                         SEQUENCE LISTING

<110>  University of Vermont and State Agricultural College
       Francklyn, Christopher
       Lounsbury, Karen M
       Williams, Tamara
 
<120>  METHODS AND COMPOUNDS FOR DIAGNOSING THREONYL-tRNA 
       SYNTHETASE-ASSOCIATED DISEASES AND CONDITIONS

<130>  UVM70106WO

<150>  US 61/675,652
<151>  2012-07-25

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  2888
<212>  DNA
<213>  Homo sapiens

<400>  1
ggtcagcgga gagtaggcat gtagcttctg cagttgctcc tcctcaccct ccgcgacctg       60

atttcctaga agggctctgt cacccgaaaa gattttccac tggcttagag gagggagggc      120

ccgccttccc ccgttatcca ttggctgctc gttccgccgc aagttggggg cggggttagg      180

gcgcctttcg attgcatcag ctggtccagc cgaggccaag tcccgggcgc tagcccacct      240

cccacccgcc tcttggctcc tctcctctag gccgtcgctt tcgggttctc tcatcgcttc      300

gtcgttcgcc aatgtttgag gagaaggcca gcagtccttc agggaagatg ggaggcgagg      360

agaagccgat tggtgctggt gaagagaagc aaaaggaagg aggcaaaaag aagaacaaag      420

aaggatctgg agatggaggt cgagctgagt tgaatccttg gcctgaatat atttacacac      480

gtcttgagat gtataatata ctaaaagcag aacatgattc cattctggca gaaaaggcag      540

aaaaagatag caagccaatt aaagtcactt tgcctgatgg taaacaggtt gatgcggaat      600

cttggaaaac tacaccatat caaattgcct gtggaattag tcaaggcctg gccgacaaca      660

ccgttattgc taaagtaaat aatgttgtgt gggacctgga ccgccctctg gaagaagatt      720

gtaccttgga gcttctcaag tttgaggatg aggaagctca ggcagtgtat tggcactcta      780

gtgctcacat aatgggtgaa gccatggaaa gagtctatgg tggatgttta tgctacggtc      840

cgccaataga aaatggattc tattatgaca tgtacctcga agaagggggt gtgtctagca      900

atgatttctc ttctctggag gctttgtgta agaaaatcat taaagaaaaa caagcttttg      960

aaagactgga agttaagaaa gaaactttac tggcaatgtt taagtacaac aagttcaaat     1020

gccggatatt gaatgaaaag gtgaatactc caactaccac agtctataga tgtggccctt     1080

tgatagatct ctgccggggt cctcatgtta gacacacggg caaaattaag gctttaaaaa     1140

tacacaaaaa ttcctccacg tactgggaag gcaaagcaga tatggagact ctccagagaa     1200

tttatggcat ttcattccca gatcctaaaa tgttgaaaga gtgggagaag ttccaagagg     1260

aagctaaaaa ccgagatcat aggaaaattg gcagggacca agaactatat ttctttcatg     1320

aactcagccc tggaagttgc ttttttctgc caaaaggagc ctacatttat aatgcactta     1380

ttgaattcat taggagcgaa tataggaaaa gaggattcca ggaggtagtc accccaaaca     1440

tcttcaacag ccgactctgg atgacctcgg gccactggca gcactacagc gagaacatgt     1500

tctcctttga ggtggagaag gagctgtttg ccctgaaacc catgaactgc ccaggacact     1560

gccttatgtt tgatcatcgg ccaaggtcct ggcgagaact gcctctgcgg ctagctgatt     1620

ttggggtact tcataggaac gagctgtctg gagcactcac aggactcacc cgggtacgaa     1680

gattccaaca ggatgatgct cacatattct gtgccatgga gcagattgaa gatgaaataa     1740

aaggttgttt ggattttcta cgtacggtat atagcgtatt tggattttct tttaaactaa     1800

acctttctac tcgcccggaa aaattccttg gagatatcga agtatgggat caagctgaga     1860

aacaacttga aaacagtctg aatgaatttg gtgaaaagtg ggagttaaac tctggagatg     1920

gagctttcta tggcccaaag attgacatac agattaaaga tgcgattggg cggtaccacc     1980

agtgtgcaac catccagctg gatttccagt tgcccatcag atttaatctt acttatgtaa     2040

gccatgatgg tgatgataag aaaaggccag tgattgttca tcgagccatc ttgggatcag     2100

tggaaagaat gattgctatc ctcacagaaa actatggggg caaatggccc ttttggctgt     2160

cccctcgcca ggtaatggta gttccagtgg gaccaacctg tgatgaatat gcccaaaagg     2220

tacgacaaca attccacgat gccaaattca tggcagacat tgatctggat ccaggctgta     2280

cattgaataa aaagattcga aatgcacagt tagcacagta taacttcatt ttagttgttg     2340

gtgaaaaaga gaaaatcagt ggcactgtta atatccgcac aagagacaat aaggtccacg     2400

gggaacgcac catttctgaa actatcgagc ggctacagca gctcaaagag ttccgcagca     2460

aacaggcaga agaagaattt taatgaaaaa attacccaga ttggctccat ggaaaaggag     2520

gaacagcgtt tccgtaaaat tgactttgta ctctgaaaac gtcaatttat attgaacttg     2580

gaggagtttg gcaaagtctg aataggtcaa cctgcaggcg taactatttt tgacctagtc     2640

agtttttaaa caatgtgcat ttgaaggagt taattaaaag agagccaata aaatgatttt     2700

actcattcag tatctgagta ctggaagtga aacatgagga atgctttagt gtaatgtggg     2760

agaacttttt tgtaaattta atgcaattga aaaagttttc aaattcaatt aagataacta     2820

