                               SEQUENCE LISTING

<110> JOSLIN DIABETES CENTER, INC.
 
<120> PREDICTING AND TREATING DIABETIC COMPLICATIONS

<130> JDP-160WO01

<140> PCT/US2013/052249
<141> 2013-07-26

<150> 61/676,057
<151> 2012-07-26

<160> 11    

<170> PatentIn version 3.5

<210> 1
<211> 154
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Thr Lys Ala Val Cys Val Leu Lys Gly Asp Gly Pro Val Gln 
1               5                   10                  15      


Gly Ile Ile Asn Phe Glu Gln Lys Glu Ser Asn Gly Pro Val Lys Val 
            20                  25                  30          


Trp Gly Ser Ile Lys Gly Leu Thr Glu Gly Leu His Gly Phe His Val 
        35                  40                  45              


His Glu Phe Gly Asp Asn Thr Ala Gly Cys Thr Ser Ala Gly Pro His 
    50                  55                  60                  


Phe Asn Pro Leu Ser Arg Lys His Gly Gly Pro Lys Asp Glu Glu Arg 
65                  70                  75                  80  


His Val Gly Asp Leu Gly Asn Val Thr Ala Asp Lys Asp Gly Val Ala 
                85                  90                  95      


Asp Val Ser Ile Glu Asp Ser Val Ile Ser Leu Ser Gly Asp His Cys 
            100                 105                 110         


Ile Ile Gly Arg Thr Leu Val Val His Glu Lys Ala Asp Asp Leu Gly 
        115                 120                 125             


Lys Gly Gly Asn Glu Glu Ser Thr Lys Thr Gly Asn Ala Gly Ser Arg 
    130                 135                 140                 


Leu Ala Cys Gly Val Ile Gly Ile Ala Gln 
145                 150                 


<210> 2
<211> 249
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Pro Ser Arg Lys Phe Phe Val Gly Gly Asn Trp Lys Met Asn 
1               5                   10                  15      


Gly Arg Lys Gln Ser Leu Gly Glu Leu Ile Gly Thr Leu Asn Ala Ala 
            20                  25                  30          


Lys Val Pro Ala Asp Thr Glu Val Val Cys Ala Pro Pro Thr Ala Tyr 
        35                  40                  45              


Ile Asp Phe Ala Arg Gln Lys Leu Asp Pro Lys Ile Ala Val Ala Ala 
    50                  55                  60                  


Gln Asn Cys Tyr Lys Val Thr Asn Gly Ala Phe Thr Gly Glu Ile Ser 
65                  70                  75                  80  


Pro Gly Met Ile Lys Asp Cys Gly Ala Thr Trp Val Val Arg Gly His 
                85                  90                  95      


Ser Glu Arg Arg His Val Phe Gly Glu Ser Asp Glu Leu Ile Gly Gln 
            100                 105                 110         


Lys Val Ala His Ala Leu Ala Glu Gly Leu Gly Val Ile Ala Cys Ile 
        115                 120                 125             


Gly Glu Lys Leu Asp Glu Arg Glu Ala Gly Ile Thr Glu Lys Val Val 
    130                 135                 140                 


Phe Glu Gln Thr Lys Val Ile Ala Asp Asn Val Lys Asp Trp Ser Lys 
145                 150                 155                 160 


Val Val Leu Ala Tyr Glu Pro Val Trp Ala Ile Gly Thr Gly Lys Thr 
                165                 170                 175     


Ala Thr Pro Gln Gln Ala Gln Glu Val His Glu Lys Leu Arg Gly Trp 
            180                 185                 190         


Leu Lys Ser Asn Val Ser Asp Ala Val Ala Gln Ser Thr Arg Ile Ile 
        195                 200                 205             


Tyr Gly Gly Ser Val Thr Gly Ala Thr Cys Lys Glu Leu Ala Ser Gln 
    210                 215                 220                 


