                         SEQUENCE LISTING

<110>  Cedars-Sinai Medical Center
       Berois, Nora
       Touya, Diego
       Varangot, Mario
       Osinaga, Eduardo
 
<120>  A Novel Method to Detect Resistance to Chemotherapy In Patients 
       with Lung Cancer

<130>  065472-000382WO00

<150>  US 61/675,276
<151>  2012-07-24

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  1671
<212>  DNA
<213>  Homo sapiens (GalNAc-T13 wildtpe)


<220>
<221>  CDS
<222>  (1)..(1671)

<400>  1
atg agg aga ttt gtc tac tgc aag gtg gtt cta gcc act tcg ctg atg         48
Met Arg Arg Phe Val Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Met           
1               5                   10                  15                

tgg gtt ctt gtt gat gtc ttc tta ctg ctg tac ttc agt gaa tgt aac         96
Trp Val Leu Val Asp Val Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn           
            20                  25                  30                    

aaa tgt gat gac aag aag gag aga tct ctg ctg cct gca ttg agg gct        144
Lys Cys Asp Asp Lys Lys Glu Arg Ser Leu Leu Pro Ala Leu Arg Ala           
        35                  40                  45                        

gtt att tca aga aac caa gaa ggg cca gga gaa atg gga aaa gct gtg        192
Val Ile Ser Arg Asn Gln Glu Gly Pro Gly Glu Met Gly Lys Ala Val           
    50                  55                  60                            

ttg att cct aaa gat gac cag gag aaa atg aaa gag ctg ttt aaa atc        240
Leu Ile Pro Lys Asp Asp Gln Glu Lys Met Lys Glu Leu Phe Lys Ile           
65                  70                  75                  80            

aat cag ttt aac ctt atg gcc agt gat ttg att gcc ctt aat aga agt        288
Asn Gln Phe Asn Leu Met Ala Ser Asp Leu Ile Ala Leu Asn Arg Ser           
                85                  90                  95                

ctg cca gat gta aga tta gaa gga tgt aag aca aaa gtc tac cct gat        336
Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro Asp           
            100                 105                 110                   

gaa ctt cca aac aca agt gta gtc att gtg ttt cat aat gaa gct tgg        384
Glu Leu Pro Asn Thr Ser Val Val Ile Val Phe His Asn Glu Ala Trp           
        115                 120                 125                       

agc act ctc ctt aga act gtt tac agt gtg ata aat cgt tcc cca cac        432
Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Ile Asn Arg Ser Pro His           
    130                 135                 140                           

tat cta ctc tca gag gtc atc ttg gta gat gat gcc agt gaa aga gat        480
Tyr Leu Leu Ser Glu Val Ile Leu Val Asp Asp Ala Ser Glu Arg Asp           
145                 150                 155                 160           

ttt ctc aag ttg aca tta gag aat tac gtg aaa aat tta gaa gtg cca        528
Phe Leu Lys Leu Thr Leu Glu Asn Tyr Val Lys Asn Leu Glu Val Pro           
                165                 170                 175               

gta aaa att att agg atg gaa gaa cgc tct ggg tta ata cgt gcc cgt        576
Val Lys Ile Ile Arg Met Glu Glu Arg Ser Gly Leu Ile Arg Ala Arg           
            180                 185                 190                   

ctt cga gga gca gct gct tca aaa ggg cag gtc ata act ttt ctt gat        624
Leu Arg Gly Ala Ala Ala Ser Lys Gly Gln Val Ile Thr Phe Leu Asp           
        195                 200                 205                       

gca cac tgt gaa tgc acg tta gga tgg ctg gag cct ttg ctg gca aga        672
Ala His Cys Glu Cys Thr Leu Gly Trp Leu Glu Pro Leu Leu Ala Arg           
    210                 215                 220                           

ata aag gaa gac agg aaa acg gtt gtc tgc cct atc att gat gtg att        720
Ile Lys Glu Asp Arg Lys Thr Val Val Cys Pro Ile Ile Asp Val Ile           
225                 230                 235                 240           

agt gat gat act ttt gaa tat atg gct ggg tca gac atg act tat ggg        768
Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr Gly           
                245                 250                 255               

ggt ttt aac tgg aaa ctg aat ttc cgc tgg tat cct gtt ccc caa aga        816
Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln Arg           
            260                 265                 270                   

gaa atg gac agg agg aaa gga gac aga aca tta cct gtc agg acc cct        864
Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Thr Pro           
        275                 280                 285                       

act atg gct ggt ggc cta ttt tct att gac aga aac tac ttt gaa gag        912
Thr Met Ala Gly Gly Leu Phe Ser Ile Asp Arg Asn Tyr Phe Glu Glu           
    290                 295                 300                           

ata gga act tac gat gca gga atg gat atc tgg ggt gga gag aat ctt        960
Ile Gly Thr Tyr Asp Ala Gly Met Asp Ile Trp Gly Gly Glu Asn Leu           
305                 310                 315                 320           

gaa atg tct ttt agg att tgg caa tgt gga ggc tcc ttg gag att gtt       1008
Glu Met Ser Phe Arg Ile Trp Gln Cys Gly Gly Ser Leu Glu Ile Val           
                325                 330                 335               

act tgc tcc cat gtt ggt cat gtt ttt cgg aag gca act cca tac act       1056
Thr Cys Ser His Val Gly His Val Phe Arg Lys Ala Thr Pro Tyr Thr           
            340                 345                 350                   

ttt cct ggt ggc act ggt cat gtc atc aac aag aac aac agg aga ctg       1104
Phe Pro Gly Gly Thr Gly His Val Ile Asn Lys Asn Asn Arg Arg Leu           
        355                 360                 365                       

gca gaa gtt tgg atg gat gaa ttt aaa gat ttc ttc tac atc ata tcc       1152
Ala Glu Val Trp Met Asp Glu Phe Lys Asp Phe Phe Tyr Ile Ile Ser           
    370                 375                 380                           

cca ggt gtt gtc aaa gtg gat tat gga gat gtg tca gtc aga aaa aca       1200
Pro Gly Val Val Lys Val Asp Tyr Gly Asp Val Ser Val Arg Lys Thr           
385                 390                 395                 400           

cta aga gaa aat ctg aag tgt aag ccc ttt tct tgg tac cta gaa aac       1248
Leu Arg Glu Asn Leu Lys Cys Lys Pro Phe Ser Trp Tyr Leu Glu Asn           
                405                 410                 415               

atc tat ccg gac tcc cag atc cca aga cgt tat tac tca ctt ggt gag       1296
Ile Tyr Pro Asp Ser Gln Ile Pro Arg Arg Tyr Tyr Ser Leu Gly Glu           
            420                 425                 430                   

ata aga aat gtt gaa acc aat cag tgt tta gac aac atg ggc cgc aag       1344
Ile Arg Asn Val Glu Thr Asn Gln Cys Leu Asp Asn Met Gly Arg Lys           
        435                 440                 445                       

gaa aat gaa aaa gtg ggt ata ttc aac tgt cat ggt atg gga gga aat       1392
Glu Asn Glu Lys Val Gly Ile Phe Asn Cys His Gly Met Gly Gly Asn           
    450                 455                 460                           

cag gta ttt tct tac act gct gac aaa gaa atc cga acc gat gac ttg       1440
Gln Val Phe Ser Tyr Thr Ala Asp Lys Glu Ile Arg Thr Asp Asp Leu           
465                 470                 475                 480           

tgc ttg gat gtt tct aga ctc aat gga cct gta atc atg tta aaa tgc       1488
Cys Leu Asp Val Ser Arg Leu Asn Gly Pro Val Ile Met Leu Lys Cys           
                485                 490                 495               

cac cat atg aga gga aat cag tta tgg gaa tat gat gct gag aga ctc       1536
His His Met Arg Gly Asn Gln Leu Trp Glu Tyr Asp Ala Glu Arg Leu           
            500                 505                 510                   

acg ttg cga cat gtt aac agt aac caa tgt ctc gat gaa cct tct gaa       1584
Thr Leu Arg His Val Asn Ser Asn Gln Cys Leu Asp Glu Pro Ser Glu           
        515                 520                 525                       

gaa gac aaa atg gtg cct aca atg cag gac tgt agt gga agc aga tcc       1632
Glu Asp Lys Met Val Pro Thr Met Gln Asp Cys Ser Gly Ser Arg Ser           
    530                 535                 540                           

caa cag tgg ctg cta agg aac atg acc ttg ggc aca tga                   1671
Gln Gln Trp Leu Leu Arg Asn Met Thr Leu Gly Thr                           
545                 550                 555                               


<210>  2
<211>  556
<212>  PRT
<213>  Homo sapiens (GalNAc-T13 wildtpe)

<400>  2

Met Arg Arg Phe Val Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Met 
1               5                   10                  15      


Trp Val Leu Val Asp Val Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn 
            20                  25                  30          


Lys Cys Asp Asp Lys Lys Glu Arg Ser Leu Leu Pro Ala Leu Arg Ala 
        35                  40                  45              


Val Ile Ser Arg Asn Gln Glu Gly Pro Gly Glu Met Gly Lys Ala Val 
    50                  55                  60                  


Leu Ile Pro Lys Asp Asp Gln Glu Lys Met Lys Glu Leu Phe Lys Ile 
65                  70                  75                  80  


Asn Gln Phe Asn Leu Met Ala Ser Asp Leu Ile Ala Leu Asn Arg Ser 
                85                  90                  95      


Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro Asp 
            100                 105                 110         


Glu Leu Pro Asn Thr Ser Val Val Ile Val Phe His Asn Glu Ala Trp 
        115                 120                 125             


Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Ile Asn Arg Ser Pro His 
    130                 135                 140                 


Tyr Leu Leu Ser Glu Val Ile Leu Val Asp Asp Ala Ser Glu Arg Asp 
145                 150                 155                 160 


Phe Leu Lys Leu Thr Leu Glu Asn Tyr Val Lys Asn Leu Glu Val Pro 
                165                 170                 175     


Val Lys Ile Ile Arg Met Glu Glu Arg Ser Gly Leu Ile Arg Ala Arg 
            180                 185                 190         


Leu Arg Gly Ala Ala Ala Ser Lys Gly Gln Val Ile Thr Phe Leu Asp 
        195                 200                 205             


Ala His Cys Glu Cys Thr Leu Gly Trp Leu Glu Pro Leu Leu Ala Arg 
    210                 215                 220                 


Ile Lys Glu Asp Arg Lys Thr Val Val Cys Pro Ile Ile Asp Val Ile 
225                 230                 235                 240 


Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr Gly 
                245                 250                 255     


Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln Arg 
            260                 265                 270         


Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Thr Pro 
        275                 280                 285             


Thr Met Ala Gly Gly Leu Phe Ser Ile Asp Arg Asn Tyr Phe Glu Glu 
    290                 295                 300                 


Ile Gly Thr Tyr Asp Ala Gly Met Asp Ile Trp Gly Gly Glu Asn Leu 
305                 310                 315                 320 


Glu Met Ser Phe Arg Ile Trp Gln Cys Gly Gly Ser Leu Glu Ile Val 
                325                 330                 335     


Thr Cys Ser His Val Gly His Val Phe Arg Lys Ala Thr Pro Tyr Thr 
            340                 345                 350         


Phe Pro Gly Gly Thr Gly His Val Ile Asn Lys Asn Asn Arg Arg Leu 
        355                 360                 365             


Ala Glu Val Trp Met Asp Glu Phe Lys Asp Phe Phe Tyr Ile Ile Ser 
    370                 375                 380                 


Pro Gly Val Val Lys Val Asp Tyr Gly Asp Val Ser Val Arg Lys Thr 
385                 390                 395                 400 


Leu Arg Glu Asn Leu Lys Cys Lys Pro Phe Ser Trp Tyr Leu Glu Asn 
                405                 410                 415     


Ile Tyr Pro Asp Ser Gln Ile Pro Arg Arg Tyr Tyr Ser Leu Gly Glu 
            420                 425                 430         


