                         SEQUENCE LISTING

<110>  MINERVA BIOTECHNOLOGIES CORPORATION
 
<120>  NME VARIANT SPECIES EXPRESSION AND SUPPRESSION

<130>  13150-70121PCT

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  1255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full-length MUC1 Receptor

<400>  1

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 
    50                  55                  60                  


Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu 
65                  70                  75                  80  


Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 
                85                  90                  95      


Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 
            100                 105                 110         


Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 
        115                 120                 125             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    130                 135                 140                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
145                 150                 155                 160 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                165                 170                 175     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            180                 185                 190         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        195                 200                 205             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    210                 215                 220                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
225                 230                 235                 240 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                245                 250                 255     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            260                 265                 270         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        275                 280                 285             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    290                 295                 300                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
305                 310                 315                 320 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                325                 330                 335     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            340                 345                 350         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        355                 360                 365             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    370                 375                 380                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
385                 390                 395                 400 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                405                 410                 415     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            420                 425                 430         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        435                 440                 445             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    450                 455                 460                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
465                 470                 475                 480 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                485                 490                 495     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            500                 505                 510         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        515                 520                 525             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    530                 535                 540                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
545                 550                 555                 560 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                565                 570                 575     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            580                 585                 590         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        595                 600                 605             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    610                 615                 620                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
625                 630                 635                 640 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                645                 650                 655     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            660                 665                 670         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        675                 680                 685             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    690                 695                 700                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
705                 710                 715                 720 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                725                 730                 735     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            740                 745                 750         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        755                 760                 765             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    770                 775                 780                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
785                 790                 795                 800 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                805                 810                 815     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            820                 825                 830         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        835                 840                 845             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    850                 855                 860                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
865                 870                 875                 880 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                885                 890                 895     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            900                 905                 910         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        915                 920                 925             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn 
    930                 935                 940                 


Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser 
945                 950                 955                 960 


Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly 
                965                 970                 975     


Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe 
            980                 985                 990         


Ser Ile Pro Ser His His Ser Asp  Thr Pro Thr Thr Leu  Ala Ser His 
        995                 1000                 1005             


Ser Thr  Lys Thr Asp Ala Ser  Ser Thr His His Ser  Ser Val Pro 
    1010                 1015                 1020             


Pro Leu  Thr Ser Ser Asn His  Ser Thr Ser Pro Gln  Leu Ser Thr 
    1025                 1030                 1035             


Gly Val  Ser Phe Phe Phe Leu  Ser Phe His Ile Ser  Asn Leu Gln 
    1040                 1045                 1050             


Phe Asn  Ser Ser Leu Glu Asp  Pro Ser Thr Asp Tyr  Tyr Gln Glu 
    1055                 1060                 1065             


Leu Gln  Arg Asp Ile Ser Glu  Met Phe Leu Gln Ile  Tyr Lys Gln 
    1070                 1075                 1080             


Gly Gly  Phe Leu Gly Leu Ser  Asn Ile Lys Phe Arg  Pro Gly Ser 
    1085                 1090                 1095             


Val Val  Val Gln Leu Thr Leu  Ala Phe Arg Glu Gly  Thr Ile Asn 
    1100                 1105                 1110             


Val His  Asp Val Glu Thr Gln  Phe Asn Gln Tyr Lys  Thr Glu Ala 
    1115                 1120                 1125             


Ala Ser  Arg Tyr Asn Leu Thr  Ile Ser Asp Val Ser  Val Ser Asp 
    1130                 1135                 1140             


Val Pro  Phe Pro Phe Ser Ala  Gln Ser Gly Ala Gly  Val Pro Gly 
    1145                 1150                 1155             


Trp Gly  Ile Ala Leu Leu Val  Leu Val Cys Val Leu  Val Ala Leu 
    1160                 1165                 1170             


Ala Ile  Val Tyr Leu Ile Ala  Leu Ala Val Cys Gln  Cys Arg Arg 
    1175                 1180                 1185             


Lys Asn  Tyr Gly Gln Leu Asp  Ile Phe Pro Ala Arg  Asp Thr Tyr 
    1190                 1195                 1200             


His Pro  Met Ser Glu Tyr Pro  Thr Tyr His Thr His  Gly Arg Tyr 
    1205                 1210                 1215             


Val Pro  Pro Ser Ser Thr Asp  Arg Ser Pro Tyr Glu  Lys Val Ser 
    1220                 1225                 1230             


Ala Gly  Asn Gly Gly Ser Ser  Leu Ser Tyr Thr Asn  Pro Ala Val 
    1235                 1240                 1245             


Ala Ala  Ala Ser Ala Asn Leu  
    1250                 1255 


<210>  2
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal MUC-1 signaling sequence

<400>  2

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr 
            


<210>  3
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal MUC-1 signaling sequence

<400>  3

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Ala 
            20              


<210>  4
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal MUC-1 signaling sequence

<400>  4

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly 
            20              


<210>  5
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated MUC1 receptor isoform

<400>  5

Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys 
1               5                   10                  15      


Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
            20                  25                  30          


Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro 
        35                  40                  45              


Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu 
    50                  55                  60                  


Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys 
65                  70                  75                  80  


Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro 
                85                  90                  95      


Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro 
            100                 105                 110         


Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly 
        115                 120                 125             


Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Ala Ser Ala 
    130                 135                 140                 


Asn Leu 
145     


<210>  6
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Native Primary Sequence of the MUC1 Growth Factor Receptor

<400>  6

Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys 
1               5                   10                  15      


Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
            20                  25                  30          


Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala 
        35                  40                  45  


<210>  7
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Native Primary Sequence of the MUC1 Growth Factor Receptor

<400>  7

Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
1               5                   10                  15      


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
            20                  25                  30          


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala 
        35                  40                  


<210>  8
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "SPY" functional variant of the native Primary Sequence of the 
       MUC1 Growth Factor Receptor

<400>  8

Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys 
1               5                   10                  15      


Thr Glu Ala Ala Ser Pro Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
            20                  25                  30          


Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala 
        35                  40                  45  


<210>  9
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "SPY" functional variant of the native Primary Sequence of the 
       MUC1 Growth Factor Receptor

<400>  9

Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
1               5                   10                  15      


Glu Ala Ala Ser Pro Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
            20                  25                  30          


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala 
        35                  40                  


<210>  10
<211>  216
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MUC1 cytoplasmic domain nucleotide sequence

<400>  10
tgtcagtgcc gccgaaagaa ctacgggcag ctggacatct ttccagcccg ggatacctac       60

catcctatga gcgagtaccc cacctaccac acccatgggc gctatgtgcc ccctagcagt      120

accgatcgta gcccctatga gaaggtttct gcaggtaacg gtggcagcag cctctcttac      180

acaaacccag cagtggcagc cgcttctgcc aacttg                                216


<210>  11
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC1 cytoplasmic domain amino acid sequence

<400>  11

Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala 
1               5                   10                  15      


Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His 
            20                  25                  30          


Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys 
        35                  40                  45              


Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala 
    50                  55                  60                  


Val Ala Ala Ala Ser Ala Asn Leu 
65                  70          


<210>  12
<211>  459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NM23 H1

<400>  12
atggccaact gtgagcgtac cttcattgcg atcaaaccag atggggtcca gcggggtctt       60

gtgggagaga ttatcaagcg ttttgagcag aaaggattcc gccttgttgg tctgaaattc      120

atgcaagctt ccgaagatct tctcaaggaa cactacgttg acctgaagga ccgtccattc      180

tttgccggcc tggtgaaata catgcactca gggccggtag ttgccatggt ctgggagggg      240

ctgaatgtgg tgaagacggg ccgagtcatg ctcggggaga ccaaccctgc agactccaag      300

cctgggacca tccgtggaga cttctgcata caagttggca ggaacattat acatggcagt      360

gattctgtgg agagtgcaga gaaggagatc ggcttgtggt ttcaccctga ggaactggta      420

gattacacga gctgtgctca gaactggatc tatgaatga                             459


<210>  13
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NM23 H1

<400>  13

Met Ala Asn Cys Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val 
1               5                   10                  15      


Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly 
            20                  25                  30          


Phe Arg Leu Val Gly Leu Lys Phe Met Gln Ala Ser Glu Asp Leu Leu 
        35                  40                  45              


Lys Glu His Tyr Val Asp Leu Lys Asp Arg Pro Phe Phe Ala Gly Leu 
    50                  55                  60                  


Val Lys Tyr Met His Ser Gly Pro Val Val Ala Met Val Trp Glu Gly 
65                  70                  75                  80  


Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro 
                85                  90                  95      


Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val 
            100                 105                 110         


Gly Arg Asn Ile Ile His Gly Ser Asp Ser Val Glu Ser Ala Glu Lys 
        115                 120                 125             


Glu Ile Gly Leu Trp Phe His Pro Glu Glu Leu Val Asp Tyr Thr Ser 
    130                 135                 140                 


Cys Ala Gln Asn Trp Ile Tyr Glu 
145                 150         


<210>  14
<211>  459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse NM23 H1

<400>  14
atggccaaca gtgagcgcac cttcattgcc atcaagcctg atggggtcca gcgggggctg       60

gtgggcgaga tcatcaagcg gttcgagcag aaggggttcc gccttgttgg tctgaagttt      120

ctgcaggctt cagaggacct tctcaaggag cactacactg acctgaagga ccgccccttc      180

tttactggcc tggtgaaata catgcactca ggaccagtgg ttgctatggt ctgggagggt      240

ctgaatgtgg tgaagacagg ccgcgtgatg cttggagaga ccaaccccgc agactctaag      300

cctgggacca tacgaggaga cttctgcatc caagttggca ggaacatcat tcatggcagc      360

gattctgtaa agagcgcaga gaaggagatc agcttgtggt ttcagcctga ggagctggtg      420

gagtacaaga gctgtgcgca gaactggatc tatgagtga                             459


<210>  15
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse NM23 H1

<400>  15

Met Ala Asn Ser Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val 
1               5                   10                  15      


Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly 
            20                  25                  30          


Phe Arg Leu Val Gly Leu Lys Phe Leu Gln Ala Ser Glu Asp Leu Leu 
        35                  40                  45              


Lys Glu His Tyr Thr Asp Leu Lys Asp Arg Pro Phe Phe Thr Gly Leu 
    50                  55                  60                  


Val Lys Tyr Met His Ser Gly Pro Val Val Ala Met Val Trp Glu Gly 
65                  70                  75                  80  


Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro 
                85                  90                  95      


Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val 
            100                 105                 110         


Gly Arg Asn Ile Ile His Gly Ser Asp Ser Val Lys Ser Ala Glu Lys 
        115                 120                 125             


Glu Ile Ser Leu Trp Phe Gln Pro Glu Glu Leu Val Glu Tyr Lys Ser 
    130                 135                 140                 


