                         SEQUENCE LISTING

<110>  Pfizer Inc.
       Finlay, William James Jonathan
       Fennell, Brian Joseph
       Cao, Wei
       Shih, Heather Hongrong
 
<120>  Novel Chicken Monoclonal Antibodies Against Human Phosphorylated 
       Tau and Uses Therefor

<130>  PC71717A

<140>  PCT/IB2013/to be assigned
<141>  2013-07-17

<150>  US 61/674,943
<151>  2012-07-24

<160>  71    

<170>  PatentIn version 3.5

<210>  1
<211>  758
<212>  PRT
<213>  Homo Sapiens

<400>  1

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Glu Pro Glu Ser 
        115                 120                 125             


Gly Lys Val Val Gln Glu Gly Phe Leu Arg Glu Pro Gly Pro Pro Gly 
    130                 135                 140                 


Leu Ser His Gln Leu Met Ser Gly Met Pro Gly Ala Pro Leu Leu Pro 
145                 150                 155                 160 


Glu Gly Pro Arg Glu Ala Thr Arg Gln Pro Ser Gly Thr Gly Pro Glu 
                165                 170                 175     


Asp Thr Glu Gly Gly Arg His Ala Pro Glu Leu Leu Lys His Gln Leu 
            180                 185                 190         


Leu Gly Asp Leu His Gln Glu Gly Pro Pro Leu Lys Gly Ala Gly Gly 
        195                 200                 205             


Lys Glu Arg Pro Gly Ser Lys Glu Glu Val Asp Glu Asp Arg Asp Val 
    210                 215                 220                 


Asp Glu Ser Ser Pro Gln Asp Ser Pro Pro Ser Lys Ala Ser Pro Ala 
225                 230                 235                 240 


Gln Asp Gly Arg Pro Pro Gln Thr Ala Ala Arg Glu Ala Thr Ser Ile 
                245                 250                 255     


Pro Gly Phe Pro Ala Glu Gly Ala Ile Pro Leu Pro Val Asp Phe Leu 
            260                 265                 270         


Ser Lys Val Ser Thr Glu Ile Pro Ala Ser Glu Pro Asp Gly Pro Ser 
        275                 280                 285             


Val Gly Arg Ala Lys Gly Gln Asp Ala Pro Leu Glu Phe Thr Phe His 
    290                 295                 300                 


Val Glu Ile Thr Pro Asn Val Gln Lys Glu Gln Ala His Ser Glu Glu 
305                 310                 315                 320 


His Leu Gly Arg Ala Ala Phe Pro Gly Ala Pro Gly Glu Gly Pro Glu 
                325                 330                 335     


Ala Arg Gly Pro Ser Leu Gly Glu Asp Thr Lys Glu Ala Asp Leu Pro 
            340                 345                 350         


Glu Pro Ser Glu Lys Gln Pro Ala Ala Ala Pro Arg Gly Lys Pro Val 
        355                 360                 365             


Ser Arg Val Pro Gln Leu Lys Ala Arg Met Val Ser Lys Ser Lys Asp 
    370                 375                 380                 


Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Thr Ser Thr Arg Ser Ser 
385                 390                 395                 400 


Ala Lys Thr Leu Lys Asn Arg Pro Cys Leu Ser Pro Lys His Pro Thr 
                405                 410                 415     


Pro Gly Ser Ser Asp Pro Leu Ile Gln Pro Ser Ser Pro Ala Val Cys 
            420                 425                 430         


Pro Glu Pro Pro Ser Ser Pro Lys His Val Ser Ser Val Thr Ser Arg 
        435                 440                 445             


Thr Gly Ser Ser Gly Ala Lys Glu Met Lys Leu Lys Gly Ala Asp Gly 
    450                 455                 460                 


Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys 
465                 470                 475                 480 


Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro 
                485                 490                 495     


Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser 
            500                 505                 510         


Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg 
        515                 520                 525             


Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala 
    530                 535                 540                 


Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu 
545                 550                 555                 560 


Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys 
                565                 570                 575     


Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val 
            580                 585                 590         


Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys 
        595                 600                 605             


Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln 
    610                 615                 620                 


Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly 
625                 630                 635                 640 


Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val 
                645                 650                 655     


Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly 
            660                 665                 670         


Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile 
        675                 680                 685             


Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp 
    690                 695                 700                 


His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr 
705                 710                 715                 720 


Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met 
                725                 730                 735     


Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser 
            740                 745                 750         


Leu Ala Lys Gln Gly Leu 
        755             


<210>  2
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pS396/pS404 - portion of human Tau showing phosphorylation at 
       Serine 6 and Serine 14


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  PHOSPHORYLATION

<400>  2

Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg 
1               5                   10                  15      


His Leu Cys 
            


<210>  3
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S396/S404 - portion of human tau without phosphorylation

<400>  3

Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg 
1               5                   10                  15      


His Leu Cys 
            


<210>  4
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pS396/pS404 - scrambled portion of human tau sequence with 
       phosphorylation at Serine 6 and Serine 14


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  PHOSPHORYLATION

<400>  4

Arg Ile Gly Val His Ser Pro Glu Leu Lys Val Ser Tyr Ser Pro Asp 
1               5                   10                  15      


Val Thr Cys 
            


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pS422  Phospho - portion of human Tau showing phosphorylation at 
       Serine 8


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  PHOSPHORYLATION

<400>  5

Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Cys 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S422  Non-phospho - portion of human tau without phosphorylation

<400>  6

Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Cys 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pS422  Scrambled - scrambled portion of human tau sequence with 
       phosphorylation at Serine 8


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  PHOSPHORYLATION

<400>  7

Thr Leu Asp Leu Ser Ala Gly Ser Pro Asp Met Ile Gln Val Cys 
1               5                   10                  15  


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT212/pS214 - Phospho -portion of human Tau showing 
       phosphorylation at Threonine 6 and Serine 8


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  PHOSPHORYLATION

<400>  8

Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Cys 
1               5                   10                  15      


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T212/S214  Non-phospho - portion of human tau without 
       phosphorylation

<400>  9

Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Cys 
1               5                   10                  15      


<210>  10
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT212/pS214  Scrambled - scrambled portion of human tau sequence 
       with phosphorylation at Threonine 6 and Serine 8


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  PHOSPHORYLATION

<400>  10

Thr Arg Gly Pro Ser Thr Pro Ser Pro Arg Ser Arg Thr Pro Leu Cys 
1               5                   10                  15      


<210>  11
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT231/pS235  Phospho - portion of human Tau showing 
       phosphorylation at Threonine 8 and Serine 12


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  PHOSPHORYLATION

<400>  11

Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala 
1               5                   10                  15      


Lys Cys 
        


<210>  12
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T231/S235  Non-phospho - portion of human tau without 
       phosphorylation

<400>  12

Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala 
1               5                   10                  15      


Lys Cys 
        


<210>  13
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT231/pS235  Scrambled - scrambled portion of human tau sequence 
       with phosphorylation at Threonine 8 and Serine 12


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  PHOSPHORYLATION

<400>  13

Lys Ala Val Lys Ser Lys Pro Thr Pro Ser Arg Ser Pro Ala Val Lys 
1               5                   10                  15      


Val Cys 
        


<210>  14
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT231/pS235_1 VL

<400>  14

Ala Leu Thr Gln Pro Thr Ser Val Ser Ala Asn Leu Gly Gly Ser Val 
1               5                   10                  15      


Glu Ile Thr Cys Ser Gly Ser Asp Tyr Asp Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ala Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Trp Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Thr Ser Gly Ser 
    50                  55                  60                  


Thr Ser Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gly Ala Tyr Asp Gly Ser Ala Gly Gly Gly Ile Phe Gly 
                85                  90                  95      


Ala Gly Thr Thr Leu Thr Val Leu 
            100                 


<210>  15
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT231/pS235_1 VH

<400>  15

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Gly Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Leu Ser Ser Tyr 
            20                  25                  30          


Gln Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Thr Ser Arg Gly Gly Val Thr Gly Tyr Gly Ser Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Ala Leu Asp Ser Asp Gln Cys Gly Phe Pro Glu Ala Gly 
            100                 105                 110         


Cys Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125         


<210>  16
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT231/pS235_2 VL

<400>  16

Ala Leu Thr Gln Pro Thr Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Asp Ser Ser Trp Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr Asn Asn Asn Asn 
        35                  40                  45              