Ile Arg Asn Val Glu Thr Asn Gln Cys Leu Asp Asn Met Gly Arg Lys 
        435                 440                 445             


Glu Asn Glu Lys Val Gly Ile Phe Asn Cys His Gly Met Gly Gly Asn 
    450                 455                 460                 


Gln Val Phe Ser Tyr Thr Ala Asp Lys Glu Ile Arg Thr Asp Asp Leu 
465                 470                 475                 480 


Cys Leu Asp Val Ser Arg Leu Asn Gly Pro Val Ile Met Leu Lys Cys 
                485                 490                 495     


His His Met Arg Gly Asn Gln Leu Trp Glu Tyr Asp Ala Glu Arg Leu 
            500                 505                 510         


Thr Leu Arg His Val Asn Ser Asn Gln Cys Leu Asp Glu Pro Ser Glu 
        515                 520                 525             


Glu Asp Lys Met Val Pro Thr Met Gln Asp Cys Ser Gly Ser Arg Ser 
    530                 535                 540                 


Gln Gln Trp Leu Leu Arg Asn Met Thr Leu Gly Thr 
545                 550                 555     


<210>  3
<211>  1572
<212>  DNA
<213>  Homo sapiens (GalNAc-T13DelEx9)


<220>
<221>  CDS
<222>  (1)..(1572)

<400>  3
atg agg aga ttt gtc tac tgc aag gtg gtt cta gcc act tcg ctg atg         48
Met Arg Arg Phe Val Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Met           
1               5                   10                  15                

tgg gtt ctt gtt gat gtc ttc tta ctg ctg tac ttc agt gaa tgt aac         96
Trp Val Leu Val Asp Val Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn           
            20                  25                  30                    

aaa tgt gat gac aag aag gag aga tct ctg ctg cct gca ttg agg gct        144
Lys Cys Asp Asp Lys Lys Glu Arg Ser Leu Leu Pro Ala Leu Arg Ala           
        35                  40                  45                        

gtt att tca aga aac caa gaa ggg cca gga gaa atg gga aaa gct gtg        192
Val Ile Ser Arg Asn Gln Glu Gly Pro Gly Glu Met Gly Lys Ala Val           
    50                  55                  60                            

ttg att cct aaa gat gac cag gag aaa atg aaa gag ctg ttt aaa atc        240
Leu Ile Pro Lys Asp Asp Gln Glu Lys Met Lys Glu Leu Phe Lys Ile           
65                  70                  75                  80            

aat cag ttt aac ctt atg gcc agt gat ttg att gcc ctt aat aga agt        288
Asn Gln Phe Asn Leu Met Ala Ser Asp Leu Ile Ala Leu Asn Arg Ser           
                85                  90                  95                

ctg cca gat gta aga tta gaa gga tgt aag aca aaa gtc tac cct gat        336
Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro Asp           
            100                 105                 110                   

gaa ctt cca aac aca agt gta gtc att gtg ttt cat aat gaa gct tgg        384
Glu Leu Pro Asn Thr Ser Val Val Ile Val Phe His Asn Glu Ala Trp           
        115                 120                 125                       

agc act ctc ctt aga act gtt tac agt gtg ata aat cgt tcc cca cac        432
Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Ile Asn Arg Ser Pro His           
    130                 135                 140                           

tat cta ctc tca gag gtc atc ttg gta gat gat gcc agt gaa aga gat        480
Tyr Leu Leu Ser Glu Val Ile Leu Val Asp Asp Ala Ser Glu Arg Asp           
145                 150                 155                 160           

ttt ctc aag ttg aca tta gag aat tac gtg aaa aat tta gaa gtg cca        528
Phe Leu Lys Leu Thr Leu Glu Asn Tyr Val Lys Asn Leu Glu Val Pro           
                165                 170                 175               

gta aaa att att agg atg gaa gaa cgc tct ggg tta ata cgt gcc cgt        576
Val Lys Ile Ile Arg Met Glu Glu Arg Ser Gly Leu Ile Arg Ala Arg           
            180                 185                 190                   

ctt cga gga gca gct gct tca aaa ggg cag gtc ata act ttt ctt gat        624
Leu Arg Gly Ala Ala Ala Ser Lys Gly Gln Val Ile Thr Phe Leu Asp           
        195                 200                 205                       

gca cac tgt gaa tgc acg tta gga tgg ctg gag cct ttg ctg gca aga        672
Ala His Cys Glu Cys Thr Leu Gly Trp Leu Glu Pro Leu Leu Ala Arg           
    210                 215                 220                           

ata aag gaa gac agg aaa acg gtt gtc tgc cct atc att gat gtg att        720
Ile Lys Glu Asp Arg Lys Thr Val Val Cys Pro Ile Ile Asp Val Ile           
225                 230                 235                 240           

agt gat gat act ttt gaa tat atg gct ggg tca gac atg act tat ggg        768
Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr Gly           
                245                 250                 255               

ggt ttt aac tgg aaa ctg aat ttc cgc tgg tat cct gtt ccc caa aga        816
Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln Arg           
            260                 265                 270                   

gaa atg gac agg agg aaa gga gac aga aca tta cct gtc agg acc cct        864
Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Thr Pro           
        275                 280                 285                       

act atg gct ggt ggc cta ttt tct att gac aga aac tac ttt gaa gag        912
Thr Met Ala Gly Gly Leu Phe Ser Ile Asp Arg Asn Tyr Phe Glu Glu           
    290                 295                 300                           

ata gga act tac gat gca gga atg gat atc tgg ggt gga gag aat ctt        960
Ile Gly Thr Tyr Asp Ala Gly Met Asp Ile Trp Gly Gly Glu Asn Leu           
305                 310                 315                 320           

gaa atg tct ttt agg att tgg caa tgt gga ggc tcc ttg gag att gtt       1008
Glu Met Ser Phe Arg Ile Trp Gln Cys Gly Gly Ser Leu Glu Ile Val           
                325                 330                 335               

act tgc tcc cat gtt ggt cat gtt ttt cgg aag gca act cca tac act       1056
Thr Cys Ser His Val Gly His Val Phe Arg Lys Ala Thr Pro Tyr Thr           
            340                 345                 350                   

ttt cct ggt ggc act ggt cat gtc atc aac aag aac aac agg aga ctg       1104
Phe Pro Gly Gly Thr Gly His Val Ile Asn Lys Asn Asn Arg Arg Leu           
        355                 360                 365                       

gca gaa gtt tgg atg gat gaa ttt aaa gat ttc ttc tac atc ata tcc       1152
Ala Glu Val Trp Met Asp Glu Phe Lys Asp Phe Phe Tyr Ile Ile Ser           
    370                 375                 380                           

cca ggt gtt gtc aaa gtg gat tat gga gat gtg tca gtc aga aaa aca       1200
Pro Gly Val Val Lys Val Asp Tyr Gly Asp Val Ser Val Arg Lys Thr           
385                 390                 395                 400           

cta aga gaa aat ctg aag tgt aag ccc ttt tct tgg tac cta gaa aac       1248
Leu Arg Glu Asn Leu Lys Cys Lys Pro Phe Ser Trp Tyr Leu Glu Asn           
                405                 410                 415               

atc tat ccg gac tcc cag atc cca aga cgt tat tac tca ctt ggt gag       1296
Ile Tyr Pro Asp Ser Gln Ile Pro Arg Arg Tyr Tyr Ser Leu Gly Glu           
            420                 425                 430                   

gta ttt tct tac act gct gac aaa gaa atc cga acc gat gac ttg tgc       1344
Val Phe Ser Tyr Thr Ala Asp Lys Glu Ile Arg Thr Asp Asp Leu Cys           
        435                 440                 445                       

ttg gat gtt tct aga ctc aat gga cct gta atc atg tta aaa tgc cac       1392
Leu Asp Val Ser Arg Leu Asn Gly Pro Val Ile Met Leu Lys Cys His           
    450                 455                 460                           

cat atg aga gga aat cag tta tgg gaa tat gat gct gag aga ctc acg       1440
His Met Arg Gly Asn Gln Leu Trp Glu Tyr Asp Ala Glu Arg Leu Thr           
465                 470                 475                 480           

ttg cga cat gtt aac agt aac caa tgt ctc gat gaa cct tct gaa gaa       1488
Leu Arg His Val Asn Ser Asn Gln Cys Leu Asp Glu Pro Ser Glu Glu           
                485                 490                 495               

gac aaa atg gtg cct aca atg cag gac tgt agt gga agc aga tcc caa       1536
Asp Lys Met Val Pro Thr Met Gln Asp Cys Ser Gly Ser Arg Ser Gln           
            500                 505                 510                   

cag tgg ctg cta agg aac atg acc ttg ggc aca tga                       1572
Gln Trp Leu Leu Arg Asn Met Thr Leu Gly Thr                               
        515                 520                                           


<210>  4
<211>  523
<212>  PRT
<213>  Homo sapiens (GalNAc-T13DelEx9)

<400>  4

Met Arg Arg Phe Val Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Met 
1               5                   10                  15      


Trp Val Leu Val Asp Val Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn 
            20                  25                  30          


Lys Cys Asp Asp Lys Lys Glu Arg Ser Leu Leu Pro Ala Leu Arg Ala 
        35                  40                  45              


Val Ile Ser Arg Asn Gln Glu Gly Pro Gly Glu Met Gly Lys Ala Val 
    50                  55                  60                  


Leu Ile Pro Lys Asp Asp Gln Glu Lys Met Lys Glu Leu Phe Lys Ile 
65                  70                  75                  80  


Asn Gln Phe Asn Leu Met Ala Ser Asp Leu Ile Ala Leu Asn Arg Ser 
                85                  90                  95      


Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro Asp 
            100                 105                 110         


Glu Leu Pro Asn Thr Ser Val Val Ile Val Phe His Asn Glu Ala Trp 
        115                 120                 125             


Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Ile Asn Arg Ser Pro His 
    130                 135                 140                 


Tyr Leu Leu Ser Glu Val Ile Leu Val Asp Asp Ala Ser Glu Arg Asp 
145                 150                 155                 160 


Phe Leu Lys Leu Thr Leu Glu Asn Tyr Val Lys Asn Leu Glu Val Pro 
                165                 170                 175     


Val Lys Ile Ile Arg Met Glu Glu Arg Ser Gly Leu Ile Arg Ala Arg 
            180                 185                 190         


Leu Arg Gly Ala Ala Ala Ser Lys Gly Gln Val Ile Thr Phe Leu Asp 
        195                 200                 205             


Ala His Cys Glu Cys Thr Leu Gly Trp Leu Glu Pro Leu Leu Ala Arg 
    210                 215                 220                 


Ile Lys Glu Asp Arg Lys Thr Val Val Cys Pro Ile Ile Asp Val Ile 
225                 230                 235                 240 


Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr Gly 
                245                 250                 255     


Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln Arg 
            260                 265                 270         


Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Thr Pro 
        275                 280                 285             


Thr Met Ala Gly Gly Leu Phe Ser Ile Asp Arg Asn Tyr Phe Glu Glu 
    290                 295                 300                 


Ile Gly Thr Tyr Asp Ala Gly Met Asp Ile Trp Gly Gly Glu Asn Leu 
305                 310                 315                 320 


Glu Met Ser Phe Arg Ile Trp Gln Cys Gly Gly Ser Leu Glu Ile Val 
                325                 330                 335     


Thr Cys Ser His Val Gly His Val Phe Arg Lys Ala Thr Pro Tyr Thr 
            340                 345                 350         


Phe Pro Gly Gly Thr Gly His Val Ile Asn Lys Asn Asn Arg Arg Leu 
        355                 360                 365             


Ala Glu Val Trp Met Asp Glu Phe Lys Asp Phe Phe Tyr Ile Ile Ser 
    370                 375                 380                 


Pro Gly Val Val Lys Val Asp Tyr Gly Asp Val Ser Val Arg Lys Thr 
385                 390                 395                 400 


Leu Arg Glu Asn Leu Lys Cys Lys Pro Phe Ser Trp Tyr Leu Glu Asn 
                405                 410                 415     


