                         SEQUENCE LISTING

<110>  La Jolla Institute of Allergy and Immunology
       Bottini, Nanzio
       Stanford, Stephanie
 
<120>  PTPRS AND PROTEOGLYCANS IN RHEUMATOID ARTHRITIS

<130>  93138-000400PC-880314

<150>  61/674,853
<151>  2012-07-23

<150>  61/675,036
<151>  2012-07-24

<150>  61/832,688
<151>  2013-06-07

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  97
<212>  PRT
<213>  Mus musculus

<400>  1

Glu Glu Pro Arg Phe Ile Lys Glu Pro Lys Asp Gln Ile Gly Val Ser 
1               5                   10                  15      


Gly Gly Val Ala Ser Phe Val Cys Gln Ala Thr Gly Asp Pro Lys Pro 
            20                  25                  30          


Arg Val Thr Trp Asn Lys Lys Gly Lys Lys Val Asn Ser Gln Arg Phe 
        35                  40                  45              


Glu Thr Ile Glu Phe Asp Glu Ser Ala Gly Ala Val Leu Arg Ile Gln 
    50                  55                  60                  


Pro Leu Arg Thr Pro Arg Asp Glu Asn Val Tyr Glu Cys Val Ala Gln 
65                  70                  75                  80  


Asn Ser Val Gly Glu Ile Thr Val His Ala Lys Leu Thr Val Leu Arg 
                85                  90                  95      


Glu 
    


<210>  2
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  2

Asp Gln Leu Pro Ser Gly Phe Pro Asn Ile Asp Met Gly Pro Gln Leu 
1               5                   10                  15      


Lys Val Val Glu Arg Thr Arg Thr Ala Thr Met Leu Cys Ala Ala Ser 
            20                  25                  30          


Gly Asn Pro Asp Pro Glu Ile Thr Trp Phe Lys Asp Phe Leu Pro Val 
        35                  40                  45              


Asp Pro Ser Ala Ser Asn Gly Arg Ile Lys Gln Leu Arg Ser Glu Thr 
    50                  55                  60                  


Phe Glu Ser Thr Pro Ile Arg Gly Ala Leu Gln Ile Glu Ser Ser Glu 
65                  70                  75                  80  


Glu Thr Asp Gln Gly Lys Tyr Glu Cys Val Ala Thr Asn Ser Ala Gly 
                85                  90                  95      


Val Arg Tyr Ser Ser Pro Ala Asn Leu Tyr Val Arg Val Arg Arg Val 
            100                 105                 110         


Ala 
    


<210>  3
<211>  90
<212>  PRT
<213>  Mus musculus

<400>  3

Pro Arg Phe Ser Ile Leu Pro Met Ser His Glu Ile Met Pro Gly Gly 
1               5                   10                  15      


Asn Val Asn Ile Thr Cys Val Ala Val Gly Ser Pro Met Pro Tyr Val 
            20                  25                  30          


Lys Trp Met Gln Gly Ala Glu Asp Leu Thr Pro Glu Asp Asp Met Pro 
        35                  40                  45              


Val Gly Arg Asn Val Leu Glu Leu Thr Asp Val Lys Asp Ser Ala Asn 
    50                  55                  60                  


Tyr Thr Cys Val Ala Met Ser Ser Leu Gly Val Ile Glu Ala Val Ala 
65                  70                  75                  80  


Gln Ile Thr Val Lys Ser Leu Pro Lys Ala 
                85                  90  


<210>  4
<211>  1907
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ala Pro Thr Trp Ser Pro Ser Val Val Ser Val Val Gly Pro Val 
1               5                   10                  15      


Gly Leu Phe Leu Val Leu Leu Ala Arg Gly Cys Leu Ala Glu Glu Pro 
            20                  25                  30          


Pro Arg Phe Ile Arg Glu Pro Lys Asp Gln Ile Gly Val Ser Gly Gly 
        35                  40                  45              


Val Ala Ser Phe Val Cys Gln Ala Thr Gly Asp Pro Lys Pro Arg Val 
    50                  55                  60                  


Thr Trp Asn Lys Lys Gly Lys Lys Val Asn Ser Gln Arg Phe Glu Thr 
65                  70                  75                  80  


Ile Asp Phe Asp Glu Ser Ser Gly Ala Val Leu Arg Ile Gln Pro Leu 
                85                  90                  95      


Arg Thr Pro Arg Asp Glu Asn Val Tyr Glu Cys Val Ala Gln Asn Ser 
            100                 105                 110         


Val Gly Glu Ile Thr Ile His Ala Lys Leu Thr Val Leu Arg Glu Asp 
        115                 120                 125             


Gln Leu Pro Pro Gly Phe Pro Asn Ile Asp Met Gly Pro Gln Leu Lys 
    130                 135                 140                 


Val Val Glu Arg Thr Arg Thr Ala Thr Met Leu Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Asn Pro Asp Pro Glu Ile Thr Trp Phe Lys Asp Phe Leu Pro Val Asp 
                165                 170                 175     


Pro Ser Ala Ser Asn Gly Arg Ile Lys Gln Leu Arg Ser Gly Ala Leu 
            180                 185                 190         


Gln Ile Glu Ser Ser Glu Glu Thr Asp Gln Gly Lys Tyr Glu Cys Val 
        195                 200                 205             


Ala Thr Asn Ser Ala Gly Val Arg Tyr Ser Ser Pro Ala Asn Leu Tyr 
    210                 215                 220                 


Val Arg Val Arg Arg Val Ala Pro Arg Phe Ser Ile Leu Pro Met Ser 
225                 230                 235                 240 


His Glu Ile Met Pro Gly Gly Asn Val Asn Ile Thr Cys Val Ala Val 
                245                 250                 255     


Gly Ser Pro Met Pro Tyr Val Lys Trp Met Gln Gly Ala Glu Asp Leu 
            260                 265                 270         


Thr Pro Glu Asp Asp Met Pro Val Gly Arg Asn Val Leu Glu Leu Thr 
        275                 280                 285             


Asp Val Lys Asp Ser Ala Asn Tyr Thr Cys Val Ala Met Ser Ser Leu 
    290                 295                 300                 


Gly Val Ile Glu Ala Val Ala Gln Ile Thr Val Lys Ser Leu Pro Lys 
305                 310                 315                 320 


Ala Pro Gly Thr Pro Val Val Thr Glu Asn Thr Ala Thr Ser Ile Thr 
                325                 330                 335     


Val Thr Trp Asp Ser Gly Asn Pro Asp Pro Val Ser Tyr Tyr Val Ile 
            340                 345                 350         


Glu Tyr Lys Ser Lys Ser Gln Asp Gly Pro Tyr Gln Ile Lys Glu Asp 
        355                 360                 365             


Ile Thr Thr Thr Arg Tyr Ser Ile Gly Gly Leu Ser Pro Asn Ser Glu 
    370                 375                 380                 


Tyr Glu Ile Trp Val Ser Ala Val Asn Ser Ile Gly Gln Gly Pro Pro 
385                 390                 395                 400 


Ser Glu Ser Val Val Thr Arg Thr Gly Glu Gln Ala Pro Ala Ser Ala 
                405                 410                 415     


Pro Arg Asn Val Gln Ala Arg Met Leu Ser Ala Thr Thr Met Ile Val 
            420                 425                 430         


Gln Trp Glu Glu Pro Val Glu Pro Asn Gly Leu Ile Arg Gly Tyr Arg 
        435                 440                 445             


Val Tyr Tyr Thr Met Glu Pro Glu His Pro Val Gly Asn Trp Gln Lys 
    450                 455                 460                 


His Asn Val Asp Asp Ser Leu Leu Thr Thr Val Gly Ser Leu Leu Glu 
465                 470                 475                 480 


Asp Glu Thr Tyr Thr Val Arg Val Leu Ala Phe Thr Ser Val Gly Asp 
                485                 490                 495     


Gly Pro Leu Ser Asp Pro Ile Gln Val Lys Thr Gln Gln Gly Val Pro 
            500                 505                 510         


Gly Gln Pro Met Asn Leu Arg Ala Glu Ala Lys Ser Glu Thr Ser Ile 
        515                 520                 525             


Gly Leu Ser Trp Ser Ala Pro Arg Gln Glu Ser Val Ile Lys Tyr Glu 
    530                 535                 540                 


Leu Leu Phe Arg Glu Gly Asp Arg Gly Arg Glu Val Gly Arg Thr Phe 
545                 550                 555                 560 


Asp Pro Thr Thr Ala Phe Val Val Glu Asp Leu Lys Pro Asn Thr Glu 
                565                 570                 575     


