                         SEQUENCE LISTING

<110>  The Texas A&M University System
       Scott & White Healthcare
       
 
<120>  CANCER BIOMARKERS AND THERAPEUTICS

<130>  V0223.70007WO00

<150>  61/675,375
<151>  2012-07-25

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ala Pro Gly Ser Ala Arg Arg Pro Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Met His Cys Ala Ser Ala Ala Met Phe Met 
            20                  25                  30          


Val Lys Asn Gly Asn Gly Thr Ala Cys Ile Met Ala Asn Phe Ser Ala 
        35                  40                  45              


Ala Phe Ser Val Asn Tyr Asp Thr Lys Ser Gly Pro Lys Asn Met Thr 
    50                  55                  60                  


Phe Asp Leu Pro Ser Asp Ala Thr Val Val Leu Asn Arg Ser Ser Cys 
65                  70                  75                  80  


Gly Lys Glu Asn Thr Ser Asp Pro Ser Leu Val Ile Ala Phe Gly Arg 
                85                  90                  95      


Gly His Thr Leu Thr Leu Asn Phe Thr Arg Asn Ala Thr Arg Tyr Ser 
            100                 105                 110         


Val Gln Leu Met Ser Phe Val Tyr Asn Leu Ser Asp Thr His Leu Phe 
        115                 120                 125             


Pro Asn Ala Ser Ser Lys Glu Ile Lys Thr Val Glu Ser Ile Thr Asp 
    130                 135                 140                 


Ile Arg Ala Asp Ile Asp Lys Lys Tyr Arg Cys Val Ser Gly Thr Gln 
145                 150                 155                 160 


Val His Met Asn Asn Val Thr Val Thr Leu His Asp Ala Thr Ile Gln 
                165                 170                 175     


Ala Tyr Leu Ser Asn Ser Ser Phe Ser Arg Gly Glu Thr Arg Cys Glu 
            180                 185                 190         


Gln Asp Arg Pro Ser Pro Thr Thr Ala Pro Pro Ala Pro Pro Ser Pro 
        195                 200                 205             


Ser Pro Ser Pro Val Pro Lys Ser Pro Ser Val Asp Lys Tyr Asn Val 
    210                 215                 220                 


Ser Gly Thr Asn Gly Thr Cys Leu Leu Ala Ser Met Gly Leu Gln Leu 
225                 230                 235                 240 


Asn Leu Thr Tyr Glu Arg Lys Asp Asn Thr Thr Val Thr Arg Leu Leu 
                245                 250                 255     


Asn Ile Asn Pro Asn Lys Thr Ser Ala Ser Gly Ser Cys Gly Ala His 
            260                 265                 270         


Leu Val Thr Leu Glu Leu His Ser Glu Gly Thr Thr Val Leu Leu Phe 
        275                 280                 285             


Gln Phe Gly Met Asn Ala Ser Ser Ser Arg Phe Phe Leu Gln Gly Ile 
    290                 295                 300                 


Gln Leu Asn Thr Ile Leu Pro Asp Ala Arg Asp Pro Ala Phe Lys Ala 
305                 310                 315                 320 


Ala Asn Gly Ser Leu Arg Ala Leu Gln Ala Thr Val Gly Asn Ser Tyr 
                325                 330                 335     


Lys Cys Asn Ala Glu Glu His Val Arg Val Thr Lys Ala Phe Ser Val 
            340                 345                 350         


Asn Ile Phe Lys Val Trp Val Gln Ala Phe Lys Val Glu Gly Gly Gln 
        355                 360                 365             


Phe Gly Ser Val Glu Glu Cys Leu Leu Asp Glu Asn Ser Met Leu Ile 
    370                 375                 380                 


Pro Ile Ala Val Gly Gly Ala Leu Ala Gly Leu Val Leu Ile Val Leu 
385                 390                 395                 400 


Ile Ala Tyr Leu Val Gly Arg Lys Arg Ser His Ala Gly Tyr Gln Thr 
                405                 410                 415     


Ile 
    


<210>  2
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val 
    50                  55                  60                  


Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly 
65                  70                  75                  80  


Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe 
                85                  90                  95      


Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp 
            100                 105                 110         


Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp 
        115                 120                 125             


Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg 
    130                 135                 140                 


Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu 
145                 150                 155                 160 


Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp 
            180                 185                 190         


Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro 
        195                 200                 205             


Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser 
    210                 215                 220                 


Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln 
225                 230                 235                 240 


Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro 
                245                 250                 255     


Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu 
            260                 265                 270         


Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val 
        275                 280                 285             


Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr 
    290                 295                 300                 


Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr 
305                 310                 315                 320 


Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr 
                325                 330                 335     


Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val 
            340                 345                 350         


Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Asp Cys 
        355                 360                 365             


Ser Ala Asp Asp Asp Asn Phe Leu Val Pro Ile Ala Val Gly Ala Ala 
    370                 375                 380                 


Leu Ala Gly Val Leu Ile Leu Val Leu Leu Ala Tyr Phe Ile Gly Leu 
385                 390                 395                 400 


Lys His His His Ala Gly Tyr Glu Gln Phe 
                405                 410 


<210>  3
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Pro Arg Gln Leu Ser Ala Ala Ala Ala Leu Phe Ala Ser Leu Ala 
1               5                   10                  15      


Val Ile Leu His Asp Gly Ser Gln Met Arg Ala Lys Ala Phe Pro Glu 
            20                  25                  30          


Thr Arg Asp Tyr Ser Gln Pro Thr Ala Ala Ala Thr Val Gln Asp Ile 
        35                  40                  45              


Lys Lys Pro Val Gln Gln Pro Ala Lys Gln Ala Pro His Gln Thr Leu 
    50                  55                  60                  


Ala Ala Arg Phe Met Asp Gly His Ile Thr Phe Gln Thr Ala Ala Thr 
65                  70                  75                  80  


Val Lys Ile Pro Thr Thr Thr Pro Ala Thr Thr Lys Asn Thr Ala Thr 
                85                  90                  95      