gaattggatt atggtgtaaa aataaaaaaa aaatttattc acataaaaaa aaaaaaaaaa     2880

aaaaaaaa                                                              2888


<210>  2
<211>  723
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Phe Glu Glu Lys Ala Ser Ser Pro Ser Gly Lys Met Gly Gly Glu 
1               5                   10                  15      


Glu Lys Pro Ile Gly Ala Gly Glu Glu Lys Gln Lys Glu Gly Gly Lys 
            20                  25                  30          


Lys Lys Asn Lys Glu Gly Ser Gly Asp Gly Gly Arg Ala Glu Leu Asn 
        35                  40                  45              


Pro Trp Pro Glu Tyr Ile Tyr Thr Arg Leu Glu Met Tyr Asn Ile Leu 
    50                  55                  60                  


Lys Ala Glu His Asp Ser Ile Leu Ala Glu Lys Ala Glu Lys Asp Ser 
65                  70                  75                  80  


Lys Pro Ile Lys Val Thr Leu Pro Asp Gly Lys Gln Val Asp Ala Glu 
                85                  90                  95      


Ser Trp Lys Thr Thr Pro Tyr Gln Ile Ala Cys Gly Ile Ser Gln Gly 
            100                 105                 110         


Leu Ala Asp Asn Thr Val Ile Ala Lys Val Asn Asn Val Val Trp Asp 
        115                 120                 125             


Leu Asp Arg Pro Leu Glu Glu Asp Cys Thr Leu Glu Leu Leu Lys Phe 
    130                 135                 140                 


Glu Asp Glu Glu Ala Gln Ala Val Tyr Trp His Ser Ser Ala His Ile 
145                 150                 155                 160 


Met Gly Glu Ala Met Glu Arg Val Tyr Gly Gly Cys Leu Cys Tyr Gly 
                165                 170                 175     


Pro Pro Ile Glu Asn Gly Phe Tyr Tyr Asp Met Tyr Leu Glu Glu Gly 
            180                 185                 190         


Gly Val Ser Ser Asn Asp Phe Ser Ser Leu Glu Ala Leu Cys Lys Lys 
        195                 200                 205             


Ile Ile Lys Glu Lys Gln Ala Phe Glu Arg Leu Glu Val Lys Lys Glu 
    210                 215                 220                 


Thr Leu Leu Ala Met Phe Lys Tyr Asn Lys Phe Lys Cys Arg Ile Leu 
225                 230                 235                 240 


Asn Glu Lys Val Asn Thr Pro Thr Thr Thr Val Tyr Arg Cys Gly Pro 
                245                 250                 255     


Leu Ile Asp Leu Cys Arg Gly Pro His Val Arg His Thr Gly Lys Ile 
            260                 265                 270         


Lys Ala Leu Lys Ile His Lys Asn Ser Ser Thr Tyr Trp Glu Gly Lys 
        275                 280                 285             


Ala Asp Met Glu Thr Leu Gln Arg Ile Tyr Gly Ile Ser Phe Pro Asp 
    290                 295                 300                 


Pro Lys Met Leu Lys Glu Trp Glu Lys Phe Gln Glu Glu Ala Lys Asn 
305                 310                 315                 320 


Arg Asp His Arg Lys Ile Gly Arg Asp Gln Glu Leu Tyr Phe Phe His 
                325                 330                 335     


Glu Leu Ser Pro Gly Ser Cys Phe Phe Leu Pro Lys Gly Ala Tyr Ile 
            340                 345                 350         


Tyr Asn Ala Leu Ile Glu Phe Ile Arg Ser Glu Tyr Arg Lys Arg Gly 
        355                 360                 365             


Phe Gln Glu Val Val Thr Pro Asn Ile Phe Asn Ser Arg Leu Trp Met 
    370                 375                 380                 


Thr Ser Gly His Trp Gln His Tyr Ser Glu Asn Met Phe Ser Phe Glu 
385                 390                 395                 400 


Val Glu Lys Glu Leu Phe Ala Leu Lys Pro Met Asn Cys Pro Gly His 
                405                 410                 415     


Cys Leu Met Phe Asp His Arg Pro Arg Ser Trp Arg Glu Leu Pro Leu 
            420                 425                 430         


Arg Leu Ala Asp Phe Gly Val Leu His Arg Asn Glu Leu Ser Gly Ala 
        435                 440                 445             


Leu Thr Gly Leu Thr Arg Val Arg Arg Phe Gln Gln Asp Asp Ala His 
    450                 455                 460                 


