                         SEQUENCE LISTING

<110>  Pharmacyclics, Inc
       Chang, Betty Y.
       Buggy, Joseph J.
       Steggerda, Susanne M.
 
<120>  MUTATIONS ASSOCIATED WITH RESISTANCE TO INHIBITORS OF BRUTON'S 
       TYROSINE KINASE (BTK)

<130>  25922-865.601

<150>  US 61/675,303
<151>  2012-07-24

<150>  US 61/682,688
<151>  2012-08-13

<150>  US 61/780,652
<151>  2013-03-13

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  659
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ala Val Ile Leu Glu Ser Ile Phe Leu Lys Arg Ser Gln Gln 
1               5                   10                  15      


Lys Lys Lys Thr Ser Pro Leu Asn Phe Lys Lys Arg Leu Phe Leu Leu 
            20                  25                  30          


Thr Val His Lys Leu Ser Tyr Tyr Glu Tyr Asp Phe Glu Arg Gly Arg 
        35                  40                  45              


Arg Gly Ser Lys Lys Gly Ser Ile Asp Val Glu Lys Ile Thr Cys Val 
    50                  55                  60                  


Glu Thr Val Val Pro Glu Lys Asn Pro Pro Pro Glu Arg Gln Ile Pro 
65                  70                  75                  80  


Arg Arg Gly Glu Glu Ser Ser Glu Met Glu Gln Ile Ser Ile Ile Glu 
                85                  90                  95      


Arg Phe Pro Tyr Pro Phe Gln Val Val Tyr Asp Glu Gly Pro Leu Tyr 
            100                 105                 110         


Val Phe Ser Pro Thr Glu Glu Leu Arg Lys Arg Trp Ile His Gln Leu 
        115                 120                 125             


Lys Asn Val Ile Arg Tyr Asn Ser Asp Leu Val Gln Lys Tyr His Pro 
    130                 135                 140                 


Cys Phe Trp Ile Asp Gly Gln Tyr Leu Cys Cys Ser Gln Thr Ala Lys 
145                 150                 155                 160 


Asn Ala Met Gly Cys Gln Ile Leu Glu Asn Arg Asn Gly Ser Leu Lys 
                165                 170                 175     


Pro Gly Ser Ser His Arg Lys Thr Lys Lys Pro Leu Pro Pro Thr Pro 
            180                 185                 190         


Glu Glu Asp Gln Ile Leu Lys Lys Pro Leu Pro Pro Glu Pro Ala Ala 
        195                 200                 205             


Ala Pro Val Ser Thr Ser Glu Leu Lys Lys Val Val Ala Leu Tyr Asp 
    210                 215                 220                 


Tyr Met Pro Met Asn Ala Asn Asp Leu Gln Leu Arg Lys Gly Asp Glu 
225                 230                 235                 240 


Tyr Phe Ile Leu Glu Glu Ser Asn Leu Pro Trp Trp Arg Ala Arg Asp 
                245                 250                 255     


Lys Asn Gly Gln Glu Gly Tyr Ile Pro Ser Asn Tyr Val Thr Glu Ala 
            260                 265                 270         


Glu Asp Ser Ile Glu Met Tyr Glu Trp Tyr Ser Lys His Met Thr Arg 
        275                 280                 285             


Ser Gln Ala Glu Gln Leu Leu Lys Gln Glu Gly Lys Glu Gly Gly Phe 
    290                 295                 300                 


Ile Val Arg Asp Ser Ser Lys Ala Gly Lys Tyr Thr Val Ser Val Phe 
305                 310                 315                 320 


Ala Lys Ser Thr Gly Asp Pro Gln Gly Val Ile Arg His Tyr Val Val 
                325                 330                 335     


Cys Ser Thr Pro Gln Ser Gln Tyr Tyr Leu Ala Glu Lys His Leu Phe 
            340                 345                 350         


Ser Thr Ile Pro Glu Leu Ile Asn Tyr His Gln His Asn Ser Ala Gly 
        355                 360                 365             


Leu Ile Ser Arg Leu Lys Tyr Pro Val Ser Gln Gln Asn Lys Asn Ala 
    370                 375                 380                 


Pro Ser Thr Ala Gly Leu Gly Tyr Gly Ser Trp Glu Ile Asp Pro Lys 
385                 390                 395                 400 


Asp Leu Thr Phe Leu Lys Glu Leu Gly Thr Gly Gln Phe Gly Val Val 
                405                 410                 415     


Lys Tyr Gly Lys Trp Arg Gly Gln Tyr Asp Val Ala Ile Lys Met Ile 
            420                 425                 430         


Lys Glu Gly Ser Met Ser Glu Asp Glu Phe Ile Glu Glu Ala Lys Val 
        435                 440                 445             


Met Met Asn Leu Ser His Glu Lys Leu Val Gln Leu Tyr Gly Val Cys 
    450                 455                 460                 


Thr Lys Gln Arg Pro Ile Phe Ile Ile Thr Glu Tyr Met Ala Asn Gly 
465                 470                 475                 480 


Cys Leu Leu Asn Tyr Leu Arg Glu Met Arg His Arg Phe Gln Thr Gln 
                485                 490                 495     


Gln Leu Leu Glu Met Cys Lys Asp Val Cys Glu Ala Met Glu Tyr Leu 
            500                 505                 510         


Glu Ser Lys Gln Phe Leu His Arg Asp Leu Ala Ala Arg Asn Cys Leu 
        515                 520                 525             


Val Asn Asp Gln Gly Val Val Lys Val Ser Asp Phe Gly Leu Ser Arg 
    530                 535                 540                 


Tyr Val Leu Asp Asp Glu Tyr Thr Ser Ser Val Gly Ser Lys Phe Pro 
545                 550                 555                 560 


Val Arg Trp Ser Pro Pro Glu Val Leu Met Tyr Ser Lys Phe Ser Ser 
                565                 570                 575     


Lys Ser Asp Ile Trp Ala Phe Gly Val Leu Met Trp Glu Ile Tyr Ser 
            580                 585                 590         


Leu Gly Lys Met Pro Tyr Glu Arg Phe Thr Asn Ser Glu Thr Ala Glu 
        595                 600                 605             


His Ile Ala Gln Gly Leu Arg Leu Tyr Arg Pro His Leu Ala Ser Glu 
    610                 615                 620                 


Lys Val Tyr Thr Ile Met Tyr Ser Cys Trp His Glu Lys Ala Asp Glu 
625                 630                 635                 640 


Arg Pro Thr Phe Lys Ile Leu Leu Ser Asn Ile Leu Asp Val Met Asp 
                645                 650                 655     


Glu Glu Ser 
            


<210>  2
<211>  659
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Val Ile Leu Glu Ser Ile Phe Leu Lys Arg Ser Gln Gln 
1               5                   10                  15      


Lys Lys Lys Thr Ser Pro Leu Asn Phe Lys Lys Arg Leu Phe Leu Leu 
            20                  25                  30          


Thr Val His Lys Leu Ser Tyr Tyr Glu Tyr Asp Phe Glu Arg Gly Arg 
        35                  40                  45              


Arg Gly Ser Lys Lys Gly Ser Ile Asp Val Glu Lys Ile Thr Cys Val 
    50                  55                  60                  


Glu Thr Val Val Pro Glu Lys Asn Pro Pro Pro Glu Arg Gln Ile Pro 
65                  70                  75                  80  


Arg Arg Gly Glu Glu Ser Ser Glu Met Glu Gln Ile Ser Ile Ile Glu 
                85                  90                  95      


Arg Phe Pro Tyr Pro Phe Gln Val Val Tyr Asp Glu Gly Pro Leu Tyr 
            100                 105                 110         


Val Phe Ser Pro Thr Glu Glu Leu Arg Lys Arg Trp Ile His Gln Leu 
        115                 120                 125             


Lys Asn Val Ile Arg Tyr Asn Ser Asp Leu Val Gln Lys Tyr His Pro 
    130                 135                 140                 


Cys Phe Trp Ile Asp Gly Gln Tyr Leu Cys Cys Ser Gln Thr Ala Lys 
145                 150                 155                 160 


Asn Ala Met Gly Cys Gln Ile Leu Glu Asn Arg Asn Gly Ser Leu Lys 
                165                 170                 175     


Pro Gly Ser Ser His Arg Lys Thr Lys Lys Pro Leu Pro Pro Thr Pro 
            180                 185                 190         


Glu Glu Asp Gln Ile Leu Lys Lys Pro Leu Pro Pro Glu Pro Ala Ala 
        195                 200                 205             


Ala Pro Val Ser Thr Ser Glu Leu Lys Lys Val Val Ala Leu Tyr Asp 
    210                 215                 220                 


Tyr Met Pro Met Asn Ala Asn Asp Leu Gln Leu Arg Lys Gly Asp Glu 
225                 230                 235                 240 


Tyr Phe Ile Leu Glu Glu Ser Asn Leu Pro Trp Trp Arg Ala Arg Asp 
                245                 250                 255     


Lys Asn Gly Gln Glu Gly Tyr Ile Pro Ser Asn Tyr Val Thr Glu Ala 
            260                 265                 270         


Glu Asp Ser Ile Glu Met Tyr Glu Trp Tyr Ser Lys His Met Thr Arg 
        275                 280                 285             


Ser Gln Ala Glu Gln Leu Leu Lys Gln Glu Gly Lys Glu Gly Gly Phe 
    290                 295                 300                 


Ile Val Arg Asp Ser Ser Lys Ala Gly Lys Tyr Thr Val Ser Val Phe 
305                 310                 315                 320 


Ala Lys Ser Thr Gly Asp Pro Gln Gly Val Ile Arg His Tyr Val Val 
                325                 330                 335     


Cys Ser Thr Pro Gln Ser Gln Tyr Tyr Leu Ala Glu Lys His Leu Phe 
            340                 345                 350         


Ser Thr Ile Pro Glu Leu Ile Asn Tyr His Gln His Asn Ser Ala Gly 
        355                 360                 365             


Leu Ile Ser Arg Leu Lys Tyr Pro Val Ser Gln Gln Asn Lys Asn Ala 
    370                 375                 380                 


Pro Ser Thr Ala Gly Leu Gly Tyr Gly Ser Trp Glu Ile Asp Pro Lys 
385                 390                 395                 400 


Asp Leu Thr Phe Leu Lys Glu Leu Gly Thr Gly Gln Phe Gly Val Val 
                405                 410                 415     


Lys Tyr Gly Lys Trp Arg Gly Gln Tyr Asp Val Ala Ile Lys Met Ile 
            420                 425                 430         


Lys Glu Gly Ser Met Ser Glu Asp Glu Phe Ile Glu Glu Ala Lys Val 
        435                 440                 445             


Met Met Asn Leu Ser His Glu Lys Leu Val Gln Leu Tyr Gly Val Cys 
    450                 455                 460                 


Thr Lys Gln Arg Pro Ile Phe Ile Ile Thr Glu Tyr Met Ala Asn Gly 
465                 470                 475                 480 


Ser Leu Leu Asn Tyr Leu Arg Glu Met Arg His Arg Phe Gln Thr Gln 
                485                 490                 495     


Gln Leu Leu Glu Met Cys Lys Asp Val Cys Glu Ala Met Glu Tyr Leu 
            500                 505                 510         


Glu Ser Lys Gln Phe Leu His Arg Asp Leu Ala Ala Arg Asn Cys Leu 
        515                 520                 525             


Val Asn Asp Gln Gly Val Val Lys Val Ser Asp Phe Gly Leu Ser Arg 
    530                 535                 540                 


Tyr Val Leu Asp Asp Glu Tyr Thr Ser Ser Val Gly Ser Lys Phe Pro 
545                 550                 555                 560 


Val Arg Trp Ser Pro Pro Glu Val Leu Met Tyr Ser Lys Phe Ser Ser 
                565                 570                 575     


Lys Ser Asp Ile Trp Ala Phe Gly Val Leu Met Trp Glu Ile Tyr Ser 
            580                 585                 590         


Leu Gly Lys Met Pro Tyr Glu Arg Phe Thr Asn Ser Glu Thr Ala Glu 
        595                 600                 605             


His Ile Ala Gln Gly Leu Arg Leu Tyr Arg Pro His Leu Ala Ser Glu 
    610                 615                 620                 


Lys Val Tyr Thr Ile Met Tyr Ser Cys Trp His Glu Lys Ala Asp Glu 
625                 630                 635                 640 


Arg Pro Thr Phe Lys Ile Leu Leu Ser Asn Ile Leu Asp Val Met Asp 
                645                 650                 655     


Glu Glu Ser 
            


<210>  3
<211>  2611
<212>  DNA
<213>  Homo sapiens

<400>  3
aactgagtgg ctgtgaaagg gtggggtttg ctcagactgt ccttcctctc tggactgtaa       60

gaatatgtct ccagggccag tgtctgctgc gatcgagtcc caccttccaa gtcctggcat      120

ctcaatgcat ctgggaagct acctgcatta agtcaggact gagcacacag gtgaactcca      180

gaaagaagaa gctatggccg cagtgattct ggagagcatc tttctgaagc gatcccaaca      240

gaaaaagaaa acatcacctc taaacttcaa gaagcgcctg tttctcttga ccgtgcacaa      300

actctcctac tatgagtatg actttgaacg tgggagaaga ggcagtaaga agggttcaat      360

agatgttgag aagatcactt gtgttgaaac agtggttcct gaaaaaaatc ctcctccaga      420

aagacagatt ccgagaagag gtgaagagtc cagtgaaatg gagcaaattt caatcattga      480

aaggttccct tatcccttcc aggttgtata tgatgaaggg cctctctacg tcttctcccc      540

aactgaagaa ctaaggaagc ggtggattca ccagctcaaa aacgtaatcc ggtacaacag      600

tgatctggtt cagaaatatc acccttgctt ctggatcgat gggcagtatc tctgctgctc      660

tcagacagcc aaaaatgcta tgggctgcca aattttggag aacaggaatg gaagcttaaa      720

acctgggagt tctcaccgga agacaaaaaa gcctcttccc ccaacgcctg aggaggacca      780

gatcttgaaa aagccactac cgcctgagcc agcagcagca ccagtctcca caagtgagct      840

gaaaaaggtt gtggcccttt atgattacat gccaatgaat gcaaatgatc tacagctgcg      900

gaagggtgat gaatatttta tcttggagga aagcaactta ccatggtgga gagcacgaga      960

taaaaatggg caggaaggct acattcctag taactatgtc actgaagcag aagactccat     1020

agaaatgtat gagtggtatt ccaaacacat gactcggagt caggctgagc aactgctaaa     1080

gcaagagggg aaagaaggag gtttcattgt cagagactcc agcaaagctg gcaaatatac     1140

agtgtctgtg tttgctaaat ccacagggga ccctcaaggg gtgatacgtc attatgttgt     1200

gtgttccaca cctcagagcc agtattacct ggctgagaag caccttttca gcaccatccc     1260

tgagctcatt aactaccatc agcacaactc tgcaggactc atatccaggc tcaaatatcc     1320

agtgtctcaa caaaacaaga atgcaccttc cactgcaggc ctgggatacg gatcatggga     1380

aattgatcca aaggacctga ccttcttgaa ggagctgggg actggacaat ttggggtagt     1440

gaagtatggg aaatggagag gccagtacga cgtggccatc aagatgatca aagaaggctc     1500

catgtctgaa gatgaattca ttgaagaagc caaagtcatg atgaatcttt cccatgagaa     1560

gctggtgcag ttgtatggcg tctgcaccaa gcagcgcccc atcttcatca tcactgagta     1620

catggccaat ggctgcctcc tgaactacct gagggagatg cgccaccgct tccagactca     1680

gcagctgcta gagatgtgca aggatgtctg tgaagccatg gaatacctgg agtcaaagca     1740

gttccttcac cgagacctgg cagctcgaaa ctgtttggta aacgatcaag gagttgttaa     1800

agtatctgat ttcggcctgt ccaggtatgt cctggatgat gaatacacaa gctcagtagg     1860

ctccaaattt ccagtccggt ggtccccacc ggaagtcctg atgtatagca agttcagcag     1920

caaatctgac atttgggctt ttggggtttt gatgtgggaa atttactccc tggggaagat     1980

gccatatgag agatttacta acagtgagac tgctgaacac attgcccaag gcctacgtct     2040

ctacaggcct catctggctt cagagaaggt atataccatc atgtacagtt gctggcatga     2100

gaaagcagat gagcgtccca ctttcaaaat tcttctgagc aatattctag atgtcatgga     2160

tgaagaatcc tgagctcgcc aataagcttc ttggttctac ttctcttctc cacaagcccc     2220

aatttcactt tctcagagga aatcccaagc ttaggagccc tggagccttt gtgctcccac     2280

tcaatacaaa aaggcccctc tctacatctg ggaatgcacc tcttctttga ttccctggga     2340

tagtggcttc tgagcaaagg ccaagaaatt attgtgcctg aaatttcccg agagaattaa     2400

gacagactga atttgcgatg aaaatatttt ttaggaggga ggatgtaaat agccgcacaa     2460

aggggtccaa cagctctttg agtaggcatt tggtagagct tgggggtgtg tgtgtggggg     2520

tggaccgaat ttggcaagaa tgaaatggtg tcataaagat gggaggggag ggtgttttga     2580

taaaataaaa ttactagaaa gcttgaaagt c                                    2611


<210>  4
<211>  659
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ala Ala Val Ile Leu Glu Ser Ile Phe Leu Lys Arg Ser Gln Gln 
1               5                   10                  15      


Lys Lys Lys Thr Ser Pro Leu Asn Phe Lys Lys Arg Leu Phe Leu Leu 
            20                  25                  30          


Thr Val His Lys Leu Ser Tyr Tyr Glu Tyr Asp Phe Glu Arg Gly Arg 
        35                  40                  45              


Arg Gly Ser Lys Lys Gly Ser Ile Asp Val Glu Lys Ile Thr Cys Val 
    50                  55                  60                  


Glu Thr Val Ile Pro Glu Lys Asn Pro Pro Pro Glu Arg Gln Ile Pro 
65                  70                  75                  80  


Arg Arg Gly Glu Glu Ser Ser Glu Met Glu Gln Ile Ser Ile Ile Glu 
                85                  90                  95      


Arg Phe Pro Tyr Pro Phe Gln Val Val Tyr Asp Glu Gly Pro Leu Tyr 
            100                 105                 110         


Val Phe Ser Pro Thr Glu Glu Leu Arg Lys Arg Trp Ile His Gln Leu 
        115                 120                 125             


Lys Asn Val Ile Arg Tyr Asn Ser Asp Leu Val Gln Lys Tyr His Pro 
    130                 135                 140                 


Cys Phe Trp Ile Asp Gly Gln Tyr Leu Cys Cys Ser Gln Thr Ala Lys 
145                 150                 155                 160 


Asn Ala Met Gly Cys Gln Ile Leu Glu Asn Arg Asn Gly Ser Leu Lys 
                165                 170                 175     


