                         SEQUENCE LISTING

<110>  MATZUK, MARTIN MATTHEW
       PENG, JIA
 
<120>  GDF9:BMP15 HETERODIMERS FOR ENHANCING FERTILITY

<130>  BAYM.P0082WO

<140>  UNKNOWN
<141>  2013-07-19

<150>  61/674,312
<151>  2012-07-21

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  1365
<212>  DNA
<213>  Homo sapiens

<400>  1
atggcacgtc ccaacaaatt cctcctttgg ttttgctgct ttgcctggct gtgttttcct       60

attagccttg gttctcaggc ttctggggga gaagctcaga ttgctgctag tgctgagttg      120

gaatctgggg ctatgccttg gtccttgctg cagcatatag atgagagaga cagagctggc      180

ctccttcccg cgcttttcaa agttctatct gttgggcgag gtgggtcacc taggctgcag      240

ccagactcca gagctttgca ctacatgaag aagctctata agacatatgc taccaaggaa      300

gggattccta aatccaatag aagtcacctc tacaacactg ttcggctctt caccccctgt      360

acccggcaca agcaggctcc tggagaccag gtaacaggaa tccttccatc agtggaactg      420

ctatttaacc tggatcgcat tactaccgtt gaacacttac tcaagtcagt cttgctgtac      480

aatatcaaca actcagtttc tttttcctct gctgtcaaat gtgtgtgcaa tctaatgata      540

aaggagccaa agtcttctag caggactctc ggcagagctc catactcatt tacctttaac      600

tcacagtttg aatttggaaa gaaacacaaa tggattcaga ttgatgtgac cagcctcctt      660

caacctttag tggcctccaa caagagaagt attcacatgt ctataaattt tacttgcatg      720

aaagaccagc tggagcatcc ttcagcacag aatggtttgt ttaacatgac tctggtgtcc      780

ccctcactga tcttatattt gaatgacaca agtgctcagg cttatcacag ctggtattcc      840

cttcactata aaaggaggcc ttcccagggt cctgaccagg agagaagtct gtctgcctat      900

cctgtgggag aagaggctgc tgaggatggg agatcttccc atcaccgtca ccgcagaggt      960

caggaaactg tcagttctga attgaagaag cccttgggcc cagcttcctt caatctgagt     1020

gaatacttca gacaatttct tcttccccaa aatgagtgtg agctccatga ctttagactt     1080

agctttagtc agctgaagtg ggacaactgg attgtggctc cgcacaggta caaccctcga     1140

tactgtaaag gggactgtcc aagggcagtt ggacatcggt atggctctcc agttcacacc     1200

atggtacaga acatcatcta tgagaagctg gactcctcag tgccaagacc gtcatgtgta     1260

cctgccaaat acagcccctt gagtgttttg accattgagc ccgatggctc aattgcctat     1320

aaagagtacg aagatatgat agctacaaag tgcacctgtc gttaa                     1365


<210>  2
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Arg Pro Asn Lys Phe Leu Leu Trp Phe Cys Cys Phe Ala Trp 
1               5                   10                  15      


Leu Cys Phe Pro Ile Ser Leu Gly Ser Gln Ala Ser Gly Gly Glu Ala 
            20                  25                  30          


Gln Ile Ala Ala Ser Ala Glu Leu Glu Ser Gly Ala Met Pro Trp Ser 
        35                  40                  45              


Leu Leu Gln His Ile Asp Glu Arg Asp Arg Ala Gly Leu Leu Pro Ala 
    50                  55                  60                  


Leu Phe Lys Val Leu Ser Val Gly Arg Gly Gly Ser Pro Arg Leu Gln 
65                  70                  75                  80  


Pro Asp Ser Arg Ala Leu His Tyr Met Lys Lys Leu Tyr Lys Thr Tyr 
                85                  90                  95      


Ala Thr Lys Glu Gly Ile Pro Lys Ser Asn Arg Ser His Leu Tyr Asn 
            100                 105                 110         


Thr Val Arg Leu Phe Thr Pro Cys Thr Arg His Lys Gln Ala Pro Gly 
        115                 120                 125             


Asp Gln Val Thr Gly Ile Leu Pro Ser Val Glu Leu Leu Phe Asn Leu 
    130                 135                 140                 


Asp Arg Ile Thr Thr Val Glu His Leu Leu Lys Ser Val Leu Leu Tyr 
145                 150                 155                 160 