Cys Ala Gln Asn Trp Ile Tyr Glu 
145                 150         


<210>  16
<211>  459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NM23 H2

<400>  16
atggccaacc tggagcgcac cttcatcgcc atcaagccgg acggcgtgca gcgcggcctg       60

gtgggcgaga tcatcaagcg cttcgagcag aagggattcc gcctcgtggc catgaagttc      120

ctccgggcct ctgaagaaca cctgaagcag cactacattg acctgaaaga ccgaccattc      180

ttccctgggc tggtgaagta catgaactca gggccggttg tggccatggt ctgggagggg      240

ctgaacgtgg tgaagacagg ccgagtgatg cttggggaga ccaatccagc agattcaaag      300

ccaggcacca ttcgtgggga cttctgcatt caggttggca ggaacatcat tcatggcagt      360

gattcagtaa aaagtgctga aaaagaaatc agcctatggt ttaagcctga agaactggtt      420

gactacaagt cttgtgctca tgactgggtc tatgaataa                             459


<210>  17
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NM23 H2

<400>  17

Met Ala Asn Leu Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val 
1               5                   10                  15      


Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly 
            20                  25                  30          


Phe Arg Leu Val Ala Met Lys Phe Leu Arg Ala Ser Glu Glu His Leu 
        35                  40                  45              


Lys Gln His Tyr Ile Asp Leu Lys Asp Arg Pro Phe Phe Pro Gly Leu 
    50                  55                  60                  


Val Lys Tyr Met Asn Ser Gly Pro Val Val Ala Met Val Trp Glu Gly 
65                  70                  75                  80  


Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro 
                85                  90                  95      


Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val 
            100                 105                 110         


Gly Arg Asn Ile Ile His Gly Ser Asp Ser Val Lys Ser Ala Glu Lys 
        115                 120                 125             


Glu Ile Ser Leu Trp Phe Lys Pro Glu Glu Leu Val Asp Tyr Lys Ser 
    130                 135                 140                 


Cys Ala His Asp Trp Val Tyr Glu 
145                 150         


<210>  18
<211>  459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse NM23 H2

<400>  18
atggccaacc tcgagcgtac cttcattgcc atcaagccag atggcgtgca gcgcggcctg       60

gtgggcgaga tcatcaaacg gttcgagcag aaggggttcc gcctggtggc catgaagttc      120

cttcgggcct ctgaagaaca cctgaagcag cattacatcg acctgaaaga ccgtcctttc      180

ttcccggggc tggtgaagta catgaactcg gggcccgtgg tggccatggt ctgggagggg      240

ctcaatgtgg tgaaaacggg ccgagtgatg ctgggggaga ccaatccagc tgattcaaaa      300

ccaggcacca tccgtgggga tttctgcatt caagttggca ggaacatcat tcatggcagt      360

gattcagtgg agagtgctga gaaagagatc catctgtggt ttaagcccga agaactgatc      420

gactacaagt cttgtgccca tgactgggtg tacgagtag                             459


<210>  19
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse NM23 H2

<400>  19

Met Ala Asn Leu Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val 
1               5                   10                  15      


Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly 
            20                  25                  30          


Phe Arg Leu Val Ala Met Lys Phe Leu Arg Ala Ser Glu Glu His Leu 
        35                  40                  45              


Lys Gln His Tyr Ile Asp Leu Lys Asp Arg Pro Phe Phe Pro Gly Leu 
    50                  55                  60                  


Val Lys Tyr Met Asn Ser Gly Pro Val Val Ala Met Val Trp Glu Gly 
65                  70                  75                  80  


Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro 
                85                  90                  95      


Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val 
            100                 105                 110         


Gly Arg Asn Ile Ile His Gly Ser Asp Ser Val Glu Ser Ala Glu Lys 
        115                 120                 125             


Glu Ile His Leu Trp Phe Lys Pro Glu Glu Leu Ile Asp Tyr Lys Ser 
    130                 135                 140                 


Cys Ala His Asp Trp Val Tyr Glu 
145                 150         


<210>  20
<211>  570
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse NME6

<400>  20
atgacctcca tcttgcgaag tccccaagct cttcagctca cactagccct gatcaagcct       60

gatgcagttg cccacccact gatcctggag gctgttcatc agcagattct gagcaacaag      120

ttcctcattg tacgaacgag ggaactgcag tggaagctgg aggactgccg gaggttttac      180

cgagagcatg aagggcgttt tttctatcag cggctggtgg agttcatgac aagtgggcca      240

atccgagcct atatccttgc ccacaaagat gccatccaac tttggaggac actgatggga      300

cccaccagag tatttcgagc acgctatata gccccagatt caattcgtgg aagtttgggc      360

ctcactgaca cccgaaatac tacccatggc tcagactccg tggtttccgc cagcagagag      420

attgcagcct tcttccctga cttcagtgaa cagcgctggt atgaggagga ggaaccccag      480

ctgcggtgtg gtcctgtgca ctacagtcca gaggaaggta tccactgtgc agctgaaaca      540

ggaggccaca aacaacctaa caaaacctag                                       570


<210>  21
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse NME6

<400>  21

Met Thr Ser Ile Leu Arg Ser Pro Gln Ala Leu Gln Leu Thr Leu Ala 
1               5                   10                  15      


Leu Ile Lys Pro Asp Ala Val Ala His Pro Leu Ile Leu Glu Ala Val 
            20                  25                  30          


His Gln Gln Ile Leu Ser Asn Lys Phe Leu Ile Val Arg Thr Arg Glu 
        35                  40                  45              


Leu Gln Trp Lys Leu Glu Asp Cys Arg Arg Phe Tyr Arg Glu His Glu 
    50                  55                  60                  


Gly Arg Phe Phe Tyr Gln Arg Leu Val Glu Phe Met Thr Ser Gly Pro 
65                  70                  75                  80  


Ile Arg Ala Tyr Ile Leu Ala His Lys Asp Ala Ile Gln Leu Trp Arg 
                85                  90                  95      


Thr Leu Met Gly Pro Thr Arg Val Phe Arg Ala Arg Tyr Ile Ala Pro 
            100                 105                 110         


Asp Ser Ile Arg Gly Ser Leu Gly Leu Thr Asp Thr Arg Asn Thr Thr 
        115                 120                 125             


His Gly Ser Asp Ser Val Val Ser Ala Ser Arg Glu Ile Ala Ala Phe 
    130                 135                 140                 


Phe Pro Asp Phe Ser Glu Gln Arg Trp Tyr Glu Glu Glu Glu Pro Gln 
145                 150                 155                 160 


Leu Arg Cys Gly Pro Val His Tyr Ser Pro Glu Glu Gly Ile His Cys 
                165                 170                 175     


Ala Ala Glu Thr Gly Gly His Lys Gln Pro Asn Lys Thr 
            180                 185                 


<210>  22
<211>  585
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME6

<400>  22
atgacccaga atctggggag tgagatggcc tcaatcttgc gaagccctca ggctctccag       60

ctcactctag ccctgatcaa gcctgacgca gtcgcccatc cactgattct ggaggctgtt      120

catcagcaga ttctaagcaa caagttcctg attgtacgaa tgagagaact actgtggaga      180

aaggaagatt gccagaggtt ttaccgagag catgaagggc gttttttcta tcagaggctg      240

gtggagttca tggccagcgg gccaatccga gcctacatcc ttgcccacaa ggatgccatc      300

cagctctgga ggacgctcat gggacccacc agagtgttcc gagcacgcca tgtggcccca      360

gattctatcc gtgggagttt cggcctcact gacacccgca acaccaccca tggttcggac      420

tctgtggttt cagccagcag agagattgca gccttcttcc ctgacttcag tgaacagcgc      480

tggtatgagg aggaagagcc ccagttgcgc tgtggccctg tgtgctatag cccagaggga      540

ggtgtccact atgtagctgg aacaggaggc ctaggaccag cctga                      585


<210>  23
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME6

<400>  23

Met Thr Gln Asn Leu Gly Ser Glu Met Ala Ser Ile Leu Arg Ser Pro 
1               5                   10                  15      


Gln Ala Leu Gln Leu Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ala 
            20                  25                  30          


His Pro Leu Ile Leu Glu Ala Val His Gln Gln Ile Leu Ser Asn Lys 
        35                  40                  45              


Phe Leu Ile Val Arg Met Arg Glu Leu Leu Trp Arg Lys Glu Asp Cys 
    50                  55                  60                  


Gln Arg Phe Tyr Arg Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu 
65                  70                  75                  80  


Val Glu Phe Met Ala Ser Gly Pro Ile Arg Ala Tyr Ile Leu Ala His 
                85                  90                  95      


Lys Asp Ala Ile Gln Leu Trp Arg Thr Leu Met Gly Pro Thr Arg Val 
            100                 105                 110         


Phe Arg Ala Arg His Val Ala Pro Asp Ser Ile Arg Gly Ser Phe Gly 
        115                 120                 125             


Leu Thr Asp Thr Arg Asn Thr Thr His Gly Ser Asp Ser Val Val Ser 
    130                 135                 140                 


Ala Ser Arg Glu Ile Ala Ala Phe Phe Pro Asp Phe Ser Glu Gln Arg 
145                 150                 155                 160 


Trp Tyr Glu Glu Glu Glu Pro Gln Leu Arg Cys Gly Pro Val Cys Tyr 
                165                 170                 175     


Ser Pro Glu Gly Gly Val His Tyr Val Ala Gly Thr Gly Gly Leu Gly 
            180                 185                 190         


Pro Ala 
        


<210>  24
<211>  525
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME6 1

<400>  24
atgacccaga atctggggag tgagatggcc tcaatcttgc gaagccctca ggctctccag       60

ctcactctag ccctgatcaa gcctgacgca gtcgcccatc cactgattct ggaggctgtt      120

catcagcaga ttctaagcaa caagttcctg attgtacgaa tgagagaact actgtggaga      180

aaggaagatt gccagaggtt ttaccgagag catgaagggc gttttttcta tcagaggctg      240

gtggagttca tggccagcgg gccaatccga gcctacatcc ttgcccacaa ggatgccatc      300

cagctctgga ggacgctcat gggacccacc agagtgttcc gagcacgcca tgtggcccca      360

gattctatcc gtgggagttt cggcctcact gacacccgca acaccaccca tggttcggac      420

tctgtggttt cagccagcag agagattgca gccttcttcc ctgacttcag tgaacagcgc      480

tggtatgagg aggaagagcc ccagttgcgc tgtggccctg tgtga                      525


<210>  25
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME6 1

<400>  25

Met Thr Gln Asn Leu Gly Ser Glu Met Ala Ser Ile Leu Arg Ser Pro 
1               5                   10                  15      


Gln Ala Leu Gln Leu Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ala 
            20                  25                  30          


His Pro Leu Ile Leu Glu Ala Val His Gln Gln Ile Leu Ser Asn Lys 
        35                  40                  45              


Phe Leu Ile Val Arg Met Arg Glu Leu Leu Trp Arg Lys Glu Asp Cys 
    50                  55                  60                  


Gln Arg Phe Tyr Arg Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu 
65                  70                  75                  80  