Ile Phe Cys Ala Met Glu Gln Ile Glu Asp Glu Ile Lys Gly Cys Leu 
465                 470                 475                 480 


Asp Phe Leu Arg Thr Val Tyr Ser Val Phe Gly Phe Ser Phe Lys Leu 
                485                 490                 495     


Asn Leu Ser Thr Arg Pro Glu Lys Phe Leu Gly Asp Ile Glu Val Trp 
            500                 505                 510         


Asp Gln Ala Glu Lys Gln Leu Glu Asn Ser Leu Asn Glu Phe Gly Glu 
        515                 520                 525             


Lys Trp Glu Leu Asn Ser Gly Asp Gly Ala Phe Tyr Gly Pro Lys Ile 
    530                 535                 540                 


Asp Ile Gln Ile Lys Asp Ala Ile Gly Arg Tyr His Gln Cys Ala Thr 
545                 550                 555                 560 


Ile Gln Leu Asp Phe Gln Leu Pro Ile Arg Phe Asn Leu Thr Tyr Val 
                565                 570                 575     


Ser His Asp Gly Asp Asp Lys Lys Arg Pro Val Ile Val His Arg Ala 
            580                 585                 590         


Ile Leu Gly Ser Val Glu Arg Met Ile Ala Ile Leu Thr Glu Asn Tyr 
        595                 600                 605             


Gly Gly Lys Trp Pro Phe Trp Leu Ser Pro Arg Gln Val Met Val Val 
    610                 615                 620                 


Pro Val Gly Pro Thr Cys Asp Glu Tyr Ala Gln Lys Val Arg Gln Gln 
625                 630                 635                 640 


Phe His Asp Ala Lys Phe Met Ala Asp Ile Asp Leu Asp Pro Gly Cys 
                645                 650                 655     


Thr Leu Asn Lys Lys Ile Arg Asn Ala Gln Leu Ala Gln Tyr Asn Phe 
            660                 665                 670         


Ile Leu Val Val Gly Glu Lys Glu Lys Ile Ser Gly Thr Val Asn Ile 
        675                 680                 685             


Arg Thr Arg Asp Asn Lys Val His Gly Glu Arg Thr Ile Ser Glu Thr 
    690                 695                 700                 


Ile Glu Arg Leu Gln Gln Leu Lys Glu Phe Arg Ser Lys Gln Ala Glu 
705                 710                 715                 720 


Glu Glu Phe 
            


<210>  3
<211>  722
<212>  PRT
<213>  Mus musculus

<400>  3

Met Ser Gln Glu Lys Ala Ser Ser Pro Ser Gly Lys Met Asp Gly Glu 
1               5                   10                  15      


Lys Pro Val Asp Ala Ser Glu Glu Lys Arg Lys Glu Gly Gly Lys Lys 
            20                  25                  30          


Lys Ser Lys Asp Gly Gly Gly Asp Gly Gly Arg Ala Glu Leu Asn Pro 
        35                  40                  45              


Trp Pro Glu Tyr Ile Asn Thr Arg Leu Asp Met Tyr Asn Lys Leu Lys 
    50                  55                  60                  


Ala Glu His Asp Ser Ile Leu Ala Glu Lys Ala Ala Lys Asp Ser Lys 
65                  70                  75                  80  


Pro Ile Lys Val Thr Leu Pro Asp Gly Lys Gln Val Asp Ala Glu Ser 
                85                  90                  95      


Trp Lys Thr Thr Pro Tyr Gln Ile Ala Cys Gly Ile Ser Gln Gly Leu 
            100                 105                 110         


Ala Asp Asn Thr Val Val Ala Lys Val Asn Lys Val Val Trp Asp Leu 
        115                 120                 125             


Asp Arg Pro Leu Glu Thr Asp Cys Thr Leu Glu Leu Leu Lys Phe Glu 
    130                 135                 140                 


Asp Glu Glu Ala Gln Ala Val Tyr Trp His Ser Ser Ala His Ile Met 
145                 150                 155                 160 


Gly Glu Ala Met Glu Arg Val Tyr Gly Gly Cys Leu Cys Tyr Gly Pro 
                165                 170                 175     


Pro Ile Glu Asn Gly Phe Tyr Tyr Asp Met Tyr Leu Glu Glu Gly Gly 
            180                 185                 190         


Val Ser Ser Asn Asp Phe Ser Ser Leu Glu Thr Leu Cys Lys Lys Ile 
        195                 200                 205             


Ile Lys Glu Lys Gln Thr Phe Glu Arg Leu Glu Val Lys Lys Glu Thr 
    210                 215                 220                 


Leu Leu Glu Met Phe Lys Tyr Asn Lys Phe Lys Cys Arg Ile Leu Asn 
225                 230                 235                 240 


Glu Lys Val Asn Thr Pro Thr Thr Thr Val Tyr Arg Cys Gly Pro Leu 
                245                 250                 255     


Ile Asp Leu Cys Arg Gly Pro His Val Arg His Thr Gly Lys Ile Lys 
            260                 265                 270         


Thr Leu Lys Ile His Lys Asn Ser Ser Thr Tyr Trp Glu Gly Lys Ala 
        275                 280                 285             