Pro Gly Ser Ser His Arg Lys Thr Lys Lys Pro Leu Pro Pro Thr Pro 
            180                 185                 190         


Glu Glu Asp Gln Ile Leu Lys Lys Pro Leu Pro Pro Glu Pro Thr Ala 
        195                 200                 205             


Ala Pro Ile Ser Thr Thr Glu Leu Lys Lys Val Val Ala Leu Tyr Asp 
    210                 215                 220                 


Tyr Met Pro Met Asn Ala Asn Asp Leu Gln Leu Arg Lys Gly Glu Glu 
225                 230                 235                 240 


Tyr Phe Ile Leu Glu Glu Ser Asn Leu Pro Trp Trp Arg Ala Arg Asp 
                245                 250                 255     


Lys Asn Gly Gln Glu Gly Tyr Ile Pro Ser Asn Tyr Ile Thr Glu Ala 
            260                 265                 270         


Glu Asp Ser Ile Glu Met Tyr Glu Trp Tyr Ser Lys His Met Thr Arg 
        275                 280                 285             


Ser Gln Ala Glu Gln Leu Leu Lys Gln Glu Gly Lys Glu Gly Gly Phe 
    290                 295                 300                 


Ile Val Arg Asp Ser Ser Lys Ala Gly Lys Tyr Thr Val Ser Val Phe 
305                 310                 315                 320 


Ala Lys Ser Thr Gly Glu Pro Gln Gly Val Ile Arg His Tyr Val Val 
                325                 330                 335     


Cys Ser Thr Pro Gln Ser Gln Tyr Tyr Leu Ala Glu Lys His Leu Phe 
            340                 345                 350         


Ser Thr Ile Pro Glu Leu Ile Asn Tyr His Gln His Asn Ser Ala Gly 
        355                 360                 365             


Leu Ile Ser Arg Leu Lys Tyr Pro Val Ser Lys Gln Asn Lys Asn Ala 
    370                 375                 380                 


Pro Ser Thr Ala Gly Leu Gly Tyr Gly Ser Trp Glu Ile Asp Pro Lys 
385                 390                 395                 400 


Asp Leu Thr Phe Leu Lys Glu Leu Gly Thr Gly Gln Phe Gly Val Val 
                405                 410                 415     


Lys Tyr Gly Lys Trp Arg Gly Gln Tyr Asp Val Ala Ile Lys Met Ile 
            420                 425                 430         


Arg Glu Gly Ser Met Ser Glu Asp Glu Phe Ile Glu Glu Ala Lys Val 
        435                 440                 445             


Met Met Asn Leu Ser His Glu Lys Leu Val Gln Leu Tyr Gly Val Cys 
    450                 455                 460                 


Thr Lys Gln Arg Pro Ile Phe Ile Ile Thr Glu Tyr Met Ala Asn Gly 
465                 470                 475                 480 


Cys Leu Leu Asn Tyr Leu Arg Glu Met Arg His Arg Phe Gln Thr Gln 
                485                 490                 495     


Gln Leu Leu Glu Met Cys Lys Asp Val Cys Glu Ala Met Glu Tyr Leu 
            500                 505                 510         


Glu Ser Lys Gln Phe Leu His Arg Asp Leu Ala Ala Arg Asn Cys Leu 
        515                 520                 525             


Val Asn Asp Gln Gly Val Val Lys Val Ser Asp Phe Gly Leu Ser Arg 
    530                 535                 540                 


Tyr Val Leu Asp Asp Glu Tyr Thr Ser Ser Val Gly Ser Lys Phe Pro 
545                 550                 555                 560 


Val Arg Trp Ser Pro Pro Glu Val Leu Met Tyr Ser Lys Phe Ser Ser 
                565                 570                 575     


Lys Ser Asp Ile Trp Ala Phe Gly Val Leu Met Trp Glu Ile Tyr Ser 
            580                 585                 590         


Leu Gly Lys Met Pro Tyr Glu Arg Phe Thr Asn Ser Glu Thr Ala Glu 
        595                 600                 605             


His Ile Ala Gln Gly Leu Arg Leu Tyr Arg Pro His Leu Ala Ser Glu 
    610                 615                 620                 


Arg Val Tyr Thr Ile Met Tyr Ser Cys Trp His Glu Lys Ala Asp Glu 
625                 630                 635                 640 


Arg Pro Ser Phe Lys Ile Leu Leu Ser Asn Ile Leu Asp Val Met Asp 
                645                 650                 655     


Glu Glu Ser 
            


<210>  5
<211>  657
<212>  PRT
<213>  Gallus gallus

<400>  5

Met Ala Ser Ile Ile Leu Glu Ser Ile Phe Leu Lys Arg Ser Gln Gln 
1               5                   10                  15      


Lys Lys Lys Thr Ser Pro Leu Asn Phe Lys Lys Arg Leu Phe Leu Leu 
            20                  25                  30          


Thr Glu Ser Lys Leu Ser Tyr Tyr Glu Tyr Asp Phe Glu Arg Gly Arg 
        35                  40                  45              


Arg Gly Ser Lys Lys Gly Ser Val Asp Ile Glu Lys Ile Thr Cys Val 
    50                  55                  60                  


Glu Thr Val Val Pro Glu Asn Asn Pro Pro Pro Glu Arg Gln Val Pro 
65                  70                  75                  80  


Lys Lys Gly Glu Asp Tyr Asn Met Glu Gln Ile Ser Ile Ile Glu Arg 
                85                  90                  95      


Phe Pro Tyr Pro Phe Gln Val Val Tyr Asp Glu Gly Pro Leu Tyr Val 
            100                 105                 110         


Phe Ser Pro Thr Glu Glu Leu Arg Lys Arg Trp Ile His Gln Leu Lys 
        115                 120                 125             


Ser Val Ile Arg Tyr Asn Ser Asp Leu Val Gln Lys Tyr His Pro Cys 
    130                 135                 140                 


Phe Trp Ile Asp Gly Gln Tyr Leu Cys Cys Ser Gln Thr Ala Lys Asn 
145                 150                 155                 160 


Ala Met Gly Cys Lys Ile Leu Glu Ser Arg Asn Gly Ser Leu Lys Ala 
                165                 170                 175     


Gly Arg Ser His Arg Lys Thr Lys Lys Pro Leu Pro Pro Thr Pro Glu 
            180                 185                 190         


Glu Asp Thr Met Val Met Lys Pro Leu Pro Pro Glu Pro Ala Pro Ser 
        195                 200                 205             


Ala Ala Gly Glu Met Lys Lys Val Val Ala Leu Tyr Asn Tyr Val Pro 
    210                 215                 220                 


Met Asn Val Gln Asp Leu Gln Leu Gln Lys Gly Glu Asp Tyr Leu Ile 
225                 230                 235                 240 


Leu Glu Glu Ser His Leu Pro Trp Trp Lys Ala Arg Asp Lys Asn Gly 
                245                 250                 255     


Arg Glu Gly Tyr Ile Pro Ser Asn Tyr Val Thr Ala Thr Ser Asn Ser 
            260                 265                 270         


Leu Glu Ile Tyr Glu Trp Tyr Ser Lys Asn Ile Thr Arg Ser Gln Ala 
        275                 280                 285             


Glu Gln Leu Leu Lys Gln Glu Gly Lys Glu Gly Gly Phe Ile Val Arg 
    290                 295                 300                 


Asp Ser Thr Ser Lys Thr Gly Lys Tyr Thr Val Ser Val Tyr Ala Lys 
305                 310                 315                 320 


Ser Ala Val Asp Pro Gln Gly Met Ile Arg His Tyr Val Val Cys Cys 
                325                 330                 335     


Thr Pro Gln Asn Gln Tyr Tyr Leu Ala Glu Lys His Leu Phe Asn Thr 
            340                 345                 350         


Ile Pro Glu Leu Ile Thr Tyr His Gln His Asn Ser Ala Gly Leu Ile 
        355                 360                 365             


Ser Arg Leu Lys Tyr Pro Val Ser Arg His Gln Lys Ser Ala Pro Ser 
    370                 375                 380                 


Thr Ala Gly Leu Gly Tyr Gly Ser Trp Glu Ile Asp Pro Lys Asp Leu 
385                 390                 395                 400 


Thr Phe Leu Lys Glu Leu Gly Thr Gly Gln Phe Gly Val Val Lys Tyr 
                405                 410                 415     


Gly Lys Trp Arg Gly Gln Tyr Asn Val Ala Ile Lys Met Ile Arg Glu 
            420                 425                 430         


Gly Ser Met Ser Glu Asp Glu Phe Ile Asp Glu Ala Lys Val Met Met 
        435                 440                 445             


Asn Leu Ser His Glu Lys Leu Val Gln Leu Tyr Gly Val Cys Thr Lys 
    450                 455                 460                 


Gln Arg Pro Ile Phe Ile Ile Thr Glu Tyr Met Ala Asn Gly Cys Leu 
465                 470                 475                 480 


Leu Asn Phe Leu Arg Glu Thr Gln Arg Arg Phe Gln Pro Ala Glu Leu 
                485                 490                 495     


Leu Glu Met Cys Lys Asp Val Cys Glu Ala Met Glu Tyr Leu Glu Ser 
            500                 505                 510         


Lys Gln Phe Leu His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Asn 
        515                 520                 525             


Asp Gln Gly Ile Val Lys Val Ser Asp Phe Gly Leu Ser Arg Tyr Val 
    530                 535                 540                 


Leu Asp Asp Glu Tyr Thr Ser Ser Met Gly Ser Lys Phe Pro Val Arg 
545                 550                 555                 560 


Trp Ser Pro Pro Glu Val Leu Leu Tyr Ser Lys Phe Ser Ser Lys Ser 
                565                 570                 575     


Asp Val Trp Ser Phe Gly Val Leu Met Trp Glu Val Tyr Ser Leu Gly 
            580                 585                 590         


Lys Met Pro Tyr Glu Arg Phe Asn Asn Ser Glu Thr Thr Glu His Val 
        595                 600                 605             


Ile Gln Gly Leu Arg Leu Tyr Arg Pro Gln Gln Ala Ser Glu Arg Val 
    610                 615                 620                 


Tyr Ala Ile Met Tyr Ser Cys Trp His Glu Lys Ala Glu Glu Arg Pro 
625                 630                 635                 640 


Thr Phe Ser Ala Leu Leu Gly Ser Ile Val Asp Ile Thr Asp Glu Glu 
                645                 650                 655     


Pro 
    


<210>  6
<211>  660
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Met Ala Ala Val Ile Leu Glu Ser Ile Phe Leu Lys Arg Ser Gln Gln 
1               5                   10                  15      


Lys Lys Lys Thr Ser Pro Leu Asn Phe Lys Lys Arg Leu Phe Leu Leu 
            20                  25                  30          


Thr Val His Lys Leu Ser Tyr Tyr Glu Tyr Asp Phe Glu Arg Gly Gly 
        35                  40                  45              


Arg Gly Cys Thr Phe His Phe Leu Asp Val Glu Asn Tyr Tyr Cys Val 
    50                  55                  60                  


Glu Asn Ile Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Ser Ser 
65                  70                  75                  80  


Lys Arg Arg Gly Glu Glu Ser Ser Glu Met Glu Gln Ile Ser Ile Ile 
                85                  90                  95      


Glu Arg Phe Pro Tyr Pro Phe Gln Val Val Tyr Asp Glu Gly Pro Leu 
            100                 105                 110         


Tyr Val Phe Ser Pro Thr Glu Glu Leu Arg Lys Arg Trp Ile His Gln 
        115                 120                 125             


Leu Lys Asn Val Ile Arg Tyr Asn Ser Asp Leu Val Gln Lys Tyr His 
    130                 135                 140                 


Pro Cys Phe Trp Ile Asp Gly Gln Tyr Leu Cys Cys Ser Gln Thr Ala 
145                 150                 155                 160 


Lys Asn Ala Met Gly Cys Gln Ile Leu Glu Asn Arg Asn Gly Ser Leu 
                165                 170                 175     


Lys Pro Gly Ser Ser His Arg Lys Thr Lys Lys Pro Leu Pro Pro Thr 
            180                 185                 190         


Pro Glu Glu Asp Gln Ile Leu Lys Lys Pro Leu Pro Pro Glu Pro Thr 
        195                 200                 205             


Ala Ala Pro Ile Ser Thr Ser Glu Leu Lys Lys Val Val Ala Leu Tyr 
    210                 215                 220                 


Asp Tyr Met Pro Met Asn Ala Asn Asp Leu Gln Leu Arg Lys Gly Glu 
225                 230                 235                 240 


Glu Tyr Phe Ile Leu Glu Glu Ser Asn Leu Pro Trp Trp Arg Ala Arg 
                245                 250                 255     


Asp Lys Asn Gly Gln Glu Gly Tyr Ile Pro Ser Asn Tyr Val Thr Glu 
            260                 265                 270         


Ala Glu Asp Ser Ile Glu Met Tyr Glu Trp Tyr Ser Lys His Met Thr 
        275                 280                 285             


Arg Ser Gln Ala Glu Gln Leu Leu Lys Gln Glu Gly Lys Glu Gly Gly 
    290                 295                 300                 


Phe Ile Val Arg Asp Ser Ser Lys Ala Gly Lys Tyr Thr Val Ser Val 
305                 310                 315                 320 


Phe Ala Lys Ser Thr Gly Glu Pro Gln Gly Val Ile Arg His Tyr Val 
                325                 330                 335     


Val Cys Ser Thr Pro Gln Ser Gln Tyr Tyr Leu Ala Glu Lys His Leu 
            340                 345                 350         


Phe Ser Thr Ile Pro Glu Leu Ile Asn Tyr His Gln His Asn Ser Ala 
        355                 360                 365             


Gly Leu Ile Ser Arg Leu Lys Tyr Pro Val Ser Lys Gln Asn Lys Asn 
    370                 375                 380                 


Ala Pro Ser Thr Ala Gly Leu Gly Tyr Gly Ser Trp Glu Ile Asp Pro 
385                 390                 395                 400 


Lys Asp Leu Thr Phe Leu Lys Glu Leu Gly Thr Gly Gln Phe Gly Val 
                405                 410                 415     


Val Lys Tyr Gly Lys Trp Arg Gly Gln Tyr Asp Val Ala Ile Lys Met 
            420                 425                 430         


Ile Arg Glu Gly Ser Met Ser Glu Asp Glu Phe Ile Glu Glu Ala Lys 
        435                 440                 445             


Val Met Met Asn Leu Ser His Glu Lys Leu Val Gln Leu Tyr Gly Val 
    450                 455                 460                 


Cys Thr Lys Gln Arg Pro Ile Phe Ile Ile Thr Glu Tyr Met Ala Asn 
465                 470                 475                 480 


Gly Cys Leu Leu Asn Tyr Leu Arg Glu Met Arg His Arg Phe Gln Thr 
                485                 490                 495     


Gln Gln Leu Leu Glu Met Cys Lys Asp Val Cys Glu Ala Met Glu Tyr 
            500                 505                 510         


Leu Glu Ser Lys Gln Phe Leu His Arg Asp Leu Leu Asp Arg Asp Ser 
        515                 520                 525             


Lys Lys Glu Asn Arg Gly Phe Val Lys Ser Arg Asp Phe Asp Ser Gly 
    530                 535                 540                 


Arg Tyr Val Leu Asp Asp Glu Tyr Thr Ser Ser Val Gly Ser Lys Phe 
545                 550                 555                 560 


Pro Val Arg Trp Ser Pro Pro Glu Val Leu Met Tyr Ser Lys Phe Ser 
                565                 570                 575     


Ser Lys Ser Asp Ile Trp Ala Phe Gly Val Leu Met Trp Glu Ile Tyr 
            580                 585                 590         


Ser Leu Gly Lys Ile Pro Tyr Glu Arg Phe Thr Asn Ser Glu Thr Ala 
        595                 600                 605             


Glu His Ile Ala Gln Gly Leu Arg Leu Tyr Arg Pro His Leu Ala Ser 
    610                 615                 620                 


Asp Arg Val Tyr Thr Ile Met Tyr Ser Cys Trp His Glu Lys Ala Asp 
625                 630                 635                 640 


Glu Arg Pro Ser Phe Lys Ile Leu Leu Ser Asn Ile Leu Asp Val Met 
                645                 650                 655     


