala Ala Ile Ile Asp Gly Pro Trp Lys Ala Gln 
        515                 520                 525             


Ala Phe Lys Asp Ala Lys Val Asn Tyr Gly Val Ala Thr Ile Pro Thr 
    530                 535                 540                 


Leu Pro Asn Gly Lys Glu Tyr Ala Ala Phe Gly Gly Gly Lys Ala Trp 
545                 550                 555                 560 


Val Ile Pro Gln Ala Val Lys Asn Leu Glu Ala Ser Gln Lys Phe Val 
                565                 570                 575     


Asp Phe Leu Val Ala Thr Glu Gln Gln Lys Val Leu Tyr Asp Lys Thr 
            580                 585                 590         


Asn Glu Ile Pro Ala Asn Thr Glu Ala Arg Ser Tyr Ala Glu Gly Lys 
        595                 600                 605             


Asn Asp Glu Leu Thr Thr Ala Val Ile Lys Gln Phe Lys Asn Thr Gln 
    610                 615                 620                 


Pro Leu Pro Asn Ile Ser Gln Met Ser Ala Val Trp Asp Pro Ala Lys 
625                 630                 635                 640 


Asn Met Leu Phe Asp Ala Val Ser Gly Gln Lys Asp Ala Lys Thr Ala 
                645                 650                 655     


Ala Asn Asp Ala Val Thr Leu Ile Lys Glu Thr Ile Lys Gln Lys Phe 
            660                 665                 670         


Gly Glu 
        


<210>  49
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP2108/SP1912 fusion protein

<400>  49

Met Ser Ser Lys Phe Met Lys Ser Ala Ala Val Leu Gly Thr Ala Thr 
1               5                   10                  15      


Leu Ala Ser Leu Leu Leu Val Ala Cys Gly Ser Lys Thr Ala Asp Lys 
            20                  25                  30          


Pro Ala Asp Ser Gly Ser Ser Glu Val Lys Glu Leu Thr Val Tyr Val 
        35                  40                  45              


Asp Glu Gly Tyr Lys Ser Tyr Ile Glu Glu Val Ala Lys Ala Tyr Glu 
    50                  55                  60                  


Lys Glu Ala Gly Val Lys Val Thr Leu Lys Thr Gly Asp Ala Leu Gly 
65                  70                  75                  80  


Gly Leu Asp Lys Leu Ser Leu Asp Asn Gln Ser Gly Asn Val Pro Asp 
                85                  90                  95      


Val Met Met Ala Pro Tyr Asp Arg Val Gly Ser Leu Gly Ser Asp Gly 
            100                 105                 110         


Gln Leu Ser Glu Val Lys Leu Ser Asp Gly Ala Lys Thr Asp Asp Thr 
        115                 120                 125             


Thr Lys Ser Leu Val Thr Ala Ala Asn Gly Lys Val Tyr Gly Ala Pro 
    130                 135                 140                 


Ala Val Ile Glu Ser Leu Val Met Tyr Tyr Asn Lys Asp Leu Val Lys 
145                 150                 155                 160 


Asp Ala Pro Lys Thr Phe Ala Asp Leu Glu Asn Leu Ala Lys Asp Ser 
                165                 170                 175     


Lys Tyr Ala Phe Ala Gly Glu Asp Gly Lys Thr Thr Ala Phe Leu Ala 
            180                 185                 190         


Asp Trp Thr Asn Phe Tyr Tyr Thr Tyr Gly Leu Leu Ala Gly Asn Gly 
        195                 200                 205             


Ala Tyr Val Phe Gly Gln Asn Gly Lys Asp Ala Lys Asp Ile Gly Leu 
    210                 215                 220                 


Ala Asn Asp Gly Ser Ile Val Gly Ile Asn Tyr Ala Lys Ser Trp Tyr 
225                 230                 235                 240 


Glu Lys Trp Pro Lys Gly Met Gln Asp Thr Glu Gly Ala Gly Asn Leu 
                245                 250                 255     


Ile Gln Thr Gln Phe Gln Glu Gly Lys Thr Ala Ala Ile Ile Asp Gly 
            260                 265                 270         


Pro Trp Lys Ala Gln Ala Phe Lys Asp Ala Lys Val Asn Tyr Gly Val 
        275                 280                 285             


Ala Thr Ile Pro Thr Leu Pro Asn Gly Lys Glu Tyr Ala Ala Phe Gly 
    290                 295                 300                 


Gly Gly Lys Ala Trp Val Ile Pro Gln Ala Val Lys Asn Leu Glu Ala 
305                 310                 315                 320 


Ser Gln Lys Phe Val Asp Phe Leu Val Ala Thr Glu Gln Gln Lys Val 
                325                 330                 335     


Leu Tyr Asp Lys Thr Asn Glu Ile Pro Ala Asn Thr Glu Ala Arg Ser 
            340                 345                 350         


Tyr Ala Glu Gly Lys Asn Asp Glu Leu Thr Thr Ala Val Ile Lys Gln 
        355                 360                 365             


Phe Lys Asn Thr Gln Pro Leu Pro Asn Ile Ser Gln Met Ser Ala Val 
    370                 375                 380                 


Trp Asp Pro Ala Lys Asn Met Leu Phe Asp Ala Val Ser Gly Gln Lys 
385                 390                 395                 400 


Asp Ala Lys Thr Ala Ala Asn Asp Ala Val Thr Leu Ile Lys Glu Thr 
                405                 410                 415     


Ile Lys Gln Lys Phe Gly Glu Asn Gly Met Lys Ala Lys Lys Met Trp 
            420                 425                 430         


Met Ala Gly Leu Ala Leu Leu Gly Ile Gly Ser Leu Ala Leu Ala Thr 
        435                 440                 445             


Lys Lys Val Ala Asp Asp Arg Lys Leu Met Lys Thr Gln Glu Glu Leu 
    450                 455                 460                 


Thr Glu Ile Val Arg Asp His Phe Ser Asp Met Gly Glu Ile Ala Thr 
465                 470                 475                 480 


Leu Tyr Val Gln Val Tyr Glu Ser Ser Leu Glu Ser Leu Val Gly Gly 
                485                 490                 495     


Val Ile Phe Glu Asp Gly Arg His Tyr Thr Phe Val Tyr Glu Asn Glu 
            500                 505                 510         


Asp Leu Val Tyr Glu Glu Glu Val Leu 
        515                 520     


<210>  50
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP0148/SP1912 fusion protein

<400>  50

Met Lys Lys Ile Val Lys Tyr Ser Ser Leu Ala Ala Leu Ala Leu Val 
1               5                   10                  15      


Ala Ala Gly Val Leu Ala Ala Cys Ser Gly Gly Ala Lys Lys Glu Gly 
            20                  25                  30          


Glu Ala Ala Ser Lys Lys Glu Ile Ile Val Ala Thr Asn Gly Ser Pro 
        35                  40                  45              


Lys Pro Phe Ile Tyr Glu Glu Asn Gly Glu Leu Thr Gly Tyr Glu Ile 
    50                  55                  60                  


Glu Val Val Arg Ala Ile Phe Lys Asp Ser Asp Lys Tyr Asp Val Lys 
65                  70                  75                  80  


Phe Glu Lys Thr Glu Trp Ser Gly Val Phe Ala Gly Leu Asp Ala Asp 
                85                  90                  95      


Arg Tyr Asn Met Ala Val Asn Asn Leu Ser Tyr Thr Lys Glu Arg Ala 
            100                 105                 110         


Glu Lys Tyr Leu Tyr Ala Ala Pro Ile Ala Gln Asn Pro Asn Val Leu 
        115                 120                 125             


Val Val Lys Lys Asp Asp Ser Ser Ile Lys Ser Leu Asp Asp Ile Gly 
    130                 135                 140                 


Gly Lys Ser Thr Glu Val Val Gln Ala Thr Thr Ser Ala Lys Gln Leu 
145                 150                 155                 160 


Glu Ala Tyr Asn Ala Glu His Thr Asp Asn Pro Thr Ile Leu Asn Tyr 
                165                 170                 175     


Thr Lys Ala Asp Phe Gln Gln Ile Met Val Arg Leu Ser Asp Gly Gln 
            180                 185                 190         


Phe Asp Tyr Lys Ile Phe Asp Lys Ile Gly Val Glu Thr Val Ile Lys 
        195                 200                 205             


Asn Gln Gly Leu Asp Asn Leu Lys Val Ile Glu Leu Pro Ser Asp Gln 
    210                 215                 220                 


Gln Pro Tyr Val Tyr Pro Leu Leu Ala Gln Gly Gln Asp Glu Leu Lys 
225                 230                 235                 240 


Ser Phe Val Asp Lys Arg Ile Lys Glu Leu Tyr Lys Asp Gly Thr Leu 
                245                 250                 255     


Glu Lys Leu Ser Lys Gln Phe Phe Gly Asp Thr Tyr Leu Pro Ala Glu 
            260                 265                 270         


Ala Asp Ile Lys Asn Gly Met Lys Ala Lys Lys Met Trp Met Ala Gly 
        275                 280                 285             


Leu Ala Leu Leu Gly Ile Gly Ser Leu Ala Leu Ala Thr Lys Lys Val 
    290                 295                 300                 


Ala Asp Asp Arg Lys Leu Met Lys Thr Gln Glu Glu Leu Thr Glu Ile 
305                 310                 315                 320 


Val Arg Asp His Phe Ser Asp Met Gly Glu Ile Ala Thr Leu Tyr Val 
                325                 330                 335     


Gln Val Tyr Glu Ser Ser Leu Glu Ser Leu Val Gly Gly Val Ile Phe 
            340                 345                 350         


Glu Asp Gly Arg His Tyr Thr Phe Val Tyr Glu Asn Glu Asp Leu Val 
        355                 360                 365             


Tyr Glu Glu Glu Val Leu 
    370                 


<210>  51
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP2108/SP1912/SP0148 fusion protein

<400>  51

Met Ser Ser Lys Phe Met Lys Ser Ala Ala Val Leu Gly Thr Ala Thr 
1               5                   10                  15      


Leu Ala Ser Leu Leu Leu Val Ala Cys Gly Ser Lys Thr Ala Asp Lys 
            20                  25                  30          


Pro Ala Asp Ser Gly Ser Ser Glu Val Lys Glu Leu Thr Val Tyr Val 
        35                  40                  45              


Asp Glu Gly Tyr Lys Ser Tyr Ile Glu Glu Val Ala Lys Ala Tyr Glu 
    50                  55                  60                  


Lys Glu Ala Gly Val Lys Val Thr Leu Lys Thr Gly Asp Ala Leu Gly 
65                  70                  75                  80  


Gly Leu Asp Lys Leu Ser Leu Asp Asn Gln Ser Gly Asn Val Pro Asp 
                85                  90                  95      


Val Met Met Ala Pro Tyr Asp Arg Val Gly Ser Leu Gly Ser Asp Gly 
            100                 105                 110         


Gln Leu Ser Glu Val Lys Leu Ser Asp Gly Ala Lys Thr Asp Asp Thr 
        115                 120                 125             


Thr Lys Ser Leu Val Thr Ala Ala Asn Gly Lys Val Tyr Gly Ala Pro 
    130                 135                 140                 


Ala Val Ile Glu Ser Leu Val Met Tyr Tyr Asn Lys Asp Leu Val Lys 
145                 150                 155                 160 


Asp Ala Pro Lys Thr Phe Ala Asp Leu Glu Asn Leu Ala Lys Asp Ser 
                165                 170                 175     


Lys Tyr Ala Phe Ala Gly Glu Asp Gly Lys Thr Thr Ala Phe Leu Ala 
            180                 185                 190         


Asp Trp Thr Asn Phe Tyr Tyr Thr Tyr Gly Leu Leu Ala Gly Asn Gly 
        195                 200                 205             


Ala Tyr Val Phe Gly Gln Asn Gly Lys Asp Ala Lys Asp Ile Gly Leu 
    210                 215                 220                 


Ala Asn Asp Gly Ser Ile Val Gly Ile Asn Tyr Ala Lys Ser Trp Tyr 
225                 230                 235                 240 


Glu Lys Trp Pro Lys Gly Met Gln Asp Thr Glu Gly Ala Gly Asn Leu 
                245                 250                 255     


Ile Gln Thr Gln Phe Gln Glu Gly Lys Thr Ala Ala Ile Ile Asp Gly 
            260                 265                 270         


Pro Trp Lys Ala Gln Ala Phe Lys Asp Ala Lys Val Asn Tyr Gly Val 
        275                 280                 285             


Ala Thr Ile Pro Thr Leu Pro Asn Gly Lys Glu Tyr Ala Ala Phe Gly 
    290                 295                 300                 


Gly Gly Lys Ala Trp Val Ile Pro Gln Ala Val Lys Asn Leu Glu Ala 
305                 310                 315                 320 


Ser Gln Lys Phe Val Asp Phe Leu Val Ala Thr Glu Gln Gln Lys Val 
                325                 330                 335     


Leu Tyr Asp Lys Thr Asn Glu Ile Pro Ala Asn Thr Glu Ala Arg Ser 
            340                 345                 350         


Tyr Ala Glu Gly Lys Asn Asp Glu Leu Thr Thr Ala Val Ile Lys Gln 
        355                 360                 365             


Phe Lys Asn Thr Gln Pro Leu Pro Asn Ile Ser Gln Met Ser Ala Val 
    370                 375                 380                 


Trp Asp Pro Ala Lys Asn Met Leu Phe Asp Ala Val Ser Gly Gln Lys 
385                 390                 395                 400 


Asp Ala Lys Thr Ala Ala Asn Asp Ala Val Thr Leu Ile Lys Glu Thr 
                405                 410                 415     


Ile Lys Gln Lys Phe Gly Glu Asn Gly Met Lys Ala Lys Lys Met Trp 
            420                 425                 430         


Met Ala Gly Leu Ala Leu Leu Gly Ile Gly Ser Leu Ala Leu Ala Thr 
        435                 440                 445             


Lys Lys Val Ala Asp Asp Arg Lys Leu Met Lys Thr Gln Glu Glu Leu 
    450                 455                 460                 


Thr Glu Ile Val Arg Asp His Phe Ser Asp Met Gly Glu Ile Ala Thr 
465                 470                 475                 480 


Leu Tyr Val Gln Val Tyr Glu Ser Ser Leu Glu Ser Leu Val Gly Gly 
                485                 490                 495     


Val Ile Phe Glu Asp Gly Arg His Tyr Thr Phe Val Tyr Glu Asn Glu 
            500                 505                 510         


Asp Leu Val Tyr Glu Glu Glu Val Leu Ser Gly Gly Ala Lys Lys Glu 
        515                 520                 525             


Gly Glu Ala Ala Ser Lys Lys Glu Ile Ile Val Ala Thr Asn Gly Ser 
    530                 535                 540                 


Pro Lys Pro Phe Ile Tyr Glu Glu Asn Gly Glu Leu Thr Gly Tyr Glu 
545                 550                 555                 560 


Ile Glu Val Val Arg Ala Ile Phe Lys Asp Ser Asp Lys Tyr Asp Val 
                565                 570                 575     


Lys Phe Glu Lys Thr Glu Trp Ser Gly Val Phe Ala Gly Leu Asp Ala 
            580                 585                 590         


Asp Arg Tyr Asn Met Ala Val Asn Asn Leu Ser Tyr Thr Lys Glu Arg 
        595                 600                 605             


Ala Glu Lys Tyr Leu Tyr Ala Ala Pro Ile Ala Gln Asn Pro Asn Val 
    610                 615                 620                 


Leu Val Val Lys Lys Asp Asp Ser Ser Ile Lys Ser Leu Asp Asp Ile 
625                 630                 635                 640 


Gly Gly Lys Ser Thr Glu Val Val Gln Ala Thr Thr Ser Ala Lys Gln 
                645                 650                 655     


Leu Glu Ala Tyr Asn Ala Glu His Thr Asp Asn Pro Thr Ile Leu Asn 
            660                 665                 670         


Tyr Thr Lys Ala Asp Phe Gln Gln Ile Met Val Arg Leu Ser Asp Gly 
        675                 680                 685             


Gln Phe Asp Tyr Lys Ile Phe Asp Lys Ile Gly Val Glu Thr Val Ile 
    690                 695                 700                 


Lys Asn Gln Gly Leu Asp Asn Leu Lys Val Ile Glu Leu Pro Ser Asp 
705                 710                 715                 720 


Gln Gln Pro Tyr Val Tyr Pro Leu Leu Ala Gln Gly Gln Asp Glu Leu 
                725                 730                 735     


Lys Ser Phe Val Asp Lys Arg Ile Lys Glu Leu Tyr Lys Asp Gly Thr 
            740                 745                 750         


Leu Glu Lys Leu Ser Lys Gln Phe Phe Gly Asp Thr Tyr Leu Pro Ala 
        755                 760                 765             


Glu Ala Asp Ile Lys 
    770             


<210>  52
<211>  772
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP0148/SP1912/SP2108 fusion protein

<400>  52

Met Lys Lys Ile Val Lys Tyr Ser Ser Leu Ala Ala Leu Ala Leu Val 
1               5                   10                  15      


Ala Ala Gly Val Leu Ala Ala Cys Ser Gly Gly Ala Lys Lys Glu Gly 
            20                  25                  30          


Glu Ala Ala Ser Lys Lys Glu Ile Ile Val Ala Thr Asn Gly Ser Pro 
        35                  40                  45              


Lys Pro Phe Ile Tyr Glu Glu Asn Gly Glu Leu Thr Gly Tyr Glu Ile 
    50                  55                  60                  


Glu Val Val Arg Ala Ile Phe Lys Asp Ser Asp Lys Tyr Asp Val Lys 
65                  70                  75                  80  


Phe Glu Lys Thr Glu Trp Ser Gly Val Phe Ala Gly Leu Asp Ala Asp 
                85                  90                  95      


Arg Tyr Asn Met Ala Val Asn Asn Leu Ser Tyr Thr Lys Glu Arg Ala 
            100                 105                 110         


Glu Lys Tyr Leu Tyr Ala Ala Pro Ile Ala Gln Asn Pro Asn Val Leu 
        115                 120                 125             


Val Val Lys Lys Asp Asp Ser Ser Ile Lys Ser Leu Asp Asp Ile Gly 
    130                 135                 140                 


Gly Lys Ser Thr Glu Val Val Gln Ala Thr Thr Ser Ala Lys Gln Leu 
145                 150                 155                 160 


Glu Ala Tyr Asn Ala Glu His Thr Asp Asn Pro Thr Ile Leu Asn Tyr 
                165                 170                 175     


Thr Lys Ala Asp Phe Gln Gln Ile Met Val Arg Leu Ser Asp Gly Gln 
            180                 185                 190         


Phe Asp Tyr Lys Ile Phe Asp Lys Ile Gly Val Glu Thr Val Ile Lys 
        195                 200                 205             


Asn Gln Gly Leu Asp Asn Leu Lys Val Ile Glu Leu Pro Ser Asp Gln 
    210                 215                 220                 


Gln Pro Tyr Val Tyr Pro Leu Leu Ala Gln Gly Gln Asp Glu Leu Lys 
225                 230                 235                 240 


Ser Phe Val Asp Lys Arg Ile Lys Glu Leu Tyr Lys Asp Gly Thr Leu 
                245                 250                 255     


Glu Lys Leu Ser Lys Gln Phe Phe Gly Asp Thr Tyr Leu Pro Ala Glu 
            260                 265                 270         


Ala Asp Ile Lys Asn Gly Met Lys Ala Lys Lys Met Trp Met Ala Gly 
        275                 280                 285             


Leu Ala Leu Leu Gly Ile Gly Ser Leu Ala Leu Ala Thr Lys Lys Val 
    290                 295                 300                 


Ala Asp Asp Arg Lys Leu Met Lys Thr Gln Glu Glu Leu Thr Glu Ile 
305                 310                 315                 320 


Val Arg Asp His Phe Ser Asp Met Gly Glu Ile Ala Thr Leu Tyr Val 
                325                 330                 335     


Gln Val Tyr Glu Ser Ser Leu Glu Ser Leu Val Gly Gly Val Ile Phe 
            340                 345                 350         


Glu Asp Gly Arg His Tyr Thr Phe Val Tyr Glu Asn Glu Asp Leu Val 
        355                 360                 365             


Tyr Glu Glu Glu Val Leu Gly Ser Lys Thr Ala Asp Lys Pro Ala Asp 
    370                 375                 380                 


Ser Gly Ser Ser Glu Val Lys Glu Leu Thr Val Tyr Val Asp Glu Gly 
385                 390                 395                 400 


Tyr Lys Ser Tyr Ile Glu Glu Val Ala Lys Ala Tyr Glu Lys Glu Ala 
                405                 410                 415     