Pro Asp Val Asp Gly Phe Leu Val Gly Gly Ala Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Phe Val Asp Ile Ile Asn Ala Lys Gln 
                245                 


<210> 3
<211> 357
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Ala Ala Ala Lys Pro Asn Asn Leu Ser Leu Val Val His Gly 
1               5                   10                  15      


Pro Gly Asp Leu Arg Leu Glu Asn Tyr Pro Ile Pro Glu Pro Gly Pro 
            20                  25                  30          


Asn Glu Val Leu Leu Arg Met His Ser Val Gly Ile Cys Gly Ser Asp 
        35                  40                  45              


Val His Tyr Trp Glu Tyr Gly Arg Ile Gly Asn Phe Ile Val Lys Lys 
    50                  55                  60                  


Pro Met Val Leu Gly His Glu Ala Ser Gly Thr Val Glu Lys Val Gly 
65                  70                  75                  80  


Ser Ser Val Lys His Leu Lys Pro Gly Asp Arg Val Ala Ile Glu Pro 
                85                  90                  95      


Gly Ala Pro Arg Glu Asn Asp Glu Phe Cys Lys Met Gly Arg Tyr Asn 
            100                 105                 110         


Leu Ser Pro Ser Ile Phe Phe Cys Ala Thr Pro Pro Asp Asp Gly Asn 
        115                 120                 125             


Leu Cys Arg Phe Tyr Lys His Asn Ala Ala Phe Cys Tyr Lys Leu Pro 
    130                 135                 140                 


Asp Asn Val Thr Phe Glu Glu Gly Ala Leu Ile Glu Pro Leu Ser Val 
145                 150                 155                 160 


Gly Ile His Ala Cys Arg Arg Gly Gly Val Thr Leu Gly His Lys Val 
                165                 170                 175     


Leu Val Cys Gly Ala Gly Pro Ile Gly Met Val Thr Leu Leu Val Ala 
            180                 185                 190         


Lys Ala Met Gly Ala Ala Gln Val Val Val Thr Asp Leu Ser Ala Thr 
        195                 200                 205             


Arg Leu Ser Lys Ala Lys Glu Ile Gly Ala Asp Leu Val Leu Gln Ile 
    210                 215                 220                 


Ser Lys Glu Ser Pro Gln Glu Ile Ala Arg Lys Val Glu Gly Gln Leu 
225                 230                 235                 240 


Gly Cys Lys Pro Glu Val Thr Ile Glu Cys Thr Gly Ala Glu Ala Ser 
                245                 250                 255     


Ile Gln Ala Gly Ile Tyr Ala Thr Arg Ser Gly Gly Asn Leu Val Leu 
            260                 265                 270         


Val Gly Leu Gly Ser Glu Met Thr Thr Val Pro Leu Leu His Ala Ala 
        275                 280                 285             


Ile Arg Glu Val Asp Ile Lys Gly Val Phe Arg Tyr Cys Asn Thr Trp 
    290                 295                 300                 


Pro Val Ala Ile Ser Met Leu Ala Ser Lys Ser Val Asn Val Lys Pro 
305                 310                 315                 320 


Leu Val Thr His Arg Phe Pro Leu Glu Lys Ala Leu Glu Ala Phe Glu 
                325                 330                 335     


Thr Phe Lys Lys Gly Leu Gly Leu Lys Ile Met Leu Lys Cys Asp Pro 
            340                 345                 350         


Ser Asp Gln Asn Pro 
        355         


<210> 4
<211> 418
<212> PRT
<213> Homo sapiens

<400> 4
Met Ala Arg Arg Lys Pro Glu Gly Ser Ser Phe Asn Met Thr His Leu 
1               5                   10                  15      


Ser Met Ala Met Ala Phe Ser Phe Pro Pro Val Ala Ser Gly Gln Leu 
            20                  25                  30          


His Pro Gln Leu Gly Asn Thr Gln His Gln Thr Glu Leu Gly Lys Glu 
        35                  40                  45              