Asp Met Glu Thr Leu Gln Arg Ile Tyr Gly Ile Ser Phe Pro Asp Pro 
    290                 295                 300                 


Lys Leu Leu Lys Glu Trp Glu Lys Phe Gln Glu Glu Ala Lys Asn Arg 
305                 310                 315                 320 


Asp His Arg Lys Ile Gly Arg Asp Gln Glu Leu Tyr Phe Phe His Glu 
                325                 330                 335     


Leu Ser Pro Gly Ser Cys Phe Phe Leu Pro Lys Gly Ala Tyr Ile Tyr 
            340                 345                 350         


Asn Thr Leu Met Glu Phe Ile Arg Ser Glu Tyr Arg Lys Arg Gly Phe 
        355                 360                 365             


Gln Glu Val Val Thr Pro Asn Ile Phe Asn Ser Arg Leu Trp Met Thr 
    370                 375                 380                 


Ser Gly His Trp Gln His Tyr Ser Glu Asn Met Phe Ser Phe Glu Val 
385                 390                 395                 400 


Glu Lys Glu Gln Phe Ala Leu Lys Pro Met Asn Cys Pro Gly His Cys 
                405                 410                 415     


Leu Met Phe Asp His Arg Pro Arg Ser Trp Arg Glu Leu Pro Leu Arg 
            420                 425                 430         


Leu Ala Asp Phe Gly Val Leu His Arg Asn Glu Leu Ser Gly Ala Leu 
        435                 440                 445             


Thr Gly Leu Thr Arg Val Arg Arg Phe Gln Gln Asp Asp Ala His Ile 
    450                 455                 460                 


Phe Cys Ala Met Glu Gln Ile Glu Asp Glu Ile Lys Gly Cys Leu Asp 
465                 470                 475                 480 


Phe Leu Arg Thr Val Tyr Ser Val Phe Gly Phe Ser Phe Lys Leu Asn 
                485                 490                 495     


Leu Ser Thr Arg Pro Glu Lys Phe Leu Gly Asp Ile Glu Ile Trp Asn 
            500                 505                 510         


Gln Ala Glu Lys Gln Leu Glu Asn Ser Leu Asn Glu Phe Gly Glu Lys 
        515                 520                 525             


Trp Glu Leu Asn Pro Gly Asp Gly Ala Phe Tyr Gly Pro Lys Ile Asp 
    530                 535                 540                 


Ile Gln Ile Lys Asp Ala Ile Gly Arg Tyr His Gln Cys Ala Thr Ile 
545                 550                 555                 560 


Gln Leu Asp Phe Gln Leu Pro Ile Arg Phe Asn Leu Thr Tyr Val Ser 
                565                 570                 575     


His Asp Gly Asp Asp Lys Lys Arg Pro Val Ile Val His Arg Ala Ile 
            580                 585                 590         


Leu Gly Ser Val Glu Arg Met Ile Ala Ile Leu Thr Glu Asn Tyr Gly 
        595                 600                 605             


Gly Lys Trp Pro Phe Trp Leu Ser Pro Arg Gln Val Met Val Val Pro 
    610                 615                 620                 


Val Gly Pro Thr Cys Asp Glu Tyr Ala Gln Lys Val Arg Gln Gln Phe 
625                 630                 635                 640 


His Asp Ala Lys Phe Met Ala Asp Thr Asp Leu Asp Pro Gly Cys Thr 
                645                 650                 655     


Leu Asn Lys Lys Ile Arg Asn Ala Gln Leu Ala Gln Tyr Asn Phe Ile 
            660                 665                 670         


Leu Val Val Gly Glu Lys Glu Lys Ala Ser Gly Thr Val Asn Ile Arg 
        675                 680                 685             


Thr Arg Asp Asn Lys Val His Gly Glu Arg Thr Val Glu Glu Thr Val 
    690                 695                 700                 


Arg Arg Leu Gln Gln Leu Lys Gln Thr Arg Ser Lys Gln Ala Glu Glu 
705                 710                 715                 720 


Glu Phe 
        


<210>  4
<211>  725
<212>  PRT
<213>  Caenorhabditis elegans

<400>  4

Met Arg Leu Asn Cys Phe Arg Ile Phe Val His Ile Gln Lys Pro Thr 
1               5                   10                  15      


Gln Ile Phe Lys Pro Phe Tyr Arg Ser Leu Ser Ser Glu Ala Ser Asp 
            20                  25                  30          


Lys Tyr His Phe Val Asn Gly His Lys Met Ser Lys Ala Pro Thr Asp 
        35                  40                  45              


Met Ala Pro Trp Pro Ala Phe Ile Glu Glu Arg Ile Lys Leu Trp Asp 
    50                  55                  60                  


Lys Leu Lys Ala Glu Tyr Asp Ala Glu Ile Ala Ala Lys Glu Ser Glu 
65                  70                  75                  80  


Pro Ile Gln Ile Thr Leu Pro Asp Gly Lys Ile His Glu Gly Lys Thr 
                85                  90                  95      


Trp Arg Thr Thr Pro Phe Glu Ile Ala Glu Arg Ile Ser Lys Gly Leu 
            100                 105                 110         