Thr Ser Pro Ile Thr Tyr Thr Leu Val Thr Thr Gln Ala Thr Pro Asn 
            100                 105                 110         


Asn Ser His Thr Ala Pro Pro Val Thr Glu Val Thr Val Gly Pro Ser 
        115                 120                 125             


Leu Ala Pro Tyr Ser Leu Pro Pro Thr Ile Thr Pro Pro Ala His Thr 
    130                 135                 140                 


Thr Gly Thr Ser Ser Ser Thr Val Ser His Thr Thr Gly Asn Thr Thr 
145                 150                 155                 160 


Gln Pro Ser Asn Gln Thr Thr Leu Pro Ala Thr Leu Ser Ile Ala Leu 
                165                 170                 175     


His Lys Ser Thr Thr Gly Gln Lys Pro Val Gln Pro Thr His Ala Pro 
            180                 185                 190         


Gly Thr Thr Ala Ala Ala His Asn Thr Thr Arg Thr Ala Ala Pro Ala 
        195                 200                 205             


Ser Thr Val Pro Gly Pro Thr Leu Ala Pro Gln Pro Ser Ser Val Lys 
    210                 215                 220                 


Thr Gly Ile Tyr Gln Val Leu Asn Gly Ser Arg Leu Cys Ile Lys Ala 
225                 230                 235                 240 


Glu Met Gly Ile Gln Leu Ile Val Gln Asp Lys Glu Ser Val Phe Ser 
                245                 250                 255     


Pro Arg Arg Tyr Phe Asn Ile Asp Pro Asn Ala Thr Gln Ala Ser Gly 
            260                 265                 270         


Asn Cys Gly Thr Arg Lys Ser Asn Leu Leu Leu Asn Phe Gln Gly Gly 
        275                 280                 285             


Phe Val Asn Leu Thr Phe Thr Lys Asp Glu Glu Ser Tyr Tyr Ile Ser 
    290                 295                 300                 


Glu Val Gly Ala Tyr Leu Thr Val Ser Asp Pro Glu Thr Ile Tyr Gln 
305                 310                 315                 320 


Gly Ile Lys His Ala Val Val Met Phe Gln Thr Ala Val Gly His Ser 
                325                 330                 335     


Phe Lys Cys Val Ser Glu Gln Ser Leu Gln Leu Ser Ala His Leu Gln 
            340                 345                 350         


Val Lys Thr Thr Asp Val Gln Leu Gln Ala Phe Asp Phe Glu Asp Asp 
        355                 360                 365             


His Phe Gly Asn Val Asp Glu Cys Ser Ser Asp Tyr Thr Ile Val Leu 
    370                 375                 380                 


Pro Val Ile Gly Ala Ile Val Val Gly Leu Cys Leu Met Gly Met Gly 
385                 390                 395                 400 


Val Tyr Lys Ile Arg Leu Arg Cys Gln Ser Ser Gly Tyr Gln Arg Ile 
                405                 410                 415     


<210>  4
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Ser Glu Lys Thr Phe Lys Gln Arg Arg Thr Phe Glu Gln Arg 
1               5                   10                  15      


Val Glu Asp Val Arg Leu Ile Arg Glu Gln His Pro Thr Lys Ile Pro 
            20                  25                  30          


Val Ile Ile Glu Arg Tyr Lys Gly Glu Lys Gln Leu Pro Val Leu Asp 
        35                  40                  45              


Lys Thr Lys Phe Leu Val Pro Asp His Val Asn Met Ser Glu Leu Ile 
    50                  55                  60                  


Lys Ile Ile Arg Arg Arg Leu Gln Leu Asn Ala Asn Gln Ala Phe Phe 
65                  70                  75                  80  


Leu Leu Val Asn Gly His Ser Met Val Ser Val Ser Thr Pro Ile Ser 
                85                  90                  95      


Glu Val Tyr Glu Ser Glu Lys Asp Glu Asp Gly Phe Leu Tyr Met Val 
            100                 105                 110         


Tyr Ala Ser Gln Glu Thr Phe Gly Met Lys Leu Ser Val 
        115                 120                 125 


<210>  5
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Pro Ser Asp Arg Pro Phe Lys Gln Arg Arg Ser Phe Ala Asp Arg 
1               5                   10                  15      


Cys Lys Glu Val Gln Gln Ile Arg Asp Gln His Pro Ser Lys Ile Pro 
            20                  25                  30          


Val Ile Ile Glu Arg Tyr Lys Gly Glu Lys Gln Leu Pro Val Leu Asp 
        35                  40                  45              


Lys Thr Lys Phe Leu Val Pro Asp His Val Asn Met Ser Glu Leu Val 
    50                  55                  60                  


Lys Ile Ile Arg Arg Arg Leu Gln Leu Asn Pro Thr Gln Ala Phe Phe 
65                  70                  75                  80  


Leu Leu Val Asn Gln His Ser Met Val Ser Val Ser Thr Pro Ile Ala 
                85                  90                  95      


Asp Ile Tyr Glu Gln Glu Lys Asp Glu Asp Gly Phe Leu Tyr Met Val 
            100                 105                 110         


Tyr Ala Ser Gln Glu Thr Phe Gly Phe 
        115                 120     


<210>  6
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Pro Pro Gln Lys Ile Pro Ser Val Arg Pro Phe Lys Gln Arg 
1               5                   10                  15      


Lys Ser Leu Ala Ile Arg Gln Glu Glu Val Ala Gly Ile Arg Ala Lys 
            20                  25                  30          


Phe Pro Asn Lys Ile Pro Val Val Val Glu Arg Tyr Pro Arg Glu Thr 
        35                  40                  45              


Phe Leu Pro Pro Leu Asp Lys Thr Lys Phe Leu Val Pro Gln Glu Leu 
    50                  55                  60                  


Thr Met Thr Gln Phe Leu Ser Ile Ile Arg Ser Arg Met Val Leu Arg 
65                  70                  75                  80  


Ala Thr Glu Ala Phe Tyr Leu Leu Val Asn Asn Lys Ser Leu Val Ser 
                85                  90                  95      


