                         LISTADO DE SECUENCIAS

<110>  Universidad de Castilla La Mancha
 
<120>  Variantes de la protena de fusin sensible al calcio tdTomato-aequorina

<130>  PCT1874.23

<150>  ES P201231220
<151>  2012-07-27

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  1428
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  secuencia de nucletidos tdTomato

<400>  1
atggtgagca agggcgagga ggtcatcaaa gagttcatgc gcttcaaggt gcgcatggag       60

ggctccatga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag      120

ggcacccaga ccgccaagct gaaggtgacc aagggcggcc ccctgccctt cgcctgggac      180

atcctgtccc cccagttcat gtacggctcc aaggcgtacg tgaagcaccc cgccgacatc      240

cccgattaca agaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc      300

gaggacggcg gtctggtgac cgtgacccag gactcctccc tgcaggacgg cacgctgatc      360

tacaaggtga agatgcgcgg caccaacttc ccccccgacg gccccgtaat gcagaagaag      420

accatgggct gggaggcctc caccgagcgc ctgtaccccc gcgacggcgt gctgaagggc      480

gagatccacc aggccctgaa gctgaaggac ggcggccact acctggtgga gttcaagacc      540

atctacatgg ccaagaagcc cgtgcaactg cccggctact actacgtgga caccaagctg      600

gacatcacct cccacaacga ggactacacc atcgtggaac agtacgagcg ctccgagggc      660

cgccaccacc tgttcctggg gcatggcacc ggcagcaccg gcagcggcag ctccggcacc      720

gcctcctccg aggacaacaa catggccgtc atcaaagagt tcatgcgctt caaggtgcgc      780

atggagggct ccatgaacgg ccacgagttc gagatcgagg gcgagggcga gggccgcccc      840

tacgagggca cccagaccgc caagctgaag gtgaccaagg gcggccccct gcccttcgcc      900

tgggacatcc tgtcccccca gttcatgtac ggctccaagg cgtacgtgaa gcaccccgcc      960

gacatccccg attacaagaa gctgtccttc cccgagggct tcaagtggga gcgcgtgatg     1020

aacttcgagg acggcggtct ggtgaccgtg acccaggact cctccctgca ggacggcacg     1080

ctgatctaca aggtgaagat gcgcggcacc aacttccccc ccgacggccc cgtaatgcag     1140

aagaagacca tgggctggga ggcctccacc gagcgcctgt acccccgcga cggcgtgctg     1200

aagggcgaga tccaccaggc cctgaagctg aaggacggcg gccactacct ggtggagttc     1260

aagaccatct acatggccaa gaagcccgtg caactgcccg gctactacta cgtggacacc     1320

aagctggaca tcacctccca caacgaggac tacaccatcg tggaacagta cgagcgctcc     1380

gagggccgcc accacctgtt cctgtacggc atggacgagc tgtacaag                  1428


<210>  2
<211>  476
<212>  PRT
<213>  Secuencia Artificial 

<220>
<223>  secuencia de aminocidos tdTomato

<400>  2

Met Val Ser Lys Gly Glu Glu Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      


Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              


Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  


Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile 
65                  70                  75                  80  


Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      


Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln Asp Ser 
            100                 105                 110         


Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg Gly Thr 
        115                 120                 125             


Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 


Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 


Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu Val 
                165                 170                 175     


Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly 
            180                 185                 190         


Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             


Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His His Leu 
    210                 215                 220                 


Phe Leu Gly His Gly Thr Gly Ser Thr Gly Ser Gly Ser Ser Gly Thr 
225                 230                 235                 240 


Ala Ser Ser Glu Asp Asn Asn Met Ala Val Ile Lys Glu Phe Met Arg 
                245                 250                 255     


Phe Lys Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile 
            260                 265                 270         


Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys 
        275                 280                 285             


Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu 
    290                 295                 300                 


Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala 
305                 310                 315                 320 


Asp Ile Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp 
                325                 330                 335     


Glu Arg Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln 
            340                 345                 350         


Asp Ser Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg 
        355                 360                 365             


Gly Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met 
    370                 375                 380                 


Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu 
385                 390                 395                 400 


Lys Gly Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr 
                405                 410                 415     


Leu Val Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu 
            420                 425                 430         


Pro Gly Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn 
        435                 440                 445             


Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His 
    450                 455                 460                 


His Leu Phe Leu Tyr Gly Met Asp Glu Leu Tyr Lys
465		    470			475                    


<210>  3
<211>  567
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  secuencia de nucletidos ApoAequorina

<400>  3
gtcaaactta catcagactt cgacaaccca agatggattg gacgacacaa gcatatgttc       60

aatttccttg atgtcaacca caatggaaaa atctctcttg acgagatggt ctacaaggca      120

tctgatattg tcatcaataa ccttggagca acacctgagc aagccaaacg acacaaagat      180

gctgtggaag ccttcttcgg aggagctgga atgaaatatg gtgtggaaac tgattggcct      240

gcatatattg aaggatggaa aaaattggct actgatgaat tggagaaata cgccaaaaac      300

gaaccaaccc tcatccgcat ctggggtgat gctttgtttg atatcgttga caaagatcaa      360

aatggagcta ttacactgga tgaatggaaa gcatacacca aagctgctgg tatcatccaa      420

tcatcagaag attgcgagga aacattcaga gtgtgcgata ttgatgaaag tggacaactc      480

gatgttgatg agatgacaag acagcatctg ggattttggt acaccatgga tcctgcttgc      540

gaaaagctct acggtggagc tgtcccc                                          567


<210>  4
<211>  189
<212>  PRT
<213>  Secuencia Artificial 

<220>
<223>  secuencia de aminocidos ApoAequorina

<400>  4

Val Lys Leu Thr Ser Asp Phe Asp Asn Pro Arg Trp Ile Gly Arg His 
1               5                   10                  15      


Lys His Met Phe Asn Phe Leu Asp Val Asn His Asn Gly Lys Ile Ser 
            20                  25                  30          


Leu Asp Glu Met Val Tyr Lys Ala Ser Asp Ile Val Ile Asn Asn Leu 
        35                  40                  45              


Gly Ala Thr Pro Glu Gln Ala Lys Arg His Lys Asp Ala Val Glu Ala 
    50                  55                  60                  


Phe Phe Gly Gly Ala Gly Met Lys Tyr Gly Val Glu Thr Asp Trp Pro 
65                  70                  75                  80  


Ala Tyr Ile Glu Gly Trp Lys Lys Leu Ala Thr Asp Glu Leu Glu Lys 
                85                  90                  95      


Tyr Ala Lys Asn Glu Pro Thr Leu Ile Arg Ile Trp Gly Asp Ala Leu 
            100                 105                 110         


Phe Asp Ile Val Asp Lys Asp Gln Asn Gly Ala Ile Thr Leu Asp Glu 
        115                 120                 125             


Trp Lys Ala Tyr Thr Lys Ala Ala Gly Ile Ile Gln Ser Ser Glu Asp 
    130                 135                 140                 


Cys Glu Glu Thr Phe Arg Val Cys Asp Ile Asp Glu Ser Gly Gln Leu 
145                 150                 155                 160 


Asp Val Asp Glu Met Thr Arg Gln His Leu Gly Phe Trp Tyr Thr Met 
                165                 170                 175     


Asp Pro Ala Cys Glu Lys Leu Tyr Gly Gly Ala Val Pro 
            180                 185                 


<210>  5
<211>  2124
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  secuencia de nucletidos b12

<400>  5
atggtgagca agggcgagga ggtcatcaaa gagttcatgc gcttcaaggt gcgcatggag       60

ggctccatga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag      120

ggcacccaga ccgccaagct gaaggtgacc aagggcggcc ccctgccctt cgcctgggac      180

atcctgtccc cccagttcat gtacggctcc aaggcgtacg tgaagcaccc cgccgacatc      240

cccgattaca agaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc      300

gaggacggcg gtctggtgac cgtgacccag gactcctccc tgcaggacgg cacgctgatc      360

tacaaggtga agatgcgcgg caccaacttc ccccccgacg gccccgtaat gcagaagaag      420

accatgggct gggaggcctc caccgagcgc ctgtaccccc gcgacggcgt gctgaagggc      480

gagatccacc aggccctgaa gctgaaggac ggcggccact acctggtgga gttcaagacc      540

atctacatgg ccaagaagcc cgtgcaactg cccggctact actacgtgga caccaagctg      600

gacatcacct cccacaacga ggactacacc atcgtggaac agtacgagcg ctccgagggc      660

cgccaccacc tgttcctggg gcatggcacc ggcagcaccg gcagcggcag ctccggcacc      720

gcctcctccg aggacaacaa catggccgtc atcaaagagt tcatgcgctt caaggtgcgc      780

atggagggct ccatgaacgg ccacgagttc gagatcgagg gcgagggcga gggccgcccc      840

tacgagggca cccagaccgc caagctgaag gtgaccaagg gcggccccct gcccttcgcc      900

tgggacatcc tgtcccccca gttcatgtac ggctccaagg cgtacgtgaa gcaccccgcc      960

gacatccccg attacaagaa gctgtccttc cccgagggct tcaagtggga gcgcgtgatg     1020

aacttcgagg acggcggtct ggtgaccgtg acccaggact cctccctgca ggacggcacg     1080

ctgatctaca aggtgaagat gcgcggcacc aacttccccc ccgacggccc cgtaatgcag     1140

aagaagacca tgggctggga ggcctccacc gagcgcctgt acccccgcga cggcgtgctg     1200

aagggcgaga tccaccaggc cctgaagctg aaggacggcg gccactacct ggtggagttc     1260

aagaccatct acatggccaa gaagcccgtg caactgcccg gctactacta cgtggacacc     1320

aagctggaca tcacctccca caacgaggac tacaccatcg tggaacagta cgagcgctcc     1380

gagggccgcc accacctgtt cctgtacggc atggacgagc tgtacaaggg taccgagctg     1440

tacaagtccg gcgggagcgg atccggcggc cagtccggtg gcagtggaag tggtcaaagt     1500

ggttccggta gtggaggcca gagtggtagt ggaagtggcc aatccggact cagatctgtc     1560

aaacttacat cagacttcga caacccaaga tggattggac gacacaagca tatgttcaat     1620

ttccttgatg tcaaccacaa tggaaaaatc tctcttgacg agatggtcta caaggcatct     1680

gatattgtca tcaataacct tggagcaaca cctgagcaag ccaaacgaca caaagatgct     1740

gtggaagcct tcttcggagg agctggaatg aaatatggtg tggaaactga ttggcctgca     1800

tatattgaag gatggaaaaa attggctact gatgaattgg agaaatacgc caaaaacgaa     1860

ccaaccctca tccgcatctg gggtgatgct ttgtttgata tcgttgacaa agatcaaaat     1920

ggagctatta cactggatga atggaaagca tacaccaaag ctgctggtat catccaatca     1980

tcagaagatt gcgaggaaac attcagagtg tgcgatattg atgaaagtgg acaactcgat     2040

gttgatgaga tgacaagaca gcatctggga ttttggtaca ccatggatcc tgcttgcgaa     2100

aagctctacg gtggagctgt cccc                                            2124


<210>  6
<211>  708
<212>  PRT
<213>  Secuencia Artificial 

<220>
<223>  secuencia de aminocidos b12

<400>  6

Met Val Ser Lys Gly Glu Glu Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      


Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              


Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  


Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile 
65                  70                  75                  80  


Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      


Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln Asp Ser 
            100                 105                 110         


Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg Gly Thr 
        115                 120                 125             


Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 


Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 


Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu Val 
                165                 170                 175     


Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly 
            180                 185                 190         


Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             


Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His His Leu 
    210                 215                 220                 


Phe Leu Gly His Gly Thr Gly Ser Thr Gly Ser Gly Ser Ser Gly Thr 
225                 230                 235                 240 


Ala Ser Ser Glu Asp Asn Asn Met Ala Val Ile Lys Glu Phe Met Arg 
                245                 250                 255     


Phe Lys Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile 
            260                 265                 270         


Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys 
        275                 280                 285             


Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu 
    290                 295                 300                 


Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala 
305                 310                 315                 320 


Asp Ile Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp 
                325                 330                 335     


Glu Arg Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln 
            340                 345                 350         


Asp Ser Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg 
        355                 360                 365             


Gly Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met 
    370                 375                 380                 


Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu 
385                 390                 395                 400 


Lys Gly Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr 
                405                 410                 415     


Leu Val Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu 
            420                 425                 430         


Pro Gly Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn 
        435                 440                 445             


Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His 
    450                 455                 460                 


His Leu Phe Leu Tyr Gly Met Asp Glu Leu Tyr Lys Gly Thr Glu Leu 
465                 470                 475                 480 


Tyr Lys Ser Gly Gly Ser Gly Ser Gly Gly Gln Ser Gly Gly Ser Gly 
                485                 490                 495     


Ser Gly Gln Ser Gly Ser Gly Ser Gly Gly Gln Ser Gly Ser Gly Ser 
            500                 505                 510         


Gly Gln Ser Gly Leu Arg Ser Val Lys Leu Thr Ser Asp Phe Asp Asn 
        515                 520                 525             


Pro Arg Trp Ile Gly Arg His Lys His Met Phe Asn Phe Leu Asp Val 
    530                 535                 540                 


Asn His Asn Gly Lys Ile Ser Leu Asp Glu Met Val Tyr Lys Ala Ser 
545                 550                 555                 560 


Asp Ile Val Ile Asn Asn Leu Gly Ala Thr Pro Glu Gln Ala Lys Arg 
                565                 570                 575     


His Lys Asp Ala Val Glu Ala Phe Phe Gly Gly Ala Gly Met Lys Tyr 
            580                 585                 590         


Gly Val Glu Thr Asp Trp Pro Ala Tyr Ile Glu Gly Trp Lys Lys Leu 
        595                 600                 605             


Ala Thr Asp Glu Leu Glu Lys Tyr Ala Lys Asn Glu Pro Thr Leu Ile 
    610                 615                 620                 


Arg Ile Trp Gly Asp Ala Leu Phe Asp Ile Val Asp Lys Asp Gln Asn 
625                 630                 635                 640 


Gly Ala Ile Thr Leu Asp Glu Trp Lys Ala Tyr Thr Lys Ala Ala Gly 
                645                 650                 655     


Ile Ile Gln Ser Ser Glu Asp Cys Glu Glu Thr Phe Arg Val Cys Asp 
            660                 665                 670         


Ile Asp Glu Ser Gly Gln Leu Asp Val Asp Glu Met Thr Arg Gln His 
        675                 680                 685             


Leu Gly Phe Trp Tyr Thr Met Asp Pro Ala Cys Glu Lys Leu Tyr Gly 
    690                 695                 700                 


Gly Ala Val Pro 
705                 


<210>  7
<211>  2094
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  secuencia de nucletidos a1

<400>  7
atggtgagca agggcgagga ggtcatcaaa gagttcatgc gcttcaaggt gcgcatggag       60

ggctccatga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag      120

ggcacccaga ccgccaagct gaaggtgacc aagggcggcc ccctgccctt cgcctgggac      180

atcctgtccc cccagttcat gtacggctcc aaggcgtacg tgaagcaccc cgccgacatc      240

cccgattaca agaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc      300

gaggacggcg gtctggtgac cgtgacccag gactcctccc tgcaggacgg cacgctgatc      360

tacaaggtga agatgcgcgg caccaacttc ccccccgacg gccccgtaat gcagaagaag      420

accatgggct gggaggcctc caccgagcgc ctgtaccccc gcgacggcgt gctgaagggc      480

gagatccacc aggccctgaa gctgaaggac ggcggccact acctggtgga gttcaagacc      540

atctacatgg ccaagaagcc cgtgcaactg cccggctact actacgtgga caccaagctg      600

gacatcacct cccacaacga ggactacacc atcgtggaac agtacgagcg ctccgagggc      660

cgccaccacc tgttcctggg gcatggcacc ggcagcaccg gcagcggcag ctccggcacc      720

gcctcctccg aggacaacaa catggccgtc atcaaagagt tcatgcgctt caaggtgcgc      780

atggagggct ccatgaacgg ccacgagttc gagatcgagg gcgagggcga gggccgcccc      840

tacgagggca cccagaccgc caagctgaag gtgaccaagg gcggccccct gcccttcgcc      900

tgggacatcc tgtcccccca gttcatgtac ggctccaagg cgtacgtgaa gcaccccgcc      960

gacatccccg attacaagaa gctgtccttc cccgagggct tcaagtggga gcgcgtgatg     1020

aacttcgagg acggcggtct ggtgaccgtg acccaggact cctccctgca ggacggcacg     1080

ctgatctaca aggtgaagat gcgcggcacc aacttccccc ccgacggccc cgtaatgcag     1140

aagaagacca tgggctggga ggcctccacc gagcgcctgt acccccgcga cggcgtgctg     1200

aagggcgaga tccaccaggc cctgaagctg aaggacggcg gccactacct ggtggagttc     1260

aagaccatct acatggccaa gaagcccgtg caactgcccg gctactacta cgtggacacc     1320

aagctggaca tcacctccca caacgaggac tacaccatcg tggaacagta cgagcgctcc     1380

gagggccgcc accacctgtt cctgtacggc atggacgagc tgtacaaggg taccgagctg     1440

tacaagtccg gcgggagcgg atccggcggc cagtccggta gtggaggcca gagtggtagt     1500

ggaagtggcc aatccggact cagatctgtc aaacttacat cagacttcga caacccaaga     1560

tggattggac gacacaagca tatgttcaat ttccttgatg tcaaccacaa tggaaaaatc     1620

tctcttgacg agatggtcta caaggcatct gatattgtca tcaataacct tggagcaaca     1680

cctgagcaag ccaaacgaca caaagatgct gtggaagcct tcttcggagg agctggaatg     1740

aaatatggtg tggaaactga ttggcctgca tatattgaag gatggaaaaa attggctact     1800

gatgaattgg agaaatacgc caaaaacgaa ccaaccctca tccgcatctg gggtgatgct     1860

ttgtttgata tcgttgacaa agatcaaaat ggagctatta cactggatga atggaaagca     1920

tacaccaaag ctgctggtat catccaatca tcagaagatt gcgaggaaac attcagagtg     1980

tgcgatattg atgaaagtgg acaactcgat gttgatgaga tgacaagaca gcatctggga     2040

ttttggtaca ccatggatcc tgcttgcgaa aagctctacg gtggagctgt cccc           2094


<210>  8
<211>  698
<212>  PRT
<213>  Secuencia Artificial 

<220>
<223>  secuencia de aminocidos a1

<400>  8

Met Val Ser Lys Gly Glu Glu Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      


Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              


Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  


Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile 
65                  70                  75                  80  


Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      


Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln Asp Ser 
            100                 105                 110         


Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg Gly Thr 
        115                 120                 125             


Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 


Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 


Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu Val 
                165                 170                 175     


Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly 
            180                 185                 190         


Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             


Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His His Leu 
    210                 215                 220                 


Phe Leu Gly His Gly Thr Gly Ser Thr Gly Ser Gly Ser Ser Gly Thr 
225                 230                 235                 240 


Ala Ser Ser Glu Asp Asn Asn Met Ala Val Ile Lys Glu Phe Met Arg 
                245                 250                 255     


Phe Lys Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile 
            260                 265                 270         


Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys 
        275                 280                 285             


Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu 
    290                 295                 300                 


Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala 
305                 310                 315                 320 


Asp Ile Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp 
                325                 330                 335     


Glu Arg Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln 
            340                 345                 350         


Asp Ser Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg 
        355                 360                 365             


Gly Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met 
    370                 375                 380                 


Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu 
385                 390                 395                 400 


Lys Gly Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr 
                405                 410                 415     


Leu Val Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu 
            420                 425                 430         


Pro Gly Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn 
        435                 440                 445             


Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His 
    450                 455                 460                 


His Leu Phe Leu Tyr Gly Met Asp Glu Leu Tyr Lys Gly Thr Glu Leu 
465                 470                 475                 480 


Tyr Lys Ser Gly Gly Ser Gly Ser Gly Gly Gln Ser Gly Ser Gly Gly 
                485                 490                 495     


Gln Ser Gly Ser Gly Ser Gly Gln Ser Gly Leu Arg Ser Val Lys Leu 
            500                 505                 510         


Thr Ser Asp Phe Asp Asn Pro Arg Trp Ile Gly Arg His Lys His Met 
        515                 520                 525             


Phe Asn Phe Leu Asp Val Asn His Asn Gly Lys Ile Ser Leu Asp Glu 
    530                 535                 540                 


Met Val Tyr Lys Ala Ser Asp Ile Val Ile Asn Asn Leu Gly Ala Thr 
545                 550                 555                 560 


Pro Glu Gln Ala Lys Arg His Lys Asp Ala Val Glu Ala Phe Phe Gly 
                565                 570                 575     


Gly Ala Gly Met Lys Tyr Gly Val Glu Thr Asp Trp Pro Ala Tyr Ile 
            580                 585                 590         


Glu Gly Trp Lys Lys Leu Ala Thr Asp Glu Leu Glu Lys Tyr Ala Lys 
        595                 600                 605             


Asn Glu Pro Thr Leu Ile Arg Ile Trp Gly Asp Ala Leu Phe Asp Ile 
    610                 615                 620                 


Val Asp Lys Asp Gln Asn Gly Ala Ile Thr Leu Asp Glu Trp Lys Ala 
625                 630                 635                 640 


Tyr Thr Lys Ala Ala Gly Ile Ile Gln Ser Ser Glu Asp Cys Glu Glu 
                645                 650                 655     


Thr Phe Arg Val Cys Asp Ile Asp Glu Ser Gly Gln Leu Asp Val Asp 
            660                 665                 670         


Glu Met Thr Arg Gln His Leu Gly Phe Trp Tyr Thr Met Asp Pro Ala 
        675                 680                 685             


Cys Glu Lys Leu Tyr Gly Gly Ala Val Pro 
    690                 695                 


<210>  9
<211>  1950
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  secuencia de nucletidos A3

<400>  9
atggtgagca agggcgagga ggtcatcaaa gagttcatgc gcttcaaggt gcgcatggag       60

ggctccatga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag      120

ggcacccaga ccgccaagct gaaggtgacc aagggcggcc ccctgccctt cgcctgggac      180

atcctgtccc cccagttcat gtacggctcc aaggcgtacg tgaagcaccc cgccgacatc      240

cccgattaca agaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc      300

gaggacggcg gtctggtgac cgtgacccag gactcctccc tgcaggacgg cacgctgatc      360

tacaaggtga agatgcgcgg caccaacttc ccccccgacg gccccgtaat gcagaagaag      420

accatgggct gggaggcctc caccgagcgc ctgtaccccc gcgacggcgt gctgaagggc      480

gagatccacc aggccctgaa gctgaaggac ggcggccact acctggtgga gttcaagacc      540

atctacatgg ccaagaagcc cgtgcaactg cccggctact actacgtgga caccaagctg      600

gacatcacct cccacaacga ggactacacc atcgtggaac agtacgagcg ctccgagggc      660

cgccaccacc tgttcctggg gcatggcacc ggcagcaccg gcagcggcag ctccggcacc      720

gcctcctccg aggacaacaa catggccgtc atcaaagagt tcatgcgctt caaggtgcgc      780

atggagggct ccatgaacgg ccacgagttc gagatcgagg gcgagggcga gggccgcccc      840

tacgagggca cccagaccgc caagctgaag gtgaccaagg gcggccccct gcccttcgcc      900

tgggacatcc tgtcccccca gttcatgtac ggctccaagg cgtacgtgaa gcaccccgcc      960

gacatccccg attacaagaa gctgtccttc cccgagggct tcaagtggga gcgcgtgatg     1020

aacttcgagg acggcggtct ggtgaccgtg acccaggact cctccctgca ggacggcacg     1080

ctgatctaca aggtgaagat gcgcggcacc aacttccccc ccgacggccc cgtaatgcag     1140

aagaagacca tgggctggga ggcctccacc gagcgcctgt acccccgcga cggcgtgctg     1200

aagggcgaga tccaccaggc cctgaagctg aaggacggcg gccactacct ggtggagttc     1260

aagaccatct acatggccaa gaagcccgtg caactgcccg gctactacta cgtggacacc     1320

aagctggaca tcacctccca caacgaggac tacaccatcg tggaacagta cgagcgctcc     1380

gagggccgcc accacctgtt cctgtccgga ccaagatgga ttggacgaca caagcatatg     1440

ttcaatttcc ttgatgtcaa ccacaatgga aaaatctctc ttgacgagat ggtctacaag     1500

gcatctgata ttgtcatcaa taaccttgga gcaacacctg agcaagccaa acgacacaaa     1560

gatgctgtgg aagccttctt cggaggagct ggaatgaaat atggtgtgga aactgattgg     1620

cctgcatata ttgaaggatg gaaaaaattg gctactgatg aattggagaa atacgccaaa     1680

aacgaaccaa ccctcatccg catctggggt gatgctttgt ttgatatcgt tgacaaagat     1740

caaaatggag ctattacact ggatgaatgg aaagcataca ccaaagctgc tggtatcatc     1800

caatcatcag aagattgcga ggaaacattc agagtgtgcg atattgatga aagtggacaa     1860

ctcgatgttg atgagatgac aagacagcat ctgggatttt ggtacaccat ggatcctgct     1920

tgcgaaaagc tctacggtgg agctgtcccc                                      1950


<210>  10
<211>  650
<212>  PRT
<213>  Secuencia Artificial 

<220>
<223>  secuencia de aminocidos A3

<400>  10

Met Val Ser Lys Gly Glu Glu Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      


Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              


Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  


Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile 
65                  70                  75                  80  


Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      


Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln Asp Ser 
            100                 105                 110         


Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg Gly Thr 
        115                 120                 125             


Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 


Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 


Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu Val 
                165                 170                 175     


Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly 
            180                 185                 190         


Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             


Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His His Leu 
    210                 215                 220                 


Phe Leu Gly His Gly Thr Gly Ser Thr Gly Ser Gly Ser Ser Gly Thr 
225                 230                 235                 240 


Ala Ser Ser Glu Asp Asn Asn Met Ala Val Ile Lys Glu Phe Met Arg 
                245                 250                 255     


Phe Lys Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile 
            260                 265                 270         


Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys 
        275                 280                 285             


Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu 
    290                 295                 300                 


Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala 
305                 310                 315                 320 


Asp Ile Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp 
                325                 330                 335     


Glu Arg Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln 
            340                 345                 350         


Asp Ser Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg 
        355                 360                 365             


Gly Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met 
    370                 375                 380                 


Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu 
385                 390                 395                 400 


Lys Gly Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr 
                405                 410                 415     


Leu Val Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu 
            420                 425                 430         


Pro Gly Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn 
        435                 440                 445             


Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His 
    450                 455                 460                 


His Leu Phe Leu Ser Gly Pro Arg Trp Ile Gly Arg His Lys His Met 
465                 470                 475                 480 


Phe Asn Phe Leu Asp Val Asn His Asn Gly Lys Ile Ser Leu Asp Glu 
                485                 490                 495     


Met Val Tyr Lys Ala Ser Asp Ile Val Ile Asn Asn Leu Gly Ala Thr 
            500                 505                 510         


Pro Glu Gln Ala Lys Arg His Lys Asp Ala Val Glu Ala Phe Phe Gly 
        515                 520                 525             


Gly Ala Gly Met Lys Tyr Gly Val Glu Thr Asp Trp Pro Ala Tyr Ile 
    530                 535                 540                 


Glu Gly Trp Lys Lys Leu Ala Thr Asp Glu Leu Glu Lys Tyr Ala Lys 
545                 550                 555                 560 


Asn Glu Pro Thr Leu Ile Arg Ile Trp Gly Asp Ala Leu Phe Asp Ile 
                565                 570                 575     


Val Asp Lys Asp Gln Asn Gly Ala Ile Thr Leu Asp Glu Trp Lys Ala 
            580                 585                 590         


Tyr Thr Lys Ala Ala Gly Ile Ile Gln Ser Ser Glu Asp Cys Glu Glu 
        595                 600                 605             


Thr Phe Arg Val Cys Asp Ile Asp Glu Ser Gly Gln Leu Asp Val Asp 
    610                 615                 620                 


Glu Met Thr Arg Gln His Leu Gly Phe Trp Tyr Thr Met Asp Pro Ala 
625                 630                 635                 640 


Cys Glu Lys Leu Tyr Gly Gly Ala Val Pro 
                645                 650     


<210>  11
<211>  1941
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  secuencia de nucletidos B2

<400>  11
atggtgagca agggcgagga ggtcatcaaa gagttcatgc gcttcaaggt gcgcatggag       60

ggctccatga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag      120

ggcacccaga ccgccaagct gaaggtgacc aagggcggcc ccctgccctt cgcctgggac      180

atcctgtccc cccagttcat gtacggctcc aaggcgtacg tgaagcaccc cgccgacatc      240

cccgattaca agaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc      300

gaggacggcg gtctggtgac cgtgacccag gactcctccc tgcaggacgg cacgctgatc      360

tacaaggtga agatgcgcgg caccaacttc ccccccgacg gccccgtaat gcagaagaag      420

accatgggct gggaggcctc caccgagcgc ctgtaccccc gcgacggcgt gctgaagggc      480

gagatccacc aggccctgaa gctgaaggac ggcggccact acctggtgga gttcaagacc      540

atctacatgg ccaagaagcc cgtgcaactg cccggctact actacgtgga caccaagctg      600

gacatcacct cccacaacga ggactacacc atcgtggaac agtacgagcg ctccgagggc      660

cgccaccacc tgttcctggg gcatggcacc ggcagcaccg gcagcggcag ctccggcacc      720

gcctcctccg aggacaacaa catggccgtc atcaaagagt tcatgcgctt caaggtgcgc      780

atggagggct ccatgaacgg ccacgagttc gagatcgagg gcgagggcga gggccgcccc      840

tacgagggca cccagaccgc caagctgaag gtgaccaagg gcggccccct gcccttcgcc      900

tgggacatcc tgtcccccca gttcatgtac ggctccaagg cgtacgtgaa gcaccccgcc      960

gacatccccg attacaagaa gctgtccttc cccgagggct tcaagtggga gcgcgtgatg     1020

aacttcgagg acggcggtct ggtgaccgtg acccaggact cctccctgca ggacggcacg     1080

ctgatctaca aggtgaagat gcgcggcacc aacttccccc ccgacggccc cgtaatgcag     1140

aagaagacca tgggctggga ggcctccacc gagcgcctgt acccccgcga cggcgtgctg     1200

aagggcgaga tccaccaggc cctgaagctg aaggacggcg gccactacct ggtggagttc     1260

aagaccatct acatggccaa gaagcccgtg caactgcccg gctactacta cgtggacacc     1320

aagctggaca tcacctccca caacgaggac tacaccatcg tggaacagta cgagcgctcc     1380

gagggccgcc accactccgg accaagatgg attggacgac acaagcatat gttcaatttc     1440

cttgatgtca accacaatgg aaaaatctct cttgacgaga tggtctacaa ggcatctgat     1500

attgtcatca ataaccttgg agcaacacct gagcaagcca aacgacacaa agatgctgtg     1560

gaagccttct tcggaggagc tggaatgaaa tatggtgtgg aaactgattg gcctgcatat     1620

attgaaggat ggaaaaaatt ggctactgat gaattggaga aatacgccaa aaacgaacca     1680

accctcatcc gcatctgggg tgatgctttg tttgatatcg ttgacaaaga tcaaaatgga     1740

gctattacac tggatgaatg gaaagcatac accaaagctg ctggtatcat ccaatcatca     1800

gaagattgcg aggaaacatt cagagtgtgc gatattgatg aaagtggaca actcgatgtt     1860

gatgagatga caagacagca tctgggattt tggtacacca tggatcctgc ttgcgaaaag     1920

ctctacggtg gagctgtccc c                                               1941


<210>  12
<211>  647
<212>  PRT
<213>  Secuencia Artificial 

<220>
<223>  secuencia de aminocidos B2

<400>  12

Met Val Ser Lys Gly Glu Glu Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      


Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              


Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  


Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile 
65                  70                  75                  80  


Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      


Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln Asp Ser 
            100                 105                 110         


Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg Gly Thr 
        115                 120                 125             


Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 


Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 


Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu Val 
                165                 170                 175     


Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly 
            180                 185                 190         


Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             


Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His His Leu 
    210                 215                 220                 


Phe Leu Gly His Gly Thr Gly Ser Thr Gly Ser Gly Ser Ser Gly Thr 
225                 230                 235                 240 


Ala Ser Ser Glu Asp Asn Asn Met Ala Val Ile Lys Glu Phe Met Arg 
                245                 250                 255     


Phe Lys Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile 
            260                 265                 270         


Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys 
        275                 280                 285             


Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu 
    290                 295                 300                 


Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala 
305                 310                 315                 320 


Asp Ile Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp 
                325                 330                 335     


Glu Arg Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln 
            340                 345                 350         


Asp Ser Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg 
        355                 360                 365             


Gly Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met 
    370                 375                 380                 


Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu 
385                 390                 395                 400 


Lys Gly Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr 
                405                 410                 415     


Leu Val Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu 
            420                 425                 430         


Pro Gly Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn 
        435                 440                 445             


Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His 
    450                 455                 460                 


His Ser Gly Pro Arg Trp Ile Gly Arg His Lys His Met Phe Asn Phe 
465                 470                 475                 480 


Leu Asp Val Asn His Asn Gly Lys Ile Ser Leu Asp Glu Met Val Tyr 
                485                 490                 495     


Lys Ala Ser Asp Ile Val Ile Asn Asn Leu Gly Ala Thr Pro Glu Gln 
            500                 505                 510         


Ala Lys Arg His Lys Asp Ala Val Glu Ala Phe Phe Gly Gly Ala Gly 
        515                 520                 525             


Met Lys Tyr Gly Val Glu Thr Asp Trp Pro Ala Tyr Ile Glu Gly Trp 
    530                 535                 540                 


Lys Lys Leu Ala Thr Asp Glu Leu Glu Lys Tyr Ala Lys Asn Glu Pro 
545                 550                 555                 560 


Thr Leu Ile Arg Ile Trp Gly Asp Ala Leu Phe Asp Ile Val Asp Lys 
                565                 570                 575     


Asp Gln Asn Gly Ala Ile Thr Leu Asp Glu Trp Lys Ala Tyr Thr Lys 
            580                 585                 590         


Ala Ala Gly Ile Ile Gln Ser Ser Glu Asp Cys Glu Glu Thr Phe Arg 
        595                 600                 605             


Val Cys Asp Ile Asp Glu Ser Gly Gln Leu Asp Val Asp Glu Met Thr 
    610                 615                 620                 


Arg Gln His Leu Gly Phe Trp Tyr Thr Met Asp Pro Ala Cys Glu Lys 
625                 630                 635                 640 


