                         SEQUENCE LISTING

<110>  GENTICEL
 
<120>  CYAA-BASED CHIMERIC PROTEINS COMPRISING A HETEROLOGOUS 
       POLYPEPTIDE AND THEIR USES IN THE INDUCTION OF IMMUNE RESPONSES

<130>  B09985A - PCT - AD/KN

<140>  PCT/EPXXXXXX
<141>  2013-07-23

<150>  EP12305897.6
<151>  2012-07-23

<160>  79    

<170>  PatentIn version 3.5

<210>  1
<211>  5121
<212>  DNA
<213>  Bordetella pertussis (wild type CyaA)


<220>
<221>  CDS
<222>  (1)..(5121)

<400>  1
atg cag caa tcg cat cag gct ggt tac gca aac gcc gcc gac cgg gag         48
Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu           
1               5                   10                  15                

tct ggc atc ccc gca gcc gta ctc gat ggc atc aag gcc gtg gcg aag         96
Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys           
            20                  25                  30                    

gaa aaa aac gcc aca ttg atg ttc cgc ctg gtc aac ccc cat tcc acc        144
Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr           
        35                  40                  45                        

agc ctg att gcc gaa ggg gtg gcc acc aaa gga ttg ggc gtg cac gcc        192
Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala           
    50                  55                  60                            

aag tcg tcc gat tgg ggg ttg cag gcg ggc tac att ccc gtc aac ccg        240
Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro           
65                  70                  75                  80            

aat ctt tcc aaa ctg ttc ggc cgt gcg ccc gag gtg atc gcg cgg gcc        288
Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala           
                85                  90                  95                

gac aac gac gtc aac agc agc ctg gcg cat ggc cat acc gcg gtc gac        336
Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp           
            100                 105                 110                   

ctg acg ctg tcg aaa gag cgg ctt gac tat ctg cgg caa gcg ggc ctg        384
Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu           
        115                 120                 125                       

gtc acc ggc atg gcc gat ggc gtg gtc gcg agc aac cac gca ggc tac        432
Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr           
    130                 135                 140                           

gag cag ttc gag ttt cgc gtg aag gaa acc tcg gac ggg cgc tat gcc        480
Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala           
145                 150                 155                 160           

gtg cag tat cgc cgc aag ggc ggc gac gat ttc gag gcg gtc aag gtg        528
Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val           
                165                 170                 175               

atc ggc aat gcc gcc ggt att cca ctg acg gcg gat atc gac atg ttc        576
Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe           
            180                 185                 190                   

gcc att atg ccg cat ctg tcc aac ttc cgc gac tcg gcg cgc agt tcg        624
Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser           
        195                 200                 205                       

gtg acc agc ggc gat tcg gtg acc gat tac ctg gcg cgc acg cgg cgg        672
Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg           
    210                 215                 220                           

gcc gcc agc gag gcc acg ggc ggc ctg gat cgc gaa cgc atc gac ttg        720
Ala Ala Ser Glu Ala Thr Gly Gly Leu Asp Arg Glu Arg Ile Asp Leu           
225                 230                 235                 240           

ttg tgg aaa atc gct cgc gcc ggc gcc cgt tcc gca gtg ggc acc gag        768
Leu Trp Lys Ile Ala Arg Ala Gly Ala Arg Ser Ala Val Gly Thr Glu           
                245                 250                 255               

gcg cgt cgc cag ttc cgc tac gac ggc gac atg aat atc ggc gtg atc        816
Ala Arg Arg Gln Phe Arg Tyr Asp Gly Asp Met Asn Ile Gly Val Ile           
            260                 265                 270                   

acc gat ttc gag ctg gaa gtg cgc aat gcg ctg aac agg cgg gcg cac        864
Thr Asp Phe Glu Leu Glu Val Arg Asn Ala Leu Asn Arg Arg Ala His           
        275                 280                 285                       

gcc gtc ggc gcg cag gac gtg gtc cag cat ggc act gag cag aac aat        912
Ala Val Gly Ala Gln Asp Val Val Gln His Gly Thr Glu Gln Asn Asn           
    290                 295                 300                           

cct ttc ccg gag gca gat gag aag att ttc gtc gta tcg gcc acc ggt        960
Pro Phe Pro Glu Ala Asp Glu Lys Ile Phe Val Val Ser Ala Thr Gly           
305                 310                 315                 320           

gaa agc cag atg ctc acg cgc ggg caa ctg aag gaa tac att ggc cag       1008
Glu Ser Gln Met Leu Thr Arg Gly Gln Leu Lys Glu Tyr Ile Gly Gln           
                325                 330                 335               

cag cgc ggc gag ggc tat gtc ttc tac gag aac cgt gca tac ggc gtg       1056
Gln Arg Gly Glu Gly Tyr Val Phe Tyr Glu Asn Arg Ala Tyr Gly Val           
            340                 345                 350                   

gcg ggg aaa agc ctg ttc gac gat ggg ctg gga gcc gcg ccc ggc gtg       1104
Ala Gly Lys Ser Leu Phe Asp Asp Gly Leu Gly Ala Ala Pro Gly Val           
        355                 360                 365                       

ccg agc gga cgt tcg aag ttc tcg ccg gat gta ctg gaa acg gtg ccg       1152
Pro Ser Gly Arg Ser Lys Phe Ser Pro Asp Val Leu Glu Thr Val Pro           
    370                 375                 380                           

gcg tca ccc gga ttg cgg cgg ccg tcg ctg ggc gca gtg gaa cgc cag       1200
Ala Ser Pro Gly Leu Arg Arg Pro Ser Leu Gly Ala Val Glu Arg Gln           
385                 390                 395                 400           

gat tcc ggc tat gac agc ctt gat ggg gtg gga tcg cga tcg ttc tcg       1248
Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly Ser Arg Ser Phe Ser           
                405                 410                 415               

ttg ggc gag gtg tcc gac atg gcc gcc gtg gaa gcg gcg gaa ctg gaa       1296
Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu Ala Ala Glu Leu Glu           
            420                 425                 430                   

atg acc cgg caa gtc ttg cac gcc ggg gcg cgg cag gac gat gcc gag       1344
Met Thr Arg Gln Val Leu His Ala Gly Ala Arg Gln Asp Asp Ala Glu           
        435                 440                 445                       

ccg ggc gtg agc ggt gcg tcg gcg cac tgg ggg cag cgg gcg ctg cag       1392
Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly Gln Arg Ala Leu Gln           
    450                 455                 460                           

ggc gcc cag gcg gtg gcg gcg gcg cag cgg ctg gtt cat gcc att gcc       1440
Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu Val His Ala Ile Ala           
465                 470                 475                 480           

ctg atg acg caa ttc ggc cgg gcc ggt tcc acc aac acg ccg cag gaa       1488
Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr Asn Thr Pro Gln Glu           
                485                 490                 495               