Leu Ala Thr Thr Ser Thr Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro 
    50                  55                  60                  


Glu Gln Lys Lys Glu Leu Ser Asp Ile Ala His Arg Ile Val Ala Pro 
65                  70                  75                  80  


Gly Lys Gly Ile Leu Ala Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys 
                85                  90                  95      


Arg Leu Gln Ser Ile Gly Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe 
            100                 105                 110         


Tyr Arg Gln Leu Leu Leu Thr Ala Asp Asp Arg Val Asn Pro Cys Ile 
        115                 120                 125             


Gly Gly Val Ile Leu Phe His Glu Thr Leu Tyr Gln Lys Ala Asp Asp 
    130                 135                 140                 


Gly Arg Pro Phe Pro Gln Val Ile Lys Ser Lys Gly Gly Val Val Gly 
145                 150                 155                 160 


Ile Lys Val Asp Lys Gly Val Val Pro Leu Ala Gly Thr Asn Gly Glu 
                165                 170                 175     


Thr Thr Thr Gln Gly Leu Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr 
            180                 185                 190         


Lys Lys Asp Gly Ala Asp Phe Ala Lys Trp Arg Cys Val Leu Lys Ile 
        195                 200                 205             


Gly Glu His Thr Pro Ser Ala Leu Ala Ile Met Glu Asn Ala Asn Val 
    210                 215                 220                 


Leu Ala Arg Tyr Ala Ser Ile Cys Gln Gln Asn Gly Ile Val Pro Ile 
225                 230                 235                 240 


Val Glu Pro Glu Ile Leu Pro Asp Gly Asp His Asp Leu Lys Arg Cys 
                245                 250                 255     


Gln Tyr Val Thr Glu Lys Val Leu Ala Ala Val Tyr Lys Ala Leu Ser 
            260                 265                 270         


Asp His His Ile Tyr Leu Glu Gly Thr Leu Leu Lys Pro Asn Met Val 
        275                 280                 285             


Thr Pro Gly His Ala Cys Thr Gln Lys Phe Ser His Glu Glu Ile Ala 
    290                 295                 300                 


Met Ala Thr Val Thr Ala Leu Arg Arg Thr Val Pro Pro Ala Val Thr 
305                 310                 315                 320 


Gly Ile Thr Phe Leu Ser Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile 
                325                 330                 335     


Asn Leu Asn Ala Ile Asn Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu 
            340                 345                 350         


Thr Phe Ser Tyr Gly Arg Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp 
        355                 360                 365             


Gly Gly Lys Lys Glu Asn Leu Lys Ala Ala Gln Glu Glu Tyr Val Lys 
    370                 375                 380                 


Arg Ala Leu Ala Asn Ser Leu Ala Cys Gln Gly Lys Tyr Thr Pro Ser 
385                 390                 395                 400 


Gly Gln Ala Gly Ala Ala Ala Ser Glu Ser Leu Phe Val Ser Asn His 
                405                 410                 415     


Ala Tyr 
        


<210> 5
<211> 335
<212> PRT
<213> Homo sapiens

<400> 5
Met Gly Lys Val Lys Val Gly Val Asn Gly Phe Gly Arg Ile Gly Arg 
1               5                   10                  15      


Leu Val Thr Arg Ala Ala Phe Asn Ser Gly Lys Val Asp Ile Val Ala 
            20                  25                  30          


Ile Asn Asp Pro Phe Ile Asp Leu Asn Tyr Met Val Tyr Met Phe Gln 
        35                  40                  45              


Tyr Asp Ser Thr His Gly Lys Phe His Gly Thr Val Lys Ala Glu Asn 
    50                  55                  60                  


Gly Lys Leu Val Ile Asn Gly Asn Pro Ile Thr Ile Phe Gln Glu Arg 
65                  70                  75                  80  


