                         SEQUENCE LISTING

<110>  MOMENTA PHARMACEUTICALS, INC.
 
<120>  GLYCOPROTEINS WITH ANTI-INFLAMMATORY PROPERTIES

<130>  50937-006WO2

<140>  PCT/US2013/052040
<141>  2013-07-25

<150>  61/768,027
<151>  2013-02-22

<150>  61/676,253
<151>  2012-07-26

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala Gly Ser Ser Pro Leu Leu Ala Met Glu Trp Ser His Pro 
            20                  25                  30          


Gln Phe Glu Lys Leu Glu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Ser Trp Ser His Pro Gln Phe Glu Lys His Ala His Ala His Ser Arg 
    50                  55                  60                  


Lys Asp His Leu Ile His Asn Val His Lys Glu Glu His Ala His Ala 
65                  70                  75                  80  


His Asn Lys Glu Leu Gly Thr Ala Val Phe Gln Gly Pro Met Arg Arg 
                85                  90                  95      


Ala Ile Arg Gly Arg Ser Phe Gln Val Trp Asn Lys Asp Ser Ser Ser 
            100                 105                 110         


Lys Asn Leu Ile Pro Arg Leu Gln Lys Ile Trp Lys Asn Tyr Leu Ser 
        115                 120                 125             


Met Asn Lys Tyr Lys Val Ser Tyr Lys Gly Pro Gly Pro Gly Ile Lys 
    130                 135                 140                 


Phe Ser Ala Glu Ala Leu Arg Cys His Leu Arg Asp His Val Asn Val 
145                 150                 155                 160 


Ser Met Val Glu Val Thr Asp Phe Pro Phe Asn Thr Ser Glu Trp Glu 
                165                 170                 175     


Gly Tyr Leu Pro Lys Glu Ser Ile Arg Thr Lys Ala Gly Pro Trp Gly 
            180                 185                 190         


Arg Cys Ala Val Val Ser Ser Ala Gly Ser Leu Lys Ser Ser Gln Leu 
        195                 200                 205             


Gly Arg Glu Ile Asp Asp His Asp Ala Val Leu Arg Phe Asn Gly Ala 
    210                 215                 220                 


Pro Thr Ala Asn Phe Gln Gln Asp Val Gly Thr Lys Thr Thr Ile Arg 
225                 230                 235                 240 


Leu Met Asn Ser Gln Leu Val Thr Thr Glu Lys Arg Phe Leu Lys Asp 
                245                 250                 255     


Ser Leu Tyr Asn Glu Gly Ile Leu Ile Val Trp Asp Pro Ser Val Tyr 
            260                 265                 270         


His Ser Asp Ile Pro Lys Trp Tyr Gln Asn Pro Asp Tyr Asn Phe Phe 
        275                 280                 285             


Asn Asn Tyr Lys Thr Tyr Arg Lys Leu His Pro Asn Gln Pro Phe Tyr 
    290                 295                 300                 


Ile Leu Lys Pro Gln Met Pro Trp Glu Leu Trp Asp Ile Leu Gln Glu 
305                 310                 315                 320 


Ile Ser Pro Glu Glu Ile Gln Pro Asn Pro Pro Ser Ser Gly Met Leu 
                325                 330                 335     


Gly Ile Ile Ile Met Met Thr Leu Cys Asp Gln Val Asp Ile Tyr Glu 
            340                 345                 350         


Phe Leu Pro Ser Lys Arg Lys Thr Asp Val Cys Tyr Tyr Tyr Gln Lys 
        355                 360                 365             


Phe Phe Asp Ser Ala Cys Thr Met Gly Ala Tyr His Pro Leu Leu Tyr 
    370                 375                 380                 


Glu Lys Asn Leu Val Lys His Leu Asn Gln Gly Thr Asp Glu Asp Ile 
385                 390                 395                 400 


Tyr Leu Leu Gly Lys Ala Thr Leu Pro Gly Phe Arg Thr Ile His Cys 
                405                 410                 415     


Pro Gly 
        


<210>  2
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Ser Tyr Tyr Asp Ser Phe Lys Leu Gln Thr Lys Glu Phe Gln Val 
1               5                   10                  15      


Leu Lys Ser Leu Gly Lys Leu Ala Met Gly Ser Asp Ser Gln Ser Val 
            20                  25                  30          


Ser Ser Ser Ser Thr Gln Asp Pro His Arg Gly Arg Gln Thr Leu Gly 
        35                  40                  45              


Ser Leu Arg Gly Leu Ala Lys Ala Lys Pro Glu Ala Ser Phe Gln Val 
    50                  55                  60                  


Trp Asn Lys Asp Ser Ser Ser Lys Asn Leu Ile Pro Arg Leu Gln Lys 
65                  70                  75                  80  


Ile Trp Lys Asn Tyr Leu Ser Met Asn Lys Tyr Lys Val Ser Tyr Lys 
                85                  90                  95      


Gly Pro Gly Pro Gly Ile Lys Phe Ser Ala Glu Ala Leu Arg Cys His 
            100                 105                 110         


Leu Arg Asp His Val Asn Val Ser Met Val Glu Val Thr Asp Phe Pro 
        115                 120                 125             


Phe Asn Thr Ser Glu Trp Glu Gly Tyr Leu Pro Lys Glu Ser Ile Arg 
    130                 135                 140                 


Thr Lys Ala Gly Pro Trp Gly Arg Cys Ala Val Val Ser Ser Ala Gly 
145                 150                 155                 160 


Ser Leu Lys Ser Ser Gln Leu Gly Arg Glu Ile Asp Asp His Asp Ala 
                165                 170                 175     