Ile Tyr Pro Asp Ser Gln Ile Pro Arg Arg Tyr Tyr Ser Leu Gly Glu 
            420                 425                 430         


Val Phe Ser Tyr Thr Ala Asp Lys Glu Ile Arg Thr Asp Asp Leu Cys 
        435                 440                 445             


Leu Asp Val Ser Arg Leu Asn Gly Pro Val Ile Met Leu Lys Cys His 
    450                 455                 460                 


His Met Arg Gly Asn Gln Leu Trp Glu Tyr Asp Ala Glu Arg Leu Thr 
465                 470                 475                 480 


Leu Arg His Val Asn Ser Asn Gln Cys Leu Asp Glu Pro Ser Glu Glu 
                485                 490                 495     


Asp Lys Met Val Pro Thr Met Gln Asp Cys Ser Gly Ser Arg Ser Gln 
            500                 505                 510         


Gln Trp Leu Leu Arg Asn Met Thr Leu Gly Thr 
        515                 520             


<210>  5
<211>  1632
<212>  DNA
<213>  Homo sapiens (GalNAc-T13Del39bpEx9)


<220>
<221>  CDS
<222>  (1)..(1632)

<400>  5
atg agg aga ttt gtc tac tgc aag gtg gtt cta gcc act tcg ctg atg         48
Met Arg Arg Phe Val Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Met           
1               5                   10                  15                

tgg gtt ctt gtt gat gtc ttc tta ctg ctg tac ttc agt gaa tgt aac         96
Trp Val Leu Val Asp Val Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn           
            20                  25                  30                    

aaa tgt gat gac aag aag gag aga tct ctg ctg cct gca ttg agg gct        144
Lys Cys Asp Asp Lys Lys Glu Arg Ser Leu Leu Pro Ala Leu Arg Ala           
        35                  40                  45                        

gtt att tca aga aac caa gaa ggg cca gga gaa atg gga aaa gct gtg        192
Val Ile Ser Arg Asn Gln Glu Gly Pro Gly Glu Met Gly Lys Ala Val           
    50                  55                  60                            

ttg att cct aaa gat gac cag gag aaa atg aaa gag ctg ttt aaa atc        240
Leu Ile Pro Lys Asp Asp Gln Glu Lys Met Lys Glu Leu Phe Lys Ile           
65                  70                  75                  80            

aat cag ttt aac ctt atg gcc agt gat ttg att gcc ctt aat aga agt        288
Asn Gln Phe Asn Leu Met Ala Ser Asp Leu Ile Ala Leu Asn Arg Ser           
                85                  90                  95                

ctg cca gat gta aga tta gaa gga tgt aag aca aaa gtc tac cct gat        336
Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro Asp           
            100                 105                 110                   

gaa ctt cca aac aca agt gta gtc att gtg ttt cat aat gaa gct tgg        384
Glu Leu Pro Asn Thr Ser Val Val Ile Val Phe His Asn Glu Ala Trp           
        115                 120                 125                       

agc act ctc ctt aga act gtt tac agt gtg ata aat cgt tcc cca cac        432
Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Ile Asn Arg Ser Pro His           
    130                 135                 140                           

tat cta ctc tca gag gtc atc ttg gta gat gat gcc agt gaa aga gat        480
Tyr Leu Leu Ser Glu Val Ile Leu Val Asp Asp Ala Ser Glu Arg Asp           
145                 150                 155                 160           

ttt ctc aag ttg aca tta gag aat tac gtg aaa aat tta gaa gtg cca        528
Phe Leu Lys Leu Thr Leu Glu Asn Tyr Val Lys Asn Leu Glu Val Pro           
                165                 170                 175               

gta aaa att att agg atg gaa gaa cgc tct ggg tta ata cgt gcc cgt        576
Val Lys Ile Ile Arg Met Glu Glu Arg Ser Gly Leu Ile Arg Ala Arg           
            180                 185                 190                   

ctt cga gga gca gct gct tca aaa ggg cag gtc ata act ttt ctt gat        624
Leu Arg Gly Ala Ala Ala Ser Lys Gly Gln Val Ile Thr Phe Leu Asp           
        195                 200                 205                       

gca cac tgt gaa tgc acg tta gga tgg ctg gag cct ttg ctg gca aga        672
Ala His Cys Glu Cys Thr Leu Gly Trp Leu Glu Pro Leu Leu Ala Arg           
    210                 215                 220                           

ata aag gaa gac agg aaa acg gtt gtc tgc cct atc att gat gtg att        720
Ile Lys Glu Asp Arg Lys Thr Val Val Cys Pro Ile Ile Asp Val Ile           
225                 230                 235                 240           

agt gat gat act ttt gaa tat atg gct ggg tca gac atg act tat ggg        768
Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr Gly           
                245                 250                 255               

ggt ttt aac tgg aaa ctg aat ttc cgc tgg tat cct gtt ccc caa aga        816
Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln Arg           
            260                 265                 270                   

gaa atg gac agg agg aaa gga gac aga aca tta cct gtc agg acc cct        864
Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Thr Pro           
        275                 280                 285                       

act atg gct ggt ggc cta ttt tct att gac aga aac tac ttt gaa gag        912
Thr Met Ala Gly Gly Leu Phe Ser Ile Asp Arg Asn Tyr Phe Glu Glu           
    290                 295                 300                           

ata gga act tac gat gca gga atg gat atc tgg ggt gga gag aat ctt        960
Ile Gly Thr Tyr Asp Ala Gly Met Asp Ile Trp Gly Gly Glu Asn Leu           
305                 310                 315                 320           

gaa atg tct ttt agg att tgg caa tgt gga ggc tcc ttg gag att gtt       1008
Glu Met Ser Phe Arg Ile Trp Gln Cys Gly Gly Ser Leu Glu Ile Val           
                325                 330                 335               

act tgc tcc cat gtt ggt cat gtt ttt cgg aag gca act cca tac act       1056
Thr Cys Ser His Val Gly His Val Phe Arg Lys Ala Thr Pro Tyr Thr           
            340                 345                 350                   

ttt cct ggt ggc act ggt cat gtc atc aac aag aac aac agg aga ctg       1104
Phe Pro Gly Gly Thr Gly His Val Ile Asn Lys Asn Asn Arg Arg Leu           
        355                 360                 365                       

gca gaa gtt tgg atg gat gaa ttt aaa gat ttc ttc tac atc ata tcc       1152
Ala Glu Val Trp Met Asp Glu Phe Lys Asp Phe Phe Tyr Ile Ile Ser           
    370                 375                 380                           

cca ggt gtt gtc aaa gtg gat tat gga gat gtg tca gtc aga aaa aca       1200
Pro Gly Val Val Lys Val Asp Tyr Gly Asp Val Ser Val Arg Lys Thr           
385                 390                 395                 400           

cta aga gaa aat ctg aag tgt aag ccc ttt tct tgg tac cta gaa aac       1248
Leu Arg Glu Asn Leu Lys Cys Lys Pro Phe Ser Trp Tyr Leu Glu Asn           
                405                 410                 415               

atc tat ccg gac tcc cag atc cca aga cgt tat tac tca ctt ggt gag       1296
Ile Tyr Pro Asp Ser Gln Ile Pro Arg Arg Tyr Tyr Ser Leu Gly Glu           
            420                 425                 430                   

ata aga aat gtt gaa acc aat cag tgt tta gac aac atg ggc cgc aag       1344
Ile Arg Asn Val Glu Thr Asn Gln Cys Leu Asp Asn Met Gly Arg Lys           
        435                 440                 445                       

gaa aat gaa aaa gta ttt tct tac act gct gac aaa gaa atc cga acc       1392
Glu Asn Glu Lys Val Phe Ser Tyr Thr Ala Asp Lys Glu Ile Arg Thr           
    450                 455                 460                           

gat gac ttg tgc ttg gat gtt tct aga ctc aat gga cct gta atc atg       1440
Asp Asp Leu Cys Leu Asp Val Ser Arg Leu Asn Gly Pro Val Ile Met           
465                 470                 475                 480           

tta aaa tgc cac cat atg aga gga aat cag tta tgg gaa tat gat gct       1488
Leu Lys Cys His His Met Arg Gly Asn Gln Leu Trp Glu Tyr Asp Ala           
                485                 490                 495               

gag aga ctc acg ttg cga cat gtt aac agt aac caa tgt ctc gat gaa       1536
Glu Arg Leu Thr Leu Arg His Val Asn Ser Asn Gln Cys Leu Asp Glu           
            500                 505                 510                   

cct tct gaa gaa gac aaa atg gtg cct aca atg cag gac tgt agt gga       1584
Pro Ser Glu Glu Asp Lys Met Val Pro Thr Met Gln Asp Cys Ser Gly           
        515                 520                 525                       

agc aga tcc caa cag tgg ctg cta agg aac atg acc ttg ggc aca tga       1632
Ser Arg Ser Gln Gln Trp Leu Leu Arg Asn Met Thr Leu Gly Thr               
    530                 535                 540                           


<210>  6
<211>  543
<212>  PRT
<213>  Homo sapiens (GalNAc-T13Del39bpEx9)

<400>  6

Met Arg Arg Phe Val Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Met 
1               5                   10                  15      


Trp Val Leu Val Asp Val Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn 
            20                  25                  30          


Lys Cys Asp Asp Lys Lys Glu Arg Ser Leu Leu Pro Ala Leu Arg Ala 
        35                  40                  45              


Val Ile Ser Arg Asn Gln Glu Gly Pro Gly Glu Met Gly Lys Ala Val 
    50                  55                  60                  


Leu Ile Pro Lys Asp Asp Gln Glu Lys Met Lys Glu Leu Phe Lys Ile 
65                  70                  75                  80  


Asn Gln Phe Asn Leu Met Ala Ser Asp Leu Ile Ala Leu Asn Arg Ser 
                85                  90                  95      


Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro Asp 
            100                 105                 110         


Glu Leu Pro Asn Thr Ser Val Val Ile Val Phe His Asn Glu Ala Trp 
        115                 120                 125             


Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Ile Asn Arg Ser Pro His 
    130                 135                 140                 


Tyr Leu Leu Ser Glu Val Ile Leu Val Asp Asp Ala Ser Glu Arg Asp 
145                 150                 155                 160 


Phe Leu Lys Leu Thr Leu Glu Asn Tyr Val Lys Asn Leu Glu Val Pro 
                165                 170                 175     


Val Lys Ile Ile Arg Met Glu Glu Arg Ser Gly Leu Ile Arg Ala Arg 
            180                 185                 190         


Leu Arg Gly Ala Ala Ala Ser Lys Gly Gln Val Ile Thr Phe Leu Asp 
        195                 200                 205             


Ala His Cys Glu Cys Thr Leu Gly Trp Leu Glu Pro Leu Leu Ala Arg 
    210                 215                 220                 


Ile Lys Glu Asp Arg Lys Thr Val Val Cys Pro Ile Ile Asp Val Ile 
225                 230                 235                 240 


Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr Gly 
                245                 250                 255     


Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln Arg 
            260                 265                 270         


Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Thr Pro 
        275                 280                 285             


Thr Met Ala Gly Gly Leu Phe Ser Ile Asp Arg Asn Tyr Phe Glu Glu 
    290                 295                 300                 


Ile Gly Thr Tyr Asp Ala Gly Met Asp Ile Trp Gly Gly Glu Asn Leu 
305                 310                 315                 320 


Glu Met Ser Phe Arg Ile Trp Gln Cys Gly Gly Ser Leu Glu Ile Val 
                325                 330                 335     


Thr Cys Ser His Val Gly His Val Phe Arg Lys Ala Thr Pro Tyr Thr 
            340                 345                 350         


Phe Pro Gly Gly Thr Gly His Val Ile Asn Lys Asn Asn Arg Arg Leu 
        355                 360                 365             


Ala Glu Val Trp Met Asp Glu Phe Lys Asp Phe Phe Tyr Ile Ile Ser 
    370                 375                 380                 


