
SEQUENCE LISTING

<110> LEE, Gregory

<120> HUMANIZED FORMS OF MONOCLONAL ANTIBODIES
      TO HUMAN GnRH RECEPTOR

<130> 616342000400

<140> 13/797,653          
<141> 2013-03-12  

<150> 61/676,763          
<151> 2012-07-27  

<160> 22

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> CHAIN          
<222> (1)...(5)
<223> CDR1 region of heavy chain of hGHR106

<400> 1
Arg Tyr Ser Val His
 1               5  


<210> 2
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> CHAIN          
<222> (1)...(17)
<223> CDR2 region of heavy chain of hGHR106

<400> 2
Met Ile Trp Gly Gly Gly Ser Thr Asp Tyr Asn Ser Pro Ser Leu Lys
 1               5                  10                  15      
Ser
    


<210> 3
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> CHAIN          
<222> (1)...(16)
<223> CDR2 region of heavy chain of hGHR106

<400> 3
Met Ile Trp Gly Gly Gly Ser Thr Asp Tyr Asn Ser Ser Leu Gln Ser
 1               5                  10                  15      


<210> 4
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> CHAIN          
<222> (1)...(15)
<223> CDR2 region of heavy chain of hGHR106

<400> 4
Met Ile Trp Gly Gly Ser Thr Asp Tyr Asn Ser Ser Leu Gln Ser
 1               5                  10                  15  


<210> 5
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> CHAIN          
<222> (1)...(10)
<223> CDR3 region of heavy chain of hGHR106

<400> 5
Gly Asn Asp Gly Tyr Tyr Ser Phe Ala Tyr
 1               5                  10  


<210> 6
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> CHAIN          
<222> (1)...(17)
<223> CDR1 region of light chain of hGHR106

<400> 6
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu
 1               5                  10                  15      
Ala
    


<210> 7
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> CHAIN          
<222> (1)...(7)
<223> CDR2 region of light chain of hGHR106

<400> 7
Trp Ala Ser Thr Arg Glu Ser
 1               5          


<210> 8
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> CHAIN          
<222> (1)...(80)
<223> CDR3 region of light chain of hGHR106

<400> 8
Lys Gln Ser Tyr Asn Leu Tyr Thr
 1               5              


<210> 9
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> CHAIN          
<222> (1)...(117)
<223> heavy chain of hGHR106_H65

<400> 9
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Val Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr
            20                  25                  30          
Ser Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Met Ile Trp Gly Gly Ser Thr Asp Tyr Asn Ser Ser Leu Gln Ser
    50                  55                  60                  
Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys
65                  70                  75                  80  
Met Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala Arg
                85                  90                  95      
Gly Asn Asp Gly Tyr Tyr Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110         
Val Thr Val Ser Ser
        115         


<210> 10
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> CHAIN          
<222> (1)...(118)
<223> heavy chain of hGHR106_H66

<400> 10
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Val Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr
            20                  25                  30          
Ser Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Met Ile Trp Gly Gly Gly Ser Thr Asp Tyr Asn Ser Ser Leu Gln
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65                  70                  75                  80  
Lys Met Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala
                85                  90                  95      
Arg Gly Asn Asp Gly Tyr Tyr Ser Phe Ala Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 11
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> CHAIN          
<222> (1)...(118)
<223> heavy chain of hGHR106_H64

<400> 11
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr
            20                  25                  30          
Ser Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Met Ile Trp Gly Gly Gly Ser Thr Asp Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65                  70                  75                  80  
Lys Met Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala
                85                  90                  95      
Arg Gly Asn Asp Gly Tyr Tyr Ser Phe Ala Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 12
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> CHAIN          
<222> (1)...(118)
<223> heavy chain of hGHR106_Murine

<400> 12
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr
            20                  25                  30          
Ser Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Met Ile Trp Gly Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala
                85                  90                  95      
Arg Gly Asn Asp Gly Tyr Tyr Ser Phe Ala Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 13
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> CHAIN          
<222> (1)...(112)
<223> light chain of hGHR106_L41

<400> 13
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
            20                  25                  30          
Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln
                85                  90                  95      
Ser Tyr Asn Leu Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 14
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> CHAIN          
<222> (1)...(112)
<223> light chain of hGHR106_L42

<400> 14
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
            20                  25                  30          
Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln
                85                  90                  95      
Ser Tyr Asn Leu Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 15
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> CHAIN          
<222> (1)...(112)
<223> light chain of hGHR106_L43

<400> 15
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
            20                  25                  30          
Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln
                85                  90                  95      
Ser Tyr Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 16
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> CHAIN          
<222> (1)...(112)
<223> light chain of hGHR106_Murine

<400> 16
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
            20                  25                  30          
Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln
                85                  90                  95      
Ser Tyr Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 17
<211> 1407
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> misc_feature   
<222> (1)...(1407)
<223> p7164 encoding hGHR106_H64