Gly Val Lys Val Thr Leu Lys Thr Gly Asp Ala Leu Gly Gly Leu Asp 
            420                 425                 430         


Lys Leu Ser Leu Asp Asn Gln Ser Gly Asn Val Pro Asp Val Met Met 
        435                 440                 445             


Ala Pro Tyr Asp Arg Val Gly Ser Leu Gly Ser Asp Gly Gln Leu Ser 
    450                 455                 460                 


Glu Val Lys Leu Ser Asp Gly Ala Lys Thr Asp Asp Thr Thr Lys Ser 
465                 470                 475                 480 


Leu Val Thr Ala Ala Asn Gly Lys Val Tyr Gly Ala Pro Ala Val Ile 
                485                 490                 495     


Glu Ser Leu Val Met Tyr Tyr Asn Lys Asp Leu Val Lys Asp Ala Pro 
            500                 505                 510         


Lys Thr Phe Ala Asp Leu Glu Asn Leu Ala Lys Asp Ser Lys Tyr Ala 
        515                 520                 525             


Phe Ala Gly Glu Asp Gly Lys Thr Thr Ala Phe Leu Ala Asp Trp Thr 
    530                 535                 540                 


Asn Phe Tyr Tyr Thr Tyr Gly Leu Leu Ala Gly Asn Gly Ala Tyr Val 
545                 550                 555                 560 


Phe Gly Gln Asn Gly Lys Asp Ala Lys Asp Ile Gly Leu Ala Asn Asp 
                565                 570                 575     


Gly Ser Ile Val Gly Ile Asn Tyr Ala Lys Ser Trp Tyr Glu Lys Trp 
            580                 585                 590         


Pro Lys Gly Met Gln Asp Thr Glu Gly Ala Gly Asn Leu Ile Gln Thr 
        595                 600                 605             


Gln Phe Gln Glu Gly Lys Thr Ala Ala Ile Ile Asp Gly Pro Trp Lys 
    610                 615                 620                 


Ala Gln Ala Phe Lys Asp Ala Lys Val Asn Tyr Gly Val Ala Thr Ile 
625                 630                 635                 640 


Pro Thr Leu Pro Asn Gly Lys Glu Tyr Ala Ala Phe Gly Gly Gly Lys 
                645                 650                 655     


Ala Trp Val Ile Pro Gln Ala Val Lys Asn Leu Glu Ala Ser Gln Lys 
            660                 665                 670         


Phe Val Asp Phe Leu Val Ala Thr Glu Gln Gln Lys Val Leu Tyr Asp 
        675                 680                 685             


Lys Thr Asn Glu Ile Pro Ala Asn Thr Glu Ala Arg Ser Tyr Ala Glu 
    690                 695                 700                 


Gly Lys Asn Asp Glu Leu Thr Thr Ala Val Ile Lys Gln Phe Lys Asn 
705                 710                 715                 720 


Thr Gln Pro Leu Pro Asn Ile Ser Gln Met Ser Ala Val Trp Asp Pro 
                725                 730                 735     


Ala Lys Asn Met Leu Phe Asp Ala Val Ser Gly Gln Lys Asp Ala Lys 
            740                 745                 750         


Thr Ala Ala Asn Asp Ala Val Thr Leu Ile Lys Glu Thr Ile Lys Gln 
        755                 760                 765             


Lys Phe Gly Glu 
    770         


<210>  53
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP2108/SP0148/SP1912 fusion protein

<400>  53

Met Ser Ser Lys Phe Met Lys Ser Ala Ala Val Leu Gly Thr Ala Thr 
1               5                   10                  15      


Leu Ala Ser Leu Leu Leu Val Ala Cys Gly Ser Lys Thr Ala Asp Lys 
            20                  25                  30          


Pro Ala Asp Ser Gly Ser Ser Glu Val Lys Glu Leu Thr Val Tyr Val 
        35                  40                  45              


Asp Glu Gly Tyr Lys Ser Tyr Ile Glu Glu Val Ala Lys Ala Tyr Glu 
    50                  55                  60                  


Lys Glu Ala Gly Val Lys Val Thr Leu Lys Thr Gly Asp Ala Leu Gly 
65                  70                  75                  80  


Gly Leu Asp Lys Leu Ser Leu Asp Asn Gln Ser Gly Asn Val Pro Asp 
                85                  90                  95      


Val Met Met Ala Pro Tyr Asp Arg Val Gly Ser Leu Gly Ser Asp Gly 
            100                 105                 110         


Gln Leu Ser Glu Val Lys Leu Ser Asp Gly Ala Lys Thr Asp Asp Thr 
        115                 120                 125             


Thr Lys Ser Leu Val Thr Ala Ala Asn Gly Lys Val Tyr Gly Ala Pro 
    130                 135                 140                 


Ala Val Ile Glu Ser Leu Val Met Tyr Tyr Asn Lys Asp Leu Val Lys 
145                 150                 155                 160 


Asp Ala Pro Lys Thr Phe Ala Asp Leu Glu Asn Leu Ala Lys Asp Ser 
                165                 170                 175     


Lys Tyr Ala Phe Ala Gly Glu Asp Gly Lys Thr Thr Ala Phe Leu Ala 
            180                 185                 190         


Asp Trp Thr Asn Phe Tyr Tyr Thr Tyr Gly Leu Leu Ala Gly Asn Gly 
        195                 200                 205             


Ala Tyr Val Phe Gly Gln Asn Gly Lys Asp Ala Lys Asp Ile Gly Leu 
    210                 215                 220                 


Ala Asn Asp Gly Ser Ile Val Gly Ile Asn Tyr Ala Lys Ser Trp Tyr 
225                 230                 235                 240 


Glu Lys Trp Pro Lys Gly Met Gln Asp Thr Glu Gly Ala Gly Asn Leu 
                245                 250                 255     


Ile Gln Thr Gln Phe Gln Glu Gly Lys Thr Ala Ala Ile Ile Asp Gly 
            260                 265                 270         


Pro Trp Lys Ala Gln Ala Phe Lys Asp Ala Lys Val Asn Tyr Gly Val 
        275                 280                 285             


Ala Thr Ile Pro Thr Leu Pro Asn Gly Lys Glu Tyr Ala Ala Phe Gly 
    290                 295                 300                 


Gly Gly Lys Ala Trp Val Ile Pro Gln Ala Val Lys Asn Leu Glu Ala 
305                 310                 315                 320 


Ser Gln Lys Phe Val Asp Phe Leu Val Ala Thr Glu Gln Gln Lys Val 
                325                 330                 335     


Leu Tyr Asp Lys Thr Asn Glu Ile Pro Ala Asn Thr Glu Ala Arg Ser 
            340                 345                 350         


Tyr Ala Glu Gly Lys Asn Asp Glu Leu Thr Thr Ala Val Ile Lys Gln 
        355                 360                 365             


Phe Lys Asn Thr Gln Pro Leu Pro Asn Ile Ser Gln Met Ser Ala Val 
    370                 375                 380                 


Trp Asp Pro Ala Lys Asn Met Leu Phe Asp Ala Val Ser Gly Gln Lys 
385                 390                 395                 400 


Asp Ala Lys Thr Ala Ala Asn Asp Ala Val Thr Leu Ile Lys Glu Thr 
                405                 410                 415     


Ile Lys Gln Lys Phe Gly Glu Ser Gly Gly Ala Lys Lys Glu Gly Glu 
            420                 425                 430         


Ala Ala Ser Lys Lys Glu Ile Ile Val Ala Thr Asn Gly Ser Pro Lys 
        435                 440                 445             


Pro Phe Ile Tyr Glu Glu Asn Gly Glu Leu Thr Gly Tyr Glu Ile Glu 
    450                 455                 460                 


Val Val Arg Ala Ile Phe Lys Asp Ser Asp Lys Tyr Asp Val Lys Phe 
465                 470                 475                 480 


Glu Lys Thr Glu Trp Ser Gly Val Phe Ala Gly Leu Asp Ala Asp Arg 
                485                 490                 495     


Tyr Asn Met Ala Val Asn Asn Leu Ser Tyr Thr Lys Glu Arg Ala Glu 
            500                 505                 510         


Lys Tyr Leu Tyr Ala Ala Pro Ile Ala Gln Asn Pro Asn Val Leu Val 
        515                 520                 525             


Val Lys Lys Asp Asp Ser Ser Ile Lys Ser Leu Asp Asp Ile Gly Gly 
    530                 535                 540                 


Lys Ser Thr Glu Val Val Gln Ala Thr Thr Ser Ala Lys Gln Leu Glu 
545                 550                 555                 560 


Ala Tyr Asn Ala Glu His Thr Asp Asn Pro Thr Ile Leu Asn Tyr Thr 
                565                 570                 575     


Lys Ala Asp Phe Gln Gln Ile Met Val Arg Leu Ser Asp Gly Gln Phe 
            580                 585                 590         


Asp Tyr Lys Ile Phe Asp Lys Ile Gly Val Glu Thr Val Ile Lys Asn 
        595                 600                 605             


Gln Gly Leu Asp Asn Leu Lys Val Ile Glu Leu Pro Ser Asp Gln Gln 
    610                 615                 620                 


Pro Tyr Val Tyr Pro Leu Leu Ala Gln Gly Gln Asp Glu Leu Lys Ser 
625                 630                 635                 640 


Phe Val Asp Lys Arg Ile Lys Glu Leu Tyr Lys Asp Gly Thr Leu Glu 
                645                 650                 655     


Lys Leu Ser Lys Gln Phe Phe Gly Asp Thr Tyr Leu Pro Ala Glu Ala 
            660                 665                 670         


Asp Ile Lys Asn Gly Met Lys Ala Lys Lys Met Trp Met Ala Gly Leu 
        675                 680                 685             


Ala Leu Leu Gly Ile Gly Ser Leu Ala Leu Ala Thr Lys Lys Val Ala 
    690                 695                 700                 


Asp Asp Arg Lys Leu Met Lys Thr Gln Glu Glu Leu Thr Glu Ile Val 
705                 710                 715                 720 


Arg Asp His Phe Ser Asp Met Gly Glu Ile Ala Thr Leu Tyr Val Gln 
                725                 730                 735     


Val Tyr Glu Ser Ser Leu Glu Ser Leu Val Gly Gly Val Ile Phe Glu 
            740                 745                 750         


Asp Gly Arg His Tyr Thr Phe Val Tyr Glu Asn Glu Asp Leu Val Tyr 
        755                 760                 765             


Glu Glu Glu Val Leu 
    770             


<210>  54
<211>  772
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP0148/SP2108/SP1912 fusion protein

<400>  54

Met Lys Lys Ile Val Lys Tyr Ser Ser Leu Ala Ala Leu Ala Leu Val 
1               5                   10                  15      


Ala Ala Gly Val Leu Ala Ala Cys Ser Gly Gly Ala Lys Lys Glu Gly 
            20                  25                  30          


Glu Ala Ala Ser Lys Lys Glu Ile Ile Val Ala Thr Asn Gly Ser Pro 
        35                  40                  45              


Lys Pro Phe Ile Tyr Glu Glu Asn Gly Glu Leu Thr Gly Tyr Glu Ile 
    50                  55                  60                  


Glu Val Val Arg Ala Ile Phe Lys Asp Ser Asp Lys Tyr Asp Val Lys 
65                  70                  75                  80  


Phe Glu Lys Thr Glu Trp Ser Gly Val Phe Ala Gly Leu Asp Ala Asp 
                85                  90                  95      


Arg Tyr Asn Met Ala Val Asn Asn Leu Ser Tyr Thr Lys Glu Arg Ala 
            100                 105                 110         


Glu Lys Tyr Leu Tyr Ala Ala Pro Ile Ala Gln Asn Pro Asn Val Leu 
        115                 120                 125             


Val Val Lys Lys Asp Asp Ser Ser Ile Lys Ser Leu Asp Asp Ile Gly 
    130                 135                 140                 


Gly Lys Ser Thr Glu Val Val Gln Ala Thr Thr Ser Ala Lys Gln Leu 
145                 150                 155                 160 


Glu Ala Tyr Asn Ala Glu His Thr Asp Asn Pro Thr Ile Leu Asn Tyr 
                165                 170                 175     


Thr Lys Ala Asp Phe Gln Gln Ile Met Val Arg Leu Ser Asp Gly Gln 
            180                 185                 190         


Phe Asp Tyr Lys Ile Phe Asp Lys Ile Gly Val Glu Thr Val Ile Lys 
        195                 200                 205             


Asn Gln Gly Leu Asp Asn Leu Lys Val Ile Glu Leu Pro Ser Asp Gln 
    210                 215                 220                 


Gln Pro Tyr Val Tyr Pro Leu Leu Ala Gln Gly Gln Asp Glu Leu Lys 
225                 230                 235                 240 


Ser Phe Val Asp Lys Arg Ile Lys Glu Leu Tyr Lys Asp Gly Thr Leu 
                245                 250                 255     


Glu Lys Leu Ser Lys Gln Phe Phe Gly Asp Thr Tyr Leu Pro Ala Glu 
            260                 265                 270         


Ala Asp Ile Lys Gly Ser Lys Thr Ala Asp Lys Pro Ala Asp Ser Gly 
        275                 280                 285             


Ser Ser Glu Val Lys Glu Leu Thr Val Tyr Val Asp Glu Gly Tyr Lys 
    290                 295                 300                 


Ser Tyr Ile Glu Glu Val Ala Lys Ala Tyr Glu Lys Glu Ala Gly Val 
305                 310                 315                 320 


Lys Val Thr Leu Lys Thr Gly Asp Ala Leu Gly Gly Leu Asp Lys Leu 
                325                 330                 335     


Ser Leu Asp Asn Gln Ser Gly Asn Val Pro Asp Val Met Met Ala Pro 
            340                 345                 350         


Tyr Asp Arg Val Gly Ser Leu Gly Ser Asp Gly Gln Leu Ser Glu Val 
        355                 360                 365             


Lys Leu Ser Asp Gly Ala Lys Thr Asp Asp Thr Thr Lys Ser Leu Val 
    370                 375                 380                 


Thr Ala Ala Asn Gly Lys Val Tyr Gly Ala Pro Ala Val Ile Glu Ser 
385                 390                 395                 400 


Leu Val Met Tyr Tyr Asn Lys Asp Leu Val Lys Asp Ala Pro Lys Thr 
                405                 410                 415     


Phe Ala Asp Leu Glu Asn Leu Ala Lys Asp Ser Lys Tyr Ala Phe Ala 
            420                 425                 430         


Gly Glu Asp Gly Lys Thr Thr Ala Phe Leu Ala Asp Trp Thr Asn Phe 
        435                 440                 445             


Tyr Tyr Thr Tyr Gly Leu Leu Ala Gly Asn Gly Ala Tyr Val Phe Gly 
    450                 455                 460                 


Gln Asn Gly Lys Asp Ala Lys Asp Ile Gly Leu Ala Asn Asp Gly Ser 
465                 470                 475                 480 


Ile Val Gly Ile Asn Tyr Ala Lys Ser Trp Tyr Glu Lys Trp Pro Lys 
                485                 490                 495     


Gly Met Gln Asp Thr Glu Gly Ala Gly Asn Leu Ile Gln Thr Gln Phe 
            500                 505                 510         


Gln Glu Gly Lys Thr Ala Ala Ile Ile Asp Gly Pro Trp Lys Ala Gln 
        515                 520                 525             


Ala Phe Lys Asp Ala Lys Val Asn Tyr Gly Val Ala Thr Ile Pro Thr 
    530                 535                 540                 


Leu Pro Asn Gly Lys Glu Tyr Ala Ala Phe Gly Gly Gly Lys Ala Trp 
545                 550                 555                 560 


Val Ile Pro Gln Ala Val Lys Asn Leu Glu Ala Ser Gln Lys Phe Val 
                565                 570                 575     


Asp Phe Leu Val Ala Thr Glu Gln Gln Lys Val Leu Tyr Asp Lys Thr 
            580                 585                 590         


Asn Glu Ile Pro Ala Asn Thr Glu Ala Arg Ser Tyr Ala Glu Gly Lys 
        595                 600                 605             


Asn Asp Glu Leu Thr Thr Ala Val Ile Lys Gln Phe Lys Asn Thr Gln 
    610                 615                 620                 


Pro Leu Pro Asn Ile Ser Gln Met Ser Ala Val Trp Asp Pro Ala Lys 
625                 630                 635                 640 


Asn Met Leu Phe Asp Ala Val Ser Gly Gln Lys Asp Ala Lys Thr Ala 
                645                 650                 655     


Ala Asn Asp Ala Val Thr Leu Ile Lys Glu Thr Ile Lys Gln Lys Phe 
            660                 665                 670         


Gly Glu Asn Gly Met Lys Ala Lys Lys Met Trp Met Ala Gly Leu Ala 
        675                 680                 685             


Leu Leu Gly Ile Gly Ser Leu Ala Leu Ala Thr Lys Lys Val Ala Asp 
    690                 695                 700                 


Asp Arg Lys Leu Met Lys Thr Gln Glu Glu Leu Thr Glu Ile Val Arg 
705                 710                 715                 720 


Asp His Phe Ser Asp Met Gly Glu Ile Ala Thr Leu Tyr Val Gln Val 
                725                 730                 735     


Tyr Glu Ser Ser Leu Glu Ser Leu Val Gly Gly Val Ile Phe Glu Asp 
            740                 745                 750         


Gly Arg His Tyr Thr Phe Val Tyr Glu Asn Glu Asp Leu Val Tyr Glu 
        755                 760                 765             


Glu Glu Val Leu 
    770         


<210>  55
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP0148/CD2

<400>  55

Met Lys Lys Ile Val Lys Tyr Ser Ser Leu Ala Ala Leu Ala Leu Val 
1               5                   10                  15      


Ala Ala Gly Val Leu Ala Ala Cys Ser Gly Gly Ala Lys Lys Glu Gly 
            20                  25                  30          


Glu Ala Ala Ser Lys Lys Glu Ile Ile Val Ala Thr Asn Gly Ser Pro 
        35                  40                  45              


Lys Pro Phe Ile Tyr Glu Glu Asn Gly Glu Leu Thr Gly Tyr Glu Ile 
    50                  55                  60                  


Glu Val Val Arg Ala Ile Phe Lys Asp Ser Asp Lys Tyr Asp Val Lys 
65                  70                  75                  80  


Phe Glu Lys Thr Glu Trp Ser Gly Val Phe Ala Gly Leu Asp Ala Asp 
                85                  90                  95      


Arg Tyr Asn Met Ala Val Asn Asn Leu Ser Tyr Thr Lys Glu Arg Ala 
            100                 105                 110         


Glu Lys Tyr Leu Tyr Ala Ala Pro Ile Ala Gln Asn Pro Asn Val Leu 
        115                 120                 125             


Val Val Lys Lys Asp Asp Ser Ser Ile Lys Ser Leu Asp Asp Ile Gly 
    130                 135                 140                 


Gly Lys Ser Thr Glu Val Val Gln Ala Thr Thr Ser Ala Lys Gln Leu 
145                 150                 155                 160 


Glu Ala Tyr Asn Ala Glu His Thr Asp Asn Pro Thr Ile Leu Asn Tyr 
                165                 170                 175     


Thr Lys Ala Asp Phe Gln Gln Ile Met Val Arg Leu Ser Asp Gly Gln 
            180                 185                 190         


Phe Asp Tyr Lys Ile Phe Asp Lys Ile Gly Val Glu Thr Val Ile Lys 
        195                 200                 205             


Asn Gln Gly Leu Asp Asn Leu Lys Val Ile Glu Leu Pro Ser Asp Gln 
    210                 215                 220                 


Gln Pro Tyr Val Tyr Pro Leu Leu Ala Gln Gly Gln Asp Glu Leu Lys 
225                 230                 235                 240 


Ser Phe Val Asp Lys Arg Ile Lys Glu Leu Tyr Lys Asp Gly Thr Leu 
                245                 250                 255     


Glu Lys Leu Ser Lys Gln Phe Phe Gly Asp Thr Tyr Leu Pro Ala Glu 
            260                 265                 270         


Ala Asp Ile Lys Met Ala Met Ala Asp Leu Lys Lys Ala Val Asn Glu 
        275                 280                 285             


Pro Glu Lys Pro Ala Glu Glu Glu Pro Glu Asn Pro Ala Pro Ala Pro 
    290                 295                 300                 


Lys Pro Ala Pro Ala Pro Gln Pro Glu Lys Pro Ala Pro Ala Pro Ala 
305                 310                 315                 320 


Pro Lys Pro Glu Lys Ser Ala Asp Gln Gln Ala Glu Glu Asp Tyr Ala 
                325                 330                 335     