Tyr Ala Phe Arg Leu Ala Ala Arg Ser Pro Gln Gly Leu Gly Ala Phe 
            580                 585                 590         


Thr Ala Val Val Arg Gln Arg Thr Leu Gln Ala Lys Pro Ser Ala Pro 
        595                 600                 605             


Pro Gln Asp Val Lys Cys Thr Ser Leu Arg Ser Thr Ala Ile Leu Val 
    610                 615                 620                 


Ser Trp Arg Pro Pro Pro Pro Glu Thr His Asn Gly Ala Leu Val Gly 
625                 630                 635                 640 


Tyr Ser Val Arg Tyr Arg Pro Leu Gly Ser Glu Asp Pro Asp Pro Lys 
                645                 650                 655     


Glu Val Asn Asn Ile Pro Pro Thr Thr Thr Gln Ile Leu Leu Glu Ala 
            660                 665                 670         


Leu Glu Lys Trp Thr Glu Tyr Arg Val Thr Ala Val Ala Tyr Thr Glu 
        675                 680                 685             


Val Gly Pro Gly Pro Glu Ser Ser Pro Val Val Val Arg Thr Asp Glu 
    690                 695                 700                 


Asp Val Pro Ser Ala Pro Pro Arg Lys Val Glu Ala Glu Ala Leu Asn 
705                 710                 715                 720 


Ala Thr Ala Ile Arg Val Leu Trp Arg Ser Pro Thr Pro Gly Arg Gln 
                725                 730                 735     


His Gly Gln Ile Arg Gly Tyr Gln Val His Tyr Val Arg Met Glu Gly 
            740                 745                 750         


Ala Glu Ala Arg Gly Pro Pro Arg Ile Lys Asp Ile Met Leu Ala Asp 
        755                 760                 765             


Ala Gln Glu Met Val Ile Thr Asn Leu Gln Pro Glu Thr Ala Tyr Ser 
    770                 775                 780                 


Ile Thr Val Ala Ala Tyr Thr Met Lys Gly Asp Gly Ala Arg Ser Lys 
785                 790                 795                 800 


Pro Lys Val Val Val Thr Lys Gly Ala Val Leu Gly Arg Pro Thr Leu 
                805                 810                 815     


Ser Val Gln Gln Thr Pro Glu Gly Ser Leu Leu Ala Arg Trp Glu Pro 
            820                 825                 830         


Pro Ala Asp Ala Ala Glu Asp Pro Val Leu Gly Tyr Arg Leu Gln Phe 
        835                 840                 845             


Gly Arg Glu Asp Ala Ala Pro Ala Thr Leu Glu Leu Ala Ala Trp Glu 
    850                 855                 860                 


Arg Arg Phe Ala Ala Pro Ala His Lys Gly Ala Thr Tyr Val Phe Arg 
865                 870                 875                 880 


Leu Ala Ala Arg Gly Arg Ala Gly Leu Gly Glu Glu Ala Ala Ala Ala 
                885                 890                 895     


Leu Ser Ile Pro Glu Asp Ala Pro Arg Gly Phe Pro Gln Ile Leu Gly 
            900                 905                 910         


Ala Ala Gly Asn Val Ser Ala Gly Ser Val Leu Leu Arg Trp Leu Pro 
        915                 920                 925             


Pro Val Pro Ala Glu Arg Asn Gly Ala Ile Ile Lys Tyr Thr Val Ser 
    930                 935                 940                 


Val Arg Glu Ala Gly Ala Pro Gly Pro Ala Thr Glu Thr Glu Leu Ala 
945                 950                 955                 960 


Ala Ala Ala Gln Pro Gly Ala Glu Thr Ala Leu Thr Leu Arg Gly Leu 
                965                 970                 975     


Arg Pro Glu Thr Ala Tyr Glu Leu Arg Val Arg Ala His Thr Arg Arg 
            980                 985                 990         


Gly Pro Gly Pro Phe Ser Pro Pro  Leu Arg Tyr Arg Leu  Ala Arg Asp 
        995                 1000                 1005             


Pro Val  Ser Pro Lys Asn Phe  Lys Val Lys Met Ile  Met Lys Thr 
    1010                 1015                 1020             


Ser Val  Leu Leu Ser Trp Glu  Phe Pro Asp Asn Tyr  Asn Ser Pro 
    1025                 1030                 1035             


Thr Pro  Tyr Lys Ile Gln Tyr  Asn Gly Leu Thr Leu  Asp Val Asp 
    1040                 1045                 1050             


Gly Arg  Thr Thr Lys Lys Leu  Ile Thr His Leu Lys  Pro His Thr 
    1055                 1060                 1065             


Phe Tyr  Asn Phe Val Leu Thr  Asn Arg Gly Ser Ser  Leu Gly Gly 
    1070                 1075                 1080             


Leu Gln  Gln Thr Val Thr Ala  Arg Thr Ala Phe Asn  Met Leu Ser 
    1085                 1090                 1095             


Gly Lys  Pro Ser Val Ala Pro  Lys Pro Asp Asn Asp  Gly Phe Ile 
    1100                 1105                 1110             


Val Val  Tyr Leu Pro Asp Gly  Gln Ser Pro Val Thr  Val Gln Asn 
    1115                 1120                 1125             


Tyr Phe  Ile Val Met Val Pro  Leu Arg Lys Ser Arg  Gly Gly Gln 
    1130                 1135                 1140             


Phe Pro  Val Leu Leu Gly Ser  Pro Glu Asp Met Asp  Leu Glu Glu 
    1145                 1150                 1155             


Leu Ile  Gln Asp Ile Ser Arg  Leu Gln Arg Arg Ser  Leu Arg His 
    1160                 1165                 1170             


Ser Arg  Gln Leu Glu Val Pro  Arg Pro Tyr Ile Ala  Ala Arg Phe 
    1175                 1180                 1185             


Ser Ile  Leu Pro Ala Val Phe  His Pro Gly Asn Gln  Lys Gln Tyr 
    1190                 1195                 1200             


Gly Gly  Phe Asp Asn Arg Gly  Leu Glu Pro Gly His  Arg Tyr Val 
    1205                 1210                 1215             


Leu Phe  Val Leu Ala Val Leu  Gln Lys Asn Glu Pro  Thr Phe Ala 
    1220                 1225                 1230             


Ala Ser  Pro Phe Ser Asp Pro  Phe Gln Leu Asp Asn  Pro Asp Pro 
    1235                 1240                 1245             


Gln Pro  Ile Val Asp Gly Glu  Glu Gly Leu Ile Trp  Val Ile Gly 
    1250                 1255                 1260             


Pro Val  Leu Ala Val Val Phe  Ile Ile Cys Ile Val  Ile Ala Ile 
    1265                 1270                 1275             


Leu Leu  Tyr Lys Asn Lys Pro  Asp Ser Lys Arg Lys  Asp Ser Glu 
    1280                 1285                 1290             


Pro Arg  Thr Lys Cys Leu Leu  Asn Asn Ala Asp Leu  Ala Pro His 
    1295                 1300                 1305             


His Pro  Lys Asp Pro Val Glu  Met Arg Arg Ile Asn  Phe Gln Thr 
    1310                 1315                 1320             


Pro Gly  Met Leu Ser His Pro  Pro Ile Pro Ile Thr  Asp Met Ala 
    1325                 1330                 1335             


Glu His  Met Glu Arg Leu Lys  Ala Asn Asp Ser Leu  Lys Leu Ser 
    1340                 1345                 1350             


Gln Glu  Tyr Glu Ser Ile Asp  Pro Gly Gln Gln Phe  Thr Trp Glu 
    1355                 1360                 1365             


His Ser  Asn Leu Glu Ala Asn  Lys Pro Lys Asn Arg  Tyr Ala Asn 
    1370                 1375                 1380             


Val Ile  Ala Tyr Asp His Ser  Arg Val Ile Leu Gln  Pro Leu Glu 
    1385                 1390                 1395             


Gly Ile  Met Gly Ser Asp Tyr  Ile Asn Ala Asn Tyr  Val Asp Gly 
    1400                 1405                 1410             


Tyr Arg  Arg Gln Asn Ala Tyr  Ile Ala Thr Gln Gly  Pro Leu Pro 
    1415                 1420                 1425             


Glu Thr  Phe Gly Asp Phe Trp  Arg Met Val Trp Glu  Gln Arg Ser 
    1430                 1435                 1440             


Ala Thr  Val Val Met Met Thr  Arg Leu Glu Glu Lys  Ser Arg Ile 
    1445                 1450                 1455             