Met Ser Ala Thr Met Ala Glu Ile Tyr Arg Asp Tyr Lys Asp Glu Asp 
            100                 105                 110         


Gly Phe Val Tyr Met Thr Tyr Ala Ser Gln Glu Thr Phe Gly Cys Leu 
        115                 120                 125             


Glu Ser Ala Ala Pro Arg Asp Gly Ser Ser Leu Glu Asp Arg Pro Cys 
    130                 135                 140                 


Asn Pro Leu 
145         


<210>  7
<211>  2560
<212>  DNA
<213>  Homo sapiens

<400>  7
tgcggggagc cgagccgccg gcgctcgacg cgcgcgctct cgcgagaccc gcgggatcac       60

gtgacgcccg ggcgcggcgc agctcacgtg acaagcgctg ccggccgcgg tgtcttcttc      120

gtgccggcgt cgcagtggcc gggcctcttg cgtctggtaa cgccgctgtc tctaacgcca      180

gcccttggcg cccgcgcccc gccaccgcag cgcccggcag tccgcggccc aaccgccgcc      240

cgcgcccccg ctccccgcac cgtacccggc cgcctcgcgc catggcggcc cccggcagcg      300

cccggcgacc cctgctgctg ctactgctgt tgctgctgct cggcctcatg cattgtgcgt      360

cagcagcaat gtttatggtg aaaaatggca acgggaccgc gtgcataatg gccaacttct      420

ctgctgcctt ctcagtgaac tacgacacca agagtggccc taagaacatg acctttgacc      480

tgccatcaga tgccacagtg gtgctcaacc gcagctcctg tggaaaagag aacacttctg      540

accccagtct cgtgattgct tttggaagag gacatacact cactctcaat ttcacgagaa      600

atgcaacacg ttacagcgtc cagctcatga gttttgttta taacttgtca gacacacacc      660

ttttccccaa tgcgagctcc aaagaaatca agactgtgga atctataact gacatcaggg      720

cagatataga taaaaaatac agatgtgtta gtggcaccca ggtccacatg aacaacgtga      780

ccgtaacgct ccatgatgcc accatccagg cgtacctttc caacagcagc ttcagcaggg      840

gagagacacg ctgtgaacaa gacaggcctt ccccaaccac agcgccccct gcgccaccca      900

gcccctcgcc ctcacccgtg cccaagagcc cctctgtgga caagtacaac gtgagcggca      960

ccaacgggac ctgcctgctg gccagcatgg ggctgcagct gaacctcacc tatgagagga     1020

aggacaacac gacggtgaca aggcttctca acatcaaccc caacaagacc tcggccagcg     1080

ggagctgcgg cgcccacctg gtgactctgg agctgcacag cgagggcacc accgtcctgc     1140

tcttccagtt cgggatgaat gcaagttcta gccggttttt cctacaagga atccagttga     1200

atacaattct tcctgacgcc agagaccctg cctttaaagc tgccaacggc tccctgcgag     1260

cgctgcaggc cacagtcggc aattcctaca agtgcaacgc ggaggagcac gtccgtgtca     1320

cgaaggcgtt ttcagtcaat atattcaaag tgtgggtcca ggctttcaag gtggaaggtg     1380

gccagtttgg ctctgtggag gagtgtctgc tggacgagaa cagcatgctg atccccatcg     1440

ctgtgggtgg tgccctggcg gggctggtcc tcatcgtcct catcgcctac ctcgtcggca     1500

ggaagaggag tcacgcaggc taccagacta tctagcctgg tgcacgcagg cacagcagct     1560

gcaggggcct ctgttccttt ctctgggctt agggtcctgt cgaaggggag gcacactttc     1620

tggcaaacgt ttctcaaatc tgcttcatcc aatgtgaagt tcatcttgca gcatttacta     1680

tgcacaacag agtaactatc gaaatgacgg tgttaatttt gctaactggg ttaaatattt     1740

tgctaactgg ttaaacatta atatttacca aagtaggatt ttgagggtgg gggtgctctc     1800

tctgaggggg tgggggtgcc gctgtctctg aggggtgggg gtgccgctgt ctctgagggg     1860

tgggggtgcc gctctctctg agggggtggg ggtgccgctt tctctgaggg ggtgggggtg     1920

ccgctctctc tgagggggtg ggggtgctgc tctctccgag gggtggaatg ccgctgtctc     1980

tgaggggtgg gggtgccgct ctaaattggc tccatatcat ttgagtttag ggttctggtg     2040

tttggtttct tcattcttta ctgcactcag atttaagcct tacaaaggga aagcctctgg     2100

ccgtcacacg taggacgcat gaaggtcact cgtggtgagg ctgacatgct cacacattac     2160

aacagtagag agggaaaatc ctaagacaga ggaactccag agatgagtgt ctggagcgct     2220

tcagttcagc tttaaaggcc aggacgggcc acacgtggct ggcggcctcg ttccagtggc     2280

ggcacgtcct tgggcgtctc taatgtctgc agctcaaggg ctggcacttt tttaaatata     2340

aaaatgggtg ttatttttat ttttttttgt aaagtgattt ttggtcttct gttgacattc     2400

ggggtgatcc tgttctgcgc tgtgtacaat gtgagatcgg tgcgttctcc tgatgttttg     2460

ccgtggcttg gggattgtac acgggaccag ctcacgtaat gcattgcctg taacaatgta     2520

ataaaaagcc tctttctttt aaaaaaaaaa aaaaaaaaaa                           2560


<210>  8
<211>  6603
<212>  DNA
<213>  Homo sapiens

<400>  8
aagaaagagc cccgccccta gtcttatgac tcgcactgaa gcgccgattc ctggcttttg       60