gcg gcc tcg ttg tcg gcg gcc gtg ttc ggc ttg ggc gag gcc agc agc       1536
Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu Gly Glu Ala Ser Ser           
            500                 505                 510                   

gcc gtg gcc gaa acc gtg agc ggt ttt ttc cgc ggg tct tcg cgc tgg       1584
Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg Gly Ser Ser Arg Trp           
        515                 520                 525                       

gcc ggc ggt ttc ggc gtg gct ggc ggc gcg atg gcg ctg gga ggc ggc       1632
Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met Ala Leu Gly Gly Gly           
    530                 535                 540                           

atc gcc gcg gcc gtt ggc gcc ggg atg tcg ttg acc gat gac gcg ccg       1680
Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu Thr Asp Asp Ala Pro           
545                 550                 555                 560           

gcc gga cag aag gcc gcc gcc ggc gcc gag atc gcg ctg cag ttg aca       1728
Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile Ala Leu Gln Leu Thr           
                565                 570                 575               

ggt gga acg gtc gag ctg gct tct tcc atc gcg ttg gcg ctg gcc gcg       1776
Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu Ala Leu Ala Ala           
            580                 585                 590                   

gcg cgc ggc gtg acc agc ggc ttg cag gtg gcc ggg gcg tcg gcc ggg       1824
Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly Ala Ser Ala Gly           
        595                 600                 605                       

gcg gct gcc ggc gca ttg gcc gcg gcg ctc agt ccc atg gag atc tac       1872
Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro Met Glu Ile Tyr           
    610                 615                 620                           

ggc ctg gtg cag caa tcg cac tat gcg gat cag ctg gac aag ctg gcg       1920
Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu Asp Lys Leu Ala           
625                 630                 635                 640           

cag gaa tcg agc gca tac ggt tac gag ggc gac gcc ttg ctg gcc cag       1968
Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala Leu Leu Ala Gln           
                645                 650                 655               

ctg tat cgc gac aag acg gcc gcc gag ggc gcc gtc gcc ggc gtc tcc       2016
Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val Ala Gly Val Ser           
            660                 665                 670                   

gcc gtc ctg agc acg gtg ggg gcg gcg gtg tcg atc gcc gcg gcg gcc       2064
Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile Ala Ala Ala Ala           
        675                 680                 685                       

agc gtg gta ggg gcc ccg gtg gcg gtg gtc act tcc ttg ctg acc ggg       2112
Ser Val Val Gly Ala Pro Val Ala Val Val Thr Ser Leu Leu Thr Gly           
    690                 695                 700                           

gct ctc aac ggc atc ctg cgc ggc gtg cag cag ccc atc atc gaa aag       2160
Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro Ile Ile Glu Lys           
705                 710                 715                 720           

ctg gcc aac gat tac gct cgc aag atc gac gag ctg ggc ggg ccg caa       2208
Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu Gly Gly Pro Gln           
                725                 730                 735               

gcg tac ttc gag aaa aac ctg cag gcg cgt cac gaa caa ctg gcc aat       2256
Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu Gln Leu Ala Asn           
            740                 745                 750                   

tcg gac ggc cta cgg aaa atg ctg gcc gac ctg cag gcc ggt tgg aac       2304
Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln Ala Gly Trp Asn           
        755                 760                 765                       

gcc agc agc gtg atc ggg gtg cag acg aca gag atc tcc aag tcg gcg       2352
Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile Ser Lys Ser Ala           
    770                 775                 780                           

ctc gaa ctg gcc gcc att acc ggc aac gcg gac aac ctg aaa tcc gtc       2400
Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn Leu Lys Ser Val           
785                 790                 795                 800           

gac gtg ttc gtg gac cgc ttc gtc cag ggc gag cgg gtg gcc ggc cag       2448
Asp Val Phe Val Asp Arg Phe Val Gln Gly Glu Arg Val Ala Gly Gln           
                805                 810                 815               

ccg gtg gtc ctc gac gtc gcc gcc ggc ggc atc gat atc gcc agc cgc       2496
Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp Ile Ala Ser Arg           
            820                 825                 830                   

aag ggc gag cgg ccg gcg ctg acg ttc atc acg ccg ctg gcc gcg cca       2544
Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro Leu Ala Ala Pro           
        835                 840                 845                       

gga gaa gag cag cgc cgg cgc acg aaa acg ggc aag agc gaa ttc acc       2592
Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys Ser Glu Phe Thr           
    850                 855                 860                           

aca ttc gtc gag atc gtg ggc aag cag gac cgc tgg cgc atc cgg gac       2640
Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp Arg Ile Arg Asp           
865                 870                 875                 880           

ggc gcg gcc gac acc acc atc gat ctg gcc aag gtg gtg tcg caa ctg       2688
Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val Val Ser Gln Leu           
                885                 890                 895               

gtc gac gcc aat ggc gtg ctc aag cac agc atc aaa ctg gat gtg atc       2736
Val Asp Ala Asn Gly Val Leu Lys His Ser Ile Lys Leu Asp Val Ile           
            900                 905                 910                   

ggc gga gat ggc gat gac gtc gtg ctt gcc aat gct tcg cgc atc cat       2784
Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn Ala Ser Arg Ile His           
        915                 920                 925                       

tat gac ggc ggc gcg ggc acc aac acg gtc agc tat gcc gcc ctg ggt       2832
Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser Tyr Ala Ala Leu Gly           
    930                 935                 940                           

cga cag gat tcc att acc gtg tcc gcc gac ggg gaa cgt ttc aac gtg       2880
Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly Glu Arg Phe Asn Val           
945                 950                 955                 960           

cgc aag cag ttg aac aac gcc aac gtg tat cgc gaa ggc gtg gct acc       2928
Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg Glu Gly Val Ala Thr           
                965                 970                 975               

cag aca acc gcc tac ggc aag cgc acg gag aat gtc caa tac cgc cat       2976
Gln Thr Thr Ala Tyr Gly Lys Arg Thr Glu Asn Val Gln Tyr Arg His           
            980                 985                 990                   

gtc gag ctg gcc cgt gtc ggg caa  ctg gtg gag gtc gac  acg ctc gag     3024
Val Glu Leu Ala Arg Val Gly Gln  Leu Val Glu Val Asp  Thr Leu Glu         
        995                 1000                 1005                     

cat gtg  cag cac atc atc ggc  ggg gcc ggc aac gat  tcg atc acc        3069
His Val  Gln His Ile Ile Gly  Gly Ala Gly Asn Asp  Ser Ile Thr            
    1010                 1015                 1020                        

ggc aat  gcg cac gac aac ttc  cta gcc ggc ggg tcg  ggc gac gac        3114
Gly Asn  Ala His Asp Asn Phe  Leu Ala Gly Gly Ser  Gly Asp Asp            
    1025                 1030                 1035                        