Asp Glu Glu Ser 
            660 


<210>  7
<211>  1980
<212>  DNA
<213>  Homo sapiens

<400>  7
atggccgcag tgattctgga gagcatcttt ctgaagcgat cccaacagaa aaagaaaaca       60

tcacctctaa acttcaagaa gcgcctgttt ctcttgaccg tgcacaaact ctcctactat      120

gagtatgact ttgaacgtgg gagaagaggc agtaagaagg gttcaataga tgttgagaag      180

atcacttgtg ttgaaacagt ggttcctgaa aaaaatcctc ctccagaaag acagattccg      240

agaagaggtg aagagtccag tgaaatggag caaatttcaa tcattgaaag gttcccttat      300

cccttccagg ttgtatatga tgaagggcct ctctacgtct tctccccaac tgaagaacta      360

aggaagcggt ggattcacca gctcaaaaac gtaatccggt acaacagtga tctggttcag      420

aaatatcacc cttgcttctg gatcgatggg cagtatctct gctgctctca gacagccaaa      480

aatgctatgg gctgccaaat tttggagaac aggaatggaa gcttaaaacc tgggagttct      540

caccggaaga caaaaaagcc tcttccccca acgcctgagg aggaccagat cttgaaaaag      600

ccactaccgc ctgagccagc agcagcacca gtctccacaa gtgagctgaa aaaggttgtg      660

gccctttatg attacatgcc aatgaatgca aatgatctac agctgcggaa gggtgatgaa      720

tattttatct tggaggaaag caacttacca tggtggagag cacgagataa aaatgggcag      780

gaaggctaca ttcctagtaa ctatgtcact gaagcagaag actccataga aatgtatgag      840

tggtattcca aacacatgac tcggagtcag gctgagcaac tgctaaagca agaggggaaa      900

gaaggaggtt tcattgtcag agactccagc aaagctggca aatatacagt gtctgtgttt      960

gctaaatcca caggggaccc tcaaggggtg atacgtcatt atgttgtgtg ttccacacct     1020

cagagccagt attacctggc tgagaagcac cttttcagca ccatccctga gctcattaac     1080

taccatcagc acaactctgc aggactcata tccaggctca aatatccagt gtctcaacaa     1140

aacaagaatg caccttccac tgcaggcctg ggatacggat catgggaaat tgatccaaag     1200

gacctgacct tcttgaagga gctggggact ggacaatttg gggtagtgaa gtatgggaaa     1260

tggagaggcc agtacgacgt ggccatcaag atgatcaaag aaggctccat gtctgaagat     1320

gaattcattg aagaagccaa agtcatgatg aatctttccc atgagaagct ggtgcagttg     1380

tatggcgtct gcaccaagca gcgccccatc ttcatcatca ctgagtacat ggccaatggc     1440

agcctcctga actacctgag ggagatgcgc caccgcttcc agactcagca gctgctagag     1500

atgtgcaagg atgtctgtga agccatggaa tacctggagt caaagcagtt ccttcaccga     1560

gacctggcag ctcgaaactg tttggtaaac gatcaaggag ttgttaaagt atctgatttc     1620

ggcctgtcca ggtatgtcct ggatgatgaa tacacaagct cagtaggctc caaatttcca     1680

gtccggtggt ccccaccgga agtcctgatg tatagcaagt tcagcagcaa atctgacatt     1740

tgggcttttg gggttttgat gtgggaaatt tactccctgg ggaagatgcc atatgagaga     1800

tttactaaca gtgagactgc tgaacacatt gcccaaggcc tacgtctcta caggcctcat     1860

ctggcttcag agaaggtata taccatcatg tacagttgtt ggcatgagaa agcagatgag     1920

cgtcccactt tcaaaattct tctgagcaat attctagatg tcatggatga agaatcctga     1980


<210>  8
<211>  1980
<212>  DNA
<213>  Homo sapiens

<400>  8
atggccgcag tgattctgga gagcatcttt ctgaagcgat cccaacagaa aaagaaaaca       60

tcacctctaa acttcaagaa gcgcctgttt ctcttgaccg tgcacaaact ctcctactat      120

gagtatgact ttgaacgtgg gagaagaggc agtaagaagg gttcaataga tgttgagaag      180

atcacttgtg ttgaaacagt ggttcctgaa aaaaatcctc ctccagaaag acagattccg      240

agaagaggtg aagagtccag tgaaatggag caaatttcaa tcattgaaag gttcccttat      300

cccttccagg ttgtatatga tgaagggcct ctctacgtct tctccccaac tgaagaacta      360

aggaagcggt ggattcacca gctcaaaaac gtaatccggt acaacagtga tctggttcag      420

aaatatcacc cttgcttctg gatcgatggg cagtatctct gctgctctca gacagccaaa      480

aatgctatgg gctgccaaat tttggagaac aggaatggaa gcttaaaacc tgggagttct      540

caccggaaga caaaaaagcc tcttccccca acgcctgagg aggaccagat cttgaaaaag      600

ccactaccgc ctgagccagc agcagcacca gtctccacaa gtgagctgaa aaaggttgtg      660

gccctttatg attacatgcc aatgaatgca aatgatctac agctgcggaa gggtgatgaa      720

tattttatct tggaggaaag caacttacca tggtggagag cacgagataa aaatgggcag      780

gaaggctaca ttcctagtaa ctatgtcact gaagcagaag actccataga aatgtatgag      840

tggtattcca aacacatgac tcggagtcag gctgagcaac tgctaaagca agaggggaaa      900

gaaggaggtt tcattgtcag agactccagc aaagctggca aatatacagt gtctgtgttt      960

gctaaatcca caggggaccc tcaaggggtg atacgtcatt atgttgtgtg ttccacacct     1020

cagagccagt attacctggc tgagaagcac cttttcagca ccatccctga gctcattaac     1080

taccatcagc acaactctgc aggactcata tccaggctca aatatccagt gtctcaacaa     1140

aacaagaatg caccttccac tgcaggcctg ggatacggat catgggaaat tgatccaaag     1200

gacctgacct tcttgaagga gctggggact ggacaatttg gggtagtgaa gtatgggaaa     1260

tggagaggcc agtacgacgt ggccatcaag atgatcaaag aaggctccat gtctgaagat     1320

gaattcattg aagaagccaa agtcatgatg aatctttccc atgagaagct ggtgcagttg     1380

tatggcgtct gcaccaagca gcgccccatc ttcatcatca ctgagtacat ggccaatggc     1440

tccctcctga actacctgag ggagatgcgc caccgcttcc agactcagca gctgctagag     1500

atgtgcaagg atgtctgtga agccatggaa tacctggagt caaagcagtt ccttcaccga     1560

gacctggcag ctcgaaactg tttggtaaac gatcaaggag ttgttaaagt atctgatttc     1620

ggcctgtcca ggtatgtcct ggatgatgaa tacacaagct cagtaggctc caaatttcca     1680

gtccggtggt ccccaccgga agtcctgatg tatagcaagt tcagcagcaa atctgacatt     1740

tgggcttttg gggttttgat gtgggaaatt tactccctgg ggaagatgcc atatgagaga     1800

tttactaaca gtgagactgc tgaacacatt gcccaaggcc tacgtctcta caggcctcat     1860

ctggcttcag agaaggtata taccatcatg tacagttgct ggcatgagaa agcagatgag     1920

cgtcccactt tcaaaattct tctgagcaat attctagatg tcatggatga agaatcctga     1980


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  9
aagtgaaatt ggggcttgtg                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  10
agtcccacct tccaagtcct                                                   20


<210>  11
<211>  1265
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Thr Thr Val Asn Val Asp Ser Leu Ala Glu Tyr Glu Lys Ser 
1               5                   10                  15      


Gln Ile Lys Arg Ala Leu Glu Leu Gly Thr Val Met Thr Val Phe Ser 
            20                  25                  30          


Phe Arg Lys Ser Thr Pro Glu Arg Arg Thr Val Gln Val Ile Met Glu 
        35                  40                  45              


Thr Arg Gln Val Ala Trp Ser Lys Thr Ala Asp Lys Ile Glu Gly Phe 
    50                  55                  60                  


Leu Asp Ile Met Glu Ile Lys Glu Ile Arg Pro Gly Lys Asn Ser Lys 
65                  70                  75                  80  


Asp Phe Glu Arg Ala Lys Ala Val Arg Gln Lys Glu Asp Cys Cys Phe 
                85                  90                  95      


Thr Ile Leu Tyr Gly Thr Gln Phe Val Leu Ser Thr Leu Ser Leu Ala 
            100                 105                 110         


Ala Asp Ser Lys Glu Asp Ala Val Asn Trp Leu Ser Gly Leu Lys Ile 
        115                 120                 125             


Leu His Gln Glu Ala Met Asn Ala Ser Thr Pro Thr Ile Ile Glu Ser 
    130                 135                 140                 


Trp Leu Arg Lys Gln Ile Tyr Ser Val Asp Gln Thr Arg Arg Asn Ser 
145                 150                 155                 160 


Ile Ser Leu Arg Glu Leu Lys Thr Ile Leu Pro Leu Ile Asn Phe Lys 
                165                 170                 175     


Val Ser Ser Ala Lys Phe Leu Lys Asp Lys Phe Val Glu Ile Gly Ala 
            180                 185                 190         


His Lys Asp Glu Leu Ser Phe Glu Gln Phe His Leu Phe Tyr Lys Lys 
        195                 200                 205             


Leu Met Phe Glu Gln Gln Lys Ser Ile Leu Asp Glu Phe Lys Lys Asp 
    210                 215                 220                 


Ser Ser Val Phe Ile Leu Gly Asn Thr Asp Arg Pro Asp Ala Ser Ala 
225                 230                 235                 240 


Val Tyr Leu His Asp Phe Gln Arg Phe Leu Ile His Glu Gln Gln Glu 
                245                 250                 255     


His Trp Ala Gln Asp Leu Asn Lys Val Arg Glu Arg Met Thr Lys Phe 
            260                 265                 270         


Ile Asp Asp Thr Met Arg Glu Thr Ala Glu Pro Phe Leu Phe Val Asp 
        275                 280                 285             


Glu Phe Leu Thr Tyr Leu Phe Ser Arg Glu Asn Ser Ile Trp Asp Glu 
    290                 295                 300                 


Lys Tyr Asp Ala Val Asp Met Gln Asp Met Asn Asn Pro Leu Ser His 
305                 310                 315                 320 


Tyr Trp Ile Ser Ser Ser His Asn Thr Tyr Leu Thr Gly Asp Gln Leu 
                325                 330                 335     


Arg Ser Glu Ser Ser Pro Glu Ala Tyr Ile Arg Cys Leu Arg Met Gly 
            340                 345                 350         


Cys Arg Cys Ile Glu Leu Asp Cys Trp Asp Gly Pro Asp Gly Lys Pro 
        355                 360                 365             


Val Ile Tyr His Gly Trp Thr Arg Thr Thr Lys Ile Lys Phe Asp Asp 
    370                 375                 380                 


Val Val Gln Ala Ile Lys Asp His Ala Phe Val Thr Ser Ser Phe Pro 
385                 390                 395                 400 


Val Ile Leu Ser Ile Glu Glu His Cys Ser Val Glu Gln Gln Arg His 
                405                 410                 415     


Met Ala Lys Ala Phe Lys Glu Val Phe Gly Asp Leu Leu Leu Thr Lys 
            420                 425                 430         


Pro Thr Glu Ala Ser Ala Asp Gln Leu Pro Ser Pro Ser Gln Leu Arg 
        435                 440                 445             


Glu Lys Ile Ile Ile Lys His Lys Lys Leu Gly Pro Arg Gly Asp Val 
    450                 455                 460                 


Asp Val Asn Met Glu Asp Lys Lys Asp Glu His Lys Gln Gln Gly Glu 
465                 470                 475                 480 


Leu Tyr Met Trp Asp Ser Ile Asp Gln Lys Trp Thr Arg His Tyr Cys 
                485                 490                 495     


Ala Ile Ala Asp Ala Lys Leu Ser Phe Ser Asp Asp Ile Glu Gln Thr 
            500                 505                 510         


Met Glu Glu Glu Val Pro Gln Asp Ile Pro Pro Thr Glu Leu His Phe 
        515                 520                 525             


Gly Glu Lys Trp Phe His Lys Lys Val Glu Lys Arg Thr Ser Ala Glu 
    530                 535                 540                 


Lys Leu Leu Gln Glu Tyr Cys Met Glu Thr Gly Gly Lys Asp Gly Thr 
545                 550                 555                 560 


Phe Leu Val Arg Glu Ser Glu Thr Phe Pro Asn Asp Tyr Thr Leu Ser 
                565                 570                 575     


Phe Trp Arg Ser Gly Arg Val Gln His Cys Arg Ile Arg Ser Thr Met 
            580                 585                 590         


Glu Gly Gly Thr Leu Lys Tyr Tyr Leu Thr Asp Asn Leu Thr Phe Ser 
        595                 600                 605             


Ser Ile Tyr Ala Leu Ile Gln His Tyr Arg Glu Thr His Leu Arg Cys 
    610                 615                 620                 


Ala Glu Phe Glu Leu Arg Leu Thr Asp Pro Val Pro Asn Pro Asn Pro 
625                 630                 635                 640 


His Glu Ser Lys Pro Trp Tyr Tyr Asp Ser Leu Ser Arg Gly Glu Ala 
                645                 650                 655     


Glu Asp Met Leu Met Arg Ile Pro Arg Asp Gly Ala Phe Leu Ile Arg 
            660                 665                 670         


Lys Arg Glu Gly Ser Asp Ser Tyr Ala Ile Thr Phe Arg Ala Arg Gly 
        675                 680                 685             


Lys Val Lys His Cys Arg Ile Asn Arg Asp Gly Arg His Phe Val Leu 
    690                 695                 700                 


Gly Thr Ser Ala Tyr Phe Glu Ser Leu Val Glu Leu Val Ser Tyr Tyr 
705                 710                 715                 720 


Glu Lys His Ser Leu Tyr Arg Lys Met Arg Leu Arg Tyr Pro Val Thr 
                725                 730                 735     


Pro Glu Leu Leu Glu Arg Tyr Asn Met Glu Arg Asp Ile Asn Ser Leu 
            740                 745                 750         


Tyr Asp Val Ser Arg Met Tyr Val Asp Pro Ser Glu Ile Asn Pro Ser 
        755                 760                 765             


Met Pro Gln Arg Thr Val Lys Ala Leu Tyr Asp Tyr Lys Ala Lys Arg 
    770                 775                 780                 


Ser Asp Glu Leu Ser Phe Cys Arg Gly Ala Leu Ile His Asn Val Ser 
785                 790                 795                 800 


Lys Glu Pro Gly Gly Trp Trp Lys Gly Asp Tyr Gly Thr Arg Ile Gln 
                805                 810                 815     


Gln Tyr Phe Pro Ser Asn Tyr Val Glu Asp Ile Ser Thr Ala Asp Phe 
            820                 825                 830         


Glu Glu Leu Glu Lys Gln Ile Ile Glu Asp Asn Pro Leu Gly Ser Leu 
        835                 840                 845             


Cys Arg Gly Ile Leu Asp Leu Asn Thr Tyr Asn Val Val Lys Ala Pro 
    850                 855                 860                 


Gln Gly Lys Asn Gln Lys Ser Phe Val Phe Ile Leu Glu Pro Lys Gln 
865                 870                 875                 880 


Gln Gly Asp Pro Pro Val Glu Phe Ala Thr Asp Arg Val Glu Glu Leu 
                885                 890                 895     


Phe Glu Trp Phe Gln Ser Ile Arg Glu Ile Thr Trp Lys Ile Asp Thr 
            900                 905                 910         


Lys Glu Asn Asn Met Lys Tyr Trp Glu Lys Asn Gln Ser Ile Ala Ile 
        915                 920                 925             


Glu Leu Ser Asp Leu Val Val Tyr Cys Lys Pro Thr Ser Lys Thr Lys 
    930                 935                 940                 


Asp Asn Leu Glu Asn Pro Asp Phe Arg Glu Ile Arg Ser Phe Val Glu 
945                 950                 955                 960 


Thr Lys Ala Asp Ser Ile Ile Arg Gln Lys Pro Val Asp Leu Leu Lys 
                965                 970                 975     


Tyr Asn Gln Lys Gly Leu Thr Arg Val Tyr Pro Lys Gly Gln Arg Val 
            980                 985                 990         


Asp Ser Ser Asn Tyr Asp Pro Phe  Arg Leu Trp Leu Cys  Gly Ser Gln 
        995                 1000                 1005             


Met Val  Ala Leu Asn Phe Gln  Thr Ala Asp Lys Tyr  Met Gln Met 
    1010                 1015                 1020             


Asn His  Ala Leu Phe Ser Leu  Asn Gly Arg Thr Gly  Tyr Val Leu 
    1025                 1030                 1035             


Gln Pro  Glu Ser Met Arg Thr  Glu Lys Tyr Asp Pro  Met Pro Pro 
    1040                 1045                 1050             


Glu Ser  Gln Arg Lys Ile Leu  Met Thr Leu Thr Val  Lys Val Leu 
    1055                 1060                 1065             


Gly Ala  Arg His Leu Pro Lys  Leu Gly Arg Ser Ile  Ala Cys Pro 
    1070                 1075                 1080             


Phe Val  Glu Val Glu Ile Cys  Gly Ala Glu Tyr Asp  Asn Asn Lys 
    1085                 1090                 1095             


Phe Lys  Thr Thr Val Val Asn  Asp Asn Gly Leu Ser  Pro Ile Trp 
    1100                 1105                 1110             


Ala Pro  Thr Gln Glu Lys Val  Thr Phe Glu Ile Tyr  Asp Pro Asn 
    1115                 1120                 1125             


Leu Ala  Phe Leu Arg Phe Val  Val Tyr Glu Glu Asp  Met Phe Ser 
    1130                 1135                 1140             


Asp Pro  Asn Phe Leu Ala His  Ala Thr Tyr Pro Ile  Lys Ala Val 
    1145                 1150                 1155             


Lys Ser  Gly Phe Arg Ser Val  Pro Leu Lys Asn Gly  Tyr Ser Glu 
    1160                 1165                 1170             


Asp Ile  Glu Leu Ala Ser Leu  Leu Val Phe Cys Glu  Met Arg Pro 
    1175                 1180                 1185             


Val Leu  Glu Ser Glu Glu Glu  Leu Tyr Ser Ser Cys  Arg Gln Leu 
    1190                 1195                 1200             


Arg Arg  Arg Gln Glu Glu Leu  Asn Asn Gln Leu Phe  Leu Tyr Asp 
    1205                 1210                 1215             


Thr His  Gln Asn Leu Arg Asn  Ala Asn Arg Asp Ala  Leu Val Lys 
    1220                 1225                 1230             


Glu Phe  Ser Val Asn Glu Asn  Gln Leu Gln Leu Tyr  Gln Glu Lys 
    1235                 1240                 1245             


Cys Asn  Lys Arg Leu Arg Glu  Lys Arg Val Ser Asn  Ser Lys Phe 
    1250                 1255                 1260             