Leu Tyr Gly Gly Ala Val Pro 
                645             


<210>  13
<211>  1986
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  secuencia de nucletidos AW

<400>  13
atggtgagca agggcgagga ggtcatcaaa gagttcatgc gcttcaaggt gcgcatggag       60

ggctccatga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag      120

ggcacccaga ccgccaagct gaaggtgacc aagggcggcc ccctgccctt cgcctgggac      180

atcctgtccc cccagttcat gtacggctcc aaggcgtacg tgaagcaccc cgccgacatc      240

cccgattaca agaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc      300

gaggacggcg gtctggtgac cgtgacccag gactcctccc tgcaggacgg cacgctgatc      360

tacaaggtga agatgcgcgg caccaacttc ccccccgacg gccccgtaat gcagaagaag      420

accatgggct gggaggcctc caccgagcgc ctgtaccccc gcgacggcgt gctgaagggc      480

gagatccacc aggccctgaa gctgaaggac ggcggccact acctggtgga gttcaagacc      540

atctacatgg ccaagaagcc cgtgcaactg cccggctact actacgtgga caccaagctg      600

gacatcacct cccacaacga ggactacacc atcgtggaac agtacgagcg ctccgagggc      660

cgccaccacc tgttcctggg gcatggcacc ggcagcaccg gcagcggcag ctccggcacc      720

gcctcctccg aggacaacaa catggccgtc atcaaagagt tcatgcgctt caaggtgcgc      780

atggagggct ccatgaacgg ccacgagttc gagatcgagg gcgagggcga gggccgcccc      840

tacgagggca cccagaccgc caagctgaag gtgaccaagg gcggccccct gcccttcgcc      900

tgggacatcc tgtcccccca gttcatgtac ggctccaagg cgtacgtgaa gcaccccgcc      960

gacatccccg attacaagaa gctgtccttc cccgagggct tcaagtggga gcgcgtgatg     1020

aacttcgagg acggcggtct ggtgaccgtg acccaggact cctccctgca ggacggcacg     1080

ctgatctaca aggtgaagat gcgcggcacc aacttccccc ccgacggccc cgtaatgcag     1140

aagaagacca tgggctggga ggcctccacc gagcgcctgt acccccgcga cggcgtgctg     1200

aagggcgaga tccaccaggc cctgaagctg aaggacggcg gccactacct ggtggagttc     1260

aagaccatct acatggccaa gaagcccgtg caactgcccg gctactacta cgtggacacc     1320

aagctggaca tcacctccca caacgaggac tacaccatcg tggaacagta cgagcgctcc     1380

gagggccgcc accacctgtt cctgtccgga ctcagatctg tcaaacttac atcagacttc     1440

gacaacccaa gatggattgg acgacacaag catatgttca atttccttga tgtcaaccac     1500

aatggaaaaa tctctcttga cgagatggtc tacaaggcat ctgatattgt catcaataac     1560

cttggagcaa cacctgagca agccaaacga cacaaagatg ctgtggaagc cttcttcgga     1620

ggagctggaa tgaaatatgg tgtggaaact gattggcctg catatattga aggatggaaa     1680

aaattggcta ctgatgaatt ggagaaatac gccaaaaacg aaccaaccct catccgcatc     1740

tggggtgatg ctttgtttga tatcgttgac aaagatcaaa atggagctat tacactggat     1800

gaatggaaag catacaccaa agctgctggt atcatccaat catcagaaga ttgcgaggaa     1860

acattcagag tgtgcgatat tgatgaaagt ggacaactcg atgttgatga gatgacaaga     1920

cagcatctgg gattttggta caccatggat cctgcttgcg aaaagctcta cggtggagct     1980

gtcccc                                                                1986


<210>  14
<211>  662
<212>  PRT
<213>  Secuencia Artificial 

<220>
<223>  secuencia de aminocidos AW

<400>  14

Met Val Ser Lys Gly Glu Glu Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      


Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              


Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  


Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile 
65                  70                  75                  80  


Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      


Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln Asp Ser 
            100                 105                 110         


Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg Gly Thr 
        115                 120                 125             


Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 


Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 


Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu Val 
                165                 170                 175     


Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly 
            180                 185                 190         


Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             


Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His His Leu 
    210                 215                 220                 


Phe Leu Gly His Gly Thr Gly Ser Thr Gly Ser Gly Ser Ser Gly Thr 
225                 230                 235                 240 


Ala Ser Ser Glu Asp Asn Asn Met Ala Val Ile Lys Glu Phe Met Arg 
                245                 250                 255     


Phe Lys Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile 
            260                 265                 270         


Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys 
        275                 280                 285             


Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu 
    290                 295                 300                 


Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala 
305                 310                 315                 320 


Asp Ile Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp 
                325                 330                 335     


Glu Arg Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln 
            340                 345                 350         


Asp Ser Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg 
        355                 360                 365             


Gly Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met 
    370                 375                 380                 


Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu 
385                 390                 395                 400 


Lys Gly Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr 
                405                 410                 415     


Leu Val Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu 
            420                 425                 430         


Pro Gly Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn 
        435                 440                 445             


Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His 
    450                 455                 460                 


His Leu Phe Leu Ser Gly Leu Arg Ser Val Lys Leu Thr Ser Asp Phe 
465                 470                 475                 480 


Asp Asn Pro Arg Trp Ile Gly Arg His Lys His Met Phe Asn Phe Leu 
                485                 490                 495     


Asp Val Asn His Asn Gly Lys Ile Ser Leu Asp Glu Met Val Tyr Lys 
            500                 505                 510         


Ala Ser Asp Ile Val Ile Asn Asn Leu Gly Ala Thr Pro Glu Gln Ala 
        515                 520                 525             


Lys Arg His Lys Asp Ala Val Glu Ala Phe Phe Gly Gly Ala Gly Met 
    530                 535                 540                 


Lys Tyr Gly Val Glu Thr Asp Trp Pro Ala Tyr Ile Glu Gly Trp Lys 
545                 550                 555                 560 


Lys Leu Ala Thr Asp Glu Leu Glu Lys Tyr Ala Lys Asn Glu Pro Thr 
                565                 570                 575     


Leu Ile Arg Ile Trp Gly Asp Ala Leu Phe Asp Ile Val Asp Lys Asp 
            580                 585                 590         


Gln Asn Gly Ala Ile Thr Leu Asp Glu Trp Lys Ala Tyr Thr Lys Ala 
        595                 600                 605             


Ala Gly Ile Ile Gln Ser Ser Glu Asp Cys Glu Glu Thr Phe Arg Val 
    610                 615                 620                 


Cys Asp Ile Asp Glu Ser Gly Gln Leu Asp Val Asp Glu Met Thr Arg 
625                 630                 635                 640 


Gln His Leu Gly Phe Trp Tyr Thr Met Asp Pro Ala Cys Glu Lys Leu 
                645                 650                 655     


Tyr Gly Gly Ala Val Pro 
            660             


<210>  15
<211>  1977
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  secuencia de nucletidos BW

<400>  15
atggtgagca agggcgagga ggtcatcaaa gagttcatgc gcttcaaggt gcgcatggag       60

ggctccatga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag      120

ggcacccaga ccgccaagct gaaggtgacc aagggcggcc ccctgccctt cgcctgggac      180

atcctgtccc cccagttcat gtacggctcc aaggcgtacg tgaagcaccc cgccgacatc      240

cccgattaca agaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc      300

gaggacggcg gtctggtgac cgtgacccag gactcctccc tgcaggacgg cacgctgatc      360

tacaaggtga agatgcgcgg caccaacttc ccccccgacg gccccgtaat gcagaagaag      420

accatgggct gggaggcctc caccgagcgc ctgtaccccc gcgacggcgt gctgaagggc      480

gagatccacc aggccctgaa gctgaaggac ggcggccact acctggtgga gttcaagacc      540

atctacatgg ccaagaagcc cgtgcaactg cccggctact actacgtgga caccaagctg      600

gacatcacct cccacaacga ggactacacc atcgtggaac agtacgagcg ctccgagggc      660

cgccaccacc tgttcctggg gcatggcacc ggcagcaccg gcagcggcag ctccggcacc      720

gcctcctccg aggacaacaa catggccgtc atcaaagagt tcatgcgctt caaggtgcgc      780

atggagggct ccatgaacgg ccacgagttc gagatcgagg gcgagggcga gggccgcccc      840

tacgagggca cccagaccgc caagctgaag gtgaccaagg gcggccccct gcccttcgcc      900

tgggacatcc tgtcccccca gttcatgtac ggctccaagg cgtacgtgaa gcaccccgcc      960

gacatccccg attacaagaa gctgtccttc cccgagggct tcaagtggga gcgcgtgatg     1020

aacttcgagg acggcggtct ggtgaccgtg acccaggact cctccctgca ggacggcacg     1080

ctgatctaca aggtgaagat gcgcggcacc aacttccccc ccgacggccc cgtaatgcag     1140

aagaagacca tgggctggga ggcctccacc gagcgcctgt acccccgcga cggcgtgctg     1200

aagggcgaga tccaccaggc cctgaagctg aaggacggcg gccactacct ggtggagttc     1260

aagaccatct acatggccaa gaagcccgtg caactgcccg gctactacta cgtggacacc     1320

aagctggaca tcacctccca caacgaggac tacaccatcg tggaacagta cgagcgctcc     1380

gagggccgcc accactccgg actcagatct gtcaaactta catcagactt cgacaaccca     1440

agatggattg gacgacacaa gcatatgttc aatttccttg atgtcaacca caatggaaaa     1500

atctctcttg acgagatggt ctacaaggca tctgatattg tcatcaataa ccttggagca     1560

acacctgagc aagccaaacg acacaaagat gctgtggaag ccttcttcgg aggagctgga     1620

atgaaatatg gtgtggaaac tgattggcct gcatatattg aaggatggaa aaaattggct     1680

actgatgaat tggagaaata cgccaaaaac gaaccaaccc tcatccgcat ctggggtgat     1740

gctttgtttg atatcgttga caaagatcaa aatggagcta ttacactgga tgaatggaaa     1800

gcatacacca aagctgctgg tatcatccaa tcatcagaag attgcgagga aacattcaga     1860

gtgtgcgata ttgatgaaag tggacaactc gatgttgatg agatgacaag acagcatctg     1920

ggattttggt acaccatgga tcctgcttgc gaaaagctct acggtggagc tgtcccc        1977


<210>  16
<211>  659
<212>  PRT
<213>  Secuencia Artificial 

<220>
<223>  secuencia de aminocidos BW

<400>  16

Met Val Ser Lys Gly Glu Glu Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      


Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              


Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  


Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile 
65                  70                  75                  80  


Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      


Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln Asp Ser 
            100                 105                 110         


Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg Gly Thr 
        115                 120                 125             


Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 


Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 


Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu Val 
                165                 170                 175     


Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly 
            180                 185                 190         


Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             


Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His His Leu 
    210                 215                 220                 


Phe Leu Gly His Gly Thr Gly Ser Thr Gly Ser Gly Ser Ser Gly Thr 
225                 230                 235                 240 


Ala Ser Ser Glu Asp Asn Asn Met Ala Val Ile Lys Glu Phe Met Arg 
                245                 250                 255     


Phe Lys Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile 
            260                 265                 270         


Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys 
        275                 280                 285             


Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu 
    290                 295                 300                 


Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala 
305                 310                 315                 320 


Asp Ile Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp 
                325                 330                 335     


Glu Arg Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln 
            340                 345                 350         


Asp Ser Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg 
        355                 360                 365             


Gly Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met 
    370                 375                 380                 


Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu 
385                 390                 395                 400 


Lys Gly Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr 
                405                 410                 415     


Leu Val Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu 
            420                 425                 430         


Pro Gly Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn 
        435                 440                 445             


Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His 
    450                 455                 460                 


His Ser Gly Leu Arg Ser Val Lys Leu Thr Ser Asp Phe Asp Asn Pro 
465                 470                 475                 480 


Arg Trp Ile Gly Arg His Lys His Met Phe Asn Phe Leu Asp Val Asn 
                485                 490                 495     


His Asn Gly Lys Ile Ser Leu Asp Glu Met Val Tyr Lys Ala Ser Asp 
            500                 505                 510         


Ile Val Ile Asn Asn Leu Gly Ala Thr Pro Glu Gln Ala Lys Arg His 
        515                 520                 525             


Lys Asp Ala Val Glu Ala Phe Phe Gly Gly Ala Gly Met Lys Tyr Gly 
    530                 535                 540                 


Val Glu Thr Asp Trp Pro Ala Tyr Ile Glu Gly Trp Lys Lys Leu Ala 
545                 550                 555                 560 


Thr Asp Glu Leu Glu Lys Tyr Ala Lys Asn Glu Pro Thr Leu Ile Arg 
                565                 570                 575     


Ile Trp Gly Asp Ala Leu Phe Asp Ile Val Asp Lys Asp Gln Asn Gly 
            580                 585                 590         


Ala Ile Thr Leu Asp Glu Trp Lys Ala Tyr Thr Lys Ala Ala Gly Ile 
        595                 600                 605             


Ile Gln Ser Ser Glu Asp Cys Glu Glu Thr Phe Arg Val Cys Asp Ile 
    610                 615                 620                 


Asp Glu Ser Gly Gln Leu Asp Val Asp Glu Met Thr Arg Gln His Leu 
625                 630                 635                 640 


Gly Phe Trp Tyr Thr Met Asp Pro Ala Cys Glu Lys Leu Tyr Gly Gly 
                645                 650                 655     


Ala Val Pro 
            


<210>  17
<211>  1974
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  secuencia de nucletidos AE

<400>  17
atggtgagca agggcgagga ggtcatcaaa gagttcatgc gcttcaaggt gcgcatggag       60

ggctccatga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag      120

ggcacccaga ccgccaagct gaaggtgacc aagggcggcc ccctgccctt cgcctgggac      180

atcctgtccc cccagttcat gtacggctcc aaggcgtacg tgaagcaccc cgccgacatc      240

cccgattaca agaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc      300

gaggacggcg gtctggtgac cgtgacccag gactcctccc tgcaggacgg cacgctgatc      360

tacaaggtga agatgcgcgg caccaacttc ccccccgacg gccccgtaat gcagaagaag      420

accatgggct gggaggcctc caccgagcgc ctgtaccccc gcgacggcgt gctgaagggc      480

gagatccacc aggccctgaa gctgaaggac ggcggccact acctggtgga gttcaagacc      540

atctacatgg ccaagaagcc cgtgcaactg cccggctact actacgtgga caccaagctg      600

gacatcacct cccacaacga ggactacacc atcgtggaac agtacgagcg ctccgagggc      660

cgccaccacc tgttcctggg gcatggcacc ggcagcaccg gcagcggcag ctccggcacc      720

gcctcctccg aggacaacaa catggccgtc atcaaagagt tcatgcgctt caaggtgcgc      780

atggagggct ccatgaacgg ccacgagttc gagatcgagg gcgagggcga gggccgcccc      840

tacgagggca cccagaccgc caagctgaag gtgaccaagg gcggccccct gcccttcgcc      900

tgggacatcc tgtcccccca gttcatgtac ggctccaagg cgtacgtgaa gcaccccgcc      960

gacatccccg attacaagaa gctgtccttc cccgagggct tcaagtggga gcgcgtgatg     1020

aacttcgagg acggcggtct ggtgaccgtg acccaggact cctccctgca ggacggcacg     1080

ctgatctaca aggtgaagat gcgcggcacc aacttccccc ccgacggccc cgtaatgcag     1140

aagaagacca tgggctggga ggcctccacc gagcgcctgt acccccgcga cggcgtgctg     1200

aagggcgaga tccaccaggc cctgaagctg aaggacggcg gccactacct ggtggagttc     1260

aagaccatct acatggccaa gaagcccgtg caactgcccg gctactacta cgtggacacc     1320

aagctggaca tcacctccca caacgaggac tacaccatcg tggaacagta cgagcgctcc     1380

gagggccgcc accacctgtt cctgtccgga aaacttacat cagacttcga caacccaaga     1440

tggattggac gacacaagca tatgttcaat ttccttgatg tcaaccacaa tggaaaaatc     1500

tctcttgacg agatggtcta caaggcatct gatattgtca tcaataacct tggagcaaca     1560

cctgagcaag ccaaacgaca caaagatgct gtggaagcct tcttcggagg agctggaatg     1620

aaatatggtg tggaaactga ttggcctgca tatattgaag gatggaaaaa attggctact     1680

gatgaattgg agaaatacgc caaaaacgaa ccaaccctca tccgcatctg gggtgatgct     1740

ttgtttgata tcgttgacaa agatcaaaat ggagctatta cactggatga atggaaagca     1800

tacaccaaag ctgctggtat catccaatca tcagaagatt gcgaggaaac attcagagtg     1860

tgcgatattg atgaaagtgg acaactcgat gttgatgaga tgacaagaca gcatctggga     1920

ttttggtaca ccatggatcc tgcttgcgaa aagctctacg gtggagctgt cccc           1974


<210>  18
<211>  658
<212>  PRT
<213>  Secuencia Artificial 

<220>
<223>  secuencia de aminocidos AE

<400>  18

Met Val Ser Lys Gly Glu Glu Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      


Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              


Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  


Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile 
65                  70                  75                  80  


Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      


Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln Asp Ser 
            100                 105                 110         


Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg Gly Thr 
        115                 120                 125             


Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 


Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 


Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu Val 
                165                 170                 175     


Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly 
            180                 185                 190         


Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             


Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His His Leu 
    210                 215                 220                 