Arg Arg Ser Glu Glu Glu Tyr Asn Arg Leu Thr Gln Gln Gln Pro Pro 
            340                 345                 350         


Lys Ala Glu Lys Pro Ala Pro Ala Pro Val Pro Lys Pro Glu Gln Pro 
        355                 360                 365             


Ala Pro Ala Pro Lys Thr Gly Trp Lys Gln Glu Asn Gly Met Trp His 
    370                 375                 380                 


His His His His His 
385                 


<210>  56
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP0148/H70

<400>  56

Met Lys Lys Ile Val Lys Tyr Ser Ser Leu Ala Ala Leu Ala Leu Val 
1               5                   10                  15      


Ala Ala Gly Val Leu Ala Ala Cys Ser Gly Gly Ala Lys Lys Glu Gly 
            20                  25                  30          


Glu Ala Ala Ser Lys Lys Glu Ile Ile Val Ala Thr Asn Gly Ser Pro 
        35                  40                  45              


Lys Pro Phe Ile Tyr Glu Glu Asn Gly Glu Leu Thr Gly Tyr Glu Ile 
    50                  55                  60                  


Glu Val Val Arg Ala Ile Phe Lys Asp Ser Asp Lys Tyr Asp Val Lys 
65                  70                  75                  80  


Phe Glu Lys Thr Glu Trp Ser Gly Val Phe Ala Gly Leu Asp Ala Asp 
                85                  90                  95      


Arg Tyr Asn Met Ala Val Asn Asn Leu Ser Tyr Thr Lys Glu Arg Ala 
            100                 105                 110         


Glu Lys Tyr Leu Tyr Ala Ala Pro Ile Ala Gln Asn Pro Asn Val Leu 
        115                 120                 125             


Val Val Lys Lys Asp Asp Ser Ser Ile Lys Ser Leu Asp Asp Ile Gly 
    130                 135                 140                 


Gly Lys Ser Thr Glu Val Val Gln Ala Thr Thr Ser Ala Lys Gln Leu 
145                 150                 155                 160 


Glu Ala Tyr Asn Ala Glu His Thr Asp Asn Pro Thr Ile Leu Asn Tyr 
                165                 170                 175     


Thr Lys Ala Asp Phe Gln Gln Ile Met Val Arg Leu Ser Asp Gly Gln 
            180                 185                 190         


Phe Asp Tyr Lys Ile Phe Asp Lys Ile Gly Val Glu Thr Val Ile Lys 
        195                 200                 205             


Asn Gln Gly Leu Asp Asn Leu Lys Val Ile Glu Leu Pro Ser Asp Gln 
    210                 215                 220                 


Gln Pro Tyr Val Tyr Pro Leu Leu Ala Gln Gly Gln Asp Glu Leu Lys 
225                 230                 235                 240 


Ser Phe Val Asp Lys Arg Ile Lys Glu Leu Tyr Lys Asp Gly Thr Leu 
                245                 250                 255     


Glu Lys Leu Ser Lys Gln Phe Phe Gly Asp Thr Tyr Leu Pro Ala Glu 
            260                 265                 270         


Ala Asp Ile Lys Tyr Phe Lys Glu Gly Leu Glu Lys Thr Ile Ala Ala 
        275                 280                 285             


Lys Lys Ala Glu Leu Glu Lys Thr Glu Ala Asp Leu Lys Lys Ala Val 
    290                 295                 300                 


Asn Glu Pro Glu Lys Pro Ala Pro Ala Pro Glu Thr Pro Ala Pro Glu 
305                 310                 315                 320 


Ala Pro Ala Glu Gln Pro Lys Pro Ala Pro Ala Pro Gln Pro Ala Pro 
                325                 330                 335     


Ala Pro Lys Pro Glu Lys Pro Ala Glu Gln Pro Lys Pro Glu Lys Thr 
            340                 345                 350         


Asp Asp Gln Gln Ala Glu Glu Asp Tyr Ala Arg Arg Ser Glu Glu Glu 
        355                 360                 365             


Tyr Asn Arg Leu Thr Gln Gln Gln Pro Pro Lys Ala Glu Lys Pro Ala 
    370                 375                 380                 


Pro Ala Pro Lys Thr Gly Trp Lys Gln Glu Asn Gly Met Trp His His 
385                 390                 395                 400 


His His His His 
                


<210>  57
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP2108/CD2

<400>  57

Met Ser Ser Lys Phe Met Lys Ser Ala Ala Val Leu Gly Thr Ala Thr 
1               5                   10                  15      


Leu Ala Ser Leu Leu Leu Val Ala Cys Gly Ser Lys Thr Ala Asp Lys 
            20                  25                  30          


Pro Ala Asp Ser Gly Ser Ser Glu Val Lys Glu Leu Thr Val Tyr Val 
        35                  40                  45              


Asp Glu Gly Tyr Lys Ser Tyr Ile Glu Glu Val Ala Lys Ala Tyr Glu 
    50                  55                  60                  


Lys Glu Ala Gly Val Lys Val Thr Leu Lys Thr Gly Asp Ala Leu Gly 
65                  70                  75                  80  


Gly Leu Asp Lys Leu Ser Leu Asp Asn Gln Ser Gly Asn Val Pro Asp 
                85                  90                  95      


Val Met Met Ala Pro Tyr Asp Arg Val Gly Ser Leu Gly Ser Asp Gly 
            100                 105                 110         


Gln Leu Ser Glu Val Lys Leu Ser Asp Gly Ala Lys Thr Asp Asp Thr 
        115                 120                 125             


Thr Lys Ser Leu Val Thr Ala Ala Asn Gly Lys Val Tyr Gly Ala Pro 
    130                 135                 140                 


Ala Val Ile Glu Ser Leu Val Met Tyr Tyr Asn Lys Asp Leu Val Lys 
145                 150                 155                 160 


Asp Ala Pro Lys Thr Phe Ala Asp Leu Glu Asn Leu Ala Lys Asp Ser 
                165                 170                 175     


Lys Tyr Ala Phe Ala Gly Glu Asp Gly Lys Thr Thr Ala Phe Leu Ala 
            180                 185                 190         


Asp Trp Thr Asn Phe Tyr Tyr Thr Tyr Gly Leu Leu Ala Gly Asn Gly 
        195                 200                 205             


Ala Tyr Val Phe Gly Gln Asn Gly Lys Asp Ala Lys Asp Ile Gly Leu 
    210                 215                 220                 


Ala Asn Asp Gly Ser Ile Val Gly Ile Asn Tyr Ala Lys Ser Trp Tyr 
225                 230                 235                 240 


Glu Lys Trp Pro Lys Gly Met Gln Asp Thr Glu Gly Ala Gly Asn Leu 
                245                 250                 255     


Ile Gln Thr Gln Phe Gln Glu Gly Lys Thr Ala Ala Ile Ile Asp Gly 
            260                 265                 270         


Pro Trp Lys Ala Gln Ala Phe Lys Asp Ala Lys Val Asn Tyr Gly Val 
        275                 280                 285             


Ala Thr Ile Pro Thr Leu Pro Asn Gly Lys Glu Tyr Ala Ala Phe Gly 
    290                 295                 300                 


Gly Gly Lys Ala Trp Val Ile Pro Gln Ala Val Lys Asn Leu Glu Ala 
305                 310                 315                 320 


Ser Gln Lys Phe Val Asp Phe Leu Val Ala Thr Glu Gln Gln Lys Val 
                325                 330                 335     


Leu Tyr Asp Lys Thr Asn Glu Ile Pro Ala Asn Thr Glu Ala Arg Ser 
            340                 345                 350         


Tyr Ala Glu Gly Lys Asn Asp Glu Leu Thr Thr Ala Val Ile Lys Gln 
        355                 360                 365             


Phe Lys Asn Thr Gln Pro Leu Pro Asn Ile Ser Gln Met Ser Ala Val 
    370                 375                 380                 


Trp Asp Pro Ala Lys Asn Met Leu Phe Asp Ala Val Ser Gly Gln Lys 
385                 390                 395                 400 


Asp Ala Lys Thr Ala Ala Asn Asp Ala Val Thr Leu Ile Lys Glu Thr 
                405                 410                 415     


Ile Lys Gln Lys Phe Gly Glu Met Ala Met Ala Asp Leu Lys Lys Ala 
            420                 425                 430         


Val Asn Glu Pro Glu Lys Pro Ala Glu Glu Glu Pro Glu Asn Pro Ala 
        435                 440                 445             


Pro Ala Pro Lys Pro Ala Pro Ala Pro Gln Pro Glu Lys Pro Ala Pro 
    450                 455                 460                 


Ala Pro Ala Pro Lys Pro Glu Lys Ser Ala Asp Gln Gln Ala Glu Glu 
465                 470                 475                 480 


Asp Tyr Ala Arg Arg Ser Glu Glu Glu Tyr Asn Arg Leu Thr Gln Gln 
                485                 490                 495     


Gln Pro Pro Lys Ala Glu Lys Pro Ala Pro Ala Pro Val Pro Lys Pro 
            500                 505                 510         


Glu Gln Pro Ala Pro Ala Pro Lys Thr Gly Trp Lys Gln Glu Asn Gly 
        515                 520                 525             


Met Trp His His His His His His 
    530                 535     


<210>  58
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP2108/H70

<400>  58

Met Ser Ser Lys Phe Met Lys Ser Ala Ala Val Leu Gly Thr Ala Thr 
1               5                   10                  15      


Leu Ala Ser Leu Leu Leu Val Ala Cys Gly Ser Lys Thr Ala Asp Lys 
            20                  25                  30          


Pro Ala Asp Ser Gly Ser Ser Glu Val Lys Glu Leu Thr Val Tyr Val 
        35                  40                  45              


Asp Glu Gly Tyr Lys Ser Tyr Ile Glu Glu Val Ala Lys Ala Tyr Glu 
    50                  55                  60                  


Lys Glu Ala Gly Val Lys Val Thr Leu Lys Thr Gly Asp Ala Leu Gly 
65                  70                  75                  80  


Gly Leu Asp Lys Leu Ser Leu Asp Asn Gln Ser Gly Asn Val Pro Asp 
                85                  90                  95      


Val Met Met Ala Pro Tyr Asp Arg Val Gly Ser Leu Gly Ser Asp Gly 
            100                 105                 110         


Gln Leu Ser Glu Val Lys Leu Ser Asp Gly Ala Lys Thr Asp Asp Thr 
        115                 120                 125             


Thr Lys Ser Leu Val Thr Ala Ala Asn Gly Lys Val Tyr Gly Ala Pro 
    130                 135                 140                 


Ala Val Ile Glu Ser Leu Val Met Tyr Tyr Asn Lys Asp Leu Val Lys 
145                 150                 155                 160 


Asp Ala Pro Lys Thr Phe Ala Asp Leu Glu Asn Leu Ala Lys Asp Ser 
                165                 170                 175     


Lys Tyr Ala Phe Ala Gly Glu Asp Gly Lys Thr Thr Ala Phe Leu Ala 
            180                 185                 190         


Asp Trp Thr Asn Phe Tyr Tyr Thr Tyr Gly Leu Leu Ala Gly Asn Gly 
        195                 200                 205             


Ala Tyr Val Phe Gly Gln Asn Gly Lys Asp Ala Lys Asp Ile Gly Leu 
    210                 215                 220                 


Ala Asn Asp Gly Ser Ile Val Gly Ile Asn Tyr Ala Lys Ser Trp Tyr 
225                 230                 235                 240 


Glu Lys Trp Pro Lys Gly Met Gln Asp Thr Glu Gly Ala Gly Asn Leu 
                245                 250                 255     


Ile Gln Thr Gln Phe Gln Glu Gly Lys Thr Ala Ala Ile Ile Asp Gly 
            260                 265                 270         


Pro Trp Lys Ala Gln Ala Phe Lys Asp Ala Lys Val Asn Tyr Gly Val 
        275                 280                 285             


Ala Thr Ile Pro Thr Leu Pro Asn Gly Lys Glu Tyr Ala Ala Phe Gly 
    290                 295                 300                 


Gly Gly Lys Ala Trp Val Ile Pro Gln Ala Val Lys Asn Leu Glu Ala 
305                 310                 315                 320 


Ser Gln Lys Phe Val Asp Phe Leu Val Ala Thr Glu Gln Gln Lys Val 
                325                 330                 335     


Leu Tyr Asp Lys Thr Asn Glu Ile Pro Ala Asn Thr Glu Ala Arg Ser 
            340                 345                 350         


Tyr Ala Glu Gly Lys Asn Asp Glu Leu Thr Thr Ala Val Ile Lys Gln 
        355                 360                 365             


Phe Lys Asn Thr Gln Pro Leu Pro Asn Ile Ser Gln Met Ser Ala Val 
    370                 375                 380                 


Trp Asp Pro Ala Lys Asn Met Leu Phe Asp Ala Val Ser Gly Gln Lys 
385                 390                 395                 400 


Asp Ala Lys Thr Ala Ala Asn Asp Ala Val Thr Leu Ile Lys Glu Thr 
                405                 410                 415     


Ile Lys Gln Lys Phe Gly Glu Tyr Phe Lys Glu Gly Leu Glu Lys Thr 
            420                 425                 430         


Ile Ala Ala Lys Lys Ala Glu Leu Glu Lys Thr Glu Ala Asp Leu Lys 
        435                 440                 445             


Lys Ala Val Asn Glu Pro Glu Lys Pro Ala Pro Ala Pro Glu Thr Pro 
    450                 455                 460                 


Ala Pro Glu Ala Pro Ala Glu Gln Pro Lys Pro Ala Pro Ala Pro Gln 
465                 470                 475                 480 


Pro Ala Pro Ala Pro Lys Pro Glu Lys Pro Ala Glu Gln Pro Lys Pro 
                485                 490                 495     


Glu Lys Thr Asp Asp Gln Gln Ala Glu Glu Asp Tyr Ala Arg Arg Ser 
            500                 505                 510         


Glu Glu Glu Tyr Asn Arg Leu Thr Gln Gln Gln Pro Pro Lys Ala Glu 
        515                 520                 525             


Lys Pro Ala Pro Ala Pro Lys Thr Gly Trp Lys Gln Glu Asn Gly Met 
    530                 535                 540                 


Trp His His His His His His 
545                 550     


<210>  59
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP0148/LC/CD2

<400>  59

Met Lys Lys Ile Val Lys Tyr Ser Ser Leu Ala Ala Leu Ala Leu Val 
1               5                   10                  15      


Ala Ala Gly Val Leu Ala Ala Cys Ser Gly Gly Ala Lys Lys Glu Gly 
            20                  25                  30          


Glu Ala Ala Ser Lys Lys Glu Ile Ile Val Ala Thr Asn Gly Ser Pro 
        35                  40                  45              


Lys Pro Phe Ile Tyr Glu Glu Asn Gly Glu Leu Thr Gly Tyr Glu Ile 
    50                  55                  60                  


Glu Val Val Arg Ala Ile Phe Lys Asp Ser Asp Lys Tyr Asp Val Lys 
65                  70                  75                  80  


Phe Glu Lys Thr Glu Trp Ser Gly Val Phe Ala Gly Leu Asp Ala Asp 
                85                  90                  95      


Arg Tyr Asn Met Ala Val Asn Asn Leu Ser Tyr Thr Lys Glu Arg Ala 
            100                 105                 110         


Glu Lys Tyr Leu Tyr Ala Ala Pro Ile Ala Gln Asn Pro Asn Val Leu 
        115                 120                 125             


Val Val Lys Lys Asp Asp Ser Ser Ile Lys Ser Leu Asp Asp Ile Gly 
    130                 135                 140                 


Gly Lys Ser Thr Glu Val Val Gln Ala Thr Thr Ser Ala Lys Gln Leu 
145                 150                 155                 160 


Glu Ala Tyr Asn Ala Glu His Thr Asp Asn Pro Thr Ile Leu Asn Tyr 
                165                 170                 175     


Thr Lys Ala Asp Phe Gln Gln Ile Met Val Arg Leu Ser Asp Gly Gln 
            180                 185                 190         


Phe Asp Tyr Lys Ile Phe Asp Lys Ile Gly Val Glu Thr Val Ile Lys 
        195                 200                 205             


Asn Gln Gly Leu Asp Asn Leu Lys Val Ile Glu Leu Pro Ser Asp Gln 
    210                 215                 220                 


Gln Pro Tyr Val Tyr Pro Leu Leu Ala Gln Gly Gln Asp Glu Leu Lys 
225                 230                 235                 240 


Ser Phe Val Asp Lys Arg Ile Lys Glu Leu Tyr Lys Asp Gly Thr Leu 
                245                 250                 255     


Glu Lys Leu Ser Lys Gln Phe Phe Gly Asp Thr Tyr Leu Pro Ala Glu 
            260                 265                 270         


Ala Asp Ile Lys Gly Pro Lys Pro His Arg Ile Gln Ser Thr Pro Lys 
        275                 280                 285             


Gly Ser Met Ala Met Ala Asp Leu Lys Lys Ala Val Asn Glu Pro Glu 
    290                 295                 300                 


Lys Pro Ala Glu Glu Glu Pro Glu Asn Pro Ala Pro Ala Pro Lys Pro 
305                 310                 315                 320 


Ala Pro Ala Pro Gln Pro Glu Lys Pro Ala Pro Ala Pro Ala Pro Lys 
                325                 330                 335     


Pro Glu Lys Ser Ala Asp Gln Gln Ala Glu Glu Asp Tyr Ala Arg Arg 
            340                 345                 350         


Ser Glu Glu Glu Tyr Asn Arg Leu Thr Gln Gln Gln Pro Pro Lys Ala 
        355                 360                 365             


Glu Lys Pro Ala Pro Ala Pro Val Pro Lys Pro Glu Gln Pro Ala Pro 
    370                 375                 380                 


Ala Pro Lys Thr Gly Trp Lys Gln Glu Asn Gly Met Trp His His His 
385                 390                 395                 400 


His His His 
            


<210>  60
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP0148/LC/H70

<400>  60

Met Lys Lys Ile Val Lys Tyr Ser Ser Leu Ala Ala Leu Ala Leu Val 
1               5                   10                  15      


Ala Ala Gly Val Leu Ala Ala Cys Ser Gly Gly Ala Lys Lys Glu Gly 
            20                  25                  30          


Glu Ala Ala Ser Lys Lys Glu Ile Ile Val Ala Thr Asn Gly Ser Pro 
        35                  40                  45              


Lys Pro Phe Ile Tyr Glu Glu Asn Gly Glu Leu Thr Gly Tyr Glu Ile 
    50                  55                  60                  


Glu Val Val Arg Ala Ile Phe Lys Asp Ser Asp Lys Tyr Asp Val Lys 
65                  70                  75                  80  


Phe Glu Lys Thr Glu Trp Ser Gly Val Phe Ala Gly Leu Asp Ala Asp 
                85                  90                  95      


Arg Tyr Asn Met Ala Val Asn Asn Leu Ser Tyr Thr Lys Glu Arg Ala 
            100                 105                 110         


Glu Lys Tyr Leu Tyr Ala Ala Pro Ile Ala Gln Asn Pro Asn Val Leu 
        115                 120                 125             


Val Val Lys Lys Asp Asp Ser Ser Ile Lys Ser Leu Asp Asp Ile Gly 
    130                 135                 140                 


Gly Lys Ser Thr Glu Val Val Gln Ala Thr Thr Ser Ala Lys Gln Leu 
145                 150                 155                 160 


Glu Ala Tyr Asn Ala Glu His Thr Asp Asn Pro Thr Ile Leu Asn Tyr 
                165                 170                 175     


Thr Lys Ala Asp Phe Gln Gln Ile Met Val Arg Leu Ser Asp Gly Gln 
            180                 185                 190         


Phe Asp Tyr Lys Ile Phe Asp Lys Ile Gly Val Glu Thr Val Ile Lys 
        195                 200                 205             


Asn Gln Gly Leu Asp Asn Leu Lys Val Ile Glu Leu Pro Ser Asp Gln 
    210                 215                 220                 


Gln Pro Tyr Val Tyr Pro Leu Leu Ala Gln Gly Gln Asp Glu Leu Lys 
225                 230                 235                 240 


Ser Phe Val Asp Lys Arg Ile Lys Glu Leu Tyr Lys Asp Gly Thr Leu 
                245                 250                 255     


Glu Lys Leu Ser Lys Gln Phe Phe Gly Asp Thr Tyr Leu Pro Ala Glu 
            260                 265                 270         


Ala Asp Ile Lys Gly Pro Lys Pro His Arg Ile Gln Ser Thr Pro Lys 
        275                 280                 285             


Gly Ser Tyr Phe Lys Glu Gly Leu Glu Lys Thr Ile Ala Ala Lys Lys 
    290                 295                 300                 


