                         SEQUENCE LISTING

<110>  Sanofi Pasteur
 
<120>  Vaccine Compositions

<130>  P39478WO

<150>  EP12305912.3
<151>  2012-07-25

<150>  EP12305907.3
<151>  2012-07-24

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  1983
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clinical trial circulating strain

<400>  1
ttccatctaa ccacacgcaa cggagaacca cacatgatcg tcggtataca ggagaaaggg       60

aaaagtcttc tgttcaaaac agaggatggt gtgaacatgt gcaccctcat ggctatggac      120

cttggtgaat tgtgtgaaga cacaatcacg tacaagtgtc ctcttctcag gcagaatgag      180

ccagaagaca tagactgttg gtgcaactcc acgtccacgt gggtaaccta tgggacctgt      240

accactacgg gagaacatag gagagaaaaa agatcagtgg cactcgttcc acatgtggga      300

atgggactgg agacgcgaac cgaaacatgg atgtcatcag aaggggcttg gaaacatgcc      360

cagagaattg aaacttggat cctgagacat ccaggcttca ccataatggc agcaatcctg      420

gcatacacca taggaacgac acatttccag agagtcctga ttttcatcct actgacagct      480

gtcgctcctt caatgacaat gcgttgcata ggaatatcaa atagagactt tgtagaaggg      540

gtttcaggag gaagttgggt tgacatagtc ttagaacatg gaagctgtgt gacgacgatg      600

gcaaaaaaca aaccaacatt ggatttcgaa ctgataaaaa cggaagccaa acagcctgcc      660

accctaagga agtactgcat agaagcaaaa ctaaccaaca caacaacaga atcccgttgc      720

ccaacacaag gggaacccag cctaaaagaa gagcaggaca agaggttcgt ctgcaaacac      780

tccatggtag acagaggatg gggaaatgga tgtggattat ttggaaaggg aggcattgtg      840

acctgtgcta tgttcacatg caaaaagaac atggaaggga aaatcgtgca accagaaaac      900

ttggaataca ccattgtggt aacacctcac tcaggggaag agcatgcggt cggaaatgac      960

acaggaaaac acggcaagga aatcaaagta acaccacaga gttccatcac agaagcagaa     1020

ctgacaggtt atggcaccgt cacgatggag tgctccccga gaacaggcct cgacttcaat     1080

gagatggtgt tgctgcagat ggaaaataaa gcttggctgg tgcataggca atggtttcta     1140

gacctgccat taccatggct gcccggagcg gataaacaag aatcaaattg gatacagaaa     1200

gaaacattgg tcactttcaa aaatccccat gcgaagaaac aggatgttgt tgttttagga     1260

tcccaagaag gggccatgca tacagcactc acaggagcca cagaaatcca aatgtcgtca     1320

ggaaacttgc tcttcactgg acatctcaag tgcaggctga gaatggacaa gctacagctt     1380

aaaggaatgt catactctat gtgcacagga aagtttaaag ttgtgaagga aatagcagaa     1440

acacaacatg gaacgatagt tatcagagtg caatatgaag gggacggctc tccatgtaaa     1500

attccttttg agataatgga tttggaaaaa agatatgtct taggccgcct gatcacagtc     1560

aacccaattg taacagaaaa agacagccca gtcaacatag aagcagaacc tccattcgga     1620

gacagttaca tcatcatagg agtagagccg ggacaactga agctcaactg gttcaagaaa     1680

ggaagttcta tcggccaaat gtttgagaca acgatgagag gggcgaagag aatggccatt     1740

ttgggtgaca cagcctggga cttcggatcc ctgggaggag tgtttacatc tataggaaaa     1800

gctctccacc aagtctttgg agcgatctat ggggctgcct tcagtggggt ttcatggacc     1860

atgaaaatcc tcataggagt cattatcaca tggataggaa tgaactcacg cagcacctca     1920

ctgtctgtgt cactggtact ggtgggaatt gtgacactgt atttaggagt catggtgcag     1980

gcc                                                                   1983


<210>  2
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clinical trial circulating strain

<400>  2

Phe His Leu Thr Thr Arg Asn Gly Glu Pro His Met Ile Val Gly Ile 
1               5                   10                  15      


Gln Glu Lys Gly Lys Ser Leu Leu Phe Lys Thr Glu Asp Gly Val Asn 
            20                  25                  30          


Met Cys Thr Leu Met Ala Met Asp Leu Gly Glu Leu Cys Glu Asp Thr 
        35                  40                  45              


Ile Thr Tyr Lys Cys Pro Leu Leu Arg Gln Asn Glu Pro Glu Asp Ile 
    50                  55                  60                  


Asp Cys Trp Cys Asn Ser Thr Ser Thr Trp Val Thr Tyr Gly Thr Cys 
65                  70                  75                  80  


Thr Thr Thr Gly Glu His Arg Arg Glu Lys Arg Ser Val Ala Leu Val 
                85                  90                  95      


Pro His Val Gly Met Gly Leu Glu Thr Arg Thr Glu Thr Trp Met Ser 
            100                 105                 110         


Ser Glu Gly Ala Trp Lys His Ala Gln Arg Ile Glu Thr Trp Ile Leu 
        115                 120                 125             


Arg His Pro Gly Phe Thr Ile Met Ala Ala Ile Leu Ala Tyr Thr Ile 
    130                 135                 140                 


Gly Thr Thr His Phe Gln Arg Val Leu Ile Phe Ile Leu Leu Thr Ala 
145                 150                 155                 160 


Val Ala Pro Ser Met Thr Met Arg Cys Ile Gly Ile Ser Asn Arg Asp 
                165                 170                 175     


Phe Val Glu Gly Val Ser Gly Gly Ser Trp Val Asp Ile Val Leu Glu 
            180                 185                 190         


His Gly Ser Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr Leu Asp 
        195                 200                 205             


Phe Glu Leu Ile Lys Thr Glu Ala Lys Gln Pro Ala Thr Leu Arg Lys 
    210                 215                 220                 


Tyr Cys Ile Glu Ala Lys Leu Thr Asn Thr Thr Thr Glu Ser Arg Cys 
225                 230                 235                 240 


Pro Thr Gln Gly Glu Pro Ser Leu Lys Glu Glu Gln Asp Lys Arg Phe 
                245                 250                 255     


Val Cys Lys His Ser Met Val Asp Arg Gly Trp Gly Asn Gly Cys Gly 
            260                 265                 270         


Leu Phe Gly Lys Gly Gly Ile Val Thr Cys Ala Met Phe Thr Cys Lys 
        275                 280                 285             


Lys Asn Met Glu Gly Lys Ile Val Gln Pro Glu Asn Leu Glu Tyr Thr 
    290                 295                 300                 


Ile Val Val Thr Pro His Ser Gly Glu Glu His Ala Val Gly Asn Asp 
305                 310                 315                 320 


Thr Gly Lys His Gly Lys Glu Ile Lys Val Thr Pro Gln Ser Ser Ile 
                325                 330                 335     


Thr Glu Ala Glu Leu Thr Gly Tyr Gly Thr Val Thr Met Glu Cys Ser 
            340                 345                 350         


Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu Gln Met Glu 
        355                 360                 365             


Asn Lys Ala Trp Leu Val His Arg Gln Trp Phe Leu Asp Leu Pro Leu 
    370                 375                 380                 


Pro Trp Leu Pro Gly Ala Asp Lys Gln Glu Ser Asn Trp Ile Gln Lys 
385                 390                 395                 400 


Glu Thr Leu Val Thr Phe Lys Asn Pro His Ala Lys Lys Gln Asp Val 
                405                 410                 415     


Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu Thr Gly 
            420                 425                 430         


Ala Thr Glu Ile Gln Met Ser Ser Gly Asn Leu Leu Phe Thr Gly His 
        435                 440                 445             


Leu Lys Cys Arg Leu Arg Met Asp Lys Leu Gln Leu Lys Gly Met Ser 
    450                 455                 460                 


Tyr Ser Met Cys Thr Gly Lys Phe Lys Val Val Lys Glu Ile Ala Glu 
465                 470                 475                 480 


Thr Gln His Gly Thr Ile Val Ile Arg Val Gln Tyr Glu Gly Asp Gly 
                485                 490                 495     


Ser Pro Cys Lys Ile Pro Phe Glu Ile Met Asp Leu Glu Lys Arg Tyr 
            500                 505                 510         


Val Leu Gly Arg Leu Ile Thr Val Asn Pro Ile Val Thr Glu Lys Asp 
        515                 520                 525             


Ser Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile 
    530                 535                 540                 


Ile Ile Gly Val Glu Pro Gly Gln Leu Lys Leu Asn Trp Phe Lys Lys 
545                 550                 555                 560 


Gly Ser Ser Ile Gly Gln Met Phe Glu Thr Thr Met Arg Gly Ala Lys 
                565                 570                 575     


Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Leu Gly 
            580                 585                 590         


Gly Val Phe Thr Ser Ile Gly Lys Ala Leu His Gln Val Phe Gly Ala 
        595                 600                 605             


Ile Tyr Gly Ala Ala Phe Ser Gly Val Ser Trp Thr Met Lys Ile Leu 
    610                 615                 620                 


Ile Gly Val Ile Ile Thr Trp Ile Gly Met Asn Ser Arg Ser Thr Ser 
625                 630                 635                 640 


Leu Ser Val Ser Leu Val Leu Val Gly Ile Val Thr Leu Tyr Leu Gly 
                645                 650                 655     


Val Met Val Gln Ala 
            660     


<210>  3
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  prM+E universal serotype 2


<220>
<221>  Variant
<222>  (295)..(295)
<223>  Xaa can be Val or Ile

<220>
<221>  Variant
<222>  (474)..(474)
<223>  Xaa can be Val or Ile

<400>  3

Phe His Leu Thr Thr Arg Asn Gly Glu Pro His Met Ile Val Gly Arg 
1               5                   10                  15      


Gln Glu Lys Gly Lys Ser Leu Leu Phe Lys Thr Glu Asp Gly Val Asn 
            20                  25                  30          


Met Cys Thr Leu Met Ala Ile Asp Leu Gly Glu Leu Cys Glu Asp Thr 
        35                  40                  45              


Ile Thr Tyr Lys Cys Pro Leu Leu Arg Gln Asn Glu Pro Glu Asp Ile 
    50                  55                  60                  


Asp Cys Trp Cys Asn Ser Thr Ser Thr Trp Val Thr Tyr Gly Thr Cys 
65                  70                  75                  80  


Thr Thr Thr Gly Glu His Arg Arg Glu Lys Arg Ser Val Ala Leu Val 
                85                  90                  95      


Pro His Val Gly Met Gly Leu Glu Thr Arg Thr Glu Thr Trp Met Ser 
            100                 105                 110         


Ser Glu Gly Ala Trp Lys His Val Gln Arg Ile Glu Thr Trp Ile Leu 
        115                 120                 125             


Arg His Pro Gly Phe Thr Ile Met Ala Ala Ile Leu Ala Tyr Thr Ile 
    130                 135                 140                 


Gly Thr Thr His Phe Gln Arg Ala Leu Ile Phe Ile Leu Leu Thr Ala 
145                 150                 155                 160 


Val Ala Pro Ser Met Thr Met Arg Cys Ile Gly Ile Ser Asn Arg Asp 
                165                 170                 175     


Phe Val Glu Gly Val Ser Gly Gly Ser Trp Val Asp Ile Val Leu Glu 
            180                 185                 190         


His Gly Ser Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr Leu Asp 
        195                 200                 205             


Phe Glu Leu Ile Lys Thr Glu Ala Lys Gln Pro Ala Thr Leu Arg Lys 
    210                 215                 220                 


Tyr Cys Ile Glu Ala Lys Leu Thr Asn Thr Thr Thr Glu Ser Arg Cys 
225                 230                 235                 240 


Pro Thr Gln Gly Glu Pro Ser Leu Asn Glu Glu Gln Asp Lys Arg Phe 
                245                 250                 255     


Val Cys Lys His Ser Met Val Asp Arg Gly Trp Gly Asn Gly Cys Gly 
            260                 265                 270         


Leu Phe Gly Lys Gly Gly Ile Val Thr Cys Ala Met Phe Thr Cys Lys 
        275                 280                 285             


Lys Asn Met Glu Gly Lys Xaa Val Gln Pro Glu Asn Leu Glu Tyr Thr 
    290                 295                 300                 


Ile Val Ile Thr Pro His Ser Gly Glu Glu His Ala Val Gly Asn Asp 
305                 310                 315                 320 


Thr Gly Lys His Gly Lys Glu Ile Lys Ile Thr Pro Gln Ser Ser Ile 
                325                 330                 335     


Thr Glu Ala Glu Leu Thr Gly Tyr Gly Thr Val Thr Met Glu Cys Ser 
            340                 345                 350         


Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu Gln Met Glu 
        355                 360                 365             


Asp Lys Ala Trp Leu Val His Arg Gln Trp Phe Leu Asp Leu Pro Leu 
    370                 375                 380                 


Pro Trp Leu Pro Gly Ala Asp Thr Gln Gly Ser Asn Trp Ile Gln Lys 
385                 390                 395                 400 


Glu Thr Leu Val Thr Phe Lys Asn Pro His Ala Lys Lys Gln Asp Val 
                405                 410                 415     


Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu Thr Gly 
            420                 425                 430         


Ala Thr Glu Ile Gln Met Ser Ser Gly Asn Leu Leu Phe Thr Gly His 
        435                 440                 445             


Leu Lys Cys Arg Leu Arg Met Asp Lys Leu Gln Leu Lys Gly Met Ser 
    450                 455                 460                 


Tyr Ser Met Cys Thr Gly Lys Phe Lys Xaa Val Lys Glu Ile Ala Glu 
465                 470                 475                 480 


Thr Gln His Gly Thr Ile Val Ile Arg Val Gln Tyr Glu Gly Asp Gly 
                485                 490                 495     


Ser Pro Cys Lys Ile Pro Phe Glu Ile Met Asp Leu Glu Lys Arg His 
            500                 505                 510         


Val Leu Gly Arg Leu Ile Thr Val Asn Pro Ile Val Thr Glu Lys Asp 
        515                 520                 525             


Ser Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile 
    530                 535                 540                 


Ile Ile Gly Val Glu Pro Gly Gln Leu Lys Leu Asn Trp Phe Lys Lys 
545                 550                 555                 560 


Gly Ser Ser Ile Gly Gln Met Phe Glu Thr Thr Met Arg Gly Ala Lys 
                565                 570                 575     


Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Leu Gly 
            580                 585                 590         


Gly Val Phe Thr Ser Ile Gly Lys Ala Leu His Gln Val Phe Gly Ala 
        595                 600                 605             


Ile Tyr Gly Ala Ala Phe Ser Gly Val Ser Trp Thr Met Lys Ile Leu 
    610                 615                 620                 


Ile Gly Val Ile Ile Thr Trp Ile Gly Met Asn Ser Arg Ser Thr Ser 
625                 630                 635                 640 


Leu Ser Val Ser Leu Val Leu Val Gly Val Val Thr Leu Tyr Leu Gly 
                645                 650                 655     


Val Met Val Gln Ala 
            660     


<210>  4
<211>  1983
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prM+E LAV2

<400>  4
ttccatttaa ccacacgtaa cggagaacca cacatgatcg tcagcagaca agagaaaggg       60

aaaagtcttc tgtttaaaac agaggttggc gtgaacatgt gtaccctcat ggccatggac      120

cttggtgaat tgtgtgaaga cacaatcacg tacaagtgtc cccttctcag gcagaatgag      180

ccagaagaca tagactgttg gtgcaactct acgtccacgt gggtaactta tgggacgtgt      240

accaccatgg gagaacatag aagagaaaaa agatcagtgg cactcgttcc acatgtggga      300

atgggactgg agacacgaac tgaaacatgg atgtcatcag aaggggcctg gaaacatgtc      360

cagagaattg aaacttggat cttgagacat ccaggcttca ccatgatggc agcaatcctg      420

gcatacacca taggaacgac acatttccaa agagccctga ttttcatctt actgacagct      480

gtcactcctt caatgacaat gcgttgcata ggaatgtcaa atagagactt tgtggaaggg      540

gtttcaggag gaagctgggt tgacatagtc ttagaacatg gaagctgtgt gacgacgatg      600

gcaaaaaaca aaccaacatt ggattttgaa ctgataaaaa cagaagccaa acagcctgcc      660

accctaagga agtactgtat agaggcaaag ctaaccaaca caacaacaga atctcgctgc      720

ccaacacaag gggaacccag cctaaatgaa gagcaggaca aaaggttcgt ctgcaaacac      780

tccatggtag acagaggatg gggaaatgga tgtggactat ttggaaaggg aggcattgtg      840

acctgtgcta tgttcagatg caaaaagaac atggaaggaa aagttgtgca accagaaaac      900

ttggaataca ccattgtgat aacacctcac tcaggggaag agcatgcagt cggaaatgac      960

acaggaaaac atggcaagga aatcaaaata acaccacaga gttccatcac agaagcagaa     1020

ttgacaggtt atggcactgt cacaatggag tgctctccaa gaacgggcct cgacttcaat     1080

gagatggtgt tgctgcagat ggaaaataaa gcttggctgg tgcacaggca atggttccta     1140

gacctgccgt taccatggtt gcccggagcg gacacacaag ggtcaaattg gatacagaaa     1200

gagacattgg tcactttcaa aaatccccat gcgaagaaac aggatgttgt tgttttagga     1260

tcccaagaag gggccatgca cacagcactt acaggggcca cagaaatcca aatgtcatca     1320

ggaaacttac tcttcacagg acatctcaag tgcaggctga gaatggacaa gctacagctc     1380

aaaggaatgt catactctat gtgcacagga aagtttaaag ttgtgaagga aatagcagaa     1440

acacaacatg gaacaatagt tatcagagtg caatatgaag gggacggctc tccatgcaag     1500

atcccttttg agataatgga tttggaaaaa agacatgtct taggtcgcct gattacagtc     1560

aacccaattg tgacagaaaa agatagccca gtcaacatag aagcagaacc tccatttgga     1620

gacagctaca tcatcatagg agtagagccg ggacaactga agctcaactg gtttaagaaa     1680

ggaagttcta tcggccaaat gtttgagaca acaatgaggg gggcgaagag aatggccatt     1740

ttaggtgaca cagcctggga ttttggatcc ttgggaggag tgtttacatc tataggaaag     1800

gctctccacc aagtctttgg agcaatctat ggagctgcct tcagtggggt ttcatggact     1860

atgaaaatcc tcataggagt cattatcaca tggataggaa tgaattcacg cagcacctca     1920

ctgtctgtga cactagtatt ggtgggaatt gtgacactgt atttgggagt catggtgcag     1980

gcc                                                                   1983


<210>  5
<211>  1983
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prM+E BID/V585

<400>  5
ttccatttaa ccacacgtaa tggagaacca cacatgatcg ttggtaggca agagaaaggg       60

aaaagtcttc tgtttaaaac agaggatggt gttaacatgt gcaccctcat ggccatagac      120

cttggtgaat tgtgtgaaga tacaatcacg tacaagtgcc ccctcctcag gcaaaatgaa      180

ccagaagaca tagattgttg gtgcaactct acgtccacat gggtaactta tgggacatgt      240

accaccacag gagaacacag aagagaaaaa agatcagtgg cactcgttcc acatgtgggc      300

atgggactgg agacacgaac tgaaacatgg atgtcatcag aaggggcctg gaaacatgtt      360

cagagaattg aaacctggat cttgagacat ccaggcttta ccataatggc agcaatcctg      420

gcatatacca taggaacgac acatttccaa agggctctga tcttcatttt actgacagcc      480

gttgctcctt caatgacaat gcgttgcata ggaatatcaa atagagactt cgtagaaggg      540

gtttcaggag gaagttgggt tgacatagtc ttagaacatg gaagttgtgt gacgacgatg      600

gcaaaaaata aaccaacatt ggattttgaa ctgataaaaa cagaagccaa acaacctgcc      660

actctaagga agtactgtat agaagcaaag ctgaccaata caacaacaga atctcgttgc      720

ccaacacaag gggaacccag tctaaatgaa gagcaggaca aaaggttcat ctgcaaacac      780

tccatggtag acagaggatg gggaaatgga tgtggattat ttggaaaggg aggcattgtg      840

acctgtgcta tgttcacatg caaaaagaac atggaaggaa aagtcgtgca gccagaaaat      900

ctggaataca ccatcgtgat aacacctcac tcaggagaag agcacgctgt aggtaatgac      960

acaggaaagc atggcaagga aatcaaaata acaccacaga gctccatcac agaagcagaa     1020

ctgacaggct atggcactgt cacgatggag tgctctccga gaacgggcct cgacttcaat     1080

gagatggtac tgctgcagat ggaagacaaa gcttggctgg tgcacaggca atggttccta     1140

gacctgccgt taccatggct acccggagcg gacacacaag gatcaaattg gatacagaaa     1200

gagacgttgg tcactttcaa aaatccccac gcgaagaaac aggacgtcgt tgttttagga     1260

tctcaagaag gggccatgca cacggcactt acaggggcca cagaaatcca gatgtcatca     1320

ggaaacttac tgttcacagg acatctcaag tgtaggctga gaatggacaa attacagctt     1380

aaaggaatgt catactctat gtgtacagga aagtttaaaa ttgtgaagga aatagcagaa     1440

acacaacatg gaacaatagt tatcagagta caatatgaag gggacggctc tccatgtaag     1500

attccttttg agataatgga tttggaaaaa agacacgtcc taggtcgcct gattacagtg     1560

aacccaatcg taacagaaaa agatagccca gtcaacatag aagcagaacc tccattcgga     1620

gacagctaca tcatcatagg agtagagccg ggacaattga aactcaattg gttcaagaag     1680

ggaagttcca ttggccaaat gtttgagaca acaatgagag gagcgaagag aatggccatt     1740

ttaggtgaca cagcctggga ttttggatcc ctgggaggag tgtttacatc tataggaaag     1800

gctctccacc aagttttcgg agcaatctat ggggctgctt ttagtggggt ctcatggact     1860

atgaaaatcc tcataggagt tattatcaca tggataggaa tgaattcacg tagcacctca     1920

ctgtctgtgt cactagtatt ggtgggagtc gtgacactgt acttgggggt tatggtgcag     1980

gct                                                                   1983


<210>  6
<211>  1983
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prM+E PR/DB023

<400>  6
ttccatttaa ccacacgtaa tggagaacca cacatgatcg ttggtaggca agagaaaggg       60

aaaagtcttc tgttcaaaac agaggatggt gttaacatgt gtaccctcat ggccatagac      120

cttggtgaat tgtgtgaaga tacaatcacg tacaagtgcc ccctcctcag gcaaaatgaa      180

ccagaagaca tagattgttg gtgcaactct acgtccacat gggtaactta tgggacatgt      240

accaccacag gagaacacag aagagaaaaa agatcagtgg cactcgttcc acatgtgggc      300

atgggactgg agacacgaac tgaaacatgg atgtcatcag aaggggcctg gaaacatgtt      360

cagagaattg aaacctggat attgagacat ccaggcttta ccataatggc agcaatcctg      420

gcatatacca taggaacgac acatttccaa agggctctga tcttcatttt actgacagcc      480

gtcgctcctt caatgacaat gcgttgcata ggaatatcaa atagagactt cgtagaaggg      540

gtttcaggag gaagttgggt tgacatagtc ttagaacatg gaagttgtgt gacgacgatg      600

gcaaaaaata aaccaacatt ggattttgaa ctgataaaaa cagaagccaa acaacctgcc      660

actctaagga agtactgtat agaagcaaag ctgaccaata caacaacaga atctcgttgc      720

ccaacacaag gggaacccag tctaaatgaa gagcaggaca aaaggttcat ctgcaaacac      780

tccatggtag acagaggatg gggaaatgga tgtggattat ttggaaaagg aggcattgta      840

acctgtgcta tgttcacatg caaaaagaac atggaaggaa aagttgtgct gccagaaaat      900

ctggaataca ccatcgtgat aacacctcac tcaggagaag agcacgctgt aggtaatgac      960

acaggaaaac atggcaagga aattaaaata acaccacaga gttccatcac agaagcagaa     1020

ctgacaggct atggcactgt cacgatggag tgctctccga gaacgggcct cgacttcaat     1080

gagatggtgc tgctgcagat ggaagacaaa gcctggctgg tgcacaggca atggttccta     1140

gatctgccgt taccatggct acccggagcg gacacacaag gatcaaattg gatacagaaa     1200

gagacgttgg tcactttcaa aaatccccac gcgaagaaac aggacgtcgt tgttttagga     1260

tctcaagaag gggccatgca cacggcactt acaggggcca cagaaatcca gatgtcatca     1320

ggaaacttac tgttcacagg acatctcaag tgtaggctga gaatggacaa attacagctt     1380

aaaggaatgt catactctat gtgtacagga aagtttaaaa ttgtgaagga aatagcagaa     1440

acacaacatg gaacaatagt tatcagagta caatatgaag gggacggctc tccatgtaag     1500

attccttttg agataatgga tttagaaaaa agacacgtcc taggtcgcct gattacagtg     1560

aacccaatcg taacagaaaa agatagccca gtcaacatag aagcagaacc tccattcgga     1620

gacagctaca tcatcatagg agtagagccg ggacaattga aactcaattg gttcaagaag     1680

ggaagttcca ttggccaaat gtttgagaca acaatgagag gagcgaagag aatggccatt     1740

ttaggtgaca cagcctggga ttttggatcc ctgggaggag tgtttacatc tataggaaag     1800

gctctccacc aagttttcgg agcaatctat ggggctgctt ttagtggggt ctcatggact     1860

atgaaaatcc tcataggagt tatcatcaca tggataggaa tgaattcacg tagcacctca     1920

ctgtctgtgt cactagtatt ggtgggagtc gtgacactgt acttgggggt tatggtgcag     1980

gct                                                                   1983


<210>  7
<211>  1983
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prM+E MD1280