agg ctg  gat ggc ggc gcc ggc  aac gac acc ctg gtt  ggc ggc gag        3159
Arg Leu  Asp Gly Gly Ala Gly  Asn Asp Thr Leu Val  Gly Gly Glu            
    1040                 1045                 1050                        

ggc caa  aac acg gtc atc ggc  ggc gcc ggc gac gac  gta ttc ctg        3204
Gly Gln  Asn Thr Val Ile Gly  Gly Ala Gly Asp Asp  Val Phe Leu            
    1055                 1060                 1065                        

cag gac  ctg ggg gta tgg agc  aac cag ctc gat ggc  ggc gcg ggc        3249
Gln Asp  Leu Gly Val Trp Ser  Asn Gln Leu Asp Gly  Gly Ala Gly            
    1070                 1075                 1080                        

gtc gat  acc gtg aag tac aac  gtg cac cag cct tcc  gag gag cgc        3294
Val Asp  Thr Val Lys Tyr Asn  Val His Gln Pro Ser  Glu Glu Arg            
    1085                 1090                 1095                        

ctc gaa  cgc atg ggc gac acg  ggc atc cat gcc gat  ctt caa aag        3339
Leu Glu  Arg Met Gly Asp Thr  Gly Ile His Ala Asp  Leu Gln Lys            
    1100                 1105                 1110                        

ggc acg  gtc gag aag tgg ccg  gcc ctg aac ctg ttc  agc gtc gac        3384
Gly Thr  Val Glu Lys Trp Pro  Ala Leu Asn Leu Phe  Ser Val Asp            
    1115                 1120                 1125                        

cat gtc  aag aat atc gag aat  ctg cac ggc tcc cgc  ctg aac gac        3429
His Val  Lys Asn Ile Glu Asn  Leu His Gly Ser Arg  Leu Asn Asp            
    1130                 1135                 1140                        

cgc atc  gcc ggc gac gac cag  gac aac gag ctc tgg  ggc cac gat        3474
Arg Ile  Ala Gly Asp Asp Gln  Asp Asn Glu Leu Trp  Gly His Asp            
    1145                 1150                 1155                        

ggc aac  gac acg ata cgc ggc  cgg ggc ggc gac gac  atc ctg cgc        3519
Gly Asn  Asp Thr Ile Arg Gly  Arg Gly Gly Asp Asp  Ile Leu Arg            
    1160                 1165                 1170                        

ggc ggc  ctg ggc ctg gac acg  ctg tat ggc gag gac  ggc aac gac        3564
Gly Gly  Leu Gly Leu Asp Thr  Leu Tyr Gly Glu Asp  Gly Asn Asp            
    1175                 1180                 1185                        

atc ttc  ctg cag gac gac gag  acc gtc agc gat gac  atc gac ggc        3609
Ile Phe  Leu Gln Asp Asp Glu  Thr Val Ser Asp Asp  Ile Asp Gly            
    1190                 1195                 1200                        

ggc gcg  ggg ctg gac acc gtc  gac tac tcc gcc atg  atc cat cca        3654
Gly Ala  Gly Leu Asp Thr Val  Asp Tyr Ser Ala Met  Ile His Pro            
    1205                 1210                 1215                        

ggc agg  atc gtt gcg ccg cat  gaa tac ggc ttc ggg  atc gag gcg        3699
Gly Arg  Ile Val Ala Pro His  Glu Tyr Gly Phe Gly  Ile Glu Ala            
    1220                 1225                 1230                        

gac ctg  tcc agg gaa tgg gtg  cgc aag gcg tcc gcg  ctg ggc gtg        3744
Asp Leu  Ser Arg Glu Trp Val  Arg Lys Ala Ser Ala  Leu Gly Val            
    1235                 1240                 1245                        

gac tat  tac gat aat gtc cgc  aat gtc gaa aac gtc  atc ggt acg        3789
Asp Tyr  Tyr Asp Asn Val Arg  Asn Val Glu Asn Val  Ile Gly Thr            
    1250                 1255                 1260                        

agc atg  aag gat gtg ctc atc  ggc gac gcg caa gcc  aat acc ctg        3834
Ser Met  Lys Asp Val Leu Ile  Gly Asp Ala Gln Ala  Asn Thr Leu            
    1265                 1270                 1275                        

atg ggc  cag ggc ggc gac gat  acc gtg cgc ggc ggc  gac ggc gat        3879
Met Gly  Gln Gly Gly Asp Asp  Thr Val Arg Gly Gly  Asp Gly Asp            
    1280                 1285                 1290                        

gat ctg  ctg ttc ggc ggc gac  ggc aac gac atg ctg  tat ggc gac        3924
Asp Leu  Leu Phe Gly Gly Asp  Gly Asn Asp Met Leu  Tyr Gly Asp            
    1295                 1300                 1305                        

gcc ggc  aac gac acc ctc tac  ggg ggg ctg ggc gac  gat acc ctt        3969
Ala Gly  Asn Asp Thr Leu Tyr  Gly Gly Leu Gly Asp  Asp Thr Leu            
    1310                 1315                 1320                        

gaa ggc  ggc gcg ggc aac gat  tgg ttc ggc cag acg  cag gcg cgc        4014
Glu Gly  Gly Ala Gly Asn Asp  Trp Phe Gly Gln Thr  Gln Ala Arg            
    1325                 1330                 1335                        

gag cat  gac gtg ctg cgc ggc  gga gat ggg gtg gat  acc gtc gat        4059
Glu His  Asp Val Leu Arg Gly  Gly Asp Gly Val Asp  Thr Val Asp            
    1340                 1345                 1350                        

tac agc  cag acc ggc gcg cat  gcc ggc att gcc gcg  ggt cgc atc        4104
Tyr Ser  Gln Thr Gly Ala His  Ala Gly Ile Ala Ala  Gly Arg Ile            
    1355                 1360                 1365                        

ggg ctg  ggc atc ctg gct gac  ctg ggc gcc ggc cgc  gtc gac aag        4149
Gly Leu  Gly Ile Leu Ala Asp  Leu Gly Ala Gly Arg  Val Asp Lys            
    1370                 1375                 1380                        

ctg ggc  gag gcc ggc agc agc  gcc tac gat acg gtt  tcc ggt atc        4194
Leu Gly  Glu Ala Gly Ser Ser  Ala Tyr Asp Thr Val  Ser Gly Ile            
    1385                 1390                 1395                        

gag aac  gtg gtg ggc acg gaa  ctg gcc gac cgc atc  acg ggc gat        4239
Glu Asn  Val Val Gly Thr Glu  Leu Ala Asp Arg Ile  Thr Gly Asp            
    1400                 1405                 1410                        

gcg cag  gcc aac gtg ctg cgc  ggc gcg ggt ggc gcc  gac gtg ctt        4284
Ala Gln  Ala Asn Val Leu Arg  Gly Ala Gly Gly Ala  Asp Val Leu            
    1415                 1420                 1425                        