Ala Glu Leu Glu Lys Thr Glu Ala Asp Leu Lys Lys Ala Val Asn Glu 
305                 310                 315                 320 


Pro Glu Lys Pro Ala Pro Ala Pro Glu Thr Pro Ala Pro Glu Ala Pro 
                325                 330                 335     


Ala Glu Gln Pro Lys Pro Ala Pro Ala Pro Gln Pro Ala Pro Ala Pro 
            340                 345                 350         


Lys Pro Glu Lys Pro Ala Glu Gln Pro Lys Pro Glu Lys Thr Asp Asp 
        355                 360                 365             


Gln Gln Ala Glu Glu Asp Tyr Ala Arg Arg Ser Glu Glu Glu Tyr Asn 
    370                 375                 380                 


Arg Leu Thr Gln Gln Gln Pro Pro Lys Ala Glu Lys Pro Ala Pro Ala 
385                 390                 395                 400 


Pro Lys Thr Gly Trp Lys Gln Glu Asn Gly Met Trp His His His His 
                405                 410                 415     


His His 
        


<210>  61
<211>  550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP2108/LC/CD2

<400>  61

Met Ser Ser Lys Phe Met Lys Ser Ala Ala Val Leu Gly Thr Ala Thr 
1               5                   10                  15      


Leu Ala Ser Leu Leu Leu Val Ala Cys Gly Ser Lys Thr Ala Asp Lys 
            20                  25                  30          


Pro Ala Asp Ser Gly Ser Ser Glu Val Lys Glu Leu Thr Val Tyr Val 
        35                  40                  45              


Asp Glu Gly Tyr Lys Ser Tyr Ile Glu Glu Val Ala Lys Ala Tyr Glu 
    50                  55                  60                  


Lys Glu Ala Gly Val Lys Val Thr Leu Lys Thr Gly Asp Ala Leu Gly 
65                  70                  75                  80  


Gly Leu Asp Lys Leu Ser Leu Asp Asn Gln Ser Gly Asn Val Pro Asp 
                85                  90                  95      


Val Met Met Ala Pro Tyr Asp Arg Val Gly Ser Leu Gly Ser Asp Gly 
            100                 105                 110         


Gln Leu Ser Glu Val Lys Leu Ser Asp Gly Ala Lys Thr Asp Asp Thr 
        115                 120                 125             


Thr Lys Ser Leu Val Thr Ala Ala Asn Gly Lys Val Tyr Gly Ala Pro 
    130                 135                 140                 


Ala Val Ile Glu Ser Leu Val Met Tyr Tyr Asn Lys Asp Leu Val Lys 
145                 150                 155                 160 


Asp Ala Pro Lys Thr Phe Ala Asp Leu Glu Asn Leu Ala Lys Asp Ser 
                165                 170                 175     


Lys Tyr Ala Phe Ala Gly Glu Asp Gly Lys Thr Thr Ala Phe Leu Ala 
            180                 185                 190         


Asp Trp Thr Asn Phe Tyr Tyr Thr Tyr Gly Leu Leu Ala Gly Asn Gly 
        195                 200                 205             


Ala Tyr Val Phe Gly Gln Asn Gly Lys Asp Ala Lys Asp Ile Gly Leu 
    210                 215                 220                 


Ala Asn Asp Gly Ser Ile Val Gly Ile Asn Tyr Ala Lys Ser Trp Tyr 
225                 230                 235                 240 


Glu Lys Trp Pro Lys Gly Met Gln Asp Thr Glu Gly Ala Gly Asn Leu 
                245                 250                 255     


Ile Gln Thr Gln Phe Gln Glu Gly Lys Thr Ala Ala Ile Ile Asp Gly 
            260                 265                 270         


Pro Trp Lys Ala Gln Ala Phe Lys Asp Ala Lys Val Asn Tyr Gly Val 
        275                 280                 285             


Ala Thr Ile Pro Thr Leu Pro Asn Gly Lys Glu Tyr Ala Ala Phe Gly 
    290                 295                 300                 


Gly Gly Lys Ala Trp Val Ile Pro Gln Ala Val Lys Asn Leu Glu Ala 
305                 310                 315                 320 


Ser Gln Lys Phe Val Asp Phe Leu Val Ala Thr Glu Gln Gln Lys Val 
                325                 330                 335     


Leu Tyr Asp Lys Thr Asn Glu Ile Pro Ala Asn Thr Glu Ala Arg Ser 
            340                 345                 350         


Tyr Ala Glu Gly Lys Asn Asp Glu Leu Thr Thr Ala Val Ile Lys Gln 
        355                 360                 365             


Phe Lys Asn Thr Gln Pro Leu Pro Asn Ile Ser Gln Met Ser Ala Val 
    370                 375                 380                 


Trp Asp Pro Ala Lys Asn Met Leu Phe Asp Ala Val Ser Gly Gln Lys 
385                 390                 395                 400 


Asp Ala Lys Thr Ala Ala Asn Asp Ala Val Thr Leu Ile Lys Glu Thr 
                405                 410                 415     


Ile Lys Gln Lys Phe Gly Glu Gly Pro Lys Pro His Arg Ile Gln Ser 
            420                 425                 430         


Thr Pro Lys Gly Ser Met Ala Met Ala Asp Leu Lys Lys Ala Val Asn 
        435                 440                 445             


Glu Pro Glu Lys Pro Ala Glu Glu Glu Pro Glu Asn Pro Ala Pro Ala 
    450                 455                 460                 


Pro Lys Pro Ala Pro Ala Pro Gln Pro Glu Lys Pro Ala Pro Ala Pro 
465                 470                 475                 480 


Ala Pro Lys Pro Glu Lys Ser Ala Asp Gln Gln Ala Glu Glu Asp Tyr 
                485                 490                 495     


Ala Arg Arg Ser Glu Glu Glu Tyr Asn Arg Leu Thr Gln Gln Gln Pro 
            500                 505                 510         


Pro Lys Ala Glu Lys Pro Ala Pro Ala Pro Val Pro Lys Pro Glu Gln 
        515                 520                 525             


Pro Ala Pro Ala Pro Lys Thr Gly Trp Lys Gln Glu Asn Gly Met Trp 
    530                 535                 540                 


His His His His His His 
545                 550 


<210>  62
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP2108/LC/H70

<400>  62

Met Ser Ser Lys Phe Met Lys Ser Ala Ala Val Leu Gly Thr Ala Thr 
1               5                   10                  15      


Leu Ala Ser Leu Leu Leu Val Ala Cys Gly Ser Lys Thr Ala Asp Lys 
            20                  25                  30          


Pro Ala Asp Ser Gly Ser Ser Glu Val Lys Glu Leu Thr Val Tyr Val 
        35                  40                  45              


Asp Glu Gly Tyr Lys Ser Tyr Ile Glu Glu Val Ala Lys Ala Tyr Glu 
    50                  55                  60                  


Lys Glu Ala Gly Val Lys Val Thr Leu Lys Thr Gly Asp Ala Leu Gly 
65                  70                  75                  80  


Gly Leu Asp Lys Leu Ser Leu Asp Asn Gln Ser Gly Asn Val Pro Asp 
                85                  90                  95      


Val Met Met Ala Pro Tyr Asp Arg Val Gly Ser Leu Gly Ser Asp Gly 
            100                 105                 110         


Gln Leu Ser Glu Val Lys Leu Ser Asp Gly Ala Lys Thr Asp Asp Thr 
        115                 120                 125             


Thr Lys Ser Leu Val Thr Ala Ala Asn Gly Lys Val Tyr Gly Ala Pro 
    130                 135                 140                 


Ala Val Ile Glu Ser Leu Val Met Tyr Tyr Asn Lys Asp Leu Val Lys 
145                 150                 155                 160 


Asp Ala Pro Lys Thr Phe Ala Asp Leu Glu Asn Leu Ala Lys Asp Ser 
                165                 170                 175     


Lys Tyr Ala Phe Ala Gly Glu Asp Gly Lys Thr Thr Ala Phe Leu Ala 
            180                 185                 190         


Asp Trp Thr Asn Phe Tyr Tyr Thr Tyr Gly Leu Leu Ala Gly Asn Gly 
        195                 200                 205             


Ala Tyr Val Phe Gly Gln Asn Gly Lys Asp Ala Lys Asp Ile Gly Leu 
    210                 215                 220                 


Ala Asn Asp Gly Ser Ile Val Gly Ile Asn Tyr Ala Lys Ser Trp Tyr 
225                 230                 235                 240 


Glu Lys Trp Pro Lys Gly Met Gln Asp Thr Glu Gly Ala Gly Asn Leu 
                245                 250                 255     


Ile Gln Thr Gln Phe Gln Glu Gly Lys Thr Ala Ala Ile Ile Asp Gly 
            260                 265                 270         


Pro Trp Lys Ala Gln Ala Phe Lys Asp Ala Lys Val Asn Tyr Gly Val 
        275                 280                 285             


Ala Thr Ile Pro Thr Leu Pro Asn Gly Lys Glu Tyr Ala Ala Phe Gly 
    290                 295                 300                 


Gly Gly Lys Ala Trp Val Ile Pro Gln Ala Val Lys Asn Leu Glu Ala 
305                 310                 315                 320 


Ser Gln Lys Phe Val Asp Phe Leu Val Ala Thr Glu Gln Gln Lys Val 
                325                 330                 335     


Leu Tyr Asp Lys Thr Asn Glu Ile Pro Ala Asn Thr Glu Ala Arg Ser 
            340                 345                 350         


Tyr Ala Glu Gly Lys Asn Asp Glu Leu Thr Thr Ala Val Ile Lys Gln 
        355                 360                 365             


Phe Lys Asn Thr Gln Pro Leu Pro Asn Ile Ser Gln Met Ser Ala Val 
    370                 375                 380                 


Trp Asp Pro Ala Lys Asn Met Leu Phe Asp Ala Val Ser Gly Gln Lys 
385                 390                 395                 400 


Asp Ala Lys Thr Ala Ala Asn Asp Ala Val Thr Leu Ile Lys Glu Thr 
                405                 410                 415     


Ile Lys Gln Lys Phe Gly Glu Gly Pro Lys Pro His Arg Ile Gln Ser 
            420                 425                 430         


Thr Pro Lys Gly Ser Tyr Phe Lys Glu Gly Leu Glu Lys Thr Ile Ala 
        435                 440                 445             


Ala Lys Lys Ala Glu Leu Glu Lys Thr Glu Ala Asp Leu Lys Lys Ala 
    450                 455                 460                 


Val Asn Glu Pro Glu Lys Pro Ala Pro Ala Pro Glu Thr Pro Ala Pro 
465                 470                 475                 480 


Glu Ala Pro Ala Glu Gln Pro Lys Pro Ala Pro Ala Pro Gln Pro Ala 
                485                 490                 495     


Pro Ala Pro Lys Pro Glu Lys Pro Ala Glu Gln Pro Lys Pro Glu Lys 
            500                 505                 510         


Thr Asp Asp Gln Gln Ala Glu Glu Asp Tyr Ala Arg Arg Ser Glu Glu 
        515                 520                 525             


Glu Tyr Asn Arg Leu Thr Gln Gln Gln Pro Pro Lys Ala Glu Lys Pro 
    530                 535                 540                 


Ala Pro Ala Pro Lys Thr Gly Trp Lys Gln Glu Asn Gly Met Trp His 
545                 550                 555                 560 


His His His His His 
                565 


<210>  63
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP0148/LR/CD2

<400>  63

Met Lys Lys Ile Val Lys Tyr Ser Ser Leu Ala Ala Leu Ala Leu Val 
1               5                   10                  15      


Ala Ala Gly Val Leu Ala Ala Cys Ser Gly Gly Ala Lys Lys Glu Gly 
            20                  25                  30          


Glu Ala Ala Ser Lys Lys Glu Ile Ile Val Ala Thr Asn Gly Ser Pro 
        35                  40                  45              


Lys Pro Phe Ile Tyr Glu Glu Asn Gly Glu Leu Thr Gly Tyr Glu Ile 
    50                  55                  60                  


Glu Val Val Arg Ala Ile Phe Lys Asp Ser Asp Lys Tyr Asp Val Lys 
65                  70                  75                  80  


Phe Glu Lys Thr Glu Trp Ser Gly Val Phe Ala Gly Leu Asp Ala Asp 
                85                  90                  95      


Arg Tyr Asn Met Ala Val Asn Asn Leu Ser Tyr Thr Lys Glu Arg Ala 
            100                 105                 110         


Glu Lys Tyr Leu Tyr Ala Ala Pro Ile Ala Gln Asn Pro Asn Val Leu 
        115                 120                 125             


Val Val Lys Lys Asp Asp Ser Ser Ile Lys Ser Leu Asp Asp Ile Gly 
    130                 135                 140                 


Gly Lys Ser Thr Glu Val Val Gln Ala Thr Thr Ser Ala Lys Gln Leu 
145                 150                 155                 160 


Glu Ala Tyr Asn Ala Glu His Thr Asp Asn Pro Thr Ile Leu Asn Tyr 
                165                 170                 175     


Thr Lys Ala Asp Phe Gln Gln Ile Met Val Arg Leu Ser Asp Gly Gln 
            180                 185                 190         


Phe Asp Tyr Lys Ile Phe Asp Lys Ile Gly Val Glu Thr Val Ile Lys 
        195                 200                 205             


Asn Gln Gly Leu Asp Asn Leu Lys Val Ile Glu Leu Pro Ser Asp Gln 
    210                 215                 220                 


Gln Pro Tyr Val Tyr Pro Leu Leu Ala Gln Gly Gln Asp Glu Leu Lys 
225                 230                 235                 240 


Ser Phe Val Asp Lys Arg Ile Lys Glu Leu Tyr Lys Asp Gly Thr Leu 
                245                 250                 255     


Glu Lys Leu Ser Lys Gln Phe Phe Gly Asp Thr Tyr Leu Pro Ala Glu 
            260                 265                 270         


Ala Asp Ile Lys Leu Ala Glu Ala Thr Ala Lys Glu Ala Thr Ala Lys 
        275                 280                 285             


Glu Ala Thr Ala Lys Ala Thr Ala Met Ala Met Ala Asp Leu Lys Lys 
    290                 295                 300                 


Ala Val Asn Glu Pro Glu Lys Pro Ala Glu Glu Glu Pro Glu Asn Pro 
305                 310                 315                 320 


Ala Pro Ala Pro Lys Pro Ala Pro Ala Pro Gln Pro Glu Lys Pro Ala 
                325                 330                 335     


Pro Ala Pro Ala Pro Lys Pro Glu Lys Ser Ala Asp Gln Gln Ala Glu 
            340                 345                 350         


Glu Asp Tyr Ala Arg Arg Ser Glu Glu Glu Tyr Asn Arg Leu Thr Gln 
        355                 360                 365             


Gln Gln Pro Pro Lys Ala Glu Lys Pro Ala Pro Ala Pro Val Pro Lys 
    370                 375                 380                 


Pro Glu Gln Pro Ala Pro Ala Pro Lys Thr Gly Trp Lys Gln Glu Asn 
385                 390                 395                 400 


Gly Met Trp His His His His His His 
                405                 


<210>  64
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP0148/LR/H70

<400>  64

Met Lys Lys Ile Val Lys Tyr Ser Ser Leu Ala Ala Leu Ala Leu Val 
1               5                   10                  15      


Ala Ala Gly Val Leu Ala Ala Cys Ser Gly Gly Ala Lys Lys Glu Gly 
            20                  25                  30          


Glu Ala Ala Ser Lys Lys Glu Ile Ile Val Ala Thr Asn Gly Ser Pro 
        35                  40                  45              


Lys Pro Phe Ile Tyr Glu Glu Asn Gly Glu Leu Thr Gly Tyr Glu Ile 
    50                  55                  60                  


Glu Val Val Arg Ala Ile Phe Lys Asp Ser Asp Lys Tyr Asp Val Lys 
65                  70                  75                  80  


Phe Glu Lys Thr Glu Trp Ser Gly Val Phe Ala Gly Leu Asp Ala Asp 
                85                  90                  95      


Arg Tyr Asn Met Ala Val Asn Asn Leu Ser Tyr Thr Lys Glu Arg Ala 
            100                 105                 110         


Glu Lys Tyr Leu Tyr Ala Ala Pro Ile Ala Gln Asn Pro Asn Val Leu 
        115                 120                 125             


Val Val Lys Lys Asp Asp Ser Ser Ile Lys Ser Leu Asp Asp Ile Gly 
    130                 135                 140                 


Gly Lys Ser Thr Glu Val Val Gln Ala Thr Thr Ser Ala Lys Gln Leu 
145                 150                 155                 160 


Glu Ala Tyr Asn Ala Glu His Thr Asp Asn Pro Thr Ile Leu Asn Tyr 
                165                 170                 175     


Thr Lys Ala Asp Phe Gln Gln Ile Met Val Arg Leu Ser Asp Gly Gln 
            180                 185                 190         


Phe Asp Tyr Lys Ile Phe Asp Lys Ile Gly Val Glu Thr Val Ile Lys 
        195                 200                 205             


Asn Gln Gly Leu Asp Asn Leu Lys Val Ile Glu Leu Pro Ser Asp Gln 
    210                 215                 220                 


Gln Pro Tyr Val Tyr Pro Leu Leu Ala Gln Gly Gln Asp Glu Leu Lys 
225                 230                 235                 240 


Ser Phe Val Asp Lys Arg Ile Lys Glu Leu Tyr Lys Asp Gly Thr Leu 
                245                 250                 255     


Glu Lys Leu Ser Lys Gln Phe Phe Gly Asp Thr Tyr Leu Pro Ala Glu 
            260                 265                 270         


Ala Asp Ile Lys Leu Ala Glu Ala Thr Ala Lys Glu Ala Thr Ala Lys 
        275                 280                 285             


Glu Ala Thr Ala Lys Ala Thr Ala Tyr Phe Lys Glu Gly Leu Glu Lys 
    290                 295                 300                 


Thr Ile Ala Ala Lys Lys Ala Glu Leu Glu Lys Thr Glu Ala Asp Leu 
305                 310                 315                 320 


Lys Lys Ala Val Asn Glu Pro Glu Lys Pro Ala Pro Ala Pro Glu Thr 
                325                 330                 335     


Pro Ala Pro Glu Ala Pro Ala Glu Gln Pro Lys Pro Ala Pro Ala Pro 
            340                 345                 350         


Gln Pro Ala Pro Ala Pro Lys Pro Glu Lys Pro Ala Glu Gln Pro Lys 
        355                 360                 365             


Pro Glu Lys Thr Asp Asp Gln Gln Ala Glu Glu Asp Tyr Ala Arg Arg 
    370                 375                 380                 


Ser Glu Glu Glu Tyr Asn Arg Leu Thr Gln Gln Gln Pro Pro Lys Ala 
385                 390                 395                 400 


Glu Lys Pro Ala Pro Ala Pro Lys Thr Gly Trp Lys Gln Glu Asn Gly 
                405                 410                 415     


Met Trp His His His His His His 
            420                 


<210>  65
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP2108/LR/CD2

<400>  65

Met Ser Ser Lys Phe Met Lys Ser Ala Ala Val Leu Gly Thr Ala Thr 
1               5                   10                  15      


Leu Ala Ser Leu Leu Leu Val Ala Cys Gly Ser Lys Thr Ala Asp Lys 
            20                  25                  30          


Pro Ala Asp Ser Gly Ser Ser Glu Val Lys Glu Leu Thr Val Tyr Val 
        35                  40                  45              


Asp Glu Gly Tyr Lys Ser Tyr Ile Glu Glu Val Ala Lys Ala Tyr Glu 
    50                  55                  60                  


Lys Glu Ala Gly Val Lys Val Thr Leu Lys Thr Gly Asp Ala Leu Gly 
65                  70                  75                  80  


Gly Leu Asp Lys Leu Ser Leu Asp Asn Gln Ser Gly Asn Val Pro Asp 
                85                  90                  95      


Val Met Met Ala Pro Tyr Asp Arg Val Gly Ser Leu Gly Ser Asp Gly 
            100                 105                 110         


Gln Leu Ser Glu Val Lys Leu Ser Asp Gly Ala Lys Thr Asp Asp Thr 
        115                 120                 125             


Thr Lys Ser Leu Val Thr Ala Ala Asn Gly Lys Val Tyr Gly Ala Pro 
    130                 135                 140                 


Ala Val Ile Glu Ser Leu Val Met Tyr Tyr Asn Lys Asp Leu Val Lys 
145                 150                 155                 160 


Asp Ala Pro Lys Thr Phe Ala Asp Leu Glu Asn Leu Ala Lys Asp Ser 
                165                 170                 175     


Lys Tyr Ala Phe Ala Gly Glu Asp Gly Lys Thr Thr Ala Phe Leu Ala 
            180                 185                 190         