Asp Pro Ser Lys Ile Lys Trp Gly Asp Ala Gly Ala Glu Tyr Val Val 
                85                  90                  95      


Glu Ser Thr Gly Val Phe Thr Thr Met Glu Lys Ala Gly Ala His Leu 
            100                 105                 110         


Gln Gly Gly Ala Lys Arg Val Ile Ile Ser Ala Pro Ser Ala Asp Ala 
        115                 120                 125             


Pro Met Phe Val Met Gly Val Asn His Glu Lys Tyr Asp Asn Ser Leu 
    130                 135                 140                 


Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Leu 
145                 150                 155                 160 


Ala Lys Val Ile His Asp Asn Phe Gly Ile Val Glu Gly Leu Met Thr 
                165                 170                 175     


Thr Val His Ala Ile Thr Ala Thr Gln Lys Thr Val Asp Gly Pro Ser 
            180                 185                 190         


Gly Lys Leu Trp Arg Asp Gly Arg Gly Ala Leu Gln Asn Ile Ile Pro 
        195                 200                 205             


Ala Ser Thr Gly Ala Ala Lys Ala Val Gly Lys Val Ile Pro Glu Leu 
    210                 215                 220                 


Asn Gly Lys Leu Thr Gly Met Ala Phe Arg Val Pro Thr Ala Asn Val 
225                 230                 235                 240 


Ser Val Val Asp Leu Thr Cys Arg Leu Glu Lys Pro Ala Lys Tyr Asp 
                245                 250                 255     


Asp Ile Lys Lys Val Val Lys Gln Ala Ser Glu Gly Pro Leu Lys Gly 
            260                 265                 270         


Ile Leu Gly Tyr Thr Glu His Gln Val Val Ser Ser Asp Phe Asn Ser 
        275                 280                 285             


Asp Thr His Ser Ser Thr Phe Asp Ala Gly Ala Gly Ile Ala Leu Asn 
    290                 295                 300                 


Asp His Phe Val Lys Leu Ile Ser Trp Tyr Asp Asn Glu Phe Gly Tyr 
305                 310                 315                 320 


Ser Asn Arg Val Val Asp Leu Met Ala His Met Ala Ser Lys Glu 
                325                 330                 335 


<210> 6
<211> 531
<212> PRT
<213> Homo sapiens

<400> 6
Met Ser Lys Pro His Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln 
1               5                   10                  15      


Gln Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg 
            20                  25                  30          


Leu Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile 
        35                  40                  45              


Cys Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Thr Leu Lys Glu Met 
    50                  55                  60                  


Ile Lys Ser Gly Met Asn Val Ala Arg Leu Asn Phe Ser His Gly Thr 
65                  70                  75                  80  


His Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Thr Ala Thr Glu 
                85                  90                  95      


Ser Phe Ala Ser Asp Pro Ile Leu Tyr Arg Pro Val Ala Val Ala Leu 
            100                 105                 110         


Asp Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly 
        115                 120                 125             


Thr Ala Glu Val Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu 
    130                 135                 140                 


Asp Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp 
145                 150                 155                 160 


Tyr Lys Asn Ile Cys Lys Val Val Glu Val Gly Ser Lys Ile Tyr Val 
                165                 170                 175     


Asp Asp Gly Leu Ile Ser Leu Gln Val Lys Gln Lys Gly Ala Asp Phe 
            180                 185                 190         


Leu Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly Ser Lys Lys Gly 
        195                 200                 205             


Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys 
    210                 215                 220                 


Asp Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val 
225                 230                 235                 240 


Phe Ala Ser Phe Ile Arg Lys Ala Ser Asp Val His Glu Val Arg Lys 
                245                 250                 255     


Val Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu 
            260                 265                 270         


Asn His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp 
        275                 280                 285             


Gly Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu 
    290                 295                 300                 


Lys Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg Cys Asn Arg Ala 
305                 310                 315                 320 


Gly Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys 
                325                 330                 335     