Asn Ile Asn Asn Ser Val Ser Phe Ser Ser Ala Val Lys Cys Val Cys 
                165                 170                 175     


Asn Leu Met Ile Lys Glu Pro Lys Ser Ser Ser Arg Thr Leu Gly Arg 
            180                 185                 190         


Ala Pro Tyr Ser Phe Thr Phe Asn Ser Gln Phe Glu Phe Gly Lys Lys 
        195                 200                 205             


His Lys Trp Ile Gln Ile Asp Val Thr Ser Leu Leu Gln Pro Leu Val 
    210                 215                 220                 


Ala Ser Asn Lys Arg Ser Ile His Met Ser Ile Asn Phe Thr Cys Met 
225                 230                 235                 240 


Lys Asp Gln Leu Glu His Pro Ser Ala Gln Asn Gly Leu Phe Asn Met 
                245                 250                 255     


Thr Leu Val Ser Pro Ser Leu Ile Leu Tyr Leu Asn Asp Thr Ser Ala 
            260                 265                 270         


Gln Ala Tyr His Ser Trp Tyr Ser Leu His Tyr Lys Arg Arg Pro Ser 
        275                 280                 285             


Gln Gly Pro Asp Gln Glu Arg Ser Leu Ser Ala Tyr Pro Val Gly Glu 
    290                 295                 300                 


Glu Ala Ala Glu Asp Gly Arg Ser Ser His His Arg His Arg Arg Gly 
305                 310                 315                 320 


Gln Glu Thr Val Ser Ser Glu Leu Lys Lys Pro Leu Gly Pro Ala Ser 
                325                 330                 335     


Phe Asn Leu Ser Glu Tyr Phe Arg Gln Phe Leu Leu Pro Gln Asn Glu 
            340                 345                 350         


Cys Glu Leu His Asp Phe Arg Leu Ser Phe Ser Gln Leu Lys Trp Asp 
        355                 360                 365             


Asn Trp Ile Val Ala Pro His Arg Tyr Asn Pro Arg Tyr Cys Lys Gly 
    370                 375                 380                 


Asp Cys Pro Arg Ala Val Gly His Arg Tyr Gly Ser Pro Val His Thr 
385                 390                 395                 400 


Met Val Gln Asn Ile Ile Tyr Glu Lys Leu Asp Ser Ser Val Pro Arg 
                405                 410                 415     


Pro Ser Cys Val Pro Ala Lys Tyr Ser Pro Leu Ser Val Leu Thr Ile 
            420                 425                 430         


Glu Pro Asp Gly Ser Ile Ala Tyr Lys Glu Tyr Glu Asp Met Ile Ala 
        435                 440                 445             


Thr Lys Cys Thr Cys Arg 
    450                 


<210>  3
<211>  1179
<212>  DNA
<213>  Homo sapiens

<400>  3
atggtcctcc tcagtattct tagaattctt tttctttgtg aactcgtgct tttcatggaa       60

cacagggccc aaatggcaga aggagggcag tcctctattg cccttctggc tgaggcccct      120

actttgcccc tgattgagga gctgctagaa gaatcccctg gcgaacagcc aaggaagccc      180

cggctcctag ggcattcact gcggtacatg ctggagttgt accggcgttc agctgactcg      240

catgggcacc ctagagagaa ccgcaccatt ggggccacca tggtgaggct ggtgaagccc      300

ttgaccaatg tggcaaggcc tcacagaggt acctggcata tacagatcct gggctttcct      360

ctcagaccaa accgaggact ataccaacta gttagagcca ctgtggttta ccgccatcat      420

ctccaactaa ctcgcttcaa tctctcctgc catgtggagc cctgggtgca gaaaaaccca      480

accaaccact tcccttcctc agaaggagat tcctcaaaac cttccctgat gtctaacgct      540

tggaaagaga tggatatcac acaacttgtt cagcaaaggt tctggaataa caagggacac      600

aggatcctac gactccgttt tatgtgtcag cagcaaaaag atagtggtgg tcttgagctc      660

tggcatggca cttcatcctt ggacattgcc ttcttgttac tctatttcaa tgatactcat      720

aaaagcattc ggaaggctaa atttcttccc aggggcatgg aggagttcat ggaaagggaa      780

tctcttctcc ggagaacccg acaagcagat ggtatctcag ctgaggttac tgcctcttcc      840

tcaaaacata gcgggcctga aaataaccag tgttccctcc accctttcca aatcagcttc      900

cgccagctgg gttgggatca ctggatcatt gctccccctt tctacacccc aaactactgt      960

aaaggaactt gtctccgagt actacgcgat ggtctcaatt cccccaatca cgccattatt     1020

cagaacctta tcaatcagtt ggtggaccag agtgtccccc ggccctcctg tgtcccgtat     1080

aagtatgttc caattagtgt ccttatgatt gaggcaaatg ggagtatttt gtacaaggag     1140

tatgagggta tgattgctga gtcttgtaca tgcagatga                            1179


<210>  4
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Val Leu Leu Ser Ile Leu Arg Ile Leu Phe Leu Cys Glu Leu Val 
1               5                   10                  15      


