                         SEQUENCE LISTING

<110>  ImmuVen, Inc.
       Smith, Sheena N.
       Kranz, David M.
 
<120>  ENGINEERING T-CELL RECEPTORS

<130>  IMMU-002/01WO

<150>  US 61/676,373
<151>  2012-07-27

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Thr Thr Asp Ser Trp 
                85                  90                  95      


Gly Lys Leu Gln Phe Gly Ala Gly Thr Gln Val Val Val Thr Pro Asp 
            100                 105                 110         


Ile 
    


<210>  2
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  2

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro Asn Gly Tyr 
    50                  55                  60                  


Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Leu Ala Gly Gly Arg Pro Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr Glu Asp Leu Lys Asn 
        115                 120 


<210>  3
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  3

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ala Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Val Gly Ile Thr Asp Gln Gly Asp Val Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Leu Met Ser Ala Gln Pro Glu Leu Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr Glu Asp Leu Ile Asn Gly Ser Ala Asp Asp Ala Lys Lys 
        115                 120                 125             


Asp Ala Ala Lys Lys Asp Gly Lys Ser Gln Lys Glu Val Glu Gln Asn 
    130                 135                 140                 


Ser Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys 
145                 150                 155                 160 


Thr Tyr Ser Asp Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr 
                165                 170                 175     


Ser Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp 
            180                 185                 190         


Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr 
        195                 200                 205             


Val Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr 
    210                 215                 220                 


Leu Cys Ala Val Thr Thr Asp Ser Trp Gly Lys Leu Gln Phe Gly Ala 
225                 230                 235                 240 


Gly Thr Gln Val Val Val Thr Pro Asp Ile 
                245                 250 


<210>  4
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized amino acid sequence of the RD1 library


<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  Xaa = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (168)..(168)
<223>  Xaa = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (230)..(230)
<223>  Xaa = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (231)..(231)
<223>  Xaa = Any amino acid

<400>  4

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ala Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Val Gly Ile Thr Asp Gln Gly Asp Val Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Xaa Met Ser Xaa Gln Pro Glu Leu Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr Glu Asp Leu Ile Asn Gly Ser Ala Asp Asp Ala Lys Lys 
        115                 120                 125             


Asp Ala Ala Lys Lys Asp Gly Lys Ser Gln Lys Glu Val Glu Gln Asn 
    130                 135                 140                 


Ser Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys 
145                 150                 155                 160 


Thr Tyr Ser Asp Arg Gly Ser Xaa Ser Phe Phe Trp Tyr Arg Gln Tyr 
                165                 170                 175     


Ser Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp 
            180                 185                 190         


Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr 
        195                 200                 205             


Val Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr 
    210                 215                 220                 


Leu Cys Ala Val Thr Xaa Xaa Ser Trp Gly Lys Leu Gln Phe Gly Ala 
225                 230                 235                 240 


Gly Thr Gln Val Val Val Thr Pro Asp Ile 
                245                 250 


<210>  5
<211>  9
<212>  PRT
<213>  Human T cell lymphotrophic virus

<400>  5

Leu Leu Phe Gly Tyr Pro Val Tyr Val 
1               5                   


<210>  6
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   


<210>  7
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  7

Glu Leu Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  8
<211>  9
<212>  PRT
<213>  Human immunodeficiency virus

<400>  8

Ser Leu Tyr Asn Thr Val Ala Thr Leu 
1               5                   


<210>  9
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  9

Arg Met Phe Pro Asn Ala Pro Tyr Leu 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  10

Leu Thr Leu Gly Glu Phe Leu Lys Leu 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  11

Ser Leu Leu Met Trp Ile Thr Gln Cys 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  12

Ala Leu Trp Gly Pro Asp Ala Ala Ala 
1               5                   


<210>  13
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  13

Val Leu Phe Tyr Leu Gly Gln Tyr 
1               5               


<210>  14
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  14

Phe Leu Leu Thr Arg Ile Leu Thr Ile 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  15

Lys Thr Trp Gly Gln Tyr Trp Gln Val 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  16

Ser Thr Ala Pro Pro Val His Asn Val 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  17

Phe Leu Trp Gly Pro Arg Ala Leu Val 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  18