caaggctgtg gtcggtggtc atcagtgctc ttgacccagg tccagcgagc cttttccctg      120

gtgttgcagc tgttgttgta ccgccgccgt cgccgccgtc gccgcctgct ctgcggggtc      180

atggtgtgct tccgcctctt cccggttccg ggctcagggc tcgttctggt ctgcctagtc      240

ctgggagctg tgcggtctta tgcattggaa cttaatttga cagattcaga aaatgccact      300

tgcctttatg caaaatggca gatgaatttc acagtacgct atgaaactac aaataaaact      360

tataaaactg taaccatttc agaccatggc actgtgacat ataatggaag catttgtggg      420

gatgatcaga atggtcccaa aatagcagtg cagttcggac ctggcttttc ctggattgcg      480

aattttacca aggcagcatc tacttattca attgacagcg tctcattttc ctacaacact      540

ggtgataaca caacatttcc tgatgctgaa gataaaggaa ttcttactgt tgatgaactt      600

ttggccatca gaattccatt gaatgacctt tttagatgca atagtttatc aactttggaa      660

aagaatgatg ttgtccaaca ctactgggat gttcttgtac aagcttttgt ccaaaatggc      720

acagtgagca caaatgagtt cctgtgtgat aaagacaaaa cttcaacagt ggcacccacc      780

atacacacca ctgtgccatc tcctactaca acacctactc caaaggaaaa accagaagct      840

ggaacctatt cagttaataa tggcaatgat acttgtctgc tggctaccat ggggctgcag      900

ctgaacatca ctcaggataa ggttgcttca gttattaaca tcaaccccaa tacaactcac      960

tccacaggca gctgccgttc tcacactgct ctacttagac tcaatagcag caccattaag     1020

tatctagact ttgtctttgc tgtgaaaaat gaaaaccgat tttatctgaa ggaagtgaac     1080

atcagcatgt atttggttaa tggctccgtt ttcagcattg caaataacaa tctcagctac     1140

tgggatgccc ccctgggaag ttcttatatg tgcaacaaag agcagactgt ttcagtgtct     1200

ggagcatttc agataaatac ctttgatcta agggttcagc ctttcaatgt gacacaagga     1260

aagtattcta cagctcaaga ctgcagtgca gatgacgaca acttccttgt gcccatagcg     1320

gtgggagctg ccttggcagg agtacttatt ctagtgttgc tggcttattt tattggtctc     1380

aagcaccatc atgctggata tgagcaattt tagaatctgc aacctgattg attatataaa     1440

aatacatgca aataacaaga ttttcttacc tctcagttgt tgaaacactt tgcttcttaa     1500

aattgatatg ttgaaacttt aattctttta tcaatcccag cattttgaga tcagtcttta     1560

ttaataaaac ctgttctctt taatcagctt aaaatccaaa gtgtcatatt tactggtcct     1620

ggagacaaac ttgttcaaaa gaacatcaac gtgcaatgtt ttaaggtcta tcttaagaag     1680

ccctggccaa attttgatcc taaccttgaa gtatgccttg aacttattaa catggccatt     1740

ataagaataa aatatgtagt tgtgtcttaa tggaattaat aaatgtcatt tcactactgg     1800

tgttctgttt caatgtataa ggactatagt gatttaaact catcaatgtg cctttgcata     1860

aagttcatta aataaatatt gatgtggtat aaatgcccat cagatatgct taaacttggt     1920

tttcagttga atgaagtaga gaatgtcctc aggaccatca gcattttaaa ggttatgtga     1980

cttttgctga tttctctgag ttcaagttaa gcatgaagtt agtacctcaa gcctgtgatt     2040

tttccctagg gatgatacag acccaagagg ctacaacaga acttaaactg gcttcgtaat     2100

tagagttttt aagataattg tttgtttttc agcaatatag actgaaaaga tccaagcata     2160

tttagccact tgcttttttg tttcttgttt tgttcttctt tggatgcctg attagtattg     2220

aaagatagaa atattctatg aactaattag gacagattgt gttgtgtttc tctacctcat     2280

cttgttgatc tctggagcat taaaatctat ttagtgttgt catcagtgtg gtacttatga     2340

aatgtaagct aacagcaatc tcagaaggga ggcagtgaag catagcaact aggctcttgt     2400

ttcttcaaga tggcccctgt ggggcagtgc atagatgggg gtgtaaagag aagctgttgg     2460

cattaaaatg agctagataa tcagcccttg ttgaagcata ttccatggta taagagtagc     2520

acagacatga aacatagata aagaaggaag gcttaataga ctagaagact tccacattga     2580

agtattatta acccattgta tgtatatagg ggcatgatca gagtctctat aacttcctga     2640

ttaacaatac agtgtatctt gttacccagc tgtcagtctt tgagagcttt cagtaaaata     2700

tagtaaattc tttcagcata ggctaatgtg tggttactga gatgagtgtt gtgtactcag     2760

aaccgtagca acatttttat gaatggtaaa agtacaagag gaggaaaagt taaaattaga     2820

agaaaagtac aagttattgc ttaatcataa atcacaccag ataacacatt ttgttaattt     2880

cattagctat tactggaaag gaccttaacg attatttaca gaaaggggag tgaaattcat     2940

tgaggttcca tatcaagtgg gcaacaaaac tattactagc attttgataa aaattgcccc     3000

taatgaaatc tagtcactca acagtaaaac aacagctggt ttacacttga aattatgaga     3060

tcagaattgg gcactttggg cttccgtact atgttttgct taagtttttt ttttaatact     3120

aatatgggct ttttcagtag taatatacca aaacacttct attttaatct ctgtttgcta     3180

cttcaaaacc taatcctcct cagatgggat catgagcata agaggaaaag agaagagaat     3240

gaatacttgt tgacctcttg atgtgtatca gatgctttag aaatgtaatt gtatttaatc     3300

ctcaaatacc ttataggtat tattatcccc ttcttacaga tgaggaaagt gaggcccagt     3360

ttaaataact tgcccaaggt cctttggcta gtactggaag gagtcaagat ttaaacacag     3420