<400>  7
ttccatttaa ccacacgaaa tggagaacca cacatgatcg ttggcagaca agagaaaggg       60

aaaagccttc tgtttaaaac agaggatggt gtgaacatgt gtaccctcat ggccattgat      120

cttggtgaat tgtgtgaaga tacaatcacg tacaagtgcc ccctcctcag gcagaatgaa      180

ccagaagata tagattgttg gtgcaactcc acgtccacat gggtaactta tgggacgtgt      240

accaccacag gagaacacag aagagaaaaa agatcagtgg cactcgttcc acatgtgggt      300

atgggactgg agacacgaac tgaaacatgg atgtcgtcag aaggggcctg gaaacacgct      360

cagagaattg aaacttggat cttgagacat ccaggcttta ccataatggc agcaatcctg      420

gcatataccg taggaacgac acatttccaa agggccctga ttttcatctt actggcagct      480

gtcgctcctt caatgacaat gcgttgcata ggaatatcaa atagagactt tgtagaaggg      540

gtttcaggag gaagctgggt tgacatagtc ttagaacatg gaagttgtgt gacgacaatg      600

gcaaaaaata aaccaacact ggattttgaa ctgataaaaa cagaagccaa acaacctgcc      660

actctaagga agtactgtat agaggcaaag ctgaccaata caacaacaga atctcgttgc      720

ccaacacaag gggaacccag tctaaatgaa gagcaggaca aaaggttcgt ctgcaaacac      780

tccatggtag acagaggatg gggaaatgga tgtggattat ttggaaaggg aggcattgtg      840

acctgtgcta tgttcacatg caaaaagaac atggaaggaa aaatcgtgca accagaaaat      900

ttggaataca ccatcgtgat aacacctcac tcaggagaag agcacgctgt aggtaatgac      960

acaggaaaac atggtaagga aattaaaata acaccacaga gttccatcac agaagcagaa     1020

ctgacaggct atggcacagt cacgatggag tgctctccga gaacgggcct tgacttcaat     1080

gagatggtgc tgctgcagat ggaagataaa gcttggctgg tgcacaggca atggttccta     1140

gacctgccgt taccatggct acccggagcg gacacacaag gatcaaattg gatacagaaa     1200

gagacattgg tcactttcaa aaatccccac gcgaagaagc aggatgtcgt tgttttagga     1260

tctcaagaag gagccatgca cacggcactc acaggggcca cagaaatcca gatgtcatca     1320

ggaaacttac tattcacagg acatctcaaa tgcaggctga gaatggacaa actacagctc     1380

aaaggaatgt catactctat gtgtacagga aagtttaaaa ttgtgaagga aatagcagaa     1440

acacaacatg gaacaatagt tatcagagta caatatgaag gagacggctc tccatgtaag     1500

atcccttttg aaataatgga tttggaaaaa agacatgtct taggtcgcct gattacagtt     1560

aatccgatcg taacagaaaa agatagccca gtcaacatag aagcagaacc tccattcgga     1620

gacagctaca tcattatagg agtagagccg ggacaattga aactcaactg gttcaagaaa     1680

ggaagttcca tcggccaaat gtttgagacg acaatgagag gagcaaagag aatggccatt     1740

ttaggtgaca cagcctggga ttttggatct ctgggaggag tgtttacatc tataggaaag     1800

gctctccacc aagttttcgg agcaatctat ggggctgcct ttagtggggt ttcatggact     1860

atgaaaatcc tcataggagt catcatcaca tggataggaa tgaattcacg tagcacctca     1920

ctgtctgtgt cactagtatt ggtgggaatc ataacactgt acttgggagc tatggtgcag     1980

gct                                                                   1983


<210>  8
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  prM+E LAV2

<400>  8

Phe His Leu Thr Thr Arg Asn Gly Glu Pro His Met Ile Val Ser Arg 
1               5                   10                  15      


Gln Glu Lys Gly Lys Ser Leu Leu Phe Lys Thr Glu Val Gly Val Asn 
            20                  25                  30          


Met Cys Thr Leu Met Ala Met Asp Leu Gly Glu Leu Cys Glu Asp Thr 
        35                  40                  45              


Ile Thr Tyr Lys Cys Pro Leu Leu Arg Gln Asn Glu Pro Glu Asp Ile 
    50                  55                  60                  


Asp Cys Trp Cys Asn Ser Thr Ser Thr Trp Val Thr Tyr Gly Thr Cys 
65                  70                  75                  80  


Thr Thr Met Gly Glu His Arg Arg Glu Lys Arg Ser Val Ala Leu Val 
                85                  90                  95      


Pro His Val Gly Met Gly Leu Glu Thr Arg Thr Glu Thr Trp Met Ser 
            100                 105                 110         


Ser Glu Gly Ala Trp Lys His Val Gln Arg Ile Glu Thr Trp Ile Leu 
        115                 120                 125             


Arg His Pro Gly Phe Thr Met Met Ala Ala Ile Leu Ala Tyr Thr Ile 
    130                 135                 140                 


Gly Thr Thr His Phe Gln Arg Ala Leu Ile Phe Ile Leu Leu Thr Ala 
145                 150                 155                 160 


Val Thr Pro Ser Met Thr Met Arg Cys Ile Gly Met Ser Asn Arg Asp 
                165                 170                 175     


Phe Val Glu Gly Val Ser Gly Gly Ser Trp Val Asp Ile Val Leu Glu 
            180                 185                 190         


His Gly Ser Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr Leu Asp 
        195                 200                 205             


Phe Glu Leu Ile Lys Thr Glu Ala Lys Gln Pro Ala Thr Leu Arg Lys 
    210                 215                 220                 


Tyr Cys Ile Glu Ala Lys Leu Thr Asn Thr Thr Thr Glu Ser Arg Cys 
225                 230                 235                 240 


Pro Thr Gln Gly Glu Pro Ser Leu Asn Glu Glu Gln Asp Lys Arg Phe 
                245                 250                 255     


Val Cys Lys His Ser Met Val Asp Arg Gly Trp Gly Asn Gly Cys Gly 
            260                 265                 270         


Leu Phe Gly Lys Gly Gly Ile Val Thr Cys Ala Met Phe Arg Cys Lys 
        275                 280                 285             


Lys Asn Met Glu Gly Lys Val Val Gln Pro Glu Asn Leu Glu Tyr Thr 
    290                 295                 300                 


Ile Val Ile Thr Pro His Ser Gly Glu Glu His Ala Val Gly Asn Asp 
305                 310                 315                 320 


Thr Gly Lys His Gly Lys Glu Ile Lys Ile Thr Pro Gln Ser Ser Ile 
                325                 330                 335     


Thr Glu Ala Glu Leu Thr Gly Tyr Gly Thr Val Thr Met Glu Cys Ser 
            340                 345                 350         


Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu Gln Met Glu 
        355                 360                 365             


Asn Lys Ala Trp Leu Val His Arg Gln Trp Phe Leu Asp Leu Pro Leu 
    370                 375                 380                 


Pro Trp Leu Pro Gly Ala Asp Thr Gln Gly Ser Asn Trp Ile Gln Lys 
385                 390                 395                 400 


Glu Thr Leu Val Thr Phe Lys Asn Pro His Ala Lys Lys Gln Asp Val 
                405                 410                 415     


Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu Thr Gly 
            420                 425                 430         


Ala Thr Glu Ile Gln Met Ser Ser Gly Asn Leu Leu Phe Thr Gly His 
        435                 440                 445             


Leu Lys Cys Arg Leu Arg Met Asp Lys Leu Gln Leu Lys Gly Met Ser 
    450                 455                 460                 


Tyr Ser Met Cys Thr Gly Lys Phe Lys Val Val Lys Glu Ile Ala Glu 
465                 470                 475                 480 


Thr Gln His Gly Thr Ile Val Ile Arg Val Gln Tyr Glu Gly Asp Gly 
                485                 490                 495     


Ser Pro Cys Lys Ile Pro Phe Glu Ile Met Asp Leu Glu Lys Arg His 
            500                 505                 510         


Val Leu Gly Arg Leu Ile Thr Val Asn Pro Ile Val Thr Glu Lys Asp 
        515                 520                 525             


Ser Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile 
    530                 535                 540                 


Ile Ile Gly Val Glu Pro Gly Gln Leu Lys Leu Asn Trp Phe Lys Lys 
545                 550                 555                 560 


Gly Ser Ser Ile Gly Gln Met Phe Glu Thr Thr Met Arg Gly Ala Lys 
                565                 570                 575     


Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Leu Gly 
            580                 585                 590         


Gly Val Phe Thr Ser Ile Gly Lys Ala Leu His Gln Val Phe Gly Ala 
        595                 600                 605             


Ile Tyr Gly Ala Ala Phe Ser Gly Val Ser Trp Thr Met Lys Ile Leu 
    610                 615                 620                 


Ile Gly Val Ile Ile Thr Trp Ile Gly Met Asn Ser Arg Ser Thr Ser 
625                 630                 635                 640 


Leu Ser Val Thr Leu Val Leu Val Gly Ile Val Thr Leu Tyr Leu Gly 
                645                 650                 655     


Val Met Val Gln Ala 
            660     


<210>  9
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  prM+E BID/V585

<400>  9

Phe His Leu Thr Thr Arg Asn Gly Glu Pro His Met Ile Val Gly Arg 
1               5                   10                  15      


Gln Glu Lys Gly Lys Ser Leu Leu Phe Lys Thr Glu Asp Gly Val Asn 
            20                  25                  30          


Met Cys Thr Leu Met Ala Ile Asp Leu Gly Glu Leu Cys Glu Asp Thr 
        35                  40                  45              


Ile Thr Tyr Lys Cys Pro Leu Leu Arg Gln Asn Glu Pro Glu Asp Ile 
    50                  55                  60                  


Asp Cys Trp Cys Asn Ser Thr Ser Thr Trp Val Thr Tyr Gly Thr Cys 
65                  70                  75                  80  


Thr Thr Thr Gly Glu His Arg Arg Glu Lys Arg Ser Val Ala Leu Val 
                85                  90                  95      


Pro His Val Gly Met Gly Leu Glu Thr Arg Thr Glu Thr Trp Met Ser 
            100                 105                 110         


Ser Glu Gly Ala Trp Lys His Val Gln Arg Ile Glu Thr Trp Ile Leu 
        115                 120                 125             


Arg His Pro Gly Phe Thr Ile Met Ala Ala Ile Leu Ala Tyr Thr Ile 
    130                 135                 140                 


Gly Thr Thr His Phe Gln Arg Ala Leu Ile Phe Ile Leu Leu Thr Ala 
145                 150                 155                 160 


Val Ala Pro Ser Met Thr Met Arg Cys Ile Gly Ile Ser Asn Arg Asp 
                165                 170                 175     


Phe Val Glu Gly Val Ser Gly Gly Ser Trp Val Asp Ile Val Leu Glu 
            180                 185                 190         


His Gly Ser Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr Leu Asp 
        195                 200                 205             


Phe Glu Leu Ile Lys Thr Glu Ala Lys Gln Pro Ala Thr Leu Arg Lys 
    210                 215                 220                 


Tyr Cys Ile Glu Ala Lys Leu Thr Asn Thr Thr Thr Glu Ser Arg Cys 
225                 230                 235                 240 


Pro Thr Gln Gly Glu Pro Ser Leu Asn Glu Glu Gln Asp Lys Arg Phe 
                245                 250                 255     


Ile Cys Lys His Ser Met Val Asp Arg Gly Trp Gly Asn Gly Cys Gly 
            260                 265                 270         


Leu Phe Gly Lys Gly Gly Ile Val Thr Cys Ala Met Phe Thr Cys Lys 
        275                 280                 285             


Lys Asn Met Glu Gly Lys Val Val Gln Pro Glu Asn Leu Glu Tyr Thr 
    290                 295                 300                 


Ile Val Ile Thr Pro His Ser Gly Glu Glu His Ala Val Gly Asn Asp 
305                 310                 315                 320 


Thr Gly Lys His Gly Lys Glu Ile Lys Ile Thr Pro Gln Ser Ser Ile 
                325                 330                 335     


Thr Glu Ala Glu Leu Thr Gly Tyr Gly Thr Val Thr Met Glu Cys Ser 
            340                 345                 350         


Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu Gln Met Glu 
        355                 360                 365             


Asp Lys Ala Trp Leu Val His Arg Gln Trp Phe Leu Asp Leu Pro Leu 
    370                 375                 380                 


Pro Trp Leu Pro Gly Ala Asp Thr Gln Gly Ser Asn Trp Ile Gln Lys 
385                 390                 395                 400 


Glu Thr Leu Val Thr Phe Lys Asn Pro His Ala Lys Lys Gln Asp Val 
                405                 410                 415     


Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu Thr Gly 
            420                 425                 430         


Ala Thr Glu Ile Gln Met Ser Ser Gly Asn Leu Leu Phe Thr Gly His 
        435                 440                 445             


Leu Lys Cys Arg Leu Arg Met Asp Lys Leu Gln Leu Lys Gly Met Ser 
    450                 455                 460                 


Tyr Ser Met Cys Thr Gly Lys Phe Lys Ile Val Lys Glu Ile Ala Glu 
465                 470                 475                 480 


Thr Gln His Gly Thr Ile Val Ile Arg Val Gln Tyr Glu Gly Asp Gly 
                485                 490                 495     


Ser Pro Cys Lys Ile Pro Phe Glu Ile Met Asp Leu Glu Lys Arg His 
            500                 505                 510         


Val Leu Gly Arg Leu Ile Thr Val Asn Pro Ile Val Thr Glu Lys Asp 
        515                 520                 525             