Lys Ile Phe Gly Ser Leu Ala Phe Leu 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  19

Leu Glu Glu Lys Lys Gly Asn Tyr Val 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  20

Tyr Leu Ser Gly Ala Asn Leu Asn Leu 
1               5                   


<210>  21
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  21

Gly Ser Ala Asp Asp Ala Lys Lys Asp Ala Ala Lys Lys Asp Gly Lys 
1               5                   10                  15      


Ser 
    


<210>  22
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone from RD1 library

<400>  22

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ala Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Val Gly Ile Thr Asp Gln Gly Asp Val Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Ile Met Ser Glu Gln Pro Glu Leu Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr Glu Asp Leu Ile Asn Gly Ser Ala Asp Asp Ala Lys Lys 
        115                 120                 125             


Asp Ala Ala Lys Lys Asp Gly Lys Ser Gln Lys Glu Val Glu Gln Asn 
    130                 135                 140                 


Ser Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys 
145                 150                 155                 160 


Thr Tyr Ser Asp Arg Gly Ser Ser Ser Phe Phe Trp Tyr Arg Gln Tyr 
                165                 170                 175     


Ser Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp 
            180                 185                 190         


Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr 
        195                 200                 205             


Val Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr 
    210                 215                 220                 


Leu Cys Ala Val Thr Pro Pro Ser Trp Gly Lys Leu Gln Phe Gly Ala 
225                 230                 235                 240 


Gly Thr Gln Val Val Val Thr Pro Asp Ile 
                245                 250 


<210>  23
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone from RD1 library

<400>  23

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ala Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Val Gly Ile Thr Asp Gln Gly Asp Val Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Arg Met Ser Met Gln Pro Glu Leu Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr Glu Asp Leu Ile Asn Gly Ser Ala Asp Asp Ala Lys Lys 
        115                 120                 125             


Asp Ala Ala Lys Lys Asp Gly Lys Ser Gln Lys Glu Val Glu Gln Asn 
    130                 135                 140                 


Ser Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys 
145                 150                 155                 160 


Thr Tyr Ser Asp Arg Gly Ser Arg Ser Phe Phe Trp Tyr Arg Gln Tyr 
                165                 170                 175     


Ser Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp 
            180                 185                 190         


Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr 
        195                 200                 205             


Val Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr 
    210                 215                 220                 


Leu Cys Ala Val Thr Pro Cys Ser Trp Gly Lys Leu Gln Phe Gly Ala 
225                 230                 235                 240 


Gly Thr Gln Val Val Val Thr Pro Asp Ile 
                245                 250 


<210>  24
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone from RD1 library

<400>  24

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ala Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Val Gly Ile Thr Asp Gln Gly Asp Val Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Ser Met Ser Ala Gln Pro Glu Leu Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr Glu Asp Leu Ile Asn Gly Ser Ala Asp Asp Ala Lys Lys 
        115                 120                 125             


Asp Ala Ala Lys Lys Asp Gly Lys Ser Gln Lys Glu Val Glu Gln Asn 
    130                 135                 140                 


Ser Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys 
145                 150                 155                 160 


Thr Tyr Ser Asp Arg Gly Ser Ala Ser Phe Phe Trp Tyr Arg Gln Tyr 
                165                 170                 175     


Ser Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp 
            180                 185                 190         


Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr 
        195                 200                 205             


Val Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr 
    210                 215                 220                 


Leu Cys Ala Val Thr Ile Val Ser Trp Gly Lys Leu Gln Phe Gly Ala 
225                 230                 235                 240 


Gly Thr Gln Val Val Val Thr Pro Asp Ile 
                245                 250 


<210>  25
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone from RD1 library

<400>  25

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ala Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Val Gly Ile Thr Asp Gln Gly Asp Val Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Thr Met Ser Arg Gln Pro Glu Leu Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr Glu Asp Leu Ile Asn Gly Ser Ala Asp Asp Ala Lys Lys 
        115                 120                 125             


Asp Ala Ala Lys Lys Asp Gly Lys Ser Gln Lys Glu Val Glu Gln Asn 
    130                 135                 140                 


Ser Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys 
145                 150                 155                 160 


Thr Tyr Ser Asp Arg Gly Ser Gly Ser Phe Phe Trp Tyr Arg Gln Tyr 
                165                 170                 175     