Phe Leu Gly His Gly Thr Gly Ser Thr Gly Ser Gly Ser Ser Gly Thr 
225                 230                 235                 240 


Ala Ser Ser Glu Asp Asn Asn Met Ala Val Ile Lys Glu Phe Met Arg 
                245                 250                 255     


Phe Lys Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile 
            260                 265                 270         


Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys 
        275                 280                 285             


Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu 
    290                 295                 300                 


Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala 
305                 310                 315                 320 


Asp Ile Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp 
                325                 330                 335     


Glu Arg Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln 
            340                 345                 350         


Asp Ser Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg 
        355                 360                 365             


Gly Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met 
    370                 375                 380                 


Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu 
385                 390                 395                 400 


Lys Gly Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr 
                405                 410                 415     


Leu Val Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu 
            420                 425                 430         


Pro Gly Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn 
        435                 440                 445             


Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His 
    450                 455                 460                 


His Leu Phe Leu Ser Gly Lys Leu Thr Ser Asp Phe Asp Asn Pro Arg 
465                 470                 475                 480 


Trp Ile Gly Arg His Lys His Met Phe Asn Phe Leu Asp Val Asn His 
                485                 490                 495     


Asn Gly Lys Ile Ser Leu Asp Glu Met Val Tyr Lys Ala Ser Asp Ile 
            500                 505                 510         


Val Ile Asn Asn Leu Gly Ala Thr Pro Glu Gln Ala Lys Arg His Lys 
        515                 520                 525             


Asp Ala Val Glu Ala Phe Phe Gly Gly Ala Gly Met Lys Tyr Gly Val 
    530                 535                 540                 


Glu Thr Asp Trp Pro Ala Tyr Ile Glu Gly Trp Lys Lys Leu Ala Thr 
545                 550                 555                 560 


Asp Glu Leu Glu Lys Tyr Ala Lys Asn Glu Pro Thr Leu Ile Arg Ile 
                565                 570                 575     


Trp Gly Asp Ala Leu Phe Asp Ile Val Asp Lys Asp Gln Asn Gly Ala 
            580                 585                 590         


Ile Thr Leu Asp Glu Trp Lys Ala Tyr Thr Lys Ala Ala Gly Ile Ile 
        595                 600                 605             


Gln Ser Ser Glu Asp Cys Glu Glu Thr Phe Arg Val Cys Asp Ile Asp 
    610                 615                 620                 


Glu Ser Gly Gln Leu Asp Val Asp Glu Met Thr Arg Gln His Leu Gly 
625                 630                 635                 640 


Phe Trp Tyr Thr Met Asp Pro Ala Cys Glu Lys Leu Tyr Gly Gly Ala 
                645                 650                 655     


Val Pro 
            


<210>  19
<211>  1959
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  secuencia de nucletidos AD1

<400>  19
atggtgagca agggcgagga ggtcatcaaa gagttcatgc gcttcaaggt gcgcatggag       60

ggctccatga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag      120

ggcacccaga ccgccaagct gaaggtgacc aagggcggcc ccctgccctt cgcctgggac      180

atcctgtccc cccagttcat gtacggctcc aaggcgtacg tgaagcaccc cgccgacatc      240

cccgattaca agaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc      300

gaggacggcg gtctggtgac cgtgacccag gactcctccc tgcaggacgg cacgctgatc      360

tacaaggtga agatgcgcgg caccaacttc ccccccgacg gccccgtaat gcagaagaag      420

accatgggct gggaggcctc caccgagcgc ctgtaccccc gcgacggcgt gctgaagggc      480

gagatccacc aggccctgaa gctgaaggac ggcggccact acctggtgga gttcaagacc      540

atctacatgg ccaagaagcc cgtgcaactg cccggctact actacgtgga caccaagctg      600

gacatcacct cccacaacga ggactacacc atcgtggaac agtacgagcg ctccgagggc      660

cgccaccacc tgttcctggg gcatggcacc ggcagcaccg gcagcggcag ctccggcacc      720

gcctcctccg aggacaacaa catggccgtc atcaaagagt tcatgcgctt caaggtgcgc      780

atggagggct ccatgaacgg ccacgagttc gagatcgagg gcgagggcga gggccgcccc      840

tacgagggca cccagaccgc caagctgaag gtgaccaagg gcggccccct gcccttcgcc      900

tgggacatcc tgtcccccca gttcatgtac ggctccaagg cgtacgtgaa gcaccccgcc      960

gacatccccg attacaagaa gctgtccttc cccgagggct tcaagtggga gcgcgtgatg     1020

aacttcgagg acggcggtct ggtgaccgtg acccaggact cctccctgca ggacggcacg     1080

ctgatctaca aggtgaagat gcgcggcacc aacttccccc ccgacggccc cgtaatgcag     1140

aagaagacca tgggctggga ggcctccacc gagcgcctgt acccccgcga cggcgtgctg     1200

aagggcgaga tccaccaggc cctgaagctg aaggacggcg gccactacct ggtggagttc     1260

aagaccatct acatggccaa gaagcccgtg caactgcccg gctactacta cgtggacacc     1320

aagctggaca tcacctccca caacgaggac tacaccatcg tggaacagta cgagcgctcc     1380

gagggccgcc accacctgtt cctgtccgga ttcgacaacc caagatggat tggacgacac     1440

aagcatatgt tcaatttcct tgatgtcaac cacaatggaa aaatctctct tgacgagatg     1500

gtctacaagg catctgatat tgtcatcaat aaccttggag caacacctga gcaagccaaa     1560

cgacacaaag atgctgtgga agccttcttc ggaggagctg gaatgaaata tggtgtggaa     1620

actgattggc ctgcatatat tgaaggatgg aaaaaattgg ctactgatga attggagaaa     1680

tacgccaaaa acgaaccaac cctcatccgc atctggggtg atgctttgtt tgatatcgtt     1740

gacaaagatc aaaatggagc tattacactg gatgaatgga aagcatacac caaagctgct     1800

ggtatcatcc aatcatcaga agattgcgag gaaacattca gagtgtgcga tattgatgaa     1860

agtggacaac tcgatgttga tgagatgaca agacagcatc tgggattttg gtacaccatg     1920

gatcctgctt gcgaaaagct ctacggtgga gctgtcccc                            1959


<210>  20
<211>  653
<212>  PRT
<213>  Secuencia Artificial 

<220>
<223>  secuencia de aminocidos AD1

<400>  20

Met Val Ser Lys Gly Glu Glu Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      


Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              


Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  


Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile 
65                  70                  75                  80  


Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      


Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln Asp Ser 
            100                 105                 110         


Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg Gly Thr 
        115                 120                 125             


Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 


Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 


Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu Val 
                165                 170                 175     


Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly 
            180                 185                 190         


Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             


Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His His Leu 
    210                 215                 220                 


Phe Leu Gly His Gly Thr Gly Ser Thr Gly Ser Gly Ser Ser Gly Thr 
225                 230                 235                 240 


Ala Ser Ser Glu Asp Asn Asn Met Ala Val Ile Lys Glu Phe Met Arg 
                245                 250                 255     


Phe Lys Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile 
            260                 265                 270         


Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys 
        275                 280                 285             


Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu 
    290                 295                 300                 


Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala 
305                 310                 315                 320 


Asp Ile Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp 
                325                 330                 335     


Glu Arg Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln 
            340                 345                 350         


Asp Ser Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg 
        355                 360                 365             


Gly Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met 
    370                 375                 380                 


Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu 
385                 390                 395                 400 


Lys Gly Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr 
                405                 410                 415     


Leu Val Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu 
            420                 425                 430         


Pro Gly Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn 
        435                 440                 445             


Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His 
    450                 455                 460                 


His Leu Phe Leu Ser Gly Phe Asp Asn Pro Arg Trp Ile Gly Arg His 
465                 470                 475                 480 


Lys His Met Phe Asn Phe Leu Asp Val Asn His Asn Gly Lys Ile Ser 
                485                 490                 495     


Leu Asp Glu Met Val Tyr Lys Ala Ser Asp Ile Val Ile Asn Asn Leu 
            500                 505                 510         


Gly Ala Thr Pro Glu Gln Ala Lys Arg His Lys Asp Ala Val Glu Ala 
        515                 520                 525             


Phe Phe Gly Gly Ala Gly Met Lys Tyr Gly Val Glu Thr Asp Trp Pro 
    530                 535                 540                 


Ala Tyr Ile Glu Gly Trp Lys Lys Leu Ala Thr Asp Glu Leu Glu Lys 
545                 550                 555                 560 


Tyr Ala Lys Asn Glu Pro Thr Leu Ile Arg Ile Trp Gly Asp Ala Leu 
                565                 570                 575     


Phe Asp Ile Val Asp Lys Asp Gln Asn Gly Ala Ile Thr Leu Asp Glu 
            580                 585                 590         


Trp Lys Ala Tyr Thr Lys Ala Ala Gly Ile Ile Gln Ser Ser Glu Asp 
        595                 600                 605             


Cys Glu Glu Thr Phe Arg Val Cys Asp Ile Asp Glu Ser Gly Gln Leu 
    610                 615                 620                 


Asp Val Asp Glu Met Thr Arg Gln His Leu Gly Phe Trp Tyr Thr Met 
625                 630                 635                 640 


Asp Pro Ala Cys Glu Lys Leu Tyr Gly Gly Ala Val Pro 
                645                 650                 


<210>  21
<211>  1959
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  secuencia de nucletidos Alfa

<400>  21
atggtgagca agggcgagga ggtcatcaaa gagttcatgc gcttcaaggt gcgcatggag       60

ggctccatga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag      120

ggcacccaga ccgccaagct gaaggtgacc aagggcggcc ccctgccctt cgcctgggac      180

atcctgtccc cccagttcat gtacggctcc aaggcgtacg tgaagcaccc cgccgacatc      240

cccgattaca agaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc      300

gaggacggcg gtctggtgac cgtgacccag gactcctccc tgcaggacgg cacgctgatc      360

tacaaggtga agatgcgcgg caccaacttc ccccccgacg gccccgtaat gcagaagaag      420

accatgggct gggaggcctc caccgagcgc ctgtaccccc gcgacggcgt gctgaagggc      480

gagatccacc aggccctgaa gctgaaggac ggcggccact acctggtgga gttcaagacc      540

atctacatgg ccaagaagcc cgtgcaactg cccggctact actacgtgga caccaagctg      600

gacatcacct cccacaacga ggactacacc atcgtggaac agtacgagcg ctccgagggc      660

cgccaccacc tgttcctggg gcatggcacc ggcagcaccg gcagcggcag ctccggcacc      720

gcctcctccg aggacaacaa catggccgtc atcaaagagt tcatgcgctt caaggtgcgc      780

atggagggct ccatgaacgg ccacgagttc gagatcgagg gcgagggcga gggccgcccc      840

tacgagggca cccagaccgc caagctgaag gtgaccaagg gcggccccct gcccttcgcc      900

tgggacatcc tgtcccccca gttcatgtac ggctccaagg cgtacgtgaa gcaccccgcc      960

gacatccccg attacaagaa gctgtccttc cccgagggct tcaagtggga gcgcgtgatg     1020

aacttcgagg acggcggtct ggtgaccgtg acccaggact cctccctgca ggacggcacg     1080

ctgatctaca aggtgaagat gcgcggcacc aacttccccc ccgacggccc cgtaatgcag     1140

aagaagacca tgggctggga ggcctccacc gagcgcctgt acccccgcga cggcgtgctg     1200

aagggcgaga tccaccaggc cctgaagctg aaggacggcg gccactacct ggtggagttc     1260

aagaccatct acatggccaa gaagcccgtg caactgcccg gctactacta cgtggacacc     1320

aagctggaca tcacctccca caacgaggac tacaccatcg tggaacagta cgagcgctcc     1380

gagggccgcc accacctgtt cctgtccgac ttcgacaacc caagatggat tggacgacac     1440

aagcatatgt tcaatttcct tgatgtcaac cacaatggaa aaatctctct tgacgagatg     1500

gtctacaagg catctgatat tgtcatcaat aaccttggag caacacctga gcaagccaaa     1560

cgacacaaag atgctgtgga agccttcttc ggaggagctg gaatgaaata tggtgtggaa     1620

actgattggc ctgcatatat tgaaggatgg aaaaaattgg ctactgatga attggagaaa     1680

tacgccaaaa acgaaccaac cctcatccgc atctggggtg atgctttgtt tgatatcgtt     1740

gacaaagatc aaaatggagc tattacactg gatgaatgga aagcatacac caaagctgct     1800

ggtatcatcc aatcatcaga agattgcgag gaaacattca gagtgtgcga tattgatgaa     1860

agtggacaac tcgatgttga tgagatgaca agacagcatc tgggattttg gtacaccatg     1920

gatcctgctt gcgaaaagct ctacggtgga gctgtcccc                            1959


<210>  22
<211>  653
<212>  PRT
<213>  Secuencia Artificial 

<220>
<223>  secuencia de aminocidos Alfa

<400>  22

Met Val Ser Lys Gly Glu Glu Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      


Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              


Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  


Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile 
65                  70                  75                  80  


Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      


Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln Asp Ser 
            100                 105                 110         


Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg Gly Thr 
        115                 120                 125             


Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 


Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 


Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu Val 
                165                 170                 175     


Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly 
            180                 185                 190         


Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             


Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His His Leu 
    210                 215                 220                 


Phe Leu Gly His Gly Thr Gly Ser Thr Gly Ser Gly Ser Ser Gly Thr 
225                 230                 235                 240 


Ala Ser Ser Glu Asp Asn Asn Met Ala Val Ile Lys Glu Phe Met Arg 
                245                 250                 255     


Phe Lys Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile 
            260                 265                 270         


Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys 
        275                 280                 285             


Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu 
    290                 295                 300                 


Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala 
305                 310                 315                 320 


Asp Ile Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp 
                325                 330                 335     


Glu Arg Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln 
            340                 345                 350         


Asp Ser Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg 
        355                 360                 365             


Gly Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met 
    370                 375                 380                 


Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu 
385                 390                 395                 400 


Lys Gly Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr 
                405                 410                 415     


Leu Val Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu 
            420                 425                 430         


Pro Gly Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn 
        435                 440                 445             


Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His 
    450                 455                 460                 


His Leu Phe Leu Ser Asp Phe Asp Asn Pro Arg Trp Ile Gly Arg His 
465                 470                 475                 480 


Lys His Met Phe Asn Phe Leu Asp Val Asn His Asn Gly Lys Ile Ser 
                485                 490                 495     


Leu Asp Glu Met Val Tyr Lys Ala Ser Asp Ile Val Ile Asn Asn Leu 
            500                 505                 510         


Gly Ala Thr Pro Glu Gln Ala Lys Arg His Lys Asp Ala Val Glu Ala 
        515                 520                 525             


Phe Phe Gly Gly Ala Gly Met Lys Tyr Gly Val Glu Thr Asp Trp Pro 
    530                 535                 540                 


Ala Tyr Ile Glu Gly Trp Lys Lys Leu Ala Thr Asp Glu Leu Glu Lys 
545                 550                 555                 560 


Tyr Ala Lys Asn Glu Pro Thr Leu Ile Arg Ile Trp Gly Asp Ala Leu 
                565                 570                 575     


Phe Asp Ile Val Asp Lys Asp Gln Asn Gly Ala Ile Thr Leu Asp Glu 
            580                 585                 590         


Trp Lys Ala Tyr Thr Lys Ala Ala Gly Ile Ile Gln Ser Ser Glu Asp 
        595                 600                 605             


Cys Glu Glu Thr Phe Arg Val Cys Asp Ile Asp Glu Ser Gly Gln Leu 
    610                 615                 620                 


Asp Val Asp Glu Met Thr Arg Gln His Leu Gly Phe Trp Tyr Thr Met 
625                 630                 635                 640 


Asp Pro Ala Cys Glu Lys Leu Tyr Gly Gly Ala Val Pro
                645                 650                 


<210>  23
<211>  1959
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  secuencia de nucletidos Beta