Ser Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile 
    530                 535                 540                 


Ile Ile Gly Val Glu Pro Gly Gln Leu Lys Leu Asn Trp Phe Lys Lys 
545                 550                 555                 560 


Gly Ser Ser Ile Gly Gln Met Phe Glu Thr Thr Met Arg Gly Ala Lys 
                565                 570                 575     


Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Leu Gly 
            580                 585                 590         


Gly Val Phe Thr Ser Ile Gly Lys Ala Leu His Gln Val Phe Gly Ala 
        595                 600                 605             


Ile Tyr Gly Ala Ala Phe Ser Gly Val Ser Trp Thr Met Lys Ile Leu 
    610                 615                 620                 


Ile Gly Val Ile Ile Thr Trp Ile Gly Met Asn Ser Arg Ser Thr Ser 
625                 630                 635                 640 


Leu Ser Val Ser Leu Val Leu Val Gly Val Val Thr Leu Tyr Leu Gly 
                645                 650                 655     


Val Met Val Gln Ala 
            660     


<210>  10
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  prM+E PR/DB023

<400>  10

Phe His Leu Thr Thr Arg Asn Gly Glu Pro His Met Ile Val Gly Arg 
1               5                   10                  15      


Gln Glu Lys Gly Lys Ser Leu Leu Phe Lys Thr Glu Asp Gly Val Asn 
            20                  25                  30          


Met Cys Thr Leu Met Ala Ile Asp Leu Gly Glu Leu Cys Glu Asp Thr 
        35                  40                  45              


Ile Thr Tyr Lys Cys Pro Leu Leu Arg Gln Asn Glu Pro Glu Asp Ile 
    50                  55                  60                  


Asp Cys Trp Cys Asn Ser Thr Ser Thr Trp Val Thr Tyr Gly Thr Cys 
65                  70                  75                  80  


Thr Thr Thr Gly Glu His Arg Arg Glu Lys Arg Ser Val Ala Leu Val 
                85                  90                  95      


Pro His Val Gly Met Gly Leu Glu Thr Arg Thr Glu Thr Trp Met Ser 
            100                 105                 110         


Ser Glu Gly Ala Trp Lys His Val Gln Arg Ile Glu Thr Trp Ile Leu 
        115                 120                 125             


Arg His Pro Gly Phe Thr Ile Met Ala Ala Ile Leu Ala Tyr Thr Ile 
    130                 135                 140                 


Gly Thr Thr His Phe Gln Arg Ala Leu Ile Phe Ile Leu Leu Thr Ala 
145                 150                 155                 160 


Val Ala Pro Ser Met Thr Met Arg Cys Ile Gly Ile Ser Asn Arg Asp 
                165                 170                 175     


Phe Val Glu Gly Val Ser Gly Gly Ser Trp Val Asp Ile Val Leu Glu 
            180                 185                 190         


His Gly Ser Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr Leu Asp 
        195                 200                 205             


Phe Glu Leu Ile Lys Thr Glu Ala Lys Gln Pro Ala Thr Leu Arg Lys 
    210                 215                 220                 


Tyr Cys Ile Glu Ala Lys Leu Thr Asn Thr Thr Thr Glu Ser Arg Cys 
225                 230                 235                 240 


Pro Thr Gln Gly Glu Pro Ser Leu Asn Glu Glu Gln Asp Lys Arg Phe 
                245                 250                 255     


Ile Cys Lys His Ser Met Val Asp Arg Gly Trp Gly Asn Gly Cys Gly 
            260                 265                 270         


Leu Phe Gly Lys Gly Gly Ile Val Thr Cys Ala Met Phe Thr Cys Lys 
        275                 280                 285             


Lys Asn Met Glu Gly Lys Val Val Leu Pro Glu Asn Leu Glu Tyr Thr 
    290                 295                 300                 


Ile Val Ile Thr Pro His Ser Gly Glu Glu His Ala Val Gly Asn Asp 
305                 310                 315                 320 


Thr Gly Lys His Gly Lys Glu Ile Lys Ile Thr Pro Gln Ser Ser Ile 
                325                 330                 335     


Thr Glu Ala Glu Leu Thr Gly Tyr Gly Thr Val Thr Met Glu Cys Ser 
            340                 345                 350         


Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu Gln Met Glu 
        355                 360                 365             


Asp Lys Ala Trp Leu Val His Arg Gln Trp Phe Leu Asp Leu Pro Leu 
    370                 375                 380                 


Pro Trp Leu Pro Gly Ala Asp Thr Gln Gly Ser Asn Trp Ile Gln Lys 
385                 390                 395                 400 


Glu Thr Leu Val Thr Phe Lys Asn Pro His Ala Lys Lys Gln Asp Val 
                405                 410                 415     


Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu Thr Gly 
            420                 425                 430         


Ala Thr Glu Ile Gln Met Ser Ser Gly Asn Leu Leu Phe Thr Gly His 
        435                 440                 445             


Leu Lys Cys Arg Leu Arg Met Asp Lys Leu Gln Leu Lys Gly Met Ser 
    450                 455                 460                 


Tyr Ser Met Cys Thr Gly Lys Phe Lys Ile Val Lys Glu Ile Ala Glu 
465                 470                 475                 480 


Thr Gln His Gly Thr Ile Val Ile Arg Val Gln Tyr Glu Gly Asp Gly 
                485                 490                 495     


Ser Pro Cys Lys Ile Pro Phe Glu Ile Met Asp Leu Glu Lys Arg His 
            500                 505                 510         


Val Leu Gly Arg Leu Ile Thr Val Asn Pro Ile Val Thr Glu Lys Asp 
        515                 520                 525             


Ser Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile 
    530                 535                 540                 


Ile Ile Gly Val Glu Pro Gly Gln Leu Lys Leu Asn Trp Phe Lys Lys 
545                 550                 555                 560 


Gly Ser Ser Ile Gly Gln Met Phe Glu Thr Thr Met Arg Gly Ala Lys 
                565                 570                 575     


Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Leu Gly 
            580                 585                 590         


Gly Val Phe Thr Ser Ile Gly Lys Ala Leu His Gln Val Phe Gly Ala 
        595                 600                 605             


Ile Tyr Gly Ala Ala Phe Ser Gly Val Ser Trp Thr Met Lys Ile Leu 
    610                 615                 620                 


Ile Gly Val Ile Ile Thr Trp Ile Gly Met Asn Ser Arg Ser Thr Ser 
625                 630                 635                 640 


Leu Ser Val Ser Leu Val Leu Val Gly Val Val Thr Leu Tyr Leu Gly 
                645                 650                 655     


Val Met Val Gln Ala 
            660     


<210>  11
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  prM+E MD1280

<400>  11

Phe His Leu Thr Thr Arg Asn Gly Glu Pro His Met Ile Val Gly Arg 
1               5                   10                  15      


Gln Glu Lys Gly Lys Ser Leu Leu Phe Lys Thr Glu Asp Gly Val Asn 
            20                  25                  30          


Met Cys Thr Leu Met Ala Ile Asp Leu Gly Glu Leu Cys Glu Asp Thr 
        35                  40                  45              


Ile Thr Tyr Lys Cys Pro Leu Leu Arg Gln Asn Glu Pro Glu Asp Ile 
    50                  55                  60                  


Asp Cys Trp Cys Asn Ser Thr Ser Thr Trp Val Thr Tyr Gly Thr Cys 
65                  70                  75                  80  


Thr Thr Thr Gly Glu His Arg Arg Glu Lys Arg Ser Val Ala Leu Val 
                85                  90                  95      


Pro His Val Gly Met Gly Leu Glu Thr Arg Thr Glu Thr Trp Met Ser 
            100                 105                 110         


Ser Glu Gly Ala Trp Lys His Ala Gln Arg Ile Glu Thr Trp Ile Leu 
        115                 120                 125             


Arg His Pro Gly Phe Thr Ile Met Ala Ala Ile Leu Ala Tyr Thr Val 
    130                 135                 140                 


Gly Thr Thr His Phe Gln Arg Ala Leu Ile Phe Ile Leu Leu Ala Ala 
145                 150                 155                 160 


Val Ala Pro Ser Met Thr Met Arg Cys Ile Gly Ile Ser Asn Arg Asp 
                165                 170                 175     


Phe Val Glu Gly Val Ser Gly Gly Ser Trp Val Asp Ile Val Leu Glu 
            180                 185                 190         


His Gly Ser Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr Leu Asp 
        195                 200                 205             


Phe Glu Leu Ile Lys Thr Glu Ala Lys Gln Pro Ala Thr Leu Arg Lys 
    210                 215                 220                 


Tyr Cys Ile Glu Ala Lys Leu Thr Asn Thr Thr Thr Glu Ser Arg Cys 
225                 230                 235                 240 


Pro Thr Gln Gly Glu Pro Ser Leu Asn Glu Glu Gln Asp Lys Arg Phe 
                245                 250                 255     


Val Cys Lys His Ser Met Val Asp Arg Gly Trp Gly Asn Gly Cys Gly 
            260                 265                 270         


Leu Phe Gly Lys Gly Gly Ile Val Thr Cys Ala Met Phe Thr Cys Lys 
        275                 280                 285             


Lys Asn Met Glu Gly Lys Ile Val Gln Pro Glu Asn Leu Glu Tyr Thr 
    290                 295                 300                 


Ile Val Ile Thr Pro His Ser Gly Glu Glu His Ala Val Gly Asn Asp 
305                 310                 315                 320 


Thr Gly Lys His Gly Lys Glu Ile Lys Ile Thr Pro Gln Ser Ser Ile 
                325                 330                 335     


Thr Glu Ala Glu Leu Thr Gly Tyr Gly Thr Val Thr Met Glu Cys Ser 
            340                 345                 350         


Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu Gln Met Glu 
        355                 360                 365             


Asp Lys Ala Trp Leu Val His Arg Gln Trp Phe Leu Asp Leu Pro Leu 
    370                 375                 380                 


Pro Trp Leu Pro Gly Ala Asp Thr Gln Gly Ser Asn Trp Ile Gln Lys 
385                 390                 395                 400 


Glu Thr Leu Val Thr Phe Lys Asn Pro His Ala Lys Lys Gln Asp Val 
                405                 410                 415     


Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu Thr Gly 
            420                 425                 430         


Ala Thr Glu Ile Gln Met Ser Ser Gly Asn Leu Leu Phe Thr Gly His 
        435                 440                 445             


Leu Lys Cys Arg Leu Arg Met Asp Lys Leu Gln Leu Lys Gly Met Ser 
    450                 455                 460                 


Tyr Ser Met Cys Thr Gly Lys Phe Lys Ile Val Lys Glu Ile Ala Glu 
465                 470                 475                 480 


Thr Gln His Gly Thr Ile Val Ile Arg Val Gln Tyr Glu Gly Asp Gly 
                485                 490                 495     


Ser Pro Cys Lys Ile Pro Phe Glu Ile Met Asp Leu Glu Lys Arg His 
            500                 505                 510         


Val Leu Gly Arg Leu Ile Thr Val Asn Pro Ile Val Thr Glu Lys Asp 
        515                 520                 525             


Ser Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile 
    530                 535                 540                 


Ile Ile Gly Val Glu Pro Gly Gln Leu Lys Leu Asn Trp Phe Lys Lys 
545                 550                 555                 560 


Gly Ser Ser Ile Gly Gln Met Phe Glu Thr Thr Met Arg Gly Ala Lys 
                565                 570                 575     


Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Leu Gly 
            580                 585                 590         


Gly Val Phe Thr Ser Ile Gly Lys Ala Leu His Gln Val Phe Gly Ala 
        595                 600                 605             


Ile Tyr Gly Ala Ala Phe Ser Gly Val Ser Trp Thr Met Lys Ile Leu 
    610                 615                 620                 


Ile Gly Val Ile Ile Thr Trp Ile Gly Met Asn Ser Arg Ser Thr Ser 
625                 630                 635                 640 


Leu Ser Val Ser Leu Val Leu Val Gly Ile Ile Thr Leu Tyr Leu Gly 
                645                 650                 655     


Ala Met Val Gln Ala 
            660     


<210>  12
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E universal


<220>
<221>  Variant
<222>  (129)..(129)
<223>  Xaa can be Val or Ile

<220>
<221>  Variant
<222>  (308)..(308)
<223>  Xaa can be Val or Ile

<400>  12

Met Arg Cys Ile Gly Ile Ser Asn Arg Asp Phe Val Glu Gly Val Ser 
1               5                   10                  15      


Gly Gly Ser Trp Val Asp Ile Val Leu Glu His Gly Ser Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr 
        35                  40                  45              


Glu Ala Lys Gln Pro Ala Thr Leu Arg Lys Tyr Cys Ile Glu Ala Lys 
    50                  55                  60                  


Leu Thr Asn Thr Thr Thr Glu Ser Arg Cys Pro Thr Gln Gly Glu Pro 
65                  70                  75                  80  


Ser Leu Asn Glu Glu Gln Asp Lys Arg Phe Val Cys Lys His Ser Met 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly 
            100                 105                 110         


Ile Val Thr Cys Ala Met Phe Thr Cys Lys Lys Asn Met Glu Gly Lys 
        115                 120                 125             