Lys Cys  Asp Gln Tyr Trp Pro  Asn Arg Gly Thr Glu  Thr Tyr Gly 
    1460                 1465                 1470             


Phe Ile  Gln Val Thr Leu Leu  Asp Thr Met Glu Leu  Ala Thr Phe 
    1475                 1480                 1485             


Cys Val  Arg Thr Phe Ser Leu  His Lys Asn Gly Ser  Ser Glu Lys 
    1490                 1495                 1500             


Arg Glu  Val Arg His Phe Gln  Phe Thr Ala Trp Pro  Asp His Gly 
    1505                 1510                 1515             


Val Pro  Glu Tyr Pro Thr Pro  Phe Leu Ala Phe Leu  Arg Arg Val 
    1520                 1525                 1530             


Lys Thr  Cys Asn Pro Pro Asp  Ala Gly Pro Ile Val  Val His Cys 
    1535                 1540                 1545             


Ser Ala  Gly Val Gly Arg Thr  Gly Cys Phe Ile Val  Ile Asp Ala 
    1550                 1555                 1560             


Met Leu  Glu Arg Ile Lys Thr  Glu Lys Thr Val Asp  Val Tyr Gly 
    1565                 1570                 1575             


His Val  Thr Leu Met Arg Ser  Gln Arg Asn Tyr Met  Val Gln Thr 
    1580                 1585                 1590             


Glu Asp  Gln Tyr Gly Phe Ile  His Glu Ala Leu Leu  Glu Ala Val 
    1595                 1600                 1605             


Gly Cys  Gly Asn Thr Glu Val  Pro Ala Arg Ser Leu  Tyr Thr Tyr 
    1610                 1615                 1620             


Ile Gln  Lys Leu Ala Gln Val  Glu Pro Gly Glu His  Val Thr Gly 
    1625                 1630                 1635             


Met Glu  Leu Glu Phe Lys Arg  Leu Ala Ser Ser Lys  Ala His Thr 
    1640                 1645                 1650             


Ser Arg  Phe Ile Thr Ala Ser  Leu Pro Cys Asn Lys  Phe Lys Asn 
    1655                 1660                 1665             


Arg Leu  Val Asn Ile Leu Pro  Tyr Glu Ser Ser Arg  Val Cys Leu 
    1670                 1675                 1680             


Gln Pro  Ile Arg Gly Val Glu  Gly Ser Asp Tyr Ile  Asn Ala Ser 
    1685                 1690                 1695             


Phe Ile  Asp Gly Tyr Arg Gln  Gln Lys Ala Tyr Ile  Ala Thr Gln 
    1700                 1705                 1710             


Gly Pro  Leu Ala Glu Thr Thr  Glu Asp Phe Trp Arg  Ala Leu Trp 
    1715                 1720                 1725             


Glu Asn  Asn Ser Thr Ile Val  Val Met Leu Thr Lys  Leu Arg Glu 
    1730                 1735                 1740             


Met Gly  Arg Glu Lys Cys His  Gln Tyr Trp Pro Ala  Glu Arg Ser 
    1745                 1750                 1755             


Ala Arg  Tyr Gln Tyr Phe Val  Val Asp Pro Met Ala  Glu Tyr Asn 
    1760                 1765                 1770             


Met Pro  Gln Tyr Ile Leu Arg  Glu Phe Lys Val Thr  Asp Ala Arg 
    1775                 1780                 1785             


Asp Gly  Gln Ser Arg Thr Val  Arg Gln Phe Gln Phe  Thr Asp Trp 
    1790                 1795                 1800             


Pro Glu  Gln Gly Ala Pro Lys  Ser Gly Glu Gly Phe  Ile Asp Phe 
    1805                 1810                 1815             


Ile Gly  Gln Val His Lys Thr  Lys Glu Gln Phe Gly  Gln Asp Gly 
    1820                 1825                 1830             


Pro Ile  Ser Val His Cys Ser  Ala Gly Val Gly Arg  Thr Gly Val 
    1835                 1840                 1845             


Phe Ile  Thr Leu Ser Ile Val  Leu Glu Arg Met Arg  Tyr Glu Gly 
    1850                 1855                 1860             


Val Val  Asp Ile Phe Gln Thr  Val Lys Val Leu Arg  Thr Gln Arg 
    1865                 1870                 1875             


Pro Ala  Met Val Gln Thr Glu  Asp Glu Tyr Gln Phe  Cys Phe Gln 
    1880                 1885                 1890             


Ala Ala  Leu Glu Tyr Leu Gly  Ser Phe Asp His Tyr  Ala Thr 
    1895                 1900                 1905         


<210>  5
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Glu Pro Pro Arg Phe Ile Lys Glu Pro Lys Asp Gln Ile Gly Val 
1               5                   10                  15      


Ser Gly Gly Val Ala Ser Phe Val Cys Gln Ala Thr Gly Asp Pro Lys 
            20                  25                  30          


Pro Arg Val Thr Trp Asn Lys Lys Gly Lys Lys Val Asn Ser Gln Arg 
        35                  40                  45              


Phe Glu Thr Ile Glu Phe Asp Glu Ser Ala Gly Ala Val Leu Arg Ile 
    50                  55                  60                  


Gln Pro Leu Arg Thr Pro Arg Asp Glu Asn Val Tyr Glu Cys Val Ala 
65                  70                  75                  80  


Gln Asn Ser Val Gly Glu Ile Thr Val His Ala Lys Leu Thr Val Leu 
                85                  90                  95      


Arg Glu 
        


<210>  6
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  6

Asp Gln Leu Pro Ser Gly Phe Pro Asn Ile Asp Met Gly Pro Gln Leu 
1               5                   10                  15      


Lys Val Val Glu Arg Thr Arg Thr Ala Thr Met Leu Cys Ala Ala Ser 
            20                  25                  30          


Gly Asn Pro Asp Pro Glu Ile Thr Trp Phe Lys Asp Phe Leu Pro Val 
        35                  40                  45              


Asp Pro Ser Ala Ser Asn Gly Arg Ile Lys Gln Leu Arg Ser Glu Thr 
    50                  55                  60                  


Phe Glu Ser Thr Pro Ile Arg Gly Ala Leu Gln Ile Glu Ser Ser Glu 
65                  70                  75                  80  


Glu Thr Asp Gln Gly Lys Tyr Glu Cys Val Ala Thr Asn Ser Ala Gly 
                85                  90                  95      


Val Arg Tyr Ser Ser Pro Ala Asn Leu Tyr Val Arg Glu Leu Arg Glu 
            100                 105                 110         


Val Arg Arg Val Ala 
        115         


<210>  7
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  7

Pro Arg Phe Ser Ile Leu Pro Met Ser His Glu Ile Met Pro Gly Gly 
1               5                   10                  15      


Asn Val Asn Ile Thr Cys Val Ala Val Gly Ser Pro Met Pro Tyr Val 
            20                  25                  30          


Lys Trp Met Gln Gly Ala Glu Asp Leu Thr Pro Glu Asp Asp Met Pro 
        35                  40                  45              


Val Gly Arg Asn Val Leu Glu Leu Thr Asp Val Lys Asp Ser Ala Asn 
    50                  55                  60                  


Tyr Thr Cys Val Ala Met Ser Ser Leu Gly Val Ile Glu Ala Val Ala 
65                  70                  75                  80  


Gln Ile Thr Val Lys Ser Leu Pro Lys Ala 
                85                  90  


<210>  8
<211>  1948
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Pro Thr Trp Gly Pro Gly Met Val Ser Val Val Gly Pro Met 
1               5                   10                  15      


Gly Leu Leu Val Val Leu Leu Val Gly Gly Cys Ala Ala Glu Glu Pro 
            20                  25                  30          


Pro Arg Phe Ile Lys Glu Pro Lys Asp Gln Ile Gly Val Ser Gly Gly 
        35                  40                  45              


Val Ala Ser Phe Val Cys Gln Ala Thr Gly Asp Pro Lys Pro Arg Val 
    50                  55                  60                  


Thr Trp Asn Lys Lys Gly Lys Lys Val Asn Ser Gln Arg Phe Glu Thr 
65                  70                  75                  80  


Ile Glu Phe Asp Glu Ser Ala Gly Ala Val Leu Arg Ile Gln Pro Leu 
                85                  90                  95      


Arg Thr Pro Arg Asp Glu Asn Val Tyr Glu Cys Val Ala Gln Asn Ser 
            100                 105                 110         


Val Gly Glu Ile Thr Val His Ala Lys Leu Thr Val Leu Arg Glu Asp 
        115                 120                 125             


Gln Leu Pro Ser Gly Phe Pro Asn Ile Asp Met Gly Pro Gln Leu Lys 
    130                 135                 140                 