Lys Pro Arg Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val 
            340                 345                 350         


Leu Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly 
        355                 360                 365             


Asp Tyr Pro Leu Glu Ala Val Arg Met Gln His Leu Ile Ala Arg Glu 
    370                 375                 380                 


Ala Glu Ala Ala Ile Tyr His Leu Gln Leu Phe Glu Glu Leu Arg Arg 
385                 390                 395                 400 


Leu Ala Pro Ile Thr Ser Asp Pro Thr Glu Ala Thr Ala Val Gly Ala 
                405                 410                 415     


Val Glu Ala Ser Phe Lys Cys Cys Ser Gly Ala Ile Ile Val Leu Thr 
            420                 425                 430         


Lys Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala 
        435                 440                 445             


Pro Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala Arg Gln Ala His 
    450                 455                 460                 


Leu Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp Pro Val Gln Glu 
465                 470                 475                 480 


Ala Trp Ala Glu Asp Val Asp Leu Arg Val Asn Phe Ala Met Asn Val 
                485                 490                 495     


Gly Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu 
            500                 505                 510         


Thr Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val 
        515                 520                 525             


Pro Val Pro 
    530     


<210> 7
<211> 434
<212> PRT
<213> Homo sapiens

<400> 7
Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys 
    50                  55                  60                  


Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu 
                85                  90                  95      


Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala 
                165                 170                 175     


Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu 
            180                 185                 190         


Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser 
            260                 265                 270         


Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp 
    290                 295                 300                 


Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu 
            420                 425                 430         


Ala Lys 
        


<210> 8
<211> 491
<212> PRT
<213> Homo sapiens

<400> 8
Met Lys Arg Met Val Ser Trp Ser Phe His Lys Leu Lys Thr Met Lys 
1               5                   10                  15      


His Leu Leu Leu Leu Leu Leu Cys Val Phe Leu Val Lys Ser Gln Gly 
            20                  25                  30          


Val Asn Asp Asn Glu Glu Gly Phe Phe Ser Ala Arg Gly His Arg Pro 
        35                  40                  45              


Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser Leu Arg Pro Ala Pro Pro 
    50                  55                  60                  


Pro Ile Ser Gly Gly Gly Tyr Arg Ala Arg Pro Ala Lys Ala Ala Ala 
65                  70                  75                  80  


Thr Gln Lys Lys Val Glu Arg Lys Ala Pro Asp Ala Gly Gly Cys Leu 
                85                  90                  95      


His Ala Asp Pro Asp Leu Gly Val Leu Cys Pro Thr Gly Cys Gln Leu 
            100                 105                 110         


Gln Glu Ala Leu Leu Gln Gln Glu Arg Pro Ile Arg Asn Ser Val Asp 
        115                 120                 125             


Glu Leu Asn Asn Asn Val Glu Ala Val Ser Gln Thr Ser Ser Ser Ser 
    130                 135                 140                 


Phe Gln Tyr Met Tyr Leu Leu Lys Asp Leu Trp Gln Lys Arg Gln Lys 
145                 150                 155                 160 


Gln Val Lys Asp Asn Glu Asn Val Val Asn Glu Tyr Ser Ser Glu Leu 
                165                 170                 175     


Glu Lys His Gln Leu Tyr Ile Asp Glu Thr Val Asn Ser Asn Ile Pro 
            180                 185                 190         


Thr Asn Leu Arg Val Leu Arg Ser Ile Leu Glu Asn Leu Arg Ser Lys 
        195                 200                 205             


Ile Gln Lys Leu Glu Ser Asp Val Ser Ala Gln Met Glu Tyr Cys Arg 
    210                 215                 220                 


Thr Pro Cys Thr Val Ser Cys Asn Ile Pro Val Val Ser Gly Lys Glu 
225                 230                 235                 240 


Cys Glu Glu Ile Ile Arg Lys Gly Gly Glu Thr Ser Glu Met Tyr Leu 
                245                 250                 255     