Pro Gly Val Val Lys Val Asp Tyr Gly Asp Val Ser Val Arg Lys Thr 
385                 390                 395                 400 


Leu Arg Glu Asn Leu Lys Cys Lys Pro Phe Ser Trp Tyr Leu Glu Asn 
                405                 410                 415     


Ile Tyr Pro Asp Ser Gln Ile Pro Arg Arg Tyr Tyr Ser Leu Gly Glu 
            420                 425                 430         


Ile Arg Asn Val Glu Thr Asn Gln Cys Leu Asp Asn Met Gly Arg Lys 
        435                 440                 445             


Glu Asn Glu Lys Val Phe Ser Tyr Thr Ala Asp Lys Glu Ile Arg Thr 
    450                 455                 460                 


Asp Asp Leu Cys Leu Asp Val Ser Arg Leu Asn Gly Pro Val Ile Met 
465                 470                 475                 480 


Leu Lys Cys His His Met Arg Gly Asn Gln Leu Trp Glu Tyr Asp Ala 
                485                 490                 495     


Glu Arg Leu Thr Leu Arg His Val Asn Ser Asn Gln Cys Leu Asp Glu 
            500                 505                 510         


Pro Ser Glu Glu Asp Lys Met Val Pro Thr Met Gln Asp Cys Ser Gly 
        515                 520                 525             


Ser Arg Ser Gln Gln Trp Leu Leu Arg Asn Met Thr Leu Gly Thr 
    530                 535                 540             


<210>  7
<211>  1869
<212>  DNA
<213>  Homo sapiens (GalNAc-T13DelEx10B)


<220>
<221>  CDS
<222>  (1)..(1719)

<400>  7
atg agg aga ttt gtc tac tgc aag gtg gtt cta gcc act tcg ctg atg         48
Met Arg Arg Phe Val Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Met           
1               5                   10                  15                

tgg gtt ctt gtt gat gtc ttc tta ctg ctg tac ttc agt gaa tgt aac         96
Trp Val Leu Val Asp Val Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn           
            20                  25                  30                    

aaa tgt gat gac aag aag gag aga tct ctg ctg cct gca ttg agg gct        144
Lys Cys Asp Asp Lys Lys Glu Arg Ser Leu Leu Pro Ala Leu Arg Ala           
        35                  40                  45                        

gtt att tca aga aac caa gaa ggg cca gga gaa atg gga aaa gct gtg        192
Val Ile Ser Arg Asn Gln Glu Gly Pro Gly Glu Met Gly Lys Ala Val           
    50                  55                  60                            

ttg att cct aaa gat gac cag gag aaa atg aaa gag ctg ttt aaa atc        240
Leu Ile Pro Lys Asp Asp Gln Glu Lys Met Lys Glu Leu Phe Lys Ile           
65                  70                  75                  80            

aat cag ttt aac ctt atg gcc agt gat ttg att gcc ctt aat aga agt        288
Asn Gln Phe Asn Leu Met Ala Ser Asp Leu Ile Ala Leu Asn Arg Ser           
                85                  90                  95                

ctg cca gat gta aga tta gaa gga tgt aag aca aaa gtc tac cct gat        336
Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro Asp           
            100                 105                 110                   

gaa ctt cca aac aca agt gta gtc att gtg ttt cat aat gaa gct tgg        384
Glu Leu Pro Asn Thr Ser Val Val Ile Val Phe His Asn Glu Ala Trp           
        115                 120                 125                       

agc act ctc ctt aga act gtt tac agt gtg ata aat cgt tcc cca cac        432
Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Ile Asn Arg Ser Pro His           
    130                 135                 140                           

tat cta ctc tca gag gtc atc ttg gta gat gat gcc agt gaa aga gat        480
Tyr Leu Leu Ser Glu Val Ile Leu Val Asp Asp Ala Ser Glu Arg Asp           
145                 150                 155                 160           

ttt ctc aag ttg aca tta gag aat tac gtg aaa aat tta gaa gtg cca        528
Phe Leu Lys Leu Thr Leu Glu Asn Tyr Val Lys Asn Leu Glu Val Pro           
                165                 170                 175               

gta aaa att att agg atg gaa gaa cgc tct ggg tta ata cgt gcc cgt        576
Val Lys Ile Ile Arg Met Glu Glu Arg Ser Gly Leu Ile Arg Ala Arg           
            180                 185                 190                   

ctt cga gga gca gct gct tca aaa ggg cag gtc ata act ttt ctt gat        624
Leu Arg Gly Ala Ala Ala Ser Lys Gly Gln Val Ile Thr Phe Leu Asp           
        195                 200                 205                       

gca cac tgt gaa tgc acg tta gga tgg ctg gag cct ttg ctg gca aga        672
Ala His Cys Glu Cys Thr Leu Gly Trp Leu Glu Pro Leu Leu Ala Arg           
    210                 215                 220                           

ata aag gaa gac agg aaa acg gtt gtc tgc cct atc att gat gtg att        720
Ile Lys Glu Asp Arg Lys Thr Val Val Cys Pro Ile Ile Asp Val Ile           
225                 230                 235                 240           

agt gat gat act ttt gaa tat atg gct ggg tca gac atg act tat ggg        768
Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr Gly           
                245                 250                 255               

ggt ttt aac tgg aaa ctg aat ttc cgc tgg tat cct gtt ccc caa aga        816
Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln Arg           
            260                 265                 270                   

gaa atg gac agg agg aaa gga gac aga aca tta cct gtc agg acc cct        864
Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Thr Pro           
        275                 280                 285                       

act atg gct ggt ggc cta ttt tct att gac aga aac tac ttt gaa gag        912
Thr Met Ala Gly Gly Leu Phe Ser Ile Asp Arg Asn Tyr Phe Glu Glu           
    290                 295                 300                           

ata gga act tac gat gca gga atg gat atc tgg ggt gga gag aat ctt        960
Ile Gly Thr Tyr Asp Ala Gly Met Asp Ile Trp Gly Gly Glu Asn Leu           
305                 310                 315                 320           

gaa atg tct ttt agg att tgg caa tgt gga ggc tcc ttg gag att gtt       1008
Glu Met Ser Phe Arg Ile Trp Gln Cys Gly Gly Ser Leu Glu Ile Val           
                325                 330                 335               

act tgc tcc cat gtt ggt cat gtt ttt cgg aag gca act cca tac act       1056
Thr Cys Ser His Val Gly His Val Phe Arg Lys Ala Thr Pro Tyr Thr           
            340                 345                 350                   

ttt cct ggt ggc act ggt cat gtc atc aac aag aac aac agg aga ctg       1104
Phe Pro Gly Gly Thr Gly His Val Ile Asn Lys Asn Asn Arg Arg Leu           
        355                 360                 365                       

gca gaa gtt tgg atg gat gaa ttt aaa gat ttc ttc tac atc ata tcc       1152
Ala Glu Val Trp Met Asp Glu Phe Lys Asp Phe Phe Tyr Ile Ile Ser           
    370                 375                 380                           

cca ggt gtt gtc aaa gtg gat tat gga gat gtg tca gtc aga aaa aca       1200
Pro Gly Val Val Lys Val Asp Tyr Gly Asp Val Ser Val Arg Lys Thr           
385                 390                 395                 400           

cta aga gaa aat ctg aag tgt aag ccc ttt tct tgg tac cta gaa aac       1248
Leu Arg Glu Asn Leu Lys Cys Lys Pro Phe Ser Trp Tyr Leu Glu Asn           
                405                 410                 415               

atc tat ccg gac tcc cag atc cca aga cgt tat tac tca ctt ggt gag       1296
Ile Tyr Pro Asp Ser Gln Ile Pro Arg Arg Tyr Tyr Ser Leu Gly Glu           
            420                 425                 430                   

ata aga aat gtt gaa acc aat cag tgt tta gac aac atg ggc cgc aag       1344
Ile Arg Asn Val Glu Thr Asn Gln Cys Leu Asp Asn Met Gly Arg Lys           
        435                 440                 445                       

gaa aat gaa aaa gtg ggt ata ttc aac tgt cat ggt atg gga gga aat       1392
Glu Asn Glu Lys Val Gly Ile Phe Asn Cys His Gly Met Gly Gly Asn           
    450                 455                 460                           

cag gta ttt tct tac act gct gac aaa gaa atc cga acc gat gac ttg       1440
Gln Val Phe Ser Tyr Thr Ala Asp Lys Glu Ile Arg Thr Asp Asp Leu           
465                 470                 475                 480           

tgc ttg gat gtt tct aga ctc aat gga cct gta atc atg tta aaa tgc       1488
Cys Leu Asp Val Ser Arg Leu Asn Gly Pro Val Ile Met Leu Lys Cys           
                485                 490                 495               

cac cat atg aga gga aat cag tta tgg gaa tat gat gct gag acc cac       1536
His His Met Arg Gly Asn Gln Leu Trp Glu Tyr Asp Ala Glu Thr His           
            500                 505                 510                   

act ctt ctt cat ata atc acc cag tct tgt ctc tca gtg aac aaa gta       1584
Thr Leu Leu His Ile Ile Thr Gln Ser Cys Leu Ser Val Asn Lys Val           
        515                 520                 525                       

gct gat ggc tcc cag cat cct act gtg gaa acc tgt aat gat agc act       1632
Ala Asp Gly Ser Gln His Pro Thr Val Glu Thr Cys Asn Asp Ser Thr           
    530                 535                 540                           

ttg caa aaa tgg cta cta aga aac tat aca aga atg gaa att ttt aga       1680
Leu Gln Lys Trp Leu Leu Arg Asn Tyr Thr Arg Met Glu Ile Phe Arg           
545                 550                 555                 560           

aat att ttt ggg aat tct act gat tac att ctc taa tga tttttggaga        1729
Asn Ile Phe Gly Asn Ser Thr Asp Tyr Ile Leu                               
                565                 570                                   

gactcacgtt gcgacatgtt aacagtaacc aatgtctcga tgaaccttct gaagaagaca     1789

aaatggtgcc tacaatgcag gactgtagtg gaagcagatc ccaacagtgg ctgctaagga     1849

acatgacctt gggcacatga                                                 1869


<210>  8
<211>  571
<212>  PRT
<213>  Homo sapiens (GalNAc-T13DelEx10B)

<400>  8

Met Arg Arg Phe Val Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Met 
1               5                   10                  15      


Trp Val Leu Val Asp Val Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn 
            20                  25                  30          


Lys Cys Asp Asp Lys Lys Glu Arg Ser Leu Leu Pro Ala Leu Arg Ala 
        35                  40                  45              


Val Ile Ser Arg Asn Gln Glu Gly Pro Gly Glu Met Gly Lys Ala Val 
    50                  55                  60                  


Leu Ile Pro Lys Asp Asp Gln Glu Lys Met Lys Glu Leu Phe Lys Ile 
65                  70                  75                  80  


Asn Gln Phe Asn Leu Met Ala Ser Asp Leu Ile Ala Leu Asn Arg Ser 
                85                  90                  95      


Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro Asp 
            100                 105                 110         


Glu Leu Pro Asn Thr Ser Val Val Ile Val Phe His Asn Glu Ala Trp 
        115                 120                 125             


Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Ile Asn Arg Ser Pro His 
    130                 135                 140                 


Tyr Leu Leu Ser Glu Val Ile Leu Val Asp Asp Ala Ser Glu Arg Asp 
145                 150                 155                 160 


Phe Leu Lys Leu Thr Leu Glu Asn Tyr Val Lys Asn Leu Glu Val Pro 
                165                 170                 175     


Val Lys Ile Ile Arg Met Glu Glu Arg Ser Gly Leu Ile Arg Ala Arg 
            180                 185                 190         


Leu Arg Gly Ala Ala Ala Ser Lys Gly Gln Val Ile Thr Phe Leu Asp 
        195                 200                 205             


Ala His Cys Glu Cys Thr Leu Gly Trp Leu Glu Pro Leu Leu Ala Arg 
    210                 215                 220                 