gcg ggc  ggc gag ggc gac gat  gtg ctg ctg ggc ggc  gac ggc gac        4329
Ala Gly  Gly Glu Gly Asp Asp  Val Leu Leu Gly Gly  Asp Gly Asp            
    1430                 1435                 1440                        

gac cag  ctg tcg ggc gac gcc  gga cgc gat cgc ttg  tac ggc gaa        4374
Asp Gln  Leu Ser Gly Asp Ala  Gly Arg Asp Arg Leu  Tyr Gly Glu            
    1445                 1450                 1455                        

gcc ggt  gac gac tgg ttc ttc  cag gat gcc gcc aat  gcc ggc aat        4419
Ala Gly  Asp Asp Trp Phe Phe  Gln Asp Ala Ala Asn  Ala Gly Asn            
    1460                 1465                 1470                        

ctg ctc  gac ggc ggc gac ggc  cgc gat acc gtg gat  ttc agc ggc        4464
Leu Leu  Asp Gly Gly Asp Gly  Arg Asp Thr Val Asp  Phe Ser Gly            
    1475                 1480                 1485                        

ccg ggc  cgg ggc ctc gac gcc  ggc gca aag ggc gta  ttc ctg agc        4509
Pro Gly  Arg Gly Leu Asp Ala  Gly Ala Lys Gly Val  Phe Leu Ser            
    1490                 1495                 1500                        

ttg ggc  aag ggg ttc gcc agc  ctg atg gac gaa ccc  gaa acc agc        4554
Leu Gly  Lys Gly Phe Ala Ser  Leu Met Asp Glu Pro  Glu Thr Ser            
    1505                 1510                 1515                        

aac gtg  ttg cgc aat atc gag  aac gcc gtg ggc agc  gcg cgt gat        4599
Asn Val  Leu Arg Asn Ile Glu  Asn Ala Val Gly Ser  Ala Arg Asp            
    1520                 1525                 1530                        

gac gtg  ctg atc ggc gac gca  ggc gcc aac gtc ctc  aat ggc ctg        4644
Asp Val  Leu Ile Gly Asp Ala  Gly Ala Asn Val Leu  Asn Gly Leu            
    1535                 1540                 1545                        

gcg ggc  aac gac gtg ctg tcc  ggc ggc gct ggc gac  gat gtg ctg        4689
Ala Gly  Asn Asp Val Leu Ser  Gly Gly Ala Gly Asp  Asp Val Leu            
    1550                 1555                 1560                        

ctg ggc  gac gag ggc tcg gac  ctg ctc agc ggc gat  gcg ggc aac        4734
Leu Gly  Asp Glu Gly Ser Asp  Leu Leu Ser Gly Asp  Ala Gly Asn            
    1565                 1570                 1575                        

gac gat  ctg ttc ggc ggg cag  ggc gat gat act tat  ctg ttc ggg        4779
Asp Asp  Leu Phe Gly Gly Gln  Gly Asp Asp Thr Tyr  Leu Phe Gly            
    1580                 1585                 1590                        

gtc ggg  tac ggg cac gac acg  atc tac gaa tcg ggc  ggc ggc cat        4824
Val Gly  Tyr Gly His Asp Thr  Ile Tyr Glu Ser Gly  Gly Gly His            
    1595                 1600                 1605                        

gac acc  atc cgc atc aac gcg  ggg gcg gac cag ctg  tgg ttc gcg        4869
Asp Thr  Ile Arg Ile Asn Ala  Gly Ala Asp Gln Leu  Trp Phe Ala            
    1610                 1615                 1620                        

cgc cag  ggc aac gac ctg gag  atc cgc att ctc ggc  acc gac gat        4914
Arg Gln  Gly Asn Asp Leu Glu  Ile Arg Ile Leu Gly  Thr Asp Asp            
    1625                 1630                 1635                        

gca ctt  acc gtg cac gac tgg  tat cgc gac gcc gat  cac cgg gtg        4959
Ala Leu  Thr Val His Asp Trp  Tyr Arg Asp Ala Asp  His Arg Val            
    1640                 1645                 1650                        

gaa atc  atc cat gcc gcc aac  cag gcg gta gac cag  gca ggc atc        5004
Glu Ile  Ile His Ala Ala Asn  Gln Ala Val Asp Gln  Ala Gly Ile            
    1655                 1660                 1665                        

gaa aag  ctg gtc gag gca atg  gcg cag tat ccg gac  ccc ggc gcg        5049
Glu Lys  Leu Val Glu Ala Met  Ala Gln Tyr Pro Asp  Pro Gly Ala            
    1670                 1675                 1680                        

gcg gcg  gct gcc ccg ccg gcg  gcg cgc gtg ccg gac  acg ctg atg        5094
Ala Ala  Ala Ala Pro Pro Ala  Ala Arg Val Pro Asp  Thr Leu Met            
    1685                 1690                 1695                        

cag tcc  ctg gct gtc aac tgg  cgc tga                                 5121
Gln Ser  Leu Ala Val Asn Trp  Arg                                         
    1700                 1705                                             


<210>  2
<211>  1706
<212>  PRT
<213>  Bordetella pertussis (wild type CyaA)

<400>  2

Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu 
1               5                   10                  15      


Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys 
            20                  25                  30          


Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr 
        35                  40                  45              


Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala 
    50                  55                  60                  


Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro 
65                  70                  75                  80  


Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala 
                85                  90                  95      


Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp 
            100                 105                 110         


Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu 
        115                 120                 125             


Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr 
    130                 135                 140                 


Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala 
145                 150                 155                 160 


Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val 
                165                 170                 175     


Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe 
            180                 185                 190         


Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser 
        195                 200                 205             


Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg 
    210                 215                 220                 


Ala Ala Ser Glu Ala Thr Gly Gly Leu Asp Arg Glu Arg Ile Asp Leu 
225                 230                 235                 240 


Leu Trp Lys Ile Ala Arg Ala Gly Ala Arg Ser Ala Val Gly Thr Glu 
                245                 250                 255     


Ala Arg Arg Gln Phe Arg Tyr Asp Gly Asp Met Asn Ile Gly Val Ile 
            260                 265                 270         


Thr Asp Phe Glu Leu Glu Val Arg Asn Ala Leu Asn Arg Arg Ala His 
        275                 280                 285             


Ala Val Gly Ala Gln Asp Val Val Gln His Gly Thr Glu Gln Asn Asn 
    290                 295                 300                 


Pro Phe Pro Glu Ala Asp Glu Lys Ile Phe Val Val Ser Ala Thr Gly 
305                 310                 315                 320 


Glu Ser Gln Met Leu Thr Arg Gly Gln Leu Lys Glu Tyr Ile Gly Gln 
                325                 330                 335     


Gln Arg Gly Glu Gly Tyr Val Phe Tyr Glu Asn Arg Ala Tyr Gly Val 
            340                 345                 350         