Ala Glu Ala Ala Val Ile Ala Lys Val Asn Gly Ala Val Trp Asp Leu 
        115                 120                 125             


Asp Arg Pro Phe Glu Gly Asn Ala Lys Leu Glu Leu Leu Lys Phe Asp 
    130                 135                 140                 


Asp Asp Glu Ala Lys Gln Val Phe Trp His Ser Ser Ala His Val Leu 
145                 150                 155                 160 


Gly Glu Ala Met Glu Arg Tyr Cys Gly Gly His Leu Cys Tyr Gly Pro 
                165                 170                 175     


Pro Ile Gln Glu Gly Phe Tyr Tyr Asp Met Trp His Glu Asn Arg Thr 
            180                 185                 190         


Ile Cys Pro Asp Asp Phe Pro Lys Ile Asp Gln Ile Val Lys Ala Ala 
        195                 200                 205             


Val Lys Asp Lys Gln Lys Phe Glu Arg Leu Glu Met Thr Lys Glu Asp 
    210                 215                 220                 


Leu Leu Glu Met Phe Lys Tyr Asn Glu Phe Lys Val Arg Ile Ile Thr 
225                 230                 235                 240 


Glu Lys Ile His Thr Pro Lys Thr Thr Val Tyr Arg Cys Gly Pro Leu 
                245                 250                 255     


Ile Asp Leu Cys Arg Gly Pro His Val Arg His Thr Gly Lys Val Lys 
            260                 265                 270         


Ala Met Ala Ile Thr Lys Asn Ser Ser Ser Tyr Trp Glu Gly Lys Ala 
        275                 280                 285             


Asp Ala Glu Ser Leu Gln Arg Leu Tyr Gly Ile Ser Phe Pro Asp Ser 
    290                 295                 300                 


Lys Gln Leu Lys Glu Trp Gln Lys Leu Gln Glu Glu Ala Ala Lys Arg 
305                 310                 315                 320 


Asp His Arg Lys Leu Gly Lys Glu His Asp Leu Phe Phe Phe His Gln 
                325                 330                 335     


Leu Ser Pro Gly Ser Ala Phe Trp Tyr Pro Lys Gly Ala His Ile Tyr 
            340                 345                 350         


Asn Lys Leu Val Asp Phe Ile Arg Lys Gln Tyr Arg Arg Arg Gly Phe 
        355                 360                 365             


Thr Glu Val Ile Thr Pro Asn Met Tyr Asn Lys Lys Leu Trp Glu Thr 
    370                 375                 380                 


Ser Gly His Trp Gln His Tyr Ser Glu Asp Met Phe Lys Ile Glu Val 
385                 390                 395                 400 


Glu Lys Glu Glu Phe Gly Leu Lys Pro Met Asn Cys Pro Gly His Cys 
                405                 410                 415     


Leu Met Phe Gly His Met Pro His Thr Tyr Asn Glu Leu Pro Phe Arg 
            420                 425                 430         


Phe Ala Asp Phe Gly Val Leu His Arg Asn Glu Met Ser Gly Ala Leu 
        435                 440                 445             


Thr Gly Leu Thr Arg Val Arg Arg Phe Gln Gln Asp Asp Ala His Ile 
    450                 455                 460                 


Phe Cys Arg Gln Asp Gln Ile Ser Glu Glu Ile Lys Gln Cys Leu Asp 
465                 470                 475                 480 


Phe Leu Glu Tyr Ala Tyr Glu Lys Val Phe Gly Phe Thr Phe Lys Leu 
                485                 490                 495     


Asn Leu Ser Thr Arg Pro Glu Gly Phe Leu Gly Asn Ile Glu Thr Trp 
            500                 505                 510         


Asp Lys Ala Glu Ala Asp Leu Thr Asn Ala Leu Asn Ala Ser Gly Arg 
        515                 520                 525             


Lys Trp Val Leu Asn Pro Gly Asp Gly Ala Phe Tyr Gly Pro Lys Ile 
    530                 535                 540                 


Asp Ile Thr Ile Gln Asp Ala Leu Lys Arg Asn Phe Gln Cys Ala Thr 
545                 550                 555                 560 


Ile Gln Leu Asp Phe Gln Leu Pro Asn Gln Phe Asp Leu Ser Tyr Phe 
                565                 570                 575     


Asp Glu Lys Gly Glu Lys Gln Arg Pro Val Met Ile His Arg Ala Val 
            580                 585                 590         


Leu Gly Ser Val Glu Arg Met Thr Ala Ile Leu Thr Glu Ser Tyr Gly 
        595                 600                 605             


Gly Lys Trp Pro Phe Trp Leu Ser Pro Arg Gln Cys Lys Ile Ile Thr 
    610                 615                 620                 


Val His Glu Ser Val Arg Asp Tyr Ala Asn Asp Val Lys Lys Gln Ile 
625                 630                 635                 640 


Phe Glu Ala Gly Phe Glu Ile Glu Tyr Glu Glu Asn Cys Gly Asp Thr 
                645                 650                 655     