Asp Trp Thr Asn Phe Tyr Tyr Thr Tyr Gly Leu Leu Ala Gly Asn Gly 
        195                 200                 205             


Ala Tyr Val Phe Gly Gln Asn Gly Lys Asp Ala Lys Asp Ile Gly Leu 
    210                 215                 220                 


Ala Asn Asp Gly Ser Ile Val Gly Ile Asn Tyr Ala Lys Ser Trp Tyr 
225                 230                 235                 240 


Glu Lys Trp Pro Lys Gly Met Gln Asp Thr Glu Gly Ala Gly Asn Leu 
                245                 250                 255     


Ile Gln Thr Gln Phe Gln Glu Gly Lys Thr Ala Ala Ile Ile Asp Gly 
            260                 265                 270         


Pro Trp Lys Ala Gln Ala Phe Lys Asp Ala Lys Val Asn Tyr Gly Val 
        275                 280                 285             


Ala Thr Ile Pro Thr Leu Pro Asn Gly Lys Glu Tyr Ala Ala Phe Gly 
    290                 295                 300                 


Gly Gly Lys Ala Trp Val Ile Pro Gln Ala Val Lys Asn Leu Glu Ala 
305                 310                 315                 320 


Ser Gln Lys Phe Val Asp Phe Leu Val Ala Thr Glu Gln Gln Lys Val 
                325                 330                 335     


Leu Tyr Asp Lys Thr Asn Glu Ile Pro Ala Asn Thr Glu Ala Arg Ser 
            340                 345                 350         


Tyr Ala Glu Gly Lys Asn Asp Glu Leu Thr Thr Ala Val Ile Lys Gln 
        355                 360                 365             


Phe Lys Asn Thr Gln Pro Leu Pro Asn Ile Ser Gln Met Ser Ala Val 
    370                 375                 380                 


Trp Asp Pro Ala Lys Asn Met Leu Phe Asp Ala Val Ser Gly Gln Lys 
385                 390                 395                 400 


Asp Ala Lys Thr Ala Ala Asn Asp Ala Val Thr Leu Ile Lys Glu Thr 
                405                 410                 415     


Ile Lys Gln Lys Phe Gly Glu Leu Ala Glu Ala Thr Ala Lys Glu Ala 
            420                 425                 430         


Thr Ala Lys Glu Ala Thr Ala Lys Ala Thr Ala Met Ala Met Ala Asp 
        435                 440                 445             


Leu Lys Lys Ala Val Asn Glu Pro Glu Lys Pro Ala Glu Glu Glu Pro 
    450                 455                 460                 


Glu Asn Pro Ala Pro Ala Pro Lys Pro Ala Pro Ala Pro Gln Pro Glu 
465                 470                 475                 480 


Lys Pro Ala Pro Ala Pro Ala Pro Lys Pro Glu Lys Ser Ala Asp Gln 
                485                 490                 495     


Gln Ala Glu Glu Asp Tyr Ala Arg Arg Ser Glu Glu Glu Tyr Asn Arg 
            500                 505                 510         


Leu Thr Gln Gln Gln Pro Pro Lys Ala Glu Lys Pro Ala Pro Ala Pro 
        515                 520                 525             


Val Pro Lys Pro Glu Gln Pro Ala Pro Ala Pro Lys Thr Gly Trp Lys 
    530                 535                 540                 


Gln Glu Asn Gly Met Trp His His His His His His 
545                 550                 555     


<210>  66
<211>  571
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP2108/LR/H70

<400>  66

Met Ser Ser Lys Phe Met Lys Ser Ala Ala Val Leu Gly Thr Ala Thr 
1               5                   10                  15      


Leu Ala Ser Leu Leu Leu Val Ala Cys Gly Ser Lys Thr Ala Asp Lys 
            20                  25                  30          


Pro Ala Asp Ser Gly Ser Ser Glu Val Lys Glu Leu Thr Val Tyr Val 
        35                  40                  45              


Asp Glu Gly Tyr Lys Ser Tyr Ile Glu Glu Val Ala Lys Ala Tyr Glu 
    50                  55                  60                  


Lys Glu Ala Gly Val Lys Val Thr Leu Lys Thr Gly Asp Ala Leu Gly 
65                  70                  75                  80  


Gly Leu Asp Lys Leu Ser Leu Asp Asn Gln Ser Gly Asn Val Pro Asp 
                85                  90                  95      


Val Met Met Ala Pro Tyr Asp Arg Val Gly Ser Leu Gly Ser Asp Gly 
            100                 105                 110         


Gln Leu Ser Glu Val Lys Leu Ser Asp Gly Ala Lys Thr Asp Asp Thr 
        115                 120                 125             


Thr Lys Ser Leu Val Thr Ala Ala Asn Gly Lys Val Tyr Gly Ala Pro 
    130                 135                 140                 


Ala Val Ile Glu Ser Leu Val Met Tyr Tyr Asn Lys Asp Leu Val Lys 
145                 150                 155                 160 


Asp Ala Pro Lys Thr Phe Ala Asp Leu Glu Asn Leu Ala Lys Asp Ser 
                165                 170                 175     


Lys Tyr Ala Phe Ala Gly Glu Asp Gly Lys Thr Thr Ala Phe Leu Ala 
            180                 185                 190         


Asp Trp Thr Asn Phe Tyr Tyr Thr Tyr Gly Leu Leu Ala Gly Asn Gly 
        195                 200                 205             


Ala Tyr Val Phe Gly Gln Asn Gly Lys Asp Ala Lys Asp Ile Gly Leu 
    210                 215                 220                 


Ala Asn Asp Gly Ser Ile Val Gly Ile Asn Tyr Ala Lys Ser Trp Tyr 
225                 230                 235                 240 


Glu Lys Trp Pro Lys Gly Met Gln Asp Thr Glu Gly Ala Gly Asn Leu 
                245                 250                 255     


Ile Gln Thr Gln Phe Gln Glu Gly Lys Thr Ala Ala Ile Ile Asp Gly 
            260                 265                 270         


Pro Trp Lys Ala Gln Ala Phe Lys Asp Ala Lys Val Asn Tyr Gly Val 
        275                 280                 285             


Ala Thr Ile Pro Thr Leu Pro Asn Gly Lys Glu Tyr Ala Ala Phe Gly 
    290                 295                 300                 


Gly Gly Lys Ala Trp Val Ile Pro Gln Ala Val Lys Asn Leu Glu Ala 
305                 310                 315                 320 


Ser Gln Lys Phe Val Asp Phe Leu Val Ala Thr Glu Gln Gln Lys Val 
                325                 330                 335     


Leu Tyr Asp Lys Thr Asn Glu Ile Pro Ala Asn Thr Glu Ala Arg Ser 
            340                 345                 350         


Tyr Ala Glu Gly Lys Asn Asp Glu Leu Thr Thr Ala Val Ile Lys Gln 
        355                 360                 365             


Phe Lys Asn Thr Gln Pro Leu Pro Asn Ile Ser Gln Met Ser Ala Val 
    370                 375                 380                 


Trp Asp Pro Ala Lys Asn Met Leu Phe Asp Ala Val Ser Gly Gln Lys 
385                 390                 395                 400 


Asp Ala Lys Thr Ala Ala Asn Asp Ala Val Thr Leu Ile Lys Glu Thr 
                405                 410                 415     


Ile Lys Gln Lys Phe Gly Glu Leu Ala Glu Ala Thr Ala Lys Glu Ala 
            420                 425                 430         


Thr Ala Lys Glu Ala Thr Ala Lys Ala Thr Ala Tyr Phe Lys Glu Gly 
        435                 440                 445             


Leu Glu Lys Thr Ile Ala Ala Lys Lys Ala Glu Leu Glu Lys Thr Glu 
    450                 455                 460                 


Ala Asp Leu Lys Lys Ala Val Asn Glu Pro Glu Lys Pro Ala Pro Ala 
465                 470                 475                 480 


Pro Glu Thr Pro Ala Pro Glu Ala Pro Ala Glu Gln Pro Lys Pro Ala 
                485                 490                 495     


Pro Ala Pro Gln Pro Ala Pro Ala Pro Lys Pro Glu Lys Pro Ala Glu 
            500                 505                 510         


Gln Pro Lys Pro Glu Lys Thr Asp Asp Gln Gln Ala Glu Glu Asp Tyr 
        515                 520                 525             


Ala Arg Arg Ser Glu Glu Glu Tyr Asn Arg Leu Thr Gln Gln Gln Pro 
    530                 535                 540                 


Pro Lys Ala Glu Lys Pro Ala Pro Ala Pro Lys Thr Gly Trp Lys Gln 
545                 550                 555                 560 


Glu Asn Gly Met Trp His His His His His His 
                565                 570     


<210>  67
<211>  2025
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP2108/SP0148 fusion

<400>  67
atgtcatcta aatttatgaa gagcgctgcg gtgcttggaa ctgctacact tgctagcttg       60

cttttggtag cttgcggaag caaaactgct gataagcctg ctgattctgg ttcatctgaa      120

gtcaaagaac tcactgtata tgtagacgag ggatataaga gctatattga agaggttgct      180

aaagcttatg aaaaagaagc tggagtaaaa gtcactctta aaactggtga tgctctagga      240

ggtcttgata aactttctct tgacaaccaa tctggtaatg tccctgatgt tatgatggct      300

ccatacgacc gtgtaggtag ccttggttct gacggacaac tttcagaagt gaaattgagc      360

gatggtgcta aaacagacga cacaactaaa tctcttgtaa cagctgctaa tggtaaagtt      420

tacggtgctc ctgccgttat cgagtcactt gttatgtact acaacaaaga cttggtgaaa      480

gatgctccaa aaacatttgc tgacttggaa aaccttgcta aagatagcaa atacgcattc      540

gctggtgaag atggtaaaac tactgccttc ctagctgact ggacaaactt ctactataca      600

tatggacttc ttgccggtaa cggtgcttac gtctttggcc aaaacggtaa agacgctaaa      660

gacatcggtc ttgcaaacga cggttctatc gtaggtatca actacgctaa atcttggtac      720

gaaaaatggc ctaaaggtat gcaagataca gaaggtgctg gaaacttaat ccaaactcaa      780

ttccaagaag gtaaaacagc tgctatcatc gacggacctt ggaaagctca agcctttaaa      840

gatgctaaag taaactacgg agttgcaact atcccaactc ttccaaatgg aaaagaatat      900

gctgcattcg gtggtggtaa agcttgggtc attcctcaag ccgttaagaa ccttgaagct      960

tctcaaaaat ttgtagactt ccttgttgca actgaacaac aaaaagtatt atatgataag     1020

actaacgaaa tcccagctaa tactgaggct cgttcatacg ctgaaggtaa aaacgatgag     1080

ttgacaacag ctgttatcaa acagttcaag aacactcaac cactgccaaa catctctcaa     1140

atgtctgcag tttgggatcc agcgaaaaat atgctctttg atgctgtaag tggtcaaaaa     1200

gatgctaaaa cagctgctaa cgatgctgta acattgatca aagaaacaat caaacaaaaa     1260

tttggtgaat cagggggtgc taagaaagaa ggagaagcag ctagcaagaa agaaatcatc     1320

gttgcaacca atggatcacc aaagccattt atctatgaag aaaatggcga attgactggt     1380

tacgagattg aagtcgttcg cgctatcttt aaagattctg acaaatatga tgtcaagttt     1440

gaaaagacag aatggtcagg tgtctttgct ggtcttgacg ctgatcgtta caatatggct     1500

gtcaacaatc ttagctacac taaagaacgt gcggagaaat acctctatgc cgcaccaatt     1560

gcccaaaatc ctaatgtcct tgtcgtgaag aaagatgact ctagtatcaa gtctctcgat     1620

gatatcggtg gaaaatcgac ggaagtcgtt caagccacta catcagctaa gcagttagaa     1680

gcatacaatg ctgaacacac ggacaaccca actatcctta actatactaa ggcagacttc     1740

caacaaatca tggtacgttt gagcgatgga caatttgact ataagatttt tgataaaatc     1800

ggtgttgaaa cagtgatcaa gaaccaaggt ttggacaact tgaaagttat cgaacttcca     1860

agcgaccaac aaccgtacgt ttacccactt cttgctcagg gtcaagatga gttgaaatcg     1920

tttgtagaca aacgcatcaa agaactttat aaagatggaa ctcttgaaaa attgtctaaa     1980

caattcttcg gagacactta tctaccggca gaagctgata ttaaa                     2025


<210>  68
<211>  2022
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP0148/SP2108 fusion

<400>  68
atgaaaaaaa tcgttaaata ctcatctctt gcagcccttg ctcttgttgc tgcaggtgtg       60

cttgcggctt gctcaggggg tgctaagaaa gaaggagaag cagctagcaa gaaagaaatc      120

atcgttgcaa ccaatggatc accaaagcca tttatctatg aagaaaatgg cgaattgact      180

ggttacgaga ttgaagtcgt tcgcgctatc tttaaagatt ctgacaaata tgatgtcaag      240

tttgaaaaga cagaatggtc aggtgtcttt gctggtcttg acgctgatcg ttacaatatg      300

gctgtcaaca atcttagcta cactaaagaa cgtgcggaga aatacctcta tgccgcacca      360

attgcccaaa atcctaatgt ccttgtcgtg aagaaagatg actctagtat caagtctctc      420

gatgatatcg gtggaaaatc gacggaagtc gttcaagcca ctacatcagc taagcagtta      480

gaagcataca atgctgaaca cacggacaac ccaactatcc ttaactatac taaggcagac      540

ttscaacaaa tcatggtacg tttgagcgat ggacaatttg actataagat ttttgataaa      600

atcggtgttg aaacagtgat caagaaccaa ggtttggaca acttgaaagt tatcgaactt      660

ccaagcgacc aacaaccgta cgtttaccca cttcttgctc agggtcaaga tgagttgaaa      720

tcgtttgtag acaaacgcat caaagaactt tataaagatg gaactcttga aaaattgtct      780

aaacaattct tcggagacac ttatctaccg gcagaagctg atattaaagg aagcaaaact      840

gctgataagc ctgctgattc tggttcatct gaagtcaaag aactcactgt atatgtagac      900

gagggatata agagctatat tgaagaggtt gctaaagctt atgaaaaaga agctggagta      960

aaagtcactc ttaaaactgg tgatgctcta ggaggtcttg ataaactttc tcttgacaac     1020

caatctggta atgtccctga tgttatgatg gctccatacg accgtgtagg tagccttggt     1080

tctgacggac aactttcaga agtgaaattg agcgatggtg ctaaaacaga cgacacaact     1140

aaatctcttg taacagctgc taatggtaaa gtttacggtg ctcctgccgt tatcgagtca     1200

cttgttatgt actacaacaa agacttggtg aaagatgctc caaaaacatt tgctgacttg     1260

gaaaaccttg ctaaagatag caaatacgca ttcgctggtg aagatggtaa aactactgcc     1320

ttcctagctg actggacaaa cttctactat acatatggac ttcttgccgg taacggtgct     1380

tacgtctttg gccaaaacgg taaagacgct aaagacatcg gtcttgcaaa cgacggttct     1440

atcgtaggta tcaactacgc taaatcttgg tacgaaaaat ggcctaaagg tatgcaagat     1500

acagaaggtg ctggaaactt aatccaaact caattccaag aaggtaaaac agctgctatc     1560

atcgacggac cttggaaagc tcaagccttt aaagatgcta aagtaaacta cggagttgca     1620

actatcccaa ctcttccaaa tggaaaagaa tatgctgcat tcggtggtgg taaagcttgg     1680

gtcattcctc aagccgttaa gaaccttgaa gcttctcaaa aatttgtaga cttccttgtt     1740

gcaactgaac aacaaaaagt attatatgat aagactaacg aaatcccagc taatactgag     1800

gctcgttcat acgctgaagg taaaaacgat gagttgacaa cagctgttat caaacagttc     1860

aagaacactc aaccactgcc aaacatctct caaatgtctg cagtttggga tccagcgaaa     1920

aatatgctct ttgatgctgt aagtggtcaa aaagatgcta aaacagctgc taacgatgct     1980

gtaacattga tcaaagaaac aatcaaacaa aaatttggtg aa                        2022


<210>  69
<211>  1563
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP2108/SP1912 fusion

<400>  69
atgtcatcta aatttatgaa gagcgctgcg gtgcttggaa ctgctacact tgctagcttg       60

cttttggtag cttgcggaag caaaactgct gataagcctg ctgattctgg ttcatctgaa      120

gtcaaagaac tcactgtata tgtagacgag ggatataaga gctatattga agaggttgct      180

aaagcttatg aaaaagaagc tggagtaaaa gtcactctta aaactggtga tgctctagga      240

ggtcttgata aactttctct tgacaaccaa tctggtaatg tccctgatgt tatgatggct      300

ccatacgacc gtgtaggtag ccttggttct gacggacaac tttcagaagt gaaattgagc      360

gatggtgcta aaacagacga cacaactaaa tctcttgtaa cagctgctaa tggtaaagtt      420

tacggtgctc ctgccgttat cgagtcactt gttatgtact acaacaaaga cttggtgaaa      480

gatgctccaa aaacatttgc tgacttggaa aaccttgcta aagatagcaa atacgcattc      540

gctggtgaag atggtaaaac tactgccttc ctagctgact ggacaaactt ctactataca      600

tatggacttc ttgccggtaa cggtgcttac gtctttggcc aaaacggtaa agacgctaaa      660

gacatcggtc ttgcaaacga cggttctatc gtaggtatca actacgctaa atcttggtac      720

gaaaaatggc ctaaaggtat gcaagataca gaaggtgctg gaaacttaat ccaaactcaa      780

ttccaagaag gtaaaacagc tgctatcatc gacggacctt ggaaagctca agcctttaaa      840

gatgctaaag taaactacgg agttgcaact atcccaactc ttccaaatgg aaaagaatat      900

gctgcattcg gtggtggtaa agcttgggtc attcctcaag ccgttaagaa ccttgaagct      960

tctcaaaaat ttgtagactt ccttgttgca actgaacaac aaaaagtatt atatgataag     1020

actaacgaaa tcccagctaa tactgaggct cgttcatacg ctgaaggtaa aaacgatgag     1080

ttgacaacag ctgttatcaa acagttcaag aacactcaac cactgccaaa catctctcaa     1140

atgtctgcag tttgggatcc agcgaaaaat atgctctttg atgctgtaag tggtcaaaaa     1200

gatgctaaaa cagctgctaa cgatgctgta acattgatca aagaaacaat caaacaaaaa     1260

tttggtgaaa atggtatgaa agctaaaaaa atgtggatgg caggcttggc tctgctaggt     1320

atcggaagcc ttgctcttgc tacgaaaaaa gttgcagatg accgtaagct catgaagact     1380

caggaagagt tgacagagat tgtgcgagac catttttccg acatggggga aattgcgacc     1440

ctttatgttc aagtttacga aagcagtctg gagagcttgg ttggtggcgt catttttgag     1500

gatggccgtc attatacctt tgtctatgaa aatgaagacc tagtctatga ggaggaagtc     1560

tta                                                                   1563


<210>  70
<211>  1122
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP0148/SP1912 fusion

<400>  70
atgaaaaaaa tcgttaaata ctcatctctt gcagcccttg ctcttgttgc tgcaggtgtg       60

cttgcggctt gctcaggggg tgctaagaaa gaaggagaag cagctagcaa gaaagaaatc      120

atcgttgcaa ccaatggatc accaaagcca tttatctatg aagaaaatgg cgaattgact      180

ggttacgaga ttgaagtcgt tcgcgctatc tttaaagatt ctgacaaata tgatgtcaag      240

tttgaaaaga cagaatggtc aggtgtcttt gctggtcttg acgctgatcg ttacaatatg      300

gctgtcaaca atcttagcta cactaaagaa cgtgcggaga aatacctcta tgccgcacca      360

attgcccaaa atcctaatgt ccttgtcgtg aagaaagatg actctagtat caagtctctc      420

gatgatatcg gtggaaaatc gacggaagtc gttcaagcca ctacatcagc taagcagtta      480

gaagcataca atgctgaaca cacggacaac ccaactatcc ttaactatac taaggcagac      540

ttccaacaaa tcatggtacg tttgagcgat ggacaatttg actataagat ttttgataaa      600

atcggtgttg aaacagtgat caagaaccaa ggtttggaca acttgaaagt tatcgaactt      660

ccaagcgacc aacaaccgta cgtttaccca cttcttgctc agggtcaaga tgagttgaaa      720

tcgtttgtag acaaacgcat caaagaactt tataaagatg gaactcttga aaaattgtct      780

aaacaattct tcggagacac ttatctaccg gcagaagctg atattaaaaa tggtatgaaa      840

gctaaaaaaa tgtggatggc aggcttggct ctgctaggta tcggaagcct tgctcttgct      900

acgaaaaaag ttgcagatga ccgtaagctc atgaagactc aggaagagtt gacagagatt      960

gtgcgagacc atttttccga catgggggaa attgcgaccc tttatgttca agtttacgaa     1020

agcagtctgg agagcttggt tggtggcgtc atttttgagg atggccgtca ttataccttt     1080

gtctatgaaa atgaagacct agtctatgag gaggaagtct ta                        1122


<210>  71
<211>  2322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP2108/SP1912/SP0148 fusion