Ser Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp 
            180                 185                 190         


Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr 
        195                 200                 205             


Val Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr 
    210                 215                 220                 


Leu Cys Ala Val Thr Ser Leu Ser Trp Gly Lys Leu Gln Phe Gly Ala 
225                 230                 235                 240 


Gly Thr Gln Val Val Val Thr Pro Asp Ile 
                245                 250 


<210>  26
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone from RD1 library

<400>  26

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ala Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Val Gly Ile Thr Asp Gln Gly Asp Val Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Ser Met Ser His Gln Pro Glu Leu Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr Glu Asp Leu Ile Asn Gly Ser Ala Asp Asp Ala Lys Lys 
        115                 120                 125             


Asp Ala Ala Lys Lys Asp Gly Lys Ser Gln Lys Glu Val Glu Gln Asn 
    130                 135                 140                 


Ser Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys 
145                 150                 155                 160 


Thr Tyr Ser Asp Arg Gly Ser Phe Ser Phe Phe Trp Tyr Arg Gln Tyr 
                165                 170                 175     


Ser Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp 
            180                 185                 190         


Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr 
        195                 200                 205             


Val Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr 
    210                 215                 220                 


Leu Cys Ala Val Thr Leu His Ser Trp Gly Lys Leu Gln Phe Gly Ala 
225                 230                 235                 240 


Gly Thr Gln Val Val Val Thr Pro Asp Ile 
                245                 250 


<210>  27
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone from RD1 library

<400>  27

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ala Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Val Gly Ile Thr Asp Gln Gly Asp Val Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Ala Met Ser Gln Pro Glu Leu Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
            100                 105                 110         


Val Thr Glu Asp Leu Ile Asn Gly Ser Ala Asp Asp Ala Lys Lys Asp 
        115                 120                 125             


Ala Ala Lys Lys Asp Gly Lys Ser Gln Lys Glu Val Glu Gln Asn Ser 
    130                 135                 140                 


Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr 
145                 150                 155                 160 


Tyr Ser Asp Arg Gly Ser Tyr Ser Phe Phe Trp Tyr Arg Gln Tyr Ser 
                165                 170                 175     


Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp Lys 
            180                 185                 190         


Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val 
        195                 200                 205             


Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu 
    210                 215                 220                 


Cys Ala Val Thr Asn Phe Ser Trp Gly Lys Leu Gln Phe Gly Ala Gly 
225                 230                 235                 240 


Thr Gln Val Val Val Thr Pro Asp Ile 
                245                 


<210>  28
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone from RD1 library

<400>  28

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ala Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Val Gly Ile Thr Asp Gln Gly Asp Val Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Ser Met Ser Arg Gln Pro Glu Leu Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr Glu Asp Leu Ile Asn Gly Ser Ala Asp Asp Ala Lys Lys 
        115                 120                 125             


Asp Ala Ala Lys Lys Asp Gly Lys Ser Gln Lys Glu Val Glu Gln Asn 
    130                 135                 140                 


Ser Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys 
145                 150                 155                 160 


Thr Tyr Ser Asp Arg Gly Ser Ala Ser Phe Phe Trp Tyr Arg Gln Tyr 
                165                 170                 175     


Ser Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp 
            180                 185                 190         


Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr 
        195                 200                 205             


Val Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr 
    210                 215                 220                 


Leu Cys Ala Val Thr Arg Thr Ser Trp Gly Lys Leu Gln Phe Gly Ala 
225                 230                 235                 240 


Gly Thr Gln Val Val Val Thr Pro Asp Ile 
                245                 250 


<210>  29
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone from RD1 library

<400>  29

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ala Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Val Gly Ile Thr Asp Gln Gly Asp Val Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Arg Met Ser Gln Gln Pro Glu Leu Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr Glu Asp Leu Ile Asn Gly Ser Ala Asp Asp Ala Lys Lys 
        115                 120                 125             


Asp Ala Ala Lys Lys Asp Gly Lys Ser Gln Lys Glu Val Glu Gln Asn 
    130                 135                 140                 


Ser Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys 
145                 150                 155                 160 


Thr Tyr Ser Asp Arg Gly Ser Trp Ser Phe Phe Trp Tyr Arg Gln Tyr 
                165                 170                 175     