Ala Gly Lys Ser Leu Phe Asp Asp Gly Leu Gly Ala Ala Pro Gly Val 
        355                 360                 365             


Pro Ser Gly Arg Ser Lys Phe Ser Pro Asp Val Leu Glu Thr Val Pro 
    370                 375                 380                 


Ala Ser Pro Gly Leu Arg Arg Pro Ser Leu Gly Ala Val Glu Arg Gln 
385                 390                 395                 400 


Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly Ser Arg Ser Phe Ser 
                405                 410                 415     


Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu Ala Ala Glu Leu Glu 
            420                 425                 430         


Met Thr Arg Gln Val Leu His Ala Gly Ala Arg Gln Asp Asp Ala Glu 
        435                 440                 445             


Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly Gln Arg Ala Leu Gln 
    450                 455                 460                 


Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu Val His Ala Ile Ala 
465                 470                 475                 480 


Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr Asn Thr Pro Gln Glu 
                485                 490                 495     


Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu Gly Glu Ala Ser Ser 
            500                 505                 510         


Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg Gly Ser Ser Arg Trp 
        515                 520                 525             


Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met Ala Leu Gly Gly Gly 
    530                 535                 540                 


Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu Thr Asp Asp Ala Pro 
545                 550                 555                 560 


Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile Ala Leu Gln Leu Thr 
                565                 570                 575     


Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu Ala Leu Ala Ala 
            580                 585                 590         


Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly Ala Ser Ala Gly 
        595                 600                 605             


Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro Met Glu Ile Tyr 
    610                 615                 620                 


Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu Asp Lys Leu Ala 
625                 630                 635                 640 


Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala Leu Leu Ala Gln 
                645                 650                 655     


Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val Ala Gly Val Ser 
            660                 665                 670         


Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile Ala Ala Ala Ala 
        675                 680                 685             


Ser Val Val Gly Ala Pro Val Ala Val Val Thr Ser Leu Leu Thr Gly 
    690                 695                 700                 


Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro Ile Ile Glu Lys 
705                 710                 715                 720 


Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu Gly Gly Pro Gln 
                725                 730                 735     


Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu Gln Leu Ala Asn 
            740                 745                 750         


Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln Ala Gly Trp Asn 
        755                 760                 765             


Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile Ser Lys Ser Ala 
    770                 775                 780                 


Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn Leu Lys Ser Val 
785                 790                 795                 800 


Asp Val Phe Val Asp Arg Phe Val Gln Gly Glu Arg Val Ala Gly Gln 
                805                 810                 815     


Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp Ile Ala Ser Arg 
            820                 825                 830         


Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro Leu Ala Ala Pro 
        835                 840                 845             


Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys Ser Glu Phe Thr 
    850                 855                 860                 


Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp Arg Ile Arg Asp 
865                 870                 875                 880 


Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val Val Ser Gln Leu 
                885                 890                 895     


Val Asp Ala Asn Gly Val Leu Lys His Ser Ile Lys Leu Asp Val Ile 
            900                 905                 910         


Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn Ala Ser Arg Ile His 
        915                 920                 925             


Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser Tyr Ala Ala Leu Gly 
    930                 935                 940                 


Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly Glu Arg Phe Asn Val 
945                 950                 955                 960 


Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg Glu Gly Val Ala Thr 
                965                 970                 975     


Gln Thr Thr Ala Tyr Gly Lys Arg Thr Glu Asn Val Gln Tyr Arg His 
            980                 985                 990         


Val Glu Leu Ala Arg Val Gly Gln  Leu Val Glu Val Asp  Thr Leu Glu 
        995                 1000                 1005             


His Val  Gln His Ile Ile Gly  Gly Ala Gly Asn Asp  Ser Ile Thr 
    1010                 1015                 1020             


Gly Asn  Ala His Asp Asn Phe  Leu Ala Gly Gly Ser  Gly Asp Asp 
    1025                 1030                 1035             


Arg Leu  Asp Gly Gly Ala Gly  Asn Asp Thr Leu Val  Gly Gly Glu 
    1040                 1045                 1050             


Gly Gln  Asn Thr Val Ile Gly  Gly Ala Gly Asp Asp  Val Phe Leu 
    1055                 1060                 1065             


Gln Asp  Leu Gly Val Trp Ser  Asn Gln Leu Asp Gly  Gly Ala Gly 
    1070                 1075                 1080             


Val Asp  Thr Val Lys Tyr Asn  Val His Gln Pro Ser  Glu Glu Arg 
    1085                 1090                 1095             


Leu Glu  Arg Met Gly Asp Thr  Gly Ile His Ala Asp  Leu Gln Lys 
    1100                 1105                 1110             


Gly Thr  Val Glu Lys Trp Pro  Ala Leu Asn Leu Phe  Ser Val Asp 
    1115                 1120                 1125             


His Val  Lys Asn Ile Glu Asn  Leu His Gly Ser Arg  Leu Asn Asp 
    1130                 1135                 1140             


Arg Ile  Ala Gly Asp Asp Gln  Asp Asn Glu Leu Trp  Gly His Asp 
    1145                 1150                 1155             


Gly Asn  Asp Thr Ile Arg Gly  Arg Gly Gly Asp Asp  Ile Leu Arg 
    1160                 1165                 1170             


Gly Gly  Leu Gly Leu Asp Thr  Leu Tyr Gly Glu Asp  Gly Asn Asp 
    1175                 1180                 1185             


Ile Phe  Leu Gln Asp Asp Glu  Thr Val Ser Asp Asp  Ile Asp Gly 
    1190                 1195                 1200             


Gly Ala  Gly Leu Asp Thr Val  Asp Tyr Ser Ala Met  Ile His Pro 
    1205                 1210                 1215             


Gly Arg  Ile Val Ala Pro His  Glu Tyr Gly Phe Gly  Ile Glu Ala 
    1220                 1225                 1230             


Asp Leu  Ser Arg Glu Trp Val  Arg Lys Ala Ser Ala  Leu Gly Val 
    1235                 1240                 1245             


Asp Tyr  Tyr Asp Asn Val Arg  Asn Val Glu Asn Val  Ile Gly Thr 
    1250                 1255                 1260             


Ser Met  Lys Asp Val Leu Ile  Gly Asp Ala Gln Ala  Asn Thr Leu 
    1265                 1270                 1275             


Met Gly  Gln Gly Gly Asp Asp  Thr Val Arg Gly Gly  Asp Gly Asp 
    1280                 1285                 1290             


Asp Leu  Leu Phe Gly Gly Asp  Gly Asn Asp Met Leu  Tyr Gly Asp 
    1295                 1300                 1305             


Ala Gly  Asn Asp Thr Leu Tyr  Gly Gly Leu Gly Asp  Asp Thr Leu 
    1310                 1315                 1320             


Glu Gly  Gly Ala Gly Asn Asp  Trp Phe Gly Gln Thr  Gln Ala Arg 
    1325                 1330                 1335             