<400>  71
atgtcatcta aatttatgaa gagcgctgcg gtgcttggaa ctgctacact tgctagcttg       60

cttttggtag cttgcggaag caaaactgct gataagcctg ctgattctgg ttcatctgaa      120

gtcaaagaac tcactgtata tgtagacgag ggatataaga gctatattga agaggttgct      180

aaagcttatg aaaaagaagc tggagtaaaa gtcactctta aaactggtga tgctctagga      240

ggtcttgata aactttctct tgacaaccaa tctggtaatg tccctgatgt tatgatggct      300

ccatacgacc gtgtaggtag ccttggttct gacggacaac tttcagaagt gaaattgagc      360

gatggtgcta aaacagacga cacaactaaa tctcttgtaa cagctgctaa tggtaaagtt      420

tacggtgctc ctgccgttat cgagtcactt gttatgtact acaacaaaga cttggtgaaa      480

gatgctccaa aaacatttgc tgacttggaa aaccttgcta aagatagcaa atacgcattc      540

gctggtgaag atggtaaaac tactgccttc ctagctgact ggacaaactt ctactataca      600

tatggacttc ttgccggtaa cggtgcttac gtctttggcc aaaacggtaa agacgctaaa      660

gacatcggtc ttgcaaacga cggttctatc gtaggtatca actacgctaa atcttggtac      720

gaaaaatggc ctaaaggtat gcaagataca gaaggtgctg gaaacttaat ccaaactcaa      780

ttccaagaag gtaaaacagc tgctatcatc gacggacctt ggaaagctca agcctttaaa      840

gatgctaaag taaactacgg agttgcaact atcccaactc ttccaaatgg aaaagaatat      900

gctgcattcg gtggtggtaa agcttgggtc attcctcaag ccgttaagaa ccttgaagct      960

tctcaaaaat ttgtagactt ccttgttgca actgaacaac aaaaagtatt atatgataag     1020

actaacgaaa tcccagctaa tactgaggct cgttcatacg ctgaaggtaa aaacgatgag     1080

ttgacaacag ctgttatcaa acagttcaag aacactcaac cactgccaaa catctctcaa     1140

atgtctgcag tttgggatcc agcgaaaaat atgctctttg atgctgtaag tggtcaaaaa     1200

gatgctaaaa cagctgctaa cgatgctgta acattgatca aagaaacaat caaacaaaaa     1260

tttggtgaaa atggtatgaa agctaaaaaa atgtggatgg caggcttggc tctgctaggt     1320

atcggaagcc ttgctcttgc tacgaaaaaa gttgcagatg accgtaagct catgaagact     1380

caggaagagt tgacagagat tgtgcgagac catttttccg acatggggga aattgcgacc     1440

ctttatgttc aagtttacga aagcagtctg gagagcttgg ttggtggcgt catttttgag     1500

gatggccgtc attatacctt tgtctatgaa aatgaagacc tagtctatga ggaggaagtc     1560

ttatgctcag ggggtgctaa gaaagaagga gaagcagcta gcaagaaaga aatcatcgtt     1620

gcaaccaatg gatcaccaaa gccatttatc tatgaagaaa atggcgaatt gactggttac     1680

gagattgaag tcgttcgcgc tatctttaaa gattctgaca aatatgatgt caagtttgaa     1740

aagacagaat ggtcaggtgt ctttgctggt cttgacgctg atcgttacaa tatggctgtc     1800

aacaatctta gctacactaa agaacgtgcg gagaaatacc tctatgccgc accaattgcc     1860

caaaatccta atgtccttgt cgtgaagaaa gatgactcta gtatcaagtc tctcgatgat     1920

atcggtggaa aatcgacgga agtcgttcaa gccactacat cagctaagca gttagaagca     1980

tacaatgctg aacacacgga caacccaact atccttaact atactaaggc agacttccaa     2040

caaatcatgg tacgtttgag cgatggacaa tttgactata agatttttga taaaatcggt     2100

gttgaaacag tgatcaagaa ccaaggtttg gacaacttga aagttatcga acttccaagc     2160

gaccaacaac cgtacgttta cccacttctt gctcagggtc aagatgagtt gaaatcgttt     2220

gtagacaaac gcatcaaaga actttataaa gatggaactc ttgaaaaatt gtctaaacaa     2280

ttcttcggag acacttatct accggcagaa gctgatatta aa                        2322


<210>  72
<211>  2337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP0148/SP1912/SP2108 fusion

<400>  72
atgaaaaaaa tcgttaaata ctcatctctt gcagcccttg ctcttgttgc tgcaggtgtg       60

cttgcggctt gctcaggggg tgctaagaaa gaaggagaag cagctagcaa gaaagaaatc      120

atcgttgcaa ccaatggatc accaaagcca tttatctatg aagaaaatgg cgaattgact      180

ggttacgaga ttgaagtcgt tcgcgctatc tttaaagatt ctgacaaata tgatgtcaag      240

tttgaaaaga cagaatggtc aggtgtcttt gctggtcttg acgctgatcg ttacaatatg      300

gctgtcaaca atcttagcta cactaaagaa cgtgcggaga aatacctcta tgccgcacca      360

attgcccaaa atcctaatgt ccttgtcgtg aagaaagatg actctagtat caagtctctc      420

gatgatatcg gtggaaaatc gacggaagtc gttcaagcca ctacatcagc taagcagtta      480

gaagcataca atgctgaaca cacggacaac ccaactatcc ttaactatac taaggcagac      540

ttccaacaaa tcatggtacg tttgagcgat ggacaatttg actataagat ttttgataaa      600

atcggtgttg aaacagtgat caagaaccaa ggtttggaca acttgaaagt tatcgaactt      660

ccaagcgacc aacaaccgta cgtttaccca cttcttgctc agggtcaaga tgagttgaaa      720

tcgtttgtag acaaacgcat caaagaactt tataaagatg gaactcttga aaaattgtct      780

aaacaattct tcggagacac ttatctaccg gcagaagctg atattaaaaa tggtatgaaa      840

gctaaaaaaa tgtggatggc aggcttggct ctgctaggta tcggaagcct tgctcttgct      900

acgaaaaaag ttgcagatga ccgtaagctc atgaagactc aggaagagtt gacagagatt      960

gtgcgagacc atttttccga catgggggaa attgcgaccc tttatgttca agtttacgaa     1020

agcagtctgg agagcttggt tggtggcgtc atttttgagg atggccgtca ttataccttt     1080

gtctatgaaa atgaagacct agtctatgag gaggaagtct taggaagcaa aactgctgat     1140

aagcctgctg attctggttc atctgaagtc aaagaactca ctgtatatgt agacgaggga     1200

tataagagct atattgaaga ggttgctaaa gcttatgaaa aagaagctgg agtaaaagtc     1260

actcttaaaa ctggtgatgc tctaggaggt cttgataaac tttctcttga caaccaatct     1320

ggtaatgtcc ctgatgttat gatggctcca tacgaccgtg taggtagcct tggttctgac     1380

ggacaacttt cagaagtgaa attgagcgat ggtgctaaaa cagacgacac aactaaatct     1440

cttgtaacag ctgctaatgg taaagtttac ggtgctcctg ccgttatcga gtcacttgtt     1500

atgtactaca acaaagactt ggtgaaagat gctccaaaaa catttgctga cttggaaaac     1560

cttgctaaag atagcaaata cgcattcgct ggtgaagatg gtaaaactac tgccttccta     1620

gctgactgga caaacttcta ctatacatat ggacttcttg ccggtaacgg tgcttacgtc     1680

tttggccaaa acggtaaaga cgctaaagac atcggtcttg caaacgacgg ttctatcgta     1740

ggtatcaact acgctaaatc ttggtacgaa aaatggccta aaggtatgca agatacagaa     1800

ggtgctggaa acttaatcca aactcaattc caagaaggta aaacagctgc tatcatcgac     1860

ggaccttgga aagctcaagc ctttaaagat gctaaagtaa actacggagt tgcaactatc     1920

ccaactcttc caaatggaaa agaatatgct gcattcggtg gtggtaaagc ttgggtcatt     1980

cctcaagccg ttaagaacct tgaagcttct caaaaatttg tagacttcct tgttgcaact     2040

gaacaacaaa aagtattata tgataagact aacgaaatcc cagctaatac tgaggctcgt     2100

tcatacgctg aaggtaaaaa cgatgagttg acaacagctg ttatcaaaca gttcaagaac     2160

actcaaccac tgccaaacat ctctcaaatg tctgcagttt gggatccagc gaaaaatatg     2220

ctctttgatg ctgtaagtgg tcaaaaagat gctaaaacag ctgctaacga tgctgtaaca     2280

ttgatcaaag aaacaatcaa acaaaaattt ggtgaacacc accaccacca ccactga        2337


<210>  73
<211>  2319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP2108/SP0148/SP1912 fusion

<400>  73
atgtcatcta aatttatgaa gagcgctgcg gtgcttggaa ctgctacact tgctagcttg       60

cttttggtag cttgcggaag caaaactgct gataagcctg ctgattctgg ttcatctgaa      120

gtcaaagaac tcactgtata tgtagacgag ggatataaga gctatattga agaggttgct      180

aaagcttatg aaaaagaagc tggagtaaaa gtcactctta aaactggtga tgctctagga      240

ggtcttgata aactttctct tgacaaccaa tctggtaatg tccctgatgt tatgatggct      300

ccatacgacc gtgtaggtag ccttggttct gacggacaac tttcagaagt gaaattgagc      360

gatggtgcta aaacagacga cacaactaaa tctcttgtaa cagctgctaa tggtaaagtt      420

tacggtgctc ctgccgttat cgagtcactt gttatgtact acaacaaaga cttggtgaaa      480

gatgctccaa aaacatttgc tgacttggaa aaccttgcta aagatagcaa atacgcattc      540

gctggtgaag atggtaaaac tactgccttc ctagctgact ggacaaactt ctactataca      600

tatggacttc ttgccggtaa cggtgcttac gtctttggcc aaaacggtaa agacgctaaa      660

gacatcggtc ttgcaaacga cggttctatc gtaggtatca actacgctaa atcttggtac      720

gaaaaatggc ctaaaggtat gcaagataca gaaggtgctg gaaacttaat ccaaactcaa      780

ttccaagaag gtaaaacagc tgctatcatc gacggacctt ggaaagctca agcctttaaa      840

gatgctaaag taaactacgg agttgcaact atcccaactc ttccaaatgg aaaagaatat      900

gctgcattcg gtggtggtaa agcttgggtc attcctcaag ccgttaagaa ccttgaagct      960

tctcaaaaat ttgtagactt ccttgttgca actgaacaac aaaaagtatt atatgataag     1020

actaacgaaa tcccagctaa tactgaggct cgttcatacg ctgaaggtaa aaacgatgag     1080

ttgacaacag ctgttatcaa acagttcaag aacactcaac cactgccaaa catctctcaa     1140

atgtctgcag tttgggatcc agcgaaaaat atgctctttg atgctgtaag tggtcaaaaa     1200

gatgctaaaa cagctgctaa cgatgctgta acattgatca aagaaacaat caaacaaaaa     1260

tttggtgaat cagggggtgc taagaaagaa ggagaagcag ctagcaagaa agaaatcatc     1320

gttgcaacca atggatcacc aaagccattt atctatgaag aaaatggcga attgactggt     1380

tacgagattg aagtcgttcg cgctatcttt aaagattctg acaaatatga tgtcaagttt     1440

gaaaagacag aatggtcagg tgtctttgct ggtcttgacg ctgatcgtta caatatggct     1500

gtcaacaatc ttagctacac taaagaacgt gcggagaaat acctctatgc cgcaccaatt     1560

gcccaaaatc ctaatgtcct tgtcgtgaag aaagatgact ctagtatcaa gtctctcgat     1620

gatatcggtg gaaaatcgac ggaagtcgtt caagccacta catcagctaa gcagttagaa     1680

gcatacaatg ctgaacacac ggacaaccca actatcctta actatactaa ggcagacttc     1740

caacaaatca tggtacgttt gagcgatgga caatttgact ataagatttt tgataaaatc     1800

ggtgttgaaa cagtgatcaa gaaccaaggt ttggacaact tgaaagttat cgaacttcca     1860

agcgaccaac aaccgtacgt ttacccactt cttgctcagg gtcaagatga gttgaaatcg     1920

tttgtagaca aacgcatcaa agaactttat aaagatggaa ctcttgaaaa attgtctaaa     1980

caattcttcg gagacactta tctaccggca gaagctgata ttaaaaatgg tatgaaagct     2040

aaaaaaatgt ggatggcagg cttggctctg ctaggtatcg gaagccttgc tcttgctacg     2100

aaaaaagttg cagatgaccg taagctcatg aagactcagg aagagttgac agagattgtg     2160

cgagaccatt tttccgacat gggggaaatt gcgacccttt atgttcaagt ttacgaaagc     2220

agtctggaga gcttggttgg tggcgtcatt tttgaggatg gccgtcatta tacctttgtc     2280

tatgaaaatg aagacctagt ctatgaggag gaagtctta                            2319


<210>  74
<211>  2316
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP0148/SP2108/SP1912 fusion

<400>  74
atgaaaaaaa tcgttaaata ctcatctctt gcagcccttg ctcttgttgc tgcaggtgtg       60

cttgcggctt gctcaggggg tgctaagaaa gaaggagaag cagctagcaa gaaagaaatc      120

atcgttgcaa ccaatggatc accaaagcca tttatctatg aagaaaatgg cgaattgact      180

ggttacgaga ttgaagtcgt tcgcgctatc tttaaagatt ctgacaaata tgatgtcaag      240

tttgaaaaga cagaatggtc aggtgtcttt gctggtcttg acgctgatcg ttacaatatg      300

gctgtcaaca atcttagcta cactaaagaa cgtgcggaga aatacctcta tgccgcacca      360

attgcccaaa atcctaatgt ccttgtcgtg aagaaagatg actctagtat caagtctctc      420

gatgatatcg gtggaaaatc gacggaagtc gttcaagcca ctacatcagc taagcagtta      480

gaagcataca atgctgaaca cacggacaac ccaactatcc ttaactatac taaggcagac      540

ttccaacaaa tcatggtacg tttgagcgat ggacaatttg actataagat ttttgataaa      600

atcggtgttg aaacagtgat caagaaccaa ggtttggaca acttgaaagt tatcgaactt      660

ccaagcgacc aacaaccgta cgtttaccca cttcttgctc agggtcaaga tgagttgaaa      720

tcgtttgtag acaaacgcat caaagaactt tataaagatg gaactcttga aaaattgtct      780

aaacaattct tcggagacac ttatctaccg gcagaagctg atattaaagg aagcaaaact      840

gctgataagc ctgctgattc tggttcatct gaagtcaaag aactcactgt atatgtagac      900

gagggatata agagctatat tgaagaggtt gctaaagctt atgaaaaaga agctggagta      960

aaagtcactc ttaaaactgg tgatgctcta ggaggtcttg ataaactttc tcttgacaac     1020

caatctggta atgtccctga tgttatgatg gctccatacg accgtgtagg tagccttggt     1080

tctgacggac aactttcaga agtgaaattg agcgatggtg ctaaaacaga cgacacaact     1140

aaatctcttg taacagctgc taatggtaaa gtttacggtg ctcctgccgt tatcgagtca     1200

cttgttatgt actacaacaa agacttggtg aaagatgctc caaaaacatt tgctgacttg     1260

gaaaaccttg ctaaagatag caaatacgca ttcgctggtg aagatggtaa aactactgcc     1320

ttcctagctg actggacaaa cttctactat acatatggac ttcttgccgg taacggtgct     1380

tacgtctttg gccaaaacgg taaagacgct aaagacatcg gtcttgcaaa cgacggttct     1440

atcgtaggta tcaactacgc taaatcttgg tacgaaaaat ggcctaaagg tatgcaagat     1500

acagaaggtg ctggaaactt aatccaaact caattccaag aaggtaaaac agctgctatc     1560

atcgacggac cttggaaagc tcaagccttt aaagatgcta aagtaaacta cggagttgca     1620

actatcccaa ctcttccaaa tggaaaagaa tatgctgcat tcggtggtgg taaagcttgg     1680

gtcattcctc aagccgttaa gaaccttgaa gcttctcaaa aatttgtaga cttccttgtt     1740

gcaactgaac aacaaaaagt attatatgat aagactaacg aaatcccagc taatactgag     1800

gctcgttcat acgctgaagg taaaaacgat gagttgacaa cagctgttat caaacagttc     1860

aagaacactc aaccactgcc aaacatctct caaatgtctg cagtttggga tccagcgaaa     1920

aatatgctct ttgatgctgt aagtggtcaa aaagatgcta aaacagctgc taacgatgct     1980

gtaacattga tcaaagaaac aatcaaacaa aaatttggtg aaaatggtat gaaagctaaa     2040

aaaatgtgga tggcaggctt ggctctgcta ggtatcggaa gccttgctct tgctacgaaa     2100

aaagttgcag atgaccgtaa gctcatgaag actcaggaag agttgacaga gattgtgcga     2160

gaccattttt ccgacatggg ggaaattgcg accctttatg ttcaagttta cgaaagcagt     2220

ctggagagct tggttggtgg cgtcattttt gaggatggcc gtcattatac ctttgtctat     2280

gaaaatgaag acctagtcta tgaggaggaa gtctta                               2316


<210>  75
<211>  1170
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP0148/CD2

<400>  75
atgaaaaaaa tcgttaaata ctcatctctt gcagcccttg ctcttgttgc tgcaggtgtg       60

cttgcggctt gctcaggggg tgctaagaaa gaaggagaag cagctagcaa gaaagaaatc      120

atcgttgcaa ccaatggatc accaaagcca tttatctatg aagaaaatgg cgaattgact      180

ggttacgaga ttgaagtcgt tcgcgctatc tttaaagatt ctgacaaata tgatgtcaag      240

tttgaaaaga cagaatggtc aggtgtcttt gctggtcttg acgctgatcg ttacaatatg      300

gctgtcaaca atcttagcta cactaaagaa cgtgcggaga aatacctcta tgccgcacca      360

attgcccaaa atcctaatgt ccttgtcgtg aagaaagatg actctagtat caagtctctc      420

gatgatatcg gtggaaaatc gacggaagtc gttcaagcca ctacatcagc taagcagtta      480

gaagcataca atgctgaaca cacggacaac ccaactatcc ttaactatac taaggcagac      540

ttccaacaaa tcatggtacg tttgagcgat ggacaatttg actataagat ttttgataaa      600

atcggtgttg aaacagtgat caagaaccaa ggtttggaca acttgaaagt tatcgaactt      660

ccaagcgacc aacaaccgta cgtttaccca cttcttgctc agggtcaaga tgagttgaaa      720

tcgtttgtag acaaacgcat caaagaactt tataaagatg gaactcttga aaaattgtct      780

aaacaattct tcggagacac ttatctaccg gcagaagctg atattaaaat ggccatggcc      840

gacctgaaga aggccgtgaa cgagccggag aaaccggccg aagaggagcc ggagaacccg      900

gcaccggcac ctaaacctgc acctgcaccg cagcctgaga agcctgcccc tgcaccggca      960

ccgaaaccgg agaagagcgc cgaccagcag gcagaggaag actacgcccg ccgcagcgaa     1020

gaggagtaca atcgcctgac ccagcagcaa ccgccgaagg cagaaaagcc ggccccggcc     1080

ccggttccga aacctgaaca gccggcacct gcacctaaaa caggctggaa gcaggaaaac     1140

ggcatgtggc accaccacca ccaccactga                                      1170


<210>  76
<211>  1215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP0148/H70