Val Val Glu Arg Thr Arg Thr Ala Thr Met Leu Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Asn Pro Asp Pro Glu Ile Thr Trp Phe Lys Asp Phe Leu Pro Val Asp 
                165                 170                 175     


Pro Ser Ala Ser Asn Gly Arg Ile Lys Gln Leu Arg Ser Glu Thr Phe 
            180                 185                 190         


Glu Ser Thr Pro Ile Arg Gly Ala Leu Gln Ile Glu Ser Ser Glu Glu 
        195                 200                 205             


Thr Asp Gln Gly Lys Tyr Glu Cys Val Ala Thr Asn Ser Ala Gly Val 
    210                 215                 220                 


Arg Tyr Ser Ser Pro Ala Asn Leu Tyr Val Arg Glu Leu Arg Glu Val 
225                 230                 235                 240 


Arg Arg Val Ala Pro Arg Phe Ser Ile Leu Pro Met Ser His Glu Ile 
                245                 250                 255     


Met Pro Gly Gly Asn Val Asn Ile Thr Cys Val Ala Val Gly Ser Pro 
            260                 265                 270         


Met Pro Tyr Val Lys Trp Met Gln Gly Ala Glu Asp Leu Thr Pro Glu 
        275                 280                 285             


Asp Asp Met Pro Val Gly Arg Asn Val Leu Glu Leu Thr Asp Val Lys 
    290                 295                 300                 


Asp Ser Ala Asn Tyr Thr Cys Val Ala Met Ser Ser Leu Gly Val Ile 
305                 310                 315                 320 


Glu Ala Val Ala Gln Ile Thr Val Lys Ser Leu Pro Lys Ala Pro Gly 
                325                 330                 335     


Thr Pro Met Val Thr Glu Asn Thr Ala Thr Ser Ile Thr Ile Thr Trp 
            340                 345                 350         


Asp Ser Gly Asn Pro Asp Pro Val Ser Tyr Tyr Val Ile Glu Tyr Lys 
        355                 360                 365             


Ser Lys Ser Gln Asp Gly Pro Tyr Gln Ile Lys Glu Asp Ile Thr Thr 
    370                 375                 380                 


Thr Arg Tyr Ser Ile Gly Gly Leu Ser Pro Asn Ser Glu Tyr Glu Ile 
385                 390                 395                 400 


Trp Val Ser Ala Val Asn Ser Ile Gly Gln Gly Pro Pro Ser Glu Ser 
                405                 410                 415     


Val Val Thr Arg Thr Gly Glu Gln Ala Pro Ala Ser Ala Pro Arg Asn 
            420                 425                 430         


Val Gln Ala Arg Met Leu Ser Ala Thr Thr Met Ile Val Gln Trp Glu 
        435                 440                 445             


Glu Pro Val Glu Pro Asn Gly Leu Ile Arg Gly Tyr Arg Val Tyr Tyr 
    450                 455                 460                 


Thr Met Glu Pro Glu His Pro Val Gly Asn Trp Gln Lys His Asn Val 
465                 470                 475                 480 


Asp Asp Ser Leu Leu Thr Thr Val Gly Ser Leu Leu Glu Asp Glu Thr 
                485                 490                 495     


Tyr Thr Val Arg Val Leu Ala Phe Thr Ser Val Gly Asp Gly Pro Leu 
            500                 505                 510         


Ser Asp Pro Ile Gln Val Lys Thr Gln Gln Gly Val Pro Gly Gln Pro 
        515                 520                 525             


Met Asn Leu Arg Ala Glu Ala Arg Ser Glu Thr Ser Ile Thr Leu Ser 
    530                 535                 540                 


Trp Ser Pro Pro Arg Gln Glu Ser Ile Ile Lys Tyr Glu Leu Leu Phe 
545                 550                 555                 560 


Arg Glu Gly Asp His Gly Arg Glu Val Gly Arg Thr Phe Asp Pro Thr 
                565                 570                 575     


Thr Ser Tyr Val Val Glu Asp Leu Lys Pro Asn Thr Glu Tyr Ala Phe 
            580                 585                 590         


Arg Leu Ala Ala Arg Ser Pro Gln Gly Leu Gly Ala Phe Thr Pro Val 
        595                 600                 605             


Val Arg Gln Arg Thr Leu Gln Ser Lys Pro Ser Ala Pro Pro Gln Asp 
    610                 615                 620                 


Val Lys Cys Val Ser Val Arg Ser Thr Ala Ile Leu Val Ser Trp Arg 
625                 630                 635                 640 


Pro Pro Pro Pro Glu Thr His Asn Gly Ala Leu Val Gly Tyr Ser Val 
                645                 650                 655     


Arg Tyr Arg Pro Leu Gly Ser Glu Asp Pro Glu Pro Lys Glu Val Asn 
            660                 665                 670         


Gly Ile Pro Pro Thr Thr Thr Gln Ile Leu Leu Glu Ala Leu Glu Lys 
        675                 680                 685             


Trp Thr Gln Tyr Arg Ile Thr Thr Val Ala His Thr Glu Val Gly Pro 
    690                 695                 700                 


Gly Pro Glu Ser Ser Pro Val Val Val Arg Thr Asp Glu Asp Val Pro 
705                 710                 715                 720 


Ser Ala Pro Pro Arg Lys Val Glu Ala Glu Ala Leu Asn Ala Thr Ala 
                725                 730                 735     


Ile Arg Val Leu Trp Arg Ser Pro Ala Pro Gly Arg Gln His Gly Gln 
            740                 745                 750         


Ile Arg Gly Tyr Gln Val His Tyr Val Arg Met Glu Gly Ala Glu Ala 
        755                 760                 765             


Arg Gly Pro Pro Arg Ile Lys Asp Val Met Leu Ala Asp Ala Gln Trp 
    770                 775                 780                 


Glu Thr Asp Asp Thr Ala Glu Tyr Glu Met Val Ile Thr Asn Leu Gln 
785                 790                 795                 800 


Pro Glu Thr Ala Tyr Ser Ile Thr Val Ala Ala Tyr Thr Met Lys Gly 
                805                 810                 815     


Asp Gly Ala Arg Ser Lys Pro Lys Val Val Val Thr Lys Gly Ala Val 
            820                 825                 830         


Leu Gly Arg Pro Thr Leu Ser Val Gln Gln Thr Pro Glu Gly Ser Leu 
        835                 840                 845             


Leu Ala Arg Trp Glu Pro Pro Ala Gly Thr Ala Glu Asp Gln Val Leu 
    850                 855                 860                 


Gly Tyr Arg Leu Gln Phe Gly Arg Glu Asp Ser Thr Pro Leu Ala Thr 
865                 870                 875                 880 


Leu Glu Phe Pro Pro Ser Glu Asp Arg Tyr Thr Ala Ser Gly Val His 
                885                 890                 895     


Lys Gly Ala Thr Tyr Val Phe Arg Leu Ala Ala Arg Ser Arg Gly Gly 
            900                 905                 910         


Leu Gly Glu Glu Ala Ala Glu Val Leu Ser Ile Pro Glu Asp Thr Pro 
        915                 920                 925             


Arg Gly His Pro Gln Ile Leu Glu Ala Ala Gly Asn Ala Ser Ala Gly 
    930                 935                 940                 


Thr Val Leu Leu Arg Trp Leu Pro Pro Val Pro Ala Glu Arg Asn Gly 
945                 950                 955                 960 


Ala Ile Val Lys Tyr Thr Val Ala Val Arg Glu Ala Gly Ala Leu Gly 
                965                 970                 975     


Pro Ala Arg Glu Thr Glu Leu Pro Ala Ala Ala Glu Pro Gly Ala Glu 
            980                 985                 990         


Asn Ala Leu Thr Leu Gln Gly Leu  Lys Pro Asp Thr Ala  Tyr Asp Leu 
        995                 1000                 1005             


Gln Val  Arg Ala His Thr Arg  Arg Gly Pro Gly Pro  Phe Ser Pro 
    1010                 1015                 1020             


Pro Val  Arg Tyr Arg Thr Phe  Leu Arg Asp Gln Val  Ser Pro Lys 
    1025                 1030                 1035             


Asn Phe  Lys Val Lys Met Ile  Met Lys Thr Ser Val  Leu Leu Ser 
    1040                 1045                 1050             


Trp Glu  Phe Pro Asp Asn Tyr  Asn Ser Pro Thr Pro  Tyr Lys Ile 
    1055                 1060                 1065             


Gln Tyr  Asn Gly Leu Thr Leu  Asp Val Asp Gly Arg  Thr Thr Lys 
    1070                 1075                 1080             