Tyr Ser  
    1265 


<210>  12
<211>  4289
<212>  DNA
<213>  Homo sapiens

<400>  12
agtagcgagc gccggcggcg gagggcgtga gcggcgctga gtgacccgag tcgggacgcg       60

ggctgcgcgc gcgggacccc ggagcccaaa cccggggcag gcgggcagct gtgcccgggc      120

ggcacggcca gcttcctgat ttctcccgat tccttccttc tccctggagc ggccgacaat      180

gtccaccacg gtcaatgtag attcccttgc ggaatatgag aagagccaga tcaagagagc      240

cctggagctg gggacggtga tgactgtgtt cagcttccgc aagtccaccc ccgagcggag      300

aaccgtccag gtgatcatgg agacgcggca ggtggcctgg agcaagaccg ccgacaagat      360

cgagggcttc ttggatatca tggaaataaa agaaatccgc ccagggaaga actccaaaga      420

tttcgagcga gcaaaagcag ttcgccagaa agaagactgc tgcttcacca tcctatatgg      480

cactcagttc gtcctcagca cgctcagctt ggcagctgac tctaaagagg atgcagttaa      540

ctggctctct ggcttgaaaa tcttacacca ggaagcgatg aatgcgtcca cgcccaccat      600

tatcgagagt tggctgagaa agcagatata ttctgtggat caaaccagaa gaaacagcat      660

cagtctccga gagttgaaga ccatcttgcc cctgatcaac tttaaagtga gcagtgccaa      720

gttccttaaa gataagtttg tggaaatagg agcacacaaa gatgagctca gctttgaaca      780

gttccatctc ttctataaaa aacttatgtt tgaacagcaa aaatcgattc tcgatgaatt      840

caaaaaggat tcgtccgtgt tcatcctggg gaacactgac aggccggatg cctctgctgt      900

ttacctgcat gacttccaga ggtttctcat acatgaacag caggagcatt gggctcagga      960

tctgaacaaa gtccgtgagc ggatgacaaa gttcattgat gacaccatgc gtgaaactgc     1020

tgagcctttc ttgtttgtgg atgagttcct cacgtacctg ttttcacgag aaaacagcat     1080

ctgggatgag aagtatgacg cggtggacat gcaggacatg aacaaccccc tgtctcatta     1140

ctggatctcc tcgtcacata acacgtacct tacaggtgac cagctgcgga gcgagtcgtc     1200

cccagaagct tacatccgct gcctgcgcat gggctgtcgc tgcattgaac tggactgctg     1260

ggacgggccc gatgggaagc cggtcatcta ccatggctgg acgcggacta ccaagatcaa     1320

gtttgacgac gtcgtgcagg ccatcaaaga ccacgccttt gttacctcga gcttcccagt     1380

gatcctgtcc atcgaggagc actgcagcgt ggagcaacag cgtcacatgg ccaaggcctt     1440

caaggaagta tttggcgacc tgctgttgac gaagcccacg gaggccagtg ctgaccagct     1500

gccctcgccc agccagctgc gggagaagat catcatcaag cataagaagc tgggcccccg     1560

aggcgatgtg gatgtcaaca tggaggacaa gaaggacgaa cacaagcaac agggggagct     1620

gtacatgtgg gattccattg accagaaatg gactcggcac tactgcgcca ttgccgatgc     1680

caagctgtcc ttcagtgatg acattgaaca gactatggag gaggaagtgc cccaggatat     1740

accccctaca gaactacatt ttggggagaa atggttccac aagaaggtgg agaagaggac     1800

gagtgccgag aagttgctgc aggaatactg catggagacg gggggcaagg atggcacctt     1860

cctggttcgg gagagcgaga ccttccccaa tgactacacc ctgtccttct ggcggtcagg     1920

ccgggtccag cactgccgga tccgctccac catggagggc gggaccctga aatactactt     1980

gactgacaac ctcaccttca gcagcatcta tgccctcatc cagcactacc gcgagacgca     2040

cctgcgctgc gccgagttcg agctgcggct cacggaccct gtgcccaacc ccaaccccca     2100

cgagtccaag ccgtggtact atgacagcct gagccgcgga gaggcagagg acatgctgat     2160

gaggattccc cgggacgggg ccttcctgat ccggaagcga gaggggagcg actcctatgc     2220

catcaccttc agggctaggg gcaaggtaaa gcattgtcgc atcaaccggg acggccggca     2280

ctttgtgctg gggacctccg cctattttga gagtctggtg gagctcgtca gttactacga     2340

gaagcattca ctctaccgaa agatgagact gcgctacccc gtgacccccg agctcctgga     2400

gcgctacaat atggaaagag atataaactc cctctacgac gtcagcagaa tgtatgtgga     2460

tcccagtgaa atcaatccgt ccatgcctca gagaaccgtg aaagctctgt atgactacaa     2520

agccaagcga agcgatgagc tgagcttctg ccgtggtgcc ctcatccaca atgtctccaa     2580

ggagcccggg ggctggtgga aaggagacta tggaaccagg atccagcagt acttcccatc     2640

caactacgtc gaggacatct caactgcaga cttcgaggag ctagaaaagc agattattga     2700

agacaatccc ttagggtctc tttgcagagg aatattggac ctcaatacct ataacgtcgt     2760

gaaagcccct cagggaaaaa accagaagtc ctttgtcttc atcctggagc ccaagcagca     2820

gggcgatcct ccggtggagt ttgccacaga cagggtggag gagctctttg agtggtttca     2880

gagcatccga gagatcacct ggaagattga caccaaggag aacaacatga agtactggga     2940

gaagaaccag tccatcgcca tcgagctctc tgacctggtt gtctactgca aaccaaccag     3000

caaaaccaag gacaacttag aaaatcctga cttccgagaa atccgctcct ttgtggagac     3060

gaaggctgac agcatcatca gacagaagcc cgtcgacctc ctgaagtaca atcaaaaggg     3120

cctgacccgc gtctacccaa agggacaaag agttgactct tcaaactacg accccttccg     3180

cctctggctg tgcggttctc agatggtggc actcaatttc cagacggcag ataagtacat     3240

gcagatgaat cacgcattgt tttctctcaa tgggcgcacg ggctacgttc tgcagcctga     3300

gagcatgagg acagagaaat atgacccgat gccacccgag tcccagagga agatcctgat     3360

gacgctgaca gtcaaggttc tcggtgctcg ccatctcccc aaacttggac gaagtattgc     3420

ctgtcccttt gtagaagtgg agatctgtgg agccgagtat gacaacaaca agttcaagac     3480

gacggttgtg aatgataatg gcctcagccc tatctgggct ccaacacagg agaaggtgac     3540

atttgaaatt tatgacccaa acctggcatt tctgcgcttt gtggtttatg aagaagatat     3600

gttcagcgat cccaactttc ttgctcatgc cacttacccc attaaagcag tcaaatcagg     3660

attcaggtcc gttcctctga agaatgggta cagcgaggac atagagctgg cttccctcct     3720

ggttttctgt gagatgcggc cagtcctgga gagcgaagag gaactttact cctcctgtcg     3780

ccagctgagg aggcggcaag aagaactgaa caaccagctc tttctgtatg acacacacca     3840

gaacttgcgc aatgccaacc gggatgccct ggttaaagag ttcagtgtta atgagaacca     3900

gctccagctg taccaggaga aatgcaacaa gaggttaaga gagaagagag tcagcaacag     3960

caagttttac tcatagaagc tggggtatgt gtgtaagggt attgtgtgtg tgcgcatgtg     4020

tgtttgcatg taggagaacg tgccctattc acactctggg aagacgctaa tctgtgacat     4080

cttttcttca agcctgccat caaggacatt tcttaagacc caactggcat gagttggggt     4140

aatttcctat tattttcatc ttggacaact ttcttaactt atattcttta tagaggattc     4200

cccaaaatgt gctcctcatt tttggcctct catgttccaa acctcattga ataaaagcaa     4260

tgaaaacctt gaaaaaaaaa aaaaaaaaa                                       4289


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer

<400>  13
tgatgggctc caaatccctg                                                   20


<210>  14
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer

<400>  14
gaatgatggc accagcagc                                                    19


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer

<400>  15
aatccctgct tgcttccaca                                                   20


<210>  16
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer

<400>  16
ttgatgggct cagcactgg                                                    19


<210>  17
<211>  1265
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ser Thr Thr Val Asn Val Asp Ser Leu Ala Glu Tyr Glu Lys Ser 
1               5                   10                  15      


Gln Ile Lys Arg Ala Leu Glu Leu Gly Thr Val Met Thr Val Phe Ser 
            20                  25                  30          


Phe Arg Lys Ser Thr Pro Glu Arg Arg Thr Val Gln Val Ile Met Glu 
        35                  40                  45              


Thr Arg Gln Val Ala Trp Ser Lys Thr Ala Asp Lys Ile Glu Gly Phe 
    50                  55                  60                  


Leu Asp Ile Met Glu Ile Lys Glu Ile Arg Pro Gly Lys Asn Ser Lys 
65                  70                  75                  80  


Asp Phe Glu Arg Ala Lys Ala Val Arg Gln Lys Glu Asp Cys Cys Phe 
                85                  90                  95      


Thr Ile Leu Tyr Gly Thr Gln Phe Val Leu Ser Thr Leu Ser Leu Ala 
            100                 105                 110         


Ala Asp Ser Lys Glu Asp Ala Val Asn Trp Leu Ser Gly Leu Lys Ile 
        115                 120                 125             


Leu His Gln Glu Ala Met Asn Ala Ser Thr Pro Thr Ile Ile Glu Ser 
    130                 135                 140                 


Trp Leu Arg Lys Gln Ile Tyr Ser Val Asp Gln Thr Arg Arg Asn Ser 
145                 150                 155                 160 


Ile Ser Leu Arg Glu Leu Lys Thr Ile Leu Pro Leu Ile Asn Phe Lys 
                165                 170                 175     


Val Ser Ser Ala Lys Phe Leu Lys Asp Lys Phe Val Glu Ile Gly Ala 
            180                 185                 190         


His Lys Asp Glu Leu Ser Phe Glu Gln Phe His Leu Phe Tyr Lys Lys 
        195                 200                 205             


Leu Met Phe Glu Gln Gln Lys Ser Ile Leu Asp Glu Phe Lys Lys Asp 
    210                 215                 220                 


Ser Ser Val Phe Ile Leu Gly Asn Thr Asp Arg Pro Asp Ala Ser Ala 
225                 230                 235                 240 


Val Tyr Leu Arg Asp Phe Gln Arg Phe Leu Ile His Glu Gln Gln Glu 
                245                 250                 255     


His Trp Ala Gln Asp Leu Asn Lys Val Arg Glu Arg Met Thr Lys Phe 
            260                 265                 270         


Ile Asp Asp Thr Met Arg Glu Thr Ala Glu Pro Phe Leu Phe Val Asp 
        275                 280                 285             


Glu Phe Leu Thr Tyr Leu Phe Ser Arg Glu Asn Ser Ile Trp Asp Glu 
    290                 295                 300                 


Lys Tyr Asp Ala Val Asp Met Gln Asp Met Asn Asn Pro Leu Ser His 
305                 310                 315                 320 


Tyr Trp Ile Ser Ser Ser His Asn Thr Tyr Leu Thr Gly Asp Gln Leu 
                325                 330                 335     


Arg Ser Glu Ser Ser Pro Glu Ala Tyr Ile Arg Cys Leu Arg Met Gly 
            340                 345                 350         


Cys Arg Cys Ile Glu Leu Asp Cys Trp Asp Gly Pro Asp Gly Lys Pro 
        355                 360                 365             


Val Ile Tyr His Gly Trp Thr Arg Thr Thr Lys Ile Lys Phe Asp Asp 
    370                 375                 380                 


Val Val Gln Ala Ile Lys Asp His Ala Phe Val Thr Ser Ser Phe Pro 
385                 390                 395                 400 


Val Ile Leu Ser Ile Glu Glu His Cys Ser Val Glu Gln Gln Arg His 
                405                 410                 415     


Met Ala Lys Ala Phe Lys Glu Val Phe Gly Asp Leu Leu Leu Thr Lys 
            420                 425                 430         


Pro Thr Glu Ala Ser Ala Asp Gln Leu Pro Ser Pro Ser Gln Leu Arg 
        435                 440                 445             


Glu Lys Ile Ile Ile Lys His Lys Lys Leu Gly Pro Arg Gly Asp Val 
    450                 455                 460                 


Asp Val Asn Met Glu Asp Lys Lys Asp Glu His Lys Gln Gln Gly Glu 
465                 470                 475                 480 


Leu Tyr Met Trp Asp Ser Ile Asp Gln Lys Trp Thr Arg His Tyr Cys 
                485                 490                 495     


Ala Ile Ala Asp Ala Lys Leu Ser Phe Ser Asp Asp Ile Glu Gln Thr 
            500                 505                 510         


Met Glu Glu Glu Val Pro Gln Asp Ile Pro Pro Thr Glu Leu His Phe 
        515                 520                 525             


Gly Glu Lys Trp Phe His Lys Lys Val Glu Lys Arg Thr Ser Ala Glu 
    530                 535                 540                 


Lys Leu Leu Gln Glu Tyr Cys Met Glu Thr Gly Gly Lys Asp Gly Thr 
545                 550                 555                 560 


Phe Leu Val Arg Glu Ser Glu Thr Phe Pro Asn Asp Tyr Thr Leu Ser 
                565                 570                 575     


Phe Trp Arg Ser Gly Arg Val Gln His Cys Arg Ile Arg Ser Thr Met 
            580                 585                 590         


Glu Gly Gly Thr Leu Lys Tyr Tyr Leu Thr Asp Asn Leu Thr Phe Ser 
        595                 600                 605             


Ser Ile Tyr Ala Leu Ile Gln His Tyr Arg Glu Thr His Leu Arg Cys 
    610                 615                 620                 


Ala Glu Phe Glu Leu Arg Leu Thr Asp Pro Val Pro Asn Pro Asn Pro 
625                 630                 635                 640 


His Glu Ser Lys Pro Trp Tyr Tyr Asp Ser Leu Ser Arg Gly Glu Ala 
                645                 650                 655     


Glu Asp Met Leu Met Arg Ile Pro Trp Asp Gly Ala Phe Leu Ile Arg 
            660                 665                 670         


Lys Arg Glu Gly Ser Asp Ser Tyr Ala Ile Thr Phe Arg Ala Arg Gly 
        675                 680                 685             


Lys Val Lys His Cys Arg Ile Asn Arg Asp Gly Arg His Phe Val Leu 
    690                 695                 700                 


Gly Thr Ser Ala Tyr Phe Glu Ser Leu Val Glu Leu Val Ser Tyr Tyr 
705                 710                 715                 720 


Glu Lys His Ser Leu Tyr Arg Lys Met Arg Leu Arg Tyr Pro Val Thr 
                725                 730                 735     


Pro Glu Leu Leu Glu Arg Tyr Asn Met Glu Arg Asp Ile Asn Ser Leu 
            740                 745                 750         


Tyr Asp Val Ser Arg Met Tyr Val Asp Pro Ser Glu Ile Asn Pro Ser 
        755                 760                 765             


Met Pro Gln Arg Thr Val Lys Ala Leu Tyr Asp Tyr Lys Ala Lys Arg 
    770                 775                 780                 


Ser Asp Glu Leu Ser Phe Cys Arg Gly Ala Leu Ile His Asn Val Ser 
785                 790                 795                 800 


Lys Glu Pro Gly Gly Trp Trp Lys Gly Asp Tyr Gly Thr Arg Ile Gln 
                805                 810                 815     


Gln Tyr Phe Pro Ser Asn Tyr Val Glu Asp Ile Ser Thr Ala Asp Phe 
            820                 825                 830         


Glu Glu Leu Glu Lys Gln Ile Ile Glu Asp Asn Pro Leu Gly Ser Leu 
        835                 840                 845             


Cys Arg Gly Ile Leu Asp Leu Asn Thr Tyr Asn Val Val Lys Ala Pro 
    850                 855                 860                 


Gln Gly Lys Asn Gln Lys Ser Phe Val Phe Ile Leu Glu Pro Lys Gln 
865                 870                 875                 880 


Gln Gly Tyr Pro Pro Val Glu Phe Ala Thr Asp Arg Val Glu Glu Leu 
                885                 890                 895     


Phe Glu Trp Phe Gln Ser Ile Arg Glu Ile Thr Trp Lys Ile Asp Thr 
            900                 905                 910         


Lys Glu Asn Asn Met Lys Tyr Trp Glu Lys Asn Gln Ser Ile Ala Ile 
        915                 920                 925             


Glu Leu Ser Asp Leu Val Val Tyr Cys Lys Pro Thr Ser Lys Thr Lys 
    930                 935                 940                 


Asp Asn Leu Glu Asn Pro Asp Phe Arg Glu Ile Arg Ser Phe Val Glu 
945                 950                 955                 960 


Thr Lys Ala Asp Ser Ile Ile Arg Gln Lys Pro Val Asp Leu Leu Lys 
                965                 970                 975     


Tyr Asn Gln Lys Gly Leu Thr Arg Val Tyr Pro Lys Gly Gln Arg Val 
            980                 985                 990         


Asp Ser Ser Asn Tyr Asp Pro Phe  Arg Leu Trp Leu Cys  Gly Ser Gln 
        995                 1000                 1005             


Met Val  Ala Leu Asn Phe Gln  Thr Ala Asp Lys Tyr  Met Gln Met 
    1010                 1015                 1020             


Asn His  Ala Leu Phe Ser Leu  Asn Gly Arg Thr Gly  Tyr Val Leu 
    1025                 1030                 1035             


Gln Pro  Glu Ser Met Arg Thr  Glu Lys Tyr Asp Pro  Met Pro Pro 
    1040                 1045                 1050             


Glu Ser  Gln Arg Lys Ile Leu  Met Thr Leu Thr Val  Lys Val Leu 
    1055                 1060                 1065             


Gly Ala  Arg His Leu Pro Lys  Leu Gly Arg Ser Ile  Ala Cys Pro 
    1070                 1075                 1080             


Phe Val  Glu Val Glu Ile Cys  Gly Ala Glu Tyr Asp  Asn Asn Lys 
    1085                 1090                 1095             


Phe Lys  Thr Thr Val Val Asn  Asp Asn Gly Leu Ser  Pro Ile Trp 
    1100                 1105                 1110             


Ala Pro  Thr Gln Glu Lys Val  Thr Phe Glu Ile Tyr  Asp Pro Asn 
    1115                 1120                 1125             


Leu Ala  Phe Leu Arg Phe Val  Val Tyr Glu Glu Asp  Met Phe Ser 
    1130                 1135                 1140             


Asp Pro  Asn Phe Leu Ala His  Ala Thr Tyr Pro Ile  Lys Ala Val 
    1145                 1150                 1155             


Lys Ser  Gly Phe Arg Ser Val  Pro Leu Lys Asn Gly  Tyr Ser Glu 
    1160                 1165                 1170             


Asp Ile  Glu Leu Ala Ser Leu  Leu Val Phe Cys Glu  Met Arg Pro 
    1175                 1180                 1185             


Val Leu  Glu Ser Glu Glu Glu  Leu Tyr Ser Ser Cys  Arg Gln Leu 
    1190                 1195                 1200             


Arg Arg  Arg Gln Glu Glu Leu  Asn Asn Gln Leu Phe  Leu Tyr Asp 
    1205                 1210                 1215             


Thr His  Gln Asn Leu Arg Asn  Ala Asn Arg Asp Ala  Leu Val Lys 
    1220                 1225                 1230             


Glu Phe  Ser Val Asn Glu Asn  Gln Leu Gln Leu Tyr  Gln Glu Lys 
    1235                 1240                 1245             


Cys Asn  Lys Arg Leu Arg Glu  Lys Arg Val Ser Asn  Ser Lys Phe 
    1250                 1255                 1260             


Tyr Ser  
    1265 


<210>  18
<211>  1265
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ser Thr Thr Val Asn Val Asp Ser Leu Ala Glu Tyr Glu Lys Ser 
1               5                   10                  15      


Gln Ile Lys Arg Ala Leu Glu Leu Gly Thr Val Met Thr Val Phe Ser 
            20                  25                  30          


Phe Arg Lys Ser Thr Pro Glu Arg Arg Thr Val Gln Val Ile Met Glu 
        35                  40                  45              


Thr Arg Gln Val Ala Trp Ser Lys Thr Ala Asp Lys Ile Glu Gly Phe 
    50                  55                  60                  


Leu Asp Ile Met Glu Ile Lys Glu Ile Arg Pro Gly Lys Asn Ser Lys 
65                  70                  75                  80  


Asp Phe Glu Arg Ala Lys Ala Val Arg Gln Lys Glu Asp Cys Cys Phe 
                85                  90                  95      


Thr Ile Leu Tyr Gly Thr Gln Phe Val Leu Ser Thr Leu Ser Leu Ala 
            100                 105                 110         


Ala Asp Ser Lys Glu Asp Ala Val Asn Trp Leu Ser Gly Leu Lys Ile 
        115                 120                 125             


Leu His Gln Glu Ala Met Asn Ala Ser Thr Pro Thr Ile Ile Glu Ser 
    130                 135                 140                 


Trp Leu Arg Lys Gln Ile Tyr Ser Val Asp Gln Thr Arg Arg Asn Ser 
145                 150                 155                 160 


Ile Ser Leu Arg Glu Leu Lys Thr Ile Leu Pro Leu Ile Asn Phe Lys 
                165                 170                 175     