ttctgtctga atccagaact caaaatctac attgcacatg ttgctttcct ggtggttcgg     3480

tggaatggac tgcaacgcat tagatactgc tgttattctt ccaggccacc gctcagctaa     3540

aaataattgt gtgtgtgtgt atatatatat atatgtacac acacacacat atatatacac     3600

acacacatat atatacacat atacatatat atacacatat atatacacac acatatatat     3660

gtatatatat actacattct tgatcctaag tcttttttaa cttaaatttt attacttata     3720

cagaattctt atttatactt taattatagg tgtgacgaag agaaagagag tagggaaata     3780

cacaggcagt ggttttaagt gtagatgatg gctccttaac ccagtgtcat tagataatca     3840

aacctaaagt cttcccatat taggcaagcg caattctcta ttttggaccc ttcccattct     3900

tcccttacct tctgcttttc gtactgagga atttcgtgtg attttagata aagtgataat     3960

gagatattga gcaaataaga aaatagaggt aatgctataa aaaactaagc tatgtacact     4020

ttcaaaatgc atgtttcttg catgcttttt actacttaat tgcattcttt gctaatttcc     4080

tttccttgct gtctgttctt ttctaacagc tgaagaatgt tctgctgact ctgacctcaa     4140

ctttcttatt cctgttgcag tgggtgtggc cttgggcttc cttataattg ttgtctttat     4200

ctcttatatg attggaagaa ggaaaagtcg tactggttat cagtctgtgt aatcagttaa     4260

atctagtgtt tgtttgtttt tttcaattag aagttacgtt tccattggct aaaagccagg     4320

acatgctgtg caatagattg tttaagatat gcagactaac ttcagtgagt tcctagctaa     4380

cttgggcatg agtacactta tttaagacaa aatatattag gaccaatttt tttctgtttt     4440

ttttcttcct ttgttaaagt ataattaaaa gaaaaattgt ggcttagaat tttttaagta     4500

aataatgatt ttaagcccct ggatccaatt atgaaagcat ttttgctgat gtgtaatttt     4560

atatgttaca gttacttata ttttactact ttgatgttat ttgcaaaatc aaaggtgtta     4620

aagaatttaa cttgcttcag gaaataaatt caagaacata gtggattcat tttcattggt     4680

ggcagacacg aaatttggtt catgataaga cttcctttcc ccacctcctg atcagcatta     4740

tttaaatctg tatttttctg ttagttaaga aagaaatggc ttcatgatat tgtatttaat     4800

agcaaaagtt tggctgtctt cttcattact gttaatagct actatatttt aacaaggaga     4860

tttctttttt tgttgttgtt gttctagagt ttggaatata ctgattatct cagacttgac     4920

atttatactg aaggatgaag taagacctcc agcttttttt aaaaaaggtg ttgatttgga     4980

acacctgtat gggttatggt ttattaaggt tatggtttag aaagtttttt tccctcagag     5040

ccttaacttg ttaagaaggt tcatttatcc tgcactgaaa acaaaaactc tatatacttt     5100

gtttgtgtgc ctcctgcact ctcccattcc ctatgtgaat atgctctagt tgatattttt     5160

aatatattga tttctttttt ctcacagcaa caagtgctta ctctagaggt tagtgggccc     5220

tgatatgtca tcagtcagat gcctgcctag ccaaagctgg actaagatta ttctgtacat     5280

ttgttgatct tgatatagac ttatatccct gtagggactg ctaatggctc cggcttctgg     5340

agtaaggtac tggagaccac tcatccctgt gtctgcttga ttggttcagc tgttgaattg     5400

cccttttatt tggaagcagt gttgaagttg tctagggttc aaatggctgc tttgtacacc     5460

tgtcattagt ataaggcaga tgtttatttt atcaagctat tttatctcta catttaacta     5520

aaaacaaaag ttcccaaaga tctgccttca cttcagaaat tttttttgga ttaaaaaaat     5580

taagcctgaa ccttaaataa agtgagttgg ttattcattc caaggattaa gtcccaatct     5640

acctctcagc acaatgcaga agctcaccac tgtattgctg ccattaactc atgccagaac     5700

cctttgccaa taactggaat tacaaatttt tgttaaagaa aatttatcaa gatctttctt     5760

tactgccttc tctatatgta catctcaaaa acatgtacat ctcaaaaact ggagtagaaa     5820

gttagattgc tcaactacaa ctcctctaga actctatagc tctgacatac agattcacac     5880

tctcctctat ttgctaagta tgtaaagaat gttttctttt aaaatgttct cttttgagaa     5940

caactgctta tttgttataa aagcatttgg ttaaaatgat gtcatcataa aaaacagtgg     6000

ctttgtttca atacatattt ttgagatgat tatctagaag ccagattaat aaaatcagct     6060

tgtgaccttg ctaagcatat aaactggaaa ttcagataca ttcaaaatta tgggttcatt     6120

taaaagtgtt ctaccttttg ggtatgagac taatatcact aattcctcaa tagttatcat     6180

ggctctatct taattaatta gaaaatatgt gtgtttaatt ctttgagaat taaaatagag     6240

aatattaaca gagggttaaa aactgcttca actccaataa gataaaggaa gctcaaaatc     6300

tatgagctga gtgttcaatt agctttgcct actgagttca attttatgtc aatacaacag     6360

tggatcagac agtacgactt tgaactggtg aatgtaaaca attgtttttc acctaagctg     6420

ctttggaaga actgatgctt gctgctaact aaagttttgg atgtatcgat ttagagaacc     6480

aattaatacc tgcaaaataa agcatactgt ggtacttctg tttgatctag tatgtgtgat     6540

tttagattga tggattaaaa attaataaag atcatacatt ccataccaaa aaaaaaaaaa     6600

aaa                                                                   6603


<210>  9
<211>  3341
<212>  DNA
<213>  Homo sapiens

<400>  9
ccgggccccg gcggctgcgc cgagtccccg cccctccctg ctccgtaggg gtaggagggg       60