Ile Lys Glu Asp Arg Lys Thr Val Val Cys Pro Ile Ile Asp Val Ile 
225                 230                 235                 240 


Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr Gly 
                245                 250                 255     


Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln Arg 
            260                 265                 270         


Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Thr Pro 
        275                 280                 285             


Thr Met Ala Gly Gly Leu Phe Ser Ile Asp Arg Asn Tyr Phe Glu Glu 
    290                 295                 300                 


Ile Gly Thr Tyr Asp Ala Gly Met Asp Ile Trp Gly Gly Glu Asn Leu 
305                 310                 315                 320 


Glu Met Ser Phe Arg Ile Trp Gln Cys Gly Gly Ser Leu Glu Ile Val 
                325                 330                 335     


Thr Cys Ser His Val Gly His Val Phe Arg Lys Ala Thr Pro Tyr Thr 
            340                 345                 350         


Phe Pro Gly Gly Thr Gly His Val Ile Asn Lys Asn Asn Arg Arg Leu 
        355                 360                 365             


Ala Glu Val Trp Met Asp Glu Phe Lys Asp Phe Phe Tyr Ile Ile Ser 
    370                 375                 380                 


Pro Gly Val Val Lys Val Asp Tyr Gly Asp Val Ser Val Arg Lys Thr 
385                 390                 395                 400 


Leu Arg Glu Asn Leu Lys Cys Lys Pro Phe Ser Trp Tyr Leu Glu Asn 
                405                 410                 415     


Ile Tyr Pro Asp Ser Gln Ile Pro Arg Arg Tyr Tyr Ser Leu Gly Glu 
            420                 425                 430         


Ile Arg Asn Val Glu Thr Asn Gln Cys Leu Asp Asn Met Gly Arg Lys 
        435                 440                 445             


Glu Asn Glu Lys Val Gly Ile Phe Asn Cys His Gly Met Gly Gly Asn 
    450                 455                 460                 


Gln Val Phe Ser Tyr Thr Ala Asp Lys Glu Ile Arg Thr Asp Asp Leu 
465                 470                 475                 480 


Cys Leu Asp Val Ser Arg Leu Asn Gly Pro Val Ile Met Leu Lys Cys 
                485                 490                 495     


His His Met Arg Gly Asn Gln Leu Trp Glu Tyr Asp Ala Glu Thr His 
            500                 505                 510         


Thr Leu Leu His Ile Ile Thr Gln Ser Cys Leu Ser Val Asn Lys Val 
        515                 520                 525             


Ala Asp Gly Ser Gln His Pro Thr Val Glu Thr Cys Asn Asp Ser Thr 
    530                 535                 540                 


Leu Gln Lys Trp Leu Leu Arg Asn Tyr Thr Arg Met Glu Ile Phe Arg 
545                 550                 555                 560 


Asn Ile Phe Gly Asn Ser Thr Asp Tyr Ile Leu 
                565                 570     


<210>  9
<211>  657
<212>  DNA
<213>  Homo sapiens (GalNAc-T13DelEx2-Ex7)


<220>
<221>  CDS
<222>  (1)..(657)

<400>  9
atg agg aga ttt gtc tac tgc aag gtg gtt cta gcc act tcg ctg atg         48
Met Arg Arg Phe Val Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Met           
1               5                   10                  15                

tgg gtt ctt gtt gat gtc ttc tta ctg ctg tac ttc agt gaa tgt aac         96
Trp Val Leu Val Asp Val Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn           
            20                  25                  30                    

aaa tgt gat gac aag aag gag aga tct ctg ctg cct gca ttg agg ggt        144
Lys Cys Asp Asp Lys Lys Glu Arg Ser Leu Leu Pro Ala Leu Arg Gly           
        35                  40                  45                        

gtt gtc aaa gtg gat tat gga gat gtg tca gtc aga aaa aca cta aga        192
Val Val Lys Val Asp Tyr Gly Asp Val Ser Val Arg Lys Thr Leu Arg           
    50                  55                  60                            

gaa aat ctg aag tgt aag ccc ttt tct tgg tac cta gaa aac atc tat        240
Glu Asn Leu Lys Cys Lys Pro Phe Ser Trp Tyr Leu Glu Asn Ile Tyr           
65                  70                  75                  80            

ccg gac tcc cag atc cca aga cgt tat tac tca ctt ggt gag ata aga        288
Pro Asp Ser Gln Ile Pro Arg Arg Tyr Tyr Ser Leu Gly Glu Ile Arg           
                85                  90                  95                

aat gtt gaa acc aat cag tgt tta gac aac atg ggc cgc aag gaa aat        336
Asn Val Glu Thr Asn Gln Cys Leu Asp Asn Met Gly Arg Lys Glu Asn           
            100                 105                 110                   

gaa aaa gtg ggt ata ttc aac tgt cat ggt atg gga gga aat cag gta        384
Glu Lys Val Gly Ile Phe Asn Cys His Gly Met Gly Gly Asn Gln Val           
        115                 120                 125                       

ttt tct tac act gct gac aaa gaa atc cga acc gat gac ttg tgc ttg        432
Phe Ser Tyr Thr Ala Asp Lys Glu Ile Arg Thr Asp Asp Leu Cys Leu           
    130                 135                 140                           

gat gtt tct aga ctc aat gga cct gta atc atg tta aaa tgc cac cat        480
Asp Val Ser Arg Leu Asn Gly Pro Val Ile Met Leu Lys Cys His His           
145                 150                 155                 160           

atg aga gga aat cag tta tgg gaa tat gat gct gag aga ctc acg ttg        528
Met Arg Gly Asn Gln Leu Trp Glu Tyr Asp Ala Glu Arg Leu Thr Leu           
                165                 170                 175               

cga cat gtt aac agt aac caa tgt ctc gat gaa cct tct gaa gaa gac        576
Arg His Val Asn Ser Asn Gln Cys Leu Asp Glu Pro Ser Glu Glu Asp           
            180                 185                 190                   

aaa atg gtg cct aca atg cag gac tgt agt gga agc aga tcc caa cag        624
Lys Met Val Pro Thr Met Gln Asp Cys Ser Gly Ser Arg Ser Gln Gln           
        195                 200                 205                       

tgg ctg cta agg aac atg acc ttg ggc aca tga                            657
Trp Leu Leu Arg Asn Met Thr Leu Gly Thr                                   
    210                 215                                               


<210>  10
<211>  218
<212>  PRT
<213>  Homo sapiens (GalNAc-T13DelEx2-Ex7)

<400>  10

Met Arg Arg Phe Val Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Met 
1               5                   10                  15      


Trp Val Leu Val Asp Val Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn 
            20                  25                  30          


Lys Cys Asp Asp Lys Lys Glu Arg Ser Leu Leu Pro Ala Leu Arg Gly 
        35                  40                  45              


Val Val Lys Val Asp Tyr Gly Asp Val Ser Val Arg Lys Thr Leu Arg 
    50                  55                  60                  


Glu Asn Leu Lys Cys Lys Pro Phe Ser Trp Tyr Leu Glu Asn Ile Tyr 
65                  70                  75                  80  


Pro Asp Ser Gln Ile Pro Arg Arg Tyr Tyr Ser Leu Gly Glu Ile Arg 
                85                  90                  95      


Asn Val Glu Thr Asn Gln Cys Leu Asp Asn Met Gly Arg Lys Glu Asn 
            100                 105                 110         


Glu Lys Val Gly Ile Phe Asn Cys His Gly Met Gly Gly Asn Gln Val 
        115                 120                 125             


Phe Ser Tyr Thr Ala Asp Lys Glu Ile Arg Thr Asp Asp Leu Cys Leu 
    130                 135                 140                 


Asp Val Ser Arg Leu Asn Gly Pro Val Ile Met Leu Lys Cys His His 
145                 150                 155                 160 


Met Arg Gly Asn Gln Leu Trp Glu Tyr Asp Ala Glu Arg Leu Thr Leu 
                165                 170                 175     


Arg His Val Asn Ser Asn Gln Cys Leu Asp Glu Pro Ser Glu Glu Asp 
            180                 185                 190         


Lys Met Val Pro Thr Met Gln Asp Cys Ser Gly Ser Arg Ser Gln Gln 
        195                 200                 205             


Trp Leu Leu Arg Asn Met Thr Leu Gly Thr 
    210                 215             


<210>  11
<211>  1554
<212>  DNA
<213>  Homo sapiens (GalNAc-T13DelEx6)


<220>
<221>  CDS
<222>  (1)..(1083)

<400>  11
atg agg aga ttt gtc tac tgc aag gtg gtt cta gcc act tcg ctg atg         48
Met Arg Arg Phe Val Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Met           
1               5                   10                  15                

tgg gtt ctt gtt gat gtc ttc tta ctg ctg tac ttc agt gaa tgt aac         96
Trp Val Leu Val Asp Val Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn           
            20                  25                  30                    

aaa tgt gat gac aag aag gag aga tct ctg ctg cct gca ttg agg gct        144
Lys Cys Asp Asp Lys Lys Glu Arg Ser Leu Leu Pro Ala Leu Arg Ala           
        35                  40                  45                        

gtt att tca aga aac caa gaa ggg cca gga gaa atg gga aaa gct gtg        192
Val Ile Ser Arg Asn Gln Glu Gly Pro Gly Glu Met Gly Lys Ala Val           
    50                  55                  60                            

ttg att cct aaa gat gac cag gag aaa atg aaa gag ctg ttt aaa atc        240
Leu Ile Pro Lys Asp Asp Gln Glu Lys Met Lys Glu Leu Phe Lys Ile           
65                  70                  75                  80            

aat cag ttt aac ctt atg gcc agt gat ttg att gcc ctt aat aga agt        288
Asn Gln Phe Asn Leu Met Ala Ser Asp Leu Ile Ala Leu Asn Arg Ser           
                85                  90                  95                

ctg cca gat gta aga tta gaa gga tgt aag aca aaa gtc tac cct gat        336
Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro Asp           
            100                 105                 110                   

gaa ctt cca aac aca agt gta gtc att gtg ttt cat aat gaa gct tgg        384
Glu Leu Pro Asn Thr Ser Val Val Ile Val Phe His Asn Glu Ala Trp           
        115                 120                 125                       

agc act ctc ctt aga act gtt tac agt gtg ata aat cgt tcc cca cac        432
Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Ile Asn Arg Ser Pro His           
    130                 135                 140                           

tat cta ctc tca gag gtc atc ttg gta gat gat gcc agt gaa aga gat        480
Tyr Leu Leu Ser Glu Val Ile Leu Val Asp Asp Ala Ser Glu Arg Asp           
145                 150                 155                 160           

ttt ctc aag ttg aca tta gag aat tac gtg aaa aat tta gaa gtg cca        528
Phe Leu Lys Leu Thr Leu Glu Asn Tyr Val Lys Asn Leu Glu Val Pro           
                165                 170                 175               

gta aaa att att agg atg gaa gaa cgc tct ggg tta ata cgt gcc cgt        576
Val Lys Ile Ile Arg Met Glu Glu Arg Ser Gly Leu Ile Arg Ala Arg           
            180                 185                 190                   

ctt cga gga gca gct gct tca aaa ggg cag gtc ata act ttt ctt gat        624
Leu Arg Gly Ala Ala Ala Ser Lys Gly Gln Val Ile Thr Phe Leu Asp           
        195                 200                 205                       

gca cac tgt gaa tgc acg tta gga tgg ctg gag cct ttg ctg gca aga        672
Ala His Cys Glu Cys Thr Leu Gly Trp Leu Glu Pro Leu Leu Ala Arg           
    210                 215                 220                           

ata aag gaa gac agg aaa acg gtt gtc tgc cct atc att gat gtg att        720
Ile Lys Glu Asp Arg Lys Thr Val Val Cys Pro Ile Ile Asp Val Ile           
225                 230                 235                 240           

agt gat gat act ttt gaa tat atg gct ggg tca gac atg act tat ggg        768
Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr Gly           
                245                 250                 255               