Val Ser Ser Ala Lys Phe Leu Lys Asp Lys Phe Val Glu Ile Gly Ala 
            180                 185                 190         


His Lys Asp Glu Leu Ser Phe Glu Gln Phe His Leu Phe Tyr Lys Lys 
        195                 200                 205             


Leu Met Phe Glu Gln Gln Lys Ser Ile Leu Asp Glu Phe Lys Lys Asp 
    210                 215                 220                 


Ser Ser Val Phe Ile Leu Gly Asn Thr Asp Arg Pro Asp Ala Ser Ala 
225                 230                 235                 240 


Val Tyr Leu Arg Asp Phe Gln Arg Phe Leu Ile His Glu Gln Gln Glu 
                245                 250                 255     


His Trp Ala Gln Asp Leu Asn Lys Val Arg Glu Arg Met Thr Lys Phe 
            260                 265                 270         


Ile Asp Asp Thr Met Arg Glu Thr Ala Glu Pro Phe Leu Phe Val Asp 
        275                 280                 285             


Glu Phe Leu Thr Tyr Leu Phe Ser Arg Glu Asn Ser Ile Trp Asp Glu 
    290                 295                 300                 


Lys Tyr Asp Ala Val Asp Met Gln Asp Met Asn Asn Pro Leu Ser His 
305                 310                 315                 320 


Tyr Trp Ile Ser Ser Ser His Asn Thr Tyr Leu Thr Gly Asp Gln Leu 
                325                 330                 335     


Arg Ser Glu Ser Ser Pro Glu Ala Tyr Ile Arg Cys Leu Arg Met Gly 
            340                 345                 350         


Cys Arg Cys Ile Glu Leu Asp Cys Trp Asp Gly Pro Asp Gly Lys Pro 
        355                 360                 365             


Val Ile Tyr His Gly Trp Thr Arg Thr Thr Lys Ile Lys Phe Asp Asp 
    370                 375                 380                 


Val Val Gln Ala Ile Lys Asp His Ala Phe Val Thr Ser Ser Phe Pro 
385                 390                 395                 400 


Val Ile Leu Ser Ile Glu Glu His Cys Ser Val Glu Gln Gln Arg His 
                405                 410                 415     


Met Ala Lys Ala Phe Lys Glu Val Phe Gly Asp Leu Leu Leu Thr Lys 
            420                 425                 430         


Pro Thr Glu Ala Ser Ala Asp Gln Leu Pro Ser Pro Ser Gln Leu Arg 
        435                 440                 445             


Glu Lys Ile Ile Ile Lys His Lys Lys Leu Gly Pro Arg Gly Asp Val 
    450                 455                 460                 


Asp Val Asn Met Glu Asp Lys Lys Asp Glu His Lys Gln Gln Gly Glu 
465                 470                 475                 480 


Leu Tyr Met Trp Asp Ser Ile Asp Gln Lys Trp Thr Arg His Tyr Cys 
                485                 490                 495     


Ala Ile Ala Asp Ala Lys Leu Ser Phe Ser Asp Asp Ile Glu Gln Thr 
            500                 505                 510         


Met Glu Glu Glu Val Pro Gln Asp Ile Pro Pro Thr Glu Leu His Phe 
        515                 520                 525             


Gly Glu Lys Trp Phe His Lys Lys Val Glu Lys Arg Thr Ser Ala Glu 
    530                 535                 540                 


Lys Leu Leu Gln Glu Tyr Cys Met Glu Thr Gly Gly Lys Asp Gly Thr 
545                 550                 555                 560 


Phe Leu Val Arg Glu Ser Glu Thr Phe Pro Asn Asp Tyr Thr Leu Ser 
                565                 570                 575     


Phe Trp Arg Ser Gly Arg Val Gln His Cys Arg Ile Arg Ser Thr Met 
            580                 585                 590         


Glu Gly Gly Thr Leu Lys Tyr Tyr Leu Thr Asp Asn Leu Thr Phe Ser 
        595                 600                 605             


Ser Ile Tyr Ala Leu Ile Gln His Tyr Arg Glu Thr His Leu Arg Cys 
    610                 615                 620                 


Ala Glu Phe Glu Leu Arg Leu Thr Asp Pro Val Pro Asn Pro Asn Pro 
625                 630                 635                 640 


His Glu Ser Lys Pro Trp Tyr Tyr Asp Ser Leu Ser Arg Gly Glu Ala 
                645                 650                 655     


Glu Asp Met Leu Met Arg Ile Pro Arg Asp Gly Ala Phe Leu Ile Arg 
            660                 665                 670         


Lys Arg Glu Gly Ser Asp Ser Tyr Ala Ile Thr Phe Arg Ala Arg Gly 
        675                 680                 685             


Lys Val Lys His Cys Arg Ile Asn Arg Asp Gly Arg His Phe Val Leu 
    690                 695                 700                 


Gly Thr Phe Ala Tyr Phe Glu Ser Leu Val Glu Leu Val Ser Tyr Tyr 
705                 710                 715                 720 


Glu Lys His Ser Leu Tyr Arg Lys Met Arg Leu Arg Tyr Pro Val Thr 
                725                 730                 735     


Pro Glu Leu Leu Glu Arg Tyr Asn Met Glu Arg Asp Ile Asn Ser Leu 
            740                 745                 750         


Tyr Asp Val Ser Arg Met Tyr Val Asp Pro Ser Glu Ile Asn Pro Ser 
        755                 760                 765             


Met Pro Gln Arg Thr Val Lys Ala Leu Tyr Asp Tyr Lys Ala Lys Arg 
    770                 775                 780                 


Ser Asp Glu Leu Ser Phe Cys Arg Gly Ala Leu Ile His Asn Val Ser 
785                 790                 795                 800 


Lys Glu Pro Gly Gly Trp Trp Lys Gly Asp Tyr Gly Thr Arg Ile Gln 
                805                 810                 815     


Gln Tyr Phe Pro Ser Asn Tyr Val Glu Asp Ile Ser Thr Ala Asp Phe 
            820                 825                 830         


Glu Glu Leu Glu Lys Gln Ile Ile Glu Asp Asn Pro Leu Gly Ser Leu 
        835                 840                 845             


Cys Arg Gly Ile Leu Asp Leu Asn Thr Tyr Asn Val Val Lys Ala Pro 
    850                 855                 860                 


Gln Gly Lys Asn Gln Lys Ser Phe Val Phe Ile Leu Glu Pro Lys Gln 
865                 870                 875                 880 


Gln Gly Tyr Pro Pro Val Glu Phe Ala Thr Asp Arg Val Glu Glu Leu 
                885                 890                 895     


Phe Glu Trp Phe Gln Ser Ile Arg Glu Ile Thr Trp Lys Ile Asp Thr 
            900                 905                 910         


Lys Glu Asn Asn Met Lys Tyr Trp Glu Lys Asn Gln Ser Ile Ala Ile 
        915                 920                 925             


Glu Leu Ser Asp Leu Val Val Tyr Cys Lys Pro Thr Ser Lys Thr Lys 
    930                 935                 940                 


Asp Asn Leu Glu Asn Pro Asp Phe Arg Glu Ile Arg Ser Phe Val Glu 
945                 950                 955                 960 


Thr Lys Ala Asp Ser Ile Ile Arg Gln Lys Pro Val Asp Leu Leu Lys 
                965                 970                 975     


Tyr Asn Gln Lys Gly Leu Thr Arg Val Tyr Pro Lys Gly Gln Arg Val 
            980                 985                 990         


Asp Ser Ser Asn Tyr Asp Pro Phe  Arg Leu Trp Leu Cys  Gly Ser Gln 
        995                 1000                 1005             


Met Val  Ala Leu Asn Phe Gln  Thr Ala Asp Lys Tyr  Met Gln Met 
    1010                 1015                 1020             


Asn His  Ala Leu Phe Ser Leu  Asn Gly Arg Thr Gly  Tyr Val Leu 
    1025                 1030                 1035             


Gln Pro  Glu Ser Met Arg Thr  Glu Lys Tyr Asp Pro  Met Pro Pro 
    1040                 1045                 1050             


Glu Ser  Gln Arg Lys Ile Leu  Met Thr Leu Thr Val  Lys Val Leu 
    1055                 1060                 1065             


Gly Ala  Arg His Leu Pro Lys  Leu Gly Arg Ser Ile  Ala Cys Pro 
    1070                 1075                 1080             


Phe Val  Glu Val Glu Ile Cys  Gly Ala Glu Tyr Asp  Asn Asn Lys 
    1085                 1090                 1095             


Phe Lys  Thr Thr Val Val Asn  Asp Asn Gly Leu Ser  Pro Ile Trp 
    1100                 1105                 1110             


Ala Pro  Thr Gln Glu Lys Val  Thr Phe Glu Ile Tyr  Asp Pro Asn 
    1115                 1120                 1125             


Leu Ala  Phe Leu Arg Phe Val  Val Tyr Glu Glu Asp  Met Phe Ser 
    1130                 1135                 1140             


Asp Pro  Asn Phe Leu Ala His  Ala Thr Tyr Pro Ile  Lys Ala Val 
    1145                 1150                 1155             


Lys Ser  Gly Phe Arg Ser Val  Pro Leu Lys Asn Gly  Tyr Ser Glu 
    1160                 1165                 1170             


Asp Ile  Glu Leu Ala Ser Leu  Leu Val Phe Cys Glu  Met Arg Pro 
    1175                 1180                 1185             


Val Leu  Glu Ser Glu Glu Glu  Leu Tyr Ser Ser Cys  Arg Gln Leu 
    1190                 1195                 1200             


Arg Arg  Arg Gln Glu Glu Leu  Asn Asn Gln Leu Phe  Leu Tyr Asp 
    1205                 1210                 1215             


Thr His  Gln Asn Leu Arg Asn  Ala Asn Arg Asp Ala  Leu Val Lys 
    1220                 1225                 1230             


Glu Phe  Ser Val Asn Glu Asn  Gln Leu Gln Leu Tyr  Gln Glu Lys 
    1235                 1240                 1245             


Cys Asn  Lys Arg Leu Arg Glu  Lys Arg Val Ser Asn  Ser Lys Phe 
    1250                 1255                 1260             


Tyr Ser  
    1265 


<210>  19
<211>  1154
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Pro Gly Gly Gly Pro Glu Met Asp Asp Tyr Met Glu Thr Leu Lys 
1               5                   10                  15      


Asp Glu Glu Asp Ala Leu Trp Glu Asn Val Glu Cys Asn Arg His Met 
            20                  25                  30          


Leu Ser Arg Tyr Ile Asn Pro Ala Lys Leu Thr Pro Tyr Leu Arg Gln 
        35                  40                  45              


Cys Lys Val Ile Asp Glu Gln Asp Glu Asp Glu Val Leu Asn Ala Pro 
    50                  55                  60                  


Met Leu Pro Ser Lys Ile Asn Arg Ala Gly Arg Leu Leu Asp Ile Leu 
65                  70                  75                  80  


His Thr Lys Gly Gln Arg Gly Tyr Val Val Phe Leu Glu Ser Leu Glu 
                85                  90                  95      


Phe Tyr Tyr Pro Glu Leu Tyr Lys Leu Val Thr Gly Lys Glu Pro Thr 
            100                 105                 110         


Arg Arg Phe Ser Thr Ile Val Val Glu Glu Gly His Glu Gly Leu Thr 
        115                 120                 125             


His Phe Leu Met Asn Glu Val Ile Lys Leu Gln Gln Gln Met Lys Ala 
    130                 135                 140                 


Lys Asp Leu Gln Arg Cys Glu Leu Leu Ala Arg Leu Arg Gln Leu Glu 
145                 150                 155                 160 


Asp Glu Lys Lys Gln Met Thr Leu Thr Arg Val Glu Leu Leu Thr Phe 
                165                 170                 175     


Gln Glu Arg Tyr Tyr Lys Met Lys Glu Glu Arg Asp Ser Tyr Asn Asp 
            180                 185                 190         


Glu Leu Val Lys Val Lys Asp Asp Asn Tyr Asn Leu Ala Met Arg Tyr 
        195                 200                 205             


Ala Gln Leu Ser Glu Glu Lys Asn Met Ala Val Met Arg Ser Arg Asp 
    210                 215                 220                 


Leu Gln Leu Glu Ile Asp Gln Leu Lys His Arg Leu Asn Lys Met Glu 
225                 230                 235                 240 


Glu Glu Cys Lys Leu Glu Arg Asn Gln Ser Leu Lys Leu Lys Asn Asp 
                245                 250                 255     


Ile Glu Asn Arg Pro Lys Lys Glu Gln Val Leu Glu Leu Glu Arg Glu 
            260                 265                 270         


Asn Glu Met Leu Lys Thr Lys Asn Gln Glu Leu Gln Ser Ile Ile Gln 
        275                 280                 285             


Ala Gly Lys Arg Ser Leu Pro Asp Ser Asp Lys Ala Ile Leu Asp Ile 
    290                 295                 300                 


Leu Glu His Asp Arg Lys Glu Ala Leu Glu Asp Arg Gln Glu Leu Val 
305                 310                 315                 320 


Asn Arg Ile Tyr Asn Leu Gln Glu Glu Ala Arg Gln Ala Glu Glu Leu 
                325                 330                 335     


Arg Asp Lys Tyr Leu Glu Glu Lys Glu Asp Leu Glu Leu Lys Cys Ser 
            340                 345                 350         


Thr Leu Gly Lys Asp Cys Glu Met Tyr Lys His Arg Met Asn Thr Val 
        355                 360                 365             


Met Leu Gln Leu Glu Glu Val Glu Arg Glu Arg Asp Gln Ala Phe His 
    370                 375                 380                 


Ser Arg Asp Glu Ala Gln Thr Gln Tyr Ser Gln Cys Leu Ile Glu Lys 
385                 390                 395                 400 


Asp Lys Tyr Arg Lys Gln Ile Arg Glu Leu Glu Glu Lys Asn Asp Glu 
                405                 410                 415     


Met Arg Ile Glu Met Val Arg Arg Glu Ala Cys Ile Val Asn Leu Glu 
            420                 425                 430         


Ser Lys Leu Arg Arg Leu Ser Lys Asp Ser Asn Asn Leu Asp Gln Ser 
        435                 440                 445             


Leu Pro Arg Asn Leu Pro Val Thr Ile Ile Ser Gln Asp Phe Gly Asp 
    450                 455                 460                 


Ala Ser Pro Arg Thr Asn Gly Gln Glu Ala Asp Asp Ser Ser Thr Ser 
465                 470                 475                 480 


Glu Glu Ser Pro Glu Asp Ser Lys Tyr Phe Leu Pro Tyr His Pro Pro 
                485                 490                 495     


Gln Arg Arg Met Asn Leu Lys Gly Ile Gln Leu Gln Arg Ala Lys Ser 
            500                 505                 510         


Pro Ile Ser Leu Lys Arg Thr Ser Asp Phe Gln Ala Lys Gly His Glu 
        515                 520                 525             


Glu Glu Gly Thr Asp Ala Ser Pro Ser Ser Cys Gly Ser Leu Pro Ile 
    530                 535                 540                 


Thr Asn Ser Phe Thr Lys Met Gln Pro Pro Arg Ser Arg Ser Ser Ile 
545                 550                 555                 560 


Met Ser Ile Thr Ala Glu Pro Pro Gly Asn Asp Ser Ile Val Arg Arg 
                565                 570                 575     


Tyr Lys Glu Asp Ala Pro His Arg Ser Thr Val Glu Glu Asp Asn Asp 
            580                 585                 590         


Ser Gly Gly Phe Asp Ala Leu Asp Leu Asp Asp Asp Ser His Glu Arg 
        595                 600                 605             


Tyr Ser Phe Gly Pro Ser Ser Ile His Ser Ser Ser Ser Ser His Gln 
    610                 615                 620                 


Ser Glu Gly Leu Asp Ala Tyr Asp Leu Glu Gln Val Asn Leu Met Phe 
625                 630                 635                 640 


Arg Lys Phe Ser Leu Glu Arg Pro Phe Arg Pro Ser Val Thr Ser Val 
                645                 650                 655     


Gly His Val Arg Gly Pro Gly Pro Ser Val Gln His Thr Thr Leu Asn 
            660                 665                 670         


Gly Asp Ser Leu Thr Ser Gln Leu Thr Leu Leu Gly Gly Asn Ala Arg 
        675                 680                 685             


Gly Ser Phe Val His Ser Val Lys Pro Gly Ser Leu Ala Glu Lys Ala 
    690                 695                 700                 


Gly Leu Arg Glu Gly His Gln Leu Leu Leu Leu Glu Gly Cys Ile Arg 
705                 710                 715                 720 


Gly Glu Arg Gln Ser Val Pro Leu Asp Thr Cys Thr Lys Glu Glu Ala 
                725                 730                 735     


His Trp Thr Ile Gln Arg Cys Ser Gly Pro Val Thr Leu His Tyr Lys 
            740                 745                 750         


Val Asn His Glu Gly Tyr Arg Lys Leu Val Lys Asp Met Glu Asp Gly 
        755                 760                 765             


Leu Ile Thr Ser Gly Asp Ser Phe Tyr Ile Arg Leu Asn Leu Asn Ile 
    770                 775                 780                 


Ser Ser Gln Leu Asp Ala Cys Thr Met Ser Leu Lys Cys Asp Asp Val 
785                 790                 795                 800 


Val His Val Arg Asp Thr Met Tyr Gln Asp Arg His Glu Trp Leu Cys 
                805                 810                 815     


Ala Arg Val Asp Pro Phe Thr Asp His Asp Leu Asp Met Gly Thr Ile 
            820                 825                 830         


Pro Ser Tyr Ser Arg Ala Gln Gln Leu Leu Leu Val Lys Leu Gln Arg 
        835                 840                 845             


Leu Met His Arg Gly Ser Arg Glu Glu Val Asp Gly Thr His His Thr 
    850                 855                 860                 


Leu Arg Ala Leu Arg Asn Thr Leu Gln Pro Glu Glu Ala Leu Ser Thr 
865                 870                 875                 880 


Ser Asp Pro Arg Val Ser Pro Arg Leu Ser Arg Ala Ser Phe Leu Phe 
                885                 890                 895     


Gly Gln Leu Leu Gln Phe Val Ser Arg Ser Glu Asn Lys Tyr Lys Arg 
            900                 905                 910         


Met Asn Ser Asn Glu Arg Val Arg Ile Ile Ser Gly Ser Pro Leu Gly 
        915                 920                 925             


Ser Leu Ala Arg Ser Ser Leu Asp Ala Thr Lys Leu Leu Thr Glu Lys 
    930                 935                 940                 


Gln Glu Glu Leu Asp Pro Glu Ser Glu Leu Gly Lys Asn Leu Ser Leu 
945                 950                 955                 960 


Ile Pro Tyr Ser Leu Val Arg Ala Phe Tyr Cys Glu Arg Arg Arg Pro 
                965                 970                 975     


Val Leu Phe Thr Pro Thr Val Leu Ala Lys Thr Leu Val Gln Arg Leu 
            980                 985                 990         