Ile Gln Pro Asp Ser Ser Val Lys Pro Tyr Arg Val Tyr Cys Asp Met 
            260                 265                 270         


Asn Thr Glu Asn Gly Gly Trp Thr Val Ile Gln Asn Arg Gln Asp Gly 
        275                 280                 285             


Ser Val Asp Phe Gly Arg Lys Trp Asp Pro Tyr Lys Gln Gly Phe Gly 
    290                 295                 300                 


Asn Val Ala Thr Asn Thr Asp Gly Lys Asn Tyr Cys Gly Leu Pro Gly 
305                 310                 315                 320 


Glu Tyr Trp Leu Gly Asn Asp Lys Ile Ser Gln Leu Thr Arg Met Gly 
                325                 330                 335     


Pro Thr Glu Leu Leu Ile Glu Met Glu Asp Trp Lys Gly Asp Lys Val 
            340                 345                 350         


Lys Ala His Tyr Gly Gly Phe Thr Val Gln Asn Glu Ala Asn Lys Tyr 
        355                 360                 365             


Gln Ile Ser Val Asn Lys Tyr Arg Gly Thr Ala Gly Asn Ala Leu Met 
    370                 375                 380                 


Asp Gly Ala Ser Gln Leu Met Gly Glu Asn Arg Thr Met Thr Ile His 
385                 390                 395                 400 


Asn Gly Met Phe Phe Ser Thr Tyr Asp Arg Asp Asn Asp Gly Trp Leu 
                405                 410                 415     


Thr Ser Asp Pro Arg Lys Gln Cys Ser Lys Glu Asp Gly Gly Gly Trp 
            420                 425                 430         


Trp Tyr Asn Arg Cys His Ala Ala Asn Pro Asn Gly Arg Tyr Tyr Trp 
        435                 440                 445             


Gly Gly Gln Tyr Thr Trp Asp Met Ala Lys His Gly Thr Asp Asp Gly 
    450                 455                 460                 


Val Val Trp Met Asn Trp Lys Gly Ser Trp Tyr Ser Met Arg Lys Met 
465                 470                 475                 480 


Ser Met Lys Ile Arg Pro Phe Phe Pro Gln Gln 
                485                 490     


<210> 9
<211> 489
<212> PRT
<213> Homo sapiens

<400> 9
Leu Thr Pro Ala Gln Gln Thr Arg Arg Asp Gln Ser Val Pro Val Gly 
1               5                   10                  15      


Ser Met Ala Thr Lys Cys Gly Asn Cys Gly Pro Gly Tyr Ser Thr Pro 
            20                  25                  30          


Leu Glu Ala Met Lys Gly Pro Arg Glu Glu Ile Val Tyr Leu Pro Cys 
        35                  40                  45              


Ile Tyr Arg Asn Thr Gly Thr Glu Ala Pro Asp Tyr Leu Ala Thr Val 
    50                  55                  60                  


Asp Val Asp Pro Lys Ser Pro Gln Tyr Cys Gln Val Ile His Arg Leu 
65                  70                  75                  80  


Pro Met Pro Asn Leu Lys Asp Glu Leu His His Ser Gly Trp Asn Thr 
                85                  90                  95      


Cys Ser Ser Cys Phe Gly Asp Ser Thr Lys Ser Arg Thr Lys Leu Val 
            100                 105                 110         


Leu Pro Ser Leu Ile Ser Ser Arg Ile Tyr Val Val Asp Val Gly Ser 
        115                 120                 125             


Glu Pro Arg Ala Pro Lys Leu His Lys Val Ile Glu Pro Lys Asp Ile 
    130                 135                 140                 


His Ala Lys Cys Glu Leu Ala Phe Leu His Thr Ser His Cys Leu Ala 
145                 150                 155                 160 


Ser Gly Glu Val Met Ile Ser Ser Leu Gly Asp Val Lys Gly Asn Gly 
                165                 170                 175     