Glu His  Asp Val Leu Arg Gly  Gly Asp Gly Val Asp  Thr Val Asp 
    1340                 1345                 1350             


Tyr Ser  Gln Thr Gly Ala His  Ala Gly Ile Ala Ala  Gly Arg Ile 
    1355                 1360                 1365             


Gly Leu  Gly Ile Leu Ala Asp  Leu Gly Ala Gly Arg  Val Asp Lys 
    1370                 1375                 1380             


Leu Gly  Glu Ala Gly Ser Ser  Ala Tyr Asp Thr Val  Ser Gly Ile 
    1385                 1390                 1395             


Glu Asn  Val Val Gly Thr Glu  Leu Ala Asp Arg Ile  Thr Gly Asp 
    1400                 1405                 1410             


Ala Gln  Ala Asn Val Leu Arg  Gly Ala Gly Gly Ala  Asp Val Leu 
    1415                 1420                 1425             


Ala Gly  Gly Glu Gly Asp Asp  Val Leu Leu Gly Gly  Asp Gly Asp 
    1430                 1435                 1440             


Asp Gln  Leu Ser Gly Asp Ala  Gly Arg Asp Arg Leu  Tyr Gly Glu 
    1445                 1450                 1455             


Ala Gly  Asp Asp Trp Phe Phe  Gln Asp Ala Ala Asn  Ala Gly Asn 
    1460                 1465                 1470             


Leu Leu  Asp Gly Gly Asp Gly  Arg Asp Thr Val Asp  Phe Ser Gly 
    1475                 1480                 1485             


Pro Gly  Arg Gly Leu Asp Ala  Gly Ala Lys Gly Val  Phe Leu Ser 
    1490                 1495                 1500             


Leu Gly  Lys Gly Phe Ala Ser  Leu Met Asp Glu Pro  Glu Thr Ser 
    1505                 1510                 1515             


Asn Val  Leu Arg Asn Ile Glu  Asn Ala Val Gly Ser  Ala Arg Asp 
    1520                 1525                 1530             


Asp Val  Leu Ile Gly Asp Ala  Gly Ala Asn Val Leu  Asn Gly Leu 
    1535                 1540                 1545             


Ala Gly  Asn Asp Val Leu Ser  Gly Gly Ala Gly Asp  Asp Val Leu 
    1550                 1555                 1560             


Leu Gly  Asp Glu Gly Ser Asp  Leu Leu Ser Gly Asp  Ala Gly Asn 
    1565                 1570                 1575             


Asp Asp  Leu Phe Gly Gly Gln  Gly Asp Asp Thr Tyr  Leu Phe Gly 
    1580                 1585                 1590             


Val Gly  Tyr Gly His Asp Thr  Ile Tyr Glu Ser Gly  Gly Gly His 
    1595                 1600                 1605             


Asp Thr  Ile Arg Ile Asn Ala  Gly Ala Asp Gln Leu  Trp Phe Ala 
    1610                 1615                 1620             


Arg Gln  Gly Asn Asp Leu Glu  Ile Arg Ile Leu Gly  Thr Asp Asp 
    1625                 1630                 1635             


Ala Leu  Thr Val His Asp Trp  Tyr Arg Asp Ala Asp  His Arg Val 
    1640                 1645                 1650             


Glu Ile  Ile His Ala Ala Asn  Gln Ala Val Asp Gln  Ala Gly Ile 
    1655                 1660                 1665             


Glu Lys  Leu Val Glu Ala Met  Ala Gln Tyr Pro Asp  Pro Gly Ala 
    1670                 1675                 1680             


Ala Ala  Ala Ala Pro Pro Ala  Ala Arg Val Pro Asp  Thr Leu Met 
    1685                 1690                 1695             


Gln Ser  Leu Ala Val Asn Trp  Arg 
    1700                 1705     


<210>  3
<211>  5121
<212>  DNA
<213>  Bordetella hinzii (wild type CyaA)


<220>
<221>  CDS
<222>  (1)..(5121)

<400>  3
atg cag caa tcg cat cag gct ggt tac gca aac gcc gcc gac cgg gag         48
Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu           
1               5                   10                  15                

tct ggc atc ccc gca gcc gta ctc gat ggc atc aag gcc gtg gcg aag         96
Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys           
            20                  25                  30                    

gaa aaa aac gcc aca ttg atg ttc cgc ctg gtc aac ccc cat tcc acc        144
Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr           
        35                  40                  45                        

agc ctg att gcc gaa ggg gtg gcc acc aaa gga ttg ggc gtg cac gcc        192
Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala           
    50                  55                  60                            

aag tcg tcc gat tgg ggg ttg cag gcg ggc tac att ccc gtc aac ccg        240
Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro           
65                  70                  75                  80            

aat ctt tcc aaa ctg ttc ggc cgt gcg ccc gag gtg atc gcg cgg gcc        288
Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala           
                85                  90                  95                

gac aac gac gtc aac agc agc ctg gcg cat ggc cat acc gcg gtc gac        336
Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp           
            100                 105                 110                   

ctg acg ctg tcg aaa gag cgg ctt gac tat ctg cgg caa gcg ggc ctg        384
Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu           
        115                 120                 125                       

gtc acc ggc atg gcc gat ggc gtg gtc gcg agc aac cac gca ggc tac        432
Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr           
    130                 135                 140                           

gag cag ttc gag ttt cgc gtg aag gaa acc tcg gac ggg cgc tat gcc        480
Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala           
145                 150                 155                 160           

gtg cag tat cgc cgc aag ggc ggc gac gat ttc gag gcg gtc aag gtg        528
Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val           
                165                 170                 175               

atc ggc aat gcc gcc ggt att cca ctg acg gcg gat atc gac atg ttc        576
Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe           
            180                 185                 190                   

gcc att atg ccg cat ctg tcc aac ttc cgc gac tcg gcg cgc agt tcg        624
Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser           
        195                 200                 205                       

gtg acc agc ggc gat tcg gtg acc gat tac ctg gcg cgc acg cgg cgg        672
Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg           
    210                 215                 220                           

gcc gcc agc gag gcc acg ggc ggc ctg gat cgc gaa cgc atc gac ttg        720
Ala Ala Ser Glu Ala Thr Gly Gly Leu Asp Arg Glu Arg Ile Asp Leu           
225                 230                 235                 240           

ttg tgg aaa atc gct cgc gcc ggc gcc cgt tcc gca gtg ggc acc gag        768
Leu Trp Lys Ile Ala Arg Ala Gly Ala Arg Ser Ala Val Gly Thr Glu           
                245                 250                 255               

gcg cgt cgc cag ttc cgc tac gac ggc gac atg aat atc ggc gtg atc        816
Ala Arg Arg Gln Phe Arg Tyr Asp Gly Asp Met Asn Ile Gly Val Ile           
            260                 265                 270                   