Leu Asn Ser Gly Gly Ala Met Glu  Phe Thr Ile Cys Lys  Ser Asp Ile 
        995                 1000                 1005             


Val Thr  Arg Asp Glu Phe Leu  Arg Arg Gln Lys Thr  Glu Thr Ile 
    1010                 1015                 1020             


Ile Tyr  Ser Arg Glu Lys Asn  Pro Asn Ala Phe Glu  Cys Ile Ala 
    1025                 1030                 1035             


Pro Ala  Asn Ile Glu Ala Val  Ala Ala Lys Asn Lys  His Cys Leu 
    1040                 1045                 1050             


Leu Glu  Ala Gly Ile Gly Cys  Thr Arg Asp Leu Ile  Lys Ser Asn 
    1055                 1060                 1065             


Ile Tyr  Pro Ile Val Leu Phe  Ile Arg Val Cys Glu  Lys Asn Ile 
    1070                 1075                 1080             


Lys Arg  Phe Arg Lys Leu Leu  Pro Arg Pro Glu Thr  Glu Glu Glu 
    1085                 1090                 1095             


Phe Leu  Arg Val Cys Arg Leu  Lys Glu Lys Glu Leu  Glu Ala Leu 
    1100                 1105                 1110             


Pro Cys  Leu Tyr Ala Thr Val  Glu Pro Asp Met Trp  Gly Ser Val 
    1115                 1120                 1125             


Glu Glu  Leu Leu Arg Val Val  Lys Asp Lys Ile Gly  Glu Glu Gln 
    1130                 1135                 1140             


Arg Lys  Thr Ile Trp Val Asp  Glu Asp Gln Leu 
    1145                 1150                 


<210>  20
<211>  1155
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Pro Gly Gly Gly Pro Glu Met Asp Asp Tyr Met Glu Thr Leu Lys 
1               5                   10                  15      


Asp Glu Glu Asp Ala Leu Trp Glu Asn Val Glu Cys Asn Arg His Met 
            20                  25                  30          


Leu Ser Arg Tyr Ile Asn Pro Ala Lys Leu Thr Pro Tyr Leu Arg Gln 
        35                  40                  45              


Cys Lys Val Ile Asp Glu Gln Asp Glu Asp Glu Val Leu Asn Ala Pro 
    50                  55                  60                  


Met Leu Pro Ser Lys Ile Asn Arg Ala Gly Arg Leu Leu Asp Ile Leu 
65                  70                  75                  80  


His Thr Lys Gly Gln Arg Gly Tyr Val Val Phe Leu Glu Ser Leu Glu 
                85                  90                  95      


Phe Tyr Tyr Pro Glu Leu Tyr Lys Leu Val Thr Gly Lys Glu Pro Thr 
            100                 105                 110         


Arg Arg Phe Ser Thr Ile Val Val Glu Glu Gly His Glu Gly Leu Thr 
        115                 120                 125             


His Phe Leu Met Asn Glu Val Ile Lys Leu Gln Gln Gln Met Lys Ala 
    130                 135                 140                 


Lys Asp Leu Gln Arg Cys Glu Leu Leu Ala Arg Leu Arg Gln Leu Glu 
145                 150                 155                 160 


Asp Glu Lys Lys Gln Met Thr Leu Thr Arg Val Glu Leu Leu Thr Phe 
                165                 170                 175     


Gln Glu Arg Tyr Tyr Lys Met Lys Glu Glu Arg Asp Ser Tyr Asn Asp 
            180                 185                 190         


Glu Leu Val Lys Val Lys Asp Asp Asn Tyr Asn Leu Ala Met Arg Tyr 
        195                 200                 205             


Ala Gln Leu Ser Glu Glu Lys Asn Met Ala Val Met Arg Ser Arg Asp 
    210                 215                 220                 


Leu Gln Leu Glu Ile Asp Gln Leu Leu Lys His Arg Leu Asn Lys Met 
225                 230                 235                 240 


Glu Glu Glu Cys Lys Leu Glu Arg Asn Gln Ser Leu Lys Leu Lys Asn 
                245                 250                 255     


Asp Ile Glu Asn Arg Pro Lys Lys Glu Gln Val Leu Glu Leu Glu Arg 
            260                 265                 270         


Glu Asn Glu Met Leu Lys Thr Lys Asn Gln Glu Leu Gln Ser Ile Ile 
        275                 280                 285             


Gln Ala Gly Lys Arg Ser Leu Pro Asp Ser Asp Lys Ala Ile Leu Asp 
    290                 295                 300                 


Ile Leu Glu His Asp Arg Lys Glu Ala Leu Glu Asp Arg Gln Glu Leu 
305                 310                 315                 320 


Val Asn Arg Ile Tyr Asn Leu Gln Glu Glu Ala Arg Gln Ala Glu Glu 
                325                 330                 335     


Leu Arg Asp Lys Tyr Leu Glu Glu Lys Glu Asp Leu Glu Leu Lys Cys 
            340                 345                 350         


Ser Thr Leu Gly Lys Asp Cys Glu Met Tyr Lys His Arg Met Asn Thr 
        355                 360                 365             


Val Met Leu Gln Leu Glu Glu Val Glu Arg Glu Arg Asp Gln Ala Phe 
    370                 375                 380                 


His Ser Arg Asp Glu Ala Gln Thr Gln Tyr Ser Gln Cys Leu Ile Glu 
385                 390                 395                 400 


Lys Asp Lys Tyr Arg Lys Gln Ile Arg Glu Leu Glu Glu Lys Asn Asp 
                405                 410                 415     


Glu Met Arg Ile Glu Met Val Arg Arg Glu Ala Cys Ile Val Asn Leu 
            420                 425                 430         


Glu Ser Lys Leu Arg Arg Leu Ser Lys Asp Ser Asn Asn Leu Asp Gln 
        435                 440                 445             


Ser Leu Pro Arg Asn Leu Pro Val Thr Ile Ile Ser Gln Asp Phe Gly 
    450                 455                 460                 


Asp Ala Ser Pro Arg Thr Asn Gly Gln Glu Ala Asp Asp Ser Ser Thr 
465                 470                 475                 480 


Ser Glu Glu Ser Pro Glu Asp Ser Lys Tyr Phe Leu Pro Tyr His Pro 
                485                 490                 495     


Pro Gln Arg Arg Met Asn Leu Lys Gly Ile Gln Leu Gln Arg Ala Lys 
            500                 505                 510         


Ser Pro Ile Ser Leu Lys Arg Thr Ser Asp Phe Gln Ala Lys Gly His 
        515                 520                 525             


Glu Glu Glu Gly Thr Asp Ala Ser Pro Ser Ser Cys Gly Ser Leu Pro 
    530                 535                 540                 


Ile Thr Asn Ser Phe Thr Lys Met Gln Pro Pro Arg Ser Arg Ser Ser 
545                 550                 555                 560 


Ile Met Ser Ile Thr Ala Glu Pro Pro Gly Asn Asp Ser Ile Val Arg 
                565                 570                 575     


Arg Tyr Lys Glu Asp Ala Pro His Arg Ser Thr Val Glu Glu Asp Asn 
            580                 585                 590         


Asp Ser Gly Gly Phe Asp Ala Leu Asp Leu Asp Asp Asp Ser His Glu 
        595                 600                 605             


Arg Tyr Ser Phe Gly Pro Ser Ser Ile His Ser Ser Ser Ser Ser His 
    610                 615                 620                 


Gln Ser Glu Gly Leu Asp Ala Tyr Asp Leu Glu Gln Val Asn Leu Met 
625                 630                 635                 640 


Phe Arg Lys Phe Ser Leu Glu Arg Pro Phe Arg Pro Ser Val Thr Ser 
                645                 650                 655     


Val Gly His Val Arg Gly Pro Gly Pro Ser Val Gln His Thr Thr Leu 
            660                 665                 670         


Asn Gly Asp Ser Leu Thr Ser Gln Leu Thr Leu Leu Gly Gly Asn Ala 
        675                 680                 685             


Arg Gly Ser Phe Val His Ser Val Lys Pro Gly Ser Leu Ala Glu Lys 
    690                 695                 700                 


Ala Gly Leu Arg Glu Gly His Gln Leu Leu Leu Leu Glu Gly Cys Ile 
705                 710                 715                 720 


Arg Gly Glu Arg Gln Ser Val Pro Leu Asp Thr Cys Thr Lys Glu Glu 
                725                 730                 735     


Ala His Trp Thr Ile Gln Arg Cys Ser Gly Pro Val Thr Leu His Tyr 
            740                 745                 750         


Lys Val Asn His Glu Gly Tyr Arg Lys Leu Val Lys Asp Met Glu Asp 
        755                 760                 765             


Gly Leu Ile Thr Ser Gly Asp Ser Phe Tyr Ile Arg Leu Asn Leu Asn 
    770                 775                 780                 


Ile Ser Ser Gln Leu Asp Ala Cys Thr Met Ser Leu Lys Cys Asp Asp 
785                 790                 795                 800 


Val Val His Val Arg Asp Thr Met Tyr Gln Asp Arg His Glu Trp Leu 
                805                 810                 815     


Cys Ala Arg Val Asp Pro Phe Thr Asp His Asp Leu Asp Met Gly Thr 
            820                 825                 830         


Ile Pro Ser Tyr Ser Arg Ala Gln Gln Leu Leu Leu Val Lys Leu Gln 
        835                 840                 845             


Arg Leu Met His Arg Gly Ser Arg Glu Glu Val Asp Gly Thr His His 
    850                 855                 860                 


Thr Leu Arg Ala Leu Arg Asn Thr Leu Gln Pro Glu Glu Ala Leu Ser 
865                 870                 875                 880 


Thr Ser Asp Pro Arg Val Ser Pro Arg Leu Ser Arg Ala Ser Phe Leu 
                885                 890                 895     


Phe Gly Gln Leu Leu Gln Phe Val Ser Arg Ser Glu Asn Lys Tyr Lys 
            900                 905                 910         


Arg Met Asn Ser Asn Glu Arg Val Arg Ile Ile Ser Gly Ser Pro Leu 
        915                 920                 925             


Gly Ser Leu Ala Arg Ser Ser Leu Asp Ala Thr Lys Leu Leu Thr Glu 
    930                 935                 940                 


Lys Gln Glu Glu Leu Asp Pro Glu Ser Glu Leu Gly Lys Asn Leu Ser 
945                 950                 955                 960 


Leu Ile Pro Tyr Ser Leu Val Arg Ala Phe Tyr Cys Glu Arg Arg Arg 
                965                 970                 975     


Pro Val Leu Phe Thr Pro Thr Val Leu Ala Lys Thr Leu Val Gln Arg 
            980                 985                 990         


Leu Leu Asn Ser Gly Gly Ala Met  Glu Phe Thr Ile Cys  Lys Ser Asp 
        995                 1000                 1005             


Ile Val  Thr Arg Asp Glu Phe  Leu Arg Arg Gln Lys  Thr Glu Thr 
    1010                 1015                 1020             


Ile Ile  Tyr Ser Arg Glu Lys  Asn Pro Asn Ala Phe  Glu Cys Ile 
    1025                 1030                 1035             


Ala Pro  Ala Asn Ile Glu Ala  Val Ala Ala Lys Asn  Lys His Cys 
    1040                 1045                 1050             


Leu Leu  Glu Ala Gly Ile Gly  Cys Thr Arg Asp Leu  Ile Lys Ser 
    1055                 1060                 1065             


Asn Ile  Tyr Pro Ile Val Leu  Phe Ile Arg Val Cys  Glu Lys Asn 
    1070                 1075                 1080             


Ile Lys  Arg Phe Arg Lys Leu  Leu Pro Arg Pro Glu  Thr Glu Glu 
    1085                 1090                 1095             


Glu Phe  Leu Arg Val Cys Arg  Leu Lys Glu Lys Glu  Leu Glu Ala 
    1100                 1105                 1110             


Leu Pro  Cys Leu Tyr Ala Thr  Val Glu Pro Asp Met  Trp Gly Ser 
    1115                 1120                 1125             


Val Glu  Glu Leu Leu Arg Val  Val Lys Asp Lys Ile  Gly Glu Glu 
    1130                 1135                 1140             


Gln Arg  Lys Thr Ile Trp Val  Asp Glu Asp Gln Leu  
    1145                 1150                 1155 


<210>  21
<211>  1977
<212>  DNA
<213>  Homo sapiens

<400>  21
atggccgcag tgattctgga gagcatcttt ctgaagcgat cccaacagaa aaagaaaaca       60

tcacctctaa acttcaagaa gcgcctgttt ctcttgaccg tgcacaaact ctcctactat      120

gagtatgact ttgaacgtgg gagaagaggc agtaagaagg gttcaataga tgttgagaag      180

atcacttgtg ttgaaacagt ggttcctgaa aaaaatcctc ctccagaaag acagattccg      240

agaagaggtg aagagtccag tgaaatggag caaatttcaa tcattgaaag gttcccttat      300

cccttccagg ttgtatatga tgaagggcct ctctacgtct tctccccaac tgaagaacta      360

aggaagcggt ggattcacca gctcaaaaac gtaatccggt acaacagtga tctggttcag      420

aaatatcacc cttgcttctg gatcgatggg cagtatctct gctgctctca gacagccaaa      480

aatgctatgg gctgccaaat tttggagaac aggaatggaa gcttaaaacc tgggagttct      540

caccggaaga caaaaaagcc tcttccccca acgcctgagg aggaccagat cttgaaaaag      600

ccactaccgc ctgagccagc agcagcacca gtctccacaa gtgagctgaa aaaggttgtg      660

gccctttatg attacatgcc aatgaatgca aatgatctac agctgcggaa gggtgatgaa      720

tattttatct tggaggaaag caacttacca tggtggagag cacgagataa aaatgggcag      780

gaaggctaca ttcctagtaa ctatgtcact gaagcagaag actccataga aatgtatgag      840

tggtattcca aacacatgac tcggagtcag gctgagcaac tgctaaagca agaggggaaa      900

gaaggaggtt tcattgtcag agactccagc aaagctggca aatatacagt gtctgtgttt      960

gctaaatcca caggggaccc tcaaggggtg atacgtcatt atgttgtgtg ttccacacct     1020

cagagccagt attacctggc tgagaagcac cttttcagca ccatccctga gctcattaac     1080

taccatcagc acaactctgc aggactcata tccaggctca aatatccagt gtctcaacaa     1140

aacaagaatg caccttccac tgcaggcctg ggatacggat catgggaaat tgatccaaag     1200

gacctgacct tcttgaagga gctggggact ggacaatttg gggtagtgaa gtatgggaaa     1260

tggagaggcc agtacgacgt ggccatcaag atgatcaaag aaggctccat gtctgaagat     1320

gaattcattg aagaagccaa agtcatgatg aatctttccc atgagaagct ggtgcagttg     1380

tatggcgtct gcaccaagca gcgccccatc ttcatcatca ctgagtacat ggccaatggc     1440

tgcctcctga actacctgag ggagatgcgc caccgcttcc agactcagca gctgctagag     1500

atgtgcaagg atgtctgtga agccatggaa tacctggagt caaagcagtt ccttcaccga     1560

gacctggcag ctcgaaactg tttggtaaac gatcaaggag ttgttaaagt atctgatttc     1620

ggcctgtcca ggtatgtcct ggatgatgaa tacacaagct cagtaggctc caaatttcca     1680

gtccggtggt ccccaccgga agtcctgatg tatagcaagt tcagcagcaa atctgacatt     1740

tgggcttttg gggttttgat gtgggaaatt tactccctgg ggaagatgcc atatgagaga     1800

tttactaaca gtgagactgc tgaacacatt gcccaaggcc tacgtctcta caggcctcat     1860

ctggcttcag agaaggtata taccatcatg tacagttgct ggcatgagaa agcagatgag     1920

cgtcccactt tcaaaattct tctgagcaat attctagatg tcatggatga agaatcc        1977


<210>  22
<211>  1977
<212>  DNA
<213>  Homo sapiens

<400>  22
atggccgcag tgattctgga gagcatcttt ctgaagcgat cccaacagaa aaagaaaaca       60

tcacctctaa acttcaagaa gcgcctgttt ctcttgaccg tgcacaaact ctcctactat      120

gagtatgact ttgaacgtgg gagaagaggc agtaagaagg gttcaataga tgttgagaag      180

atcacttgtg ttgaaacagt ggttcctgaa aaaaatcctc ctccagaaag acagattccg      240

agaagaggtg aagagtccag tgaaatggag caaatttcaa tcattgaaag gttcccttat      300

cccttccagg ttgtatatga tgaagggcct ctctacgtct tctccccaac tgaagaacta      360

aggaagcggt ggattcacca gctcaaaaac gtaatccggt acaacagtga tctggttcag      420

aaatatcacc cttgcttctg gatcgatggg cagtatctct gctgctctca gacagccaaa      480

aatgctatgg gctgccaaat tttggagaac aggaatggaa gcttaaaacc tgggagttct      540

caccggaaga caaaaaagcc tcttccccca acgcctgagg aggaccagat cttgaaaaag      600

ccactaccgc ctgagccagc agcagcacca gtctccacaa gtgagctgaa aaaggttgtg      660

gccctttatg attacatgcc aatgaatgca aatgatctac agctgcggaa gggtgatgaa      720

tattttatct tggaggaaag caacttacca tggtggagag cacgagataa aaatgggcag      780

gaaggctaca ttcctagtaa ctatgtcact gaagcagaag actccataga aatgtatgag      840

tggtattcca aacacatgac tcggagtcag gctgagcaac tgctaaagca agaggggaaa      900

gaaggaggtt tcattgtcag agactccagc aaagctggca aatatacagt gtctgtgttt      960

gctaaatcca caggggaccc tcaaggggtg atacgtcatt atgttgtgtg ttccacacct     1020

cagagccagt attacctggc tgagaagcac cttttcagca ccatccctga gctcattaac     1080

taccatcagc acaactctgc aggactcata tccaggctca aatatccagt gtctcaacaa     1140

aacaagaatg caccttccac tgcaggcctg ggatacggat catgggaaat tgatccaaag     1200

gacctgacct tcttgaagga gctggggact ggacaatttg gggtagtgaa gtatgggaaa     1260

tggagaggcc agtacgacgt ggccatcaag atgatcaaag aaggctccat gtctgaagat     1320

gaattcattg aagaagccaa agtcatgatg aatctttccc atgagaagct ggtgcagttg     1380

tatggcgtct gcaccaagca gcgccccatc ttcatcatca ctgagtacat ggccaatggc     1440

agcctcctga actacctgag ggagatgcgc caccgcttcc agactcagca gctgctagag     1500

atgtgcaagg atgtctgtga agccatggaa tacctggagt caaagcagtt ccttcaccga     1560

gacctggcag ctcgaaactg tttggtaaac gatcaaggag ttgttaaagt atctgatttc     1620

ggcctgtcca ggtatgtcct ggatgatgaa tacacaagct cagtaggctc caaatttcca     1680

gtccggtggt ccccaccgga agtcctgatg tatagcaagt tcagcagcaa atctgacatt     1740

tgggcttttg gggttttgat gtgggaaatt tactccctgg ggaagatgcc atatgagaga     1800

tttactaaca gtgagactgc tgaacacatt gcccaaggcc tacgtctcta caggcctcat     1860

ctggcttcag agaaggtata taccatcatg tacagttgtt ggcatgagaa agcagatgag     1920

cgtcccactt tcaaaattct tctgagcaat attctagatg tcatggatga agaatcc        1977


<210>  23
<211>  1977
<212>  DNA
<213>  Homo sapiens

<400>  23
atggccgcag tgattctgga gagcatcttt ctgaagcgat cccaacagaa aaagaaaaca       60