Met Asn Lys Gln Val Arg Lys Ala Gln Leu Ala Gln Phe Asn Phe Ile 
            660                 665                 670         


Leu Val Ile Gly Ala Lys Glu Lys Glu Asn Gly Thr Val Asn Val Arg 
        675                 680                 685             


Thr Arg Asp Asn Ala Val Arg Gly Glu Val Ala Leu Asp Lys Leu Ile 
    690                 695                 700                 


Ser Lys Phe Arg Arg Phe Ala Asp Glu Tyr Val Ala Asp Thr Glu Lys 
705                 710                 715                 720 


Ser Glu Glu Trp Ala 
                725 


<210>  5
<211>  734
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  5

Met Ser Ala Ser Glu Ala Gly Val Thr Glu Gln Val Lys Lys Leu Ser 
1               5                   10                  15      


Val Lys Asp Ser Ser Asn Asp Ala Val Lys Pro Asn Lys Lys Glu Asn 
            20                  25                  30          


Lys Lys Ser Lys Gln Gln Ser Leu Tyr Leu Asp Pro Glu Pro Thr Phe 
        35                  40                  45              


Ile Glu Glu Arg Ile Glu Met Phe Asp Arg Leu Gln Lys Glu Tyr Asn 
    50                  55                  60                  


Asp Lys Val Ala Ser Met Pro Arg Val Pro Leu Lys Ile Val Leu Lys 
65                  70                  75                  80  


Asp Gly Ala Val Lys Glu Ala Thr Ser Trp Glu Thr Thr Pro Met Asp 
                85                  90                  95      


Ile Ala Lys Gly Ile Ser Lys Ser Leu Ala Asp Arg Leu Cys Ile Ser 
            100                 105                 110         


Lys Val Asn Gly Gln Leu Trp Asp Leu Asp Arg Pro Phe Glu Gly Glu 
        115                 120                 125             


Ala Asn Glu Glu Ile Lys Leu Glu Leu Leu Asp Phe Glu Ser Asp Glu 
    130                 135                 140                 


Gly Lys Lys Val Phe Trp His Ser Ser Ala His Val Leu Gly Glu Ser 
145                 150                 155                 160 


Cys Glu Cys His Leu Gly Ala His Ile Cys Leu Gly Pro Pro Thr Asp 
                165                 170                 175     


Asp Gly Phe Phe Tyr Glu Met Ala Val Arg Asp Ser Met Lys Asp Ile 
            180                 185                 190         


Ser Glu Ser Pro Glu Arg Thr Val Ser Gln Ala Asp Phe Pro Gly Leu 
        195                 200                 205             


Glu Gly Val Ala Lys Asn Val Ile Lys Gln Lys Gln Lys Phe Glu Arg 
    210                 215                 220                 


Leu Val Met Ser Lys Glu Asp Leu Leu Lys Met Phe His Tyr Ser Lys 
225                 230                 235                 240 


Tyr Lys Thr Tyr Leu Val Gln Thr Lys Val Pro Asp Gly Gly Ala Thr 
                245                 250                 255     


Thr Val Tyr Arg Cys Gly Lys Leu Ile Asp Leu Cys Val Gly Pro His 
            260                 265                 270         


Ile Pro His Thr Gly Arg Ile Lys Ala Phe Lys Leu Leu Lys Asn Ser 
        275                 280                 285             


Ser Cys Tyr Phe Leu Gly Asp Ala Thr Asn Asp Ser Leu Gln Arg Val 
    290                 295                 300                 


Tyr Gly Ile Ser Phe Pro Asp Lys Lys Leu Met Asp Ala His Leu Lys 
305                 310                 315                 320 


Phe Leu Ala Glu Ala Ser Met Arg Asp His Arg Lys Ile Gly Lys Glu 
                325                 330                 335     


Gln Glu Leu Phe Leu Phe Asn Glu Met Ser Pro Gly Ser Cys Phe Trp 
            340                 345                 350         


Leu Pro His Gly Thr Arg Ile Tyr Asn Thr Leu Val Asp Leu Leu Arg 
        355                 360                 365             


Thr Glu Tyr Arg Lys Arg Gly Tyr Glu Glu Val Ile Thr Pro Asn Met 
    370                 375                 380                 


Tyr Asn Ser Lys Leu Trp Glu Thr Ser Gly His Trp Ala Asn Tyr Lys 
385                 390                 395                 400 


Glu Asn Met Phe Thr Phe Glu Val Glu Lys Glu Thr Phe Gly Leu Lys 
                405                 410                 415     


Pro Met Asn Cys Pro Gly His Cys Leu Met Phe Lys Ser Arg Glu Arg 
            420                 425                 430         


Ser Tyr Arg Glu Leu Pro Trp Arg Val Ala Asp Phe Gly Val Ile His 
        435                 440                 445             


Arg Asn Glu Phe Ser Gly Ala Leu Ser Gly Leu Thr Arg Val Arg Arg 
    450                 455                 460                 


Phe Gln Gln Asp Asp Ala His Ile Phe Cys Thr His Asp Gln Ile Glu 
465                 470                 475                 480 