Val Glu Phe Met Ala Ser Gly Pro Ile Arg Ala Tyr Ile Leu Ala His 
                85                  90                  95      


Lys Asp Ala Ile Gln Leu Trp Arg Thr Leu Met Gly Pro Thr Arg Val 
            100                 105                 110         


Phe Arg Ala Arg His Val Ala Pro Asp Ser Ile Arg Gly Ser Phe Gly 
        115                 120                 125             


Leu Thr Asp Thr Arg Asn Thr Thr His Gly Ser Asp Ser Val Val Ser 
    130                 135                 140                 


Ala Ser Arg Glu Ile Ala Ala Phe Phe Pro Asp Phe Ser Glu Gln Arg 
145                 150                 155                 160 


Trp Tyr Glu Glu Glu Glu Pro Gln Leu Arg Cys Gly Pro Val 
                165                 170                 


<210>  26
<211>  468
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME6 2

<400>  26
atgctcactc tagccctgat caagcctgac gcagtcgccc atccactgat tctggaggct       60

gttcatcagc agattctaag caacaagttc ctgattgtac gaatgagaga actactgtgg      120

agaaaggaag attgccagag gttttaccga gagcatgaag ggcgtttttt ctatcagagg      180

ctggtggagt tcatggccag cgggccaatc cgagcctaca tccttgccca caaggatgcc      240

atccagctct ggaggacgct catgggaccc accagagtgt tccgagcacg ccatgtggcc      300

ccagattcta tccgtgggag tttcggcctc actgacaccc gcaacaccac ccatggttcg      360

gactctgtgg tttcagccag cagagagatt gcagccttct tccctgactt cagtgaacag      420

cgctggtatg aggaggaaga gccccagttg cgctgtggcc ctgtgtga                   468


<210>  27
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME6 2

<400>  27

Met Leu Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ala His Pro Leu 
1               5                   10                  15      


Ile Leu Glu Ala Val His Gln Gln Ile Leu Ser Asn Lys Phe Leu Ile 
            20                  25                  30          


Val Arg Met Arg Glu Leu Leu Trp Arg Lys Glu Asp Cys Gln Arg Phe 
        35                  40                  45              


Tyr Arg Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu Val Glu Phe 
    50                  55                  60                  


Met Ala Ser Gly Pro Ile Arg Ala Tyr Ile Leu Ala His Lys Asp Ala 
65                  70                  75                  80  


Ile Gln Leu Trp Arg Thr Leu Met Gly Pro Thr Arg Val Phe Arg Ala 
                85                  90                  95      


Arg His Val Ala Pro Asp Ser Ile Arg Gly Ser Phe Gly Leu Thr Asp 
            100                 105                 110         


Thr Arg Asn Thr Thr His Gly Ser Asp Ser Val Val Ser Ala Ser Arg 
        115                 120                 125             


Glu Ile Ala Ala Phe Phe Pro Asp Phe Ser Glu Gln Arg Trp Tyr Glu 
    130                 135                 140                 


Glu Glu Glu Pro Gln Leu Arg Cys Gly Pro Val 
145                 150                 155 


<210>  28
<211>  528
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME6 3

<400>  28
atgctcactc tagccctgat caagcctgac gcagtcgccc atccactgat tctggaggct       60

gttcatcagc agattctaag caacaagttc ctgattgtac gaatgagaga actactgtgg      120

agaaaggaag attgccagag gttttaccga gagcatgaag ggcgtttttt ctatcagagg      180

ctggtggagt tcatggccag cgggccaatc cgagcctaca tccttgccca caaggatgcc      240

atccagctct ggaggacgct catgggaccc accagagtgt tccgagcacg ccatgtggcc      300

ccagattcta tccgtgggag tttcggcctc actgacaccc gcaacaccac ccatggttcg      360

gactctgtgg tttcagccag cagagagatt gcagccttct tccctgactt cagtgaacag      420

cgctggtatg aggaggaaga gccccagttg cgctgtggcc ctgtgtgcta tagcccagag      480

ggaggtgtcc actatgtagc tggaacagga ggcctaggac cagcctga                   528


<210>  29
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME6 3

<400>  29

Met Leu Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ala His Pro Leu 
1               5                   10                  15      


Ile Leu Glu Ala Val His Gln Gln Ile Leu Ser Asn Lys Phe Leu Ile 
            20                  25                  30          


Val Arg Met Arg Glu Leu Leu Trp Arg Lys Glu Asp Cys Gln Arg Phe 
        35                  40                  45              


Tyr Arg Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu Val Glu Phe 
    50                  55                  60                  


Met Ala Ser Gly Pro Ile Arg Ala Tyr Ile Leu Ala His Lys Asp Ala 
65                  70                  75                  80  


Ile Gln Leu Trp Arg Thr Leu Met Gly Pro Thr Arg Val Phe Arg Ala 
                85                  90                  95      


Arg His Val Ala Pro Asp Ser Ile Arg Gly Ser Phe Gly Leu Thr Asp 
            100                 105                 110         


Thr Arg Asn Thr Thr His Gly Ser Asp Ser Val Val Ser Ala Ser Arg 
        115                 120                 125             


Glu Ile Ala Ala Phe Phe Pro Asp Phe Ser Glu Gln Arg Trp Tyr Glu 
    130                 135                 140                 


Glu Glu Glu Pro Gln Leu Arg Cys Gly Pro Val Cys Tyr Ser Pro Glu 
145                 150                 155                 160 


Gly Gly Val His Tyr Val Ala Gly Thr Gly Gly Leu Gly Pro Ala 
                165                 170                 175 


<210>  30
<211>  1131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NM23-H7-1

<400>  30
atgaatcata gtgaaagatt cgttttcatt gcagagtggt atgatccaaa tgcttcactt       60

cttcgacgtt atgagctttt attttaccca ggggatggat ctgttgaaat gcatgatgta      120

aagaatcatc gcaccttttt aaagcggacc aaatatgata acctgcactt ggaagattta      180

tttataggca acaaagtgaa tgtcttttct cgacaactgg tattaattga ctatggggat      240

caatatacag ctcgccagct gggcagtagg aaagaaaaaa cgctagccct aattaaacca      300

gatgcaatat caaaggctgg agaaataatt gaaataataa acaaagctgg atttactata      360

accaaactca aaatgatgat gctttcaagg aaagaagcat tggattttca tgtagatcac      420

cagtcaagac cctttttcaa tgagctgatc cagtttatta caactggtcc tattattgcc      480

atggagattt taagagatga tgctatatgt gaatggaaaa gactgctggg acctgcaaac      540

tctggagtgg cacgcacaga tgcttctgaa agcattagag ccctctttgg aacagatggc      600

ataagaaatg cagcgcatgg ccctgattct tttgcttctg cggccagaga aatggagttg      660

ttttttcctt caagtggagg ttgtgggccg gcaaacactg ctaaatttac taattgtacc      720

tgttgcattg ttaaacccca tgctgtcagt gaaggactgt tgggaaagat cctgatggct      780

atccgagatg caggttttga aatctcagct atgcagatgt tcaatatgga tcgggttaat      840

gttgaggaat tctatgaagt ttataaagga gtagtgaccg aatatcatga catggtgaca      900

gaaatgtatt ctggcccttg tgtagcaatg gagattcaac agaataatgc tacaaagaca      960

tttcgagaat tttgtggacc tgctgatcct gaaattgccc ggcatttacg ccctggaact     1020

ctcagagcaa tctttggtaa aactaagatc cagaatgctg ttcactgtac tgatctgcca     1080

gaggatggcc tattagaggt tcaatacttc ttcaagatct tggataatta g              1131


<210>  31
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NM23-H7-1

<400>  31

Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu Trp Tyr Asp Pro 
1               5                   10                  15      


Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe Tyr Pro Gly Asp 
            20                  25                  30          


Gly Ser Val Glu Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys 
        35                  40                  45              


Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn 
    50                  55                  60                  


Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp 
65                  70                  75                  80  


Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala 
                85                  90                  95      


Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile 
            100                 105                 110         


Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu 
        115                 120                 125             


Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro 
    130                 135                 140                 


Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala 
145                 150                 155                 160 


Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu 
                165                 170                 175     


Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile 
            180                 185                 190         


Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro 
        195                 200                 205             


Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu Phe Phe Pro Ser 
    210                 215                 220                 


Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr Asn Cys Thr 
225                 230                 235                 240 


Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu Leu Gly Lys 
                245                 250                 255     


Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met Gln 
            260                 265                 270         


Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val Tyr 
        275                 280                 285             


Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr Ser 
    290                 295                 300                 


Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys Thr 
305                 310                 315                 320 


Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His Leu 
                325                 330                 335     


Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn 
            340                 345                 350         


Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val Gln 
        355                 360                 365             


Tyr Phe Phe Lys Ile Leu Asp Asn 
    370                 375     


<210>  32
<211>  1131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NM23-H7-1 sequence optimized for E. coli expression

<400>  32
atgaatcact ccgaacgctt tgtttttatc gccgaatggt atgacccgaa tgcttccctg       60

ctgcgccgct acgaactgct gttttatccg ggcgatggta gcgtggaaat gcatgacgtt      120

aaaaatcacc gtacctttct gaaacgcacg aaatatgata atctgcatct ggaagacctg      180

tttattggca acaaagtcaa tgtgttctct cgtcagctgg tgctgatcga ttatggcgac      240

cagtacaccg cgcgtcaact gggtagtcgc aaagaaaaaa cgctggccct gattaaaccg      300

gatgcaatct ccaaagctgg cgaaattatc gaaattatca acaaagcggg tttcaccatc      360

acgaaactga aaatgatgat gctgagccgt aaagaagccc tggattttca tgtcgaccac      420

cagtctcgcc cgtttttcaa tgaactgatt caattcatca ccacgggtcc gattatcgca      480

atggaaattc tgcgtgatga cgctatctgc gaatggaaac gcctgctggg cccggcaaac      540

tcaggtgttg cgcgtaccga tgccagtgaa tccattcgcg ctctgtttgg caccgatggt      600

atccgtaatg cagcacatgg tccggactca ttcgcatcgg cagctcgtga aatggaactg      660

tttttcccga gctctggcgg ttgcggtccg gcaaacaccg ccaaatttac caattgtacg      720

tgctgtattg tcaaaccgca cgcagtgtca gaaggcctgc tgggtaaaat tctgatggca      780

atccgtgatg ctggctttga aatctcggcc atgcagatgt tcaacatgga ccgcgttaac      840

gtcgaagaat tctacgaagt ttacaaaggc gtggttaccg aatatcacga tatggttacg      900

gaaatgtact ccggtccgtg cgtcgcgatg gaaattcagc aaaacaatgc caccaaaacg      960

tttcgtgaat tctgtggtcc ggcagatccg gaaatcgcac gtcatctgcg tccgggtacc     1020

ctgcgcgcaa tttttggtaa aacgaaaatc cagaacgctg tgcactgtac cgatctgccg     1080

gaagacggtc tgctggaagt tcaatacttt ttcaaaattc tggataatta g              1131


<210>  33
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NM23-H7-1 sequence optimized for E. coli expression