tcacctctaa acttcaagaa gcgcctgttt ctcttgaccg tgcacaaact ctcctactat      120

gagtatgact ttgaacgtgg gagaagaggc agtaagaagg gttcaataga tgttgagaag      180

atcacttgtg ttgaaacagt ggttcctgaa aaaaatcctc ctccagaaag acagattccg      240

agaagaggtg aagagtccag tgaaatggag caaatttcaa tcattgaaag gttcccttat      300

cccttccagg ttgtatatga tgaagggcct ctctacgtct tctccccaac tgaagaacta      360

aggaagcggt ggattcacca gctcaaaaac gtaatccggt acaacagtga tctggttcag      420

aaatatcacc cttgcttctg gatcgatggg cagtatctct gctgctctca gacagccaaa      480

aatgctatgg gctgccaaat tttggagaac aggaatggaa gcttaaaacc tgggagttct      540

caccggaaga caaaaaagcc tcttccccca acgcctgagg aggaccagat cttgaaaaag      600

ccactaccgc ctgagccagc agcagcacca gtctccacaa gtgagctgaa aaaggttgtg      660

gccctttatg attacatgcc aatgaatgca aatgatctac agctgcggaa gggtgatgaa      720

tattttatct tggaggaaag caacttacca tggtggagag cacgagataa aaatgggcag      780

gaaggctaca ttcctagtaa ctatgtcact gaagcagaag actccataga aatgtatgag      840

tggtattcca aacacatgac tcggagtcag gctgagcaac tgctaaagca agaggggaaa      900

gaaggaggtt tcattgtcag agactccagc aaagctggca aatatacagt gtctgtgttt      960

gctaaatcca caggggaccc tcaaggggtg atacgtcatt atgttgtgtg ttccacacct     1020

cagagccagt attacctggc tgagaagcac cttttcagca ccatccctga gctcattaac     1080

taccatcagc acaactctgc aggactcata tccaggctca aatatccagt gtctcaacaa     1140

aacaagaatg caccttccac tgcaggcctg ggatacggat catgggaaat tgatccaaag     1200

gacctgacct tcttgaagga gctggggact ggacaatttg gggtagtgaa gtatgggaaa     1260

tggagaggcc agtacgacgt ggccatcaag atgatcaaag aaggctccat gtctgaagat     1320

gaattcattg aagaagccaa agtcatgatg aatctttccc atgagaagct ggtgcagttg     1380

tatggcgtct gcaccaagca gcgccccatc ttcatcatca ctgagtacat ggccaatggc     1440

tccctcctga actacctgag ggagatgcgc caccgcttcc agactcagca gctgctagag     1500

atgtgcaagg atgtctgtga agccatggaa tacctggagt caaagcagtt ccttcaccga     1560

gacctggcag ctcgaaactg tttggtaaac gatcaaggag ttgttaaagt atctgatttc     1620

ggcctgtcca ggtatgtcct ggatgatgaa tacacaagct cagtaggctc caaatttcca     1680

gtccggtggt ccccaccgga agtcctgatg tatagcaagt tcagcagcaa atctgacatt     1740

tgggcttttg gggttttgat gtgggaaatt tactccctgg ggaagatgcc atatgagaga     1800

tttactaaca gtgagactgc tgaacacatt gcccaaggcc tacgtctcta caggcctcat     1860

ctggcttcag agaaggtata taccatcatg tacagttgct ggcatgagaa agcagatgag     1920

cgtcccactt tcaaaattct tctgagcaat attctagatg tcatggatga agaatcc        1977


<210>  24
<211>  3462
<212>  DNA
<213>  Homo sapiens

<400>  24
atgccaggag gagggccaga gatggatgac tacatggaga cgctgaagga tgaagaggac       60

gccttgtggg agaatgtgga gtgtaaccgg cacatgctca gccgctatat caaccctgcc      120

aagctcacgc cctacctgcg tcagtgtaag gtcattgatg agcaggatga agatgaagtg      180

cttaatgccc ctatgctgcc atccaagatc aaccgagcag gccggctgtt ggacattcta      240

cataccaagg ggcaaagggg ctatgtggtc ttcttggaga gcctagaatt ttattaccca      300

gaactgtaca aactggtgac tgggaaagag cccactcgga gattctccac cattgtggtg      360

gaggaaggcc acgagggcct cacgcacttc ctgatgaacg aggtcatcaa gctgcagcag      420

cagatgaagg ccaaggacct gcaacgctgc gagctgctgg ccaggttgcg gcagctggag      480

gatgagaaga agcagatgac gctgacgcgc gtggagctgc taaccttcca ggagcggtac      540

tacaagatga aggaagagcg ggacagctac aatgacgagc tggtcaaggt gaaggacgac      600

aactacaact tagccatgcg ctacgcacag ctcagtgagg agaagaacat ggcggtcatg      660

aggagccgag acctccaact cgagatcgat cagctaaagc accggttgaa taagatggag      720

gaggaatgta agctggagag aaatcagtct ctaaaactga agaatgacat tgaaaatcgg      780

cccaagaagg agcaggttct ggaactggag cgggagaatg aaatgctgaa gaccaaaaac      840

caggagctgc agtccatcat ccaggccggg aagcgcagcc tgccagactc agacaaggcc      900

atcctggaca tcttggaaca cgaccgcaag gaggccctgg aggacaggca ggagctggtc      960

aacaggatct acaacctgca ggaggaggcc cgccaggcag aggagctgcg agacaagtac     1020

ctggaggaga aggaggacct ggagctcaag tgctcgaccc tgggaaagga ctgtgaaatg     1080

tacaagcacc gcatgaacac ggtcatgctg cagctggagg aggtggagcg ggagcgggac     1140

caggccttcc actcccgaga tgaagctcag acacagtact cgcagtgctt aatcgaaaag     1200

gacaagtaca ggaagcagat ccgcgagctg gaggagaaga acgacgagat gaggatcgag     1260

atggtgcggc gggaggcctg catcgtcaac ctggagagca agctgcggcg cctctccaag     1320

gacagcaaca acctggacca gagtctgccc aggaacctgc cagtaaccat catctctcag     1380

gactttgggg atgccagccc caggaccaat ggtcaagaag ctgacgattc ttccacctcg     1440

gaggagtcac ctgaagacag caagtacttc ctgccctacc atccgcccca gcgcaggatg     1500

aacctgaagg gcatccagct gcagagagcc aaatccccca tcagcctgaa gcgaacatca     1560

gattttcaag ccaaggggca cgaggaagaa ggcacggacg ccagccctag ctcctgcgga     1620

tctctgccca tcaccaactc cttcaccaag atgcagcccc cccggagccg cagcagcatc     1680

atgtcaatca ccgccgagcc cccgggaaac gactccatcg tcagacgcta caaggaggac     1740

gcgccccatc gcagcacagt cgaagaagac aatgacagcg gcgggtttga cgccttagat     1800

ctggatgatg acagtcacga acgctactcc ttcggaccct cctccatcca ctcctcctcc     1860

tcctcccacc aatccgaggg cctggatgcc tacgacctgg agcaggtcaa cctcatgttc     1920

aggaagttct ctctggaaag acccttccgg ccttcggtca cctctgtggg gcacgtgcgg     1980

ggcccagggc cctcggtgca gcacacgacg ctgaatggcg acagcctcac ctcccagctc     2040

accctgctgg ggggcaacgc gcgagggagc ttcgtgcact cggtcaagcc tggctctctg     2100

gccgagaaag ccggcctccg tgagggccac cagctgctgc tgctagaagg ctgcatccga     2160

ggcgagaggc agagtgtccc gttggacaca tgcaccaaag aggaagccca ctggaccatc     2220

cagaggtgca gcggccccgt cacgctgcac tacaaggtca accacgaagg gtaccggaag     2280

ctggtgaagg acatggagga cggcctgatc acatcggggg actcgttcta catccggctg     2340

aacctgaaca tctccagcca gctggacgcc tgcaccatgt ccctgaagtg tgacgatgtt     2400

gtgcacgtcc gtgacaccat gtaccaggac aggcacgagt ggctgtgcgc gcgggtcgac     2460

cctttcacag accatgacct ggatatgggc accataccca gctacagccg agcccagcag     2520

ctcctcctgg tgaaactgca gcgcctgatg caccgaggca gccgggagga ggtagacggc     2580

acccaccaca ccctgcgggc actccggaac accctgcagc cagaagaagc gctttcaaca     2640

agcgaccccc gggtcagccc ccgtctctcg cgagcaagct tcctttttgg ccagctcctt     2700

cagttcgtca gcaggtccga gaacaagtat aagcggatga acagcaacga gcgggtccgc     2760

atcatctcgg ggagtccgct agggagcctg gcccggtcct cgctggacgc caccaagctc     2820

ttgactgaga agcaggaaga gctggaccct gagagcgagc tgggcaagaa cctcagcctc     2880

atcccctaca gcctggtacg cgccttctac tgcgagcgcc gccggcccgt gctcttcaca     2940

cccaccgtgc tggccaagac gctggtgcag aggctgctca actcgggagg tgccatggag     3000

ttcaccatct gcaagtcaga tatcgtcaca agagatgagt tcctcagaag gcagaagacg     3060

gagaccatca tctactcccg agagaagaac cccaacgcgt tcgaatgcat cgcccctgcc     3120

aacattgaag ctgtggccgc caagaacaag cactgcctgc tggaggctgg gatcggctgc     3180

acaagagact tgatcaagtc caacatctac cccatcgtgc tcttcatccg ggtgtgtgag     3240

aagaacatca agaggttcag aaagctgctg ccccgacctg agacggagga ggagttcctg     3300

cgcgtgtgcc ggctgaagga gaaggagctg gaggccctgc cgtgcctgta cgccacggtg     3360

gaacctgaca tgtggggcag cgtagaggag ctgctccgcg ttgtcaagga caagatcggc     3420

gaggagcagc gcaagaccat ctgggtggac gaggaccagc tg                        3462


<210>  25
<211>  3465
<212>  DNA
<213>  Homo sapiens

<400>  25
atgccaggag gagggccaga gatggatgac tacatggaga cgctgaagga tgaagaggac       60

gccttgtggg agaatgtgga gtgtaaccgg cacatgctca gccgctatat caaccctgcc      120

aagctcacgc cctacctgcg tcagtgtaag gtcattgatg agcaggatga agatgaagtg      180

cttaatgccc ctatgctgcc atccaagatc aaccgagcag gccggctgtt ggacattcta      240

cataccaagg ggcaaagggg ctatgtggtc ttcttggaga gcctagaatt ttattaccca      300

gaactgtaca aactggtgac tgggaaagag cccactcgga gattctccac cattgtggtg      360

gaggaaggcc acgagggcct cacgcacttc ctgatgaacg aggtcatcaa gctgcagcag      420

cagatgaagg ccaaggacct gcaacgctgc gagctgctgg ccaggttgcg gcagctggag      480

gatgagaaga agcagatgac gctgacgcgc gtggagctgc taaccttcca ggagcggtac      540

tacaagatga aggaagagcg ggacagctac aatgacgagc tggtcaaggt gaaggacgac      600

aactacaact tagccatgcg ctacgcacag ctcagtgagg agaagaacat ggcggtcatg      660

aggagccgag acctccaact cgagatcgat cagcttttaa agcaccggtt gaataagatg      720

gaggaggaat gtaagctgga gagaaatcag tctctaaaac tgaagaatga cattgaaaat      780

cggcccaaga aggagcaggt tctggaactg gagcgggaga atgaaatgct gaagaccaaa      840

aaccaggagc tgcagtccat catccaggcc gggaagcgca gcctgccaga ctcagacaag      900

gccatcctgg acatcttgga acacgaccgc aaggaggccc tggaggacag gcaggagctg      960

gtcaacagga tctacaacct gcaggaggag gcccgccagg cagaggagct gcgagacaag     1020

tacctggagg agaaggagga cctggagctc aagtgctcga ccctgggaaa ggactgtgaa     1080

atgtacaagc accgcatgaa cacggtcatg ctgcagctgg aggaggtgga gcgggagcgg     1140

gaccaggcct tccactcccg agatgaagct cagacacagt actcgcagtg cttaatcgaa     1200

aaggacaagt acaggaagca gatccgcgag ctggaggaga agaacgacga gatgaggatc     1260

gagatggtgc ggcgggaggc ctgcatcgtc aacctggaga gcaagctgcg gcgcctctcc     1320

aaggacagca acaacctgga ccagagtctg cccaggaacc tgccagtaac catcatctct     1380

caggactttg gggatgccag ccccaggacc aatggtcaag aagctgacga ttcttccacc     1440

tcggaggagt cacctgaaga cagcaagtac ttcctgccct accatccgcc ccagcgcagg     1500

atgaacctga agggcatcca gctgcagaga gccaaatccc ccatcagcct gaagcgaaca     1560

tcagattttc aagccaaggg gcacgaggaa gaaggcacgg acgccagccc tagctcctgc     1620

ggatctctgc ccatcaccaa ctccttcacc aagatgcagc ccccccggag ccgcagcagc     1680

atcatgtcaa tcaccgccga gcccccggga aacgactcca tcgtcagacg ctacaaggag     1740

gacgcgcccc atcgcagcac agtcgaagaa gacaatgaca gcggcgggtt tgacgcctta     1800

gatctggatg atgacagtca cgaacgctac tccttcggac cctcctccat ccactcctcc     1860

tcctcctccc accaatccga gggcctggat gcctacgacc tggagcaggt caacctcatg     1920

ttcaggaagt tctctctgga aagacccttc cggccttcgg tcacctctgt ggggcacgtg     1980

cggggcccag ggccctcggt gcagcacacg acgctgaatg gcgacagcct cacctcccag     2040

ctcaccctgc tggggggcaa cgcgcgaggg agcttcgtgc actcggtcaa gcctggctct     2100

ctggccgaga aagccggcct ccgtgagggc caccagctgc tgctgctaga aggctgcatc     2160

cgaggcgaga ggcagagtgt cccgttggac acatgcacca aagaggaagc ccactggacc     2220

atccagaggt gcagcggccc cgtcacgctg cactacaagg tcaaccacga agggtaccgg     2280

aagctggtga aggacatgga ggacggcctg atcacatcgg gggactcgtt ctacatccgg     2340

ctgaacctga acatctccag ccagctggac gcctgcacca tgtccctgaa gtgtgacgat     2400

gttgtgcacg tccgtgacac catgtaccag gacaggcacg agtggctgtg cgcgcgggtc     2460

gaccctttca cagaccatga cctggatatg ggcaccatac ccagctacag ccgagcccag     2520

cagctcctcc tggtgaaact gcagcgcctg atgcaccgag gcagccggga ggaggtagac     2580

ggcacccacc acaccctgcg ggcactccgg aacaccctgc agccagaaga agcgctttca     2640

acaagcgacc cccgggtcag cccccgtctc tcgcgagcaa gcttcctttt tggccagctc     2700

cttcagttcg tcagcaggtc cgagaacaag tataagcgga tgaacagcaa cgagcgggtc     2760

cgcatcatct cggggagtcc gctagggagc ctggcccggt cctcgctgga cgccaccaag     2820

ctcttgactg agaagcagga agagctggac cctgagagcg agctgggcaa gaacctcagc     2880

ctcatcccct acagcctggt acgcgccttc tactgcgagc gccgccggcc cgtgctcttc     2940

acacccaccg tgctggccaa gacgctggtg cagaggctgc tcaactcggg aggtgccatg     3000

gagttcacca tctgcaagtc agatatcgtc acaagagatg agttcctcag aaggcagaag     3060

acggagacca tcatctactc ccgagagaag aaccccaacg cgttcgaatg catcgcccct     3120

gccaacattg aagctgtggc cgccaagaac aagcactgcc tgctggaggc tgggatcggc     3180

tgcacaagag acttgatcaa gtccaacatc taccccatcg tgctcttcat ccgggtgtgt     3240

gagaagaaca tcaagaggtt cagaaagctg ctgccccgac ctgagacgga ggaggagttc     3300

ctgcgcgtgt gccggctgaa ggagaaggag ctggaggccc tgccgtgcct gtacgccacg     3360

gtggaacctg acatgtgggg cagcgtagag gagctgctcc gcgttgtcaa ggacaagatc     3420

ggcgaggagc agcgcaagac catctgggtg gacgaggacc agctg                     3465


<210>  26
<211>  3795
<212>  DNA
<213>  Homo sapiens

<400>  26
atgtccacca cggtcaatgt agattccctt gcggaatatg agaagagcca gatcaagaga       60