Ser Glu Ile Glu Asn Ile Phe Asn Phe Leu Gln Tyr Ile Tyr Gly Val 
                485                 490                 495     


Phe Gly Phe Glu Phe Lys Met Glu Leu Ser Thr Arg Pro Glu Lys Tyr 
            500                 505                 510         


Val Gly Lys Ile Glu Thr Trp Asp Ala Ala Glu Ser Lys Leu Glu Ser 
        515                 520                 525             


Ala Leu Lys Lys Trp Gly Gly Asn Trp Glu Ile Asn Ala Gly Asp Gly 
    530                 535                 540                 


Ala Phe Tyr Gly Pro Lys Ile Asp Ile Met Ile Ser Asp Ala Leu Arg 
545                 550                 555                 560 


Arg Trp His Gln Cys Ala Thr Ile Gln Leu Asp Phe Gln Leu Pro Asn 
                565                 570                 575     


Arg Phe Glu Leu Glu Phe Lys Ser Lys Asp Gln Asp Ser Glu Ser Tyr 
            580                 585                 590         


Glu Arg Pro Val Met Ile His Arg Ala Ile Leu Gly Ser Val Glu Arg 
        595                 600                 605             


Met Thr Ala Ile Leu Thr Glu His Phe Ala Gly Lys Trp Pro Phe Trp 
    610                 615                 620                 


Leu Ser Pro Arg Gln Val Leu Val Val Pro Val Gly Val Lys Tyr Gln 
625                 630                 635                 640 


Gly Tyr Ala Glu Asp Val Arg Asn Lys Leu His Asp Ala Gly Phe Tyr 
                645                 650                 655     


Ala Asp Val Asp Leu Thr Gly Asn Thr Leu Gln Lys Lys Val Arg Asn 
            660                 665                 670         


Gly Gln Met Leu Lys Tyr Asn Phe Ile Phe Ile Val Gly Glu Gln Glu 
        675                 680                 685             


Met Asn Glu Lys Ser Val Asn Ile Arg Asn Arg Asp Val Met Glu Gln 
    690                 695                 700                 


Gln Gly Lys Asn Ala Thr Val Ser Val Glu Glu Val Leu Lys Gln Leu 
705                 710                 715                 720 


Arg Asn Leu Lys Asp Glu Lys Arg Gly Asp Asn Val Leu Ala 
                725                 730                 


<210>  6
<211>  723
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Phe Glu Glu Lys Ala Ser Ser Pro Ser Gly Lys Met Gly Gly Glu 
1               5                   10                  15      


Glu Lys Pro Ile Gly Ala Gly Glu Glu Lys Gln Lys Glu Gly Gly Lys 
            20                  25                  30          


Lys Lys Asn Lys Glu Gly Ser Gly Asp Gly Gly Arg Ala Glu Leu Asn 
        35                  40                  45              


Pro Trp Pro Glu Tyr Ile Tyr Thr Arg Leu Glu Met Tyr Asn Ile Leu 
    50                  55                  60                  


Lys Ala Glu His Asp Ser Ile Leu Ala Glu Lys Ala Glu Lys Asp Ser 
65                  70                  75                  80  


Lys Pro Ile Lys Val Thr Leu Pro Asp Gly Lys Gln Val Asp Ala Glu 
                85                  90                  95      


Ser Trp Lys Thr Thr Pro Tyr Gln Ile Ala Cys Gly Ile Ser Gln Gly 
            100                 105                 110         


Leu Ala Asp Asn Thr Val Ile Ala Lys Val Asn Asn Val Val Trp Asp 
        115                 120                 125             


Leu Asp Arg Pro Leu Glu Glu Asp Cys Thr Leu Glu Leu Leu Lys Phe 
    130                 135                 140                 


Glu Asp Glu Glu Ala Gln Ala Val Tyr Trp His Ser Ser Ala His Ile 
145                 150                 155                 160 


Met Gly Glu Ala Met Glu Arg Val Tyr Gly Gly Cys Leu Cys Tyr Gly 
                165                 170                 175     


Pro Pro Ile Glu Asn Gly Phe Tyr Tyr Asp Met Tyr Leu Glu Glu Gly 
            180                 185                 190         


Gly Val Ser Ser Asn Asp Phe Ser Ser Leu Glu Ala Leu Cys Lys Lys 
        195                 200                 205             


Ile Ile Lys Glu Lys Gln Ala Phe Glu Arg Leu Glu Val Lys Lys Glu 
    210                 215                 220                 


Thr Leu Leu Ala Met Phe Lys Tyr Asn Lys Phe Lys Cys Arg Ile Leu 
225                 230                 235                 240 


Asn Glu Lys Val Asn Thr Pro Thr Thr Thr Val Tyr Arg Cys Gly Pro 
                245                 250                 255     


Leu Ile Asp Leu Cys Arg Gly Pro His Val Arg His Thr Gly Lys Ile 
            260                 265                 270         


Lys Ala Leu Lys Ile His Lys Asn Ser Ser Thr Tyr Trp Glu Gly Lys 
        275                 280                 285             


Ala Asp Met Glu Thr Leu Gln Arg Ile Tyr Gly Ile Ser Phe Pro Asp 
    290                 295                 300                 