Lys Leu  Ile Thr His Leu Lys  Pro His Thr Phe Tyr  Asn Phe Val 
    1085                 1090                 1095             


Leu Thr  Asn Arg Gly Ser Ser  Leu Gly Gly Leu Gln  Gln Thr Val 
    1100                 1105                 1110             


Thr Ala  Trp Thr Ala Phe Asn  Leu Leu Asn Gly Lys  Pro Ser Val 
    1115                 1120                 1125             


Ala Pro  Lys Pro Asp Ala Asp  Gly Phe Ile Met Val  Tyr Leu Pro 
    1130                 1135                 1140             


Asp Gly  Gln Ser Pro Val Pro  Val Gln Ser Tyr Phe  Ile Val Met 
    1145                 1150                 1155             


Val Pro  Leu Arg Lys Ser Arg  Gly Gly Gln Phe Leu  Thr Pro Leu 
    1160                 1165                 1170             


Gly Ser  Pro Glu Asp Met Asp  Leu Glu Glu Leu Ile  Gln Asp Ile 
    1175                 1180                 1185             


Ser Arg  Leu Gln Arg Arg Ser  Leu Arg His Ser Arg  Gln Leu Glu 
    1190                 1195                 1200             


Val Pro  Arg Pro Tyr Ile Ala  Ala Arg Phe Ser Val  Leu Pro Pro 
    1205                 1210                 1215             


Thr Phe  His Pro Gly Asp Gln  Lys Gln Tyr Gly Gly  Phe Asp Asn 
    1220                 1225                 1230             


Arg Gly  Leu Glu Pro Gly His  Arg Tyr Val Leu Phe  Val Leu Ala 
    1235                 1240                 1245             


Val Leu  Gln Lys Ser Glu Pro  Thr Phe Ala Ala Ser  Pro Phe Ser 
    1250                 1255                 1260             


Asp Pro  Phe Gln Leu Asp Asn  Pro Asp Pro Gln Pro  Ile Val Asp 
    1265                 1270                 1275             


Gly Glu  Glu Gly Leu Ile Trp  Val Ile Gly Pro Val  Leu Ala Val 
    1280                 1285                 1290             


Val Phe  Ile Ile Cys Ile Val  Ile Ala Ile Leu Leu  Tyr Lys Asn 
    1295                 1300                 1305             


Lys Pro  Asp Ser Lys Arg Lys  Asp Ser Glu Pro Arg  Thr Lys Cys 
    1310                 1315                 1320             


Leu Leu  Asn Asn Ala Asp Leu  Ala Pro His His Pro  Lys Asp Pro 
    1325                 1330                 1335             


Val Glu  Met Arg Arg Ile Asn  Phe Gln Thr Pro Asp  Ser Gly Leu 
    1340                 1345                 1350             


Arg Ser  Pro Leu Arg Glu Pro  Gly Phe His Phe Glu  Ser Met Leu 
    1355                 1360                 1365             


Ser His  Pro Pro Ile Pro Ile  Ala Asp Met Ala Glu  His Thr Glu 
    1370                 1375                 1380             


Arg Leu  Lys Ala Asn Asp Ser  Leu Lys Leu Ser Gln  Glu Tyr Glu 
    1385                 1390                 1395             


Ser Ile  Asp Pro Gly Gln Gln  Phe Thr Trp Glu His  Ser Asn Leu 
    1400                 1405                 1410             


Glu Val  Asn Lys Pro Lys Asn  Arg Tyr Ala Asn Val  Ile Ala Tyr 
    1415                 1420                 1425             


Asp His  Ser Arg Val Ile Leu  Gln Pro Ile Glu Gly  Ile Met Gly 
    1430                 1435                 1440             


Ser Asp  Tyr Ile Asn Ala Asn  Tyr Val Asp Gly Tyr  Arg Cys Gln 
    1445                 1450                 1455             


Asn Ala  Tyr Ile Ala Thr Gln  Gly Pro Leu Pro Glu  Thr Phe Gly 
    1460                 1465                 1470             


Asp Phe  Trp Arg Met Val Trp  Glu Gln Arg Ser Ala  Thr Ile Val 
    1475                 1480                 1485             


Met Met  Thr Arg Leu Glu Glu  Lys Ser Arg Ile Lys  Cys Asp Gln 
    1490                 1495                 1500             


Tyr Trp  Pro Asn Arg Gly Thr  Glu Thr Tyr Gly Phe  Ile Gln Val 
    1505                 1510                 1515             


Thr Leu  Leu Asp Thr Ile Glu  Leu Ala Thr Phe Cys  Val Arg Thr 
    1520                 1525                 1530             


Phe Ser  Leu His Lys Asn Gly  Ser Ser Glu Lys Arg  Glu Val Arg 
    1535                 1540                 1545             


Gln Phe  Gln Phe Thr Ala Trp  Pro Asp His Gly Val  Pro Glu Tyr 
    1550                 1555                 1560             


Pro Thr  Pro Phe Leu Ala Phe  Leu Arg Arg Val Lys  Thr Cys Asn 
    1565                 1570                 1575             


Pro Pro  Asp Ala Gly Pro Ile  Val Val His Cys Ser  Ala Gly Val 
    1580                 1585                 1590             


Gly Arg  Thr Gly Cys Phe Ile  Val Ile Asp Ala Met  Leu Glu Arg 
    1595                 1600                 1605             


Ile Lys  Pro Glu Lys Thr Val  Asp Val Tyr Gly His  Val Thr Leu 
    1610                 1615                 1620             


Met Arg  Ser Gln Arg Asn Tyr  Met Val Gln Thr Glu  Asp Gln Tyr 
    1625                 1630                 1635             


Ser Phe  Ile His Glu Ala Leu  Leu Glu Ala Val Gly  Cys Gly Asn 
    1640                 1645                 1650             


Thr Glu  Val Pro Ala Arg Ser  Leu Tyr Ala Tyr Ile  Gln Lys Leu 
    1655                 1660                 1665             


Ala Gln  Val Glu Pro Gly Glu  His Val Thr Gly Met  Glu Leu Glu 
    1670                 1675                 1680             


Phe Lys  Arg Leu Ala Asn Ser  Lys Ala His Thr Ser  Arg Phe Ile 
    1685                 1690                 1695             


Ser Ala  Asn Leu Pro Cys Asn  Lys Phe Lys Asn Arg  Leu Val Asn 
    1700                 1705                 1710             


Ile Met  Pro Tyr Glu Ser Thr  Arg Val Cys Leu Gln  Pro Ile Arg 
    1715                 1720                 1725             


Gly Val  Glu Gly Ser Asp Tyr  Ile Asn Ala Ser Phe  Ile Asp Gly 
    1730                 1735                 1740             


Tyr Arg  Gln Gln Lys Ala Tyr  Ile Ala Thr Gln Gly  Pro Leu Ala 
    1745                 1750                 1755             


Glu Thr  Thr Glu Asp Phe Trp  Arg Met Leu Trp Glu  Asn Asn Ser 
    1760                 1765                 1770             


Thr Ile  Val Val Met Leu Thr  Lys Leu Arg Glu Met  Gly Arg Glu 
    1775                 1780                 1785             


Lys Cys  His Gln Tyr Trp Pro  Ala Glu Arg Ser Ala  Arg Tyr Gln 
    1790                 1795                 1800             


Tyr Phe  Val Val Asp Pro Met  Ala Glu Tyr Asn Met  Pro Gln Tyr 
    1805                 1810                 1815             


Ile Leu  Arg Glu Phe Lys Val  Thr Asp Ala Arg Asp  Gly Gln Ser 
    1820                 1825                 1830             


Arg Thr  Val Arg Gln Phe Gln  Phe Thr Asp Trp Pro  Glu Gln Gly 
    1835                 1840                 1845             


Val Pro  Lys Ser Gly Glu Gly  Phe Ile Asp Phe Ile  Gly Gln Val 
    1850                 1855                 1860             


His Lys  Thr Lys Glu Gln Phe  Gly Gln Asp Gly Pro  Ile Ser Val 
    1865                 1870                 1875             


His Cys  Ser Ala Gly Val Gly  Arg Thr Gly Val Phe  Ile Thr Leu 
    1880                 1885                 1890             


Ser Ile  Val Leu Glu Arg Met  Arg Tyr Glu Gly Val  Val Asp Ile 
    1895                 1900                 1905             


Phe Gln  Thr Val Lys Met Leu  Arg Thr Gln Arg Pro  Ala Met Val 
    1910                 1915                 1920             