<400>  33

Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu Trp Tyr Asp Pro 
1               5                   10                  15      


Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe Tyr Pro Gly Asp 
            20                  25                  30          


Gly Ser Val Glu Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys 
        35                  40                  45              


Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn 
    50                  55                  60                  


Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp 
65                  70                  75                  80  


Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala 
                85                  90                  95      


Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile 
            100                 105                 110         


Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu 
        115                 120                 125             


Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro 
    130                 135                 140                 


Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala 
145                 150                 155                 160 


Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu 
                165                 170                 175     


Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile 
            180                 185                 190         


Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro 
        195                 200                 205             


Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu Phe Phe Pro Ser 
    210                 215                 220                 


Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr Asn Cys Thr 
225                 230                 235                 240 


Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu Leu Gly Lys 
                245                 250                 255     


Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met Gln 
            260                 265                 270         


Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val Tyr 
        275                 280                 285             


Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr Ser 
    290                 295                 300                 


Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys Thr 
305                 310                 315                 320 


Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His Leu 
                325                 330                 335     


Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn 
            340                 345                 350         


Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val Gln 
        355                 360                 365             


Tyr Phe Phe Lys Ile Leu Asp Asn 
    370                 375     


<210>  34
<211>  1023
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NM23-H7-2

<400>  34
atgcatgatg taaagaatca tcgcaccttt ttaaagcgga ccaaatatga taacctgcac       60

ttggaagatt tatttatagg caacaaagtg aatgtctttt ctcgacaact ggtattaatt      120

gactatgggg atcaatatac agctcgccag ctgggcagta ggaaagaaaa aacgctagcc      180

ctaattaaac cagatgcaat atcaaaggct ggagaaataa ttgaaataat aaacaaagct      240

ggatttacta taaccaaact caaaatgatg atgctttcaa ggaaagaagc attggatttt      300

catgtagatc accagtcaag accctttttc aatgagctga tccagtttat tacaactggt      360

cctattattg ccatggagat tttaagagat gatgctatat gtgaatggaa aagactgctg      420

ggacctgcaa actctggagt ggcacgcaca gatgcttctg aaagcattag agccctcttt      480

ggaacagatg gcataagaaa tgcagcgcat ggccctgatt cttttgcttc tgcggccaga      540

gaaatggagt tgttttttcc ttcaagtgga ggttgtgggc cggcaaacac tgctaaattt      600

actaattgta cctgttgcat tgttaaaccc catgctgtca gtgaaggact gttgggaaag      660

atcctgatgg ctatccgaga tgcaggtttt gaaatctcag ctatgcagat gttcaatatg      720

gatcgggtta atgttgagga attctatgaa gtttataaag gagtagtgac cgaatatcat      780

gacatggtga cagaaatgta ttctggccct tgtgtagcaa tggagattca acagaataat      840

gctacaaaga catttcgaga attttgtgga cctgctgatc ctgaaattgc ccggcattta      900

cgccctggaa ctctcagagc aatctttggt aaaactaaga tccagaatgc tgttcactgt      960

actgatctgc cagaggatgg cctattagag gttcaatact tcttcaagat cttggataat     1020

tga                                                                   1023


<210>  35
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NM23-H7-2

<400>  35

Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys Arg Thr Lys Tyr 
1               5                   10                  15      


Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn Lys Val Asn Val 
            20                  25                  30          


Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp Gln Tyr Thr Ala 
        35                  40                  45              


Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala Leu Ile Lys Pro 
    50                  55                  60                  


Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala 
65                  70                  75                  80  


Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu Ser Arg Lys Glu 
                85                  90                  95      


Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro Phe Phe Asn Glu 
            100                 105                 110         


Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala Met Glu Ile Leu 
        115                 120                 125             


Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn 
    130                 135                 140                 


Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe 
145                 150                 155                 160 


Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro Asp Ser Phe Ala 
                165                 170                 175     


Ser Ala Ala Arg Glu Met Glu Leu Phe Phe Pro Ser Ser Gly Gly Cys 
            180                 185                 190         


Gly Pro Ala Asn Thr Ala Lys Phe Thr Asn Cys Thr Cys Cys Ile Val 
        195                 200                 205             


Lys Pro His Ala Val Ser Glu Gly Leu Leu Gly Lys Ile Leu Met Ala 
    210                 215                 220                 


Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met Gln Met Phe Asn Met 
225                 230                 235                 240 


Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val Tyr Lys Gly Val Val 
                245                 250                 255     


Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr Ser Gly Pro Cys Val 
            260                 265                 270         


Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys Thr Phe Arg Glu Phe 
        275                 280                 285             


Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His Leu Arg Pro Gly Thr 
    290                 295                 300                 


Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn Ala Val His Cys 
305                 310                 315                 320 


Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val Gln Tyr Phe Phe Lys 
                325                 330                 335     


Ile Leu Asp Asn 
            340 


<210>  36
<211>  1188
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse NM23-H7-1

<400>  36
atgagagcct gtcagcaggg aagaagttcc agtttggttt ctccatatat ggcacccaag       60

aatcagagcg agagattcgc tttcattgca gagtggtatg atccaaatgc ttcattgctc      120

cgacgctatg agctgctgtt ttaccccaca gacggatctg ttgaaatgca tgatgtaaag      180

aatcgtcgca ccttcttaaa gcggaccaag tatgaggacc tgcgcctgga agatctattt      240

ataggcaaca aagtcaatgt gttttctcga cagctggtgt tgattgacta tggggaccaa      300

tacacagccc gccagctggg cagcaggaaa gagaaaactt tagccctgat caaaccagat      360

gcagtgtcaa aggccggaga aatcattgag atgataaaca aaagtggatt tactataacc      420

aaactccgaa tgatgactct gacaaggaaa gaagcagcgg actttcatgt agaccatcac      480

tcaagacctt tttataacga actgatccag tttatcacaa gtgggcctgt tattgccatg      540

gagatcttaa gagatgacgc gatctgtgag tggaaaaggt tgcttggacc cgcaaactct      600

gggctatcac ggacagatgc ccccggaagc atccgagccc tctttgggac agatggcgtg      660

agaaatgcag ctcacggccc tgatactttt gcatctgctg ccagagaaat ggaattgttt      720

tttccttcaa gtggaggctg tgggccagcg aacactgcta aatttaccaa ttgcacctgt      780

tgcatcatta agcctcatgc tatcagtgaa ggaatgttgg gaaagatttt aatagctatt      840

cgggatgcat gctttggaat gtcagcgata cagatgttca atttggatcg ggctaatgtt      900

gaagaattct atgaagtcta taaaggtgta gtgtctgagt ataatgatat ggtgacagag      960

ctgtgctccg gcccttgcgt agcaatagag atccaacaga gcaaccctac aaagacattt     1020

cgagaattct gcggacctgc tgatcctgaa atcgcccggc atttacgacc tgagaccctc     1080

agggcaattt ttggtaaaac taaggttcaa aatgctgttc attgcacgga tctgccggag     1140

gatgggctcc tggaggtcca gtatttcttc aagatcttgg ataattag                  1188


<210>  37
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse NM23-H7-1

<400>  37

Met Arg Ala Cys Gln Gln Gly Arg Ser Ser Ser Leu Val Ser Pro Tyr 
1               5                   10                  15      


Met Ala Pro Lys Asn Gln Ser Glu Arg Phe Ala Phe Ile Ala Glu Trp 
            20                  25                  30          


Tyr Asp Pro Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe Tyr 
        35                  40                  45              


Pro Thr Asp Gly Ser Val Glu Met His Asp Val Lys Asn Arg Arg Thr 
    50                  55                  60                  


Phe Leu Lys Arg Thr Lys Tyr Glu Asp Leu Arg Leu Glu Asp Leu Phe 
65                  70                  75                  80  


Ile Gly Asn Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile Asp 
                85                  90                  95      


Tyr Gly Asp Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu Lys 
            100                 105                 110         


Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ser Lys Ala Gly Glu Ile 
        115                 120                 125             


Ile Glu Met Ile Asn Lys Ser Gly Phe Thr Ile Thr Lys Leu Arg Met 
    130                 135                 140                 


Met Thr Leu Thr Arg Lys Glu Ala Ala Asp Phe His Val Asp His His 
145                 150                 155                 160 


Ser Arg Pro Phe Tyr Asn Glu Leu Ile Gln Phe Ile Thr Ser Gly Pro 
                165                 170                 175     


Val Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys 
            180                 185                 190         


Arg Leu Leu Gly Pro Ala Asn Ser Gly Leu Ser Arg Thr Asp Ala Pro 
        195                 200                 205             


Gly Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Val Arg Asn Ala Ala 
    210                 215                 220                 


His Gly Pro Asp Thr Phe Ala Ser Ala Ala Arg Glu Met Glu Leu Phe 
225                 230                 235                 240 


Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr 
                245                 250                 255     


Asn Cys Thr Cys Cys Ile Ile Lys Pro His Ala Ile Ser Glu Gly Met 
            260                 265                 270         


Leu Gly Lys Ile Leu Ile Ala Ile Arg Asp Ala Cys Phe Gly Met Ser 
        275                 280                 285             


Ala Ile Gln Met Phe Asn Leu Asp Arg Ala Asn Val Glu Glu Phe Tyr 
    290                 295                 300                 


Glu Val Tyr Lys Gly Val Val Ser Glu Tyr Asn Asp Met Val Thr Glu 
305                 310                 315                 320 


Leu Cys Ser Gly Pro Cys Val Ala Ile Glu Ile Gln Gln Ser Asn Pro 
                325                 330                 335     


Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala 
            340                 345                 350         


Arg His Leu Arg Pro Glu Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys 
        355                 360                 365             


Val Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu 
    370                 375                 380                 


Glu Val Gln Tyr Phe Phe Lys Ile Leu Asp Asn 
385                 390                 395 


<210>  38
<211>  834
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse NM23-H7-2

<400>  38
atgagagcct gtcagcaggg aagaagttcc agtttggttt ctccatatat ggcacccaag       60

aatcagagcg agagattcgc tttcattgca gagtggtatg atccaaatgc ttcattgctc      120

cgacgctatg agctgctgtt ttaccccaca gacggatctg ttgaaatgca tgatgtaaag      180

aatcgtcgca ccttcttaaa gcggaccaag tatgaggacc tgcgcctgga agatctattt      240

ataggcaaca aagtcaatgt gttttctcga cagctggtgt tgattgacta tggggaccaa      300

tacacagccc gccagctggg cagcaggaaa gagaaaactt tagccctgat caaaccagat      360

gcagtgtcaa aggccggaga aatcattgag atgataaaca aaagtggatt tactataacc      420

aaactccgaa tgatgactct gacaaggaaa gaagcagcgg actttcatgt agaccatcac      480

tcaagacctt tttataacga actgatccag tttatcacaa gtgggcctgt tattgccatg      540

gagatcttaa gagatgacgc gatctgtgag tggaaaaggt tgcttggacc cgcaaactct      600

gggctatcac ggacagatgc ccccggaagc atccgagccc tctttgggac agatggcgtg      660

agaaatgcag ctcacggccc tgatactttt gcatctgctg ccagagaaat ggaattgttt      720

tttccttcaa gtggaggctg tgggccagcg aacactgcta aatttaccaa ttgcacctgt      780

tgcatcatta agcctcatgc tatcagtgaa gatttattta ttcattatat gtaa            834


<210>  39
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse NM23-H7-2

<400>  39

Met Arg Ala Cys Gln Gln Gly Arg Ser Ser Ser Leu Val Ser Pro Tyr 
1               5                   10                  15      