<400> 17
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga 60
caggttcagt tgcaagagtc tggtcccggc ctggttaaac cctctgagac tttgagcttg 120
acatgcaccg taagcggctt ctctctgagc cggtactctg tacactggat tcgacagcct 180
cctggcaagg gcctggaatg gattggcatg atctggggcg gcggaagtac agattataac 240
ccttccttga agagccgcgt caccatctct aaggacaaca gcaagtccca ggtcttcctg 300
aagatgtcaa gcgtcaccgc tgccgacacc gccatgtact actgtgcacg ggggaatgac 360
ggatactaca gtttcgcata ttggggccag ggaacactgg ttacagtgtc tagtgctagc 420
accaagggcc ccagcgtgtt ccctctggcc cccagcagca agagcaccag cggcggaacc 480
gccgccctgg gctgcctggt gaaggactac ttccccgagc ccgtgaccgt gtcctggaac 540
agcggcgctc tgaccagcgg agtgcacacc ttccctgccg tgctgcagag cagcggcctg 600
tactccctga gcagcgtggt gaccgtgccc agcagcagcc tgggcaccca gacctacatc 660
tgcaacgtga accacaagcc ctccaacacc aaggtggaca agaaggtgga gcctaagagc 720
tgcgacaaga cccacacctg ccctccctgc cccgcccccg agctgctggg cggacccagc 780
gtgttcctgt tccctcccaa gcccaaggac accctgatga tcagccgcac ccccgaggtg 840
acctgcgtgg tggtggacgt gagccacgag gaccccgagg tgaagttcaa ctggtacgtg 900
gacggcgtgg aggtgcacaa cgccaagacc aagcctcggg aggagcagta caactccacc 960
taccgcgtgg tgagcgtgct gaccgtgctg caccaggact ggctgaacgg caaggagtac 1020
aagtgcaagg tgagcaacaa ggccctgccc gctcccatcg agaagaccat cagcaaggcc 1080
aagggccagc cccgggagcc tcaggtgtac accctgcccc ccagccgcga cgagctgacc 1140
aagaaccagg tgagcctgac ctgcctggtg aagggcttct acccctccga catcgccgtg 1200
gagtgggaga gcaacggcca gcctgagaac aactacaaga ccacccctcc cgtgctggac 1260
agcgacggca gcttcttcct gtacagcaag ctgaccgtgg acaagtcccg gtggcagcag 1320
ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaag 1380
agcctgagcc tgagccccgg aaagtaa                                     1407

<210> 18
<211> 1407
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> misc_feature   
<222> (1)...(1407)
<223> p7165 encoding hGHR106_H65

<400> 18
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga 60
caggttcagt tgcaagagtc tggtcccggc ctggttaaac cctctgagac tttgagcttg 120
gtctgcaccg taagcggctt ctctctgagc cggtactctg tacactggat tcgacagcct 180
cctggcaagg gcctggaatg gattggcatg atctggggcg gcggaagtac agattataac 240
agctccttgc agagccgcgt caccatctct aaggacaaca gcaagtccca ggtcttcctg 300
aagatgtcaa gcgtcaccgc tgccgacacc gccatgtact actgtgcacg ggggaatgac 360
ggatactaca gtttcgcata ttggggccag ggaacactgg ttacagtgtc tagtgctagc 420
accaagggcc ccagcgtgtt ccctctggcc cccagcagca agagcaccag cggcggaacc 480
gccgccctgg gctgcctggt gaaggactac ttccccgagc ccgtgaccgt gtcctggaac 540
agcggcgctc tgaccagcgg agtgcacacc ttccctgccg tgctgcagag cagcggcctg 600
tactccctga gcagcgtggt gaccgtgccc agcagcagcc tgggcaccca gacctacatc 660
tgcaacgtga accacaagcc ctccaacacc aaggtggaca agaaggtgga gcctaagagc 720
tgcgacaaga cccacacctg ccctccctgc cccgcccccg agctgctggg cggacccagc 780
gtgttcctgt tccctcccaa gcccaaggac accctgatga tcagccgcac ccccgaggtg 840
acctgcgtgg tggtggacgt gagccacgag gaccccgagg tgaagttcaa ctggtacgtg 900
gacggcgtgg aggtgcacaa cgccaagacc aagcctcggg aggagcagta caactccacc 960
taccgcgtgg tgagcgtgct gaccgtgctg caccaggact ggctgaacgg caaggagtac 1020
aagtgcaagg tgagcaacaa ggccctgccc gctcccatcg agaagaccat cagcaaggcc 1080
aagggccagc cccgggagcc tcaggtgtac accctgcccc ccagccgcga cgagctgacc 1140
aagaaccagg tgagcctgac ctgcctggtg aagggcttct acccctccga catcgccgtg 1200
gagtgggaga gcaacggcca gcctgagaac aactacaaga ccacccctcc cgtgctggac 1260
agcgacggca gcttcttcct gtacagcaag ctgaccgtgg acaagtcccg gtggcagcag 1320
ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaag 1380
agcctgagcc tgagccccgg aaagtaa                                     1407

<210> 19
<211> 1407
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> misc_feature   
<222> (1)...(1407)
<223> p7166 encoding hGHR106_H66