Pro Lys Met Leu Lys Glu Trp Glu Lys Phe Gln Glu Glu Ala Lys Asn 
305                 310                 315                 320 


Arg Asp His Arg Lys Ile Gly Arg Asp Gln Glu Leu Tyr Phe Phe His 
                325                 330                 335     


Glu Leu Ser Pro Gly Ser Cys Phe Phe Leu Pro Lys Gly Ala Tyr Ile 
            340                 345                 350         


Tyr Asn Ala Leu Ile Glu Phe Ile Arg Ser Glu Tyr Arg Lys Arg Gly 
        355                 360                 365             


Phe Gln Glu Val Val Thr Pro Asn Ile Phe Asn Ser Arg Leu Trp Met 
    370                 375                 380                 


Thr Ser Gly His Trp Gln His Tyr Ser Glu Asn Met Phe Ser Phe Glu 
385                 390                 395                 400 


Val Glu Lys Glu Leu Phe Ala Leu Lys Pro Met Asn Cys Pro Gly His 
                405                 410                 415     


Cys Leu Met Phe Asp His Arg Pro Arg Ser Trp Arg Glu Leu Pro Leu 
            420                 425                 430         


Arg Leu Ala Asp Phe Gly Val Leu His Arg Asn Glu Leu Ser Gly Ala 
        435                 440                 445             


Leu Thr Gly Leu Thr Arg Val Arg Arg Phe Gln Gln Asp Asp Ala His 
    450                 455                 460                 


Ile Phe Cys Ala Met Glu Gln Ile Glu Asp Glu Ile Lys Gly Cys Leu 
465                 470                 475                 480 


Asp Phe Leu Arg Thr Val Tyr Ser Val Phe Gly Phe Ser Phe Lys Leu 
                485                 490                 495     


Asn Leu Ser Thr Arg Pro Glu Lys Phe Leu Gly Asp Ile Glu Val Trp 
            500                 505                 510         


Asp Gln Ala Glu Lys Gln Leu Glu Asn Ser Leu Asn Glu Phe Gly Glu 
        515                 520                 525             


Lys Trp Glu Leu Asn Ser Gly Asp Gly Ala Phe Tyr Gly Pro Lys Ile 
    530                 535                 540                 


Asp Ile Gln Ile Lys Asp Ala Ile Gly Arg Tyr His Gln Cys Ala Thr 
545                 550                 555                 560 


Ile Gln Leu Asp Phe Gln Leu Pro Ile Arg Phe Asn Leu Thr Tyr Val 
                565                 570                 575     


Ser His Asp Gly Asp Asp Lys Lys Arg Pro Val Ile Val His Arg Ala 
            580                 585                 590         


Ile Leu Gly Ser Val Glu Arg Met Ile Ala Ile Leu Thr Glu Asn Tyr 
        595                 600                 605             


Gly Gly Lys Trp Pro Phe Trp Leu Ser Pro Arg Gln Val Met Val Val 
    610                 615                 620                 


Pro Val Gly Pro Thr Cys Asp Glu Tyr Ala Gln Lys Val Arg Gln Gln 
625                 630                 635                 640 


Phe His Asp Ala Lys Phe Met Ala Asp Ile Asp Leu Asp Pro Gly Cys 
                645                 650                 655     


Thr Leu Asn Lys Lys Ile Arg Asn Ala Gln Leu Ala Gln Tyr Asn Phe 
            660                 665                 670         


Ile Leu Val Val Gly Glu Lys Glu Lys Ile Ser Gly Thr Val Asn Ile 
        675                 680                 685             


Arg Thr Arg Asp Asn Lys Val His Gly Glu Arg Thr Ile Ser Glu Thr 
    690                 695                 700                 


Ile Glu Arg Leu Gln Gln Leu Lys Glu Phe Arg Ser Lys Gln Ala Glu 
705                 710                 715                 720 


Glu Glu Phe 
            


<210>  7
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  7

Arg Ala Glu Leu Asn Pro Trp Pro Glu Tyr Ile Tyr Thr Arg Leu Glu 
1               5                   10                  15      


Met Tyr Asn Ile Leu Lys Ala Glu His Asp Ser Ile Leu Ala Glu Lys 
            20                  25                  30          


Ala Glu Lys Asp Ser Lys Pro Ile Lys Val Thr Leu Pro Asp Gly Lys 
        35                  40                  45              


Gln Val Asp Ala Glu Ser Trp Lys Thr Thr Pro Tyr Gln Ile Ala Cys 
    50                  55                  60                  


Gly Ile Ser Gln Gly Leu Ala Asp Asn Thr Val Ile Ala Lys Val Asn 
65                  70                  75                  80  


Asn Val Val Trp Asp Leu Asp Arg Pro Leu Glu Glu Asp Cys Thr Leu 
                85                  90                  95      


Glu Leu Leu Lys 
            100 


<210>  8
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  8
caccagtgtg caaccatcca gctggatttc caggtgccca tcagatttaa tc               52


<210>  9
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  9
gattaaatct gatgggccac tggaaatcca gctggatggt tgcacactgg tg               52