Leu Phe Met Glu His Arg Ala Gln Met Ala Glu Gly Gly Gln Ser Ser 
            20                  25                  30          


Ile Ala Leu Leu Ala Glu Ala Pro Thr Leu Pro Leu Ile Glu Glu Leu 
        35                  40                  45              


Leu Glu Glu Ser Pro Gly Glu Gln Pro Arg Lys Pro Arg Leu Leu Gly 
    50                  55                  60                  


His Ser Leu Arg Tyr Met Leu Glu Leu Tyr Arg Arg Ser Ala Asp Ser 
65                  70                  75                  80  


His Gly His Pro Arg Glu Asn Arg Thr Ile Gly Ala Thr Met Val Arg 
                85                  90                  95      


Leu Val Lys Pro Leu Thr Asn Val Ala Arg Pro His Arg Gly Thr Trp 
            100                 105                 110         


His Ile Gln Ile Leu Gly Phe Pro Leu Arg Pro Asn Arg Gly Leu Tyr 
        115                 120                 125             


Gln Leu Val Arg Ala Thr Val Val Tyr Arg His His Leu Gln Leu Thr 
    130                 135                 140                 


Arg Phe Asn Leu Ser Cys His Val Glu Pro Trp Val Gln Lys Asn Pro 
145                 150                 155                 160 


Thr Asn His Phe Pro Ser Ser Glu Gly Asp Ser Ser Lys Pro Ser Leu 
                165                 170                 175     


Met Ser Asn Ala Trp Lys Glu Met Asp Ile Thr Gln Leu Val Gln Gln 
            180                 185                 190         


Arg Phe Trp Asn Asn Lys Gly His Arg Ile Leu Arg Leu Arg Phe Met 
        195                 200                 205             


Cys Gln Gln Gln Lys Asp Ser Gly Gly Leu Glu Leu Trp His Gly Thr 
    210                 215                 220                 


Ser Ser Leu Asp Ile Ala Phe Leu Leu Leu Tyr Phe Asn Asp Thr His 
225                 230                 235                 240 


Lys Ser Ile Arg Lys Ala Lys Phe Leu Pro Arg Gly Met Glu Glu Phe 
                245                 250                 255     


Met Glu Arg Glu Ser Leu Leu Arg Arg Thr Arg Gln Ala Asp Gly Ile 
            260                 265                 270         


Ser Ala Glu Val Thr Ala Ser Ser Ser Lys His Ser Gly Pro Glu Asn 
        275                 280                 285             


Asn Gln Cys Ser Leu His Pro Phe Gln Ile Ser Phe Arg Gln Leu Gly 
    290                 295                 300                 


Trp Asp His Trp Ile Ile Ala Pro Pro Phe Tyr Thr Pro Asn Tyr Cys 
305                 310                 315                 320 


Lys Gly Thr Cys Leu Arg Val Leu Arg Asp Gly Leu Asn Ser Pro Asn 
                325                 330                 335     


His Ala Ile Ile Gln Asn Leu Ile Asn Gln Leu Val Asp Gln Ser Val 
            340                 345                 350         


Pro Arg Pro Ser Cys Val Pro Tyr Lys Tyr Val Pro Ile Ser Val Leu 
        355                 360                 365             


Met Ile Glu Ala Asn Gly Ser Ile Leu Tyr Lys Glu Tyr Glu Gly Met 
    370                 375                 380                 