acc gat ttc gag ctg gaa gtg cgc aat gcg ctg aac agg cgg gcg cac        864
Thr Asp Phe Glu Leu Glu Val Arg Asn Ala Leu Asn Arg Arg Ala His           
        275                 280                 285                       

gcc gtc ggc gcg cag gac gtg gtc cag cat ggc act gag cag aac aat        912
Ala Val Gly Ala Gln Asp Val Val Gln His Gly Thr Glu Gln Asn Asn           
    290                 295                 300                           

cct ttc ccg gag gca gat gag aag att ttc gtc gta tcg gcc acc ggt        960
Pro Phe Pro Glu Ala Asp Glu Lys Ile Phe Val Val Ser Ala Thr Gly           
305                 310                 315                 320           

gaa agc cag atg ctc acg cgc ggg caa ctg aag gaa tac att ggc cag       1008
Glu Ser Gln Met Leu Thr Arg Gly Gln Leu Lys Glu Tyr Ile Gly Gln           
                325                 330                 335               

cag cgc ggc gag ggc tat gtc ttc tac gag aac cgt gca tac ggc gtg       1056
Gln Arg Gly Glu Gly Tyr Val Phe Tyr Glu Asn Arg Ala Tyr Gly Val           
            340                 345                 350                   

gcg ggg aaa agc ctg ttc gac gat ggg ctg gga gcc gcg ccc ggc gtg       1104
Ala Gly Lys Ser Leu Phe Asp Asp Gly Leu Gly Ala Ala Pro Gly Val           
        355                 360                 365                       

ccg agc gga cgt tcg aag ttc tcg ccg gat gta ctg gaa acg gtg ccg       1152
Pro Ser Gly Arg Ser Lys Phe Ser Pro Asp Val Leu Glu Thr Val Pro           
    370                 375                 380                           

gcg tca ccc gga ttg cgg cgg ccg tcg ctg ggc gca gtg gaa cgc cag       1200
Ala Ser Pro Gly Leu Arg Arg Pro Ser Leu Gly Ala Val Glu Arg Gln           
385                 390                 395                 400           

gat tcc ggc tat gac agc ctt gat ggg gtg gga tcg cga tcg ttc tcg       1248
Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly Ser Arg Ser Phe Ser           
                405                 410                 415               

ttg ggc gag gtg tcc gac atg gcc gcc gtg gaa gcg gcg gaa ctg gaa       1296
Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu Ala Ala Glu Leu Glu           
            420                 425                 430                   

atg acc cgg caa gtc ttg cac gcc ggg gcg cgg cag gac gat gcc gag       1344
Met Thr Arg Gln Val Leu His Ala Gly Ala Arg Gln Asp Asp Ala Glu           
        435                 440                 445                       

ccg ggc gtg agc ggt gcg tcg gcg cac tgg ggg cag cgg gcg ctg cag       1392
Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly Gln Arg Ala Leu Gln           
    450                 455                 460                           

ggc gcc cag gcg gtg gcg gcg gcg cag cgg ctg gtt cat gcc att gcc       1440
Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu Val His Ala Ile Ala           
465                 470                 475                 480           

ctg atg acg caa ttc ggc cgg gcc ggt tcc acc aac acg ccg cag gaa       1488
Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr Asn Thr Pro Gln Glu           
                485                 490                 495               

gcg gcc tcg ttg tcg gcg gcc gtg ttc ggc ttg ggc gag gcc agc agc       1536
Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu Gly Glu Ala Ser Ser           
            500                 505                 510                   

gcc gtg gcc gaa acc gtg agc ggt ttt ttc cgc ggg tct tcg cgc tgg       1584
Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg Gly Ser Ser Arg Trp           
        515                 520                 525                       

gcc ggc ggt ttc ggc gtg gct ggc ggc gcg atg gcg ctg gga ggc ggc       1632
Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met Ala Leu Gly Gly Gly           
    530                 535                 540                           

atc gcc gcg gcc gtt ggc gcc ggg atg tcg ttg acc gat gac gcg ccg       1680
Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu Thr Asp Asp Ala Pro           
545                 550                 555                 560           

gcc gga cag aag gcc gcc gcc ggc gcc gag atc gcg ctg cag ttg aca       1728
Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile Ala Leu Gln Leu Thr           
                565                 570                 575               

ggt gga acg gtc gag ctg gct tct tcc atc gcg ttg gcg ctg gcc gcg       1776
Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu Ala Leu Ala Ala           
            580                 585                 590                   

gcg cgc ggc gtg acc agc ggc ttg cag gtg gcc ggg gcg tcg gcc ggg       1824
Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly Ala Ser Ala Gly           
        595                 600                 605                       

gcg gct gcc ggc gca ttg gcc gcg gcg ctc agt ccc atg gag atc tac       1872
Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro Met Glu Ile Tyr           
    610                 615                 620                           

ggc ctg gtg cag caa tcg cac tat gcg gat cag ctg gac aag ctg gcg       1920
Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu Asp Lys Leu Ala           
625                 630                 635                 640           

cag gaa tcg agc gca tac ggt tac gag ggc gac gcc ttg ctg gcc cag       1968
Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala Leu Leu Ala Gln           
                645                 650                 655               

ctg tat cgc gac aag acg gcc gcc gag ggc gcc gtc gcc ggc gtc tcc       2016
Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val Ala Gly Val Ser           
            660                 665                 670                   

gcc gtc ctg agc acg gtg ggg gcg gcg gtg tcg atc gcc gcg gcg gcc       2064
Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile Ala Ala Ala Ala           
        675                 680                 685                       

agc gtg gta ggg gcc ccg gtg gcg gtg gtc act tcc ttg ctg acc ggg       2112
Ser Val Val Gly Ala Pro Val Ala Val Val Thr Ser Leu Leu Thr Gly           
    690                 695                 700                           

gct ctc aac ggc atc ctg cgc ggc gtg cag cag ccc atc atc gaa aag       2160
Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro Ile Ile Glu Lys           
705                 710                 715                 720           

ctg gcc aac gat tac gct cgc aag atc gac gag ctg ggc ggg ccg caa       2208
Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu Gly Gly Pro Gln           
                725                 730                 735               

gcg tac ttc gag aaa aac ctg cag gcg cgt cac gaa caa ctg gcc aat       2256
Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu Gln Leu Ala Asn           
            740                 745                 750                   

tcg gac ggc cta cgg aaa atg ctg gcc gac ctg cag gcc ggt tgg aac       2304
Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln Ala Gly Trp Asn           
        755                 760                 765                       

gcc agc agc gtg atc ggg gtg cag acg aca gag atc tcc aag tcg gcg       2352
Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile Ser Lys Ser Ala           
    770                 775                 780                           

ctc gaa ctg gcc gcc att acc ggc aac gcg gac aac ctg aaa tcc gtc       2400
Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn Leu Lys Ser Val           
785                 790                 795                 800           