Met Ala Pro Lys Asn Gln Ser Glu Arg Phe Ala Phe Ile Ala Glu Trp 
            20                  25                  30          


Tyr Asp Pro Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe Tyr 
        35                  40                  45              


Pro Thr Asp Gly Ser Val Glu Met His Asp Val Lys Asn Arg Arg Thr 
    50                  55                  60                  


Phe Leu Lys Arg Thr Lys Tyr Glu Asp Leu Arg Leu Glu Asp Leu Phe 
65                  70                  75                  80  


Ile Gly Asn Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile Asp 
                85                  90                  95      


Tyr Gly Asp Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu Lys 
            100                 105                 110         


Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ser Lys Ala Gly Glu Ile 
        115                 120                 125             


Ile Glu Met Ile Asn Lys Ser Gly Phe Thr Ile Thr Lys Leu Arg Met 
    130                 135                 140                 


Met Thr Leu Thr Arg Lys Glu Ala Ala Asp Phe His Val Asp His His 
145                 150                 155                 160 


Ser Arg Pro Phe Tyr Asn Glu Leu Ile Gln Phe Ile Thr Ser Gly Pro 
                165                 170                 175     


Val Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys 
            180                 185                 190         


Arg Leu Leu Gly Pro Ala Asn Ser Gly Leu Ser Arg Thr Asp Ala Pro 
        195                 200                 205             


Gly Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Val Arg Asn Ala Ala 
    210                 215                 220                 


His Gly Pro Asp Thr Phe Ala Ser Ala Ala Arg Glu Met Glu Leu Phe 
225                 230                 235                 240 


Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr 
                245                 250                 255     


Asn Cys Thr Cys Cys Ile Ile Lys Pro His Ala Ile Ser Glu Asp Leu 
            260                 265                 270         


Phe Ile His Tyr Met 
        275         


<210>  40
<211>  1761
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse NME8 variant1

<400>  40
atggcaagca aaaagcgtga agtccagcta cagtcagtcg tcaatagtca gaacttgtgg       60

gatgagatgt tgctgaacaa aggcttaaca gtgattgatg tttaccaagc ctggtgtgga      120

ccttgcaaag ccgtgcaaag tttattcaga aaactaaaaa atgaactgaa cgaagatgag      180

attcttcact tcgtcgttgc tgaagctgac aacattgtga ctctccagcc atttagagat      240

aaatgtgagc ccgtgtttct ctttagtctt aatggtaaaa tcattgcaaa gattcagggt      300

gcaaatgctc cacttatcaa tagaaaagtc attaccttga tagatgaaga gaggaaaatt      360

gtagcaggtg aaatggatcg tcctcagtat gttgaaattc cactagtaga tgcaatcgat      420

gaagaatatg gggaagtaca gtatgaaagt gctgcggaag tttacaatat ggcaattatc      480

aaacctgatg ctgtactcat gagaaaaaat atagaagtta gggaaaaaat agccaaagaa      540

ggatttgtta tagaaataca agaaaacctg attctccctg aagaggtagt gagggaattc      600

tacactcata tagcagacca gcctgacttt gaagagtttg tcgtttctat gacaaatggc      660

ctcagctgtg tgctcattgt atctcaagaa gactccgagg ttattcagga agaaactctc      720

ccgcagactg atacagaaga agaacctggc gttttggaag agcctcacgt taggtttgca      780

cctgtgatga taaagaagaa acgggacagt ttgcaagagt atatggaccg acagcatatg      840

tctgattact gcgatgtcga ggacgatgcg gttaaggtct ctaagctcat tgacatatta      900

ttccctgatt ttaaaactat gaaaagcacg aatgtacaaa cgacgctagc attactgcat      960

ccagacatct gtgaggaaga gaaagatgac gtgttgaacg ttattcacaa tgaagggttc     1020

accatactga tgcagaggca aatcgtatta tcagaggaag aagcaagaac agtgtgcaag     1080

atccatgaaa acgaagagta ttttgataat cttatagggc acatgaccag taatcactct     1140

tatgtccttg ctctacggag ggaaaatggt gtggaatatt ggaaaacatt aattgggcca     1200

aaaacgattg aggaagctta tgcatctcat ccacagagtt tatgtgtaca gtttgcttca     1260

gggaattttc ctaccaacca gttctacggg agcagttcaa aagcagcagc tgagaaggaa     1320

atagcgcatt tcttccctcc ccagagcaca cttgcattga tcaagcctca tgtgacacac     1380

aaagaaagaa tggagatcct gaagaccatt aaagaggcag gatttgagct gaccctgatg     1440

aaggaaatgc acctgactcc agagcatgca aacaaaattt atttcaaaat aacaggaaaa     1500

gatttttata aaaatgtatt ggaagtctta tctttgggca tgtcgctagt catggttttg     1560

accaagtgga atgctgttgc agaatggagg cgaatggttg gcccagtaga cccagaagaa     1620

gcaaaactgc tctccccaga atccctccga gccaaatatg gactagacat tttgagaaat     1680

gctgtccatg gggcgtctaa cttttctgaa gcatcagaaa tcattagtaa tgtgttcaca     1740

gagggtaatc ctgagaacta g                                               1761


<210>  41
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse NME8 variant1

<400>  41

Met Ala Ser Lys Lys Arg Glu Val Gln Leu Gln Ser Val Val Asn Ser 
1               5                   10                  15      


Gln Asn Leu Trp Asp Glu Met Leu Leu Asn Lys Gly Leu Thr Val Ile 
            20                  25                  30          


Asp Val Tyr Gln Ala Trp Cys Gly Pro Cys Lys Ala Val Gln Ser Leu 
        35                  40                  45              


Phe Arg Lys Leu Lys Asn Glu Leu Asn Glu Asp Glu Ile Leu His Phe 
    50                  55                  60                  


Val Val Ala Glu Ala Asp Asn Ile Val Thr Leu Gln Pro Phe Arg Asp 
65                  70                  75                  80  


Lys Cys Glu Pro Val Phe Leu Phe Ser Leu Asn Gly Lys Ile Ile Ala 
                85                  90                  95      


Lys Ile Gln Gly Ala Asn Ala Pro Leu Ile Asn Arg Lys Val Ile Thr 
            100                 105                 110         


Leu Ile Asp Glu Glu Arg Lys Ile Val Ala Gly Glu Met Asp Arg Pro 
        115                 120                 125             


Gln Tyr Val Glu Ile Pro Leu Val Asp Ala Ile Asp Glu Glu Tyr Gly 
    130                 135                 140                 


Glu Val Gln Tyr Glu Ser Ala Ala Glu Val Tyr Asn Met Ala Ile Ile 
145                 150                 155                 160 


Lys Pro Asp Ala Val Leu Met Arg Lys Asn Ile Glu Val Arg Glu Lys 
                165                 170                 175     


Ile Ala Lys Glu Gly Phe Val Ile Glu Ile Gln Glu Asn Leu Ile Leu 
            180                 185                 190         


Pro Glu Glu Val Val Arg Glu Phe Tyr Thr His Ile Ala Asp Gln Pro 
        195                 200                 205             


Asp Phe Glu Glu Phe Val Val Ser Met Thr Asn Gly Leu Ser Cys Val 
    210                 215                 220                 


Leu Ile Val Ser Gln Glu Asp Ser Glu Val Ile Gln Glu Glu Thr Leu 
225                 230                 235                 240 


Pro Gln Thr Asp Thr Glu Glu Glu Pro Gly Val Leu Glu Glu Pro His 
                245                 250                 255     


Val Arg Phe Ala Pro Val Met Ile Lys Lys Lys Arg Asp Ser Leu Gln 
            260                 265                 270         


Glu Tyr Met Asp Arg Gln His Met Ser Asp Tyr Cys Asp Val Glu Asp 
        275                 280                 285             


Asp Ala Val Lys Val Ser Lys Leu Ile Asp Ile Leu Phe Pro Asp Phe 
    290                 295                 300                 


Lys Thr Met Lys Ser Thr Asn Val Gln Thr Thr Leu Ala Leu Leu His 
305                 310                 315                 320 


Pro Asp Ile Cys Glu Glu Glu Lys Asp Asp Val Leu Asn Val Ile His 
                325                 330                 335     


Asn Glu Gly Phe Thr Ile Leu Met Gln Arg Gln Ile Val Leu Ser Glu 
            340                 345                 350         


Glu Glu Ala Arg Thr Val Cys Lys Ile His Glu Asn Glu Glu Tyr Phe 
        355                 360                 365             


Asp Asn Leu Ile Gly His Met Thr Ser Asn His Ser Tyr Val Leu Ala 
    370                 375                 380                 


Leu Arg Arg Glu Asn Gly Val Glu Tyr Trp Lys Thr Leu Ile Gly Pro 
385                 390                 395                 400 


Lys Thr Ile Glu Glu Ala Tyr Ala Ser His Pro Gln Ser Leu Cys Val 
                405                 410                 415     


Gln Phe Ala Ser Gly Asn Phe Pro Thr Asn Gln Phe Tyr Gly Ser Ser 
            420                 425                 430         


Ser Lys Ala Ala Ala Glu Lys Glu Ile Ala His Phe Phe Pro Pro Gln 
        435                 440                 445             


Ser Thr Leu Ala Leu Ile Lys Pro His Val Thr His Lys Glu Arg Met 
    450                 455                 460                 


Glu Ile Leu Lys Thr Ile Lys Glu Ala Gly Phe Glu Leu Thr Leu Met 
465                 470                 475                 480 


Lys Glu Met His Leu Thr Pro Glu His Ala Asn Lys Ile Tyr Phe Lys 
                485                 490                 495     


Ile Thr Gly Lys Asp Phe Tyr Lys Asn Val Leu Glu Val Leu Ser Leu 
            500                 505                 510         


Gly Met Ser Leu Val Met Val Leu Thr Lys Trp Asn Ala Val Ala Glu 
        515                 520                 525             


Trp Arg Arg Met Val Gly Pro Val Asp Pro Glu Glu Ala Lys Leu Leu 
    530                 535                 540                 


Ser Pro Glu Ser Leu Arg Ala Lys Tyr Gly Leu Asp Ile Leu Arg Asn 
545                 550                 555                 560 


Ala Val His Gly Ala Ser Asn Phe Ser Glu Ala Ser Glu Ile Ile Ser 
                565                 570                 575     