Xaa Val Gln Pro Glu Asn Leu Glu Tyr Thr Ile Val Ile Thr Pro His 
    130                 135                 140                 


Ser Gly Glu Glu His Ala Val Gly Asn Asp Thr Gly Lys His Gly Lys 
145                 150                 155                 160 


Glu Ile Lys Ile Thr Pro Gln Ser Ser Ile Thr Glu Ala Glu Leu Thr 
                165                 170                 175     


Gly Tyr Gly Thr Val Thr Met Glu Cys Ser Pro Arg Thr Gly Leu Asp 
            180                 185                 190         


Phe Asn Glu Met Val Leu Leu Gln Met Glu Asp Lys Ala Trp Leu Val 
        195                 200                 205             


His Arg Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Leu Pro Gly Ala 
    210                 215                 220                 


Asp Thr Gln Gly Ser Asn Trp Ile Gln Lys Glu Thr Leu Val Thr Phe 
225                 230                 235                 240 


Lys Asn Pro His Ala Lys Lys Gln Asp Val Val Val Leu Gly Ser Gln 
                245                 250                 255     


Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Met 
            260                 265                 270         


Ser Ser Gly Asn Leu Leu Phe Thr Gly His Leu Lys Cys Arg Leu Arg 
        275                 280                 285             


Met Asp Lys Leu Gln Leu Lys Gly Met Ser Tyr Ser Met Cys Thr Gly 
    290                 295                 300                 


Lys Phe Lys Xaa Val Lys Glu Ile Ala Glu Thr Gln His Gly Thr Ile 
305                 310                 315                 320 


Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys Lys Ile Pro 
                325                 330                 335     


Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly Arg Leu Ile 
            340                 345                 350         


Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val Asn Ile Glu 
        355                 360                 365             


Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly Val Glu Pro 
    370                 375                 380                 


Gly Gln Leu Lys Leu Asn Trp Phe Lys Lys Gly Ser Ser Ile Gly Gln 
385                 390                 395                 400 


Met Phe Glu Thr Thr Met Arg Gly Ala Lys Arg Met Ala Ile Leu Gly 
                405                 410                 415     


Asp Thr Ala Trp Asp Phe Gly Ser Leu Gly Gly Val Phe Thr Ser Ile 
            420                 425                 430         


Gly Lys Ala Leu His Gln Val Phe Gly Ala Ile Tyr Gly Ala Ala Phe 
        435                 440                 445             


Ser Gly Val Ser Trp Thr Met Lys Ile Leu Ile Gly Val Ile Ile Thr 
    450                 455                 460                 


Trp Ile Gly Met Asn Ser Arg Ser Thr Ser Leu Ser Val Ser Leu Val 
465                 470                 475                 480 


Leu Val Gly Val Val Thr Leu Tyr Leu Gly Val Met Val Gln Ala 
                485                 490                 495 


<210>  13
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E LAV2

<400>  13

Met Arg Cys Ile Gly Met Ser Asn Arg Asp Phe Val Glu Gly Val Ser 
1               5                   10                  15      


Gly Gly Ser Trp Val Asp Ile Val Leu Glu His Gly Ser Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr 
        35                  40                  45              


Glu Ala Lys Gln Pro Ala Thr Leu Arg Lys Tyr Cys Ile Glu Ala Lys 
    50                  55                  60                  


Leu Thr Asn Thr Thr Thr Glu Ser Arg Cys Pro Thr Gln Gly Glu Pro 
65                  70                  75                  80  


Ser Leu Asn Glu Glu Gln Asp Lys Arg Phe Val Cys Lys His Ser Met 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly 
            100                 105                 110         


Ile Val Thr Cys Ala Met Phe Arg Cys Lys Lys Asn Met Glu Gly Lys 
        115                 120                 125             


Val Val Gln Pro Glu Asn Leu Glu Tyr Thr Ile Val Ile Thr Pro His 
    130                 135                 140                 


Ser Gly Glu Glu His Ala Val Gly Asn Asp Thr Gly Lys His Gly Lys 
145                 150                 155                 160 


Glu Ile Lys Ile Thr Pro Gln Ser Ser Ile Thr Glu Ala Glu Leu Thr 
                165                 170                 175     


Gly Tyr Gly Thr Val Thr Met Glu Cys Ser Pro Arg Thr Gly Leu Asp 
            180                 185                 190         


Phe Asn Glu Met Val Leu Leu Gln Met Glu Asn Lys Ala Trp Leu Val 
        195                 200                 205             


His Arg Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Leu Pro Gly Ala 
    210                 215                 220                 


Asp Thr Gln Gly Ser Asn Trp Ile Gln Lys Glu Thr Leu Val Thr Phe 
225                 230                 235                 240 


Lys Asn Pro His Ala Lys Lys Gln Asp Val Val Val Leu Gly Ser Gln 
                245                 250                 255     


Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Met 
            260                 265                 270         


Ser Ser Gly Asn Leu Leu Phe Thr Gly His Leu Lys Cys Arg Leu Arg 
        275                 280                 285             


Met Asp Lys Leu Gln Leu Lys Gly Met Ser Tyr Ser Met Cys Thr Gly 
    290                 295                 300                 


Lys Phe Lys Val Val Lys Glu Ile Ala Glu Thr Gln His Gly Thr Ile 
305                 310                 315                 320 


Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys Lys Ile Pro 
                325                 330                 335     


Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly Arg Leu Ile 
            340                 345                 350         


Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val Asn Ile Glu 
        355                 360                 365             


Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly Val Glu Pro 
    370                 375                 380                 


Gly Gln Leu Lys Leu Asn Trp Phe Lys Lys Gly Ser Ser Ile Gly Gln 
385                 390                 395                 400 


Met Phe Glu Thr Thr Met Arg Gly Ala Lys Arg Met Ala Ile Leu Gly 
                405                 410                 415     


Asp Thr Ala Trp Asp Phe Gly Ser Leu Gly Gly Val Phe Thr Ser Ile 
            420                 425                 430         


Gly Lys Ala Leu His Gln Val Phe Gly Ala Ile Tyr Gly Ala Ala Phe 
        435                 440                 445             


Ser Gly Val Ser Trp Thr Met Lys Ile Leu Ile Gly Val Ile Ile Thr 
    450                 455                 460                 


Trp Ile Gly Met Asn Ser Arg Ser Thr Ser Leu Ser Val Thr Leu Val 
465                 470                 475                 480 


Leu Val Gly Ile Val Thr Leu Tyr Leu Gly Val Met Val Gln Ala 
                485                 490                 495 


<210>  14
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E BID/V585

<400>  14

Met Arg Cys Ile Gly Ile Ser Asn Arg Asp Phe Val Glu Gly Val Ser 
1               5                   10                  15      


Gly Gly Ser Trp Val Asp Ile Val Leu Glu His Gly Ser Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr 
        35                  40                  45              


Glu Ala Lys Gln Pro Ala Thr Leu Arg Lys Tyr Cys Ile Glu Ala Lys 
    50                  55                  60                  


Leu Thr Asn Thr Thr Thr Glu Ser Arg Cys Pro Thr Gln Gly Glu Pro 
65                  70                  75                  80  


Ser Leu Asn Glu Glu Gln Asp Lys Arg Phe Ile Cys Lys His Ser Met 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly 
            100                 105                 110         


Ile Val Thr Cys Ala Met Phe Thr Cys Lys Lys Asn Met Glu Gly Lys 
        115                 120                 125             


Val Val Gln Pro Glu Asn Leu Glu Tyr Thr Ile Val Ile Thr Pro His 
    130                 135                 140                 


Ser Gly Glu Glu His Ala Val Gly Asn Asp Thr Gly Lys His Gly Lys 
145                 150                 155                 160 


Glu Ile Lys Ile Thr Pro Gln Ser Ser Ile Thr Glu Ala Glu Leu Thr 
                165                 170                 175     


Gly Tyr Gly Thr Val Thr Met Glu Cys Ser Pro Arg Thr Gly Leu Asp 
            180                 185                 190         


Phe Asn Glu Met Val Leu Leu Gln Met Glu Asp Lys Ala Trp Leu Val 
        195                 200                 205             


His Arg Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Leu Pro Gly Ala 
    210                 215                 220                 


Asp Thr Gln Gly Ser Asn Trp Ile Gln Lys Glu Thr Leu Val Thr Phe 
225                 230                 235                 240 


Lys Asn Pro His Ala Lys Lys Gln Asp Val Val Val Leu Gly Ser Gln 
                245                 250                 255     


Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Met 
            260                 265                 270         


Ser Ser Gly Asn Leu Leu Phe Thr Gly His Leu Lys Cys Arg Leu Arg 
        275                 280                 285             


Met Asp Lys Leu Gln Leu Lys Gly Met Ser Tyr Ser Met Cys Thr Gly 
    290                 295                 300                 


Lys Phe Lys Ile Val Lys Glu Ile Ala Glu Thr Gln His Gly Thr Ile 
305                 310                 315                 320 


Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys Lys Ile Pro 
                325                 330                 335     


Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly Arg Leu Ile 
            340                 345                 350         


Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val Asn Ile Glu 
        355                 360                 365             


Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly Val Glu Pro 
    370                 375                 380                 


Gly Gln Leu Lys Leu Asn Trp Phe Lys Lys Gly Ser Ser Ile Gly Gln 
385                 390                 395                 400 


Met Phe Glu Thr Thr Met Arg Gly Ala Lys Arg Met Ala Ile Leu Gly 
                405                 410                 415     


Asp Thr Ala Trp Asp Phe Gly Ser Leu Gly Gly Val Phe Thr Ser Ile 
            420                 425                 430         


Gly Lys Ala Leu His Gln Val Phe Gly Ala Ile Tyr Gly Ala Ala Phe 
        435                 440                 445             


Ser Gly Val Ser Trp Thr Met Lys Ile Leu Ile Gly Val Ile Ile Thr 
    450                 455                 460                 


Trp Ile Gly Met Asn Ser Arg Ser Thr Ser Leu Ser Val Ser Leu Val 
465                 470                 475                 480 


Leu Val Gly Val Val Thr Leu Tyr Leu Gly Val Met Val Gln Ala 
                485                 490                 495 


<210>  15
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E PR/DB023

<400>  15

Met Arg Cys Ile Gly Ile Ser Asn Arg Asp Phe Val Glu Gly Val Ser 
1               5                   10                  15      


Gly Gly Ser Trp Val Asp Ile Val Leu Glu His Gly Ser Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr 
        35                  40                  45              


Glu Ala Lys Gln Pro Ala Thr Leu Arg Lys Tyr Cys Ile Glu Ala Lys 
    50                  55                  60                  


Leu Thr Asn Thr Thr Thr Glu Ser Arg Cys Pro Thr Gln Gly Glu Pro 
65                  70                  75                  80  


Ser Leu Asn Glu Glu Gln Asp Lys Arg Phe Ile Cys Lys His Ser Met 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly 
            100                 105                 110         


Ile Val Thr Cys Ala Met Phe Thr Cys Lys Lys Asn Met Glu Gly Lys 
        115                 120                 125             


Val Val Leu Pro Glu Asn Leu Glu Tyr Thr Ile Val Ile Thr Pro His 
    130                 135                 140                 


Ser Gly Glu Glu His Ala Val Gly Asn Asp Thr Gly Lys His Gly Lys 
145                 150                 155                 160 


Glu Ile Lys Ile Thr Pro Gln Ser Ser Ile Thr Glu Ala Glu Leu Thr 
                165                 170                 175     


Gly Tyr Gly Thr Val Thr Met Glu Cys Ser Pro Arg Thr Gly Leu Asp 
            180                 185                 190         


Phe Asn Glu Met Val Leu Leu Gln Met Glu Asp Lys Ala Trp Leu Val 
        195                 200                 205             


His Arg Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Leu Pro Gly Ala 
    210                 215                 220                 


Asp Thr Gln Gly Ser Asn Trp Ile Gln Lys Glu Thr Leu Val Thr Phe 
225                 230                 235                 240 


Lys Asn Pro His Ala Lys Lys Gln Asp Val Val Val Leu Gly Ser Gln 
                245                 250                 255     


Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Met 
            260                 265                 270         


Ser Ser Gly Asn Leu Leu Phe Thr Gly His Leu Lys Cys Arg Leu Arg 
        275                 280                 285             


Met Asp Lys Leu Gln Leu Lys Gly Met Ser Tyr Ser Met Cys Thr Gly 
    290                 295                 300                 


Lys Phe Lys Ile Val Lys Glu Ile Ala Glu Thr Gln His Gly Thr Ile 
305                 310                 315                 320 


Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys Lys Ile Pro 
                325                 330                 335     


Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly Arg Leu Ile 
            340                 345                 350         


Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val Asn Ile Glu 
        355                 360                 365             


Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly Val Glu Pro 
    370                 375                 380                 


Gly Gln Leu Lys Leu Asn Trp Phe Lys Lys Gly Ser Ser Ile Gly Gln 
385                 390                 395                 400 


Met Phe Glu Thr Thr Met Arg Gly Ala Lys Arg Met Ala Ile Leu Gly 
                405                 410                 415     


Asp Thr Ala Trp Asp Phe Gly Ser Leu Gly Gly Val Phe Thr Ser Ile 
            420                 425                 430         


Gly Lys Ala Leu His Gln Val Phe Gly Ala Ile Tyr Gly Ala Ala Phe 
        435                 440                 445             