Ile Ala Glu Ser Cys Thr Cys Arg 
385                 390         


<210>  5
<211>  1326
<212>  DNA
<213>  Mus musculus

<400>  5
atggcacttc ccagcaactt cctgttgggg gtttgctgct ttgcctggct gtgttttctt       60

agtagcctta gctctcaggc ttctactgaa gaatcccaga gtggagccag tgaaaatgtg      120

gagtctgagg cagacccctg gtccttgctg ctgcctgtag atgggactga caggtctggc      180

ctcttgcccc ccctctttaa ggttctatct gataggcgag gtgagacccc taagctgcag      240

cctgactcca gagcactcta ctacatgaaa aagctctata agacgtatgc taccaaagag      300

ggggttccca aacccagcag aagtcacctc tacaataccg tccggctctt cagtccctgt      360

gcccagcaag agcaggcacc cagcaaccag gtgacaggac cgctgccgat ggtggacctg      420

ctgtttaacc tggaccgggt gactgccatg gaacacttgc tcaaatcggt cttgctatac      480

actctgaaca actctgcctc ttcctcctcc actgtgacct gtatgtgtga ccttgtggta      540

aaggaggcca tgtcttctgg cagggcaccc ccaagagcac cgtactcatt caccctgaag      600

aaacacagat ggattgagat tgatgtgacc tccctccttc agcccctagt gacctccagc      660

gagaggagca ttcacctgtc tgtcaatttt acatgcacaa aagaccaggt gccagaggac      720

ggagtgttta gcatgcctct ctcagtgcct ccttccctca tcttgtatct caacgacaca      780

agcacccagg cctaccactc ttggcagtct cttcagtcca cctggaggcc tttacagcat      840

cccggccagg ccggtgtggc tgcccgtccc gtgaaagagg aagctattga ggtggaaaga      900

tctccccggc gccgtcgagg gcagaaagcc atccgctccg aagcgaaggg gccacttctt      960

acagcatcct tcaacctcag cgaatacttc aaacagtttc ttttccccca aaacgagtgt     1020

gaactccatg acttcagact gagttttagt cagctcaaat gggacaactg gatcgtggcc     1080

ccgcacaggt acaaccctag gtactgtaaa ggggactgtc ctagggcggt caggcatcgg     1140

tacggctctc ctgtgcacac catggtccag aatataatct atgagaagct ggacccttca     1200

gtgccaaggc cttcgtgtgt gccgggcaag tacagccccc tgagtgtgtt gaccattgaa     1260

cccgacggct ccatcgctta caaagagtac gaagacatga tagctacgag gtgcacctgt     1320

cgttag                                                                1326


<210>  6
<211>  441
<212>  PRT
<213>  Mus musculus

<400>  6

Met Ala Leu Pro Ser Asn Phe Leu Leu Gly Val Cys Cys Phe Ala Trp 
1               5                   10                  15      


Leu Cys Phe Leu Ser Ser Leu Ser Ser Gln Ala Ser Thr Glu Glu Ser 
            20                  25                  30          


Gln Ser Gly Ala Ser Glu Asn Val Glu Ser Glu Ala Asp Pro Trp Ser 
        35                  40                  45              


Leu Leu Leu Pro Val Asp Gly Thr Asp Arg Ser Gly Leu Leu Pro Pro 
    50                  55                  60                  


Leu Phe Lys Val Leu Ser Asp Arg Arg Gly Glu Thr Pro Lys Leu Gln 
65                  70                  75                  80  


Pro Asp Ser Arg Ala Leu Tyr Tyr Met Lys Lys Leu Tyr Lys Thr Tyr 
                85                  90                  95      


Ala Thr Lys Glu Gly Val Pro Lys Pro Ser Arg Ser His Leu Tyr Asn 
            100                 105                 110         


Thr Val Arg Leu Phe Ser Pro Cys Ala Gln Gln Glu Gln Ala Pro Ser 
        115                 120                 125             


Asn Gln Val Thr Gly Pro Leu Pro Met Val Asp Leu Leu Phe Asn Leu 
    130                 135                 140                 


Asp Arg Val Thr Ala Met Glu His Leu Leu Lys Ser Val Leu Leu Tyr 
145                 150                 155                 160 


Thr Leu Asn Asn Ser Ala Ser Ser Ser Ser Thr Val Thr Cys Met Cys 
                165                 170                 175     


Asp Leu Val Val Lys Glu Ala Met Ser Ser Gly Arg Ala Pro Pro Arg 
            180                 185                 190         


Ala Pro Tyr Ser Phe Thr Leu Lys Lys His Arg Trp Ile Glu Ile Asp 
        195                 200                 205             


Val Thr Ser Leu Leu Gln Pro Leu Val Thr Ser Ser Glu Arg Ser Ile 
    210                 215                 220                 


His Leu Ser Val Asn Phe Thr Cys Thr Lys Asp Gln Val Pro Glu Asp 
225                 230                 235                 240 