Asn Val Phe Thr Glu Gly Asn Pro Glu Asn 
            580                 585     


<210>  42
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse NME8 variant2

<400>  42
atggcaagca aaaagcgtga agtccagcta cagtcagtcg tcaatagtca gaacttgtgg       60

gatgagatgt tgctgaacaa aggcttaaca gtgattgatg tttaccaagc ctggtgtgga      120

ccttgcaaag ccgtgcaaag tttattcaga aaactaaaaa atgaactgaa cgaagatgag      180

attcttcact tcgtcgttgc tgaagctgac aacattgtga ctctccagcc atttagagat      240

aaatgtgagc ccgtgtttct ctttagtctt aatggtaaaa tcattgcaaa gattcagggt      300

gcaaatgctc cacttatcaa tagaaaagtc attaccttga tagatgaaga gaggaaaatt      360

gtagcaggtg aaatggatcg tcctcagtat gttgaaattc cactagtaga tgcaatcgat      420

gaagaatatg gggaagtaca gtatgaaagt gctgcggaag tttacaatat ggcaattatc      480

aaacctgatg ctgtactcat gagaaaaaat atagaagtta gggaaaaaat agccaaagaa      540

ggatttgtta tagaaataca agaaaacctg attctccctg aagaggtagt gagggaattc      600

tacactcata tagcagacca gcctgacttt gaagagtttg tcgtttctat gacaaatggc      660

ctcagctgtg tgctcattgt atctcaagaa gactccgagg ttattcagga agaaactctc      720

ccgcagactg atacagaaga agaacctggc gttttggaag agcctcacgt taggtttgca      780

cctgtgatga taaagaagaa acgggacagt ttgcaagagt atatggaccg acagcatatg      840

tctgattact gcgatgtcga ggacgatgcg gttaaggtct ctaagctcat tgacatatta      900

ttccctgatt ttaaaactat gaaaagcacg aatgtacaaa cgacgctagc attactgcat      960

ccagacatct gtgaggaaga gaaagatgac gtgttgaacg ttattcacaa tgaagggttc     1020

accatactga tgcagaggca aatcgtatta tcagaggaag aagcaagaac agtgtgcaag     1080

atccatgaaa acgaagagta ttttgataat cttatagggc acatgaccag taatcactct     1140

tatgtccttg ctctacggag ggaaaatggt gtggaatatt ggaaaacatt aattgggcca     1200

aaaacgattg aggaagctta tgcatctcat ccacagagtt tatgtgtaca gtttgcttca     1260

gggaattttc ctaccaacca gttctacggg agcagttcaa aagcagcagc tgagaaggaa     1320

atagcgcatt tcttccctcc ccagagcaca cttgcattga tcaagcctca tgtgacacac     1380

aaagaaagaa ttcacagaag ctcaaggagg taatga                               1416


<210>  43
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse NME8 variant2

<400>  43

Met Ala Ser Lys Lys Arg Glu Val Gln Leu Gln Ser Val Val Asn Ser 
1               5                   10                  15      


Gln Asn Leu Trp Asp Glu Met Leu Leu Asn Lys Gly Leu Thr Val Ile 
            20                  25                  30          


Asp Val Tyr Gln Ala Trp Cys Gly Pro Cys Lys Ala Val Gln Ser Leu 
        35                  40                  45              


Phe Arg Lys Leu Lys Asn Glu Leu Asn Glu Asp Glu Ile Leu His Phe 
    50                  55                  60                  


Val Val Ala Glu Ala Asp Asn Ile Val Thr Leu Gln Pro Phe Arg Asp 
65                  70                  75                  80  


Lys Cys Glu Pro Val Phe Leu Phe Ser Leu Asn Gly Lys Ile Ile Ala 
                85                  90                  95      


Lys Ile Gln Gly Ala Asn Ala Pro Leu Ile Asn Arg Lys Val Ile Thr 
            100                 105                 110         


Leu Ile Asp Glu Glu Arg Lys Ile Val Ala Gly Glu Met Asp Arg Pro 
        115                 120                 125             


Gln Tyr Val Glu Ile Pro Leu Val Asp Ala Ile Asp Glu Glu Tyr Gly 
    130                 135                 140                 


Glu Val Gln Tyr Glu Ser Ala Ala Glu Val Tyr Asn Met Ala Ile Ile 
145                 150                 155                 160 


Lys Pro Asp Ala Val Leu Met Arg Lys Asn Ile Glu Val Arg Glu Lys 
                165                 170                 175     


Ile Ala Lys Glu Gly Phe Val Ile Glu Ile Gln Glu Asn Leu Ile Leu 
            180                 185                 190         


Pro Glu Glu Val Val Arg Glu Phe Tyr Thr His Ile Ala Asp Gln Pro 
        195                 200                 205             


Asp Phe Glu Glu Phe Val Val Ser Met Thr Asn Gly Leu Ser Cys Val 
    210                 215                 220                 


Leu Ile Val Ser Gln Glu Asp Ser Glu Val Ile Gln Glu Glu Thr Leu 
225                 230                 235                 240 


Pro Gln Thr Asp Thr Glu Glu Glu Pro Gly Val Leu Glu Glu Pro His 
                245                 250                 255     


Val Arg Phe Ala Pro Val Met Ile Lys Lys Lys Arg Asp Ser Leu Gln 
            260                 265                 270         


Glu Tyr Met Asp Arg Gln His Met Ser Asp Tyr Cys Asp Val Glu Asp 
        275                 280                 285             


Asp Ala Val Lys Val Ser Lys Leu Ile Asp Ile Leu Phe Pro Asp Phe 
    290                 295                 300                 


Lys Thr Met Lys Ser Thr Asn Val Gln Thr Thr Leu Ala Leu Leu His 
305                 310                 315                 320 


Pro Asp Ile Cys Glu Glu Glu Lys Asp Asp Val Leu Asn Val Ile His 
                325                 330                 335     


Asn Glu Gly Phe Thr Ile Leu Met Gln Arg Gln Ile Val Leu Ser Glu 
            340                 345                 350         


Glu Glu Ala Arg Thr Val Cys Lys Ile His Glu Asn Glu Glu Tyr Phe 
        355                 360                 365             


Asp Asn Leu Ile Gly His Met Thr Ser Asn His Ser Tyr Val Leu Ala 
    370                 375                 380                 


Leu Arg Arg Glu Asn Gly Val Glu Tyr Trp Lys Thr Leu Ile Gly Pro 
385                 390                 395                 400 


Lys Thr Ile Glu Glu Ala Tyr Ala Ser His Pro Gln Ser Leu Cys Val 
                405                 410                 415     


Gln Phe Ala Ser Gly Asn Phe Pro Thr Asn Gln Phe Tyr Gly Ser Ser 
            420                 425                 430         


Ser Lys Ala Ala Ala Glu Lys Glu Ile Ala His Phe Phe Pro Pro Gln 
        435                 440                 445             


Ser Thr Leu Ala Leu Ile Lys Pro His Val Thr His Lys Glu Arg Ile 
    450                 455                 460                 


His Arg Ser Ser Arg Arg 
465                 470 


<210>  44
<211>  1767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME8

<400>  44
atggcaagca aaaaacgaga agtccagtta cagacagtca tcaataatca aagcctgtgg       60

gatgagatgt tgcagaacaa aggcttaaca gtgattgatg tttaccaagc ctggtgtgga      120

ccttgcagag caatgcaacc tttattcaga aaattgaaaa atgaactgaa cgaagacgaa      180

attctgcatt ttgctgtcgc agaagctgac aacattgtga ctttgcagcc atttagagat      240

aaatgtgaac ctgtttttct ctttagtgtt aatggcaaaa ttatcgaaaa gattcagggt      300

gcaaatgcac cgcttgttaa taaaaaagtt attaatttga tcgatgagga gagaaaaatt      360

gcagcaggtg aaatggctcg acctcagtat cctgaaattc cattagtaga ctcagattca      420

gaagttagtg aagaatcacc atgtgaaagt gttcaggaat tatacagtat tgctattatc      480

aaaccggatg ctgtgattag taaaaaagtt ctagaaatta aaagaaaaat taccaaagct      540

ggatttatta tagaagcaga gcataagaca gtgctcactg aagaacaagt tgtcaacttc      600

tatagtcgaa tagcagacca gcgtgacttc gaagagtttg tctcttttat gacaagtggc      660

ttaagctata ttctagttgt atctcaagga agtaaacaca atcctccctc tgaagaaacc      720

gaaccacaga ctgacaccga acctaacgaa cgatctgagg atcaacctga ggtcgaagcc      780

caggttacac ctggaatgat gaagaacaaa caagacagtt tacaagaata tctggaaaga      840

caacatttag ctcagctctg tgacattgaa gaggatgcag ctaatgttgc taagttcatg      900

gatgctttct tccccgattt taaaaaaatg aaaagcatga aattagaaaa gacattggca      960

ttacttcgac caaatctctt tcatgaaagg aaagatgatg ttttgcgtat tattaaagat     1020

gaagacttca aaatactgga gcaaagacaa gtagtattat cggaaaaaga agcacaagca     1080

ctgtgcaagg aatatgaaaa tgaagactat tttaataaac ttatagaaaa catgaccagt     1140

ggtccatctc tagcccttgt tttattgaga gacaatggct tgcaatactg gaaacaatta     1200

ctgggaccaa gaactgttga agaagccatt gaatattttc cagagagttt atgtgcacag     1260

tttgcgatgg acagtttgcc ggtcaaccag ttgtatggca gcgattcatt agaaaccgct     1320

gaaagggaaa tacagcattt ctttcctctt caaagcactt taggcttgat taaacctcat     1380

gcaacaagtg aacaaagaga gcagatcctg aagatagtta aggaggctgg atttgatctg     1440

acacaggtga agaaaatgtt cctaactcct gagcaaacgg agaaaattta tccaaaagta     1500

acaggaaaag acttttataa agatttattg gaaatgttat ctgtgggtcc atctatggtc     1560

atgattctga ccaagtggaa tgctgttgca gaatggagac gattgatggg cccaacagac     1620

ccagaagaag caaaattact ttcccctgac tccatccgag cccagtttgg aataagtaaa     1680

ttgaaaaaca ttgtccatgg agcatctaac gcctatgaag caaaagaggt tgttaataga     1740

ctctttgagg atcctgagga aaactaa                                         1767


<210>  45
<211>  588
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME8

<400>  45

Met Ala Ser Lys Lys Arg Glu Val Gln Leu Gln Thr Val Ile Asn Asn 
1               5                   10                  15      


Gln Ser Leu Trp Asp Glu Met Leu Gln Asn Lys Gly Leu Thr Val Ile 
            20                  25                  30          


Asp Val Tyr Gln Ala Trp Cys Gly Pro Cys Arg Ala Met Gln Pro Leu 
        35                  40                  45              


Phe Arg Lys Leu Lys Asn Glu Leu Asn Glu Asp Glu Ile Leu His Phe 
    50                  55                  60                  