Ser Gly Val Ser Trp Thr Met Lys Ile Leu Ile Gly Val Ile Ile Thr 
    450                 455                 460                 


Trp Ile Gly Met Asn Ser Arg Ser Thr Ser Leu Ser Val Ser Leu Val 
465                 470                 475                 480 


Leu Val Gly Val Val Thr Leu Tyr Leu Gly Val Met Val Gln Ala 
                485                 490                 495 


<210>  16
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E MD1280

<400>  16

Met Arg Cys Ile Gly Ile Ser Asn Arg Asp Phe Val Glu Gly Val Ser 
1               5                   10                  15      


Gly Gly Ser Trp Val Asp Ile Val Leu Glu His Gly Ser Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr 
        35                  40                  45              


Glu Ala Lys Gln Pro Ala Thr Leu Arg Lys Tyr Cys Ile Glu Ala Lys 
    50                  55                  60                  


Leu Thr Asn Thr Thr Thr Glu Ser Arg Cys Pro Thr Gln Gly Glu Pro 
65                  70                  75                  80  


Ser Leu Asn Glu Glu Gln Asp Lys Arg Phe Val Cys Lys His Ser Met 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly 
            100                 105                 110         


Ile Val Thr Cys Ala Met Phe Thr Cys Lys Lys Asn Met Glu Gly Lys 
        115                 120                 125             


Ile Val Gln Pro Glu Asn Leu Glu Tyr Thr Ile Val Ile Thr Pro His 
    130                 135                 140                 


Ser Gly Glu Glu His Ala Val Gly Asn Asp Thr Gly Lys His Gly Lys 
145                 150                 155                 160 


Glu Ile Lys Ile Thr Pro Gln Ser Ser Ile Thr Glu Ala Glu Leu Thr 
                165                 170                 175     


Gly Tyr Gly Thr Val Thr Met Glu Cys Ser Pro Arg Thr Gly Leu Asp 
            180                 185                 190         


Phe Asn Glu Met Val Leu Leu Gln Met Glu Asp Lys Ala Trp Leu Val 
        195                 200                 205             


His Arg Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Leu Pro Gly Ala 
    210                 215                 220                 


Asp Thr Gln Gly Ser Asn Trp Ile Gln Lys Glu Thr Leu Val Thr Phe 
225                 230                 235                 240 


Lys Asn Pro His Ala Lys Lys Gln Asp Val Val Val Leu Gly Ser Gln 
                245                 250                 255     


Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Met 
            260                 265                 270         


Ser Ser Gly Asn Leu Leu Phe Thr Gly His Leu Lys Cys Arg Leu Arg 
        275                 280                 285             


Met Asp Lys Leu Gln Leu Lys Gly Met Ser Tyr Ser Met Cys Thr Gly 
    290                 295                 300                 


Lys Phe Lys Ile Val Lys Glu Ile Ala Glu Thr Gln His Gly Thr Ile 
305                 310                 315                 320 


Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys Lys Ile Pro 
                325                 330                 335     


Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly Arg Leu Ile 
            340                 345                 350         


Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val Asn Ile Glu 
        355                 360                 365             


Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly Val Glu Pro 
    370                 375                 380                 


Gly Gln Leu Lys Leu Asn Trp Phe Lys Lys Gly Ser Ser Ile Gly Gln 
385                 390                 395                 400 


Met Phe Glu Thr Thr Met Arg Gly Ala Lys Arg Met Ala Ile Leu Gly 
                405                 410                 415     


Asp Thr Ala Trp Asp Phe Gly Ser Leu Gly Gly Val Phe Thr Ser Ile 
            420                 425                 430         


Gly Lys Ala Leu His Gln Val Phe Gly Ala Ile Tyr Gly Ala Ala Phe 
        435                 440                 445             


Ser Gly Val Ser Trp Thr Met Lys Ile Leu Ile Gly Val Ile Ile Thr 
    450                 455                 460                 


Trp Ile Gly Met Asn Ser Arg Ser Thr Ser Leu Ser Val Ser Leu Val 
465                 470                 475                 480 


Leu Val Gly Ile Ile Thr Leu Tyr Leu Gly Ala Met Val Gln Ala 
                485                 490                 495 


<210>  17
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M consensus


<400>  17

Ser Val Ala Leu Val Pro His Val Gly Met Gly Leu Glu Thr Arg Thr 
1               5                   10                  15      


Glu Thr Trp Met Ser Ser Glu Gly Ala Trp Lys His Val Gln Arg Ile 
            20                  25                  30          


Glu Thr Trp Ile Leu Arg His Pro Gly Phe Thr Ile Met Ala Ala Ile 
        35                  40                  45              


Leu Ala Tyr Thr Ile Gly Thr Thr His Phe Gln Arg Ala Leu Ile Phe 
    50                  55                  60                  


Ile Leu Leu Thr Ala Val Ala Pro Ser Met Thr 
65                  70                  75 


<210>  18
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E circulating strain

<400>  18

Met Arg Cys Ile Gly Ile Ser Asn Arg Asp Phe Val Glu Gly Val Ser 
1               5                   10                  15      


Gly Gly Ser Trp Val Asp Ile Val Leu Glu His Gly Ser Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr 
        35                  40                  45              


Glu Ala Lys Gln Pro Ala Thr Leu Arg Lys Tyr Cys Ile Glu Ala Lys 
    50                  55                  60                  


Leu Thr Asn Thr Thr Thr Glu Ser Arg Cys Pro Thr Gln Gly Glu Pro 
65                  70                  75                  80  


Ser Leu Lys Glu Glu Gln Asp Lys Arg Phe Val Cys Lys His Ser Met 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly 
            100                 105                 110         


Ile Val Thr Cys Ala Met Phe Thr Cys Lys Lys Asn Met Glu Gly Lys 
        115                 120                 125             


Ile Val Gln Pro Glu Asn Leu Glu Tyr Thr Ile Val Val Thr Pro His 
    130                 135                 140                 


Ser Gly Glu Glu His Ala Val Gly Asn Asp Thr Gly Lys His Gly Lys 
145                 150                 155                 160 


Glu Ile Lys Val Thr Pro Gln Ser Ser Ile Thr Glu Ala Glu Leu Thr 
                165                 170                 175     


Gly Tyr Gly Thr Val Thr Met Glu Cys Ser Pro Arg Thr Gly Leu Asp 
            180                 185                 190         


Phe Asn Glu Met Val Leu Leu Gln Met Glu Asn Lys Ala Trp Leu Val 
        195                 200                 205             


His Arg Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Leu Pro Gly Ala 
    210                 215                 220                 


Asp Lys Gln Glu Ser Asn Trp Ile Gln Lys Glu Thr Leu Val Thr Phe 
225                 230                 235                 240 


Lys Asn Pro His Ala Lys Lys Gln Asp Val Val Val Leu Gly Ser Gln 
                245                 250                 255     


Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Met 
            260                 265                 270         


Ser Ser Gly Asn Leu Leu Phe Thr Gly His Leu Lys Cys Arg Leu Arg 
        275                 280                 285             


Met Asp Lys Leu Gln Leu Lys Gly Met Ser Tyr Ser Met Cys Thr Gly 
    290                 295                 300                 


Lys Phe Lys Val Val Lys Glu Ile Ala Glu Thr Gln His Gly Thr Ile 
305                 310                 315                 320 


Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys Lys Ile Pro 
                325                 330                 335     


Phe Glu Ile Met Asp Leu Glu Lys Arg Tyr Val Leu Gly Arg Leu Ile 
            340                 345                 350         


Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val Asn Ile Glu 
        355                 360                 365             


Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly Val Glu Pro 
    370                 375                 380                 


Gly Gln Leu Lys Leu Asn Trp Phe Lys Lys Gly Ser Ser Ile Gly Gln 
385                 390                 395                 400 


Met Phe Glu Thr Thr Met Arg Gly Ala Lys Arg Met Ala Ile Leu Gly 
                405                 410                 415     


Asp Thr Ala Trp Asp Phe Gly Ser Leu Gly Gly Val Phe Thr Ser Ile 
            420                 425                 430         


Gly Lys Ala Leu His Gln Val Phe Gly Ala Ile Tyr Gly Ala Ala Phe 
        435                 440                 445             


Ser Gly Val Ser Trp Thr Met Lys Ile Leu Ile Gly Val Ile Ile Thr 
    450                 455                 460                 


Trp Ile Gly Met Asn Ser Arg Ser Thr Ser Leu Ser Val Ser Leu Val 
465                 470                 475                 480 


Leu Val Gly Ile Val Thr Leu Tyr Leu Gly Val Met Val Gln Ala 
                485                 490                 495 


<210>  19
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M LAV2

<400>  19

Ser Val Ala Leu Val Pro His Val Gly Met Gly Leu Glu Thr Arg Thr 
1               5                   10                  15      


Glu Thr Trp Met Ser Ser Glu Gly Ala Trp Lys His Val Gln Arg Ile 
            20                  25                  30          


Glu Thr Trp Ile Leu Arg His Pro Gly Phe Thr Met Met Ala Ala Ile 
        35                  40                  45              


Leu Ala Tyr Thr Ile Gly Thr Thr His Phe Gln Arg Ala Leu Ile Phe 
    50                  55                  60                  


Ile Leu Leu Thr Ala Val Thr Pro Ser Met Thr 
65                  70                  75  


<210>  20
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M BID/V585

<400>  20

Ser Val Ala Leu Val Pro His Val Gly Met Gly Leu Glu Thr Arg Thr 
1               5                   10                  15      


Glu Thr Trp Met Ser Ser Glu Gly Ala Trp Lys His Val Gln Arg Ile 
            20                  25                  30          


Glu Thr Trp Ile Leu Arg His Pro Gly Phe Thr Ile Met Ala Ala Ile 
        35                  40                  45              


Leu Ala Tyr Thr Ile Gly Thr Thr His Phe Gln Arg Ala Leu Ile Phe 
    50                  55                  60                  


Ile Leu Leu Thr Ala Val Ala Pro Ser Met Thr 
65                  70                  75  


<210>  21
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M PR/DB023

<400>  21

Ser Val Ala Leu Val Pro His Val Gly Met Gly Leu Glu Thr Arg Thr 
1               5                   10                  15      


Glu Thr Trp Met Ser Ser Glu Gly Ala Trp Lys His Val Gln Arg Ile 
            20                  25                  30          


Glu Thr Trp Ile Leu Arg His Pro Gly Phe Thr Ile Met Ala Ala Ile 
        35                  40                  45              


Leu Ala Tyr Thr Ile Gly Thr Thr His Phe Gln Arg Ala Leu Ile Phe 
    50                  55                  60                  


Ile Leu Leu Thr Ala Val Ala Pro Ser Met Thr 
65                  70                  75  


<210>  22
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M MD1280

<400>  22

Ser Val Ala Leu Val Pro His Val Gly Met Gly Leu Glu Thr Arg Thr 
1               5                   10                  15      


Glu Thr Trp Met Ser Ser Glu Gly Ala Trp Lys His Ala Gln Arg Ile 
            20                  25                  30          


Glu Thr Trp Ile Leu Arg His Pro Gly Phe Thr Ile Met Ala Ala Ile 
        35                  40                  45              


Leu Ala Tyr Thr Val Gly Thr Thr His Phe Gln Arg Ala Leu Ile Phe 
    50                  55                  60                  


Ile Leu Leu Ala Ala Val Ala Pro Ser Met Thr 
65                  70                  75  


<210>  23
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M clinical trial circulating strain

<400>  23

Ser Val Ala Leu Val Pro His Val Gly Met Gly Leu Glu Thr Arg Thr 
1               5                   10                  15      


Glu Thr Trp Met Ser Ser Glu Gly Ala Trp Lys His Ala Gln Arg Ile 
            20                  25                  30          


Glu Thr Trp Ile Leu Arg His Pro Gly Phe Thr Ile Met Ala Ala Ile 
        35                  40                  45              


Leu Ala Tyr Thr Ile Gly Thr Thr His Phe Gln Arg Val Leu Ile Phe 
    50                  55                  60                  


Ile Leu Leu Thr Ala Val Ala Pro Ser Met Thr 
65                  70                  75  


<210>  24
<211>  10723
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  VDV2