Gly Val Phe Ser Met Pro Leu Ser Val Pro Pro Ser Leu Ile Leu Tyr 
                245                 250                 255     


Leu Asn Asp Thr Ser Thr Gln Ala Tyr His Ser Trp Gln Ser Leu Gln 
            260                 265                 270         


Ser Thr Trp Arg Pro Leu Gln His Pro Gly Gln Ala Gly Val Ala Ala 
        275                 280                 285             


Arg Pro Val Lys Glu Glu Ala Ile Glu Val Glu Arg Ser Pro Arg Arg 
    290                 295                 300                 


Arg Arg Gly Gln Lys Ala Ile Arg Ser Glu Ala Lys Gly Pro Leu Leu 
305                 310                 315                 320 


Thr Ala Ser Phe Asn Leu Ser Glu Tyr Phe Lys Gln Phe Leu Phe Pro 
                325                 330                 335     


Gln Asn Glu Cys Glu Leu His Asp Phe Arg Leu Ser Phe Ser Gln Leu 
            340                 345                 350         


Lys Trp Asp Asn Trp Ile Val Ala Pro His Arg Tyr Asn Pro Arg Tyr 
        355                 360                 365             


Cys Lys Gly Asp Cys Pro Arg Ala Val Arg His Arg Tyr Gly Ser Pro 
    370                 375                 380                 


Val His Thr Met Val Gln Asn Ile Ile Tyr Glu Lys Leu Asp Pro Ser 
385                 390                 395                 400 


Val Pro Arg Pro Ser Cys Val Pro Gly Lys Tyr Ser Pro Leu Ser Val 
                405                 410                 415     


Leu Thr Ile Glu Pro Asp Gly Ser Ile Ala Tyr Lys Glu Tyr Glu Asp 
            420                 425                 430         


Met Ile Ala Thr Arg Cys Thr Cys Arg 
        435                 440     


<210>  7
<211>  1179
<212>  DNA
<213>  Mus musculus

<400>  7
atggcccttc tcacaattct tagaattctt ttgtggggag tggtgctttt tatggaacag       60

agggtccaaa tggcaaagcc agggtggccc tccaccgccc tccttgctga cgaccctaca      120

ttgccctcaa ttttggatct ggccaaagaa gcccctggca aggagatgaa gcaatggccc      180

caaggctatc ccctgaggta catgctcaag ttataccatc gttcggctga cccgcatggc      240

catccaaggg agaaccgcac gattggagcg aaaatggtga ggctggtaaa gccgtcggcc      300

aacacagtaa ggcctcccag aggttcctgg catgtacaga ccctggactt tcctctagca      360

tcaaaccagg tagcatacga actaatcaga gccactgtgg tttaccgcca tcaacttcat      420

ctagttaatt accatctctc ctgccatgtg gaaacttggg ttcctaaatg ccggaccaag      480

cacttacctt cttctaaatc gggttcctca aagccttctc ccatgtctaa agcctggaca      540

gagatagata ttacacattg tattcagcag aagctctgga atcgcaaggg acggagtgtt      600

cttcgcctcc gcttcatgtg tcagcagcaa aaaggcaatg agactcgtga gttccggtgg      660

catggcatga catccttgga tgttgccttc ttgctactct atttcaatga caccgatgac      720

agagttcagg gtaaacttct tgcaagaggc caagaggagt taactgatag ggaatcttct      780

tttctcatgc ggagtgtccg gcaagcatgc agcattgaat ctgatgcctc ttgtccttct      840

caggaacatg atgggtctgt aaataaccag tgttccctcc atccttacaa ggtcagcttc      900

caccaactag gctgggatca ctggatcatt gctcctcgtc tctatacccc aaattactgt      960

aaaggaatct gtactcgggt attaccctat ggtctcaatt cacccaacca tgccatcatt     1020

cagagccttg tcaatgaact agtgaatcac agtgtacctc agccttcctg tgtcccttat     1080

aattttcttc ctatgagcat cctcctgatt gagaccaacg ggagtatctt gtacaaggag     1140

tatgagggta tgattgccca gtcctgtaca tgtagataa                            1179


<210>  8
<211>  392
<212>  PRT
<213>  Mus musculus

<400>  8

Met Ala Leu Leu Thr Ile Leu Arg Ile Leu Leu Trp Gly Val Val Leu 
1               5                   10                  15      


Phe Met Glu Gln Arg Val Gln Met Ala Lys Pro Gly Trp Pro Ser Thr 
            20                  25                  30          