gccggcggag tttccctccc cgcccagcgg ccctgggcgg gcttttcggc tgcttctcat      120

aagcaggtgg tttcgtttct ccggcacagg taggtttctc tggcaccgat tcggggcctg      180

cccggacttc gccgcacgct gcagaacctc gcccagcgcc caccatgccc cggcagctca      240

gcgcggcggc cgcgctcttc gcgtccctgg ccgtaatttt gcacgatggc agtcaaatga      300

gagcaaaagc atttccagaa accagagatt attctcaacc tactgcagca gcaacagtac      360

aggacataaa aaaacctgtc cagcaaccag ctaagcaagc acctcaccaa actttagcag      420

caagattcat ggatggtcat atcacctttc aaacagcggc cacagtaaaa attccaacaa      480

ctaccccagc gactacaaaa aacactgcaa ccaccagccc aattacctac accctggtca      540

caacccaggc cacacccaac aactcacaca cagctcctcc agttactgaa gttacagtcg      600

gccctagctt agccccttat tcactgccac ccaccatcac cccaccagct catacaactg      660

gaaccagttc atcaaccgtc agccacacaa ctgggaacac cactcaaccc agtaaccaga      720

ccacccttcc agcaacttta tcgatagcac tgcacaaaag cacaaccggt cagaagcctg      780

ttcaacccac ccatgcccca ggaacaacgg cagctgccca caataccacc cgcacagctg      840

cacctgcctc cacggttcct gggcccaccc ttgcacctca gccatcgtca gtcaagactg      900

gaatttatca ggttctaaac ggaagcagac tctgtataaa agcagagatg gggatacagc      960

tgattgttca agacaaggag tcggtttttt cacctcggag atacttcaac atcgacccca     1020

acgcaacgca agcctctggg aactgtggca cccgaaaatc caaccttctg ttgaattttc     1080

agggcggatt tgtgaatctc acatttacca aggatgaaga atcatattat atcagtgaag     1140

tgggagccta tttgaccgtc tcagatccag agacaattta ccaaggaatc aaacatgcgg     1200

tggtgatgtt ccagacagca gtcgggcatt ccttcaagtg cgtgagtgaa cagagcctcc     1260

agttgtcagc ccacctgcag gtgaaaacaa ccgatgtcca acttcaagcc tttgattttg     1320

aagatgacca ctttggaaat gtggatgagt gctcgtctga ctacacaatt gtgcttcctg     1380

tgattggggc catcgtggtt ggtctctgcc ttatgggtat gggtgtctat aaaatccgcc     1440

taaggtgtca atcatctgga taccagagaa tctaattgtt gcccgggggg aatgaaaata     1500

atggaattta gagaactctt tcatcccttc caggatggat gttgggaaat tccctcagag     1560

tgtgggtcct tcaaacaatg taaaccacca tcttctattc aaatgaagtg agtcatgtgt     1620

gatttaagtt caggcagcac atcaatttct aaatactttt tgtttatttt atgaaagata     1680

tagtgagctg tttattttct agtttccttt agaatatttt agccactcaa agtcaacatt     1740

tgagatatgt tgaattaaca taatatatgt aaagtagaat aagccttcaa attataaacc     1800

aagggtcaat tgtaactaat actactgtgt gtgcattgaa gattttattt tacccttgat     1860

cttaacaaag cctttgcttt gttatcaaat ggactttcag tgcttttact atctgtgttt     1920

tatggtttca tgtaacatac atattcctgg tgtagcactt aactcctttt ccactttaaa     1980

tttgtttttg ttttttgaga cggagtttca ctcttgtcac ccaggctgga gtacagtggc     2040

acgatctcgg cttatggcaa cctccgcctc ccgggttcaa gtgattctcc tgcttcagct     2100

tcccgagtag ctgggattac aggcacacac taccacgcct ggctaatttt tgtattttta     2160

ttatagacgg ggtttcacca tgttggccag actggtcttg aactcttgac ctcaggtgat     2220

ccacccacct cagcctccca aagtgctggg attacaggca tgagccattg cgcccggcct     2280

taaatgtttt ttttaatcat caaaaagaac aacatatctc aggttgtcta agtgttttta     2340

tgtaaaacca acaaaaagaa caaatcagct tatatttttt atcttgatga ctcctgctcc     2400

agaatcgcta gactaagaat taggtggcta cagatggtag aactaaacaa taagcaagag     2460

acaataataa tggcccttaa ttattaacaa agtgccagag tctaggctaa gcactttatc     2520

tatatctcat ttcattctca caacttatag gtgaatgagt aaactgagac ttaagggaac     2580

tgaatcactt aaatgtcacc tggctaactg atggcagagc cagagcttga attcatgttg     2640

gtctgacatc aaggtctttg gtcttctccc tacaccaagt tacctacaag aacaatgaca     2700

ccacactctg cctgaaggct cacacctcat accagcatac gctcacctta cagggaaatg     2760

ggtttatcca ggatcatgag acattagggt agatgaaagg agagctttgc agataacaaa     2820

atagcctatc cttaataaat cctccactct ctggaaggag actgaggggc tttgtaaaac     2880

attagtcagt tgctcatttt tatgggattg cttagctggg ctgtaaagat gaaggcatca     2940

aataaactca aagtattttt aaattttttt gataatagag aaacttcgct aaccaactgt     3000

tctttcttga gtgtatagcc ccatcttgtg gtaacttgct gcttctgcac ttcatatcca     3060

tatttcctat tgttcacttt attctgtaga gcagcctgcc aagaatttta tttctgctgt     3120

tttttttgct gctaaagaaa ggaactaagt caggatgtta acagaaaagt ccacataacc     3180

ctagaattct tagtcaagga ataattcaag tcagcctaga gaccatgttg actttcctca     3240

tgtgtttcct tatgactcag taagttggca aggtcctgac tttagtctta ataaaacatt     3300

gaattgtagt aaaggttttt gtaataaaaa cttactttgg a                         3341


<210>  10
<211>  2304
<212>  DNA
<213>  Homo sapiens

<400>  10
acgctgcgtg ccgctgctgg gttccgccac gcccgtcatg gcggcggccc cggccggctc       60