Ser Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp 
            180                 185                 190         


Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr 
        195                 200                 205             


Val Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr 
    210                 215                 220                 


Leu Cys Ala Val Thr Ser Cys Ser Trp Gly Lys Leu Gln Phe Gly Ala 
225                 230                 235                 240 


Gly Thr Gln Val Val Val Thr Pro Asp Ile 
                245                 250 


<210>  30
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone from RD1 library

<400>  30

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ala Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Val Gly Ile Thr Asp Gln Gly Asp Val Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Tyr Met Ser Pro Gln Pro Glu Leu Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr Glu Asp Leu Ile Asn Gly Ser Ala Asp Asp Ala Lys Lys 
        115                 120                 125             


Asp Ala Ala Lys Lys Asp Gly Lys Ser Gln Lys Glu Val Glu Gln Asn 
    130                 135                 140                 


Ser Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys 
145                 150                 155                 160 


Thr Tyr Ser Asp Arg Gly Ser Asn Ser Phe Phe Trp Tyr Arg Gln Tyr 
                165                 170                 175     


Ser Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp 
            180                 185                 190         


Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr 
        195                 200                 205             


Val Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr 
    210                 215                 220                 


Leu Cys Ala Val Thr Phe Leu Ser Trp Gly Lys Leu Gln Phe Gly Ala 
225                 230                 235                 240 


Gly Thr Gln Val Val Val Thr Pro Asp Ile 
                245                 250 


<210>  31
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone from RD1 library

<400>  31

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ala Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Val Gly Ile Thr Asp Gln Gly Asp Val Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Leu Met Ser Leu Gln Pro Glu Leu Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr Glu Asp Leu Ile Asn Gly Ser Ala Asp Asp Ala Lys Lys 
        115                 120                 125             


Asp Ala Ala Lys Lys Asp Gly Lys Ser Gln Lys Glu Val Glu Gln Asn 
    130                 135                 140                 


Ser Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys 
145                 150                 155                 160 


Thr Tyr Ser Asp Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr 
                165                 170                 175     


Ser Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp 
            180                 185                 190         


Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr 
        195                 200                 205             


Val Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr 
    210                 215                 220                 


Leu Cys Ala Val Thr Arg Ala Ser Trp Gly Lys Leu Gln Phe Gly Ala 
225                 230                 235                 240 


Gly Thr Gln Val Val Val Thr Pro Asp Ile 
                245                 250 


<210>  32
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RD1-Tax-S4-1 clone sequence

<400>  32

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ala Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Val Gly Ile Thr Asp Gln Gly Asp Val Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Leu Met Ser Ala Gln Pro Glu Leu Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr Glu Asp Leu Ile Asn Gly Ser Ala Asp Asp Ala Lys Lys 
        115                 120                 125             


Asp Ala Ala Lys Lys Asp Gly Lys Ser Gln Lys Glu Val Glu Gln Asn 
    130                 135                 140                 


Ser Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys 
145                 150                 155                 160 


Thr Tyr Ser Asp Arg Gly Ser Thr Ser Phe Phe Trp Tyr Arg Gln Tyr 
                165                 170                 175     


Ser Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp 
            180                 185                 190         


Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr 
        195                 200                 205             


Val Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr 
    210                 215                 220                 


Leu Cys Ala Val Thr Thr Asp Ser Trp Gly Lys Leu Gln Phe Gly Ala 
225                 230                 235                 240 


Gly Thr Gln Val Val Val Thr Pro Asp Ile 
                245                 250 


<210>  33
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RD1-Mart1-S5-5 clone sequence

<400>  33

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ala Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Val Gly Ile Thr Asp Gln Gly Asp Val Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Trp Met Ser Gly Gln Pro Glu Leu Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr Glu Asp Leu Ile Asn Gly Ser Ala Asp Asp Ala Lys Lys 
        115                 120                 125             


Asp Ala Ala Lys Lys Asp Gly Lys Ser Gln Lys Glu Val Glu Gln Asn 
    130                 135                 140                 


Ser Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys 
145                 150                 155                 160 


Thr Tyr Ser Asp Arg Gly Ser Thr Ser Phe Phe Trp Tyr Arg Gln Tyr 
                165                 170                 175     