Lys Gly Gly Phe Val Leu Leu Asp Gly Glu Thr Phe Glu Val Lys Gly 
            180                 185                 190         


Thr Trp Glu Arg Pro Gly Gly Ala Ala Pro Leu Gly Tyr Asp Phe Trp 
        195                 200                 205             


Tyr Gln Pro Arg His Asn Val Met Ile Ser Thr Glu Trp Ala Ala Pro 
    210                 215                 220                 


Asn Val Leu Arg Asp Gly Phe Asn Pro Ala Asp Val Glu Ala Gly Leu 
225                 230                 235                 240 


Tyr Gly Ser His Leu Tyr Val Trp Asp Trp Gln Arg His Glu Ile Val 
                245                 250                 255     


Gln Thr Leu Ser Leu Lys Asp Gly Leu Ile Pro Leu Glu Ile Arg Phe 
            260                 265                 270         


Leu His Asn Pro Asp Ala Ala Gln Gly Phe Val Gly Cys Ala Leu Ser 
        275                 280                 285             


Ser Thr Ile Gln Arg Phe Tyr Lys Asn Glu Gly Gly Thr Trp Ser Val 
    290                 295                 300                 


Glu Lys Val Ile Gln Val Pro Pro Lys Lys Val Lys Gly Trp Leu Leu 
305                 310                 315                 320 


Pro Glu Met Pro Gly Leu Ile Thr Asp Ile Leu Leu Ser Leu Asp Asp 
                325                 330                 335     


Arg Phe Leu Tyr Phe Ser Asn Trp Leu His Gly Asp Leu Arg Gln Tyr 
            340                 345                 350         


Asp Ile Ser Asp Pro Gln Arg Pro Arg Leu Thr Gly Gln Leu Phe Leu 
        355                 360                 365             


Gly Gly Ser Ile Val Lys Gly Gly Pro Val Gln Val Leu Glu Asp Glu 
    370                 375                 380                 


Glu Leu Lys Ser Gln Pro Glu Pro Leu Val Val Lys Gly Lys Arg Val 
385                 390                 395                 400 


Ala Gly Gly Pro Gln Met Ile Gln Leu Ser Leu Asp Gly Lys Arg Leu 
                405                 410                 415     


Tyr Ile Thr Thr Ser Leu Tyr Ser Ala Trp Asp Lys Gln Phe Tyr Pro 
            420                 425                 430         


Asp Leu Ile Arg Glu Gly Ser Val Met Leu Gln Val Asp Val Asp Thr 
        435                 440                 445             


Val Lys Gly Gly Leu Lys Leu Asn Pro Asn Phe Leu Val Asp Phe Gly 
    450                 455                 460                 


Lys Glu Pro Leu Gly Pro Ala Leu Ala His Glu Leu Arg Tyr Pro Gly 
465                 470                 475                 480 


Gly Asp Cys Ser Ser Asp Ile Trp Ile 
                485                 


<210> 10
<211> 187
<212> PRT
<213> Homo sapiens

<400> 10
Met Pro Val Asp Leu Ser Lys Trp Ser Gly Pro Leu Ser Leu Gln Glu 
1               5                   10                  15      


Val Asp Glu Gln Pro Gln His Pro Leu His Val Thr Tyr Ala Gly Ala 
            20                  25                  30          


Ala Val Asp Glu Leu Gly Lys Val Leu Thr Pro Thr Gln Val Lys Asn 
        35                  40                  45              


Arg Pro Thr Ser Ile Ser Trp Asp Gly Leu Asp Ser Gly Lys Leu Tyr 
    50                  55                  60                  


Thr Leu Val Leu Thr Asp Pro Asp Ala Pro Ser Arg Lys Asp Pro Lys 
65                  70                  75                  80  


Tyr Arg Glu Trp His His Phe Leu Val Val Asn Met Lys Gly Asn Asp 
                85                  90                  95      