tggccccgcc cctcggtgac gcgtcgcgag tcacctgacc aggctgcggg ctgaggagat      120

acaagggaag tggctatcgc cagagtcgga ttcgccgccg cagcagccgc cgcccccggg      180

agccgccggg accctcgcgt cgtcgccgcc gccgccgccc agatccctgc accatgccgt      240

cggagaagac cttcaagcag cgccgcacct tcgaacaaag agtagaagat gtccgactta      300

ttcgagagca gcatccaacc aaaatcccgg tgataataga acgatacaag ggtgagaagc      360

agcttcctgt tctggataaa acaaagttcc ttgtacctga ccatgtcaac atgagtgagc      420

tcatcaagat aattagaagg cgcttacagc tcaatgctaa tcaggccttc ttcctgttgg      480

tgaacggaca cagcatggtc agcgtctcca caccaatctc agaggtgtat gagagtgaga      540

aagatgaaga tggattcctg tacatggtct atgcctccca ggagacgttc gggatgaaat      600

tgtcagtgta aaaccagaaa aaatgcagct cttctagaat tgtttaaacc cttaccaagg      660

aaaaaaaagg gatgttacca actgagatcg atcagttcat ccaatcacag atcatgaaac      720

agtagtgttc ccacctagga gtgttaggaa gttgtgtttg tgtttcaagc agaaaaactg      780

agctccaagt gagcacattc agctttggaa actatattat ttaatgtagg ctagcttgtt      840

ttcaaatttt aaaagtttaa aaataaaata ctttgcattc taagttgcca ataaaataga      900

ccttcaagtt attttaatgc tcttttctca ctaataggaa cttgtaattc cagcagtaat      960

ttaaaggctt tcagagagac cctgagtctt ctcttcaggt tcacagaacc cgccgccttt     1020

ttgggtagaa gttttctact cagctagaga gatctcccta agaggatctt taggcctgag     1080

ttgtgaagcg caacccccgc aaaacgcatt tgccatcaca gttggcacaa acgcagggta     1140

aacgggctgt gtgagaaaac ggccctgact gtaaactgct gaaggtccct gactcctaag     1200

agaaccacac ccaaagtcct cactcttgca ggggtagaca tttctggttt ggtttgttct     1260

ctagatagtt acacacataa agacaccact caaaaggaaa cttgaataat ttataatttt     1320

gatcgagttt cttaaaagac cctggagaaa gagtggcatt tcttctgttt caggttttgt     1380

ctgagttcaa actagtgcct gtgttgttac ggaaagcagc agtgtaccag tgtcactctg     1440

gagtacagcg ggagaaacac aaaatagtat aactgaaaac attaacattc agacacactc     1500

ccttctgcct tccggcttaa agctgtggat gatccacgtt tttgtttttt taatgttaaa     1560

tgtgtaactc agtattactg aaaaggtacc cacattttga atagtagtta tcactcttag     1620

gtcagacagc catcagaatt ctcccacacc aagtgcatgt cagttgtgga gaaaacatag     1680

caaaaagagc cgtacgctct ttacagatac taatgtcaag agttaaacct cctcaggttc     1740

aacctgtgat aaaagactag tgcttcccag tacttgcatg gggttcacta tttatagttt     1800

tcttgggagt atcacaggaa aatcacaatt acaccacttt agaccctatg tgtagcaggt     1860

cacaacttac ccttgtgtgt ttagatgtgt atgaaatacc tgtatacgtt agtgaaagct     1920

gtttactgta acggggaaaa ccagattctt tgcatctggg ccctctactg attgttaaag     1980

gagttcctgt cacctgctcc ccccaccccc gcatgcgtct gtccacttgg ctaactttta     2040

atatgtgtat ttttacatta tgtatattct taactggact gtctcgttta gactgtatac     2100

atcatatctg acattattgt aactaccgtg tgatcagtaa gattcctgta agaaatactg     2160

ctttttaaga aaaaaaataa catgctgagg ggtgacctat atcccatgtg agtggtcact     2220

ttatttatag gatctttaaa acatttttaa tgaactaagt tgaataaagg cacaattaaa     2280

aactgtcaaa aaaaaaaaaa aaaa                                            2304


<210>  11
<211>  1030
<212>  DNA
<213>  Homo sapiens

<400>  11
accgggcgag ttacctcccg cagccgcagc cgccgtgctc agcgcgagcc ccggagccct       60

tgagcgcgag gcgcggagcc cccggagccc ccaaaccgca gacacatccc cgcgccccag      120

agccccggcc tgcgcgccca gccgggcccg cgcgatgccc tcagaccggc ctttcaagca      180

gcggcggagc ttcgccgacc gctgtaagga ggtacagcag atccgcgacc agcaccccag      240

caaaatcccg gtgatcatcg agcgctacaa gggtgagaag cagctgcccg tcctggacaa      300

gaccaagttt ttggtcccgg accatgtcaa catgagcgag ttggtcaaga tcatccggcg      360

ccgcctgcag ctgaacccca cgcaggcctt cttcctgctg gtgaaccagc acagcatggt      420

gagtgtgtcc acgcccatcg cggacatcta cgagcaggag aaagacgagg acggcttcct      480

ctatatggtc tacgcctccc aggaaacctt cggcttctga gccagcagta ggggggctcg      540

gcctgggagt cggggggccc cggtcaggcc ctgcccagag agctcctggt tcctgaactg      600

agctgcctct accgtggtgg gctgggcagg catgtgcccc cctagtcaga gggcaccaac      660

ccacctactc tgcccctggg tggatcctgg gccggtcgtg ttagggttgt ccctctgggt      720

gctggctggt gggatggggg agggtgggga gcagctccca gcacccctgc tgtgtggttc      780

atcttttttt taggcccctg cctgtctgcc catctgcccc tcacccaccc gaggctctgc      840

ccaccgcctg gacctgccca cccctgaaag actggcccct ggctccccgc ccctcggtct      900

ccacgtggtg tatggatctg tggtcattgt ccctctgcag aataaagatt gctcaggcct      960

gcctggcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

aaaaaaaaaa                                                            1030


<210>  12
<211>  1192
<212>  DNA
<213>  Homo sapiens

<400>  12
ggaggaatga gttaggttcc cggttgcggg acagtttttt tttctttttt aaaacagaca       60