Ser Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp 
            180                 185                 190         


Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr 
        195                 200                 205             


Val Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr 
    210                 215                 220                 


Leu Cys Ala Val Thr Lys Tyr Ser Trp Gly Lys Leu Gln Phe Gly Ala 
225                 230                 235                 240 


Gly Thr Gln Val Val Val Thr Pro Asp Ile 
                245                 250 


<210>  34
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RD1-Mart1-High clone sequence

<400>  34

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ala Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Val Gly Ile Thr Asp Gln Gly Asp Val Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Trp Met Ala Gly Gly Val Glu Leu Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr Glu Asp Leu Ile Asn Gly Ser Ala Asp Asp Ala Lys Lys 
        115                 120                 125             


Asp Ala Ala Lys Lys Asp Gly Lys Ser Gln Lys Glu Val Glu Gln Asn 
    130                 135                 140                 


Ser Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys 
145                 150                 155                 160 


Thr Tyr Ser Asp Arg Gly Ser Thr Ser Phe Phe Trp Tyr Arg Gln Tyr 
                165                 170                 175     


Ser Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp 
            180                 185                 190         


Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr 
        195                 200                 205             


Val Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr 
    210                 215                 220                 


Leu Cys Ala Val Thr Lys Tyr Ser Trp Gly Lys Leu Gln Phe Gly Ala 
225                 230                 235                 240 


Gly Thr Gln Val Val Val Thr Pro Asp Ile 
                245                 250 


<210>  35
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Degenerate amino acid sequence for RD2 library


<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  Xaa = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  Xaa = Ala or Met

<220>
<221>  MISC_FEATURE
<222>  (99)..(99)
<223>  Xaa = Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  Xaa = Gly or Ala

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  Xaa = Arg or Gln

<220>
<221>  MISC_FEATURE
<222>  (163)..(163)
<223>  Xaa = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (165)..(165)
<223>  Xaa = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (167)..(167)
<223>  Xaa = Gln or Thr

<220>
<221>  MISC_FEATURE
<222>  (231)..(231)
<223>  Xaa = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (232)..(232)
<223>  Xaa = Any amino acid

<400>  35

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ala Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Val Gly Ile Thr Asp Gln Gly Asp Val Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Pro Glu Leu Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr Glu Asp Leu Ile Asn Gly Ser Ala Asp Asp Ala Lys Lys 
        115                 120                 125             


Asp Ala Ala Lys Lys Asp Gly Lys Ser Lys Glu Val Glu Gln Asn Ser 
    130                 135                 140                 


Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr 
145                 150                 155                 160 


Tyr Ser Xaa Arg Xaa Ser Xaa Ser Phe Phe Trp Tyr Arg Gln Tyr Ser 
                165                 170                 175     


Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp Lys 
            180                 185                 190         


Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val 
        195                 200                 205             


Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu 
    210                 215                 220                 


Cys Ala Val Thr Thr Asp Xaa Xaa Gly Lys Leu Gln Phe Gly Ala Gly 
225                 230                 235                 240 


Thr Gln Val Val Val Thr Pro Asp Ile 
                245                 


<210>  36
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone from RD2 library

<400>  36

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ala Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Val Gly Ile Thr Asp Gln Gly Asp Val Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Leu Met Ser Ala Gln Pro Glu Leu Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr Glu Asp Leu Ile Asn Gly Ser Ala Asp Asp Ala Lys Lys 
        115                 120                 125             


Asp Ala Ala Lys Lys Asp Gly Lys Ser Lys Glu Val Glu Gln Asn Ser 
    130                 135                 140                 


Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr 
145                 150                 155                 160 


Tyr Ser Cys Arg Met Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser 
                165                 170                 175     


Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp Lys 
            180                 185                 190         


Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val 
        195                 200                 205             


Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu 
    210                 215                 220                 


Cys Ala Val Thr Thr Asp Tyr Ser Gly Lys Leu Gln Phe Gly Ala Gly 
225                 230                 235                 240 


Thr Gln Val Val Val Thr Pro Asp Ile 
                245                 


<210>  37
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone from RD2 library

<400>  37

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ala Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Val Gly Ile Thr Asp Gln Gly Asp Val Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Asp Ala Gly Gly Arg Pro Glu Leu Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr Glu Asp Leu Ile Asn Gly Ser Ala Asp Asp Ala Lys Lys 
        115                 120                 125             