Arg Pro Ser Asn Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Gly His Asp Ser Ser Tyr Ala Gly Ile Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu 
            100             


<210>  17
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT231/pS235_2 VH

<400>  17

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Gly Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Leu Ser Ser Tyr 
            20                  25                  30          


Gln Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Thr Ser Arg Gly Gly Val Thr Gly Tyr Gly Ser Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Ala Leu Asp Ser Asp Gln Cys Gly Phe Pro Glu Ala Gly 
            100                 105                 110         


Cys Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125         


<210>  18
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT212/pS214_1 VL

<400>  18

Ala Leu Thr Gln Pro Thr Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile 
        35                  40                  45              


Tyr Asp Asn Thr Asn Arg Pro Ser Asn Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Leu Ser Gly Ser Thr Ser Thr Leu Thr Ile Thr Gly Val Gln Ala 
65                  70                  75                  80  


Glu Asp Glu Ala Val Tyr Phe Cys Gly Gly Tyr Asp Ser Ser Thr Tyr 
                85                  90                  95      


Ala Gly Ile Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105                 


<210>  19
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT212/pS214_1 VH

<400>  19

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Asn Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Lys Thr Gly Arg Ser Thr Tyr Tyr Gly Ala Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Thr Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr Phe Cys 
                85                  90                  95      


Ala Lys Gly Ala Thr Gly Pro Tyr Ile Ile Asp Thr Trp Gly His Gly 
            100                 105                 110         


Thr Glu Val Ile Val Ser Ser 
        115                 


<210>  20
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT212/pS214_2 VL

<400>  20

Ala Leu Thr Gln Pro Thr Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Gly Tyr Gly Tyr Gly Trp Phe 
            20                  25                  30          


Gln Gln Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Tyr Asn 
        35                  40                  45              


Asp Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Thr Ser 
    50                  55                  60                  


Gly Ser Thr Ser Thr Leu Thr Ile Thr Gly Val Gln Val Glu Asp Glu 
65                  70                  75                  80  


Ala Val Tyr Tyr Cys Gly Ser Gly Asp Ser Ser Gly Ala Gly Ile Phe 
                85                  90                  95      


Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105 


<210>  21
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT212/pS214_2 VH

<400>  21

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Gly Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Val Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Asp Ala Ala Gly Ser Gly Thr Trp Tyr Ala Thr Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Phe Cys 
                85                  90                  95      


Ala Lys Thr Thr Pro Ser Thr Ser Gly Gly Trp Ser Val Gly Ser Ile 
            100                 105                 110         


Asp Thr Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  22
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pS396/pS404_1 VL

<400>  22

Ala Leu Thr Gln Pro Thr Ser Val Ser Ala Asn Leu Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Glu Ser Gly Asn Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ala Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Gln Asn Thr Gln 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Gly Thr Leu Thr Ile Thr Gly Val Gln Ala Asp Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Ser Gly Asp Gly Asn Phe Val Gly Ile Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu 
            100             


<210>  23
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pS396/pS404_1 VH

<400>  23

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Gly Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Ser Ser Ser Gly Thr Tyr Thr Asn Tyr Ala Pro Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Ser Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Thr Thr Gly Arg Gly Ala Gly Glu Ile Asp Ala Trp Gly His 
            100                 105                 110         


Gly Thr Glu Val Ile Val Ser Ser 
        115                 120 


<210>  24
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pS396/pS404_2 VL

<400>  24

Ala Leu Thr Gln Pro Thr Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Asp Ser Tyr Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Asp Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Gly Thr Leu Thr Ile Thr Gly Val Gln Ala Asp Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Thr Glu Asp Arg Ser Gly Thr Pro Ile Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu 
            100             


<210>  25
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pS396/pS404_2 VH

<400>  25

Asp Arg Ala Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Thr Ile Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Met Ser Ser Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Ser Ser Arg Gly Ser Ser Thr Gly Tyr Gly Ala Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Gly Lys Asp Ser Gly Gly Arg Cys Gly Gly Arg Ser Tyr Ser Gly Gly 
            100                 105                 110         


Cys Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125         


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT231/pS235_1 VL  CDR1

<400>  26

Ser Gly Ser Asp Tyr Asp Tyr Gly 
1               5               


<210>  27
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT231/pS235_1 VH  CDR1