Gln Thr  Glu Asp Glu Tyr Gln  Phe Cys Tyr Gln Ala  Ala Leu Glu 
    1925                 1930                 1935             


Tyr Leu  Gly Ser Phe Asp His  Tyr Ala Thr 
    1940                 1945             


<210>  9
<211>  1228
<212>  PRT
<213>  Mus musculus

<400>  9

Glu Glu Pro Pro Arg Phe Ile Arg Glu Pro Lys Asp Gln Ile Gly Val 
1               5                   10                  15      


Ser Gly Gly Val Ala Ser Phe Val Cys Gln Ala Thr Gly Asp Pro Lys 
            20                  25                  30          


Pro Arg Val Thr Trp Asn Lys Lys Gly Lys Lys Val Asn Ser Gln Arg 
        35                  40                  45              


Phe Glu Thr Ile Asp Phe Asp Glu Ser Ser Gly Ala Val Leu Arg Ile 
    50                  55                  60                  


Gln Pro Leu Arg Thr Pro Arg Asp Glu Asn Val Tyr Glu Cys Val Ala 
65                  70                  75                  80  


Gln Asn Ser Val Gly Glu Ile Thr Ile His Ala Lys Leu Thr Val Leu 
                85                  90                  95      


Arg Glu Asp Gln Leu Pro Pro Gly Phe Pro Asn Ile Asp Met Gly Pro 
            100                 105                 110         


Gln Leu Lys Val Val Glu Arg Thr Arg Thr Ala Thr Met Leu Cys Ala 
        115                 120                 125             


Ala Ser Gly Asn Pro Asp Pro Glu Ile Thr Trp Phe Lys Asp Phe Leu 
    130                 135                 140                 


Pro Val Asp Pro Ser Ala Ser Asn Gly Arg Ile Lys Gln Leu Arg Ser 
145                 150                 155                 160 


Gly Ala Leu Gln Ile Glu Ser Ser Glu Glu Thr Asp Gln Gly Lys Tyr 
                165                 170                 175     


Glu Cys Val Ala Thr Asn Ser Ala Gly Val Arg Tyr Ser Ser Pro Ala 
            180                 185                 190         


Asn Leu Tyr Val Arg Val Arg Arg Val Ala Pro Arg Phe Ser Ile Leu 
        195                 200                 205             


Pro Met Ser His Glu Ile Met Pro Gly Gly Asn Val Asn Ile Thr Cys 
    210                 215                 220                 


Val Ala Val Gly Ser Pro Met Pro Tyr Val Lys Trp Met Gln Gly Ala 
225                 230                 235                 240 


Glu Asp Leu Thr Pro Glu Asp Asp Met Pro Val Gly Arg Asn Val Leu 
                245                 250                 255     


Glu Leu Thr Asp Val Lys Asp Ser Ala Asn Tyr Thr Cys Val Ala Met 
            260                 265                 270         


Ser Ser Leu Gly Val Ile Glu Ala Val Ala Gln Ile Thr Val Lys Ser 
        275                 280                 285             


Leu Pro Lys Ala Pro Gly Thr Pro Val Val Thr Glu Asn Thr Ala Thr 
    290                 295                 300                 


Ser Ile Thr Val Thr Trp Asp Ser Gly Asn Pro Asp Pro Val Ser Tyr 
305                 310                 315                 320 


Tyr Val Ile Glu Tyr Lys Ser Lys Ser Gln Asp Gly Pro Tyr Gln Ile 
                325                 330                 335     


Lys Glu Asp Ile Thr Thr Thr Arg Tyr Ser Ile Gly Gly Leu Ser Pro 
            340                 345                 350         


Asn Ser Glu Tyr Glu Ile Trp Val Ser Ala Val Asn Ser Ile Gly Gln 
        355                 360                 365             


Gly Pro Pro Ser Glu Ser Val Val Thr Arg Thr Gly Glu Gln Ala Pro 
    370                 375                 380                 


Ala Ser Ala Pro Arg Asn Val Gln Ala Arg Met Leu Ser Ala Thr Thr 
385                 390                 395                 400 


Met Ile Val Gln Trp Glu Glu Pro Val Glu Pro Asn Gly Leu Ile Arg 
                405                 410                 415     


Gly Tyr Arg Val Tyr Tyr Thr Met Glu Pro Glu His Pro Val Gly Asn 
            420                 425                 430         


Trp Gln Lys His Asn Val Asp Asp Ser Leu Leu Thr Thr Val Gly Ser 
        435                 440                 445             


Leu Leu Glu Asp Glu Thr Tyr Thr Val Arg Val Leu Ala Phe Thr Ser 
    450                 455                 460                 


Val Gly Asp Gly Pro Leu Ser Asp Pro Ile Gln Val Lys Thr Gln Gln 
465                 470                 475                 480 


Gly Val Pro Gly Gln Pro Met Asn Leu Arg Ala Glu Ala Lys Ser Glu 
                485                 490                 495     


Thr Ser Ile Gly Leu Ser Trp Ser Ala Pro Arg Gln Glu Ser Val Ile 
            500                 505                 510         


Lys Tyr Glu Leu Leu Phe Arg Glu Gly Asp Arg Gly Arg Glu Val Gly 
        515                 520                 525             


Arg Thr Phe Asp Pro Thr Thr Ala Phe Val Val Glu Asp Leu Lys Pro 
    530                 535                 540                 


Asn Thr Glu Tyr Ala Phe Arg Leu Ala Ala Arg Ser Pro Gln Gly Leu 
545                 550                 555                 560 


Gly Ala Phe Thr Ala Val Val Arg Gln Arg Thr Leu Gln Ala Lys Pro 
                565                 570                 575     


Ser Ala Pro Pro Gln Asp Val Lys Cys Thr Ser Leu Arg Ser Thr Ala 
            580                 585                 590         


Ile Leu Val Ser Trp Arg Pro Pro Pro Pro Glu Thr His Asn Gly Ala 
        595                 600                 605             


Leu Val Gly Tyr Ser Val Arg Tyr Arg Pro Leu Gly Ser Glu Asp Pro 
    610                 615                 620                 


Asp Pro Lys Glu Val Asn Asn Ile Pro Pro Thr Thr Thr Gln Ile Leu 
625                 630                 635                 640 


Leu Glu Ala Leu Glu Lys Trp Thr Glu Tyr Arg Val Thr Ala Val Ala 
                645                 650                 655     


Tyr Thr Glu Val Gly Pro Gly Pro Glu Ser Ser Pro Val Val Val Arg 
            660                 665                 670         


Thr Asp Glu Asp Val Pro Ser Ala Pro Pro Arg Lys Val Glu Ala Glu 
        675                 680                 685             


Ala Leu Asn Ala Thr Ala Ile Arg Val Leu Trp Arg Ser Pro Thr Pro 
    690                 695                 700                 


Gly Arg Gln His Gly Gln Ile Arg Gly Tyr Gln Val His Tyr Val Arg 
705                 710                 715                 720 


Met Glu Gly Ala Glu Ala Arg Gly Pro Pro Arg Ile Lys Asp Ile Met 
                725                 730                 735     


Leu Ala Asp Ala Gln Glu Met Val Ile Thr Asn Leu Gln Pro Glu Thr 
            740                 745                 750         


Ala Tyr Ser Ile Thr Val Ala Ala Tyr Thr Met Lys Gly Asp Gly Ala 
        755                 760                 765             


Arg Ser Lys Pro Lys Val Val Val Thr Lys Gly Ala Val Leu Gly Arg 
    770                 775                 780                 


Pro Thr Leu Ser Val Gln Gln Thr Pro Glu Gly Ser Leu Leu Ala Arg 
785                 790                 795                 800 


Trp Glu Pro Pro Ala Asp Ala Ala Glu Asp Pro Val Leu Gly Tyr Arg 
                805                 810                 815     


Leu Gln Phe Gly Arg Glu Asp Ala Ala Pro Ala Thr Leu Glu Leu Ala 
            820                 825                 830         


Ala Trp Glu Arg Arg Phe Ala Ala Pro Ala His Lys Gly Ala Thr Tyr 
        835                 840                 845             


Val Phe Arg Leu Ala Ala Arg Gly Arg Ala Gly Leu Gly Glu Glu Ala 
    850                 855                 860                 


Ala Ala Ala Leu Ser Ile Pro Glu Asp Ala Pro Arg Gly Phe Pro Gln 
865                 870                 875                 880 


Ile Leu Gly Ala Ala Gly Asn Val Ser Ala Gly Ser Val Leu Leu Arg 
                885                 890                 895     


Trp Leu Pro Pro Val Pro Ala Glu Arg Asn Gly Ala Ile Ile Lys Tyr 
            900                 905                 910         