<400>  23
atggtgagca agggcgagga ggtcatcaaa gagttcatgc gcttcaaggt gcgcatggag       60

ggctccatga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag      120

ggcacccaga ccgccaagct gaaggtgacc aagggcggcc ccctgccctt cgcctgggac      180

atcctgtccc cccagttcat gtacggctcc aaggcgtacg tgaagcaccc cgccgacatc      240

cccgattaca agaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc      300

gaggacggcg gtctggtgac cgtgacccag gactcctccc tgcaggacgg cacgctgatc      360

tacaaggtga agatgcgcgg caccaacttc ccccccgacg gccccgtaat gcagaagaag      420

accatgggct gggaggcctc caccgagcgc ctgtaccccc gcgacggcgt gctgaagggc      480

gagatccacc aggccctgaa gctgaaggac ggcggccact acctggtgga gttcaagacc      540

atctacatgg ccaagaagcc cgtgcaactg cccggctact actacgtgga caccaagctg      600

gacatcacct cccacaacga ggactacacc atcgtggaac agtacgagcg ctccgagggc      660

cgccaccacc tgttcctggg gcatggcacc ggcagcaccg gcagcggcag ctccggcacc      720

gcctcctccg aggacaacaa catggccgtc atcaaagagt tcatgcgctt caaggtgcgc      780

atggagggct ccatgaacgg ccacgagttc gagatcgagg gcgagggcga gggccgcccc      840

tacgagggca cccagaccgc caagctgaag gtgaccaagg gcggccccct gcccttcgcc      900

tgggacatcc tgtcccccca gttcatgtac ggctccaagg cgtacgtgaa gcaccccgcc      960

gacatccccg attacaagaa gctgtccttc cccgagggct tcaagtggga gcgcgtgatg     1020

aacttcgagg acggcggtct ggtgaccgtg acccaggact cctccctgca ggacggcacg     1080

ctgatctaca aggtgaagat gcgcggcacc aacttccccc ccgacggccc cgtaatgcag     1140

aagaagacca tgggctggga ggcctccacc gagcgcctgt acccccgcga cggcgtgctg     1200

aagggcgaga tccaccaggc cctgaagctg aaggacggcg gccactacct ggtggagttc     1260

aagaccatct acatggccaa gaagcccgtg caactgcccg gctactacta cgtggacacc     1320

aagctggaca tcacctccca caacgaggac tacaccatcg tggaacagta cgagcgctcc     1380

gagggccgcc accacctgct gctgtccgga ttcgacaacc caagatggat tggacgacac     1440

aagcatatgt tcaatttcct tgatgtcaac cacaatggaa aaatctctct tgacgagatg     1500

gtctacaagg catctgatat tgtcatcaat aaccttggag caacacctga gcaagccaaa     1560

cgacacaaag atgctgtgga agccttcttc ggaggagctg gaatgaaata tggtgtggaa     1620

actgattggc ctgcatatat tgaaggatgg aaaaaattgg ctactgatga attggagaaa     1680

tacgccaaaa acgaaccaac cctcatccgc atctggggtg atgctttgtt tgatatcgtt     1740

gacaaagatc aaaatggagc tattacactg gatgaatgga aagcatacac caaagctgct     1800

ggtatcatcc aatcatcaga agattgcgag gaaacattca gagtgtgcga tattgatgaa     1860

agtggacaac tcgatgttga tgagatgaca agacagcatc tgggattttg gtacaccatg     1920

gatcctgctt gcgaaaagct ctacggtgga gctgtcccc                            1959


<210>  24
<211>  653
<212>  PRT
<213>  Secuencia Artificial 

<220>
<223>  secuencia de aminocidos Beta

<400>  24

Met Val Ser Lys Gly Glu Glu Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      


Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              


Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  


Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile 
65                  70                  75                  80  


Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      


Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln Asp Ser 
            100                 105                 110         


Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg Gly Thr 
        115                 120                 125             


Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 


Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 


Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu Val 
                165                 170                 175     


Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly 
            180                 185                 190         


Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             


Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His His Leu 
    210                 215                 220                 


Phe Leu Gly His Gly Thr Gly Ser Thr Gly Ser Gly Ser Ser Gly Thr 
225                 230                 235                 240 


Ala Ser Ser Glu Asp Asn Asn Met Ala Val Ile Lys Glu Phe Met Arg 
                245                 250                 255     


Phe Lys Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile 
            260                 265                 270         


Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys 
        275                 280                 285             


Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu 
    290                 295                 300                 


Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala 
305                 310                 315                 320 


Asp Ile Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp 
                325                 330                 335     


Glu Arg Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln 
            340                 345                 350         


Asp Ser Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg 
        355                 360                 365             


Gly Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met 
    370                 375                 380                 


Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu 
385                 390                 395                 400 


Lys Gly Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr 
                405                 410                 415     


Leu Val Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu 
            420                 425                 430         


Pro Gly Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn 
        435                 440                 445             


Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His 
    450                 455                 460                 


His Leu Leu Leu Ser Gly Phe Asp Asn Pro Arg Trp Ile Gly Arg His 
465                 470                 475                 480 


Lys His Met Phe Asn Phe Leu Asp Val Asn His Asn Gly Lys Ile Ser 
                485                 490                 495     


Leu Asp Glu Met Val Tyr Lys Ala Ser Asp Ile Val Ile Asn Asn Leu 
            500                 505                 510         


Gly Ala Thr Pro Glu Gln Ala Lys Arg His Lys Asp Ala Val Glu Ala 
        515                 520                 525             


Phe Phe Gly Gly Ala Gly Met Lys Tyr Gly Val Glu Thr Asp Trp Pro 
    530                 535                 540                 


Ala Tyr Ile Glu Gly Trp Lys Lys Leu Ala Thr Asp Glu Leu Glu Lys 
545                 550                 555                 560 


Tyr Ala Lys Asn Glu Pro Thr Leu Ile Arg Ile Trp Gly Asp Ala Leu 
                565                 570                 575     


Phe Asp Ile Val Asp Lys Asp Gln Asn Gly Ala Ile Thr Leu Asp Glu 
            580                 585                 590         


Trp Lys Ala Tyr Thr Lys Ala Ala Gly Ile Ile Gln Ser Ser Glu Asp 
        595                 600                 605             


Cys Glu Glu Thr Phe Arg Val Cys Asp Ile Asp Glu Ser Gly Gln Leu 
    610                 615                 620                 


Asp Val Asp Glu Met Thr Arg Gln His Leu Gly Phe Trp Tyr Thr Met 
625                 630                 635                 640 


Asp Pro Ala Cys Glu Lys Leu Tyr Gly Gly Ala Val Pro 
                645                 650                 


<210>  25
<211>  1977
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  secuencia de nucletidos ADiFL

<400>  25
atggtgagca agggcgagga ggtcatcaaa gagttcatgc gcttcaaggt gcgcatggag       60

ggctccatga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag      120

ggcacccaga ccgccaagct gaaggtgacc aagggcggcc ccctgccctt cgcctgggac      180

atcctgtccc cccagttcat gtacggctcc aaggcgtacg tgaagcaccc cgccgacatc      240

cccgattaca agaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc      300

gaggacggcg gtctggtgac cgtgacccag gactcctccc tgcaggacgg cacgctgatc      360

tacaaggtga agatgcgcgg caccaacttc ccccccgacg gccccgtaat gcagaagaag      420

accatgggct gggaggcctc caccgagcgc ctgtaccccc gcgacggcgt gctgaagggc      480

gagatccacc aggccctgaa gctgaaggac ggcggccact acctggtgga gttcaagacc      540

atctacatgg ccaagaagcc cgtgcaactg cccggctact actacgtgga caccaagctg      600

gacatcacct cccacaacga ggactacacc atcgtggaac agtacgagcg ctccgagggc      660

cgccaccacc tgttcctggg gcatggcacc ggcagcaccg gcagcggcag ctccggcacc      720

gcctcctccg aggacaacaa catggccgtc atcaaagagt tcatgcgctt caaggtgcgc      780

atggagggct ccatgaacgg ccacgagttc gagatcgagg gcgagggcga gggccgcccc      840

tacgagggca cccagaccgc caagctgaag gtgaccaagg gcggccccct gcccttcgcc      900

tgggacatcc tgtcccccca gttcatgtac ggctccaagg cgtacgtgaa gcaccccgcc      960

gacatccccg attacaagaa gctgtccttc cccgagggct tcaagtggga gcgcgtgatg     1020

aacttcgagg acggcggtct ggtgaccgtg acccaggact cctccctgca ggacggcacg     1080

ctgatctaca aggtgaagat gcgcggcacc aacttccccc ccgacggccc cgtaatgcag     1140

aagaagacca tgggctggga ggcctccacc gagcgcctgt acccccgcga cggcgtgctg     1200

aagggcgaga tccaccaggc cctgaagctg aaggacggcg gccactacct ggtggagttc     1260

aagaccatct acatggccaa gaagcccgtg caactgcccg gctactacta cgtggacacc     1320

aagctggaca tcacctccca caacgaggac tacaccatcg tggaacagta cgagcgctcc     1380

gagggccgcc accacctgtt cctgtccggc gggagcggat cctccggatt cgacaaccca     1440

agatggattg gacgacacaa gcatatgttc aatttccttg atgtcaacca caatggaaaa     1500

atctctcttg acgagatggt ctacaaggca tctgatattg tcatcaataa ccttggagca     1560

acacctgagc aagccaaacg acacaaagat gctgtggaag ccttcttcgg aggagctgga     1620

atgaaatatg gtgtggaaac tgattggcct gcatttattg aaggatggaa aaaattggct     1680

actgatgaat tggagaaata cgccaaaaac gaaccaaccc tcatccgcat ctggggtgat     1740

gctttgtttg atatcgttga caaagatcaa aatggagcta ttacactgga tgaatggaaa     1800

gcatacacca aagctgctgg tatcatccaa tcatcagaag attgcgagga aacattcaga     1860

gtgtgcgata ttgatgaaag tggacaactc gatgttgatg agatgacaag acagcatctg     1920

ggattttggt acaccatgga tcctgcttgc gaaaagctct acggtggagc tgtcccc        1977


<210>  26
<211>  659
<212>  PRT
<213>  Secuencia Artificial 

<220>
<223>  secuencia de aminocidos ADiFL

<400>  26

Met Val Ser Lys Gly Glu Glu Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      


Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              


Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  


Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile 
65                  70                  75                  80  


Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      


Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln Asp Ser 
            100                 105                 110         


Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg Gly Thr 
        115                 120                 125             


Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 


Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 


Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu Val 
                165                 170                 175     


Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly 
            180                 185                 190         


Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             


Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His His Leu 
    210                 215                 220                 


Phe Leu Gly His Gly Thr Gly Ser Thr Gly Ser Gly Ser Ser Gly Thr 
225                 230                 235                 240 


Ala Ser Ser Glu Asp Asn Asn Met Ala Val Ile Lys Glu Phe Met Arg 
                245                 250                 255     


Phe Lys Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile 
            260                 265                 270         


Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys 
        275                 280                 285             


Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu 
    290                 295                 300                 


Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala 
305                 310                 315                 320 


Asp Ile Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp 
                325                 330                 335     


Glu Arg Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln 
            340                 345                 350         


Asp Ser Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg 
        355                 360                 365             


Gly Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met 
    370                 375                 380                 


Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu 
385                 390                 395                 400 


Lys Gly Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr 
                405                 410                 415     


Leu Val Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu 
            420                 425                 430         


Pro Gly Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn 
        435                 440                 445             


Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His 
    450                 455                 460                 


His Leu Phe Leu Ser Gly Gly Ser Gly Ser Ser Gly Phe Asp Asn Pro 
465                 470                 475                 480 


Arg Trp Ile Gly Arg His Lys His Met Phe Asn Phe Leu Asp Val Asn 
                485                 490                 495     


His Asn Gly Lys Ile Ser Leu Asp Glu Met Val Tyr Lys Ala Ser Asp 
            500                 505                 510         


Ile Val Ile Asn Asn Leu Gly Ala Thr Pro Glu Gln Ala Lys Arg His 
        515                 520                 525             


Lys Asp Ala Val Glu Ala Phe Phe Gly Gly Ala Gly Met Lys Tyr Gly 
    530                 535                 540                 


Val Glu Thr Asp Trp Pro Ala Phe Ile Glu Gly Trp Lys Lys Leu Ala 
545                 550                 555                 560 


Thr Asp Glu Leu Glu Lys Tyr Ala Lys Asn Glu Pro Thr Leu Ile Arg 
                565                 570                 575     


Ile Trp Gly Asp Ala Leu Phe Asp Ile Val Asp Lys Asp Gln Asn Gly 
            580                 585                 590         


Ala Ile Thr Leu Asp Glu Trp Lys Ala Tyr Thr Lys Ala Ala Gly Ile 
        595                 600                 605             


Ile Gln Ser Ser Glu Asp Cys Glu Glu Thr Phe Arg Val Cys Asp Ile 
    610                 615                 620                 


Asp Glu Ser Gly Gln Leu Asp Val Asp Glu Met Thr Arg Gln His Leu 
625                 630                 635                 640 


Gly Phe Trp Tyr Thr Met Asp Pro Ala Cys Glu Lys Leu Tyr Gly Gly 
                645                 650                 655     


Ala Val Pro 
            


<210>  27
<211>  1959
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  secuencia de nucletidos ADiF

<400>  27
atggtgagca agggcgagga ggtcatcaaa gagttcatgc gcttcaaggt gcgcatggag       60

ggctccatga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag      120

ggcacccaga ccgccaagct gaaggtgacc aagggcggcc ccctgccctt cgcctgggac      180

atcctgtccc cccagttcat gtacggctcc aaggcgtacg tgaagcaccc cgccgacatc      240

cccgattaca agaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc      300

gaggacggcg gtctggtgac cgtgacccag gactcctccc tgcaggacgg cacgctgatc      360

tacaaggtga agatgcgcgg caccaacttc ccccccgacg gccccgtaat gcagaagaag      420

accatgggct gggaggcctc caccgagcgc ctgtaccccc gcgacggcgt gctgaagggc      480

gagatccacc aggccctgaa gctgaaggac ggcggccact acctggtgga gttcaagacc      540

atctacatgg ccaagaagcc cgtgcaactg cccggctact actacgtgga caccaagctg      600

gacatcacct cccacaacga ggactacacc atcgtggaac agtacgagcg ctccgagggc      660

cgccaccacc tgttcctggg gcatggcacc ggcagcaccg gcagcggcag ctccggcacc      720

gcctcctccg aggacaacaa catggccgtc atcaaagagt tcatgcgctt caaggtgcgc      780

atggagggct ccatgaacgg ccacgagttc gagatcgagg gcgagggcga gggccgcccc      840

tacgagggca cccagaccgc caagctgaag gtgaccaagg gcggccccct gcccttcgcc      900

tgggacatcc tgtcccccca gttcatgtac ggctccaagg cgtacgtgaa gcaccccgcc      960

gacatccccg attacaagaa gctgtccttc cccgagggct tcaagtggga gcgcgtgatg     1020

aacttcgagg acggcggtct ggtgaccgtg acccaggact cctccctgca ggacggcacg     1080

ctgatctaca aggtgaagat gcgcggcacc aacttccccc ccgacggccc cgtaatgcag     1140

aagaagacca tgggctggga ggcctccacc gagcgcctgt acccccgcga cggcgtgctg     1200

aagggcgaga tccaccaggc cctgaagctg aaggacggcg gccactacct ggtggagttc     1260

aagaccatct acatggccaa gaagcccgtg caactgcccg gctactacta cgtggacacc     1320

aagctggaca tcacctccca caacgaggac tacaccatcg tggaacagta cgagcgctcc     1380

gagggccgcc accacctgtt cctgtccgga ttcgacaacc caagatggat tggacgacac     1440

aagcatatgt tcaatttcct tgatgtcaac cacaatggaa aaatctctct tgacgagatg     1500

gtctacaagg catctgatat tgtcatcaat aaccttggag caacacctga gcaagccaaa     1560

cgacacaaag atgctgtgga agccttcttc ggaggagctg gaatgaaata tggtgtggaa     1620

actgattggc ctgcatttat tgaaggatgg aaaaaattgg ctactgatga attggagaaa     1680

tacgccaaaa acgaaccaac cctcatccgc atctggggtg atgctttgtt tgatatcgtt     1740

gacaaagatc aaaatggagc tattacactg gatgaatgga aagcatacac caaagctgct     1800

ggtatcatcc aatcatcaga agattgcgag gaaacattca gagtgtgcga tattgatgaa     1860

agtggacaac tcgatgttga tgagatgaca agacagcatc tgggattttg gtacaccatg     1920

gatcctgctt gcgaaaagct ctacggtgga gctgtcccc                            1959


<210>  28
<211>  653
<212>  PRT
<213>  Secuencia Artificial 

<220>
<223>  secuencia de aminocidos ADiF

<400>  28

Met Val Ser Lys Gly Glu Glu Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      


Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              


Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  


Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile 
65                  70                  75                  80  


Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      


Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln Asp Ser 
            100                 105                 110         


Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg Gly Thr 
        115                 120                 125             


Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 


Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 


Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu Val 
                165                 170                 175     


Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly 
            180                 185                 190         


Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             


Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His His Leu 
    210                 215                 220                 


Phe Leu Gly His Gly Thr Gly Ser Thr Gly Ser Gly Ser Ser Gly Thr 
225                 230                 235                 240 


Ala Ser Ser Glu Asp Asn Asn Met Ala Val Ile Lys Glu Phe Met Arg 
                245                 250                 255     


Phe Lys Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile 
            260                 265                 270         


Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys 
        275                 280                 285             


Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu 
    290                 295                 300                 


Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala 
305                 310                 315                 320 


Asp Ile Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp 
                325                 330                 335     


Glu Arg Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln 
            340                 345                 350         


Asp Ser Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg 
        355                 360                 365             


Gly Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met 
    370                 375                 380                 


Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu 
385                 390                 395                 400 


Lys Gly Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr 
                405                 410                 415     


Leu Val Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu 
            420                 425                 430         


Pro Gly Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn 
        435                 440                 445             


Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His 
    450                 455                 460                 


His Leu Phe Leu Ser Gly Phe Asp Asn Pro Arg Trp Ile Gly Arg His 
465                 470                 475                 480 


Lys His Met Phe Asn Phe Leu Asp Val Asn His Asn Gly Lys Ile Ser 
                485                 490                 495     


Leu Asp Glu Met Val Tyr Lys Ala Ser Asp Ile Val Ile Asn Asn Leu 
            500                 505                 510         


Gly Ala Thr Pro Glu Gln Ala Lys Arg His Lys Asp Ala Val Glu Ala 
        515                 520                 525             


Phe Phe Gly Gly Ala Gly Met Lys Tyr Gly Val Glu Thr Asp Trp Pro 
    530                 535                 540                 


Ala Phe Ile Glu Gly Trp Lys Lys Leu Ala Thr Asp Glu Leu Glu Lys 
545                 550                 555                 560 


Tyr Ala Lys Asn Glu Pro Thr Leu Ile Arg Ile Trp Gly Asp Ala Leu 
                565                 570                 575     