ggt ttt aac tgg aaa ctg aat ttc cgc tgg tat cct gtt ccc caa aga        816
Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln Arg           
            260                 265                 270                   

gaa atg gac agg agg aaa gga gac aga aca tta cct gtc aga ttt ggc        864
Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Phe Gly           
        275                 280                 285                       

aat gtg gag gct cct tgg aga ttg tta ctt gct ccc atg ttg gtc atg        912
Asn Val Glu Ala Pro Trp Arg Leu Leu Leu Ala Pro Met Leu Val Met           
    290                 295                 300                           

ttt ttc gga agg caa ctc cat aca ctt ttc ctg gtg gca ctg gtc atg        960
Phe Phe Gly Arg Gln Leu His Thr Leu Phe Leu Val Ala Leu Val Met           
305                 310                 315                 320           

tca tca aca aga aca aca gga gac tgg cag aag ttt gga tgg atg aat       1008
Ser Ser Thr Arg Thr Thr Gly Asp Trp Gln Lys Phe Gly Trp Met Asn           
                325                 330                 335               

tta aag att tct tct aca tca tat ccc cag gtg ttg tca aag tgg att       1056
Leu Lys Ile Ser Ser Thr Ser Tyr Pro Gln Val Leu Ser Lys Trp Ile           
            340                 345                 350                   

atg gag atg tgt cag tca gaa aaa cac taagagaaaa tctgaagtgt             1103
Met Glu Met Cys Gln Ser Glu Lys His                                       
        355                 360                                           

aagccctttt cttggtacct agaaaacatc tatccgghac tcccagatcc caagacgtta     1163

ttactcactt ggtgagataa gaaatgttga aaccaatcag tgtttagaca acatgggccg     1223

caaggaaaat gaaaaagtgg gtatattcaa ctgtcatggt atgggaggaa atcaggtatt     1283

ttcttacact gctgacaaag aaatccgaac cgatgacttg tgcttggatg tttctagact     1343

caatggacct gtaatcatgt taaaatgcca ccatatgaga ggaaatcagt tatgggaata     1403

tgatgctgag agactcacgt tgcgacatgt taacagtaac caatgtctcg atgaaccttc     1463

tgaagaagac aaaatggtgc ctacaatgca ggactgtagt ggaagcagat cccaacagtg     1523

gctgctaagg aacatgacct tgggcacatg a                                    1554


<210>  12
<211>  361
<212>  PRT
<213>  Homo sapiens (GalNAc-T13DelEx6)

<400>  12

Met Arg Arg Phe Val Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Met 
1               5                   10                  15      


Trp Val Leu Val Asp Val Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn 
            20                  25                  30          


Lys Cys Asp Asp Lys Lys Glu Arg Ser Leu Leu Pro Ala Leu Arg Ala 
        35                  40                  45              


Val Ile Ser Arg Asn Gln Glu Gly Pro Gly Glu Met Gly Lys Ala Val 
    50                  55                  60                  


Leu Ile Pro Lys Asp Asp Gln Glu Lys Met Lys Glu Leu Phe Lys Ile 
65                  70                  75                  80  


Asn Gln Phe Asn Leu Met Ala Ser Asp Leu Ile Ala Leu Asn Arg Ser 
                85                  90                  95      


Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro Asp 
            100                 105                 110         


Glu Leu Pro Asn Thr Ser Val Val Ile Val Phe His Asn Glu Ala Trp 
        115                 120                 125             


Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Ile Asn Arg Ser Pro His 
    130                 135                 140                 


Tyr Leu Leu Ser Glu Val Ile Leu Val Asp Asp Ala Ser Glu Arg Asp 
145                 150                 155                 160 


Phe Leu Lys Leu Thr Leu Glu Asn Tyr Val Lys Asn Leu Glu Val Pro 
                165                 170                 175     


Val Lys Ile Ile Arg Met Glu Glu Arg Ser Gly Leu Ile Arg Ala Arg 
            180                 185                 190         


Leu Arg Gly Ala Ala Ala Ser Lys Gly Gln Val Ile Thr Phe Leu Asp 
        195                 200                 205             


Ala His Cys Glu Cys Thr Leu Gly Trp Leu Glu Pro Leu Leu Ala Arg 
    210                 215                 220                 


Ile Lys Glu Asp Arg Lys Thr Val Val Cys Pro Ile Ile Asp Val Ile 
225                 230                 235                 240 


Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr Gly 
                245                 250                 255     


Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln Arg 
            260                 265                 270         


Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Phe Gly 
        275                 280                 285             


Asn Val Glu Ala Pro Trp Arg Leu Leu Leu Ala Pro Met Leu Val Met 
    290                 295                 300                 


Phe Phe Gly Arg Gln Leu His Thr Leu Phe Leu Val Ala Leu Val Met 
305                 310                 315                 320 


Ser Ser Thr Arg Thr Thr Gly Asp Trp Gln Lys Phe Gly Trp Met Asn 
                325                 330                 335     


Leu Lys Ile Ser Ser Thr Ser Tyr Pro Gln Val Leu Ser Lys Trp Ile 
            340                 345                 350         


Met Glu Met Cys Gln Ser Glu Lys His 
        355                 360     


<210>  13
<211>  1531
<212>  DNA
<213>  GalNAc-T13DelEx8


<220>
<221>  CDS
<222>  (1)..(1170)

<400>  13
atg agg aga ttt gtc tac tgc aag gtg gtt cta gcc act tcg ctg atg         48
Met Arg Arg Phe Val Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Met           
1               5                   10                  15                

tgg gtt ctt gtt gat gtc ttc tta ctg ctg tac ttc agt gaa tgt aac         96
Trp Val Leu Val Asp Val Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn           
            20                  25                  30                    

aaa tgt gat gac aag aag gag aga tct ctg ctg cct gca ttg agg gct        144
Lys Cys Asp Asp Lys Lys Glu Arg Ser Leu Leu Pro Ala Leu Arg Ala           
        35                  40                  45                        

gtt att tca aga aac caa gaa ggg cca gga gaa atg gga aaa gct gtg        192
Val Ile Ser Arg Asn Gln Glu Gly Pro Gly Glu Met Gly Lys Ala Val           
    50                  55                  60                            

ttg att cct aaa gat gac cag gag aaa atg aaa gag ctg ttt aaa atc        240
Leu Ile Pro Lys Asp Asp Gln Glu Lys Met Lys Glu Leu Phe Lys Ile           
65                  70                  75                  80            

aat cag ttt aac ctt atg gcc agt gat ttg att gcc ctt aat aga agt        288
Asn Gln Phe Asn Leu Met Ala Ser Asp Leu Ile Ala Leu Asn Arg Ser           
                85                  90                  95                

ctg cca gat gta aga tta gaa gga tgt aag aca aaa gtc tac cct gat        336
Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro Asp           
            100                 105                 110                   

gaa ctt cca aac aca agt gta gtc att gtg ttt cat aat gaa gct tgg        384
Glu Leu Pro Asn Thr Ser Val Val Ile Val Phe His Asn Glu Ala Trp           
        115                 120                 125                       

agc act ctc ctt aga act gtt tac agt gtg ata aat cgt tcc cca cac        432
Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Ile Asn Arg Ser Pro His           
    130                 135                 140                           

tat cta ctc tca gag gtc atc ttg gta gat gat gcc agt gaa aga gat        480
Tyr Leu Leu Ser Glu Val Ile Leu Val Asp Asp Ala Ser Glu Arg Asp           
145                 150                 155                 160           

ttt ctc aag ttg aca tta gag aat tac gtg aaa aat tta gaa gtg cca        528
Phe Leu Lys Leu Thr Leu Glu Asn Tyr Val Lys Asn Leu Glu Val Pro           
                165                 170                 175               

gta aaa att att agg atg gaa gaa cgc tct ggg tta ata cgt gcc cgt        576
Val Lys Ile Ile Arg Met Glu Glu Arg Ser Gly Leu Ile Arg Ala Arg           
            180                 185                 190                   

ctt cga gga gca gct gct tca aaa ggg cag gtc ata act ttt ctt gat        624
Leu Arg Gly Ala Ala Ala Ser Lys Gly Gln Val Ile Thr Phe Leu Asp           
        195                 200                 205                       

gca cac tgt gaa tgc acg tta gga tgg ctg gag cct ttg ctg gca aga        672
Ala His Cys Glu Cys Thr Leu Gly Trp Leu Glu Pro Leu Leu Ala Arg           
    210                 215                 220                           

ata aag gaa gac agg aaa acg gtt gtc tgc cct atc att gat gtg att        720
Ile Lys Glu Asp Arg Lys Thr Val Val Cys Pro Ile Ile Asp Val Ile           
225                 230                 235                 240           

agt gat gat act ttt gaa tat atg gct ggg tca gac atg act tat ggg        768
Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr Gly           
                245                 250                 255               

ggt ttt aac tgg aaa ctg aat ttc cgc tgg tat cct gtt ccc caa aga        816
Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln Arg           
            260                 265                 270                   

gaa atg gac agg agg aaa gga gac aga aca tta cct gtc agg acc cct        864
Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Thr Pro           
        275                 280                 285                       

act atg gct ggt ggc cta ttt tct att gac aga aac tac ttt gaa gag        912
Thr Met Ala Gly Gly Leu Phe Ser Ile Asp Arg Asn Tyr Phe Glu Glu           
    290                 295                 300                           

ata gga act tac gat gca gga atg gat atc tgg ggt gga gag aat ctt        960
Ile Gly Thr Tyr Asp Ala Gly Met Asp Ile Trp Gly Gly Glu Asn Leu           
305                 310                 315                 320           

gaa atg tct ttt agg att tgg caa tgt gga ggc tcc ttg gag att gtt       1008
Glu Met Ser Phe Arg Ile Trp Gln Cys Gly Gly Ser Leu Glu Ile Val           
                325                 330                 335               

act tgc tcc cat gtt ggt cat gtt ttt cgg aag gca act cca tac act       1056
Thr Cys Ser His Val Gly His Val Phe Arg Lys Ala Thr Pro Tyr Thr           
            340                 345                 350                   

ttt cct ggt ggc act ggt cat gtc atc aac aag aac aac agg aga ctg       1104
Phe Pro Gly Gly Thr Gly His Val Ile Asn Lys Asn Asn Arg Arg Leu           
        355                 360                 365                       

gca gaa gtt tgg atg gat gaa ttt aaa gat ttc ttc tac atc ata tcc       1152
Ala Glu Val Trp Met Asp Glu Phe Lys Asp Phe Phe Tyr Ile Ile Ser           
    370                 375                 380                           

cca gat aag aaa tgt tga aaccaatcag tgtttagaca acatgggccg              1200
Pro Asp Lys Lys Cys                                                       
385                                                                       

caaggaaaat gaaaaagtgg gtatattcaa ctgtcatggt atgggaggaa atcaggtatt     1260

ttcttacact gctgacaaag aaatccgaac cgatgacttg tgcttggatg tttctagact     1320

caatggacct gtaatcatgt taaaatgcca ccatatgaga ggaaatcagt tatgggaata     1380

tgatgctgag agactcacgt tgcgacatgt taacagtaac caatgtctcg atgaaccttc     1440

tgaagaagac aaaatggtgc ctacaatgca ggactgtagt ggaagcagat cccaacagtg     1500

gctgctaagg aacatgacct tgggcacatg a                                    1531


<210>  14
<211>  389
<212>  PRT
<213>  GalNAc-T13DelEx8

<400>  14

Met Arg Arg Phe Val Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Met 
1               5                   10                  15      


Trp Val Leu Val Asp Val Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn 
            20                  25                  30          


Lys Cys Asp Asp Lys Lys Glu Arg Ser Leu Leu Pro Ala Leu Arg Ala 
        35                  40                  45              


Val Ile Ser Arg Asn Gln Glu Gly Pro Gly Glu Met Gly Lys Ala Val 
    50                  55                  60                  


Leu Ile Pro Lys Asp Asp Gln Glu Lys Met Lys Glu Leu Phe Lys Ile 
65                  70                  75                  80  