Thr Val Ser Val Arg Glu Ala Gly Ala Pro Gly Pro Ala Thr Glu Thr 
        915                 920                 925             


Glu Leu Ala Ala Ala Ala Gln Pro Gly Ala Glu Thr Ala Leu Thr Leu 
    930                 935                 940                 


Arg Gly Leu Arg Pro Glu Thr Ala Tyr Glu Leu Arg Val Arg Ala His 
945                 950                 955                 960 


Thr Arg Arg Gly Pro Gly Pro Phe Ser Pro Pro Leu Arg Tyr Arg Leu 
                965                 970                 975     


Ala Arg Asp Pro Val Ser Pro Lys Asn Phe Lys Val Lys Met Ile Met 
            980                 985                 990         


Lys Thr Ser Val Leu Leu Ser Trp  Glu Phe Pro Asp Asn  Tyr Asn Ser 
        995                 1000                 1005             


Pro Thr  Pro Tyr Lys Ile Gln  Tyr Asn Gly Leu Thr  Leu Asp Val 
    1010                 1015                 1020             


Asp Gly  Arg Thr Thr Lys Lys  Leu Ile Thr His Leu  Lys Pro His 
    1025                 1030                 1035             


Thr Phe  Tyr Asn Phe Val Leu  Thr Asn Arg Gly Ser  Ser Leu Gly 
    1040                 1045                 1050             


Gly Leu  Gln Gln Thr Val Thr  Ala Arg Thr Ala Phe  Asn Met Leu 
    1055                 1060                 1065             


Ser Gly  Lys Pro Ser Val Ala  Pro Lys Pro Asp Asn  Asp Gly Phe 
    1070                 1075                 1080             


Ile Val  Val Tyr Leu Pro Asp  Gly Gln Ser Pro Val  Thr Val Gln 
    1085                 1090                 1095             


Asn Tyr  Phe Ile Val Met Val  Pro Leu Arg Lys Ser  Arg Gly Gly 
    1100                 1105                 1110             


Gln Phe  Pro Val Leu Leu Gly  Ser Pro Glu Asp Met  Asp Leu Glu 
    1115                 1120                 1125             


Glu Leu  Ile Gln Asp Ile Ser  Arg Leu Gln Arg Arg  Ser Leu Arg 
    1130                 1135                 1140             


His Ser  Arg Gln Leu Glu Val  Pro Arg Pro Tyr Ile  Ala Ala Arg 
    1145                 1150                 1155             


Phe Ser  Ile Leu Pro Ala Val  Phe His Pro Gly Asn  Gln Lys Gln 
    1160                 1165                 1170             


Tyr Gly  Gly Phe Asp Asn Arg  Gly Leu Glu Pro Gly  His Arg Tyr 
    1175                 1180                 1185             


Val Leu  Phe Val Leu Ala Val  Leu Gln Lys Asn Glu  Pro Thr Phe 
    1190                 1195                 1200             


Ala Ala  Ser Pro Phe Ser Asp  Pro Phe Gln Leu Asp  Asn Pro Asp 
    1205                 1210                 1215             


Pro Gln  Pro Ile Val Asp Gly  Glu Glu Gly 
    1220                 1225             


<210>  10
<211>  1253
<212>  PRT
<213>  Homo sapiens

<400>  10

Glu Glu Pro Pro Arg Phe Ile Lys Glu Pro Lys Asp Gln Ile Gly Val 
1               5                   10                  15      


Ser Gly Gly Val Ala Ser Phe Val Cys Gln Ala Thr Gly Asp Pro Lys 
            20                  25                  30          


Pro Arg Val Thr Trp Asn Lys Lys Gly Lys Lys Val Asn Ser Gln Arg 
        35                  40                  45              


Phe Glu Thr Ile Glu Phe Asp Glu Ser Ala Gly Ala Val Leu Arg Ile 
    50                  55                  60                  


Gln Pro Leu Arg Thr Pro Arg Asp Glu Asn Val Tyr Glu Cys Val Ala 
65                  70                  75                  80  


Gln Asn Ser Val Gly Glu Ile Thr Val His Ala Lys Leu Thr Val Leu 
                85                  90                  95      


Arg Glu Asp Gln Leu Pro Ser Gly Phe Pro Asn Ile Asp Met Gly Pro 
            100                 105                 110         


Gln Leu Lys Val Val Glu Arg Thr Arg Thr Ala Thr Met Leu Cys Ala 
        115                 120                 125             


Ala Ser Gly Asn Pro Asp Pro Glu Ile Thr Trp Phe Lys Asp Phe Leu 
    130                 135                 140                 


Pro Val Asp Pro Ser Ala Ser Asn Gly Arg Ile Lys Gln Leu Arg Ser 
145                 150                 155                 160 


Glu Thr Phe Glu Ser Thr Pro Ile Arg Gly Ala Leu Gln Ile Glu Ser 
                165                 170                 175     


Ser Glu Glu Thr Asp Gln Gly Lys Tyr Glu Cys Val Ala Thr Asn Ser 
            180                 185                 190         


Ala Gly Val Arg Tyr Ser Ser Pro Ala Asn Leu Tyr Val Arg Glu Leu 
        195                 200                 205             


Arg Glu Val Arg Arg Val Ala Pro Arg Phe Ser Ile Leu Pro Met Ser 
    210                 215                 220                 


His Glu Ile Met Pro Gly Gly Asn Val Asn Ile Thr Cys Val Ala Val 
225                 230                 235                 240 


Gly Ser Pro Met Pro Tyr Val Lys Trp Met Gln Gly Ala Glu Asp Leu 
                245                 250                 255     


Thr Pro Glu Asp Asp Met Pro Val Gly Arg Asn Val Leu Glu Leu Thr 
            260                 265                 270         


Asp Val Lys Asp Ser Ala Asn Tyr Thr Cys Val Ala Met Ser Ser Leu 
        275                 280                 285             


Gly Val Ile Glu Ala Val Ala Gln Ile Thr Val Lys Ser Leu Pro Lys 
    290                 295                 300                 


Ala Pro Gly Thr Pro Met Val Thr Glu Asn Thr Ala Thr Ser Ile Thr 
305                 310                 315                 320 


Ile Thr Trp Asp Ser Gly Asn Pro Asp Pro Val Ser Tyr Tyr Val Ile 
                325                 330                 335     


Glu Tyr Lys Ser Lys Ser Gln Asp Gly Pro Tyr Gln Ile Lys Glu Asp 
            340                 345                 350         


Ile Thr Thr Thr Arg Tyr Ser Ile Gly Gly Leu Ser Pro Asn Ser Glu 
        355                 360                 365             


Tyr Glu Ile Trp Val Ser Ala Val Asn Ser Ile Gly Gln Gly Pro Pro 
    370                 375                 380                 


Ser Glu Ser Val Val Thr Arg Thr Gly Glu Gln Ala Pro Ala Ser Ala 
385                 390                 395                 400 


Pro Arg Asn Val Gln Ala Arg Met Leu Ser Ala Thr Thr Met Ile Val 
                405                 410                 415     


Gln Trp Glu Glu Pro Val Glu Pro Asn Gly Leu Ile Arg Gly Tyr Arg 
            420                 425                 430         


Val Tyr Tyr Thr Met Glu Pro Glu His Pro Val Gly Asn Trp Gln Lys 
        435                 440                 445             


His Asn Val Asp Asp Ser Leu Leu Thr Thr Val Gly Ser Leu Leu Glu 
    450                 455                 460                 


Asp Glu Thr Tyr Thr Val Arg Val Leu Ala Phe Thr Ser Val Gly Asp 
465                 470                 475                 480 


Gly Pro Leu Ser Asp Pro Ile Gln Val Lys Thr Gln Gln Gly Val Pro 
                485                 490                 495     


Gly Gln Pro Met Asn Leu Arg Ala Glu Ala Arg Ser Glu Thr Ser Ile 
            500                 505                 510         


Thr Leu Ser Trp Ser Pro Pro Arg Gln Glu Ser Ile Ile Lys Tyr Glu 
        515                 520                 525             


Leu Leu Phe Arg Glu Gly Asp His Gly Arg Glu Val Gly Arg Thr Phe 
    530                 535                 540                 


Asp Pro Thr Thr Ser Tyr Val Val Glu Asp Leu Lys Pro Asn Thr Glu 
545                 550                 555                 560 


Tyr Ala Phe Arg Leu Ala Ala Arg Ser Pro Gln Gly Leu Gly Ala Phe 
                565                 570                 575     


Thr Pro Val Val Arg Gln Arg Thr Leu Gln Ser Lys Pro Ser Ala Pro 
            580                 585                 590         