Val Leu Arg Phe Asn Gly Ala Pro Thr Ala Asn Phe Gln Gln Asp Val 
            180                 185                 190         


Gly Thr Lys Thr Thr Ile Arg Leu Met Asn Ser Gln Leu Val Thr Thr 
        195                 200                 205             


Glu Lys Arg Phe Leu Lys Asp Ser Leu Tyr Asn Glu Gly Ile Leu Ile 
    210                 215                 220                 


Val Trp Asp Pro Ser Val Tyr His Ser Asp Ile Pro Lys Trp Tyr Gln 
225                 230                 235                 240 


Asn Pro Asp Tyr Asn Phe Phe Asn Asn Tyr Lys Thr Tyr Arg Lys Leu 
                245                 250                 255     


His Pro Asn Gln Pro Phe Tyr Ile Leu Lys Pro Gln Met Pro Trp Glu 
            260                 265                 270         


Leu Trp Asp Ile Leu Gln Glu Ile Ser Pro Glu Glu Ile Gln Pro Asn 
        275                 280                 285             


Pro Pro Ser Ser Gly Met Leu Gly Ile Ile Ile Met Met Thr Leu Cys 
    290                 295                 300                 


Asp Gln Val Asp Ile Tyr Glu Phe Leu Pro Ser Lys Arg Lys Thr Asp 
305                 310                 315                 320 


Val Cys Tyr Tyr Tyr Gln Lys Phe Phe Asp Ser Ala Cys Thr Met Gly 
                325                 330                 335     


Ala Tyr His Pro Leu Leu Tyr Glu Lys Asn Leu Val Lys His Leu Asn 
            340                 345                 350         


Gln Gly Thr Asp Glu Asp Ile Tyr Leu Leu Gly Lys Ala Thr Leu Pro 
        355                 360                 365             


Gly Phe Arg Thr Ile His Cys 
    370                 375 


<210>  3
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ile His Thr Asn Leu Lys Lys Lys Phe Ser Tyr Phe Ile Leu Ala 
1               5                   10                  15      


Phe Leu Leu Phe Ala Leu Ile Cys Val Trp Lys Lys Gly Ser Tyr Glu 
            20                  25                  30          


Ala Leu Lys Leu Gln Ala Lys Glu Phe Gln Val Thr Lys Ser Leu Glu 
        35                  40                  45              


Lys Leu Ala Ile Gly Ser Gly Ser Gln Ser Thr Ser Ala Ser Ile Lys 
    50                  55                  60                  


Gln Asp Ser Lys Pro Gly Ser Gln Val Leu Ser His Leu Arg Val Thr 
65                  70                  75                  80  


Ala Lys Val Lys Pro Gln Ser Pro Tyr Gln Val Trp Asp Lys Asn Ser 
                85                  90                  95      


Ser Ser Lys Asn Leu Asn Pro Arg Leu Gln Lys Ile Leu Lys Asn Tyr 
            100                 105                 110         


Leu Ser Met Asn Lys Tyr Lys Val Ser Tyr Lys Gly Pro Gly Pro Gly 
        115                 120                 125             


Val Lys Phe Ser Val Glu Ala Leu Arg Cys His Leu Arg Asp Arg Val 
    130                 135                 140                 


Asn Val Ser Met Ile Glu Ala Thr Asp Phe Pro Phe Asn Thr Thr Glu 
145                 150                 155                 160 


Trp Glu Gly Tyr Leu Pro Lys Glu Asn Phe Arg Thr Lys Ala Gly Pro 
                165                 170                 175     


Trp His Arg Cys Ala Val Val Ser Ser Ala Gly Ser Leu Lys Ser Ser 
            180                 185                 190         


His Leu Gly Lys Glu Ile Asp Ser His Asp Ala Val Leu Arg Phe Asn 
        195                 200                 205             


Gly Ala Pro Val Ala Asp Phe Gln Gln Asp Val Gly Met Lys Thr Thr 
    210                 215                 220                 


Ile Arg Leu Met Asn Ser Gln Leu Ile Thr Thr Glu Lys Gln Phe Leu 
225                 230                 235                 240 


Lys Asp Ser Leu Tyr Asn Glu Gly Ile Leu Ile Val Trp Asp Pro Ser 
                245                 250                 255     


Leu Tyr His Ala Asp Ile Pro Asn Trp Tyr Lys Lys Pro Asp Tyr Asn 
            260                 265                 270         


Phe Phe Glu Thr Tyr Lys Ser Tyr Arg Lys Leu Tyr Pro Ser Gln Pro 
        275                 280                 285             


Phe Tyr Ile Leu Arg Pro Gln Met Pro Trp Glu Leu Trp Asp Ile Ile 
    290                 295                 300                 


Gln Glu Ile Ala Pro Asp Arg Ile Gln Pro Asn Pro Pro Ser Ser Gly 
305                 310                 315                 320 


Met Leu Gly Ile Ile Ile Met Met Thr Leu Cys Asp Gln Val Asp Val 
                325                 330                 335     


Tyr Glu Phe Leu Pro Ser Lys Arg Lys Thr Asp Val Cys Tyr Tyr His 
            340                 345                 350         


Gln Lys Phe Phe Asp Ser Ala Cys Thr Met Gly Ala Tyr His Pro Leu 
        355                 360                 365             


Leu Phe Glu Lys Asn Met Val Lys Gln Leu Asn Glu Gly Thr Asp Glu 
    370                 375                 380                 


Asp Ile Tyr Ile Phe Gly Lys Ala Thr Leu Ser Gly Phe Arg Thr Ile 
385                 390                 395                 400 


His Cys 
        