<400>  24
aguuguuagu cuacguggac cgacaaagac agauucuuug agggagcuaa gcucaaugua       60

guucuaacag uuuuuuaauu agagagcaga ucucugauga auaaccaacg gaaaaaggcg      120

aaaaacacgc cuuucaauau gcugaaacgc gagagaaacc gcgugucgac ugugcaacag      180

cugacaaaga gauucucacu uggaaugcug cagggacgag gaccauuaaa acuguucaug      240

gcccuggugg cguuccuucg uuuccuaaca aucccaccaa cagcagggau auugaagaga      300

uggggaacaa uuaaaaaauc aaaagcuauu aauguuuuga gaggguucag gaaagagauu      360

ggaaggaugc ugaacaucuu gaauaggaga cgcagaucug caggcaugau cauuaugcug      420

auuccaacag ugauggcguu ccauuuaacc acacguaacg gagaaccaca caugaucguc      480

agcagacaag agaaagggaa aagucuucug uuuaaaacag agguuggcgu gaacaugugu      540

acccucaugg ccauggaccu uggugaauug ugugaagaca caaucacgua caaguguccc      600

cuucucaggc agaaugagcc agaagacaua gacuguuggu gcaacucuac guccacgugg      660

guaacuuaug ggacguguac caccauggga gaacauagaa gagaaaaaag aucaguggca      720

cucguuccac augugcgaau gggacuggag acacgaacug aaacauggau gucaucagaa      780

ggggccugga aacaugucca gagaauugaa acuuggaucu ugagacaucc aggcuucacc      840

augauggcag caauccuggc auacaccaua ggaacgacac auuuccaaag agcccugauu      900

uucaucuuac ugacagcugu cacuccuuca augacaaugc guugcauagg aaugucaaau      960

agagacuuug uggaaggggu uucaggagga agcuggguug acauagucuu agaacaugga     1020

agcuguguga cgacgauggc aaaaaacaaa ccaacauugg auuuugaacu gauaaaaaca     1080

gaagccaaac agccugccac ccuaaggaag uacuguauag aggcaaagcu aaccaacaca     1140

acaacagaau cucgcugccc aacacaaggg gaacccagcc uaaaugaaga gcaggacaaa     1200

agguucgucu gcaaacacuc caugguagac agaggauggg gaaauggaug uggacuauuu     1260

ggaaagggag gcauugugac cugugcuaug uucagaugca aaaagaacau ggaaggaaaa     1320

guugugcaac cagaaaacuu ggaauacacc auugugauaa caccucacuc aggggaagag     1380

caugcagucg gaaaugacac aggaaaacau ggcaaggaaa ucaaaauaac accacagagu     1440

uccaucacag aagcagaauu gacagguuau ggcacuguca caauggagug cucuccaaga     1500

acgggccucg acuucaauga gaugguguug cugcagaugg aaaauaaagc uuggcuggug     1560

cacaggcaau gguuccuaga ccugccguua ccaugguugc ccggagcgga cacacaagag     1620

ucaaauugga uacagaagga gacauugguc acuuucaaaa auccccaugc gaagaaacag     1680

gauguuguug uuuuaggauc ccaagaaggg gccaugcaca cagcacuuac aggggccaca     1740

gaaauccaaa ugucaucagg aaacuuacuc uucacaggac aucucaagug caggcugaga     1800

auggacaagc uacagcucaa aggaauguca uacucuaugu gcacaggaaa guuuaaaguu     1860

gugaaggaaa uagcagaaac acaacaugga acaauaguua ucagagugca auaugaaggg     1920

gacggcucuc caugcaagau cccuuuugag auaauggauu uggaaaaaag acaugucuua     1980

ggucgccuga uuacagucaa cccaauugug acagaaaaag auagcccagu caacauagaa     2040

gcagaaccuc cauuuggaga cagcuacauc aucauaggag uagagccggg acaacugaag     2100

cucaacuggu uuaagaaagg aaguucuauc ggccaaaugu uugagacaac aaugaggggg     2160

gcgaagagaa uggccauuuu aggugacaca gccugggauu uuggauccuu gggaggagug     2220

uuuacaucua uaggaaaggc ucuccaccaa gucuuuggag caaucuaugg agcugccuuc     2280

agugggguuu cauggacuau gaaaauccuc auaggaguca uuaucacaug gauaggaaug     2340

aauucacgca gcaccucacu gucugugaca cuaguauugg ugggaauugu gacacuguau     2400

uugggaguca uggugcaggc cgauaguggu ugcguuguga gcuggaaaaa caaagaacug     2460

aaauguggca gugggauuuu caucacagac aacgugcaca cauggacaga acaauacaaa     2520

uuccaaccag aauccccuuc aaaacuagcu ucagcuaucc agaaagccca ugaagaggac     2580

auuuguggaa uccgcucagu aacaagacug gagaaucuga uguggaaaca aauaacacca     2640

gaauugaauc acauucuauc agaaaaugag gugaaguuaa cuauuaugac aggagacauc     2700

aaaggaauca ugcaggcagg aaaacgaucu cugcggccuc agcccacuga gcugaaguau     2760

ucauggaaaa cauggggcaa agcaaaaaug cucucuacag agucucauaa ccagaccuuu     2820

cucauugaug gccccgaaac agcagaaugc cccaacacaa auagagcuug gaauucguug     2880

gaaguugaag acuauggcuu uggaguauuc accaccaaua uauggcuaaa auugaaagaa     2940

aaacaggaug uauucugcga cucaaaacuc augucagcgg ccauaaaaga caacagagcc     3000

guccaugccg auauggguua uuggauagaa agugcacuca augacacaug gaagauagag     3060

aaagccucuu ucauugaagu uaaaaacugc cacuggccaa aaucacacac ccucuggagc     3120

aauggagugc uagaaaguga gaugauaauu ccaaagaauc ucgcuggacc agugucucaa     3180

cacaacuaua gaccaggcua ccauacacaa auaacaggac cauggcaucu agguaagcuu     3240

gagauggacu uugauuucug ugauggaaca acagugguag ugacugagga cugcggaaau     3300

agaggacccu cuuugagaac aaccacugcc ucuggaaaac ucauaacaga auggugcugc     3360

cgaucuugca cauuaccacc gcuaagauac agaggugagg augggugcug guacgggaug     3420

gaaaucagac cauugaagga gaaagaagag aauuugguca acuccuuggu cacagcugga     3480

caugggcagg ucgacaacuu uucacuagga gucuugggaa uggcauuguu ccuggaggaa     3540

augcuuagga cccgaguagg aacgaaacau gcaauacuac uaguugcagu uucuuuugug     3600

acauugauca cagggaacau guccuuuaga gaccugggaa gagugauggu uaugguaggc     3660

gccacuauga cggaugacau agguaugggc gugacuuauc uugcccuacu agcagccuuc     3720

aaagucagac caacuuuugc agcuggacua cucuugagaa agcugaccuc caaggaauug     3780

augaugacua cuauaggaau uguacuccuc ucccagagca ccauaccaga gaccauucuu     3840

gaguugacug augcguuagc cuuaggcaug augguccuca aaauggugag aaauauggaa     3900

aaguaucaau uggcagugac uaucauggcu aucuugugcg ucccaaacgc agugauauua     3960

caaaacgcau ggaaagugag uugcacaaua uuggcagugg uguccguuuc cccacuguuc     4020

uuaacauccu cacagcaaaa aacagauugg auaccauuag cauugacgau caaaggucuc     4080

aauccaacag cuauuuuucu aacaacccuc ucaagaacca gcaagaaaag gagcuggcca     4140

uuaaaugagg cuaucauggc agucgggaug gugagcauuu uagccaguuc ucuccuaaaa     4200

aaugauauuc ccaugacagg accauuagug gcuggagggc uccucacugu gugcuacgug     4260

cucacuggac gaucggccga uuuggaacug gagagagcag ccgaugucaa augggaagac     4320

caggcagaga uaucaggaag caguccaauc cugucaauaa caauaucaga agaugguagc     4380

augucgauaa aaaaugaaga ggaagaacaa acacugacca uacucauuag aacaggauug     4440

cuggugaucu caggacuuuu uccuguauca auaccaauca cggcagcagc augguaccug     4500

ugggaaguga agaaacaacg ggccggagua uugugggaug uuccuucacc cccacccaug     4560

ggaaaggcug aacuggaaga uggagccuau agaauuaagc aaaaagggau ucuuggauau     4620

ucccagaucg gagccggagu uuacaaagaa ggaacauucc auacaaugug gcaugucaca     4680

cguggcgcug uucuaaugca uaaaggaaag aggauugaac caacaugggc ggacgucaag     4740

aaagaccuaa uaucauaugg aggaggcugg aaguuagaag gagaauggaa ggaaggagaa     4800

gaaguccagg uauuggcacu ggagccugga aaaaauccaa gagccgucca aacgaaaccu     4860

ggucuuuuca aaaccaacgc cggaacaaua ggugcuguau cucuggacuu uucuccugga     4920

acgucaggau cuccaauuau cgacaaaaaa ggaaaaguug ugggucuuua ugguaauggu     4980

guuguuacaa ggaguggagc auaugugagu gcuauagccc agacugaaaa aagcauugaa     5040

gacaacccag agaucgaaga ucacauuuuc cgaaagagaa gacugaccau cauggaccuc     5100

cacccaggag cgggaaagac gaagagauac cuuccggcca uagucagaga agcuauaaaa     5160

cgggguuuga gaacauuaau cuuggccccc acuagaguug uggcagcuga aauggaggaa     5220

gcccuuagag gacuuccaau aagauaccag accccagcca ucagagcuga gcacaccggg     5280

cgggagauug uggaccuaau gugucaugcc acauuuacca ugaggcugcu aucaccaguu     5340

agagugccaa acuacaaccu gauuaucaug gacgaagccc auuucacaga cccagcaagu     5400

auagcagcua gaggauacau cucaacucga guggagaugg gugaggcagc ugggauuuuu     5460

augacagcca cucccccggg aagcagagac ccauuuccuc agagcaaugc accaaucaua     5520

gaugaagaaa gagaaauccc ugaacgcucg uggaauuccg gacaugaaug ggucacggau     5580

uuuaaaggga agacuguuug guucguucca aguauaaaag caggaaauga uauagcagcu     5640

ugccugagga aaaauggaaa gaaagugaua caacucagua ggaagaccuu ugauucugag     5700

uaugucaaga cuagaaccaa ugauugggac uucgugguua caacugacau uucagaaaug     5760

ggugccaauu ucaaggcuga gaggguuaua gaccccagac gcugcaugaa accagucaua     5820

cuaacagaug gugaagagcg ggugauucug gcaggaccua ugccagugac ccacucuagu     5880

gcagcacaaa gaagagggag aauaggaaga aauccaaaaa augagaauga ccaguacaua     5940

uacauggggg aaccucugga aaaugaugaa gacugugcac acuggaaaga agcuaaaaug     6000

cuccuagaua acaucaacac gccagaagga aucauuccua gcauguucga accagagcgu     6060

gaaaaggugg augccauuga uggcgaauac cgcuugagag gagaagcaag gaaaaccuuu     6120

guagacuuaa ugagaagagg agaccuacca gucugguugg ccuacagagu ggcagcugaa     6180

ggcaucaacu acgcagacag aagguggugu uuugauggag ucaagaacaa ccaaauccua     6240

gaagaaaacg uggaaguuga aaucuggaca aaagaagggg aaaggaagaa auugaaaccc     6300

agaugguugg augcuaggau cuauucugac ccacuggcgc uaaaagaauu uaaggaauuu     6360

gcagccggaa gaaagucucu gacccugaac cuaaucacag aaauggguag gcucccaacc     6420

uucaugacuc agaaggcaag agacgcacug gacaacuuag cagugcugca cacggcugag     6480

gcagguggaa gggcguacaa ccaugcucuc agugaacugc cggagacccu ggagacauug     6540

cuuuuacuga cacuucuggc uacagucacg ggagggaucu uuuuauucuu gaugagcgca     6600

aggggcauag ggaagaugac ccugggaaug ugcugcauaa ucacggcuag cauccuccua     6660

ugguacgcac aaauacagcc acacuggaua gcagcuucaa uaauacugga guuuuuucuc     6720

auaguuuugc uuauuccaga accugaaaaa cagagaacac cccaagacaa ccaacugacc     6780

uacguuguca uagccauccu cacaguggug gccgcaacca uggcaaacga gauggguuuc     6840

cuagaaaaaa cgaagaaaga ucucggauug ggaagcauug caacccagca acccgagagc     6900

aacauccugg acauagaucu acguccugca ucagcaugga cgcuguaugc cguggccaca     6960

acauuuguua caccaauguu gagacauagc auugaaaauu ccucagugaa ugugucccua     7020

acagcuauag ccaaccaagc cacaguguua augggucucg ggaaaggaug gccauuguca     7080

aagauggaca ucggaguucc ccuucucgcc auuggaugcu acucacaagu caaccccaua     7140

acucucacag cagcucuuuu cuuauuggua gcacauuaug ccaucauagg gccaggacuc     7200

caagcaaaag caaccagaga agcucagaaa agagcagcgg cgggcaucau gaaaaaccca     7260

acugucgaug gaauaacagu gauugaccua gauccaauac cuuaugaucc aaaguuugaa     7320

aagcaguugg gacaaguaau gcuccuaguc cucugcguga cucaaguauu gaugaugagg     7380

acuacauggg cucuguguga ggcuuuaacc uuagcuaccg ggcccaucuc cacauugugg     7440

gaaggaaauc cagggagguu uuggaacacu accauugcgg ugucaauggc uaacauuuuu     7500

agagggaguu acuuggccgg agcuggacuu cucuuuucua uuaugaagaa cacaaccaac     7560

acaagaaggg gaacuggcaa cauaggagag acgcuuggag agaaauggaa aagccgauug     7620

aacgcauugg gaaaaaguga auuccagauc uacaagaaaa guggaaucca ggaaguggau     7680

agaaccuuag caaaagaagg cauuaaaaga ggagaaacgg accaucacgc ugugucgcga     7740

ggcucagcaa aacugagaug guucguugag agaaacaugg ucacaccaga agggaaagua     7800

guggaccucg guuguggcag aggaggcugg ucauacuauu guggaggacu aaagaaugua     7860

agagaaguca aaggccuaac aaaaggagga ccaggacacg aagaacccau ccccauguca     7920

acauaugggu ggaaucuagu gcgucuucaa aguggaguug acguuuucuu caucccgcca     7980

gaaaagugug acacauuauu gugugacaua ggggagucau caccaaaucc cacaguggaa     8040

gcaggacgaa cacucagagu ccuuaacuua guagaaaauu gguugaacaa caacacucaa     8100

uuuugcauaa agguucucaa cccauauaug cccucaguca uagaaaaaau ggaagcacua     8160

caaaggaaau auggaggagc cuuagugagg aauccacucu cacgaaacuc cacacaugag     8220

auguacuggg uauccaaugc uuccgggaac auagugucau cagugaacau gauuucaagg     8280