Asn Gln Phe Asn Leu Met Ala Ser Asp Leu Ile Ala Leu Asn Arg Ser 
                85                  90                  95      


Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro Asp 
            100                 105                 110         


Glu Leu Pro Asn Thr Ser Val Val Ile Val Phe His Asn Glu Ala Trp 
        115                 120                 125             


Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Ile Asn Arg Ser Pro His 
    130                 135                 140                 


Tyr Leu Leu Ser Glu Val Ile Leu Val Asp Asp Ala Ser Glu Arg Asp 
145                 150                 155                 160 


Phe Leu Lys Leu Thr Leu Glu Asn Tyr Val Lys Asn Leu Glu Val Pro 
                165                 170                 175     


Val Lys Ile Ile Arg Met Glu Glu Arg Ser Gly Leu Ile Arg Ala Arg 
            180                 185                 190         


Leu Arg Gly Ala Ala Ala Ser Lys Gly Gln Val Ile Thr Phe Leu Asp 
        195                 200                 205             


Ala His Cys Glu Cys Thr Leu Gly Trp Leu Glu Pro Leu Leu Ala Arg 
    210                 215                 220                 


Ile Lys Glu Asp Arg Lys Thr Val Val Cys Pro Ile Ile Asp Val Ile 
225                 230                 235                 240 


Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr Gly 
                245                 250                 255     


Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln Arg 
            260                 265                 270         


Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Thr Pro 
        275                 280                 285             


Thr Met Ala Gly Gly Leu Phe Ser Ile Asp Arg Asn Tyr Phe Glu Glu 
    290                 295                 300                 


Ile Gly Thr Tyr Asp Ala Gly Met Asp Ile Trp Gly Gly Glu Asn Leu 
305                 310                 315                 320 


Glu Met Ser Phe Arg Ile Trp Gln Cys Gly Gly Ser Leu Glu Ile Val 
                325                 330                 335     


Thr Cys Ser His Val Gly His Val Phe Arg Lys Ala Thr Pro Tyr Thr 
            340                 345                 350         


Phe Pro Gly Gly Thr Gly His Val Ile Asn Lys Asn Asn Arg Arg Leu 
        355                 360                 365             


Ala Glu Val Trp Met Asp Glu Phe Lys Asp Phe Phe Tyr Ile Ile Ser 
    370                 375                 380                 


Pro Asp Lys Lys Cys 
385                 


<210>  15
<211>  1413
<212>  DNA
<213>  Homo sapiens (GalNAc-T13DelEx6DelEx8)


<220>
<221>  CDS
<222>  (1)..(1413)

<400>  15
atg agg aga ttt gtc tac tgc aag gtg gtt cta gcc act tcg ctg atg         48
Met Arg Arg Phe Val Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Met           
1               5                   10                  15                

tgg gtt ctt gtt gat gtc ttc tta ctg ctg tac ttc agt gaa tgt aac         96
Trp Val Leu Val Asp Val Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn           
            20                  25                  30                    

aaa tgt gat gac aag aag gag aga tct ctg ctg cct gca ttg agg gct        144
Lys Cys Asp Asp Lys Lys Glu Arg Ser Leu Leu Pro Ala Leu Arg Ala           
        35                  40                  45                        

gtt att tca aga aac caa gaa ggg cca gga gaa atg gga aaa gct gtg        192
Val Ile Ser Arg Asn Gln Glu Gly Pro Gly Glu Met Gly Lys Ala Val           
    50                  55                  60                            

ttg att cct aaa gat gac cag gag aaa atg aaa gag ctg ttt aaa atc        240
Leu Ile Pro Lys Asp Asp Gln Glu Lys Met Lys Glu Leu Phe Lys Ile           
65                  70                  75                  80            

aat cag ttt aac ctt atg gcc agt gat ttg att gcc ctt aat aga agt        288
Asn Gln Phe Asn Leu Met Ala Ser Asp Leu Ile Ala Leu Asn Arg Ser           
                85                  90                  95                

ctg cca gat gta aga tta gaa gga tgt aag aca aaa gtc tac cct gat        336
Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro Asp           
            100                 105                 110                   

gaa ctt cca aac aca agt gta gtc att gtg ttt cat aat gaa gct tgg        384
Glu Leu Pro Asn Thr Ser Val Val Ile Val Phe His Asn Glu Ala Trp           
        115                 120                 125                       

agc act ctc ctt aga act gtt tac agt gtg ata aat cgt tcc cca cac        432
Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Ile Asn Arg Ser Pro His           
    130                 135                 140                           

tat cta ctc tca gag gtc atc ttg gta gat gat gcc agt gaa aga gat        480
Tyr Leu Leu Ser Glu Val Ile Leu Val Asp Asp Ala Ser Glu Arg Asp           
145                 150                 155                 160           

ttt ctc aag ttg aca tta gag aat tac gtg aaa aat tta gaa gtg cca        528
Phe Leu Lys Leu Thr Leu Glu Asn Tyr Val Lys Asn Leu Glu Val Pro           
                165                 170                 175               

gta aaa att att agg atg gaa gaa cgc tct ggg tta ata cgt gcc cgt        576
Val Lys Ile Ile Arg Met Glu Glu Arg Ser Gly Leu Ile Arg Ala Arg           
            180                 185                 190                   

ctt cga gga gca gct gct tca aaa ggg cag gtc ata act ttt ctt gat        624
Leu Arg Gly Ala Ala Ala Ser Lys Gly Gln Val Ile Thr Phe Leu Asp           
        195                 200                 205                       

gca cac tgt gaa tgc acg tta gga tgg ctg gag cct ttg ctg gca aga        672
Ala His Cys Glu Cys Thr Leu Gly Trp Leu Glu Pro Leu Leu Ala Arg           
    210                 215                 220                           

ata aag gaa gac agg aaa acg gtt gtc tgc cct atc att gat gtg att        720
Ile Lys Glu Asp Arg Lys Thr Val Val Cys Pro Ile Ile Asp Val Ile           
225                 230                 235                 240           

agt gat gat act ttt gaa tat atg gct ggg tca gac atg act tat ggg        768
Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr Gly           
                245                 250                 255               

ggt ttt aac tgg aaa ctg aat ttc cgc tgg tat cct gtt ccc caa aga        816
Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln Arg           
            260                 265                 270                   

gaa atg gac agg agg aaa gga gac aga aca tta cct gtc aga ttt ggc        864
Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Phe Gly           
        275                 280                 285                       

aat gtg gag gct cct tgg aga ttg tta ctt gct ccc atg ttg gtc atg        912
Asn Val Glu Ala Pro Trp Arg Leu Leu Leu Ala Pro Met Leu Val Met           
    290                 295                 300                           

ttt ttc gga agg caa ctc cat aca ctt ttc ctg gtg gca ctg gtc atg        960
Phe Phe Gly Arg Gln Leu His Thr Leu Phe Leu Val Ala Leu Val Met           
305                 310                 315                 320           

tca tca aca aga aca aca gga gac tgg cag aag ttt gga tgg atg aat       1008
Ser Ser Thr Arg Thr Thr Gly Asp Trp Gln Lys Phe Gly Trp Met Asn           
                325                 330                 335               

tta aag att tct tct aca tca tat ccc cag ata aga aat gtt gaa acc       1056
Leu Lys Ile Ser Ser Thr Ser Tyr Pro Gln Ile Arg Asn Val Glu Thr           
            340                 345                 350                   

aat cag tgt tta gac aac atg ggc cgc aag gaa aat gaa aaa gtg ggt       1104
Asn Gln Cys Leu Asp Asn Met Gly Arg Lys Glu Asn Glu Lys Val Gly           
        355                 360                 365                       

ata ttc aac tgt cat ggt atg gga gga aat cag gta ttt tct tac act       1152
Ile Phe Asn Cys His Gly Met Gly Gly Asn Gln Val Phe Ser Tyr Thr           
    370                 375                 380                           

gct gac aaa gaa atc cga acc gat gac ttg tgc ttg gat gtt tct aga       1200
Ala Asp Lys Glu Ile Arg Thr Asp Asp Leu Cys Leu Asp Val Ser Arg           
385                 390                 395                 400           

ctc aat gga cct gta atc atg tta aaa tgc cac cat atg aga gga aat       1248
Leu Asn Gly Pro Val Ile Met Leu Lys Cys His His Met Arg Gly Asn           
                405                 410                 415               

cag tta tgg gaa tat gat gct gag aga ctc acg ttg cga cat gtt aac       1296
Gln Leu Trp Glu Tyr Asp Ala Glu Arg Leu Thr Leu Arg His Val Asn           
            420                 425                 430                   

agt aac caa tgt ctc gat gaa cct tct gaa gaa gac aaa atg gtg cct       1344
Ser Asn Gln Cys Leu Asp Glu Pro Ser Glu Glu Asp Lys Met Val Pro           
        435                 440                 445                       

aca atg cag gac tgt agt gga agc aga tcc caa cag tgg ctg cta agg       1392
Thr Met Gln Asp Cys Ser Gly Ser Arg Ser Gln Gln Trp Leu Leu Arg           
    450                 455                 460                           

aac atg acc ttg ggc aca tga                                           1413
Asn Met Thr Leu Gly Thr                                                   
465                 470                                                   


<210>  16
<211>  470
<212>  PRT
<213>  Homo sapiens (GalNAc-T13DelEx6DelEx8)

<400>  16

Met Arg Arg Phe Val Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Met 
1               5                   10                  15      


Trp Val Leu Val Asp Val Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn 
            20                  25                  30          


Lys Cys Asp Asp Lys Lys Glu Arg Ser Leu Leu Pro Ala Leu Arg Ala 
        35                  40                  45              


Val Ile Ser Arg Asn Gln Glu Gly Pro Gly Glu Met Gly Lys Ala Val 
    50                  55                  60                  


Leu Ile Pro Lys Asp Asp Gln Glu Lys Met Lys Glu Leu Phe Lys Ile 
65                  70                  75                  80  


Asn Gln Phe Asn Leu Met Ala Ser Asp Leu Ile Ala Leu Asn Arg Ser 
                85                  90                  95      


Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro Asp 
            100                 105                 110         


Glu Leu Pro Asn Thr Ser Val Val Ile Val Phe His Asn Glu Ala Trp 
        115                 120                 125             


Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Ile Asn Arg Ser Pro His 
    130                 135                 140                 


Tyr Leu Leu Ser Glu Val Ile Leu Val Asp Asp Ala Ser Glu Arg Asp 
145                 150                 155                 160 


Phe Leu Lys Leu Thr Leu Glu Asn Tyr Val Lys Asn Leu Glu Val Pro 
                165                 170                 175     


Val Lys Ile Ile Arg Met Glu Glu Arg Ser Gly Leu Ile Arg Ala Arg 
            180                 185                 190         


Leu Arg Gly Ala Ala Ala Ser Lys Gly Gln Val Ile Thr Phe Leu Asp 
        195                 200                 205             


Ala His Cys Glu Cys Thr Leu Gly Trp Leu Glu Pro Leu Leu Ala Arg 
    210                 215                 220                 


Ile Lys Glu Asp Arg Lys Thr Val Val Cys Pro Ile Ile Asp Val Ile 
225                 230                 235                 240 


Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr Gly 
                245                 250                 255     


Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln Arg 
            260                 265                 270         


Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Phe Gly 
        275                 280                 285             


Asn Val Glu Ala Pro Trp Arg Leu Leu Leu Ala Pro Met Leu Val Met 
    290                 295                 300                 


Phe Phe Gly Arg Gln Leu His Thr Leu Phe Leu Val Ala Leu Val Met 
305                 310                 315                 320 


Ser Ser Thr Arg Thr Thr Gly Asp Trp Gln Lys Phe Gly Trp Met Asn 
                325                 330                 335     


Leu Lys Ile Ser Ser Thr Ser Tyr Pro Gln Ile Arg Asn Val Glu Thr 
            340                 345                 350         


Asn Gln Cys Leu Asp Asn Met Gly Arg Lys Glu Asn Glu Lys Val Gly 
        355                 360                 365             