<400>  76
atgaaaaaaa tcgttaaata ctcatctctt gcagcccttg ctcttgttgc tgcaggtgtg       60

cttgcggctt gctcaggggg tgctaagaaa gaaggagaag cagctagcaa gaaagaaatc      120

atcgttgcaa ccaatggatc accaaagcca tttatctatg aagaaaatgg cgaattgact      180

ggttacgaga ttgaagtcgt tcgcgctatc tttaaagatt ctgacaaata tgatgtcaag      240

tttgaaaaga cagaatggtc aggtgtcttt gctggtcttg acgctgatcg ttacaatatg      300

gctgtcaaca atcttagcta cactaaagaa cgtgcggaga aatacctcta tgccgcacca      360

attgcccaaa atcctaatgt ccttgtcgtg aagaaagatg actctagtat caagtctctc      420

gatgatatcg gtggaaaatc gacggaagtc gttcaagcca ctacatcagc taagcagtta      480

gaagcataca atgctgaaca cacggacaac ccaactatcc ttaactatac taaggcagac      540

ttccaacaaa tcatggtacg tttgagcgat ggacaatttg actataagat ttttgataaa      600

atcggtgttg aaacagtgat caagaaccaa ggtttggaca acttgaaagt tatcgaactt      660

ccaagcgacc aacaaccgta cgtttaccca cttcttgctc agggtcaaga tgagttgaaa      720

tcgtttgtag acaaacgcat caaagaactt tataaagatg gaactcttga aaaattgtct      780

aaacaattct tcggagacac ttatctaccg gcagaagctg atattaaata cttcaaagag      840

ggcttagaga agaccatcgc cgccaagaag gccgagttag agaaaaccga ggccgacctg      900

aagaaagccg tgaacgagcc ggagaagcct gcacctgcac ctgaaacacc tgcccctgaa      960

gcaccggccg aacagcctaa gccggcaccg gcacctcaac ctgccccggc accgaagccg     1020

gaaaaaccgg ccgagcagcc gaaaccggag aaaaccgacg accagcaggc agaagaggac     1080

tatgcccgcc gcagcgagga agagtacaac cgcctgaccc agcagcagcc tccgaaagcc     1140

gagaaaccgg ccccggcccc gaaaaccggc tggaagcagg agaacggcat gtggcaccac     1200

caccaccacc actga                                                      1215


<210>  77
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP2108/CD2

<400>  77
atgtcatcta aatttatgaa gagcgctgcg gtgcttggaa ctgctacact tgctagcttg       60

cttttggtag cttgcggaag caaaactgct gataagcctg ctgattctgg ttcatctgaa      120

gtcaaagaac tcactgtata tgtagacgag ggatataaga gctatattga agaggttgct      180

aaagcttatg aaaaagaagc tggagtaaaa gtcactctta aaactggtga tgctctagga      240

ggtcttgata aactttctct tgacaaccaa tctggtaatg tccctgatgt tatgatggct      300

ccatacgacc gtgtaggtag ccttggttct gacggacaac tttcagaagt gaaattgagc      360

gatggtgcta aaacagacga cacaactaaa tctcttgtaa cagctgctaa tggtaaagtt      420

tacggtgctc ctgccgttat cgagtcactt gttatgtact acaacaaaga cttggtgaaa      480

gatgctccaa aaacatttgc tgacttggaa aaccttgcta aagatagcaa atacgcattc      540

gctggtgaag atggtaaaac tactgccttc ctagctgact ggacaaactt ctactataca      600

tatggacttc ttgccggtaa cggtgcttac gtctttggcc aaaacggtaa agacgctaaa      660

gacatcggtc ttgcaaacga cggttctatc gtaggtatca actacgctaa atcttggtac      720

gaaaaatggc ctaaaggtat gcaagataca gaaggtgctg gaaacttaat ccaaactcaa      780

ttccaagaag gtaaaacagc tgctatcatc gacggacctt ggaaagctca agcctttaaa      840

gatgctaaag taaactacgg agttgcaact atcccaactc ttccaaatgg aaaagaatat      900

gctgcattcg gtggtggtaa agcttgggtc attcctcaag ccgttaagaa ccttgaagct      960

tctcaaaaat ttgtagactt ccttgttgca actgaacaac aaaaagtatt atatgataag     1020

actaacgaaa tcccagctaa tactgaggct cgttcatacg ctgaaggtaa aaacgatgag     1080

ttgacaacag ctgttatcaa acagttcaag aacactcaac cactgccaaa catctctcaa     1140

atgtctgcag tttgggatcc agcgaaaaat atgctctttg atgctgtaag tggtcaaaaa     1200

gatgctaaaa cagctgctaa cgatgctgta acattgatca aagaaacaat caaacaaaaa     1260

tttggtgaaa tggccatggc cgacctgaag aaggccgtga acgagccgga gaaaccggcc     1320

gaagaggagc cggagaaccc ggcaccggca cctaaacctg cacctgcacc gcagcctgag     1380

aagcctgccc ctgcaccggc accgaaaccg gagaagagcg ccgaccagca ggcagaggaa     1440

gactacgccc gccgcagcga agaggagtac aatcgcctga cccagcagca accgccgaag     1500

gcagaaaagc cggccccggc cccggttccg aaacctgaac agccggcacc tgcacctaaa     1560

acaggctgga agcaggaaaa cggcatgtgg caccaccacc accaccactg a              1611


<210>  78
<211>  1656
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP2108/H70

<400>  78
atgtcatcta aatttatgaa gagcgctgcg gtgcttggaa ctgctacact tgctagcttg       60

cttttggtag cttgcggaag caaaactgct gataagcctg ctgattctgg ttcatctgaa      120

gtcaaagaac tcactgtata tgtagacgag ggatataaga gctatattga agaggttgct      180

aaagcttatg aaaaagaagc tggagtaaaa gtcactctta aaactggtga tgctctagga      240

ggtcttgata aactttctct tgacaaccaa tctggtaatg tccctgatgt tatgatggct      300

ccatacgacc gtgtaggtag ccttggttct gacggacaac tttcagaagt gaaattgagc      360

gatggtgcta aaacagacga cacaactaaa tctcttgtaa cagctgctaa tggtaaagtt      420

tacggtgctc ctgccgttat cgagtcactt gttatgtact acaacaaaga cttggtgaaa      480

gatgctccaa aaacatttgc tgacttggaa aaccttgcta aagatagcaa atacgcattc      540

gctggtgaag atggtaaaac tactgccttc ctagctgact ggacaaactt ctactataca      600

tatggacttc ttgccggtaa cggtgcttac gtctttggcc aaaacggtaa agacgctaaa      660

gacatcggtc ttgcaaacga cggttctatc gtaggtatca actacgctaa atcttggtac      720

gaaaaatggc ctaaaggtat gcaagataca gaaggtgctg gaaacttaat ccaaactcaa      780

ttccaagaag gtaaaacagc tgctatcatc gacggacctt ggaaagctca agcctttaaa      840

gatgctaaag taaactacgg agttgcaact atcccaactc ttccaaatgg aaaagaatat      900

gctgcattcg gtggtggtaa agcttgggtc attcctcaag ccgttaagaa ccttgaagct      960

tctcaaaaat ttgtagactt ccttgttgca actgaacaac aaaaagtatt atatgataag     1020

actaacgaaa tcccagctaa tactgaggct cgttcatacg ctgaaggtaa aaacgatgag     1080

ttgacaacag ctgttatcaa acagttcaag aacactcaac cactgccaaa catctctcaa     1140

atgtctgcag tttgggatcc agcgaaaaat atgctctttg atgctgtaag tggtcaaaaa     1200

gatgctaaaa cagctgctaa cgatgctgta acattgatca aagaaacaat caaacaaaaa     1260

tttggtgaat acttcaaaga gggcttagag aagaccatcg ccgccaagaa ggccgagtta     1320

gagaaaaccg aggccgacct gaagaaagcc gtgaacgagc cggagaagcc tgcacctgca     1380

cctgaaacac ctgcccctga agcaccggcc gaacagccta agccggcacc ggcacctcaa     1440

cctgccccgg caccgaagcc ggaaaaaccg gccgagcagc cgaaaccgga gaaaaccgac     1500

gaccagcagg cagaagagga ctatgcccgc cgcagcgagg aagagtacaa ccgcctgacc     1560

cagcagcagc ctccgaaagc cgagaaaccg gccccggccc cgaaaaccgg ctggaagcag     1620

gagaacggca tgtggcacca ccaccaccac cactga                               1656


<210>  79
<211>  1212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP0148/LC/CD2

<400>  79
atgaaaaaaa tcgttaaata ctcatctctt gcagcccttg ctcttgttgc tgcaggtgtg       60

cttgcggctt gctcaggggg tgctaagaaa gaaggagaag cagctagcaa gaaagaaatc      120

atcgttgcaa ccaatggatc accaaagcca tttatctatg aagaaaatgg cgaattgact      180

ggttacgaga ttgaagtcgt tcgcgctatc tttaaagatt ctgacaaata tgatgtcaag      240

tttgaaaaga cagaatggtc aggtgtcttt gctggtcttg acgctgatcg ttacaatatg      300

gctgtcaaca atcttagcta cactaaagaa cgtgcggaga aatacctcta tgccgcacca      360

attgcccaaa atcctaatgt ccttgtcgtg aagaaagatg actctagtat caagtctctc      420

gatgatatcg gtggaaaatc gacggaagtc gttcaagcca ctacatcagc taagcagtta      480

gaagcataca atgctgaaca cacggacaac ccaactatcc ttaactatac taaggcagac      540

ttccaacaaa tcatggtacg tttgagcgat ggacaatttg actataagat ttttgataaa      600

atcggtgttg aaacagtgat caagaaccaa ggtttggaca acttgaaagt tatcgaactt      660

ccaagcgacc aacaaccgta cgtttaccca cttcttgctc agggtcaaga tgagttgaaa      720

tcgtttgtag acaaacgcat caaagaactt tataaagatg gaactcttga aaaattgtct      780

aaacaattct tcggagacac ttatctaccg gcagaagctg atattaaagg cccgaagccg      840

caccgtatcc agagcacccc gaagggcagc atggccatgg cagacctgaa gaaggccgtg      900

aacgagccgg aaaaacctgc cgaagaggag ccggaaaatc ctgcccctgc acctaaacct      960

gcacctgccc ctcagccgga gaaaccggca cctgcaccgg cacctaagcc ggagaagagc     1020

gccgatcagc aggccgagga ggactatgcc cgtcgcagcg aagaggagta caaccgcctg     1080

acccagcaac agcctccgaa ggccgaaaaa ccggcccctg caccggtgcc taagcctgag     1140

caacctgccc cggccccgaa aaccggctgg aagcaggaaa acggcatgtg gcaccaccac     1200

caccaccact ga                                                         1212


<210>  80
<211>  1257
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP0148/LC/H70

<400>  80
atgaaaaaaa tcgttaaata ctcatctctt gcagcccttg ctcttgttgc tgcaggtgtg       60

cttgcggctt gctcaggggg tgctaagaaa gaaggagaag cagctagcaa gaaagaaatc      120

atcgttgcaa ccaatggatc accaaagcca tttatctatg aagaaaatgg cgaattgact      180

ggttacgaga ttgaagtcgt tcgcgctatc tttaaagatt ctgacaaata tgatgtcaag      240

tttgaaaaga cagaatggtc aggtgtcttt gctggtcttg acgctgatcg ttacaatatg      300

gctgtcaaca atcttagcta cactaaagaa cgtgcggaga aatacctcta tgccgcacca      360

attgcccaaa atcctaatgt ccttgtcgtg aagaaagatg actctagtat caagtctctc      420

gatgatatcg gtggaaaatc gacggaagtc gttcaagcca ctacatcagc taagcagtta      480

gaagcataca atgctgaaca cacggacaac ccaactatcc ttaactatac taaggcagac      540

ttccaacaaa tcatggtacg tttgagcgat ggacaatttg actataagat ttttgataaa      600

atcggtgttg aaacagtgat caagaaccaa ggtttggaca acttgaaagt tatcgaactt      660

ccaagcgacc aacaaccgta cgtttaccca cttcttgctc agggtcaaga tgagttgaaa      720

tcgtttgtag acaaacgcat caaagaactt tataaagatg gaactcttga aaaattgtct      780

aaacaattct tcggagacac ttatctaccg gcagaagctg atattaaagg cccgaagccg      840

caccgyatcc agagcacacc gaaaggcagc tacttcaaag agggcttaga gaagaccatc      900

gccgccaaga aggccgagtt agagaaaacc gaggccgacc tgaagaaggc cgtgaacgag      960

ccggagaaac ctgcacctgc accggagaca ccggcacctg aagcccctgc agagcagcct     1020

aaacctgccc ctgcacctca accggcacct gcacctaagc cggaaaaacc tgccgagcag     1080

ccgaagccgg agaaaaccga cgaccagcag gccgaagagg actatgcacg ccgcagcgaa     1140

gaggagtaca accgcttaac ccaacagcag ccgccgaagg cagaaaaacc ggcccctgcc     1200

cctaagaccg gttggaagca ggagaacggc atgtggcacc accaccacca ccactga        1257


<210>  81
<211>  1653
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP2108/LC/CD2

<400>  81
atgtcatcta aatttatgaa gagcgctgcg gtgcttggaa ctgctacact tgctagcttg       60

cttttggtag cttgcggaag caaaactgct gataagcctg ctgattctgg ttcatctgaa      120

gtcaaagaac tcactgtata tgtagacgag ggatataaga gctatattga agaggttgct      180

aaagcttatg aaaaagaagc tggagtaaaa gtcactctta aaactggtga tgctctagga      240

ggtcttgata aactttctct tgacaaccaa tctggtaatg tccctgatgt tatgatggct      300

ccatacgacc gtgtaggtag ccttggttct gacggacaac tttcagaagt gaaattgagc      360

gatggtgcta aaacagacga cacaactaaa tctcttgtaa cagctgctaa tggtaaagtt      420

tacggtgctc ctgccgttat cgagtcactt gttatgtact acaacaaaga cttggtgaaa      480

gatgctccaa aaacatttgc tgacttggaa aaccttgcta aagatagcaa atacgcattc      540

gctggtgaag atggtaaaac tactgccttc ctagctgact ggacaaactt ctactataca      600

tatggacttc ttgccggtaa cggtgcttac gtctttggcc aaaacggtaa agacgctaaa      660

gacatcggtc ttgcaaacga cggttctatc gtaggtatca actacgctaa atcttggtac      720

gaaaaatggc ctaaaggtat gcaagataca gaaggtgctg gaaacttaat ccaaactcaa      780

ttccaagaag gtaaaacagc tgctatcatc gacggacctt ggaaagctca agcctttaaa      840

gatgctaaag taaactacgg agttgcaact atcccaactc ttccaaatgg aaaagaatat      900

gctgcattcg gtggtggtaa agcttgggtc attcctcaag ccgttaagaa ccttgaagct      960

tctcaaaaat ttgtagactt ccttgttgca actgaacaac aaaaagtatt atatgataag     1020

actaacgaaa tcccagctaa tactgaggct cgttcatacg ctgaaggtaa aaacgatgag     1080

ttgacaacag ctgttatcaa acagttcaag aacactcaac cactgccaaa catctctcaa     1140

atgtctgcag tttgggatcc agcgaaaaat atgctctttg atgctgtaag tggtcaaaaa     1200

gatgctaaaa cagctgctaa cgatgctgta acattgatca aagaaacaat caaacaaaaa     1260

tttggtgaag gcccgaagcc gcaccgtatc cagagcaccc cgaagggcag catggccatg     1320

gcagacctga agaaggccgt gaacgagccg gaaaaacctg ccgaagagga gccggaaaat     1380

cctgcccctg cacctaaacc tgcacctgcc cctcagccgg agaaaccggc acctgcaccg     1440

gcacctaagc cggagaagag cgccgatcag caggccgagg aggactatgc ccgtcgcagc     1500

gaagaggagt acaaccgcct gacccagcaa cagcctccga aggccgaaaa accggcccct     1560

gcaccggtgc ctaagcctga gcaacctgcc ccggccccga aaaccggctg gaagcaggag     1620

aatggcatgt ggcaccacca ccaccaccac tga                                  1653


<210>  82
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP2108/LC/H70

<400>  82
atgtcatcta aatttatgaa gagcgctgcg gtgcttggaa ctgctacact tgctagcttg       60

cttttggtag cttgcggaag caaaactgct gataagcctg ctgattctgg ttcatctgaa      120

gtcaaagaac tcactgtata tgtagacgag ggatataaga gctatattga agaggttgct      180

aaagcttatg aaaaagaagc tggagtaaaa gtcactctta aaactggtga tgctctagga      240

ggtcttgata aactttctct tgacaaccaa tctggtaatg tccctgatgt tatgatggct      300

ccatacgacc gtgtaggtag ccttggttct gacggacaac tttcagaagt gaaattgagc      360

gatggtgcta aaacagacga cacaactaaa tctcttgtaa cagctgctaa tggtaaagtt      420

tacggtgctc ctgccgttat cgagtcactt gttatgtact acaacaaaga cttggtgaaa      480

gatgctccaa aaacatttgc tgacttggaa aaccttgcta aagatagcaa atacgcattc      540

gctggtgaag atggtaaaac tactgccttc ctagctgact ggacaaactt ctactataca      600

tatggacttc ttgccggtaa cggtgcttac gtctttggcc aaaacggtaa agacgctaaa      660

gacatcggtc ttgcaaacga cggttctatc gtaggtatca actacgctaa atcttggtac      720

gaaaaatggc ctaaaggtat gcaagataca gaaggtgctg gaaacttaat ccaaactcaa      780

ttccaagaag gtaaaacagc tgctatcatc gacggacctt ggaaagctca agcctttaaa      840

gatgctaaag taaactacgg agttgcaact atcccaactc ttccaaatgg aaaagaatat      900

gctgcattcg gtggtggtaa agcttgggtc attcctcaag ccgttaagaa ccttgaagct      960

tctcaaaaat ttgtagactt ccttgttgca actgaacaac aaaaagtatt atatgataag     1020

actaacgaaa tcccagctaa tactgaggct cgttcatacg ctgaaggtaa aaacgatgag     1080

ttgacaacag ctgttatcaa acagttcaag aacactcaac cactgccaaa catctctcaa     1140

atgtctgcag tttgggatcc agcgaaaaat atgctctttg atgctgtaag tggtcaaaaa     1200

gatgctaaaa cagctgctaa cgatgctgta acattgatca aagaaacaat caaacaaaaa     1260

tttggtgaag gcccgaagcc gcaccgcatc cagagcacac cgaaaggcag ctacttcaaa     1320

gagggcttag agaagaccat cgccgccaag aaggccgagt tagagaaaac cgaggccgac     1380

ctgaagaagg ccgtgaacga gccggagaaa cctgcacctg caccggagac accggcacct     1440

gaagcccctg cagagcagcc taaacctgcc cctgcacctc aaccggcacc tgcacctaag     1500

ccggaaaaac ctgccgagca gccgaagccg gagaaaaccg acgaccagca ggccgaagag     1560

gactatgcac gccgcagcga agaggagtac aaccgcttaa cccaacagca gccgccgaag     1620

gcagaaaaac cggcccctgc ccctaagacc ggttggaagc aggagaacgg catgtggcac     1680

caccaccacc accactga                                                   1698


<210>  83
<211>  1230
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP0148/LR/CD2

<400>  83
atgaaaaaaa tcgttaaata ctcatctctt gcagcccttg ctcttgttgc tgcaggtgtg       60

cttgcggctt gctcaggggg tgctaagaaa gaaggagaag cagctagcaa gaaagaaatc      120

atcgttgcaa ccaatggatc accaaagcca tttatctatg aagaaaatgg cgaattgact      180

ggttacgaga ttgaagtcgt tcgcgctatc tttaaagatt ctgacaaata tgatgtcaag      240

tttgaaaaga cagaatggtc aggtgtcttt gctggtcttg acgctgatcg ttacaatatg      300

gctgtcaaca atcttagcta cactaaagaa cgtgcggaga aatacctcta tgccgcacca      360

attgcccaaa atcctaatgt ccttgtcgtg aagaaagatg actctagtat caagtctctc      420

gatgatatcg gtggaaaatc gacggaagtc gttcaagcca ctacatcagc taagcagtta      480

gaagcataca atgctgaaca cacggacaac ccaactatcc ttaactatac taaggcagac      540

ttccaacaaa tcatggtacg tttgagcgat ggacaatttg actataagat ttttgataaa      600

atcggtgttg aaacagtgat caagaaccaa ggtttggaca acttgaaagt tatcgaactt      660

ccaagcgacc aacaaccgta cgtttaccca cttcttgctc agggtcaaga tgagttgaaa      720

tcgtttgtag acaaacgcat caaagaactt tataaagatg gaactcttga aaaattgtct      780

aaacaattct tcggagacac ttatctaccg gcagaagctg atattaaact ggccgaagca      840

accgccaaag aagccaccgc caaggaagcc acagccaagg ccaccgcaat ggccatggcc      900

gacctgaaga aggccgtgaa tgagccggag aagccggccg aagaagagcc ggagaatcct      960

gcaccggccc ctaagcctgc accggcacct cagcctgaaa aaccggcacc tgcacctgcc     1020

ccgaagcctg aaaagagcgc cgaccagcag gccgaagagg actatgcccg ccgcagcgaa     1080

gaggagtaca accgtctgac ccagcagcag ccgccgaaag ccgagaaacc tgccccggca     1140

ccggtgccta agccggaaca gcctgcccct gcaccgaaga ccggttggaa gcaggaaaac     1200

ggcatgtggc accaccacca ccaccactga                                      1230


<210>  84
<211>  1275
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP0148/LR/H70