Asp Ala Ala Lys Lys Asp Gly Lys Ser Lys Glu Val Glu Gln Asn Ser 
    130                 135                 140                 


Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr 
145                 150                 155                 160 


Tyr Ser Pro Arg Arg Ser Thr Ser Phe Phe Trp Tyr Arg Gln Tyr Ser 
                165                 170                 175     


Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp Lys 
            180                 185                 190         


Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val 
        195                 200                 205             


Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu 
    210                 215                 220                 


Cys Ala Val Thr Thr Asp Thr Asn Gly Lys Leu Gln Phe Gly Ala Gly 
225                 230                 235                 240 


Thr Gln Val Val Val Thr Pro Asp Ile 
                245                 


<210>  38
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone from RD2 library

<400>  38

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ala Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Val Gly Ile Thr Asp Gln Gly Asp Val Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Cys Met Ser Ala Gln Pro Glu Leu Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr Glu Asp Leu Ile Asn Gly Ser Ala Asp Asp Ala Lys Lys 
        115                 120                 125             


Asp Ala Ala Lys Lys Asp Gly Lys Ser Lys Glu Val Glu Gln Asn Ser 
    130                 135                 140                 


Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr 
145                 150                 155                 160 


Tyr Ser Cys Arg Phe Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser 
                165                 170                 175     


Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp Lys 
            180                 185                 190         


Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val 
        195                 200                 205             


Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu 
    210                 215                 220                 


Cys Ala Val Thr Thr Asp Glu Val Gly Lys Leu Gln Phe Gly Ala Gly 
225                 230                 235                 240 


Thr Gln Val Val Val Thr Pro Asp Ile 
                245                 


<210>  39
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone from RD2 library

<400>  39

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ala Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Val Gly Ile Thr Asp Gln Gly Asp Val Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Leu Met Ser Ala Gln Pro Glu Leu Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr Glu Asp Leu Ile Asn Gly Ser Ala Asp Asp Ala Lys Lys 
        115                 120                 125             


Asp Ala Ala Lys Lys Asp Gly Lys Ser Lys Glu Val Glu Gln Asn Ser 
    130                 135                 140                 


Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr 
145                 150                 155                 160 


Tyr Ser Thr Arg Tyr Ser Thr Ser Phe Phe Trp Tyr Arg Gln Tyr Ser 
                165                 170                 175     


Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp Lys 
            180                 185                 190         


Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val 
        195                 200                 205             


Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu 
    210                 215                 220                 


Cys Ala Val Thr Thr Asp Pro Leu Gly Lys Leu Gln Phe Gly Ala Gly 
225                 230                 235                 240 


Thr Gln Val Val Val Thr Pro Asp Ile 
                245                 


<210>  40
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone from RD2 library

<400>  40

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ala Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Val Gly Ile Thr Asp Gln Gly Asp Val Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Arg Ala Gly Gly Arg Pro Glu Leu Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr Glu Asp Leu Ile Asn Gly Ser Ala Asp Asp Ala Lys Lys 
        115                 120                 125             


Asp Ala Ala Lys Lys Asp Gly Lys Ser Lys Glu Val Glu Gln Asn Ser 
    130                 135                 140                 


Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr 
145                 150                 155                 160 


Tyr Ser Asn Arg Ser Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser 
                165                 170                 175     


Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp Lys 
            180                 185                 190         


Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val 
        195                 200                 205             


Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu 
    210                 215                 220                 


Cys Ala Val Thr Thr Asp Asn His Gly Lys Leu Gln Phe Gly Ala Gly 
225                 230                 235                 240 


Thr Gln Val Val Val Thr Pro Asp Ile 
                245                 


<210>  41
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RD2-Mart1-S3-3 clone sequence

<400>  41

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ala Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Val Gly Ile Thr Asp Gln Gly Asp Val Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Met Ala Gly Gly Arg Pro Glu Leu Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr Glu Asp Leu Ile Asn Gly Ser Ala Asp Asp Ala Lys Lys 
        115                 120                 125             


Asp Ala Ala Lys Lys Asp Gly Lys Ser Lys Glu Val Glu Gln Asn Ser 
    130                 135                 140                 


Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr 
145                 150                 155                 160 


Tyr Ser Ser Arg His Ser Thr Ser Phe Ser Trp Tyr Arg Gln Tyr Pro 
                165                 170                 175     


Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp Lys 
            180                 185                 190         


Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val 
        195                 200                 205             


Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu 
    210                 215                 220                 


Cys Ala Val Thr Thr Asp Arg Ser Gly Lys Leu Gln Phe Gly Ala Gly 
225                 230                 235                 240 


Thr Gln Val Val Val Thr Pro Asp Ile 
                245                 


<210>  42
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RD2-Mart1-S3-4 clone sequence

<400>  42

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ala Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Val Gly Ile Thr Asp Gln Gly Asp Val Pro Asp Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Pro Gly 
                85                  90                  95      


Met Ala Gly Gly Arg Pro Glu Leu Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr Glu Asp Leu Ile Asn Gly Ser Ala Asp Asp Ala Lys Lys 
        115                 120                 125             


Asp Ala Ala Lys Lys Asp Gly Lys Ser Lys Glu Val Glu Gln Asn Ser 
    130                 135                 140                 


Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr 
145                 150                 155                 160 


Tyr Ser Ser Arg His Ser Gln Ser Phe Ser Trp Tyr Arg Gln Tyr Pro 
                165                 170                 175     


Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp Lys 
            180                 185                 190         


Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val 
        195                 200                 205             


Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu 
    210                 215                 220                 


Cys Ala Val Thr Thr Asp Leu Trp Gly Lys Leu Gln Phe Gly Ala Gly 
225                 230                 235                 240 


Thr Gln Val Val Val Thr Pro Asp Ile 
                245                 


<210>  43
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone T1-S18.45 amino acid sequence

<400>  43

Glu Ala Gly Val Thr Gln Phe Pro Ser His Ser Val Ile Glu Lys Gly 
1               5                   10                  15      


Gln Thr Val Thr Leu Arg Cys Asp Pro Ile Ser Gly His Asp Asn Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Arg Val Met Gly Lys Glu Ile Lys Phe Leu Leu His 
        35                  40                  45              


Phe Val Lys Glu Ser Lys Gln Asp Glu Ser Gly Met Pro Asn Asn Arg 
    50                  55                  60                  


Phe Leu Ala Glu Arg Thr Gly Gly Thr Tyr Ser Thr Leu Lys Ile Gln 
65                  70                  75                  80  


Pro Ala Glu Leu Glu Asp Ser Gly Val Tyr Phe Cys Ala Ser Ser His 
                85                  90                  95      


Ala Gly Leu Gly Val Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
            100                 105                 110         


Val Thr Glu Asp Leu Lys Asn Gly Ser Ala Asp Asp Ala Lys Glu Asp 
        115                 120                 125             


Ala Ala Lys Lys Asp Gly Lys Ser Gln Lys Glu Val Glu Gln Asn Ser 
    130                 135                 140                 


Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr 
145                 150                 155                 160 


Tyr Ser Asp Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Pro 
                165                 170                 175     


Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp Lys 
            180                 185                 190         


Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val 
        195                 200                 205             


Ser Leu Leu Ile Arg Asp Ser Arg Pro Ser Asp Ser Ala Thr Tyr Leu 
    210                 215                 220                 


Cys Ala Val Ser Ser Ser Asp Phe Leu Met Phe Gly Asp Gly Thr Gln 
225                 230                 235                 240 


Leu Val Val Lys Pro Asn Ile 
                245         


<210>  44
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  44

Ala Gly Gly Arg 
1               


<210>  45
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ser Ala Gln 
1               


<210>  46
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  46

Ala Ser Asn Glu Asn Met Asp Ala Met 
1               5                   


<210>  47
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  47

Ala Ser Asn Glu Asn Met Glu Thr Met 
1               5                   


<210>  48
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' region of RD1 gene optimized for yeast and E. coli

<400>  48
tctgctagc                                                                9


<210>  49
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' region of RD1 gene optimized for yeast and E.coli

<400>  49
ctcgagatct ga                                                           12


<210>  50
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer used to add pCT302 overhangs