cagctactga gtgcaatgcc gcctccacag aaaatcccaa gcgtcagacc cttcaagcag      120

aggaaaagct tggcaatcag acaagaggaa gttgctggaa tccgggcaaa gttccccaac      180

aaaatcccgg tggtagtgga gcgctacccc agggagacgt tcctgccccc gctggacaaa      240

accaagttcc tggtcccgca ggagctgacc atgacccagt tcctcagcat catccggagc      300

cgcatggtcc tgagagccac ggaagccttt tacttgctgg tgaacaacaa gagcctggtc      360

agcatgagcg caaccatggc agagatctac agagactaca aggatgagga tggcttcgtg      420

tacatgacct acgcctccca ggagacattt ggctgcctgg agtcagcagc ccccagggat      480

gggagcagcc ttgaggacag accctgcaat cctctctagc ccatgtcggg aaggatgtgt      540

gctctgacag acgtgtcaga tgctggcaga agggattggt tttctcctgt gtatacagtg      600

gaggagtctg agaagcaggg atgcctgggg tgatcagctc caaccagtgg cagcagagtg      660

gtggctcttc ctagtttagt ttttgtgctc cgtgttcttg tgtccttcta agaaaaatgt      720

gggctgctct tgaaagttat ataattatca tttttttttt tttgaaacag ggtcttgctc      780

tattgcctag gctggagcac agtggcatga tcttggctca ctgcaacctc cgcctcctgg      840

gttcaagtga ttcttctgcc tccacccccc gagtggctgg tattacaagc acatgccacc      900

acaccaggct aatttttgta tttttagtag agacggggtt tcaccatgtt ggccaggctg      960

gtctcgaact cctgacctca ggtgatccac ccacctcggc ctcccaaagt gctgggatta     1020

caggcgtgag ccactgcatc cagccatata accgtattct aaataagaaa tggttggctt     1080

gtgtgatggt tttgtgtaat gagctagaga taatatttta agtgtcttct gtggtatatg     1140

tgggagggcc attaaggagt gggtttcact ccctgcatgt gggcaggtgt cc             1192


<210>  13
<211>  362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  13
taagctttaa aaacatgtaa aaaggacatt aaattgacat cttttttgtg ttaggtcacc       60

aaggagcagt gggacaccat agaagaactc atcaggaaga caaaaggttc ctaagaccac      120

tttggccttc atcttggtta cagaaaaggg aatagaaatg aaacaaatta tctctcatct      180

tttgactatt tcaagtctaa taaattctta attaacaaac attcattgaa tatgtattat      240

gtgccaggcc agtgatagcc attgtatatt caaagataaa taaaatgaaa tatagtcttc      300

aaaacattaa aaaaaaaagg agggcatggg gagagtaggt aaaggctcct ctttacctat      360

tt                                                                     362


<210>  14
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Met Lys Leu Pro Ala Arg Val Phe Phe Thr Leu Gly Ser Arg Leu Pro 
1               5                   10                  15      


Cys Gly Leu Ala Pro Arg Arg Phe Phe Ser Tyr Gly Thr Lys Ile Leu 
            20                  25                  30          


Tyr Gln Asn Thr Glu Ala Leu Gln Ser Lys Phe Phe Ser Pro Leu Gln 
        35                  40                  45              


Lys Ala Met Leu Pro Pro Asn Ser Phe Gln Gly Lys Val Ala Phe Ile 
    50                  55                  60                  


Thr Gly Gly Gly Thr Gly Leu Gly Lys Gly Met Thr Thr Leu Leu Ser 
65                  70                  75                  80  


Ser Leu Gly Ala Gln Cys Val Ile Ala Ser Arg Lys Met Asp Val Leu 
                85                  90                  95      


Lys Ala Thr Ala Glu Gln Ile Ser Ser Gln Thr Gly Asn Lys Val His 
            100                 105                 110         


Ala Ile Gln Cys Asp Val Arg Asp Pro Asp Met Val Gln Asn Thr Val 
        115                 120                 125             


Ser Glu Leu Ile Lys Val Ala Gly His Pro Asn Ile Val Ile Asn Asn 
    130                 135                 140                 


Ala Ala Gly Asn Phe Ile Ser Pro Thr Glu Arg Leu Ser Pro Asn Ala 
145                 150                 155                 160 


Trp Lys Thr Ile Thr Asp Ile Val Leu Asn Gly Thr Ala Phe Val Thr 
                165                 170                 175     


Leu Glu Ile Gly Lys Gln Leu Ile Lys Ala Gln Lys Gly Ala Ala Phe 
            180                 185                 190         


Leu Ser Ile Thr Thr Ile Tyr Ala Glu Thr Gly Ser Gly Phe Val Val 
        195                 200                 205             


Pro Ser Ala Ser Ala Lys Ala Gly Val Glu Ala Met Ser Lys Ser Leu 
    210                 215                 220                 


Ala Ala Glu Trp Gly Lys Tyr Gly Met Arg Phe Asn Val Ile Gln Pro 
225                 230                 235                 240 


Gly Pro Ile Lys Thr Lys Gly Ala Phe Ser Arg Leu Asp Pro Thr Gly 
                245                 250                 255     


Thr Phe Glu Lys Glu Met Ile Gly Arg Ile Pro Cys Gly Arg Leu Gly 
            260                 265                 270         


Thr Val Glu Glu Leu Ala Asn Leu Ala Ala Phe Leu Cys Ser Asp Tyr 
        275                 280                 285             


Ala Ser Trp Ile Asn Gly Ala Val Ile Lys Phe Asp Gly Gly Glu Glu 
    290                 295                 300                 


Val Leu Ile Ser Gly Glu Phe Asn Asp Leu Arg Lys Val Thr Lys Glu 
305                 310                 315                 320 


Gln Trp Asp Thr Ile Glu Glu Leu Ile Arg Lys Thr Lys Gly 
                325                 330                 


