                         SEQUENCE LISTING

<110>  Xenon Pharmaceuticals Inc.
       Franchini, Patrick, Lorenzo, Angelo
       Tietjen, Ian, William
       Hayden, Michael, Reuben
       Singaraja, Roshni, Rebecca
       Radomski, Christopher, Charles, Alexander
       Percival, Michael, David
       Eyers, Maryanne, Sharon
       Dean, Richard, Asher
       Xie, Zhiwei
 
<120>  CYP8B1 AND USES THEREOF IN THERAPEUTIC AND DIAGNOSTIC METHODS

<130>  980057.483WO

<140> PCT
<141> 2013-07-18

<150> US 61/674,721
<151> 2012-07-23

<160>  84    

<170>  PatentIn version 3.5

<210>  1
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  1

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Thr Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  2
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  2
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tacgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  3
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  3

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Glu Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  4
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  4
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgaaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  5
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  5

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asn Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  6
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  6
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcagaac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  7
<211>  299
<212>  PRT
<213>  Homo Sapiens

<400>  7

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu 
    290                 295                 


<210>  8
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  8
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgtagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  9
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  9

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asn Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  10
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  10
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagagag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  11
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  11

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Gln Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  12
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  12
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc agctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  13
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  13

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp His Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  14
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  14
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcacttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  15
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  15

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  16
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  16
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggcccca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  17
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  17

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Arg Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  18
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  18
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacagga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  19
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  19

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Phe Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  20
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  20
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcttcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  21
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  21

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Lys Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  22
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  22
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggaa     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  23
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  23

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Ile Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  24
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  24
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccat cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  25
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  25

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Asn His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  26
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  26
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccacagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  27
<211>  25
<212>  PRT
<213>  Homo Sapiens

<400>  27

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu 
            20                  25  


<210>  28
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  28
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc tgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  29
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  29

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Cys Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  30
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  30
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaatgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  31
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  31

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Gln Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  32
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  32
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccagaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  33
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  33

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Cys Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  34
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  34
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagt gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  35
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  35

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Ile 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  36
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  36
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcatcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  37
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  37

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr 
                85                  90              


<210>  38
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  38
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacatagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  39
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  39

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Val Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  40
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  40
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaagtagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  41
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  41

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Met His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  42
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  42
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca tgcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  43
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  43

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Ala Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  44
<211>  3300
<212>  DNA
<213>  Homo Sapiens

<400>  44
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

ggcggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300


<210>  45
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  45

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Gln Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  46
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  46
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctgggc agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  47
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  47

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Leu Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  48
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  48
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttaggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  49
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  49

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Ser Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  50
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  50
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcagctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  51
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  51

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe His Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  52
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  52
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccacaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  53
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  53

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Met Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  54
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  54
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacatggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  55
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  55

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Ala Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  56
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  56
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacgccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  57
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  57

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Arg Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  58
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  58
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag agtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  59
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  59

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Leu Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  60
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  60
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ctctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  61
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  61

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Gly Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  62
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  62
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatggcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  63
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  63

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Ser 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  64
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  64
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgtc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  65
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  65

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Gly Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  66
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  66
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg ggggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  67
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  67

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Cys Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  68
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  68
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctgtatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  69
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  69

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Phe Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  70
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  70
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg tttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  71
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  71

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Gly Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  72
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  72
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatgggca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  73
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  73

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Gly Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  74
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  74
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatggt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  75
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  75

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Thr Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  76
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  76
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagaccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  77
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  77

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asn Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  78
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  78
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acaatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  79
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  79

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe His Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  80
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  80
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggctcca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccactac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatagcac     2760