<400>  27

Ser Tyr Gln Met Met 
1               5   


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT231/pS235_2 VL  CDR1

<400>  28

Ser Gly Asp Ser Ser Trp Tyr Gly 
1               5               


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT231/pS235_2 VH  CDR1

<400>  29

Ser Tyr Gln Met Met 
1               5   


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT212/pS214_1 VL  CDR1

<400>  30

Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr Gly 
1               5                   10              


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT212/pS214_1 VH  CDR1

<400>  31

Ser Phe Asn Met Phe 
1               5   


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT212/pS214_2 VL  CDR1

<400>  32

Ser Gly Gly Gly Ser Gly Tyr Gly Tyr Gly 
1               5                   10  


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT212/pS214_2 VH  CDR1

<400>  33

Ser Tyr Pro Met Val 
1               5   


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pS396/pS404_1 VL  CDR1

<400>  34

Ser Gly Glu Ser Gly Asn Tyr Gly 
1               5               


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pS396/pS404_1 VH  CDR1

<400>  35

Ser Tyr Gly Met Ala 
1               5   


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pS396/pS404_2 VL  CDR1

<400>  36

Ser Gly Gly Asp Ser Tyr Tyr Gly 
1               5               


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pS396/pS404_2 VH  CDR1

<400>  37

Ser Tyr Gly Met Asn 
1               5   


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT231/pS235_1 VL  CDR2

<400>  38

Trp Asn Asp Lys Arg Pro Ser 
1               5           


<210>  39
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT231/pS235_1 VH  CDR2

<400>  39

Gly Ile Thr Ser Arg Gly Gly Val Thr Gly Tyr Gly Ser Ala Val Lys 
1               5                   10                  15      


Gly 
    


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT231/pS235_2 VL  CDR2

<400>  40

Asn Asn Asn Asn Arg Pro Ser 
1               5           


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT231/pS235_2 VH  CDR2

<400>  41

Gly Ile Thr Ser Arg Gly Gly Val Thr Gly Tyr Gly Ser Ala Val Lys 
1               5                   10                  15      


Gly 
    


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT212/pS214_1 VL  CDR2

<400>  42

Asp Asn Thr Asn Arg Pro Ser 
1               5           


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT212/pS214_1 VH  CDR2

<400>  43

Gly Ile Gly Lys Thr Gly Arg Ser Thr Tyr Tyr Gly Ala Ala Val Lys 
1               5                   10                  15      


Gly 
    


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT212/pS214_2 VL  CDR2

<400>  44

Tyr Asn Asp Lys Arg Pro Ser 
1               5           


<210>  45
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT212/pS214_2 VH  CDR2

<400>  45

Asp Ile Asp Ala Ala Gly Ser Gly Thr Trp Tyr Ala Thr Ala Val Lys 
1               5                   10                  15      


Gly 
    


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pS396/pS404_1 VL  CDR2

<400>  46

Gln Asn Thr Gln Arg Pro Ser 
1               5           


<210>  47
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pS396/pS404_1 VH  CDR2

<400>  47

Gly Ile Ser Ser Ser Gly Thr Tyr Thr Asn Tyr Ala Pro Ala Val Lys 
1               5                   10                  15      


Gly 
    


<210>  48
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pS396/pS404_2 VL  CDR2

<400>  48

Asp Asn Asp Lys Arg Pro Ser 
1               5           


<210>  49
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pS396/pS404_2 VH  CDR2

<400>  49

Val Ile Ser Ser Arg Gly Ser Ser Thr Gly Tyr Gly Ala Ala Val Lys 
1               5                   10                  15      


Gly 
    


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT231/pS235_1 VL  CDR3

<400>  50

Gly Ala Tyr Asp Gly Ser Ala Gly Gly Gly Ile 
1               5                   10      


<210>  51
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT231/pS235_1 VH  CDR3

<400>  51

Pro Ala Leu Asp Ser Asp Gln Cys Gly Phe Pro Glu Ala Gly Cys Ile 
1               5                   10                  15      


Asp Ala 
        


<210>  52
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT231/pS235_2 VL  CDR3

<400>  52

Gly Gly His Asp Ser Ser Tyr Ala Gly Ile 
1               5                   10  


<210>  53
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT231/pS235_2 VH  CDR3