Ala Val Ala Glu Ala Asp Asn Ile Val Thr Leu Gln Pro Phe Arg Asp 
65                  70                  75                  80  


Lys Cys Glu Pro Val Phe Leu Phe Ser Val Asn Gly Lys Ile Ile Glu 
                85                  90                  95      


Lys Ile Gln Gly Ala Asn Ala Pro Leu Val Asn Lys Lys Val Ile Asn 
            100                 105                 110         


Leu Ile Asp Glu Glu Arg Lys Ile Ala Ala Gly Glu Met Ala Arg Pro 
        115                 120                 125             


Gln Tyr Pro Glu Ile Pro Leu Val Asp Ser Asp Ser Glu Val Ser Glu 
    130                 135                 140                 


Glu Ser Pro Cys Glu Ser Val Gln Glu Leu Tyr Ser Ile Ala Ile Ile 
145                 150                 155                 160 


Lys Pro Asp Ala Val Ile Ser Lys Lys Val Leu Glu Ile Lys Arg Lys 
                165                 170                 175     


Ile Thr Lys Ala Gly Phe Ile Ile Glu Ala Glu His Lys Thr Val Leu 
            180                 185                 190         


Thr Glu Glu Gln Val Val Asn Phe Tyr Ser Arg Ile Ala Asp Gln Arg 
        195                 200                 205             


Asp Phe Glu Glu Phe Val Ser Phe Met Thr Ser Gly Leu Ser Tyr Ile 
    210                 215                 220                 


Leu Val Val Ser Gln Gly Ser Lys His Asn Pro Pro Ser Glu Glu Thr 
225                 230                 235                 240 


Glu Pro Gln Thr Asp Thr Glu Pro Asn Glu Arg Ser Glu Asp Gln Pro 
                245                 250                 255     


Glu Val Glu Ala Gln Val Thr Pro Gly Met Met Lys Asn Lys Gln Asp 
            260                 265                 270         


Ser Leu Gln Glu Tyr Leu Glu Arg Gln His Leu Ala Gln Leu Cys Asp 
        275                 280                 285             


Ile Glu Glu Asp Ala Ala Asn Val Ala Lys Phe Met Asp Ala Phe Phe 
    290                 295                 300                 


Pro Asp Phe Lys Lys Met Lys Ser Met Lys Leu Glu Lys Thr Leu Ala 
305                 310                 315                 320 


Leu Leu Arg Pro Asn Leu Phe His Glu Arg Lys Asp Asp Val Leu Arg 
                325                 330                 335     


Ile Ile Lys Asp Glu Asp Phe Lys Ile Leu Glu Gln Arg Gln Val Val 
            340                 345                 350         


Leu Ser Glu Lys Glu Ala Gln Ala Leu Cys Lys Glu Tyr Glu Asn Glu 
        355                 360                 365             


Asp Tyr Phe Asn Lys Leu Ile Glu Asn Met Thr Ser Gly Pro Ser Leu 
    370                 375                 380                 


Ala Leu Val Leu Leu Arg Asp Asn Gly Leu Gln Tyr Trp Lys Gln Leu 
385                 390                 395                 400 


Leu Gly Pro Arg Thr Val Glu Glu Ala Ile Glu Tyr Phe Pro Glu Ser 
                405                 410                 415     


Leu Cys Ala Gln Phe Ala Met Asp Ser Leu Pro Val Asn Gln Leu Tyr 
            420                 425                 430         


Gly Ser Asp Ser Leu Glu Thr Ala Glu Arg Glu Ile Gln His Phe Phe 
        435                 440                 445             


Pro Leu Gln Ser Thr Leu Gly Leu Ile Lys Pro His Ala Thr Ser Glu 
    450                 455                 460                 


Gln Arg Glu Gln Ile Leu Lys Ile Val Lys Glu Ala Gly Phe Asp Leu 
465                 470                 475                 480 


Thr Gln Val Lys Lys Met Phe Leu Thr Pro Glu Gln Thr Glu Lys Ile 
                485                 490                 495     


Tyr Pro Lys Val Thr Gly Lys Asp Phe Tyr Lys Asp Leu Leu Glu Met 
            500                 505                 510         


Leu Ser Val Gly Pro Ser Met Val Met Ile Leu Thr Lys Trp Asn Ala 
        515                 520                 525             


Val Ala Glu Trp Arg Arg Leu Met Gly Pro Thr Asp Pro Glu Glu Ala 
    530                 535                 540                 


Lys Leu Leu Ser Pro Asp Ser Ile Arg Ala Gln Phe Gly Ile Ser Lys 
545                 550                 555                 560 


Leu Lys Asn Ile Val His Gly Ala Ser Asn Ala Tyr Glu Ala Lys Glu 
                565                 570                 575     


Val Val Asn Arg Leu Phe Glu Asp Pro Glu Glu Asn 
            580                 585             


<210>  46
<211>  1458
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NME8 E. coli optimized

<400>  46
atgctggtca ataaaaaagt catcaacctg atcgacgaag aacgcaaaat cgccgctggt       60

gaaatggcac gcccgcaata cccggaaatc ccgctggttg atagcgactc tgaagtttca      120

gaagaatcgc cgtgcgaatc agtgcaggaa ctgtattcga tcgcaattat caaaccggat      180

gctgtcattt ccaaaaaagt gctggaaatc aaacgtaaaa tcaccaaagc gggtttcatt      240

atcgaagccg aacataaaac cgtgctgacg gaagaacagg tggttaattt ttattcacgt      300

atcgcggatc agcgcgactt tgaagaattt gtttcgttta tgaccagcgg cctgtcttac      360

attctggtcg tgagtcaggg ttccaaacac aatccgccga gcgaagaaac ggaaccgcag      420

accgatacgg aaccgaacga acgttctgaa gaccagccgg aagtggaagc acaagttacc      480

ccgggcatga tgaaaaataa acaggatagt ctgcaagaat acctggaacg ccagcatctg      540

gctcaactgt gtgatatcga agaagacgcg gccaacgtgg cgaaattcat ggatgccttt      600

ttcccggact tcaagaaaat gaaaagcatg aaactggaaa aaaccctggc cctgctgcgt      660

ccgaacctgt tccacgaacg taaagatgac gttctgcgca tcatcaaaga tgaagacttc      720

aaaatcctgg aacagcgcca agttgtcctg tctgaaaaag aagcacaggc tctgtgcaaa      780

gaatacgaaa acgaagatta cttcaacaaa ctgatcgaaa acatgacctc aggtccgtcg      840

ctggcactgg ttctgctgcg tgataatggc ctgcagtatt ggaaacaact gctgggtccg      900

cgcacggtcg aagaagccat tgaatacttc ccggaaagcc tgtgtgcaca gtttgctatg      960

gattctctgc cggtgaacca actgtatggc agtgactccc tggaaaccgc ggaacgtgaa     1020

atccagcatt tctttccgct gcaaagtacc ctgggtctga ttaaaccgca cgcgacgtcc     1080

gaacagcgcg aacaaattct gaaaatcgtc aaagaagccg gcttcgatct gacccaggtg     1140

aagaaaatgt ttctgacccc ggaacaaacg gaaaaaatct atccgaaagt cacgggcaaa     1200

gatttctaca aagacctgct ggaaatgctg agtgttggtc cgtccatggt catgattctg     1260

accaaatgga atgcggttgc agaatggcgt cgcctgatgg gtccgacgga tccggaagaa     1320

gcaaaactgc tgagcccgga ctctattcgc gctcagtttg gcatcagcaa actgaaaaac     1380

attgttcatg gtgcgtccaa tgcgtatgaa gcgaaagaag ttgtgaaccg cctgtttgaa     1440

gacccggaag aaaattaa                                                   1458


<210>  47
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8 E. coli optimized

<400>  47

Met Leu Val Asn Lys Lys Val Ile Asn Leu Ile Asp Glu Glu Arg Lys 
1               5                   10                  15      


Ile Ala Ala Gly Glu Met Ala Arg Pro Gln Tyr Pro Glu Ile Pro Leu 
            20                  25                  30          


Val Asp Ser Asp Ser Glu Val Ser Glu Glu Ser Pro Cys Glu Ser Val 
        35                  40                  45              


Gln Glu Leu Tyr Ser Ile Ala Ile Ile Lys Pro Asp Ala Val Ile Ser 
    50                  55                  60                  


Lys Lys Val Leu Glu Ile Lys Arg Lys Ile Thr Lys Ala Gly Phe Ile 
65                  70                  75                  80  


Ile Glu Ala Glu His Lys Thr Val Leu Thr Glu Glu Gln Val Val Asn 
                85                  90                  95      


Phe Tyr Ser Arg Ile Ala Asp Gln Arg Asp Phe Glu Glu Phe Val Ser 
            100                 105                 110         


Phe Met Thr Ser Gly Leu Ser Tyr Ile Leu Val Val Ser Gln Gly Ser 
        115                 120                 125             


Lys His Asn Pro Pro Ser Glu Glu Thr Glu Pro Gln Thr Asp Thr Glu 
    130                 135                 140                 


Pro Asn Glu Arg Ser Glu Asp Gln Pro Glu Val Glu Ala Gln Val Thr 
145                 150                 155                 160 


Pro Gly Met Met Lys Asn Lys Gln Asp Ser Leu Gln Glu Tyr Leu Glu 
                165                 170                 175     


Arg Gln His Leu Ala Gln Leu Cys Asp Ile Glu Glu Asp Ala Ala Asn 
            180                 185                 190         


Val Ala Lys Phe Met Asp Ala Phe Phe Pro Asp Phe Lys Lys Met Lys 
        195                 200                 205             


Ser Met Lys Leu Glu Lys Thr Leu Ala Leu Leu Arg Pro Asn Leu Phe 
    210                 215                 220                 


His Glu Arg Lys Asp Asp Val Leu Arg Ile Ile Lys Asp Glu Asp Phe 
225                 230                 235                 240 


Lys Ile Leu Glu Gln Arg Gln Val Val Leu Ser Glu Lys Glu Ala Gln 
                245                 250                 255     


Ala Leu Cys Lys Glu Tyr Glu Asn Glu Asp Tyr Phe Asn Lys Leu Ile 
            260                 265                 270         


Glu Asn Met Thr Ser Gly Pro Ser Leu Ala Leu Val Leu Leu Arg Asp 
        275                 280                 285             


Asn Gly Leu Gln Tyr Trp Lys Gln Leu Leu Gly Pro Arg Thr Val Glu 
    290                 295                 300                 


Glu Ala Ile Glu Tyr Phe Pro Glu Ser Leu Cys Ala Gln Phe Ala Met 
305                 310                 315                 320 


Asp Ser Leu Pro Val Asn Gln Leu Tyr Gly Ser Asp Ser Leu Glu Thr 
                325                 330                 335     


Ala Glu Arg Glu Ile Gln His Phe Phe Pro Leu Gln Ser Thr Leu Gly 
            340                 345                 350         