Ile Phe Asn Cys His Gly Met Gly Gly Asn Gln Val Phe Ser Tyr Thr 
    370                 375                 380                 


Ala Asp Lys Glu Ile Arg Thr Asp Asp Leu Cys Leu Asp Val Ser Arg 
385                 390                 395                 400 


Leu Asn Gly Pro Val Ile Met Leu Lys Cys His His Met Arg Gly Asn 
                405                 410                 415     


Gln Leu Trp Glu Tyr Asp Ala Glu Arg Leu Thr Leu Arg His Val Asn 
            420                 425                 430         


Ser Asn Gln Cys Leu Asp Glu Pro Ser Glu Glu Asp Lys Met Val Pro 
        435                 440                 445             


Thr Met Gln Asp Cys Ser Gly Ser Arg Ser Gln Gln Trp Leu Leu Arg 
    450                 455                 460                 


Asn Met Thr Leu Gly Thr 
465                 470 


<210>  17
<211>  1572
<212>  DNA
<213>  Homo sapiens (GalNAc-T13DelEx6DelEx8Del39bpEx9DelEx10B)


<220>
<221>  CDS
<222>  (1)..(1419)

<400>  17
atg agg aga ttt gtc tac tgc aag gtg gtt cta gcc act tcg ctg atg         48
Met Arg Arg Phe Val Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Met           
1               5                   10                  15                

tgg gtt ctt gtt gat gtc ttc tta ctg ctg tac ttc agt gaa tgt aac         96
Trp Val Leu Val Asp Val Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn           
            20                  25                  30                    

aaa tgt gat gac aag aag gag aga tct ctg ctg cct gca ttg agg gct        144
Lys Cys Asp Asp Lys Lys Glu Arg Ser Leu Leu Pro Ala Leu Arg Ala           
        35                  40                  45                        

gtt att tca aga aac caa gaa ggg cca gga gaa atg gga aaa gct gtg        192
Val Ile Ser Arg Asn Gln Glu Gly Pro Gly Glu Met Gly Lys Ala Val           
    50                  55                  60                            

ttg att cct aaa gat gac cag gag aaa atg aaa gag ctg ttt aaa atc        240
Leu Ile Pro Lys Asp Asp Gln Glu Lys Met Lys Glu Leu Phe Lys Ile           
65                  70                  75                  80            

aat cag ttt aac ctt atg gcc agt gat ttg att gcc ctt aat aga agt        288
Asn Gln Phe Asn Leu Met Ala Ser Asp Leu Ile Ala Leu Asn Arg Ser           
                85                  90                  95                

ctg cca gat gta aga tta gaa gga tgt aag aca aaa gtc tac cct gat        336
Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro Asp           
            100                 105                 110                   

gaa ctt cca aac aca agt gta gtc att gtg ttt cat aat gaa gct tgg        384
Glu Leu Pro Asn Thr Ser Val Val Ile Val Phe His Asn Glu Ala Trp           
        115                 120                 125                       

agc act ctc ctt aga act gtt tac agt gtg ata aat cgt tcc cca cac        432
Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Ile Asn Arg Ser Pro His           
    130                 135                 140                           

tat cta ctc tca gag gtc atc ttg gta gat gat gcc agt gaa aga gat        480
Tyr Leu Leu Ser Glu Val Ile Leu Val Asp Asp Ala Ser Glu Arg Asp           
145                 150                 155                 160           

ttt ctc aag ttg aca tta gag aat tac gtg aaa aat tta gaa gtg cca        528
Phe Leu Lys Leu Thr Leu Glu Asn Tyr Val Lys Asn Leu Glu Val Pro           
                165                 170                 175               

gta aaa att att agg atg gaa gaa cgc tct ggg tta ata cgt gcc cgt        576
Val Lys Ile Ile Arg Met Glu Glu Arg Ser Gly Leu Ile Arg Ala Arg           
            180                 185                 190                   

ctt cga gga gca gct gct tca aaa ggg cag gtc ata act ttt ctt gat        624
Leu Arg Gly Ala Ala Ala Ser Lys Gly Gln Val Ile Thr Phe Leu Asp           
        195                 200                 205                       

gca cac tgt gaa tgc acg tta gga tgg ctg gag cct ttg ctg gca aga        672
Ala His Cys Glu Cys Thr Leu Gly Trp Leu Glu Pro Leu Leu Ala Arg           
    210                 215                 220                           

ata aag gaa gac agg aaa acg gtt gtc tgc cct atc att gat gtg att        720
Ile Lys Glu Asp Arg Lys Thr Val Val Cys Pro Ile Ile Asp Val Ile           
225                 230                 235                 240           

agt gat gat act ttt gaa tat atg gct ggg tca gac atg act tat ggg        768
Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr Gly           
                245                 250                 255               

ggt ttt aac tgg aaa ctg aat ttc cgc tgg tat cct gtt ccc caa aga        816
Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln Arg           
            260                 265                 270                   

gaa atg gac agg agg aaa gga gac aga aca tta cct gtc aga ttt ggc        864
Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Phe Gly           
        275                 280                 285                       

aat gtg gag gct cct tgg aga ttg tta ctt gct ccc atg ttg gtc atg        912
Asn Val Glu Ala Pro Trp Arg Leu Leu Leu Ala Pro Met Leu Val Met           
    290                 295                 300                           

ttt ttc gga agg caa ctc cat aca ctt ttc ctg gtg gca ctg gtc atg        960
Phe Phe Gly Arg Gln Leu His Thr Leu Phe Leu Val Ala Leu Val Met           
305                 310                 315                 320           

tca tca aca aga aca aca gga gac tgg cag aag ttt gga tgg atg aat       1008
Ser Ser Thr Arg Thr Thr Gly Asp Trp Gln Lys Phe Gly Trp Met Asn           
                325                 330                 335               

tta aag att tct tct aca tca tat ccc cag ata aga aat gtt gaa acc       1056
Leu Lys Ile Ser Ser Thr Ser Tyr Pro Gln Ile Arg Asn Val Glu Thr           
            340                 345                 350                   

aat cag tgt tta gac aac atg ggc cgc aag gaa aat gaa aaa gta ttt       1104
Asn Gln Cys Leu Asp Asn Met Gly Arg Lys Glu Asn Glu Lys Val Phe           
        355                 360                 365                       

tct tac act gct gac aaa gaa atc cga acc gat gac ttg tgc ttg gat       1152
Ser Tyr Thr Ala Asp Lys Glu Ile Arg Thr Asp Asp Leu Cys Leu Asp           
    370                 375                 380                           

gtt tct aga ctc aat gga cct gta atc atg tta aaa tgc cac cat atg       1200
Val Ser Arg Leu Asn Gly Pro Val Ile Met Leu Lys Cys His His Met           
385                 390                 395                 400           

aga gga aat cag tta tgg gaa tat gat gct gag acc cac act ctt ctt       1248
Arg Gly Asn Gln Leu Trp Glu Tyr Asp Ala Glu Thr His Thr Leu Leu           
                405                 410                 415               

cat ata atc acc cag tct tgt ctc tca gtg aac aaa gta gct gat ggc       1296
His Ile Ile Thr Gln Ser Cys Leu Ser Val Asn Lys Val Ala Asp Gly           
            420                 425                 430                   

tcc cag cat cct act gtg gaa acc tgt aat gat agc act ttg caa aaa       1344
Ser Gln His Pro Thr Val Glu Thr Cys Asn Asp Ser Thr Leu Gln Lys           
        435                 440                 445                       

tgg cta cta aga aac tat aca aga atg gaa att ttt aga aat att ttt       1392
Trp Leu Leu Arg Asn Tyr Thr Arg Met Glu Ile Phe Arg Asn Ile Phe           
    450                 455                 460                           

ggg aat tct act gat tac att ctc taa tgatttttgg agagactcac             1439
Gly Asn Ser Thr Asp Tyr Ile Leu                                           
465                 470                                                   

gttgcgacat gttaacagta accaatgtct cgatgaacct tctgaagaag acaaaatggt     1499

gcctacaatg caggactgta gtggaagcag atcccaacag tggctgctaa ggaacatgac     1559

cttgggcaca tga                                                        1572


<210>  18
<211>  472
<212>  PRT
<213>  Homo sapiens (GalNAc-T13DelEx6DelEx8Del39bpEx9DelEx10B)

<400>  18

Met Arg Arg Phe Val Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Met 
1               5                   10                  15      


Trp Val Leu Val Asp Val Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn 
            20                  25                  30          


Lys Cys Asp Asp Lys Lys Glu Arg Ser Leu Leu Pro Ala Leu Arg Ala 
        35                  40                  45              


Val Ile Ser Arg Asn Gln Glu Gly Pro Gly Glu Met Gly Lys Ala Val 
    50                  55                  60                  


Leu Ile Pro Lys Asp Asp Gln Glu Lys Met Lys Glu Leu Phe Lys Ile 
65                  70                  75                  80  


Asn Gln Phe Asn Leu Met Ala Ser Asp Leu Ile Ala Leu Asn Arg Ser 
                85                  90                  95      


Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro Asp 
            100                 105                 110         


Glu Leu Pro Asn Thr Ser Val Val Ile Val Phe His Asn Glu Ala Trp 
        115                 120                 125             


Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Ile Asn Arg Ser Pro His 
    130                 135                 140                 


Tyr Leu Leu Ser Glu Val Ile Leu Val Asp Asp Ala Ser Glu Arg Asp 
145                 150                 155                 160 


Phe Leu Lys Leu Thr Leu Glu Asn Tyr Val Lys Asn Leu Glu Val Pro 
                165                 170                 175     


Val Lys Ile Ile Arg Met Glu Glu Arg Ser Gly Leu Ile Arg Ala Arg 
            180                 185                 190         


Leu Arg Gly Ala Ala Ala Ser Lys Gly Gln Val Ile Thr Phe Leu Asp 
        195                 200                 205             


Ala His Cys Glu Cys Thr Leu Gly Trp Leu Glu Pro Leu Leu Ala Arg 
    210                 215                 220                 


Ile Lys Glu Asp Arg Lys Thr Val Val Cys Pro Ile Ile Asp Val Ile 
225                 230                 235                 240 


Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr Gly 
                245                 250                 255     


Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln Arg 
            260                 265                 270         


Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Phe Gly 
        275                 280                 285             


Asn Val Glu Ala Pro Trp Arg Leu Leu Leu Ala Pro Met Leu Val Met 
    290                 295                 300                 


Phe Phe Gly Arg Gln Leu His Thr Leu Phe Leu Val Ala Leu Val Met 
305                 310                 315                 320 


Ser Ser Thr Arg Thr Thr Gly Asp Trp Gln Lys Phe Gly Trp Met Asn 
                325                 330                 335     


Leu Lys Ile Ser Ser Thr Ser Tyr Pro Gln Ile Arg Asn Val Glu Thr 
            340                 345                 350         


Asn Gln Cys Leu Asp Asn Met Gly Arg Lys Glu Asn Glu Lys Val Phe 
        355                 360                 365             


Ser Tyr Thr Ala Asp Lys Glu Ile Arg Thr Asp Asp Leu Cys Leu Asp 
    370                 375                 380                 


Val Ser Arg Leu Asn Gly Pro Val Ile Met Leu Lys Cys His His Met 
385                 390                 395                 400 


Arg Gly Asn Gln Leu Trp Glu Tyr Asp Ala Glu Thr His Thr Leu Leu 
                405                 410                 415     


His Ile Ile Thr Gln Ser Cys Leu Ser Val Asn Lys Val Ala Asp Gly 
            420                 425                 430         


Ser Gln His Pro Thr Val Glu Thr Cys Asn Asp Ser Thr Leu Gln Lys 
        435                 440                 445             


Trp Leu Leu Arg Asn Tyr Thr Arg Met Glu Ile Phe Arg Asn Ile Phe 
    450                 455                 460                 


Gly Asn Ser Thr Asp Tyr Ile Leu 
465                 470         