Ala Leu Leu Ala Asp Asp Pro Thr Leu Pro Ser Ile Leu Asp Leu Ala 
        35                  40                  45              


Lys Glu Ala Pro Gly Lys Glu Met Lys Gln Trp Pro Gln Gly Tyr Pro 
    50                  55                  60                  


Leu Arg Tyr Met Leu Lys Leu Tyr His Arg Ser Ala Asp Pro His Gly 
65                  70                  75                  80  


His Pro Arg Glu Asn Arg Thr Ile Gly Ala Lys Met Val Arg Leu Val 
                85                  90                  95      


Lys Pro Ser Ala Asn Thr Val Arg Pro Pro Arg Gly Ser Trp His Val 
            100                 105                 110         


Gln Thr Leu Asp Phe Pro Leu Ala Ser Asn Gln Val Ala Tyr Glu Leu 
        115                 120                 125             


Ile Arg Ala Thr Val Val Tyr Arg His Gln Leu His Leu Val Asn Tyr 
    130                 135                 140                 


His Leu Ser Cys His Val Glu Thr Trp Val Pro Lys Cys Arg Thr Lys 
145                 150                 155                 160 


His Leu Pro Ser Ser Lys Ser Gly Ser Ser Lys Pro Ser Pro Met Ser 
                165                 170                 175     


Lys Ala Trp Thr Glu Ile Asp Ile Thr His Cys Ile Gln Gln Lys Leu 
            180                 185                 190         


Trp Asn Arg Lys Gly Arg Ser Val Leu Arg Leu Arg Phe Met Cys Gln 
        195                 200                 205             


Gln Gln Lys Gly Asn Glu Thr Arg Glu Phe Arg Trp His Gly Met Thr 
    210                 215                 220                 


Ser Leu Asp Val Ala Phe Leu Leu Leu Tyr Phe Asn Asp Thr Asp Asp 
225                 230                 235                 240 


Arg Val Gln Gly Lys Leu Leu Ala Arg Gly Gln Glu Glu Leu Thr Asp 
                245                 250                 255     


Arg Glu Ser Ser Phe Leu Met Arg Ser Val Arg Gln Ala Cys Ser Ile 
            260                 265                 270         


Glu Ser Asp Ala Ser Cys Pro Ser Gln Glu His Asp Gly Ser Val Asn 
        275                 280                 285             


Asn Gln Cys Ser Leu His Pro Tyr Lys Val Ser Phe His Gln Leu Gly 
    290                 295                 300                 


Trp Asp His Trp Ile Ile Ala Pro Arg Leu Tyr Thr Pro Asn Tyr Cys 
305                 310                 315                 320 


Lys Gly Ile Cys Thr Arg Val Leu Pro Tyr Gly Leu Asn Ser Pro Asn 
                325                 330                 335     


His Ala Ile Ile Gln Ser Leu Val Asn Glu Leu Val Asn His Ser Val 
            340                 345                 350         


Pro Gln Pro Ser Cys Val Pro Tyr Asn Phe Leu Pro Met Ser Ile Leu 
        355                 360                 365             


Leu Ile Glu Thr Asn Gly Ser Ile Leu Tyr Lys Glu Tyr Glu Gly Met 
    370                 375                 380                 


Ile Ala Gln Ser Cys Thr Cys Arg 
385                 390         


<210>  9
<211>  1362
<212>  DNA
<213>  Ovis aries

<400>  9
atggcgcttc ccaacaaatt cttcctttgg ttttgctgct ttgcctggct ctgttttcct       60