<400>  84
atgaaaaaaa tcgttaaata ctcatctctt gcagcccttg ctcttgttgc tgcaggtgtg       60

cttgcggctt gctcaggggg tgctaagaaa gaaggagaag cagctagcaa gaaagaaatc      120

atcgttgcaa ccaatggatc accaaagcca tttatctatg aagaaaatgg cgaattgact      180

ggttacgaga ttgaagtcgt tcgcgctatc tttaaagatt ctgacaaata tgatgtcaag      240

tttgaaaaga cagaatggtc aggtgtcttt gctggtcttg acgctgatcg ttacaatatg      300

gctgtcaaca atcttagcta cactaaagaa cgtgcggaga aatacctcta tgccgcacca      360

attgcccaaa atcctaatgt ccttgtcgtg aagaaagatg actctagtat caagtctctc      420

gatgatatcg gtggaaaatc gacggaagtc gttcaagcca ctacatcagc taagcagtta      480

gaagcataca atgctgaaca cacggacaac ccaactatcc ttaactatac taaggcagac      540

ttccaacaaa tcatggtacg tttgagcgat ggacaatttg actataagat ttttgataaa      600

atcggtgttg aaacagtgat caagaaccaa ggtttggaca acttgaaagt tatcgaactt      660

ccaagcgacc aacaaccgta cgtttaccca cttcttgctc agggtcaaga tgagttgaaa      720

tcgtttgtag acaaacgcat caaagaactt tataaagatg gaactcttga aaaattgtct      780

aaacaattct tcggagacac ttatctaccg gcagaagctg atattaaact ggccgaagca      840

accgccaaag aggccaccgc caaggaagcc accgccaaag ccaccgccta cttcaaagag      900

ggcttagaga agaccatcgc cgccaagaag gccgagttag agaaaaccga ggccgacctg      960

aagaaggccg tgaacgagcc ggagaagcct gcacctgccc ctgaaacccc tgcaccggaa     1020

gcacctgcag agcagcctaa acctgcacct gcaccgcaac ctgcccctgc acctaaaccg     1080

gagaaaccgg cagagcagcc gaagccggag aaaaccgacg accagcaggc cgaggaagac     1140

tacgcccgtc gtagcgagga agagtacaac cgcctgaccc agcagcaacc gccgaaagcc     1200

gaaaagccgg cccctgcacc gaaaaccggc tggaagcagg agaacggcat gtggcaccac     1260

caccaccacc actga                                                      1275


<210>  85
<211>  1671
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP2108/LR/CD2

<400>  85
atgtcatcta aatttatgaa gagcgctgcg gtgcttggaa ctgctacact tgctagcttg       60

cttttggtag cttgcggaag caaaactgct gataagcctg ctgattctgg ttcatctgaa      120

gtcaaagaac tcactgtata tgtagacgag ggatataaga gctatattga agaggttgct      180

aaagcttatg aaaaagaagc tggagtaaaa gtcactctta aaactggtga tgctctagga      240

ggtcttgata aactttctct tgacaaccaa tctggtaatg tccctgatgt tatgatggct      300

ccatacgacc gtgtaggtag ccttggttct gacggacaac tttcagaagt gaaattgagc      360

gatggtgcta aaacagacga cacaactaaa tctcttgtaa cagctgctaa tggtaaagtt      420

tacggtgctc ctgccgttat cgagtcactt gttatgtact acaacaaaga cttggtgaaa      480

gatgctccaa aaacatttgc tgacttggaa aaccttgcta aagatagcaa atacgcattc      540

gctggtgaag atggtaaaac tactgccttc ctagctgact ggacaaactt ctactataca      600

tatggacttc ttgccggtaa cggtgcttac gtctttggcc aaaacggtaa agacgctaaa      660

gacatcggtc ttgcaaacga cggttctatc gtaggtatca actacgctaa atcttggtac      720

gaaaaatggc ctaaaggtat gcaagataca gaaggtgctg gaaacttaat ccaaactcaa      780

ttccaagaag gtaaaacagc tgctatcatc gacggacctt ggaaagctca agcctttaaa      840

gatgctaaag taaactacgg agttgcaact atcccaactc ttccaaatgg aaaagaatat      900

gctgcattcg gtggtggtaa agcttgggtc attcctcaag ccgttaagaa ccttgaagct      960

tctcaaaaat ttgtagactt ccttgttgca actgaacaac aaaaagtatt atatgataag     1020

actaacgaaa tcccagctaa tactgaggct cgttcatacg ctgaaggtaa aaacgatgag     1080

ttgacaacag ctgttatcaa acagttcaag aacactcaac cactgccaaa catctctcaa     1140

atgtctgcag tttgggatcc agcgaaaaat atgctctttg atgctgtaag tggtcaaaaa     1200

gatgctaaaa cagctgctaa cgatgctgta acattgatca aagaaacaat caaacaaaaa     1260

tttggtgaac tggccgaggc aaccgccaaa gaagccaccg ccaaggaagc cacagccaag     1320

gccaccgcaa tggccatggc cgacctgaag aaggccgtga atgagccgga gaagccggcc     1380

gaagaagagc cggagaatcc tgcaccggcc cctaagcctg caccggcacc tcagcctgaa     1440

aaaccggcac ctgcacctgc cccgaagcct gaaaagagcg ccgaccagca ggccgaagag     1500

gactatgccc gccgcagcga agaggagtac aaccgtctga cccagcagca gccgccgaaa     1560

gccgagaaac ctgccccggc accggtgcct aagccggaac agcctgcccc tgcaccgaag     1620

accggttgga agcaggaraa cggcatgtgg caccaccacc accaccactg a              1671


<210>  86
<211>  1716
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP2108/LR/H70

<400>  86
atgtcatcta aatttatgaa gagcgctgcg gtgcttggaa ctgctacact tgctagcttg       60

cttttggtag cttgcggaag caaaactgct gataagcctg ctgattctgg ttcatctgaa      120

gtcaaagaac tcactgtata tgtagacgag ggatataaga gctatattga agaggttgct      180

aaagcttatg aaaaagaagc tggagtaaaa gtcactctta aaactggtga tgctctagga      240

ggtcttgata aactttctct tgacaaccaa tctggtaatg tccctgatgt tatgatggct      300

ccatacgacc gtgtaggtag ccttggttct gacggacaac tttcagaagt gaaattgagc      360

gatggtgcta aaacagacga cacaactaaa tctcttgtaa cagctgctaa tggtaaagtt      420

tacggtgctc ctgccgttat cgagtcactt gttatgtact acaacaaaga cttggtgaaa      480

gatgctccaa aaacatttgc tgacttggaa aaccttgcta aagatagcaa atacgcattc      540

gctggtgaag atggtaaaac tactgccttc ctagctgact ggacaaactt ctactataca      600

tatggacttc ttgccggtaa cggtgcttac gtctttggcc aaaacggtaa agacgctaaa      660

gacatcggtc ttgcaaacga cggttctatc gtaggtatca actacgctaa atcttggtac      720

gaaaaatggc ctaaaggtat gcaagataca gaaggtgctg gaaacttaat ccaaactcaa      780

ttccaagaag gtaaaacagc tgctatcatc gacggacctt ggaaagctca agcctttaaa      840

gatgctaaag taaactacgg agttgcaact atcccaactc ttccaaatgg aaaagaatat      900

gctgcattcg gtggtggtaa agcttgggtc attcctcaag ccgttaagaa ccttgaagct      960

tctcaaaaat ttgtagactt ccttgttgca actgaacaac aaaaagtatt atatgataag     1020

actaacgaaa tcccagctaa tactgaggct cgttcatacg ctgaaggtaa aaacgatgag     1080

ttgacaacag ctgttatcaa acagttcaag aacactcaac cactgccaaa catctctcaa     1140

atgtctgcag tttgggatcc agcgaaaaat atgctctttg atgctgtaag tggtcaaaaa     1200

gatgctaaaa cagctgctaa cgatgctgta acattgatca aagaaacaat caaacaaaaa     1260

tttggtgaac tggccgaagc aaccgccaaa gaggccaccg ccaaggaagc caccgccaaa     1320

gccaccgcct acttcaaaga gggcttagag aagaccatcg ccgccaagaa ggccgagtta     1380

gagaaaaccg aggccgacct gaagaaggcc gtgaacgagc cggagaagcc tgcacctgcc     1440

cctgaaaccc ctgcaccgga agcacctgca gagcagccta aacctgcacc tgcaccgcaa     1500

cctgcccctg cacctaaacc ggagaaaccg gcagagcagc cgaagccgga gaaaaccgac     1560

gaccagcagg ccgaggaaga ctacgcccgt cgtagcgagg aagagtacaa ccgcctgacc     1620

cagcagcaac cgccgaaagc cgaaaagccg gcccctgcac cgaaaaccgg ctggaagcag     1680

gagaacggca tgtggcacca ccaccaccac cactga                               1716


<210>  87
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6xHis tag

<400>  87

His His His His His His 
1               5       


<210>  88
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Histidine tag

<400>  88

Met Ser Tyr Tyr His His His His His His 
1               5                   10  


<210>  89
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Canonical lipobox motif


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Leu, Ile, Val, Met, Phe, Glu, Ser, Thr, Ala, Gly, Pro or Cys

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Leu, Val, Ile, Ala, Met, Phe, Thr or Gly

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Ile, Val, Met, Ser, Thr, Ala, Gly, Cys or Pro

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Ala, Gly or Ser

<400>  89

Xaa Xaa Xaa Xaa Cys 
1               5   


<210>  90
<211>  25
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  90

Met Ser Ser Lys Phe Met Lys Ser Ala Ala Val Leu Gly Thr Ala Thr 
1               5                   10                  15      


Leu Ala Ser Leu Leu Leu Val Ala Cys 
            20                  25  


<210>  91
<211>  19
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  May or may not be present

<400>  91

Met Arg Tyr Leu Ala Thr Leu Leu Leu Ser Leu Ala Val Leu Ile Thr 
1               5                   10                  15      


Ala Gly Cys 
            


<210>  92
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein linker

<400>  92

Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Ala Ala Ala 
            


<210>  93
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein LR linker

<400>  93

Leu Ala Glu Ala Thr Ala Lys Glu Ala Thr Ala Lys Glu Ala Thr Ala 
1               5                   10                  15      


Lys Ala Thr Ala 
            20  


<210>  94
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein LC linker

<400>  94

Gly Pro Lys Pro His Arg Ile Gln Ser Thr Pro Lys Gly Ser 
1               5                   10                  


<210>  95
<211>  8
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  95

Asp Leu Lys Lys Ala Val Asn Glu 
1               5               


<210>  96
<211>  11
<212>  PRT
<213>  Streptococcus pneumoniae


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Lys or Gly

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Lys or Gly

<400>  96

Xaa Thr Gly Trp Xaa Gln Glu Asn Gly Met Trp 
1               5                   10      


<210>  97
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  97

Ala Leu Gly Leu Val Ala Ala Gly Val 
1               5                   


<210>  98
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  98

Glu Leu Thr Gly Tyr Glu Ile Glu Val 
1               5                   


<210>  99
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  99

Ala Val Asn Asn Leu Ser Tyr Thr Lys 
1               5                   


<210>  100
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  100

Thr Tyr Leu Pro Ala Glu Ala Asp Ile 
1               5                   


<210>  101
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  101

Arg Tyr Asn Met Ala Val Asn Asn Leu 
1               5                   


<210>  102
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  102

Asp Phe Gln Gln Ile Met Val Arg Leu 
1               5                   


<210>  103
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  103

Glu His Thr Asp Asn Pro Thr Ile Leu 
1               5                   


<210>  104
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  104

Ala Pro Ile Ala Gln Asn Pro Asn Val 
1               5                   


<210>  105
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  105

Leu Pro Ser Asp Gln Gln Pro Tyr Val 
1               5                   


<210>  106
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  106

Tyr Val Tyr Pro Leu Leu Ala Gln Gly 
1               5                   


<210>  107
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  107

Gln Gly Leu Asp Asn Leu Lys Val Ile 
1               5                   


<210>  108
<211>  8
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  108

Lys Tyr Leu Tyr Ala Ala Pro Ile 
1               5               


<210>  109
<211>  8
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  109

Gly Glu Leu Thr Gly Tyr Glu Ile 
1               5               


<210>  110
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  110

Asn Pro Asn Val Leu Val Val Lys Lys 
1               5                   


<210>  111
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  111

Lys Leu Ser Lys Gln Phe Phe Gly Asp 
1               5                   


<210>  112
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  112

Gly Ser Pro Arg Pro Phe Ile Tyr Glu 
1               5                   


<210>  113
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  113

Ala Val Asn Asn Leu Ser Tyr Thr Lys 
1               5                   


<210>  114
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  114

Lys Ile Phe Asp Lys Ile Gly Val Glu 
1               5                   


<210>  115
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  115

Met Val Arg Leu Ser Asp Gly Gln Phe 
1               5                   


<210>  116
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  116

Tyr Val Tyr Pro Leu Leu Ala Gln Gly 
1               5                   


<210>  117
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  117

Val Val Gln Ala Thr Thr Ser Ala Lys 
1               5                   


<210>  118
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  118

Thr Leu Glu Lys Leu Ser Lys Gln Phe 
1               5                   


<210>  119
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  119

Val Ala Ala Gly Val Leu Ala Ala Cys 
1               5                   


<210>  120
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  120

Leu Asp Asn Leu Lys Val Ile Glu Leu 
1               5                   


<210>  121
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  121

Asn Met Ala Val Asn Asn Leu Ser Tyr 
1               5                   


<210>  122
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  122

Ala Ile Ile Asp Gly Pro Trp Lys Ala 
1               5                   


<210>  123
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  123

Val Met Met Ala Pro Tyr Asp Arg Val 
1               5                   


<210>  124
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  124

Ser Ile Ala Gly Ile Asn Tyr Ala Lys 
1               5                   


<210>  125
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  125

Val Trp Asp Pro Ala Lys Asn Met Leu 
1               5                   


<210>  126
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  126

Gln Pro Leu Pro Asn Ile Ser Gln Met 
1               5                   


<210>  127
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  127

Ala Pro Tyr Asp Arg Val Gly Ser Leu 
1               5                   


<210>  128
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  128

Ala Pro Ala Val Ile Glu Ser Leu Val 
1               5                   


<210>  129
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  129

Phe Tyr Tyr Thr Tyr Gly Leu Leu Ala 
1               5                   


<210>  130
<211>  8
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  130

Ser Lys Tyr Ala Phe Ala Gly Glu 
1               5               


<210>  131
<211>  8
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  131

Thr Glu Gly Ala Gly Asn Leu Ile 
1               5               


<210>  132
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  132

Leu Ala Asp Trp Thr Asn Phe Tyr Tyr 
1               5                   


<210>  133
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  133

Ser Leu Val Met Tyr Tyr Asn Lys Asp 
1               5                   


<210>  134
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  134

Lys Glu Ala Gly Val Lys Val Thr Leu 
1               5                   


<210>  135
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  135

Lys Ser Thr Ala Val Leu Gly Thr Val 
1               5                   


<210>  136
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  136

Gly Ala Lys Thr Asp Asp Thr Thr Lys 
1               5                   


<210>  137
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  137

Ser Gln Lys Phe Val Asp Phe Leu Val 
1               5                   


<210>  138
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  138

Gln Ala Phe Lys Asp Ala Lys Val Asn 
1               5                   


<210>  139
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  139

Ala Val Ile Glu Ser Leu Val Met Tyr 
1               5                   


<210>  140
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  140

Asp Ala Lys Thr Ala Ala Asn Asp Ala 
1               5                   


<210>  141
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  141

Tyr Gly Val Ala Thr Ile Pro Thr Leu 
1               5                   


<210>  142
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  142

Lys Thr Ala Ala Ile Ile Asp Gly Pro 
1               5                   


<210>  143
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  143

Lys Ala Tyr Glu Lys Glu Ala Gly Val 
1               5                   


<210>  144
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  144

Ala Gly Asn Gly Ala Tyr Val Phe Gly 
1               5                   


<210>  145
<211>  9
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  145

Ala Trp Val Ile Pro Gln Ala Val Lys 
1               5                   


<210>  146
<211>  15
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  146

Lys Met Trp Met Ala Gly Leu Ala Leu Leu Gly Ile Gly Ser Leu 
1               5                   10                  15  


<210>  147
<211>  15
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  147

Leu Leu Gly Ile Gly Ser Leu Ala Leu Ala Thr Lys Lys Val Ala 
1               5                   10                  15  


<210>  148
<211>  15
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  148

Met Ala Gly Leu Ala Leu Leu Gly Ile Gly Ser Leu Ala Leu Ala 
1               5                   10                  15  


<210>  149
<211>  15
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  149

Trp Met Ala Gly Leu Ala Leu Leu Gly Ile Gly Ser Leu Ala Leu 
1               5                   10                  15  


<210>  150
<211>  15
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  150

Gly Leu Ala Leu Leu Gly Ile Gly Ser Leu Ala Leu Ala Thr Lys 
1               5                   10                  15  


<210>  151
<211>  15
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  151

Leu Ala Leu Leu Gly Ile Gly Ser Leu Ala Leu Ala Thr Lys Lys 
1               5                   10                  15  


<210>  152
<211>  15
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  152

Phe Ser Asp Met Gly Glu Ile Ala Thr Leu Tyr Val Gln Val Tyr 
1               5                   10                  15  


<210>  153
<211>  15
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  153

Lys Ala Lys Lys Met Trp Met Ala Gly Leu Ala Leu Leu Gly Ile 
1               5                   10                  15  


<210>  154
<211>  17
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  154

Ala Leu Leu Gly Ile Gly Ser Leu Ala Leu Ala Thr Lys Lys Val Ala 
1               5                   10                  15      


Lys 
    


<210>  155
<211>  15
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  155

Ser Asp Met Gly Glu Ile Ala Thr Leu Tyr Val Gln Val Tyr Glu 
1               5                   10                  15  


<210>  156
<211>  15
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  156

Asp Met Gly Glu Ile Ala Thr Leu Tyr Val Gln Val Tyr Glu Ser 
1               5                   10                  15  


<210>  157
<211>  15
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  157

Ala Gly Leu Ala Leu Leu Gly Ile Gly Ser Leu Ala Leu Ala Thr 
1               5                   10                  15  


<210>  158
<211>  15
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  158

Met Gly Glu Ile Ala Thr Leu Tyr Val Gln Val Tyr Glu Ser Ser 
1               5                   10                  15  


<210>  159
<211>  15
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  159

Lys Lys Met Trp Met Ala Gly Leu Ala Leu Leu Gly Ile Gly Ser 
1               5                   10                  15  


<210>  160
<211>  15
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  160

Gly Met Lys Ala Lys Lys Met Trp Met Ala Gly Leu Ala Leu Leu 
1               5                   10                  15  


<210>  161
<211>  15
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  161

Met Lys Ala Lys Lys Met Trp Met Ala Gly Leu Ala Leu Leu Gly 
1               5                   10                  15  


<210>  162
<211>  15
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  162

His Phe Ser Asp Met Gly Glu Ile Ala Thr Leu Tyr Val Gln Val 
1               5                   10                  15  


<210>  163
<211>  15
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  163

Met Asn Gly Met Lys Ala Lys Lys Met Trp Met Ala Gly Leu Ala 
1               5                   10                  15  


<210>  164
<211>  15
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  164

Met Trp Met Ala Gly Leu Ala Leu Leu Gly Ile Gly Ser Leu Ala 
1               5                   10                  15  


<210>  165
<211>  15
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  165

Asp His Phe Ser Asp Met Gly Glu Ile Ala Thr Leu Tyr Val Gln 
1               5                   10                  15  


<210>  166
<211>  15
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  166

Arg Asp His Phe Ser Asp Met Gly Glu Ile Ala Thr Leu Tyr Val 
1               5                   10                  15  


<210>  167
<211>  15
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  167

Asn Gly Met Lys Ala Lys Lys Met Trp Met Ala Gly Leu Ala Leu 
1               5                   10                  15  


<210>  168
<211>  13
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  168

Lys Met Trp Met Ala Gly Leu Ala Leu Leu Gly Ile Gly 
1               5                   10              