<400>  53

Pro Ala Leu Asp Ser Asp Gln Cys Gly Phe Pro Glu Ala Gly Cys Ile 
1               5                   10                  15      


Asp Ala 
        


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT212/pS214_1 VL  CDR3

<400>  54

Gly Gly Tyr Asp Ser Ser Thr Tyr Ala Gly Ile 
1               5                   10      


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT212/pS214_1 VH  CDR3

<400>  55

Gly Ala Thr Gly Pro Tyr Ile Ile Asp Thr 
1               5                   10  


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT212/pS214_2 VL  CDR3

<400>  56

Gly Ser Gly Asp Ser Ser Gly Ala Gly Ile 
1               5                   10  


<210>  57
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT212/pS214_2 VH  CDR3

<400>  57

Thr Thr Pro Ser Thr Ser Gly Gly Trp Ser Val Gly Ser Ile Asp Thr 
1               5                   10                  15      


<210>  58
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pS396/pS404_1 VL  CDR3

<400>  58

Gly Ser Gly Asp Gly Asn Phe Val Gly Ile 
1               5                   10  


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pS396/pS404_1 VH  CDR3

<400>  59

Thr Thr Gly Arg Gly Ala Gly Glu Ile Asp Ala 
1               5                   10      


<210>  60
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pS396/pS404_2 VL  CDR3

<400>  60

Gly Thr Glu Asp Arg Ser Gly Thr Pro Ile 
1               5                   10  


<210>  61
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pS396/pS404_2 VH  CDR3

<400>  61

Asp Ser Gly Gly Arg Cys Gly Gly Arg Ser Tyr Ser Gly Gly Cys Ile 
1               5                   10                  15      


Asp Ala 
        


<210>  62
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germline VL

<400>  62

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Asp Ser Ser Tyr Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ala Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Asp Asn Thr Asn 
        35                  40                  45              


Arg Pro Ser Asn Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Thr Gly Val Arg Ala Asp Asp Asn Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Ala Ser Thr Asp Ser Ser Thr Ala Gly Ile Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu 
            100             


<210>  63
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germline VH

<400>  63

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Arg 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asn Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asp Asn Thr Gly Arg Tyr Thr Gly Tyr Gly Ser Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Ala Gly Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germline VL CDR1

<400>  64

Ser Gly Asp Ser Ser Tyr Tyr Gly 
1               5               


<210>  65
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germline VH CDR1

<400>  65

Ser Tyr Asn Met Gly 
1               5   


<210>  66
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germline VL CDR2

<400>  66

Asp Asn Thr Asn Arg Pro Ser 
1               5           


<210>  67
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germline VH CDR2

<400>  67

Gly Ile Asp Asn Thr Gly Arg Tyr Thr Gly Tyr Gly Ser Ala Val Lys 
1               5                   10                  15      


Gly 
    


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germline VL CDR3

<400>  68

Ala Ser Thr Asp Ser Ser Thr Ala Gly Ile 
1               5                   10  


<210>  69
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germline VH CDR3

<400>  69

Ala Ala Gly Ile Asp Ala 
1               5       


<210>  70
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT231/pS235 Heavy Chain

<400>  70

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Gly Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Leu Ser Ser Tyr 
            20                  25                  30          


Gln Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Thr Ser Arg Gly Gly Val Thr Gly Tyr Gly Ser Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Ala Leu Asp Ser Asp Gln Cys Gly Phe Pro Glu Ala Gly 
            100                 105                 110         


Cys Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  71
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pT231/pS235 Light Chain

<400>  71

Ala Leu Thr Gln Pro Thr Ser Val Ser Ala Asn Leu Gly Gly Ser Val 
1               5                   10                  15      


Glu Ile Thr Cys Ser Gly Ser Asp Tyr Asp Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ala Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Trp Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Thr Ser Gly Ser 
    50                  55                  60                  


Thr Ser Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gly Ala Tyr Asp Gly Ser Ala Gly Gly Gly Ile Phe Gly 
                85                  90                  95      


Ala Gly Thr Thr Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser 
            100                 105                 110         


Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala 
        115                 120                 125             


Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val 
    130                 135                 140                 


Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr 
145                 150                 155                 160 


Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu 
                165                 170                 175     


Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln 
            180                 185                 190         


Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu 
        195                 200                 205             


Cys 
    