Ile Ser Ser Gly Thr Val Leu Ser Asp Tyr Val Gly Ser Gly Pro Pro 
            100                 105                 110         


Lys Gly Thr Gly Leu His Arg Tyr Val Trp Leu Val Tyr Glu Gln Asp 
        115                 120                 125             


Arg Pro Leu Lys Cys Asp Glu Pro Ile Leu Ser Asn Arg Ser Gly Asp 
    130                 135                 140                 


His Arg Gly Lys Phe Lys Val Ala Ser Phe Arg Lys Lys Tyr Glu Leu 
145                 150                 155                 160 


Arg Ala Pro Val Ala Gly Thr Cys Tyr Gln Ala Glu Trp Asp Asp Tyr 
                165                 170                 175     


Val Pro Lys Leu Tyr Glu Gln Leu Ser Gly Lys 
            180                 185         


<210> 11
<211> 319
<212> PRT
<213> Homo sapiens

<400> 11
Met Ala Ser Ser Ala Ala Gly Cys Val Val Ile Val Gly Ser Gly Val 
1               5                   10                  15      


Ile Gly Arg Ser Trp Ala Met Leu Phe Ala Ser Gly Gly Phe Gln Val 
            20                  25                  30          


Lys Leu Tyr Asp Ile Glu Gln Gln Gln Ile Arg Asn Ala Leu Glu Asn 
        35                  40                  45              


Ile Arg Lys Glu Met Lys Leu Leu Glu Gln Ala Gly Ser Leu Lys Gly 
    50                  55                  60                  


Ser Leu Ser Val Glu Glu Gln Leu Ser Leu Ile Ser Gly Cys Pro Asn 
65                  70                  75                  80  


Ile Gln Glu Ala Val Glu Gly Ala Met His Ile Gln Glu Cys Val Pro 
                85                  90                  95      


Glu Asp Leu Glu Leu Lys Lys Lys Ile Phe Ala Gln Leu Asp Ser Ile 
            100                 105                 110         


Ile Asp Asp Arg Val Ile Leu Ser Ser Ser Thr Ser Cys Leu Met Pro 
        115                 120                 125             


Ser Lys Leu Phe Ala Gly Leu Val His Val Lys Gln Cys Ile Val Ala 
    130                 135                 140                 


His Pro Val Asn Pro Pro Tyr Tyr Ile Pro Leu Val Glu Leu Val Pro 
145                 150                 155                 160 


His Pro Glu Thr Ala Pro Thr Thr Val Asp Arg Thr His Ala Leu Met 
                165                 170                 175     


Lys Lys Ile Gly Gln Cys Pro Met Arg Val Gln Lys Glu Val Ala Gly 
            180                 185                 190         


Phe Val Leu Asn Arg Leu Gln Tyr Ala Ile Ile Ser Glu Ala Trp Arg 
        195                 200                 205             


Leu Val Glu Glu Gly Ile Val Ser Pro Ser Asp Leu Asp Leu Val Met 
    210                 215                 220                 


Ser Glu Gly Leu Gly Met Arg Tyr Ala Phe Ile Gly Pro Leu Glu Thr 
225                 230                 235                 240 


Met His Leu Asn Ala Glu Gly Met Leu Ser Tyr Cys Asp Arg Tyr Ser 
                245                 250                 255     


Glu Gly Ile Lys His Val Leu Gln Thr Phe Gly Pro Ile Pro Glu Phe 
            260                 265                 270         


Ser Arg Ala Thr Ala Glu Lys Val Asn Gln Asp Met Cys Met Lys Val 
        275                 280                 285             


Pro Asp Asp Pro Glu His Leu Ala Ala Arg Arg Gln Trp Arg Asp Glu 
    290                 295                 300                 


Cys Leu Met Arg Leu Ala Lys Leu Lys Ser Gln Val Gln Pro Gln 
305                 310                 315                 