attagccttg attctctgcc ttctagggga gaagctcaga ttgtagctag gactgcgttg      120

gaatctgagg ctgagacttg gtccttgctg aaccatttag gtgggagaca cagacctggt      180

ctcctttccc ctctcttaga ggttctgtat gatgggcacg gggaaccccc caggctgcag      240

ccagatgaca gagctttgcg ctacatgaag aggctctata aggcatacgc taccaaggag      300

gggaccccta aatccaacag acgccacctc tacaacactg ttcggctctt caccccctgt      360

gctcagcaca agcaggctcc tggggacctg gcggcaggaa cctttccatc agtggatctg      420

ctgtttaacc tggatcgtgt tactgttgtg gaacatttat tcaagtcagt cttgctgtat      480

actttcaaca actccatttc ttttcccttt cctgttaaat gtatatgcaa cctggtgata      540

aaagagccag agttttctag caagactctc cctagagctc catactcatt tacctataac      600

tcacagtttg aatttagaaa gaaatacaaa tggatggaga ttgatgtgac ggctcctctt      660

gagcctctgg tggcctccca caagaggaat attcacatgt ctgtaaattt tacatgtgcg      720

gaagaccagc tgcagcatcc ttcagcgcgg gacagcctgt ttaacatgac tcttctcgta      780

gcgccctcac tgcttttgta tctgaacgac acaagtgctc aggcttttca caggtggcat      840

tccctccacc ctaaaaggaa gccttcacag ggtcctgacc agaagagagg gctatctgcc      900

taccccgtgg gagaagaagc tgctgagggt gtaagatcgt cccgtcaccg cagagaccag      960

gagagtgcca gctctgaatt gaagaagcct ctggttccag cttcagtcaa tctgagtgaa     1020

tacttcaaac agtgtctttt tccccagaat gaatgtgagc tccatgactt tagacttagc     1080

tttagtcagc tgaagtggga caactggatt gtggccccac acaaatacaa ccctcgatac     1140

tgtaaagggg actgtcccag ggcggtcgga catcggtatg gctctccggt tcacaccatg     1200

gtgcagaaca tcatccatga gaaacttgac tcctcagtgc caagaccatc ctgtgtacct     1260

gccaagtata gccctttgag tgttttggcc atcgagcctg atggctcaat cgcttataaa     1320

gaatatgaag atatgatagc cactaagtgt acctgtcgtt aa                        1362


<210>  10
<211>  302
<212>  PRT
<213>  Ovis aries

<400>  10

Met Ala Asn Lys Trp Cys Cys Ala Trp Cys Ile Ser Asp Ser Ser Arg 
1               5                   10                  15      


Gly Ala Ile Val Ala Arg Thr Ala Ser Ala Thr Trp Ser Asn His Gly 
            20                  25                  30          


Gly Arg His Arg Gly Ser Val Tyr Asp Gly His Gly Arg Asp Asp Arg 
        35                  40                  45              


Ala Arg Tyr Met Lys Arg Tyr Lys Ala Tyr Ala Thr Lys Gly Thr Lys 
    50                  55                  60                  


Ser Asn Arg Arg His Tyr Asn Thr Val Arg Thr Cys Ala His Lys Ala 
65                  70                  75                  80  


Gly Asp Ala Ala Gly Thr Ser Val Asp Asn Asp Arg Val Thr Val Val 
                85                  90                  95      


His Lys Ser Val Tyr Thr Asn Asn Ser Ile Ser Val Lys Cys Ile Cys 
            100                 105                 110         


Asn Val Ile Lys Ser Ser Lys Thr Arg Ala Tyr Ser Thr Tyr Asn Ser 
        115                 120                 125             


Arg Lys Lys Tyr Lys Trp Met Ile Asp Val Thr Ala Val Ala Ser His 
    130                 135                 140                 


Lys Arg Asn Ile His Met Ser Val Asn Thr Cys Ala Asp His Ser Ala 
145                 150                 155                 160 


Arg Asp Ser Asn Met Thr Val Ala Ser Tyr Asn Asp Thr Ser Ala Ala 
                165                 170                 175     


His Arg Trp His Ser His Lys Arg Lys Ser Gly Asp Lys Arg Gly Ser 
            180                 185                 190         


Ala Tyr Val Gly Ala Ala Gly Val Arg Ser Ser Arg His Arg Arg Asp 
        195                 200                 205             


Ser Ala Ser Ser Lys Lys Val Ala Ser Val Asn Ser Tyr Lys Cys Asn 
    210                 215                 220                 


Cys His Asp Arg Ser Ser Lys Trp Asp Asn Trp Ile Val Ala His Lys 
225                 230                 235                 240 


Tyr Asn Arg Tyr Cys Lys Gly Asp Cys Arg Ala Val Gly His Arg Tyr 
                245                 250                 255     


Gly Ser Val His Thr Met Val Asn Ile Ile His Lys Asp Ser Ser Val 
            260                 265                 270         


Arg Ser Cys Val Ala Lys Tyr Ser Ser Val Ala Ile Asp Gly Ser Ile 
        275                 280                 285             


Ala Tyr Lys Tyr Asp Met Ile Ala Thr Lys Cys Thr Cys Arg 
    290                 295                 300         