auguugauca acagauuuac aaugagauac aagaaagcca cuuacgagcc ggauguugac     8340

cucggaagcg gaacccguaa caucgggauu gaaagugaga uaccaaaccu agauauaauu     8400

gggaaaagaa uagaaaaaau aaagcaagag caugaaacau cauggcacua ugaccaagac     8460

cacccauaca aaacgugggc auaccauggu agcuaugaaa caaaacagac uggaucagca     8520

ucauccaugg ucaacggagu ggucaggcug cugacaaaac cuugggacgu uguccccaug     8580

gugacacaga uggcaaugac agacacgacu ccauuuggac aacagcgcgu uuuuaaagag     8640

aaaguggaca cgagaaccca agaaccgaaa gaaggcacga agaaacuaau gaaaauaaca     8700

gcagaguggc uuuggaaaga auuagggaag aaaaagacac ccaggaugug caccagagaa     8760

gaauucacaa gaaaggugag aagcaaugca gccuuggggg ccauauucac ugaugagaac     8820

aaguggaagu cggcacguga ggcuguugaa gauaguaggu uuugggagcu gguugacaag     8880

gaaaggaauc uccaucuuga aggaaagugu gaaacaugug uguacaacau gaugggaaaa     8940

agagagaaga agcuagggga auucggcaag gcaaaaggca gcagagccau augguacaug     9000

uggcuuggag cacgcuucuu agaguuugaa gcccuaggau ucuuaaauga agaucacugg     9060

uucuccagag agaacucccu gaguggagug gaaggagaag ggcugcacaa gcuagguuac     9120

auucuaagag acgugagcaa gaaagaggga ggagcaaugu augccgauga caccgcagga     9180

ugggauacaa aaaucacacu agaagaccua aaaaaugaag agaugguaac aaaccacaug     9240

gaaggagaac acaagaaacu agccgaggcc auuuucaaac uaacguacca aaacaaggug     9300

gugcgugugc aaagaccaac accaagaggc acaguaaugg acaucauauc gagaagagac     9360

caaagaggua guggacaagu uggcaccuau ggacucaaua cuuucaccaa uauggaagcc     9420

caacuaauca gacagaugga gggagaagga gucuuuaaaa gcauucagca ccuaacaauc     9480

acagaagaaa ucgcugugca aaacugguua gcaagagugg ggcgcgaaag guuaucaaga     9540

auggccauca guggagauga uuguguugug aaaccuuuag augacagguu cgcaagcgcu     9600

uuaacagcuc uaaaugacau gggaaagauu aggaaagaca uacaacaaug ggaaccuuca     9660

agaggaugga augauuggac acaagugccc uucuguucac accauuucca ugaguuaauc     9720

augaaagacg gucgcguacu cguuguucca uguagaaacc aagaugaacu gauuggcaga     9780

gcccgaaucu cccaaggagc aggguggucu uugcgggaga cggccuguuu ggggaagucu     9840

uacgcccaaa uguggagcuu gauguacuuc cacagacgcg accucaggcu ggcggcaaau     9900

gcuauuugcu cggcaguacc aucacauugg guuccaacaa gucgaacaac cugguccaua     9960

caugcuaaac augaauggau gacaacggaa gacaugcuga cagucuggaa cagggugugg    10020

auucaagaaa acccauggau ggaagacaaa acuccagugg aaacauggga ggaaauccca    10080

uacuugggga aaagagaaga ccaauggugc ggcucauuga uuggguuaac aagcagggcc    10140

accugggcaa agaacaucca agcagcaaua aaucaaguua gaucccuuau aggcaaugaa    10200

gaauacacag auuacaugcc auccaugaaa agauucagaa gagaagagga agaagcagga    10260

guucuguggu agaaagcaaa acuaacauga aacaaggcua gaagucaggu cggauuaagc    10320

cauaguacgg aaaaaacuau gcuaccugug agccccgucc aaggacguua aaagaaguca    10380

ggccaucaua aaugccauag cuugaguaaa cuaugcagcc uguagcucca ccugagaagg    10440

uguaaaaaau ccgggaggcc acaaaccaug gaagcuguac gcauggcgua guggacuagc    10500

gguuagggga gaccccuccc uuacaaaucg cagcaacaau gggggcccaa ggcgagauga    10560

agcuguaguc ucgcuggaag gacuagaggu uagaggagac ccccccgaaa caaaaaacag    10620

cauauugacg cugggaaaga ccagagaucc ugcugucucc ucagcaucau uccaggcaca    10680

gaacgccaga aaauggaaug gugcuguuga aucaacaggu ucu                      10723


<210>  25
<211>  1983
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  prM+E VDV2

<400>  25
uuccauuuaa ccacacguaa cggagaacca cacaugaucg ucagcagaca agagaaaggg       60

aaaagucuuc uguuuaaaac agagguuggc gugaacaugu guacccucau ggccauggac      120

cuuggugaau ugugugaaga cacaaucacg uacaaguguc cccuucucag gcagaaugag      180

ccagaagaca uagacuguug gugcaacucu acguccacgu ggguaacuua ugggacgugu      240

accaccaugg gagaacauag aagagaaaaa agaucagugg cacucguucc acaugugcga      300

augggacugg agacacgaac ugaaacaugg augucaucag aaggggccug gaaacauguc      360

cagagaauug aaacuuggau cuugagacau ccaggcuuca ccaugauggc agcaauccug      420

gcauacacca uaggaacgac acauuuccaa agagcccuga uuuucaucuu acugacagcu      480

gucacuccuu caaugacaau gcguugcaua ggaaugucaa auagagacuu uguggaaggg      540

guuucaggag gaagcugggu ugacauaguc uuagaacaug gaagcugugu gacgacgaug      600

gcaaaaaaca aaccaacauu ggauuuugaa cugauaaaaa cagaagccaa acagccugcc      660

acccuaagga aguacuguau agaggcaaag cuaaccaaca caacaacaga aucucgcugc      720

ccaacacaag gggaacccag ccuaaaugaa gagcaggaca aaagguucgu cugcaaacac      780

uccaugguag acagaggaug gggaaaugga uguggacuau uuggaaaggg aggcauugug      840

accugugcua uguucagaug caaaaagaac auggaaggaa aaguugugca accagaaaac      900

uuggaauaca ccauugugau aacaccucac ucaggggaag agcaugcagu cggaaaugac      960

acaggaaaac auggcaagga aaucaaaaua acaccacaga guuccaucac agaagcagaa     1020

uugacagguu auggcacugu cacaauggag ugcucuccaa gaacgggccu cgacuucaau     1080

gagauggugu ugcugcagau ggaaaauaaa gcuuggcugg ugcacaggca augguuccua     1140

gaccugccgu uaccaugguu gcccggagcg gacacacaag agucaaauug gauacagaag     1200

gagacauugg ucacuuucaa aaauccccau gcgaagaaac aggauguugu uguuuuagga     1260

ucccaagaag gggccaugca cacagcacuu acaggggcca cagaaaucca aaugucauca     1320

ggaaacuuac ucuucacagg acaucucaag ugcaggcuga gaauggacaa gcuacagcuc     1380

aaaggaaugu cauacucuau gugcacagga aaguuuaaag uugugaagga aauagcagaa     1440

acacaacaug gaacaauagu uaucagagug caauaugaag gggacggcuc uccaugcaag     1500

aucccuuuug agauaaugga uuuggaaaaa agacaugucu uaggucgccu gauuacaguc     1560

aacccaauug ugacagaaaa agauagccca gucaacauag aagcagaacc uccauuugga     1620

gacagcuaca ucaucauagg aguagagccg ggacaacuga agcucaacug guuuaagaaa     1680

ggaaguucua ucggccaaau guuugagaca acaaugaggg gggcgaagag aauggccauu     1740

uuaggugaca cagccuggga uuuuggaucc uugggaggag uguuuacauc uauaggaaag     1800

gcucuccacc aagucuuugg agcaaucuau ggagcugccu ucaguggggu uucauggacu     1860

augaaaaucc ucauaggagu cauuaucaca uggauaggaa ugaauucacg cagcaccuca     1920

cugucuguga cacuaguauu ggugggaauu gugacacugu auuugggagu cauggugcag     1980

gcc                                                                   1983


<210>  26
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E VDV2

<400>  26

Met Arg Cys Ile Gly Met Ser Asn Arg Asp Phe Val Glu Gly Val Ser 
1               5                   10                  15      


Gly Gly Ser Trp Val Asp Ile Val Leu Glu His Gly Ser Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr 
        35                  40                  45              


Glu Ala Lys Gln Pro Ala Thr Leu Arg Lys Tyr Cys Ile Glu Ala Lys 
    50                  55                  60                  


Leu Thr Asn Thr Thr Thr Glu Ser Arg Cys Pro Thr Gln Gly Glu Pro 
65                  70                  75                  80  


Ser Leu Asn Glu Glu Gln Asp Lys Arg Phe Val Cys Lys His Ser Met 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly 
            100                 105                 110         


Ile Val Thr Cys Ala Met Phe Arg Cys Lys Lys Asn Met Glu Gly Lys 
        115                 120                 125             


Val Val Gln Pro Glu Asn Leu Glu Tyr Thr Ile Val Ile Thr Pro His 
    130                 135                 140                 


Ser Gly Glu Glu His Ala Val Gly Asn Asp Thr Gly Lys His Gly Lys 
145                 150                 155                 160 


Glu Ile Lys Ile Thr Pro Gln Ser Ser Ile Thr Glu Ala Glu Leu Thr 
                165                 170                 175     


Gly Tyr Gly Thr Val Thr Met Glu Cys Ser Pro Arg Thr Gly Leu Asp 
            180                 185                 190         


Phe Asn Glu Met Val Leu Leu Gln Met Glu Asn Lys Ala Trp Leu Val 
        195                 200                 205             


His Arg Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Leu Pro Gly Ala 
    210                 215                 220                 


Asp Thr Gln Glu Ser Asn Trp Ile Gln Lys Glu Thr Leu Val Thr Phe 
225                 230                 235                 240 


Lys Asn Pro His Ala Lys Lys Gln Asp Val Val Val Leu Gly Ser Gln 
                245                 250                 255     


Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Met 
            260                 265                 270         


Ser Ser Gly Asn Leu Leu Phe Thr Gly His Leu Lys Cys Arg Leu Arg 
        275                 280                 285             


Met Asp Lys Leu Gln Leu Lys Gly Met Ser Tyr Ser Met Cys Thr Gly 
    290                 295                 300                 


Lys Phe Lys Val Val Lys Glu Ile Ala Glu Thr Gln His Gly Thr Ile 
305                 310                 315                 320 


Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys Lys Ile Pro 
                325                 330                 335     


Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly Arg Leu Ile 
            340                 345                 350         


Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val Asn Ile Glu 
        355                 360                 365             


Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly Val Glu Pro 
    370                 375                 380                 


Gly Gln Leu Lys Leu Asn Trp Phe Lys Lys Gly Ser Ser Ile Gly Gln 
385                 390                 395                 400 


Met Phe Glu Thr Thr Met Arg Gly Ala Lys Arg Met Ala Ile Leu Gly 
                405                 410                 415     


Asp Thr Ala Trp Asp Phe Gly Ser Leu Gly Gly Val Phe Thr Ser Ile 
            420                 425                 430         


Gly Lys Ala Leu His Gln Val Phe Gly Ala Ile Tyr Gly Ala Ala Phe 
        435                 440                 445             


Ser Gly Val Ser Trp Thr Met Lys Ile Leu Ile Gly Val Ile Ile Thr 
    450                 455                 460                 


Trp Ile Gly Met Asn Ser Arg Ser Thr Ser Leu Ser Val Thr Leu Val 
465                 470                 475                 480 


Leu Val Gly Ile Val Thr Leu Tyr Leu Gly Val Met Val Gln Ala 
                485                 490                 495 


<210>  27
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M VDV2

<400>  27

Ser Val Ala Leu Val Pro His Val Arg Met Gly Leu Glu Thr Arg Thr 
1               5                   10                  15      


Glu Thr Trp Met Ser Ser Glu Gly Ala Trp Lys His Val Gln Arg Ile 
            20                  25                  30          


Glu Thr Trp Ile Leu Arg His Pro Gly Phe Thr Met Met Ala Ala Ile 
        35                  40                  45              


Leu Ala Tyr Thr Ile Gly Thr Thr His Phe Gln Arg Ala Leu Ile Phe 
    50                  55                  60                  


Ile Leu Leu Thr Ala Val Thr Pro Ser Met Thr 
65                  70                  75  