aggtctagag aaatgatacc tttttttttt tttgagacag agtctcactc tgttgcccag     2820

gctgcagtgc agtggtgtga tcttggctca ctacaacctc tgcctcccgg gttcaagtaa     2880

ttctcctgcc tcaggcttct gagtagctgg gattataggt gcgcaccacc acacccggct     2940

agtttctgta tttttagtag agacggcgtt tcaccatttt ggccggcctc ctcggcctcc     3000

caaagttctg ggattacagg catgagccac tgtgcccagt caggatgtct ttaatgtagg     3060

aatcattcaa gatccctcct cagtgcccat gtctccccca cctcagggtg ctgtcaaccc     3120

tcccttggtt tccatgatca ttgctgaact cagagctttc ttctatcccc agacccacat     3180

gggagtctcc cagcacctct gactcagctt ggccaatgca gaacttggca tctgaacccc     3240

tgcctcttcc ctgaaccact cctcctcctg atttccctgc tctctctgct cagaacacta     3300

ccattcaccc catctcccag agacactctc cctcctcctc tttcaccttc atacaagcag     3360

gcccccgtcc tatcagtaca cccccctgtg atgcctctga aatatgtacc ctcctcccct     3420

ctcctactgt cattcttata cctgtgatct ctgcgtttct cttctacact gctgccagag     3480

gcctttttgc caaaagcact gctgattgtc actcttttac tttcctggtt cccctttgac     3540

ttcacacact tgacgtttac attttgtcac agttggtccc ccttgccttc acatacctga     3600

tgtttaaatt ttgtcacggt tagtctccaa acttctcaac tttgccagct ttctccaatg     3660

aaaccatcag tagagacatt gctgttcctg cccatcccag tgccagctac tccttcctgg     3720

aagccttcct ggatttcacg catcccatcc tctggccaga aatggcctcc gaactgtgca     3780

gctcctgcag caccatttgt atcatagcat atctgttatg tgtcgttgct ttctgtgtct     3840

tggtttctgc ctgctgccca cttccctaga ctggagccta ctggggcatg gtattttatt     3900

catttctgac ctccaattcc ctaagtggag attaaatgtt agaaacctga                3950


<210>  81
<211>  496
<212>  PRT
<213>  Homo Sapiens

<400>  81

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Ala Asp Phe Glu Arg Asn Val Asp Ser Gly Pro Gln Leu Thr Gln 
    450                 455                 460                 


Ser Ile Tyr Asp Thr Met Ile Ser Trp Leu Met Glu Leu Phe Ser Ala 
465                 470                 475                 480 


Ala Glu Thr Glu Pro Leu Leu Arg Glu Pro Trp Ser Pro Pro Thr Leu 
                485                 490                 495     


<210>  82
<211>  1500
<212>  DNA
<213>  Homo Sapiens

<400>  82
ggactttcca aggcctccca aagctctctg gcacccaggg aacagtgtgc gtgtcgagag       60

cttaatccgc aggagcatag ccatggttct ctggggtcca gtgctgggag ctctgctggt      120

ggtcattgct ggatacctgt gcctgccagg gatgctccga caacgcaggc catgggagcc      180

ccctctggac aagggtaccg tgccctggct tggccatgcc atggctttcc ggaagaatat      240

gtttgaattt ctgaagcgca tgaggaccaa gcatggggat gtgttcacag tgcagctagg      300

gggccagtac ttcaccttcg tcatggaccc cctctccttt ggctccatcc tcaaggacac      360

acagagaaaa ctagactttg ggcaatatgc aaaaaaactg gtgctgaagg tatttggata      420

ccgttcagtg caaggggacc atgagatgat acactcagcc agcaccaagc atctgagggg      480

ggatggcttg aaggatctta atgagaccat gctggacagc ctgtcctttg taatgctgac      540

gtccaaaggc tggagtctgg atgccagttg ctggcatgag gacagcctct ttcgcttctg      600

ctattacatc ttgttcacag ctggctacct gagcttgttc ggctacacga aggacaagga      660

gcaggacctg ctacaggcag gagagttatt catggagttc cgcaagtttg accttctttt      720

cccaaggttt gtctactccc tgctgtggcc ccgggagtgg ctagaagtgg gccgactcca      780

gcgtctcttt cacaagatgc tctccgtgag ccacagccag gagaaggagg gcatcagcaa      840

ctggctgggc aacatgcttc agtttctgag ggagcagggg gtaccctcag ctatgcagga      900

caagttcaac ttcatgatgc tctgggcctc ccaggggaac acggggccta cctctttctg      960

ggccctcttg tacctcctga agcacccaga agctattcgg gctgtgaggg aggaagctac     1020

ccaggtcctg ggtgaggcca ggctggagac caagcagtcc tttgccttca aactcggtgc     1080

cctgcaacac accccagttc tagacagcgt ggtggaggag acgctgcggc tgagggctgc     1140

acccaccctc ctcaggttgg ttcatgaaga ctataccctg aagatgtcca gtgggcagga     1200

gtatctgttc cgccatggag acatcctggc cctctttccc tacctctcag tgcacatgga     1260

ccctgacatc caccctgagc ccaccgtctt caagtacgat cgcttcctca accctaatgg     1320

cagccggaaa gtggacttct tcaagacagg caagaagatc caccactaca ccatgccctg     1380

gggttcgggc gtttccatct gccctgggag gttctttgca ctcagtgagg cagacttcga     1440

aagaaatgtt gactcgggtc ctcagttgac ccaaagtatc tatgatacca tgatctcatg     1500


<210>  83
<211>  272
<212>  PRT
<213>  Homo Sapiens

<400>  83

Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
1               5                   10                  15      