Pro Gln Asp Val Lys Cys Val Ser Val Arg Ser Thr Ala Ile Leu Val 
        595                 600                 605             


Ser Trp Arg Pro Pro Pro Pro Glu Thr His Asn Gly Ala Leu Val Gly 
    610                 615                 620                 


Tyr Ser Val Arg Tyr Arg Pro Leu Gly Ser Glu Asp Pro Glu Pro Lys 
625                 630                 635                 640 


Glu Val Asn Gly Ile Pro Pro Thr Thr Thr Gln Ile Leu Leu Glu Ala 
                645                 650                 655     


Leu Glu Lys Trp Thr Gln Tyr Arg Ile Thr Thr Val Ala His Thr Glu 
            660                 665                 670         


Val Gly Pro Gly Pro Glu Ser Ser Pro Val Val Val Arg Thr Asp Glu 
        675                 680                 685             


Asp Val Pro Ser Ala Pro Pro Arg Lys Val Glu Ala Glu Ala Leu Asn 
    690                 695                 700                 


Ala Thr Ala Ile Arg Val Leu Trp Arg Ser Pro Ala Pro Gly Arg Gln 
705                 710                 715                 720 


His Gly Gln Ile Arg Gly Tyr Gln Val His Tyr Val Arg Met Glu Gly 
                725                 730                 735     


Ala Glu Ala Arg Gly Pro Pro Arg Ile Lys Asp Val Met Leu Ala Asp 
            740                 745                 750         


Ala Gln Trp Glu Thr Asp Asp Thr Ala Glu Tyr Glu Met Val Ile Thr 
        755                 760                 765             


Asn Leu Gln Pro Glu Thr Ala Tyr Ser Ile Thr Val Ala Ala Tyr Thr 
    770                 775                 780                 


Met Lys Gly Asp Gly Ala Arg Ser Lys Pro Lys Val Val Val Thr Lys 
785                 790                 795                 800 


Gly Ala Val Leu Gly Arg Pro Thr Leu Ser Val Gln Gln Thr Pro Glu 
                805                 810                 815     


Gly Ser Leu Leu Ala Arg Trp Glu Pro Pro Ala Gly Thr Ala Glu Asp 
            820                 825                 830         


Gln Val Leu Gly Tyr Arg Leu Gln Phe Gly Arg Glu Asp Ser Thr Pro 
        835                 840                 845             


Leu Ala Thr Leu Glu Phe Pro Pro Ser Glu Asp Arg Tyr Thr Ala Ser 
    850                 855                 860                 


Gly Val His Lys Gly Ala Thr Tyr Val Phe Arg Leu Ala Ala Arg Ser 
865                 870                 875                 880 


Arg Gly Gly Leu Gly Glu Glu Ala Ala Glu Val Leu Ser Ile Pro Glu 
                885                 890                 895     


Asp Thr Pro Arg Gly His Pro Gln Ile Leu Glu Ala Ala Gly Asn Ala 
            900                 905                 910         


Ser Ala Gly Thr Val Leu Leu Arg Trp Leu Pro Pro Val Pro Ala Glu 
        915                 920                 925             


Arg Asn Gly Ala Ile Val Lys Tyr Thr Val Ala Val Arg Glu Ala Gly 
    930                 935                 940                 


Ala Leu Gly Pro Ala Arg Glu Thr Glu Leu Pro Ala Ala Ala Glu Pro 
945                 950                 955                 960 


Gly Ala Glu Asn Ala Leu Thr Leu Gln Gly Leu Lys Pro Asp Thr Ala 
                965                 970                 975     


Tyr Asp Leu Gln Val Arg Ala His Thr Arg Arg Gly Pro Gly Pro Phe 
            980                 985                 990         


Ser Pro Pro Val Arg Tyr Arg Thr  Phe Leu Arg Asp Gln  Val Ser Pro 
        995                 1000                 1005             


Lys Asn  Phe Lys Val Lys Met  Ile Met Lys Thr Ser  Val Leu Leu 
    1010                 1015                 1020             


Ser Trp  Glu Phe Pro Asp Asn  Tyr Asn Ser Pro Thr  Pro Tyr Lys 
    1025                 1030                 1035             


Ile Gln  Tyr Asn Gly Leu Thr  Leu Asp Val Asp Gly  Arg Thr Thr 
    1040                 1045                 1050             


Lys Lys  Leu Ile Thr His Leu  Lys Pro His Thr Phe  Tyr Asn Phe 
    1055                 1060                 1065             


Val Leu  Thr Asn Arg Gly Ser  Ser Leu Gly Gly Leu  Gln Gln Thr 
    1070                 1075                 1080             


Val Thr  Ala Trp Thr Ala Phe  Asn Leu Leu Asn Gly  Lys Pro Ser 
    1085                 1090                 1095             


Val Ala  Pro Lys Pro Asp Ala  Asp Gly Phe Ile Met  Val Tyr Leu 
    1100                 1105                 1110             


Pro Asp  Gly Gln Ser Pro Val  Pro Val Gln Ser Tyr  Phe Ile Val 
    1115                 1120                 1125             


Met Val  Pro Leu Arg Lys Ser  Arg Gly Gly Gln Phe  Leu Thr Pro 
    1130                 1135                 1140             


Leu Gly  Ser Pro Glu Asp Met  Asp Leu Glu Glu Leu  Ile Gln Asp 
    1145                 1150                 1155             


Ile Ser  Arg Leu Gln Arg Arg  Ser Leu Arg His Ser  Arg Gln Leu 
    1160                 1165                 1170             


Glu Val  Pro Arg Pro Tyr Ile  Ala Ala Arg Phe Ser  Val Leu Pro 
    1175                 1180                 1185             


Pro Thr  Phe His Pro Gly Asp  Gln Lys Gln Tyr Gly  Gly Phe Asp 
    1190                 1195                 1200             


Asn Arg  Gly Leu Glu Pro Gly  His Arg Tyr Val Leu  Phe Val Leu 
    1205                 1210                 1215             


Ala Val  Leu Gln Lys Ser Glu  Pro Thr Phe Ala Ala  Ser Pro Phe 
    1220                 1225                 1230             


Ser Asp  Pro Phe Gln Leu Asp  Asn Pro Asp Pro Gln  Pro Ile Val 
    1235                 1240                 1245             


Asp Gly  Glu Glu Gly 
    1250             


<210>  11
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Pro Lys Asp Gln Ile Gly Val Ser Gly Gly Val Ala Ser Phe Val Cys 
1               5                   10                  15      


Gln Ala Thr Gly Asp Pro Lys Pro Arg Val Thr Trp Asn Lys Lys Gly 
            20                  25                  30          


Lys Lys Val Asn Ser Gln Arg Phe Glu Thr Ile Glu Phe Asp Glu Ser 
        35                  40                  45              


Ala Gly Ala Val Leu Arg Ile Gln Pro Leu Arg Thr Pro Arg Asp Glu 
    50                  55                  60                  


Asn Val Tyr Glu Cys Val Ala Gln Asn Ser Val Gly Glu Ile Thr Val 
65                  70                  75                  80  


His Ala Lys Leu Thr Val 
                85      


<210>  12
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Ala Thr Met Leu Cys Ala Ala Ser Gly Asn Pro Asp Pro Glu Ile Thr 
1               5                   10                  15      


Trp Phe Lys Asp Phe Leu Pro Val Asp Pro Ser Ala Ser Asn Gly Arg 
            20                  25                  30          


Ile Lys Gln Leu Arg Ser Glu Thr Phe Glu Ser Thr Pro Ile Arg Gly 
        35                  40                  45              


Ala Leu Gln Ile Glu Ser Ser Glu Glu Thr Asp Gln Gly Lys Tyr Glu 
    50                  55                  60                  


Cys Val Ala Thr Asn Ser Ala Gly Val Arg Tyr Ser Ser Pro Ala Asn 
65                  70                  75                  80  


Leu Tyr 
        


<210>  13
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Gly Gly Asn Val Asn Ile Thr Cys Val Ala Val Gly Ser Pro Met Pro 
1               5                   10                  15      


Tyr Val Lys Trp Met Gln Gly Ala Glu Asp Leu Thr Pro Glu Asp Asp 
            20                  25                  30          


Met Pro Val Gly Arg Asn Val Leu Glu Leu Thr Asp Val Lys Asp Ser 
        35                  40                  45              


Ala Asn Tyr Thr Cys Val Ala Met Ser Ser Leu Gly Val Ile Glu Ala 
    50                  55                  60                  


Val Ala Gln Ile Thr 
65                  