<400>  50
caggctagtg gtggtggtgg ttctggtggt ggtggttctg gtggtggtgg ttctgctagc       60

aatgctggtg taacacaaac gccaa                                             85


<210>  51
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer used to add pCT302 overhangs

<400>  51
ggaacaaagt cgattttgtt acatctacac tgttgttaac agatctcgag tcattataaa       60

tcttcttcag agatc                                                        75


<210>  52
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer to generate the CDR3 1 library (Splice 4L)

<400>  52
ggcagcccca taaacacaca gtat                                              24


<210>  53
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer to generate a CDR3 1 library (Splice 4L)

<400>  53
cggacgggaa gcgcagaaat acactgaggt ttgagaaggt gcagcgctta acagacgcag       60

cgg                                                                     63


<210>  54
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer to generate a CDR3 1 library (T7)


<220>
<221>  misc_feature
<222>  (31)..(32)
<223>  n = A, T, C or G

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  n = A, T, C or G

<220>
<221>  misc_feature
<222>  (37)..(38)
<223>  n = A, T, C or G

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  n = A, T, C or G

<220>
<221>  misc_feature
<222>  (43)..(44)
<223>  n = A, T, C or G

<400>  54
acctcagtgt atttctgcgc ttcccgtccg nnknnknnkn nknnkcagcc tgaactgtac       60

tttggtccag gcactaga                                                     78


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer to generate a CDR3 1 library (T7)

<400>  55
taatacgact cactataggg                                                   20


<210>  56
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer to generate a CDR3 2 library

<400>  56
cggacgggaa gcgcagaaat acactgaggt ttgagaaggt gcagcgctta acagacgcag       60

cgg                                                                     63


<210>  57
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to generate a CDR3beta2 library


<220>
<221>  misc_feature
<222>  (37)..(38)
<223>  n = a, t, g or c

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  n = a, t, g or c

<220>
<221>  misc_feature
<222>  (43)..(44)
<223>  n = a, t, g or c

<220>
<221>  misc_feature
<222>  (46)..(47)
<223>  n = a, t, g or c

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  n = a, t, g or c

<400>  57
acctcagtgt atttctgcgc ttcccgtccg ggttggnnkn nknnknnknn kgaactgtac       60

tttggtccag gcactagact gaccg                                             85


<210>  58
<211>  71
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to generate a CDR3alpha  library

<400>  58
cgtaaccgcg cacaagtatg tggccgaatc ggaaggctgg gagtcacgaa tcagcaaact       60

aacatactgg c                                                            71


<210>  59
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to generate a CDR3alpha  library


<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  n = a, t, c or g

<220>
<221>  misc_feature
<222>  (37)..(38)
<223>  n = a, t, c or g

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  n = a, t, c or g

<220>
<221>  misc_feature
<222>  (43)..(44)
<223>  n = a, t, c or g

<220>
<221>  misc_feature
<222>  (46)..(47)
<223>  n = a, t, c or g

<400>  59
tccgattcgg ccacatactt gtgcgcggtt acgnnknnkn nknnknnkaa actgcaattt       60

ggtgcgggca cccaggttgt gg                                                82


<210>  60
<211>  150
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Flanking N-terminal DNA  from yeast codon optimized RD2 gene

<400>  60
ggcagcccca taaacacaca gtatgttttt aaggacaata gctcgacgat tgaaggtaga       60

tacccatacg acgttccaga ctacgctctg caggctagtg gtggtggtgg ttctggtggt      120

ggtggttctg gtggtggtgg ttctgctagc                                       150


<210>  61
<211>  346
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Flanking C-terminal DNA  from yeast codon optimized RD2 gene

<400>  61
ctcgagatct gttaacaaca gtgtagatgt aacaaaatcg actttgttcc cactgtactt       60

ttagctcgta caaaatacaa tatacttttc atttctccgt aaacaacatg ttttcccatg      120

taatatcctt ttctattttt cgttccgtta ccaactttac acatacttta tatagctatt      180

cacttctata cactaaaaaa ctaagacaat tttaattttg ctgcctgcca tatttcaatt      240

tgttataaat tcctataatt tatcctatta gtagctaaaa aaagatgaat gtgaatcgaa      300

tcctaagaga attgagctcc aattcgccct atagtgagtc gtatta                     346