<210>  11
<211>  1182
<212>  DNA
<213>  Ovis aries

<400>  11
atggtcctcc tgagcatcct tagaatcctt ctttggggac tggtgctttt tatggaacat       60

agggtccaaa tgacacaggt agggcagccc tctattgccc acctgcctga ggcccctacc      120

ttgcccctga ttcaggagct gctagaagaa gcccctggca agcagcagag gaagccgcgg      180

gtcttagggc atcccttacg gtatatgctg gagctgtacc agcgttcagc tgacgcaagt      240

ggacacccta gggaaaaccg caccattggg gccaccatgg tgaggctggt gaggccgctg      300

gctagtgtag caaggcctct cagaggctcc tggcacatac agaccctgga ctttcctctg      360

agaccaaacc gggtagcata ccaactagtc agagccactg tggtttaccg ccatcagctt      420

cacctaactc attcccacct ctcctgccat gtggagccct gggtccagaa aagcccaacc      480

aatcactttc cttcttcagg aagaggctcc tcaaagcctt ccctgttgcc caaaacttgg      540

acagagatgg atatcatgga acatgttggg caaaagctct ggaatcacaa ggggcgcagg      600

gttctacgac tccgcttcgt gtgtcagcag ccaagaggta gtgaggttct tgagttctgg      660

tggcatggca cttcatcatt ggacactgtc ttcttgttac tgtatttcaa tgacactcag      720

agtgttcaga agaccaaacc tctccctaaa ggcctgaaag agtttacaga aaaagaccct      780

tctcttctct tgaggagggc tcgtcaagca ggcagtattg catcggaagt tcctggcccc      840

tccagggagc atgatgggcc tgaaagtaac cagtgttccc tccacccttt tcaagtcagc      900

ttccagcagc tgggctggga tcactggatc attgctcccc atctctatac cccaaactac      960

tgtaagggag tatgtcctcg ggtactacac tatggtctca attctcccaa tcatgccatc     1020

atccagaacc ttgtcagtga gctggtggat cagaatgtcc ctcagccttc ctgtgtccct     1080

tataagtatg ttcccattag catccttctg attgaggcaa atgggagtat cttgtacaag     1140

gagtatgagg gtatgattgc ccagtcctgc acatgcaggt ga                        1182


<210>  12
<211>  254
<212>  PRT
<213>  Ovis aries

<400>  12

Met Val Ser Ile Arg Ile Trp Gly Val Met His Arg Val Met Thr Val 
1               5                   10                  15      


Gly Ser Ile Ala His Ala Thr Ile Ala Gly Lys Arg Lys Arg Val Gly 
            20                  25                  30          


His Arg Tyr Met Tyr Arg Ser Ala Asp Ala Ser Gly His Arg Asn Arg 
        35                  40                  45              


Thr Ile Gly Ala Thr Met Val Arg Val Arg Ala Ser Val Ala Arg Arg 
    50                  55                  60                  


Gly Ser Trp His Ile Thr Asp Arg Asn Arg Val Ala Tyr Val Arg Ala 
65                  70                  75                  80  


Thr Val Val Tyr Arg His His Thr His Ser His Ser Cys His Val Trp 
                85                  90                  95      


Val Lys Ser Thr Asn His Ser Ser Gly Arg Gly Ser Ser Lys Ser Lys 
            100                 105                 110         


Thr Trp Thr Met Asp Ile Met His Val Gly Lys Trp Asn His Lys Gly 
        115                 120                 125             


Arg Arg Val Arg Arg Val Cys Arg Gly Ser Val Trp Trp His Gly Thr 
    130                 135                 140                 


Ser Ser Asp Thr Val Tyr Asn Asp Thr Ser Val Lys Thr Lys Lys Gly 
145                 150                 155                 160 


Lys Thr Lys Asp Ser Arg Arg Ala Arg Ala Gly Ser Ile Ala Ser Val 
                165                 170                 175     


Gly Ser Arg His Asp Gly Ser Asn Cys Ser His Val Ser Gly Trp Asp 
            180                 185                 190         


His Trp Ile Ile Ala His Tyr Thr Asn Tyr Cys Lys Gly Val Cys Arg 
        195                 200                 205             


Val His Tyr Gly Asn Ser Asn His Ala Ile Ile Asn Val Ser Val Asp 
    210                 215                 220                 


Asn Val Ser Cys Val Tyr Lys Tyr Val Ile Ser Ile Ile Ala Asn Gly 
225                 230                 235                 240 


Ser Ile Tyr Lys Tyr Gly Met Ile Ala Ser Cys Thr Cys Arg 
                245                 250                 