gccctggagc tggggacggt gatgactgtg ttcagcttcc gcaagtccac ccccgagcgg      120

agaaccgtcc aggtgatcat ggagacgcgg caggtggcct ggagcaagac cgccgacaag      180

atcgagggct tcttggatat catggaaata aaagaaatcc gcccagggaa gaactccaaa      240

gatttcgagc gagcaaaagc agttcgccag aaagaagact gctgcttcac catcctatat      300

ggcactcagt tcgtcctcag cacgctcagc ttggcagctg actctaaaga ggatgcagtt      360

aactggctct ctggcttgaa aatcttacac caggaagcga tgaatgcgtc cacgcccacc      420

attatcgaga gttggctgag aaagcagata tattctgtgg atcaaaccag aagaaacagc      480

atcagtctcc gagagttgaa gaccatcttg cccctgatca actttaaagt gagcagtgcc      540

aagttcctta aagataagtt tgtggaaata ggagcacaca aagatgagct cagctttgaa      600

cagttccatc tcttctataa aaaacttatg tttgaacagc aaaaatcgat tctcgatgaa      660

ttcaaaaagg attcgtccgt gttcatcctg gggaacactg acaggccgga tgcctctgct      720

gtttacctgc atgacttcca gaggtttctc atacatgaac agcaggagca ttgggctcag      780

gatctgaaca aagtccgtga gcggatgaca aagttcattg atgacaccat gcgtgaaact      840

gctgagcctt tcttgtttgt ggatgagttc ctcacgtacc tgttttcacg agaaaacagc      900

atctgggatg agaagtatga cgcggtggac atgcaggaca tgaacaaccc cctgtctcat      960

tactggatct cctcgtcaca taacacgtac cttacaggtg accagctgcg gagcgagtcg     1020

tccccagaag cttacatccg ctgcctgcgc atgggctgtc gctgcattga actggactgc     1080

tgggacgggc ccgatgggaa gccggtcatc taccatggct ggacgcggac taccaagatc     1140

aagtttgacg acgtcgtgca ggccatcaaa gaccacgcct ttgttacctc gagcttccca     1200

gtgatcctgt ccatcgagga gcactgcagc gtggagcaac agcgtcacat ggccaaggcc     1260

ttcaaggaag tatttggcga cctgctgttg acgaagccca cggaggccag tgctgaccag     1320

ctgccctcgc ccagccagct gcgggagaag atcatcatca agcataagaa gctgggcccc     1380

cgaggcgatg tggatgtcaa catggaggac aagaaggacg aacacaagca acagggggag     1440

ctgtacatgt gggattccat tgaccagaaa tggactcggc actactgcgc cattgccgat     1500

gccaagctgt ccttcagtga tgacattgaa cagactatgg aggaggaagt gccccaggat     1560

atacccccta cagaactaca ttttggggag aaatggttcc acaagaaggt ggagaagagg     1620

acgagtgccg agaagttgct gcaggaatac tgcatggaga cggggggcaa ggatggcacc     1680

ttcctggttc gggagagcga gaccttcccc aatgactaca ccctgtcctt ctggcggtca     1740

ggccgggtcc agcactgccg gatccgctcc accatggagg gcgggaccct gaaatactac     1800

ttgactgaca acctcacctt cagcagcatc tatgccctca tccagcacta ccgcgagacg     1860

cacctgcgct gcgccgagtt cgagctgcgg ctcacggacc ctgtgcccaa ccccaacccc     1920

cacgagtcca agccgtggta ctatgacagc ctgagccgcg gagaggcaga ggacatgctg     1980

atgaggattc cccgggacgg ggccttcctg atccggaagc gagaggggag cgactcctat     2040

gccatcacct tcagggctag gggcaaggta aagcattgtc gcatcaaccg ggacggccgg     2100

cactttgtgc tggggacctc cgcctatttt gagagtctgg tggagctcgt cagttactac     2160

gagaagcatt cactctaccg aaagatgaga ctgcgctacc ccgtgacccc cgagctcctg     2220

gagcgctaca atatggaaag agatataaac tccctctacg acgtcagcag aatgtatgtg     2280

gatcccagtg aaatcaatcc gtccatgcct cagagaaccg tgaaagctct gtatgactac     2340

aaagccaagc gaagcgatga gctgagcttc tgccgtggtg ccctcatcca caatgtctcc     2400

aaggagcccg ggggctggtg gaaaggagac tatggaacca ggatccagca gtacttccca     2460

tccaactacg tcgaggacat ctcaactgca gacttcgagg agctagaaaa gcagattatt     2520

gaagacaatc ccttagggtc tctttgcaga ggaatattgg acctcaatac ctataacgtc     2580

gtgaaagccc ctcagggaaa aaaccagaag tcctttgtct tcatcctgga gcccaagcag     2640

cagggcgatc ctccggtgga gtttgccaca gacagggtgg aggagctctt tgagtggttt     2700

cagagcatcc gagagatcac ctggaagatt gacaccaagg agaacaacat gaagtactgg     2760

gagaagaacc agtccatcgc catcgagctc tctgacctgg ttgtctactg caaaccaacc     2820

agcaaaacca aggacaactt agaaaatcct gacttccgag aaatccgctc ctttgtggag     2880

acgaaggctg acagcatcat cagacagaag cccgtcgacc tcctgaagta caatcaaaag     2940

ggcctgaccc gcgtctaccc aaagggacaa agagttgact cttcaaacta cgaccccttc     3000

cgcctctggc tgtgcggttc tcagatggtg gcactcaatt tccagacggc agataagtac     3060

atgcagatga atcacgcatt gttttctctc aatgggcgca cgggctacgt tctgcagcct     3120

gagagcatga ggacagagaa atatgacccg atgccacccg agtcccagag gaagatcctg     3180

atgacgctga cagtcaaggt tctcggtgct cgccatctcc ccaaacttgg acgaagtatt     3240

gcctgtccct ttgtagaagt ggagatctgt ggagccgagt atgacaacaa caagttcaag     3300

acgacggttg tgaatgataa tggcctcagc cctatctggg ctccaacaca ggagaaggtg     3360

acatttgaaa tttatgaccc aaacctggca tttctgcgct ttgtggttta tgaagaagat     3420

atgttcagcg atcccaactt tcttgctcat gccacttacc ccattaaagc agtcaaatca     3480

ggattcaggt ccgttcctct gaagaatggg tacagcgagg acatagagct ggcttccctc     3540

ctggttttct gtgagatgcg gccagtcctg gagagcgaag aggaacttta ctcctcctgt     3600

cgccagctga ggaggcggca agaagaactg aacaaccagc tctttctgta tgacacacac     3660

cagaacttgc gcaatgccaa ccgggatgcc ctggttaaag agttcagtgt taatgagaac     3720

cagctccagc tgtaccagga gaaatgcaac aagaggttaa gagagaagag agtcagcaac     3780

agcaagtttt actca                                                      3795


<210>  27
<211>  3795
<212>  DNA
<213>  Homo sapiens

<400>  27
atgtccacca cggtcaatgt agattccctt gcggaatatg agaagagcca gatcaagaga       60

gccctggagc tggggacggt gatgactgtg ttcagcttcc gcaagtccac ccccgagcgg      120

agaaccgtcc aggtgatcat ggagacgcgg caggtggcct ggagcaagac cgccgacaag      180

atcgagggct tcttggatat catggaaata aaagaaatcc gcccagggaa gaactccaaa      240

gatttcgagc gagcaaaagc agttcgccag aaagaagact gctgcttcac catcctatat      300

ggcactcagt tcgtcctcag cacgctcagc ttggcagctg actctaaaga ggatgcagtt      360

aactggctct ctggcttgaa aatcttacac caggaagcga tgaatgcgtc cacgcccacc      420

attatcgaga gttggctgag aaagcagata tattctgtgg atcaaaccag aagaaacagc      480

atcagtctcc gagagttgaa gaccatcttg cccctgatca actttaaagt gagcagtgcc      540

aagttcctta aagataagtt tgtggaaata ggagcacaca aagatgagct cagctttgaa      600

cagttccatc tcttctataa aaaacttatg tttgaacagc aaaaatcgat tctcgatgaa      660

ttcaaaaagg attcgtccgt gttcatcctg gggaacactg acaggccgga tgcctctgct      720

gtttacctgc atgacttcca gaggtttctc atacatgaac agcaggagca ttgggctcag      780

gatctgaaca aagtccgtga gcggatgaca aagttcattg atgacaccat gcgtgaaact      840

gctgagcctt tcttgtttgt ggatgagttc ctcacgtacc tgttttcacg agaaaacagc      900

atctgggatg agaagtatga cgcggtggac atgcaggaca tgaacaaccc cctgtctcat      960

tactggatct cctcgtcaca taacacgtac cttacaggtg accagctgcg gagcgagtcg     1020

tccccagaag cttacatccg ctgcctgcgc atgggctgtc gctgcattga actggactgc     1080

tgggacgggc ccgatgggaa gccggtcatc taccatggct ggacgcggac taccaagatc     1140

aagtttgacg acgtcgtgca ggccatcaaa gaccacgcct ttgttacctc gagcttccca     1200

gtgatcctgt ccatcgagga gcactgcagc gtggagcaac agcgtcacat ggccaaggcc     1260

ttcaaggaag tatttggcga cctgctgttg acgaagccca cggaggccag tgctgaccag     1320

ctgccctcgc ccagccagct gcgggagaag atcatcatca agcataagaa gctgggcccc     1380

cgaggcgatg tggatgtcaa catggaggac aagaaggacg aacacaagca acagggggag     1440

ctgtacatgt gggattccat tgaccagaaa tggactcggc actactgcgc cattgccgat     1500

gccaagctgt ccttcagtga tgacattgaa cagactatgg aggaggaagt gccccaggat     1560

atacccccta cagaactaca ttttggggag aaatggttcc acaagaaggt ggagaagagg     1620

acgagtgccg agaagttgct gcaggaatac tgcatggaga cggggggcaa ggatggcacc     1680

ttcctggttc gggagagcga gaccttcccc aatgactaca ccctgtcctt ctggcggtca     1740

ggccgggtcc agcactgccg gatccgctcc accatggagg gcgggaccct gaaatactac     1800

ttgactgaca acctcacctt cagcagcatc tatgccctca tccagcacta ccgcgagacg     1860

cacctgcgct gcgccgagtt cgagctgcgg ctcacggacc ctgtgcccaa ccccaacccc     1920

cacgagtcca agccgtggta ctatgacagc ctgagccgcg gagaggcaga ggacatgctg     1980

atgaggattc cctgggacgg ggccttcctg atccggaagc gagaggggag cgactcctat     2040

gccatcacct tcagggctag gggcaaggta aagcattgtc gcatcaaccg ggacggccgg     2100

cactttgtgc tggggacctc cgcctatttt gagagtctgg tggagctcgt cagttactac     2160

gagaagcatt cactctaccg aaagatgaga ctgcgctacc ccgtgacccc cgagctcctg     2220

gagcgctaca atatggaaag agatataaac tccctctacg acgtcagcag aatgtatgtg     2280

gatcccagtg aaatcaatcc gtccatgcct cagagaaccg tgaaagctct gtatgactac     2340

aaagccaagc gaagcgatga gctgagcttc tgccgtggtg ccctcatcca caatgtctcc     2400

aaggagcccg ggggctggtg gaaaggagac tatggaacca ggatccagca gtacttccca     2460

tccaactacg tcgaggacat ctcaactgca gacttcgagg agctagaaaa gcagattatt     2520

gaagacaatc ccttagggtc tctttgcaga ggaatattgg acctcaatac ctataacgtc     2580

gtgaaagccc ctcagggaaa aaaccagaag tcctttgtct tcatcctgga gcccaagcag     2640

cagggcgatc ctccggtgga gtttgccaca gacagggtgg aggagctctt tgagtggttt     2700

cagagcatcc gagagatcac ctggaagatt gacaccaagg agaacaacat gaagtactgg     2760

gagaagaacc agtccatcgc catcgagctc tctgacctgg ttgtctactg caaaccaacc     2820

agcaaaacca aggacaactt agaaaatcct gacttccgag aaatccgctc ctttgtggag     2880

acgaaggctg acagcatcat cagacagaag cccgtcgacc tcctgaagta caatcaaaag     2940

ggcctgaccc gcgtctaccc aaagggacaa agagttgact cttcaaacta cgaccccttc     3000

cgcctctggc tgtgcggttc tcagatggtg gcactcaatt tccagacggc agataagtac     3060

atgcagatga atcacgcatt gttttctctc aatgggcgca cgggctacgt tctgcagcct     3120

gagagcatga ggacagagaa atatgacccg atgccacccg agtcccagag gaagatcctg     3180

atgacgctga cagtcaaggt tctcggtgct cgccatctcc ccaaacttgg acgaagtatt     3240

gcctgtccct ttgtagaagt ggagatctgt ggagccgagt atgacaacaa caagttcaag     3300

acgacggttg tgaatgataa tggcctcagc cctatctggg ctccaacaca ggagaaggtg     3360

acatttgaaa tttatgaccc aaacctggca tttctgcgct ttgtggttta tgaagaagat     3420

atgttcagcg atcccaactt tcttgctcat gccacttacc ccattaaagc agtcaaatca     3480

ggattcaggt ccgttcctct gaagaatggg tacagcgagg acatagagct ggcttccctc     3540

ctggttttct gtgagatgcg gccagtcctg gagagcgaag aggaacttta ctcctcctgt     3600

cgccagctga ggaggcggca agaagaactg aacaaccagc tctttctgta tgacacacac     3660

cagaacttgc gcaatgccaa ccgggatgcc ctggttaaag agttcagtgt taatgagaac     3720

cagctccagc tgtaccagga gaaatgcaac aagaggttaa gagagaagag agtcagcaac     3780

agcaagtttt actca                                                      3795


<210>  28
<211>  3795
<212>  DNA
<213>  Homo sapiens

<400>  28
atgtccacca cggtcaatgt agattccctt gcggaatatg agaagagcca gatcaagaga       60

gccctggagc tggggacggt gatgactgtg ttcagcttcc gcaagtccac ccccgagcgg      120

agaaccgtcc aggtgatcat ggagacgcgg caggtggcct ggagcaagac cgccgacaag      180

atcgagggct tcttggatat catggaaata aaagaaatcc gcccagggaa gaactccaaa      240

gatttcgagc gagcaaaagc agttcgccag aaagaagact gctgcttcac catcctatat      300

ggcactcagt tcgtcctcag cacgctcagc ttggcagctg actctaaaga ggatgcagtt      360

aactggctct ctggcttgaa aatcttacac caggaagcga tgaatgcgtc cacgcccacc      420

attatcgaga gttggctgag aaagcagata tattctgtgg atcaaaccag aagaaacagc      480

atcagtctcc gagagttgaa gaccatcttg cccctgatca actttaaagt gagcagtgcc      540

aagttcctta aagataagtt tgtggaaata ggagcacaca aagatgagct cagctttgaa      600

cagttccatc tcttctataa aaaacttatg tttgaacagc aaaaatcgat tctcgatgaa      660

ttcaaaaagg attcgtccgt gttcatcctg gggaacactg acaggccgga tgcctctgct      720

gtttacctgc atgacttcca gaggtttctc atacatgaac agcaggagca ttgggctcag      780

gatctgaaca aagtccgtga gcggatgaca aagttcattg atgacaccat gcgtgaaact      840

gctgagcctt tcttgtttgt ggatgagttc ctcacgtacc tgttttcacg agaaaacagc      900

atctgggatg agaagtatga cgcggtggac atgcaggaca tgaacaaccc cctgtctcat      960

tactggatct cctcgtcaca taacacgtac cttacaggtg accagctgcg gagcgagtcg     1020

tccccagaag cttacatccg ctgcctgcgc atgggctgtc gctgcattga actggactgc     1080

tgggacgggc ccgatgggaa gccggtcatc taccatggct ggacgcggac taccaagatc     1140

aagtttgacg acgtcgtgca ggccatcaaa gaccacgcct ttgttacctc gagcttccca     1200

gtgatcctgt ccatcgagga gcactgcagc gtggagcaac agcgtcacat ggccaaggcc     1260

ttcaaggaag tatttggcga cctgctgttg acgaagccca cggaggccag tgctgaccag     1320

ctgccctcgc ccagccagct gcgggagaag atcatcatca agcataagaa gctgggcccc     1380

cgaggcgatg tggatgtcaa catggaggac aagaaggacg aacacaagca acagggggag     1440

ctgtacatgt gggattccat tgaccagaaa tggactcggc actactgcgc cattgccgat     1500

gccaagctgt ccttcagtga tgacattgaa cagactatgg aggaggaagt gccccaggat     1560

atacccccta cagaactaca ttttggggag aaatggttcc acaagaaggt ggagaagagg     1620

acgagtgccg agaagttgct gcaggaatac tgcatggaga cggggggcaa ggatggcacc     1680

ttcctggttc gggagagcga gaccttcccc aatgactaca ccctgtcctt ctggcggtca     1740

ggccgggtcc agcactgccg gatccgctcc accatggagg gcgggaccct gaaatactac     1800

ttgactgaca acctcacctt cagcagcatc tatgccctca tccagcacta ccgcgagacg     1860

cacctgcgct gcgccgagtt cgagctgcgg ctcacggacc ctgtgcccaa ccccaacccc     1920

cacgagtcca agccgtggta ctatgacagc ctgagccgcg gagaggcaga ggacatgctg     1980

atgaggattc cccgggacgg ggccttcctg atccggaagc gagaggggag cgactcctat     2040

gccatcacct tcagggctag gggcaaggta aagcattgtc gcatcaaccg ggacggccgg     2100

cactttgtgc tggggacctt cgcctatttt gagagtctgg tggagctcgt cagttactac     2160

gagaagcatt cactctaccg aaagatgaga ctgcgctacc ccgtgacccc cgagctcctg     2220

gagcgctaca atatggaaag agatataaac tccctctacg acgtcagcag aatgtatgtg     2280

gatcccagtg aaatcaatcc gtccatgcct cagagaaccg tgaaagctct gtatgactac     2340

aaagccaagc gaagcgatga gctgagcttc tgccgtggtg ccctcatcca caatgtctcc     2400

aaggagcccg ggggctggtg gaaaggagac tatggaacca ggatccagca gtacttccca     2460

tccaactacg tcgaggacat ctcaactgca gacttcgagg agctagaaaa gcagattatt     2520

gaagacaatc ccttagggtc tctttgcaga ggaatattgg acctcaatac ctataacgtc     2580

gtgaaagccc ctcagggaaa aaaccagaag tcctttgtct tcatcctgga gcccaagcag     2640

cagggcgatc ctccggtgga gtttgccaca gacagggtgg aggagctctt tgagtggttt     2700

cagagcatcc gagagatcac ctggaagatt gacaccaagg agaacaacat gaagtactgg     2760

gagaagaacc agtccatcgc catcgagctc tctgacctgg ttgtctactg caaaccaacc     2820

agcaaaacca aggacaactt agaaaatcct gacttccgag aaatccgctc ctttgtggag     2880

acgaaggctg acagcatcat cagacagaag cccgtcgacc tcctgaagta caatcaaaag     2940

ggcctgaccc gcgtctaccc aaagggacaa agagttgact cttcaaacta cgaccccttc     3000

cgcctctggc tgtgcggttc tcagatggtg gcactcaatt tccagacggc agataagtac     3060

atgcagatga atcacgcatt gttttctctc aatgggcgca cgggctacgt tctgcagcct     3120

gagagcatga ggacagagaa atatgacccg atgccacccg agtcccagag gaagatcctg     3180

atgacgctga cagtcaaggt tctcggtgct cgccatctcc ccaaacttgg acgaagtatt     3240

gcctgtccct ttgtagaagt ggagatctgt ggagccgagt atgacaacaa caagttcaag     3300

acgacggttg tgaatgataa tggcctcagc cctatctggg ctccaacaca ggagaaggtg     3360

acatttgaaa tttatgaccc aaacctggca tttctgcgct ttgtggttta tgaagaagat     3420

atgttcagcg atcccaactt tcttgctcat gccacttacc ccattaaagc agtcaaatca     3480

ggattcaggt ccgttcctct gaagaatggg tacagcgagg acatagagct ggcttccctc     3540

ctggttttct gtgagatgcg gccagtcctg gagagcgaag aggaacttta ctcctcctgt     3600

cgccagctga ggaggcggca agaagaactg aacaaccagc tctttctgta tgacacacac     3660

cagaacttgc gcaatgccaa ccgggatgcc ctggttaaag agttcagtgt taatgagaac     3720

cagctccagc tgtaccagga gaaatgcaac aagaggttaa gagagaagag agtcagcaac     3780

agcaagtttt actca                                                      3795