<400> 19
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga 60
caggttcagt tgaaggagtc tggtcccggc ctggttaaac cctctgagac tttgagcttg 120
gtctgcaccg taagcggctt ctctctgagc cggtactctg tacactggat tcgacagcct 180
cctggcaagg gcctggaatg gattggcatg atctggggcg gcggaagtac agattataac 240
agctccttgc agagccgcgt caccatctct aaggacaaca gcaagtccca ggtcttcctg 300
aagatgtcaa gcgtcaccgc tgccgacacc gccatgtact actgtgcacg ggggaatgac 360
ggatactaca gtttcgcata ttggggccag ggaacactgg ttacagtgtc tagtgctagc 420
accaagggcc ccagcgtgtt ccctctggcc cccagcagca agagcaccag cggcggaacc 480
gccgccctgg gctgcctggt gaaggactac ttccccgagc ccgtgaccgt gtcctggaac 540
agcggcgctc tgaccagcgg agtgcacacc ttccctgccg tgctgcagag cagcggcctg 600
tactccctga gcagcgtggt gaccgtgccc agcagcagcc tgggcaccca gacctacatc 660
tgcaacgtga accacaagcc ctccaacacc aaggtggaca agaaggtgga gcctaagagc 720
tgcgacaaga cccacacctg ccctccctgc cccgcccccg agctgctggg cggacccagc 780
gtgttcctgt tccctcccaa gcccaaggac accctgatga tcagccgcac ccccgaggtg 840
acctgcgtgg tggtggacgt gagccacgag gaccccgagg tgaagttcaa ctggtacgtg 900
gacggcgtgg aggtgcacaa cgccaagacc aagcctcggg aggagcagta caactccacc 960
taccgcgtgg tgagcgtgct gaccgtgctg caccaggact ggctgaacgg caaggagtac 1020
aagtgcaagg tgagcaacaa ggccctgccc gctcccatcg agaagaccat cagcaaggcc 1080
aagggccagc cccgggagcc tcaggtgtac accctgcccc ccagccgcga cgagctgacc 1140
aagaaccagg tgagcctgac ctgcctggtg aagggcttct acccctccga catcgccgtg 1200
gagtgggaga gcaacggcca gcctgagaac aactacaaga ccacccctcc cgtgctggac 1260
agcgacggca gcttcttcct gtacagcaag ctgaccgtgg acaagtcccg gtggcagcag 1320
ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaag 1380
agcctgagcc tgagccccgg aaagtaa                                     1407

<210> 20
<211> 720
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> misc_feature   
<222> (1)...(720)
<223> pCD3_L0041 encoding hGHR106_L41

<400> 20
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga 60
gatatcgtaa tgactcagtc ccccgatagc ctcgctgtgt cattgggtga acgggcaact 120
attaactgta agtcatcaca aagcctcctt aattctagga ccaggaaaaa ctacctggca 180
tggtatcaac agaagccagg acagccacca aagctgctga tctactgggc ttctacaaga 240
gagagtggag tgccagaccg cttctccggc tccgggagcg gcactgattt taccctcact 300
atcagctccc ttcaggcaga ggatgtggcc gtgtactatt gcaagcagag ctacaacctc 360
tacaccttcg gccaggggac taaactggaa attaagcgga ccgtggccgc ccccagcgtg 420
ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg 480
ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag 540
agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg 600
agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag 660
gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa 720


<210> 21
<211> 720
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> misc_feature   
<222> (1)...(720)
<223> pCD3_L0042 encoding hGHR106_L42

<400> 21
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga 60
gatatcgtaa tgactcagtc ccccgatagc ctcgctgtgt cattgggtga acgggcaact 120
attaactgta agtcatcaca aagcctcctt aattctagga ccaggaaaaa ctacctggca 180
tggtatcaac agaagccagg acagtcacca aagctgctga tctactgggc ttctacaaga 240
gagagtggag tgccagaccg cttctccggc tccgggagcg gcactgattt taccctcact 300
atcagctccc ttcaggcaga ggatgtggcc gtgtactatt gcaagcagag ctacaacctc 360
tacaccttcg gccaggggac taaactggaa attaagcgga ccgtggccgc ccccagcgtg 420
ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg 480
ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag 540
agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg 600
agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag 660
gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa 720


<210> 22
<211> 720
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> misc_feature   
<222> (1)...(720)
<223> pCD3_L0043 encoding hGHR106_L43

<400> 22
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga 60
gatatcgtaa tgactcagtc ccccgatagc ctcgctgtgt cattgggtga acgggcaact 120
attaactgta agtcatcaca aagcctcctt aattctagga ccaggaaaaa ctacctggca 180
tggtatcaac agaagccagg acagccacca aagctgctga tctactgggc ttctacaaga 240
gagagtggag tgccagaccg cttctccggc tccgggagcg gcactgattt taccctcact 300
atcagctccc ttcaggcaga ggatgtggcc gtgtactatt gcaagcagag ctacaacctc 360
tacaccttcg gcggagggac taaactggaa attaagcgga ccgtggccgc ccccagcgtg 420
ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg 480
ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag 540
agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg 600
agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag 660
gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa 720