Phe Asp Ile Val Asp Lys Asp Gln Asn Gly Ala Ile Thr Leu Asp Glu 
            580                 585                 590         


Trp Lys Ala Tyr Thr Lys Ala Ala Gly Ile Ile Gln Ser Ser Glu Asp 
        595                 600                 605             


Cys Glu Glu Thr Phe Arg Val Cys Asp Ile Asp Glu Ser Gly Gln Leu 
    610                 615                 620                 


Asp Val Asp Glu Met Thr Arg Gln His Leu Gly Phe Trp Tyr Thr Met 
625                 630                 635                 640 


Asp Pro Ala Cys Glu Lys Leu Tyr Gly Gly Ala Val Pro
                645                 650                 


<210>  29
<211>  1959
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  secuencia de nucletidos ADN

<400>  29
atggtgagca agggcgagga ggtcatcaaa gagttcatgc gcttcaaggt gcgcatggag       60

ggctccatga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag      120

ggcacccaga ccgccaagct gaaggtgacc aagggcggcc ccctgccctt cgcctgggac      180

atcctgtccc cccagttcat gtacggctcc aaggcgtacg tgaagcaccc cgccgacatc      240

cccgattaca agaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc      300

gaggacggcg gtctggtgac cgtgacccag gactcctccc tgcaggacgg cacgctgatc      360

tacaaggtga agatgcgcgg caccaacttc ccccccgacg gccccgtaat gcagaagaag      420

accatgggct gggaggcctc caccgagcgc ctgtaccccc gcgacggcgt gctgaagggc      480

gagatccacc aggccctgaa gctgaaggac ggcggccact acctggtgga gttcaagacc      540

atctacatgg ccaagaagcc cgtgcaactg cccggctact actacgtgga caccaagctg      600

gacatcacct cccacaacga ggactacacc atcgtggaac agtacgagcg ctccgagggc      660

cgccaccacc tgttcctggg gcatggcacc ggcagcaccg gcagcggcag ctccggcacc      720

gcctcctccg aggacaacaa catggccgtc atcaaagagt tcatgcgctt caaggtgcgc      780

atggagggct ccatgaacgg ccacgagttc gagatcgagg gcgagggcga gggccgcccc      840

tacgagggca cccagaccgc caagctgaag gtgaccaagg gcggccccct gcccttcgcc      900

tgggacatcc tgtcccccca gttcatgtac ggctccaagg cgtacgtgaa gcaccccgcc      960

gacatccccg attacaagaa gctgtccttc cccgagggct tcaagtggga gcgcgtgatg     1020

aacttcgagg acggcggtct ggtgaccgtg acccaggact cctccctgca ggacggcacg     1080

ctgatctaca aggtgaagat gcgcggcacc aacttccccc ccgacggccc cgtaatgcag     1140

aagaagacca tgggctggga ggcctccacc gagcgcctgt acccccgcga cggcgtgctg     1200

aagggcgaga tccaccaggc cctgaagctg aaggacggcg gccactacct ggtggagttc     1260

aagaccatct acatggccaa gaagcccgtg caactgcccg gctactacta cgtggacacc     1320

aagctggaca tcacctccca caacgaggac tacaccatcg tggaacagta cgagcgctcc     1380

gagggccgcc accacctgtt cctgtccgga ttcgacaacc caagatggat tggacgacac     1440

aagcatatgt tcaatttcct tgatgtcgac cacaatggaa aaatctctct tgacgagatg     1500

gtctacaagg catctgatat tgtcatcaat aaccttggag caacacctga gcaagccaaa     1560

cgacacaaag atgctgtgga agccttcttc ggaggagctg gaatgaaata tggtgtggaa     1620

actgattggc ctgcatatat tgaaggatgg aaaaaattgg ctactgatga attggagaaa     1680

tacgccaaaa acgaaccaac cctcatccgc atctggggtg atgctttgtt tgatatcgtt     1740

gacaaagatc aaaatggagc tattacactg gatgaatgga aagcatacac caaagctgct     1800

ggtatcatcc aatcatcaga agattgcgag gaaacattca gagtgtgcga tattgatgaa     1860

agtggacaac tcgatgttga tgagatgaca agacagcatc tgggattttg gtacaccatg     1920

gatcctgctt gcgaaaagct ctacggtgga gctgtcccc                            1959


<210>  30
<211>  653
<212>  PRT
<213>  Secuencia Artificial 

<220>
<223>  secuencia de aminocidos ADN

<400>  30

Met Val Ser Lys Gly Glu Glu Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      


Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              


Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  


Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile 
65                  70                  75                  80  


Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      


Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln Asp Ser 
            100                 105                 110         


Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg Gly Thr 
        115                 120                 125             


Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 


Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 


Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu Val 
                165                 170                 175     


Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly 
            180                 185                 190         


Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             


Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His His Leu 
    210                 215                 220                 


Phe Leu Gly His Gly Thr Gly Ser Thr Gly Ser Gly Ser Ser Gly Thr 
225                 230                 235                 240 


Ala Ser Ser Glu Asp Asn Asn Met Ala Val Ile Lys Glu Phe Met Arg 
                245                 250                 255     


Phe Lys Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile 
            260                 265                 270         


Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys 
        275                 280                 285             


Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu 
    290                 295                 300                 


Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala 
305                 310                 315                 320 


Asp Ile Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp 
                325                 330                 335     


Glu Arg Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln 
            340                 345                 350         


Asp Ser Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg 
        355                 360                 365             


Gly Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met 
    370                 375                 380                 


Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu 
385                 390                 395                 400 


Lys Gly Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr 
                405                 410                 415     


Leu Val Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu 
            420                 425                 430         


Pro Gly Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn 
        435                 440                 445             


Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His 
    450                 455                 460                 


His Leu Phe Leu Ser Gly Phe Asp Asn Pro Arg Trp Ile Gly Arg His 
465                 470                 475                 480 


Lys His Met Phe Asn Phe Leu Asp Val Asp His Asn Gly Lys Ile Ser 
                485                 490                 495     


Leu Asp Glu Met Val Tyr Lys Ala Ser Asp Ile Val Ile Asn Asn Leu 
            500                 505                 510         


Gly Ala Thr Pro Glu Gln Ala Lys Arg His Lys Asp Ala Val Glu Ala 
        515                 520                 525             


Phe Phe Gly Gly Ala Gly Met Lys Tyr Gly Val Glu Thr Asp Trp Pro 
    530                 535                 540                 


Ala Tyr Ile Glu Gly Trp Lys Lys Leu Ala Thr Asp Glu Leu Glu Lys 
545                 550                 555                 560 


Tyr Ala Lys Asn Glu Pro Thr Leu Ile Arg Ile Trp Gly Asp Ala Leu 
                565                 570                 575     


Phe Asp Ile Val Asp Lys Asp Gln Asn Gly Ala Ile Thr Leu Asp Glu 
            580                 585                 590         


Trp Lys Ala Tyr Thr Lys Ala Ala Gly Ile Ile Gln Ser Ser Glu Asp 
        595                 600                 605             


Cys Glu Glu Thr Phe Arg Val Cys Asp Ile Asp Glu Ser Gly Gln Leu 
    610                 615                 620                 


Asp Val Asp Glu Met Thr Arg Gln His Leu Gly Phe Trp Tyr Thr Met 
625                 630                 635                 640 


Asp Pro Ala Cys Glu Lys Leu Tyr Gly Gly Ala Val Pro 
                645                 650                 


<210>  31
<211>  1959
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  secuencia de nucletidos ADQ

<400>  31
atggtgagca agggcgagga ggtcatcaaa gagttcatgc gcttcaaggt gcgcatggag       60

ggctccatga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag      120

ggcacccaga ccgccaagct gaaggtgacc aagggcggcc ccctgccctt cgcctgggac      180

atcctgtccc cccagttcat gtacggctcc aaggcgtacg tgaagcaccc cgccgacatc      240

cccgattaca agaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc      300

gaggacggcg gtctggtgac cgtgacccag gactcctccc tgcaggacgg cacgctgatc      360

tacaaggtga agatgcgcgg caccaacttc ccccccgacg gccccgtaat gcagaagaag      420

accatgggct gggaggcctc caccgagcgc ctgtaccccc gcgacggcgt gctgaagggc      480

gagatccacc aggccctgaa gctgaaggac ggcggccact acctggtgga gttcaagacc      540

atctacatgg ccaagaagcc cgtgcaactg cccggctact actacgtgga caccaagctg      600

gacatcacct cccacaacga ggactacacc atcgtggaac agtacgagcg ctccgagggc      660

cgccaccacc tgttcctggg gcatggcacc ggcagcaccg gcagcggcag ctccggcacc      720

gcctcctccg aggacaacaa catggccgtc atcaaagagt tcatgcgctt caaggtgcgc      780

atggagggct ccatgaacgg ccacgagttc gagatcgagg gcgagggcga gggccgcccc      840

tacgagggca cccagaccgc caagctgaag gtgaccaagg gcggccccct gcccttcgcc      900

tgggacatcc tgtcccccca gttcatgtac ggctccaagg cgtacgtgaa gcaccccgcc      960

gacatccccg attacaagaa gctgtccttc cccgagggct tcaagtggga gcgcgtgatg     1020

aacttcgagg acggcggtct ggtgaccgtg acccaggact cctccctgca ggacggcacg     1080

ctgatctaca aggtgaagat gcgcggcacc aacttccccc ccgacggccc cgtaatgcag     1140

aagaagacca tgggctggga ggcctccacc gagcgcctgt acccccgcga cggcgtgctg     1200

aagggcgaga tccaccaggc cctgaagctg aaggacggcg gccactacct ggtggagttc     1260

aagaccatct acatggccaa gaagcccgtg caactgcccg gctactacta cgtggacacc     1320

aagctggaca tcacctccca caacgaggac tacaccatcg tggaacagta cgagcgctcc     1380

gagggccgcc accacctgtt cctgtccgga ttcgacaacc caagatggat tggacgacac     1440

aagcatatgt tcaatttcct tgatgtcaac cacaatggaa aaatctctct tgacgagatg     1500

gtctacaagg catctgatat tgtcatcaat aaccttggag caacacctga gcaagccaaa     1560

cgacacaaag atgctgtgga agccttcttc ggaggagctg gaatgaaata tggtgtggaa     1620

actgattggc ctgcatatat tgaaggatgg aaaaaattgg ctactgatga attggagaaa     1680

tacgccaaaa acgaaccaac cctcatccgc atctggggtg atgctttgtt tgatatcgtt     1740

gacaaagatc aaaatggagc tattacactg gatgaatgga aagcatacac caaagctgct     1800

ggtatcatcc aatcatcaga agattgcgag gaaacattca gagtgtgcga tattgatgaa     1860

agtggacaac tcgatgttga tgagatgaca agacgacatc tgggattttg gtacaccatg     1920

gatcctgctt gcgaaaagct ctacggtgga gctgtcccc                            1959


<210>  32
<211>  653
<212>  PRT
<213>  Secuencia Artificial 

<220>
<223>  secuencia de aminocidos ADQ

<400>  32

Met Val Ser Lys Gly Glu Glu Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      


Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              


Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  


Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile 
65                  70                  75                  80  


Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      


Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln Asp Ser 
            100                 105                 110         


Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg Gly Thr 
        115                 120                 125             


Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 


Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 


Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu Val 
                165                 170                 175     


Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly 
            180                 185                 190         


Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             


Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His His Leu 
    210                 215                 220                 


Phe Leu Gly His Gly Thr Gly Ser Thr Gly Ser Gly Ser Ser Gly Thr 
225                 230                 235                 240 


Ala Ser Ser Glu Asp Asn Asn Met Ala Val Ile Lys Glu Phe Met Arg 
                245                 250                 255     


Phe Lys Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile 
            260                 265                 270         


Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys 
        275                 280                 285             


Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu 
    290                 295                 300                 


Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala 
305                 310                 315                 320 


Asp Ile Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp 
                325                 330                 335     


Glu Arg Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln 
            340                 345                 350         


Asp Ser Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg 
        355                 360                 365             


Gly Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met 
    370                 375                 380                 


Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu 
385                 390                 395                 400 


Lys Gly Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr 
                405                 410                 415     


Leu Val Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu 
            420                 425                 430         


Pro Gly Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn 
        435                 440                 445             


Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His 
    450                 455                 460                 


His Leu Phe Leu Ser Gly Phe Asp Asn Pro Arg Trp Ile Gly Arg His 
465                 470                 475                 480 


Lys His Met Phe Asn Phe Leu Asp Val Asn His Asn Gly Lys Ile Ser 
                485                 490                 495     


Leu Asp Glu Met Val Tyr Lys Ala Ser Asp Ile Val Ile Asn Asn Leu 
            500                 505                 510         


Gly Ala Thr Pro Glu Gln Ala Lys Arg His Lys Asp Ala Val Glu Ala 
        515                 520                 525             


Phe Phe Gly Gly Ala Gly Met Lys Tyr Gly Val Glu Thr Asp Trp Pro 
    530                 535                 540                 


Ala Tyr Ile Glu Gly Trp Lys Lys Leu Ala Thr Asp Glu Leu Glu Lys 
545                 550                 555                 560 


Tyr Ala Lys Asn Glu Pro Thr Leu Ile Arg Ile Trp Gly Asp Ala Leu 
                565                 570                 575     


Phe Asp Ile Val Asp Lys Asp Gln Asn Gly Ala Ile Thr Leu Asp Glu 
            580                 585                 590         


Trp Lys Ala Tyr Thr Lys Ala Ala Gly Ile Ile Gln Ser Ser Glu Asp 
        595                 600                 605             


Cys Glu Glu Thr Phe Arg Val Cys Asp Ile Asp Glu Ser Gly Gln Leu 
    610                 615                 620                 


Asp Val Asp Glu Met Thr Arg Arg His Leu Gly Phe Trp Tyr Thr Met 
625                 630                 635                 640 


Asp Pro Ala Cys Glu Lys Leu Tyr Gly Gly Ala Val Pro 
                645                 650                 


<210>  33
<211>  1959
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  secuencia de nucletidos ADNQ

<400>  33
atggtgagca agggcgagga ggtcatcaaa gagttcatgc gcttcaaggt gcgcatggag       60

ggctccatga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag      120

ggcacccaga ccgccaagct gaaggtgacc aagggcggcc ccctgccctt cgcctgggac      180

atcctgtccc cccagttcat gtacggctcc aaggcgtacg tgaagcaccc cgccgacatc      240

cccgattaca agaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc      300

gaggacggcg gtctggtgac cgtgacccag gactcctccc tgcaggacgg cacgctgatc      360

tacaaggtga agatgcgcgg caccaacttc ccccccgacg gccccgtaat gcagaagaag      420

accatgggct gggaggcctc caccgagcgc ctgtaccccc gcgacggcgt gctgaagggc      480

gagatccacc aggccctgaa gctgaaggac ggcggccact acctggtgga gttcaagacc      540

atctacatgg ccaagaagcc cgtgcaactg cccggctact actacgtgga caccaagctg      600

gacatcacct cccacaacga ggactacacc atcgtggaac agtacgagcg ctccgagggc      660

cgccaccacc tgttcctggg gcatggcacc ggcagcaccg gcagcggcag ctccggcacc      720

gcctcctccg aggacaacaa catggccgtc atcaaagagt tcatgcgctt caaggtgcgc      780

atggagggct ccatgaacgg ccacgagttc gagatcgagg gcgagggcga gggccgcccc      840

tacgagggca cccagaccgc caagctgaag gtgaccaagg gcggccccct gcccttcgcc      900

tgggacatcc tgtcccccca gttcatgtac ggctccaagg cgtacgtgaa gcaccccgcc      960

gacatccccg attacaagaa gctgtccttc cccgagggct tcaagtggga gcgcgtgatg     1020

aacttcgagg acggcggtct ggtgaccgtg acccaggact cctccctgca ggacggcacg     1080

ctgatctaca aggtgaagat gcgcggcacc aacttccccc ccgacggccc cgtaatgcag     1140

aagaagacca tgggctggga ggcctccacc gagcgcctgt acccccgcga cggcgtgctg     1200

aagggcgaga tccaccaggc cctgaagctg aaggacggcg gccactacct ggtggagttc     1260

aagaccatct acatggccaa gaagcccgtg caactgcccg gctactacta cgtggacacc     1320

aagctggaca tcacctccca caacgaggac tacaccatcg tggaacagta cgagcgctcc     1380

gagggccgcc accacctgtt cctgtccgga ttcgacaacc caagatggat tggacgacac     1440

aagcatatgt tcaatttcct tgatgtcgac cacaatggaa aaatctctct tgacgagatg     1500

gtctacaagg catctgatat tgtcatcaat aaccttggag caacacctga gcaagccaaa     1560

cgacacaaag atgctgtgga agccttcttc ggaggagctg gaatgaaata tggtgtggaa     1620

actgattggc ctgcatatat tgaaggatgg aaaaaattgg ctactgatga attggagaaa     1680

tacgccaaaa acgaaccaac cctcatccgc atctggggtg atgctttgtt tgatatcgtt     1740

gacaaagatc aaaatggagc tattacactg gatgaatgga aagcatacac caaagctgct     1800

ggtatcatcc aatcatcaga agattgcgag gaaacattca gagtgtgcga tattgatgaa     1860

agtggacaac tcgatgttga tgagatgaca agacgacatc tgggattttg gtacaccatg     1920

gatcctgctt gcgaaaagct ctacggtgga gctgtcccc                            1959


<210>  34
<211>  653
<212>  PRT
<213>  Secuencia Artificial 

<220>
<223>  secuencia de aminocidos ADNQ

<400>  34

Met Val Ser Lys Gly Glu Glu Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      


Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              


Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  


Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile 
65                  70                  75                  80  


Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      


Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln Asp Ser 
            100                 105                 110         


Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg Gly Thr 
        115                 120                 125             


Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 


Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 


Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu Val 
                165                 170                 175     


Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly 
            180                 185                 190         


Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             


Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His His Leu 
    210                 215                 220                 


Phe Leu Gly His Gly Thr Gly Ser Thr Gly Ser Gly Ser Ser Gly Thr 
225                 230                 235                 240 


Ala Ser Ser Glu Asp Asn Asn Met Ala Val Ile Lys Glu Phe Met Arg 
                245                 250                 255     


Phe Lys Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile 
            260                 265                 270         


Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys 
        275                 280                 285             


Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu 
    290                 295                 300                 


Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala 
305                 310                 315                 320 


Asp Ile Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp 
                325                 330                 335     


Glu Arg Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln 
            340                 345                 350         


Asp Ser Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg 
        355                 360                 365             


Gly Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met 
    370                 375                 380                 


Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu 
385                 390                 395                 400 


Lys Gly Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr 
                405                 410                 415     


Leu Val Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu 
            420                 425                 430         


Pro Gly Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn 
        435                 440                 445             


Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His 
    450                 455                 460                 


His Leu Phe Leu Ser Gly Phe Asp Asn Pro Arg Trp Ile Gly Arg His 
465                 470                 475                 480 


Lys His Met Phe Asn Phe Leu Asp Val Asp His Asn Gly Lys Ile Ser 
                485                 490                 495     


Leu Asp Glu Met Val Tyr Lys Ala Ser Asp Ile Val Ile Asn Asn Leu 
            500                 505                 510         


Gly Ala Thr Pro Glu Gln Ala Lys Arg His Lys Asp Ala Val Glu Ala 
        515                 520                 525             


Phe Phe Gly Gly Ala Gly Met Lys Tyr Gly Val Glu Thr Asp Trp Pro 
    530                 535                 540                 


Ala Tyr Ile Glu Gly Trp Lys Lys Leu Ala Thr Asp Glu Leu Glu Lys 
545                 550                 555                 560 


Tyr Ala Lys Asn Glu Pro Thr Leu Ile Arg Ile Trp Gly Asp Ala Leu 
                565                 570                 575     


Phe Asp Ile Val Asp Lys Asp Gln Asn Gly Ala Ile Thr Leu Asp Glu 
            580                 585                 590         


Trp Lys Ala Tyr Thr Lys Ala Ala Gly Ile Ile Gln Ser Ser Glu Asp 
        595                 600                 605             


Cys Glu Glu Thr Phe Arg Val Cys Asp Ile Asp Glu Ser Gly Gln Leu 
    610                 615                 620                 


Asp Val Asp Glu Met Thr Arg Arg His Leu Gly Phe Trp Tyr Thr Met 
625                 630                 635                 640 


Asp Pro Ala Cys Glu Lys Leu Tyr Gly Gly Ala Val Pro 
                645                 650                 


<210>  35
<211>  1344
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  secuencia de nucletidos CitA

<400>  35
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccttcggcta cggcctgatg tgcttcgccc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagct accagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagggt      720

accgagctgt acaagtccgg cgggagcgga tccggcggcc agtccggact cagatctgtc      780

aaacttacat cagacttcga caacccaaga tggattggac gacacaagca tatgttcaat      840

ttccttgatg tcaaccacaa tggaaaaatc tctcttgacg agatggtcta caaggcatct      900

gatattgtca tcaataacct tggagcaaca cctgagcaag ccaaacgaca caaagatgct      960

gtggaagccc tcttcggagg agctggaatg aaatatggtg tggaaactga ttggcctgca     1020

tatattgaag gatggaaaaa attggctact gatgaattgg agaaatacgc caaaaacgaa     1080

ccaaccctca tccgcatctg gggtgatgct ttgtttgata tcgttgacaa agatcaaaat     1140

ggagccatta cactggatga atggaaagca tacaccaaag ctgctggtat catccaatca     1200

tcagaagatt gcgaggaaac attcagagtg tgcgatattg atgaaagtgg acaactcgat     1260

gttgatgaga tgacaagaca gcatctggga ttttggtaca ccatggatcc tgcttgcgaa     1320

aagctctacg gtggagctgt cccc                                            1344


<210>  36
<211>  448
<212>  PRT
<213>  Secuencia Artificial 

<220>
<223>  secuencia de aminocidos CitA

<400>  36

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Phe Gly Tyr Gly Leu Met Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Thr Glu Leu Tyr Lys Ser Gly Gly Ser Gly Ser Gly Gly Gln Ser Gly 
                245                 250                 255     


Leu Arg Ser Val Lys Leu Thr Ser Asp Phe Asp Asn Pro Arg Trp Ile 
            260                 265                 270         


Gly Arg His Lys His Met Phe Asn Phe Leu Asp Val Asn His Asn Gly 
        275                 280                 285             


Lys Ile Ser Leu Asp Glu Met Val Tyr Lys Ala Ser Asp Ile Val Ile 
    290                 295                 300                 


Asn Asn Leu Gly Ala Thr Pro Glu Gln Ala Lys Arg His Lys Asp Ala 
305                 310                 315                 320 


Val Glu Ala Leu Phe Gly Gly Ala Gly Met Lys Tyr Gly Val Glu Thr 
                325                 330                 335     


Asp Trp Pro Ala Tyr Ile Glu Gly Trp Lys Lys Leu Ala Thr Asp Glu 
            340                 345                 350         


Leu Glu Lys Tyr Ala Lys Asn Glu Pro Thr Leu Ile Arg Ile Trp Gly 
        355                 360                 365             


Asp Ala Leu Phe Asp Ile Val Asp Lys Asp Gln Asn Gly Ala Ile Thr 
    370                 375                 380                 


Leu Asp Glu Trp Lys Ala Tyr Thr Lys Ala Ala Gly Ile Ile Gln Ser 
385                 390                 395                 400 


Ser Glu Asp Cys Glu Glu Thr Phe Arg Val Cys Asp Ile Asp Glu Ser 
                405                 410                 415     


Gly Gln Leu Asp Val Asp Glu Met Thr Arg Gln His Leu Gly Phe Trp 
            420                 425                 430         


Tyr Thr Met Asp Pro Ala Cys Glu Lys Leu Tyr Gly Gly Ala Val Pro 
        435                 440                 445             



<210>  37
<211>  2058
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  secuencia de nucletidos mitoAD1

<400>  37
atgtccgtcc tgacgccgct gctgctgcgg ggcttgacag gctcggcccg gcggctccca       60

gtgccgcgcg ccaagatcca ttcgttgaag cttgccacca tggtgagcaa gggcgaggag      120

gtcatcaaag agttcatgcg cttcaaggtg cgcatggagg gctccatgaa cggccacgag      180

ttcgagatcg agggcgaggg cgagggccgc ccctacgagg gcacccagac cgccaagctg      240

aaggtgacca agggcggccc cctgcccttc gcctgggaca tcctgtcccc ccagttcatg      300

tacggctcca aggcgtacgt gaagcacccc gccgacatcc ccgattacaa gaagctgtcc      360

ttccccgagg gcttcaagtg ggagcgcgtg atgaacttcg aggacggcgg tctggtgacc      420

gtgacccagg actcctccct gcaggacggc acgctgatct acaaggtgaa gatgcgcggc      480

accaacttcc cccccgacgg ccccgtaatg cagaagaaga ccatgggctg ggaggcctcc      540

accgagcgcc tgtacccccg cgacggcgtg ctgaagggcg agatccacca ggccctgaag      600

ctgaaggacg gcggccacta cctggtggag ttcaagacca tctacatggc caagaagccc      660

gtgcaactgc ccggctacta ctacgtggac accaagctgg acatcacctc ccacaacgag      720

gactacacca tcgtggaaca gtacgagcgc tccgagggcc gccaccacct gttcctgggg      780

catggcaccg gcagcaccgg cagcggcagc tccggcaccg cctcctccga ggacaacaac      840

atggccgtca tcaaagagtt catgcgcttc aaggtgcgca tggagggctc catgaacggc      900

cacgagttcg agatcgaggg cgagggcgag ggccgcccct acgagggcac ccagaccgcc      960

aagctgaagg tgaccaaggg cggccccctg cccttcgcct gggacatcct gtccccccag     1020

ttcatgtacg gctccaaggc gtacgtgaag caccccgccg acatccccga ttacaagaag     1080

ctgtccttcc ccgagggctt caagtgggag cgcgtgatga acttcgagga cggcggtctg     1140

gtgaccgtga cccaggactc ctccctgcag gacggcacgc tgatctacaa ggtgaagatg     1200

cgcggcacca acttcccccc cgacggcccc gtaatgcaga agaagaccat gggctgggag     1260

gcctccaccg agcgcctgta cccccgcgac ggcgtgctga agggcgagat ccaccaggcc     1320

ctgaagctga aggacggcgg ccactacctg gtggagttca agaccatcta catggccaag     1380

aagcccgtgc aactgcccgg ctactactac gtggacacca agctggacat cacctcccac     1440

aacgaggact acaccatcgt ggaacagtac gagcgctccg agggccgcca ccacctgttc     1500

ctgtccggat tcgacaaccc aagatggatt ggacgacaca agcatatgtt caatttcctt     1560

gatgtcaacc acaatggaaa aatctctctt gacgagatgg tctacaaggc atctgatatt     1620

gtcatcaata accttggagc aacacctgag caagccaaac gacacaaaga tgctgtggaa     1680

gccttcttcg gaggagctgg aatgaaatat ggtgtggaaa ctgattggcc tgcatatatt     1740

gaaggatgga aaaaattggc tactgatgaa ttggagaaat acgccaaaaa cgaaccaacc     1800

ctcatccgca tctggggtga tgctttgttt gatatcgttg acaaagatca aaatggagct     1860

attacactgg atgaatggaa agcatacacc aaagctgctg gtatcatcca atcatcagaa     1920

gattgcgagg aaacattcag agtgtgcgat attgatgaaa gtggacaact cgatgttgat     1980

gagatgacaa gacagcatct gggattttgg tacaccatgg atcctgcttg cgaaaagctc     2040

tacggtggag ctgtcccc                                                   2058


<210>  38
<211>  686
<212>  PRT
<213>  Secuencia Artificial 

<220>
<223>  secuencia de aminocidos mitoAD1

<400>  38

Met Ser Val Leu Thr Pro Leu Leu Leu Arg Gly Leu Thr Gly Ser Ala 
1               5                   10                  15      


Arg Arg Leu Pro Val Pro Arg Ala Lys Ile His Ser Leu Lys Leu Ala 
            20                  25                  30          


Thr Met Val Ser Lys Gly Glu Glu Val Ile Lys Glu Phe Met Arg Phe 
        35                  40                  45              


Lys Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu 
    50                  55                  60                  


Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu 
65                  70                  75                  80  


Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser 
                85                  90                  95      


Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp 
            100                 105                 110         


Ile Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu 
        115                 120                 125             


Arg Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln Asp 
    130                 135                 140                 


Ser Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg Gly 
145                 150                 155                 160 


Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly 
                165                 170                 175     


Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys 
            180                 185                 190         


Gly Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu 
        195                 200                 205             


Val Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro 
    210                 215                 220                 


Gly Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn Glu 
225                 230                 235                 240 


Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His His 
                245                 250                 255     


Leu Phe Leu Gly His Gly Thr Gly Ser Thr Gly Ser Gly Ser Ser Gly 
            260                 265                 270         


Thr Ala Ser Ser Glu Asp Asn Asn Met Ala Val Ile Lys Glu Phe Met 
        275                 280                 285             


Arg Phe Lys Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu 
    290                 295                 300                 


Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala 
305                 310                 315                 320 


Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile 
                325                 330                 335     


Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro 
            340                 345                 350         


Ala Asp Ile Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys 
        355                 360                 365             


Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr 
    370                 375                 380                 


Gln Asp Ser Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met 
385                 390                 395                 400 


Arg Gly Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr 
                405                 410                 415     


Met Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val 
            420                 425                 430         


Leu Lys Gly Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His 
        435                 440                 445             


Tyr Leu Val Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln 
    450                 455                 460                 


Leu Pro Gly Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His 
465                 470                 475                 480 


Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg 
                485                 490                 495     


His His Leu Phe Leu Ser Gly Phe Asp Asn Pro Arg Trp Ile Gly Arg 
            500                 505                 510         


His Lys His Met Phe Asn Phe Leu Asp Val Asn His Asn Gly Lys Ile 
        515                 520                 525             


Ser Leu Asp Glu Met Val Tyr Lys Ala Ser Asp Ile Val Ile Asn Asn 
    530                 535                 540                 


Leu Gly Ala Thr Pro Glu Gln Ala Lys Arg His Lys Asp Ala Val Glu 
545                 550                 555                 560 


Ala Phe Phe Gly Gly Ala Gly Met Lys Tyr Gly Val Glu Thr Asp Trp 
                565                 570                 575     


Pro Ala Tyr Ile Glu Gly Trp Lys Lys Leu Ala Thr Asp Glu Leu Glu 
            580                 585                 590         


Lys Tyr Ala Lys Asn Glu Pro Thr Leu Ile Arg Ile Trp Gly Asp Ala 
        595                 600                 605             


Leu Phe Asp Ile Val Asp Lys Asp Gln Asn Gly Ala Ile Thr Leu Asp 
    610                 615                 620                 


Glu Trp Lys Ala Tyr Thr Lys Ala Ala Gly Ile Ile Gln Ser Ser Glu 
625                 630                 635                 640 


Asp Cys Glu Glu Thr Phe Arg Val Cys Asp Ile Asp Glu Ser Gly Gln 
                645                 650                 655     


Leu Asp Val Asp Glu Met Thr Arg Gln His Leu Gly Phe Trp Tyr Thr 
            660                 665                 670         


Met Asp Pro Ala Cys Glu Lys Leu Tyr Gly Gly Ala Val Pro 
        675                 680                 685         


<210>  39
<211>  2058
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  secuencia de nucletidos mitoADNQ

<400>  39
atgtccgtcc tgacgccgct gctgctgcgg ggcttgacag gctcggcccg gcggctccca       60

gtgccgcgcg ccaagatcca ttcgttgaag cttgccacca tggtgagcaa gggcgaggag      120

gtcatcaaag agttcatgcg cttcaaggtg cgcatggagg gctccatgaa cggccacgag      180

ttcgagatcg agggcgaggg cgagggccgc ccctacgagg gcacccagac cgccaagctg      240

aaggtgacca agggcggccc cctgcccttc gcctgggaca tcctgtcccc ccagttcatg      300

tacggctcca aggcgtacgt gaagcacccc gccgacatcc ccgattacaa gaagctgtcc      360

ttccccgagg gcttcaagtg ggagcgcgtg atgaacttcg aggacggcgg tctggtgacc      420

gtgacccagg actcctccct gcaggacggc acgctgatct acaaggtgaa gatgcgcggc      480

accaacttcc cccccgacgg ccccgtaatg cagaagaaga ccatgggctg ggaggcctcc      540

accgagcgcc tgtacccccg cgacggcgtg ctgaagggcg agatccacca ggccctgaag      600

ctgaaggacg gcggccacta cctggtggag ttcaagacca tctacatggc caagaagccc      660

gtgcaactgc ccggctacta ctacgtggac accaagctgg acatcacctc ccacaacgag      720

gactacacca tcgtggaaca gtacgagcgc tccgagggcc gccaccacct gttcctgggg      780

catggcaccg gcagcaccgg cagcggcagc tccggcaccg cctcctccga ggacaacaac      840

atggccgtca tcaaagagtt catgcgcttc aaggtgcgca tggagggctc catgaacggc      900

cacgagttcg agatcgaggg cgagggcgag ggccgcccct acgagggcac ccagaccgcc      960

aagctgaagg tgaccaaggg cggccccctg cccttcgcct gggacatcct gtccccccag     1020

ttcatgtacg gctccaaggc gtacgtgaag caccccgccg acatccccga ttacaagaag     1080

ctgtccttcc ccgagggctt caagtgggag cgcgtgatga acttcgagga cggcggtctg     1140

gtgaccgtga cccaggactc ctccctgcag gacggcacgc tgatctacaa ggtgaagatg     1200

cgcggcacca acttcccccc cgacggcccc gtaatgcaga agaagaccat gggctgggag     1260

gcctccaccg agcgcctgta cccccgcgac ggcgtgctga agggcgagat ccaccaggcc     1320

ctgaagctga aggacggcgg ccactacctg gtggagttca agaccatcta catggccaag     1380

aagcccgtgc aactgcccgg ctactactac gtggacacca agctggacat cacctcccac     1440

aacgaggact acaccatcgt ggaacagtac gagcgctccg agggccgcca ccacctgttc     1500

ctgtccggat tcgacaaccc aagatggatt ggacgacaca agcatatgtt caatttcctt     1560

gatgtcgacc acaatggaaa aatctctctt gacgagatgg tctacaaggc atctgatatt     1620

gtcatcaata accttggagc aacacctgag caagccaaac gacacaaaga tgctgtggaa     1680

gccttcttcg gaggagctgg aatgaaatat ggtgtggaaa ctgattggcc tgcatatatt     1740

gaaggatgga aaaaattggc tactgatgaa ttggagaaat acgccaaaaa cgaaccaacc     1800

ctcatccgca tctggggtga tgctttgttt gatatcgttg acaaagatca aaatggagct     1860

attacactgg atgaatggaa agcatacacc aaagctgctg gtatcatcca atcatcagaa     1920

gattgcgagg aaacattcag agtgtgcgat attgatgaaa gtggacaact cgatgttgat     1980

gagatgacaa gacgacatct gggattttgg tacaccatgg atcctgcttg cgaaaagctc     2040

tacggtggag ctgtcccc                                                   2058


<210>  40
<211>  686
<212>  PRT
<213>  Secuencia Artificial 

<220>
<223>  secuencia de aminocidos mitoADNQ

<400>  40

Met Ser Val Leu Thr Pro Leu Leu Leu Arg Gly Leu Thr Gly Ser Ala 
1               5                   10                  15      