Leu Ile Lys Pro His Ala Thr Ser Glu Gln Arg Glu Gln Ile Leu Lys 
        355                 360                 365             


Ile Val Lys Glu Ala Gly Phe Asp Leu Thr Gln Val Lys Lys Met Phe 
    370                 375                 380                 


Leu Thr Pro Glu Gln Thr Glu Lys Ile Tyr Pro Lys Val Thr Gly Lys 
385                 390                 395                 400 


Asp Phe Tyr Lys Asp Leu Leu Glu Met Leu Ser Val Gly Pro Ser Met 
                405                 410                 415     


Val Met Ile Leu Thr Lys Trp Asn Ala Val Ala Glu Trp Arg Arg Leu 
            420                 425                 430         


Met Gly Pro Thr Asp Pro Glu Glu Ala Lys Leu Leu Ser Pro Asp Ser 
        435                 440                 445             


Ile Arg Ala Gln Phe Gly Ile Ser Lys Leu Lys Asn Ile Val His Gly 
    450                 455                 460                 


Ala Ser Asn Ala Tyr Glu Ala Lys Glu Val Val Asn Arg Leu Phe Glu 
465                 470                 475                 480 


Asp Pro Glu Glu Asn 
                485 


<210>  48
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NME8 1-2 E. coli optimized

<400>  48
atgctggtca ataaaaaagt catcaacctg atcgacgaag aacgcaaaat cgccgctggt       60

gaaatggcac gcccgcaata cccggaaatc ccgctggttg atagcgactc tgaagtttca      120

gaagaatcgc cgtgcgaatc agtgcaggaa ctgtattcga tcgcaattat caaaccggat      180

gctgtcattt ccaaaaaagt gctggaaatc aaacgtaaaa tcaccaaagc gggtttcatt      240

atcgaagccg aacataaaac cgtgctgacg gaagaacagg tggttaattt ttattcacgt      300

atcgcggatc agcgcgactt tgaagaattt gtttcgttta tgaccagcgg cctgtcttac      360

attctggtcg tgagtcaggg ttccaaacac aatccgccga gcgaagaaac ggaaccgcag      420

accgatacgg aaccgaacga acgttctgaa gaccagccgg aagtggaagc acaagttacc      480

ccgggcatga tgaaaaataa acaggatagt ctgcaagaat acctggaacg ccagcatctg      540

gctcaactgt gtgatatcga agaagacgcg gccaacgtgg cgaaattcat ggatgccttt      600

ttcccggact tcaagaaaat gaaaagcatg aaactggaaa aaaccctggc cctgctgcgt      660

ccgaacctgt tccacgaacg taaagatgac gttctgcgca tcatcaaaga tgaagacttc      720

aaaatcctgg aacagcgcca agttgtcctg tctgaaaaag aagcacaggc tctgtgcaaa      780

gaatacgaaa acgaagatta cttcaacaaa ctgatcgaaa acatgacctc aggtccgtcg      840

ctggcactgg ttctgctgcg tgataatggc ctgcagtatt ggaaacaact gctgggtccg      900

cgcacggtcg aagaagccat tgaatacttc ccggaaagcc tgtgtgcaca gtttgctatg      960

gattctctgc cggtgaacca actgtatggc agtgactccc tggaaaccgc ggaacgtgaa     1020

atccagcatt tctttctcga gcaccaccac caccaccact ga                        1062


<210>  49
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8 1-2 E. coli optimized

<400>  49

Met Leu Val Asn Lys Lys Val Ile Asn Leu Ile Asp Glu Glu Arg Lys 
1               5                   10                  15      


Ile Ala Ala Gly Glu Met Ala Arg Pro Gln Tyr Pro Glu Ile Pro Leu 
            20                  25                  30          


Val Asp Ser Asp Ser Glu Val Ser Glu Glu Ser Pro Cys Glu Ser Val 
        35                  40                  45              


Gln Glu Leu Tyr Ser Ile Ala Ile Ile Lys Pro Asp Ala Val Ile Ser 
    50                  55                  60                  


Lys Lys Val Leu Glu Ile Lys Arg Lys Ile Thr Lys Ala Gly Phe Ile 
65                  70                  75                  80  


Ile Glu Ala Glu His Lys Thr Val Leu Thr Glu Glu Gln Val Val Asn 
                85                  90                  95      


Phe Tyr Ser Arg Ile Ala Asp Gln Arg Asp Phe Glu Glu Phe Val Ser 
            100                 105                 110         


Phe Met Thr Ser Gly Leu Ser Tyr Ile Leu Val Val Ser Gln Gly Ser 
        115                 120                 125             


Lys His Asn Pro Pro Ser Glu Glu Thr Glu Pro Gln Thr Asp Thr Glu 
    130                 135                 140                 


Pro Asn Glu Arg Ser Glu Asp Gln Pro Glu Val Glu Ala Gln Val Thr 
145                 150                 155                 160 


Pro Gly Met Met Lys Asn Lys Gln Asp Ser Leu Gln Glu Tyr Leu Glu 
                165                 170                 175     


Arg Gln His Leu Ala Gln Leu Cys Asp Ile Glu Glu Asp Ala Ala Asn 
            180                 185                 190         


Val Ala Lys Phe Met Asp Ala Phe Phe Pro Asp Phe Lys Lys Met Lys 
        195                 200                 205             


Ser Met Lys Leu Glu Lys Thr Leu Ala Leu Leu Arg Pro Asn Leu Phe 
    210                 215                 220                 


His Glu Arg Lys Asp Asp Val Leu Arg Ile Ile Lys Asp Glu Asp Phe 
225                 230                 235                 240 


Lys Ile Leu Glu Gln Arg Gln Val Val Leu Ser Glu Lys Glu Ala Gln 
                245                 250                 255     


Ala Leu Cys Lys Glu Tyr Glu Asn Glu Asp Tyr Phe Asn Lys Leu Ile 
            260                 265                 270         


Glu Asn Met Thr Ser Gly Pro Ser Leu Ala Leu Val Leu Leu Arg Asp 
        275                 280                 285             


Asn Gly Leu Gln Tyr Trp Lys Gln Leu Leu Gly Pro Arg Thr Val Glu 
    290                 295                 300                 


Glu Ala Ile Glu Tyr Phe Pro Glu Ser Leu Cys Ala Gln Phe Ala Met 
305                 310                 315                 320 


Asp Ser Leu Pro Val Asn Gln Leu Tyr Gly Ser Asp Ser Leu Glu Thr 
                325                 330                 335     


Ala Glu Arg Glu Ile Gln His Phe Phe Leu Glu His His His His His 
            340                 345                 350         


His 
    


<210>  50
<211>  852
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NME8 2-3 E coli optimized

<400>  50
atgctggaaa aaaccctggc cctgctgcgt ccgaacctgt tccacgaacg taaagatgac       60

gttctgcgca tcatcaaaga tgaagacttc aaaatcctgg aacagcgcca agttgtcctg      120

tctgaaaaag aagcacaggc tctgtgcaaa gaatacgaaa acgaagatta cttcaacaaa      180

ctgatcgaaa acatgacctc aggtccgtcg ctggcactgg ttctgctgcg tgataatggc      240

ctgcagtatt ggaaacaact gctgggtccg cgcacggtcg aagaagccat tgaatacttc      300

ccggaaagcc tgtgtgcaca gtttgctatg gattctctgc cggtgaacca actgtatggc      360

agtgactccc tggaaaccgc ggaacgtgaa atccagcatt tctttccgct gcaaagtacc      420

ctgggtctga ttaaaccgca cgcgacgtcc gaacagcgcg aacaaattct gaaaatcgtc      480

aaagaagccg gcttcgatct gacccaggtg aagaaaatgt ttctgacccc ggaacaaacg      540

gaaaaaatct atccgaaagt cacgggcaaa gatttctaca aagacctgct ggaaatgctg      600

agtgttggtc cgtccatggt catgattctg accaaatgga atgcggttgc agaatggcgt      660

cgcctgatgg gtccgacgga tccggaagaa gcaaaactgc tgagcccgga ctctattcgc      720

gctcagtttg gcatcagcaa actgaaaaac attgttcatg gtgcgtccaa tgcgtatgaa      780

gcgaaagaag ttgtgaaccg cctgtttgaa gacccggaag aaaatctcga gcaccaccac      840

caccaccact ga                                                          852


<210>  51
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8 2-3 E coli optimized

<400>  51

Met Leu Glu Lys Thr Leu Ala Leu Leu Arg Pro Asn Leu Phe His Glu 
1               5                   10                  15      


Arg Lys Asp Asp Val Leu Arg Ile Ile Lys Asp Glu Asp Phe Lys Ile 
            20                  25                  30          


Leu Glu Gln Arg Gln Val Val Leu Ser Glu Lys Glu Ala Gln Ala Leu 
        35                  40                  45              


Cys Lys Glu Tyr Glu Asn Glu Asp Tyr Phe Asn Lys Leu Ile Glu Asn 
    50                  55                  60                  


Met Thr Ser Gly Pro Ser Leu Ala Leu Val Leu Leu Arg Asp Asn Gly 
65                  70                  75                  80  


Leu Gln Tyr Trp Lys Gln Leu Leu Gly Pro Arg Thr Val Glu Glu Ala 
                85                  90                  95      


Ile Glu Tyr Phe Pro Glu Ser Leu Cys Ala Gln Phe Ala Met Asp Ser 
            100                 105                 110         


Leu Pro Val Asn Gln Leu Tyr Gly Ser Asp Ser Leu Glu Thr Ala Glu 
        115                 120                 125             


Arg Glu Ile Gln His Phe Phe Pro Leu Gln Ser Thr Leu Gly Leu Ile 
    130                 135                 140                 


Lys Pro His Ala Thr Ser Glu Gln Arg Glu Gln Ile Leu Lys Ile Val 
145                 150                 155                 160 


Lys Glu Ala Gly Phe Asp Leu Thr Gln Val Lys Lys Met Phe Leu Thr 
                165                 170                 175     


Pro Glu Gln Thr Glu Lys Ile Tyr Pro Lys Val Thr Gly Lys Asp Phe 
            180                 185                 190         


Tyr Lys Asp Leu Leu Glu Met Leu Ser Val Gly Pro Ser Met Val Met 
        195                 200                 205             


Ile Leu Thr Lys Trp Asn Ala Val Ala Glu Trp Arg Arg Leu Met Gly 
    210                 215                 220                 


Pro Thr Asp Pro Glu Glu Ala Lys Leu Leu Ser Pro Asp Ser Ile Arg 
225                 230                 235                 240 


Ala Gln Phe Gly Ile Ser Lys Leu Lys Asn Ile Val His Gly Ala Ser 
                245                 250                 255     


Asn Ala Tyr Glu Ala Lys Glu Val Val Asn Arg Leu Phe Glu Asp Pro 
            260                 265                 270         


Glu Glu Asn Leu Glu His His His His His His 
        275                 280             