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
            20                  25                  30          


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
        35                  40                  45              


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
    50                  55                  60                  


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
65                  70                  75                  80  


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
                85                  90                  95      


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
            100                 105                 110         


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
        115                 120                 125             


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
    130                 135                 140                 


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
145                 150                 155                 160 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
                165                 170                 175     


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
            180                 185                 190         


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
        195                 200                 205             


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
    210                 215                 220                 


Glu Ala Asp Phe Glu Arg Asn Val Asp Ser Gly Pro Gln Leu Thr His 
225                 230                 235                 240 


Ser Ile Tyr Asp Thr Met Ile Ser Trp Leu Met Glu Leu Phe Ser Ala 
                245                 250                 255     


Ala Glu Thr Glu Pro Leu Leu Arg Glu Pro Trp Ser Pro Pro Thr Leu 
            260                 265                 270         


<210>  84
<211>  1573
<212>  DNA
<213>  Homo Sapiens

<400>  84
ggactttcca aggcctccca aagctctctg gcacccaggg aacagtgtgc gtgtcgagag       60

cttaatccgc aggagcatag ccatggttct ctggggtcca gtgctgggag ctctgctggt      120

ggtcattgct ggatacctgt gcctgccagg gatgctccga caacgcaggc catgggagcc      180

ccctctggac aagggtaccg tgccctggct tggccatgcc atggctttcc ggaagaatat      240

gtttgaattt ctgaagcgca tgaggaccaa gcatggggat gtgttcacag tgcagctagg      300

gggccagtac ttcaccttcg tcatggaccc cctctccttt ggctccatcc tcaaggacac      360

acagagaaaa ctagactttg ggcaatatgc aaaaaaactg gtgctgaagg tatttggata      420

ccgttcagtg caaggggacc atgagatgat acactcagcc agcaccaagc atctgagggg      480

ggatggcttg aaggatctta atgagaccat gctggacagc ctgtcctttg taatgctgac      540

gtccaaaggc tggagtctgg atgccagttg ctggcatgag gacagcctct ttcgcttctg      600

ctattacatc ttgttcacag ctggctacct gagcttgttc ggctacacga aggacaagga      660

gcaggacctg ctacaggcag gagagttatt catggagttc cgcaagtttg accttctttt      720

cccaaggttt gtctactccc tgctgtggcc ccgggagtgg ctagaagtgg gccgactcca      780

gcgtctcttt cacaagatgc tctccgtgag ccacagccag gagaaggagg gcatcagcaa      840

ctggctgggc aacatgcttc agtttctgag ggagcagggg gtaccctcag ctatgcagga      900

caagttcaac ttcatgatgc tctgggcctc ccaggggaac acggggccta cctctttctg      960

ggccctcttg tacctcctga agcacccaga agctattcgg gctgtgaggg aggaagctac     1020

ccaggtcctg ggtgaggcca ggctggagac caagcagtcc tttgccttca aactcggtgc     1080

cctgcaacac accccagttc tagacagcgt ggtggaggag acgctgcggc tgagggctgc     1140

acccaccctc ctcaggttgg ttcatgaaga ctataccctg aagatgtcca gtgggcagga     1200

gtatctgttc cgccatggag acatcctggc cctctttccc tacctctcag tgcacatgga     1260

ccctgacatc caccctgagc ccaccgtctt caagtacgat cgcttcctca accctaatgg     1320

cagccggaaa gtggacttct tcaagacagg caagaagatc caccactaca ccatgccctg     1380

gggttcgggc gtttccatct gccctgggag gttctttgca ctcagtgagg cagacttcga     1440

aagaaatgtt gactcgggtc ctccgttgac ccaaagtatc tatgatacca tgatctcatg     1500

gctgatggaa ctattcagtg ctgctgaaac agaacctctc ctgagggagc cctggagtcc     1560

tcccactctg tga                                                        1573