Arg Arg Leu Pro Val Pro Arg Ala Lys Ile His Ser Leu Lys Leu Ala 
            20                  25                  30          


Thr Met Val Ser Lys Gly Glu Glu Val Ile Lys Glu Phe Met Arg Phe 
        35                  40                  45              


Lys Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu 
    50                  55                  60                  


Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu 
65                  70                  75                  80  


Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser 
                85                  90                  95      


Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp 
            100                 105                 110         


Ile Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu 
        115                 120                 125             


Arg Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln Asp 
    130                 135                 140                 


Ser Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg Gly 
145                 150                 155                 160 


Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly 
                165                 170                 175     


Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys 
            180                 185                 190         


Gly Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu 
        195                 200                 205             


Val Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro 
    210                 215                 220                 


Gly Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn Glu 
225                 230                 235                 240 


Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His His 
                245                 250                 255     


Leu Phe Leu Gly His Gly Thr Gly Ser Thr Gly Ser Gly Ser Ser Gly 
            260                 265                 270         


Thr Ala Ser Ser Glu Asp Asn Asn Met Ala Val Ile Lys Glu Phe Met 
        275                 280                 285             


Arg Phe Lys Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu 
    290                 295                 300                 


Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala 
305                 310                 315                 320 


Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile 
                325                 330                 335     


Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro 
            340                 345                 350         


Ala Asp Ile Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys 
        355                 360                 365             


Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr 
    370                 375                 380                 


Gln Asp Ser Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met 
385                 390                 395                 400 


Arg Gly Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr 
                405                 410                 415     


Met Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val 
            420                 425                 430         


Leu Lys Gly Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His 
        435                 440                 445             


Tyr Leu Val Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln 
    450                 455                 460                 


Leu Pro Gly Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His 
465                 470                 475                 480 


Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg 
                485                 490                 495     


His His Leu Phe Leu Ser Gly Phe Asp Asn Pro Arg Trp Ile Gly Arg 
            500                 505                 510         


His Lys His Met Phe Asn Phe Leu Asp Val Asp His Asn Gly Lys Ile 
        515                 520                 525             


Ser Leu Asp Glu Met Val Tyr Lys Ala Ser Asp Ile Val Ile Asn Asn 
    530                 535                 540                 


Leu Gly Ala Thr Pro Glu Gln Ala Lys Arg His Lys Asp Ala Val Glu 
545                 550                 555                 560 


Ala Phe Phe Gly Gly Ala Gly Met Lys Tyr Gly Val Glu Thr Asp Trp 
                565                 570                 575     


Pro Ala Tyr Ile Glu Gly Trp Lys Lys Leu Ala Thr Asp Glu Leu Glu 
            580                 585                 590         


Lys Tyr Ala Lys Asn Glu Pro Thr Leu Ile Arg Ile Trp Gly Asp Ala 
        595                 600                 605             


Leu Phe Asp Ile Val Asp Lys Asp Gln Asn Gly Ala Ile Thr Leu Asp 
    610                 615                 620                 


Glu Trp Lys Ala Tyr Thr Lys Ala Ala Gly Ile Ile Gln Ser Ser Glu 
625                 630                 635                 640 


Asp Cys Glu Glu Thr Phe Arg Val Cys Asp Ile Asp Glu Ser Gly Gln 
                645                 650                 655     


Leu Asp Val Asp Glu Met Thr Arg Arg His Leu Gly Phe Trp Tyr Thr 
            660                 665                 670         


Met Asp Pro Ala Cys Glu Lys Leu Tyr Gly Gly Ala Val Pro 
        675                 680                 685         


<210>  41
<211>  11
<212>  PRT
<213>  Secuencia Artificial 

<220>
<223>  polipptido espaciador 1

<400>  41

Ser Gly Gly Ser Gly Ser Ser Gly Leu Arg Ser 
1               5                   10      


<210>  42
<211>  8
<212>  PRT
<213>  Secuencia Artificial 

<220>
<223>  polipptido espaciador 2

<400>  42

Ser Gly Gly Ser Gly Ser Ser Gly 
1               5               


<210>  43
<211>  73
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  22aa-L-1, oligonucletido sentido de un enlazador de 22 
       aminoacidos para generar el clon b12

<400>  43
ccggggtggc agtggaagtg gtcaaagtgg ttccggtagt ggaggccaga gtggtagtgg       60

aagtggccaa tcc                                                          73


<210>  44
<211>  72
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  22aa-L-2, oligonucletido anti-sentido de un enlazador de 22 
       aminoacidos para generar el clon b12

<400>  44
caccgtcacc ttcaccagtt tcaccaaggc catcacctcc ggtctcacca tcaccttcac       60

cggttagggg cc                                                           72


<210>  45
<211>  43
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  13aa-L-1, oligonucletido sentido de un enlazador de 13 
       aminoacidos para construir el clon a1

<400>  45
ccggggtagt ggaggccaga gtggtagtgg aagtggccaa tcc                         43


<210>  46
<211>  43
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  13aa-L-2, oligonucletido anti-sentido de un enlazador de 13 
       aminoacidos para construir el clon a1

<400>  46
ccatcacctc cggtctcacc atcaccttca ccggttaggg gcc                         43


<210>  47
<211>  18
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  6aa-L-1, oligonucletido sentido de un enlazador de 6 aminoacidos
       para generar el clon ADiFL

<400>  47
ccggcggcag cggtagct                                                     18


<210>  48
<211>  18
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  6aa-L-2, oligonucletido anti-sentido de un enlazador de 6 
       aminoacidos para generar el clon ADiFL

<400>  48
gccgtcgcca tcgaggcc                                                     18


<210>  49
<211>  30
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  YG-SG, oligonucletido mutagnico sentido y fosforilado  en el 
       1er nucletido, para generar clones A3, AW, AE, AD1, Alfa

<400>  49
ctgttcctgt ccggaatgga cgagctgtac                                        30


<210>  50
<211>  32
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  LF-SG-1, oligonucletido mutagnico en sentido y fosforilado en 
       el 1er nucletido,  para construir clones B2 y BW (1 ronda de 
       mutagnesis)

<400>  50
ccgccaccac ttgggcctgt acggcatgga cg                                     32


<210>  51
<211>  32
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  LF-SG-2, oligonucletido mutagnico sentido y fosforilado  en el 
       1er nucletido, para construir clones B2 y BW (2 ronda de 
       mutagnesis)

<400>  51
ccgccaccac tccggactgt acggcatgga cg                                     32


<210>  52
<211>  38
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  DN-SG-1, oligonucletido mutagnico sentido y fosforilado  en el 
       1er nucletido, para generar clones A3 y B2 (1 ronda de 
       mutagnesis)

<400>  52
cttacatcag acttcgccag accaagatgg attggacg                               38


<210>  53
<211>  35
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  DN-SG-2, oligonucletido mutagnico sentido y fosforilado  en el 
       1er nucletido para generar clones A3 y B2 (2 ronda de 
       mutagnesis)

<400>  53
tacatcagac ttctccggac caagatggat tggac                                  35


<210>  54
<211>  40
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  SD-SG, oligonucletido mutagnico sentido y fosforilado en el 1er
       nucletido, para construir el clon AD1

<400>  54
gatctgtcaa acttacatcc ggattcgaca acccaagatg                             40


<210>  55
<211>  40
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  SV-SG, oligonucletido mutagnico sentido y fosforilado en el 1er
       nucletido, para construir el clon AE

<400>  55
cagtccggac tcagatccgg aaaacttaca tcagacttcg                             40


<210>  56
<211>  37
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  G-D,  oligonucletido mutagnico sentido y fosforilado  en el 1er
       nucletido, para construir el clon Alfa

<400>  56
ccacctgttc ctgtccgact tcgacaaccc aagatgg                                37


<210>  57
<211>  39
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  F224L, oligonucletido mutagnico sentido y fosforilado  en el 
       1er nucletido para generar el clon Alfa

<400>  57
gagggccgcc accacctgct gctgtccgga ttcgacaac                              39


<210>  58
<211>  47
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  N26D, oligonucletido mutagnico sentido y fosforilado en el 1er 
       nucletido,  para generar el clon ADN y ADNQ

<400>  58
gttcaatttc cttgatgtcg accacaatgg aaaaatctct cttgacg                     47


<210>  59
<211>  45
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  Y82F, oligonucletido mutagnico sentido y fosforilado  en el 1er
       nucletido, para generar el clon ADiF y ADiFL

<400>  59
gtggaaactg attggcctgc atttattgaa ggatggaaaa aattg                       45


<210>  60
<211>  45
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  Q168R, oligonucletido mutagnico sentido y fosforilado en el 1er
       nucletido, para generar el clon ADQ y ADNQ

<400>  60
gatgttgatg agatgacaag acgacatctg ggattttggt acacc                       45


<210>  61
<211>  33
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  HIII-out, oligonucletido mutagnico sentido y fosforilado  en el
       1er nucletido, para la eliminacin del 1er sitio HindIII en 
       mitotdTA

<400>  61
ctatagggag acccaagcta ggtaccgagc tcg                                    33


<210>  62
<211>  2055
<212>  DNA
<213>  Secuencia Artificial 

<220>
<223>  secuencia de nucletidos tdTomato-Aeq, tdTA

<400>  62
atggtgagca agggcgagga ggtcatcaaa gagttcatgc gcttcaaggt gcgcatggag       60

ggctccatga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag      120

ggcacccaga ccgccaagct gaaggtgacc aagggcggcc ccctgccctt cgcctgggac      180

atcctgtccc cccagttcat gtacggctcc aaggcgtacg tgaagcaccc cgccgacatc      240

cccgattaca agaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc      300

gaggacggcg gtctggtgac cgtgacccag gactcctccc tgcaggacgg cacgctgatc      360

tacaaggtga agatgcgcgg caccaacttc ccccccgacg gccccgtaat gcagaagaag      420

accatgggct gggaggcctc caccgagcgc ctgtaccccc gcgacggcgt gctgaagggc      480

gagatccacc aggccctgaa gctgaaggac ggcggccact acctggtgga gttcaagacc      540

atctacatgg ccaagaagcc cgtgcaactg cccggctact actacgtgga caccaagctg      600

gacatcacct cccacaacga ggactacacc atcgtggaac agtacgagcg ctccgagggc      660

cgccaccacc tgttcctggg gcatggcacc ggcagcaccg gcagcggcag ctccggcacc      720

gcctcctccg aggacaacaa catggccgtc atcaaagagt tcatgcgctt caaggtgcgc      780

atggagggct ccatgaacgg ccacgagttc gagatcgagg gcgagggcga gggccgcccc      840

tacgagggca cccagaccgc caagctgaag gtgaccaagg gcggccccct gcccttcgcc      900

tgggacatcc tgtcccccca gttcatgtac ggctccaagg cgtacgtgaa gcaccccgcc      960

gacatccccg attacaagaa gctgtccttc cccgagggct tcaagtggga gcgcgtgatg     1020

aacttcgagg acggcggtct ggtgaccgtg acccaggact cctccctgca ggacggcacg     1080

ctgatctaca aggtgaagat gcgcggcacc aacttccccc ccgacggccc cgtaatgcag     1140

aagaagacca tgggctggga ggcctccacc gagcgcctgt acccccgcga cggcgtgctg     1200

aagggcgaga tccaccaggc cctgaagctg aaggacggcg gccactacct ggtggagttc     1260

aagaccatct acatggccaa gaagcccgtg caactgcccg gctactacta cgtggacacc     1320

aagctggaca tcacctccca caacgaggac tacaccatcg tggaacagta cgagcgctcc     1380

gagggccgcc accacctgtt cctgtacggc atggacgagc tgtacaaggg taccgagctg     1440

tacaagtccg gcgggagcgg atccggcggc cagtccggac tcagatctgt caaacttaca     1500

tcagacttcg acaacccaag atggattgga cgacacaagc atatgttcaa tttccttgat     1560

gtcaaccaca atggaaaaat ctctcttgac gagatggtct acaaggcatc tgatattgtc     1620

atcaataacc ttggagcaac acctgagcaa gccaaacgac acaaagatgc tgtggaagcc     1680

ttcttcggag gagctggaat gaaatatggt gtggaaactg attggcctgc atatattgaa     1740

ggatggaaaa aattggctac tgatgaattg gagaaatacg ccaaaaacga accaaccctc     1800

atccgcatct ggggtgatgc tttgtttgat atcgttgaca aagatcaaaa tggagctatt     1860

acactggatg aatggaaagc atacaccaaa gctgctggta tcatccaatc atcagaagat     1920

tgcgaggaaa cattcagagt gtgcgatatt gatgaaagtg gacaactcga tgttgatgag     1980

atgacaagac agcatctggg attttggtac accatggatc ctgcttgcga aaagctctac     2040

ggtggagctg tcccc                                                      2055


<210>  63
<211>  685
<212>  PRT
<213>  Secuencia Artificial 

<220>
<223>  secuencia de aminocidos tdTomato-Aeq, tdTA

<400>  63

Met Val Ser Lys Gly Glu Glu Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      


Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              


Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  


Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile 
65                  70                  75                  80  


Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      


Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln Asp Ser 
            100                 105                 110         


Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg Gly Thr 
        115                 120                 125             


Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 


Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 


Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu Val 
                165                 170                 175     


Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly 
            180                 185                 190         


Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             


Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His His Leu 
    210                 215                 220                 


Phe Leu Gly His Gly Thr Gly Ser Thr Gly Ser Gly Ser Ser Gly Thr 
225                 230                 235                 240 


Ala Ser Ser Glu Asp Asn Asn Met Ala Val Ile Lys Glu Phe Met Arg 
                245                 250                 255     


Phe Lys Val Arg Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile 
            260                 265                 270         


Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys 
        275                 280                 285             


Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu 
    290                 295                 300                 


Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala 
305                 310                 315                 320 


Asp Ile Pro Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp 
                325                 330                 335     


Glu Arg Val Met Asn Phe Glu Asp Gly Gly Leu Val Thr Val Thr Gln 
            340                 345                 350         


Asp Ser Ser Leu Gln Asp Gly Thr Leu Ile Tyr Lys Val Lys Met Arg 
        355                 360                 365             


Gly Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met 
    370                 375                 380                 


Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu 
385                 390                 395                 400 


Lys Gly Glu Ile His Gln Ala Leu Lys Leu Lys Asp Gly Gly His Tyr 
                405                 410                 415     


Leu Val Glu Phe Lys Thr Ile Tyr Met Ala Lys Lys Pro Val Gln Leu 
            420                 425                 430         


Pro Gly Tyr Tyr Tyr Val Asp Thr Lys Leu Asp Ile Thr Ser His Asn 
        435                 440                 445             


Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His 
    450                 455                 460                 


His Leu Phe Leu Tyr Gly Met Asp Glu Leu Tyr Lys Gly Thr Glu Leu 
465                 470                 475                 480 


Tyr Lys Ser Gly Gly Ser Gly Ser Gly Gly Gln Ser Gly Leu Arg Ser 
                485                 490                 495     


Val Lys Leu Thr Ser Asp Phe Asp Asn Pro Arg Trp Ile Gly Arg His 
            500                 505                 510         


Lys His Met Phe Asn Phe Leu Asp Val Asn His Asn Gly Lys Ile Ser 
        515                 520                 525             


Leu Asp Glu Met Val Tyr Lys Ala Ser Asp Ile Val Ile Asn Asn Leu 
    530                 535                 540                 


Gly Ala Thr Pro Glu Gln Ala Lys Arg His Lys Asp Ala Val Glu Ala 
545                 550                 555                 560 


Phe Phe Gly Gly Ala Gly Met Lys Tyr Gly Val Glu Thr Asp Trp Pro 
                565                 570                 575     


Ala Tyr Ile Glu Gly Trp Lys Lys Leu Ala Thr Asp Glu Leu Glu Lys 
            580                 585                 590         


Tyr Ala Lys Asn Glu Pro Thr Leu Ile Arg Ile Trp Gly Asp Ala Leu 
        595                 600                 605             


Phe Asp Ile Val Asp Lys Asp Gln Asn Gly Ala Ile Thr Leu Asp Glu 
    610                 615                 620                 


Trp Lys Ala Tyr Thr Lys Ala Ala Gly Ile Ile Gln Ser Ser Glu Asp 
625                 630                 635                 640 


Cys Glu Glu Thr Phe Arg Val Cys Asp Ile Asp Glu Ser Gly Gln Leu 
                645                 650                 655     


Asp Val Asp Glu Met Thr Arg Gln His Leu Gly Phe Trp Tyr Thr Met 
            660                 665                 670         


Asp Pro Ala Cys Glu Lys Leu Tyr Gly Gly Ala Val Pro 
        675                 680                 685     