gac gtg ttc gtg gac cgc ttc gtc cag ggc gag cgg gtg gcc ggc cag       2448
Asp Val Phe Val Asp Arg Phe Val Gln Gly Glu Arg Val Ala Gly Gln           
                805                 810                 815               

ccg gtg gtc ctc gac gtc gcc gcc ggc ggc atc gat atc gcc agc cgc       2496
Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp Ile Ala Ser Arg           
            820                 825                 830                   

aag ggc gag cgg ccg gcg ctg acg ttc atc acg ccg ctg gcc gcg cca       2544
Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro Leu Ala Ala Pro           
        835                 840                 845                       

gga gaa gag cag cgc cgg cgc acg aaa acg ggc aag agc gaa ttc acc       2592
Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys Ser Glu Phe Thr           
    850                 855                 860                           

aca ttc gtc gag atc gtg ggc aag cag gac cgc tgg cgc atc cgg gac       2640
Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp Arg Ile Arg Asp           
865                 870                 875                 880           

ggc gcg gcc gac acc acc atc gat ctg gcc aag gtg gtg tcg caa ctg       2688
Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val Val Ser Gln Leu           
                885                 890                 895               

gtc gac gcc aat ggc gtg ctc aag cac agc atc aaa ctg gat gtg atc       2736
Val Asp Ala Asn Gly Val Leu Lys His Ser Ile Lys Leu Asp Val Ile           
            900                 905                 910                   

ggc gga gat ggc gat gac gtc gtg ctt gcc aat gct tcg cgc atc cat       2784
Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn Ala Ser Arg Ile His           
        915                 920                 925                       

tat gac ggc ggc gcg ggc acc aac acg gtc agc tat gcc gcc ctg ggt       2832
Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser Tyr Ala Ala Leu Gly           
    930                 935                 940                           

cga cag gat tcc att acc gtg tcc gcc gac ggg gaa cgt ttc aac gtg       2880
Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly Glu Arg Phe Asn Val           
945                 950                 955                 960           

cgc aag cag ttg aac aac gcc aac gtg tat cgc gaa ggc gtg gct acc       2928
Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg Glu Gly Val Ala Thr           
                965                 970                 975               

cag aca acc gcc tac ggc aag cgc acg gag aat gtc caa tac cgc cat       2976
Gln Thr Thr Ala Tyr Gly Lys Arg Thr Glu Asn Val Gln Tyr Arg His           
            980                 985                 990                   

gtc gag ctg gcc cgt gtc ggg caa  ctg gtg gag gtc gac  acg ctc gag     3024
Val Glu Leu Ala Arg Val Gly Gln  Leu Val Glu Val Asp  Thr Leu Glu         
        995                 1000                 1005                     

cat gtg  cag cac atc atc ggc  ggg gcc ggc aac gat  tcg atc acc        3069
His Val  Gln His Ile Ile Gly  Gly Ala Gly Asn Asp  Ser Ile Thr            
    1010                 1015                 1020                        

ggc aat  gcg cac gac aac ttc  cta gcc ggc ggg tcg  ggc gac gac        3114
Gly Asn  Ala His Asp Asn Phe  Leu Ala Gly Gly Ser  Gly Asp Asp            
    1025                 1030                 1035                        

agg ctg  gat ggc ggc gcc ggc  aac gac acc ctg gtt  ggc ggc gag        3159
Arg Leu  Asp Gly Gly Ala Gly  Asn Asp Thr Leu Val  Gly Gly Glu            
    1040                 1045                 1050                        

ggc caa  aac acg gtc atc ggc  ggc gcc ggc gac gac  gta ttc ctg        3204
Gly Gln  Asn Thr Val Ile Gly  Gly Ala Gly Asp Asp  Val Phe Leu            
    1055                 1060                 1065                        

cag gac  ctg ggg gta tgg agc  aac cag ctc gat ggc  ggc gcg ggc        3249
Gln Asp  Leu Gly Val Trp Ser  Asn Gln Leu Asp Gly  Gly Ala Gly            
    1070                 1075                 1080                        

gtc gat  acc gtg aag tac aac  gtg cac cag cct tcc  gag gag cgc        3294
Val Asp  Thr Val Lys Tyr Asn  Val His Gln Pro Ser  Glu Glu Arg            
    1085                 1090                 1095                        

ctc gaa  cgc atg ggc gac acg  ggc atc cat gcc gat  ctt caa aag        3339
Leu Glu  Arg Met Gly Asp Thr  Gly Ile His Ala Asp  Leu Gln Lys            
    1100                 1105                 1110                        

ggc acg  gtc gag aag tgg ccg  gcc ctg aac ctg ttc  agc gtc gac        3384
Gly Thr  Val Glu Lys Trp Pro  Ala Leu Asn Leu Phe  Ser Val Asp            
    1115                 1120                 1125                        

cat gtc  aag aat atc gag aat  ctg cac ggc tcc cgc  ctg aac gac        3429
His Val  Lys Asn Ile Glu Asn  Leu His Gly Ser Arg  Leu Asn Asp            
    1130                 1135                 1140                        

cgc atc  gcc ggc gac gac cag  gac aac gag ctc tgg  ggc cac gat        3474
Arg Ile  Ala Gly Asp Asp Gln  Asp Asn Glu Leu Trp  Gly His Asp            
    1145                 1150                 1155                        

ggc aac  gac acg ata cgc ggc  cgg ggc ggc gac gac  atc ctg cgc        3519
Gly Asn  Asp Thr Ile Arg Gly  Arg Gly Gly Asp Asp  Ile Leu Arg            
    1160                 1165                 1170                        

ggc ggc  ctg ggc ctg gac acg  ctg tat ggc gag gac  ggc aac gac        3564
Gly Gly  Leu Gly Leu Asp Thr  Leu Tyr Gly Glu Asp  Gly Asn Asp            
    1175                 1180                 1185                        

atc ttc  ctg cag gac gac gag  acc gtc agc gat gac  atc gac ggc        3609
Ile Phe  Leu Gln Asp Asp Glu  Thr Val Ser Asp Asp  Ile Asp Gly            
    1190                 1195                 1200                        

ggc gcg  ggg ctg gac acc gtc  gac tac tcc gcc atg  atc cat cca        3654
Gly Ala  Gly Leu Asp Thr Val  Asp Tyr Ser Ala Met  Ile His Pro            
    1205                 1210                 1215                        

ggc agg  atc gtt gcg ccg cat  gaa tac ggc ttc ggg  atc gag gcg        3699
Gly Arg  Ile Val Ala Pro His  Glu Tyr Gly Phe Gly  Ile Glu Ala            
    1220                 1225                 1230                        

gac ctg  tcc agg gaa tgg gtg  cgc aag gcg tcc gcg  ctg ggc gtg        3744
Asp Leu  Ser Arg Glu Trp Val  Arg Lys Ala Ser Ala  Leu Gly Val            
    1235                 1240                 1245                        

gac tat  tac gat aat gtc cgc  aat gtc gaa aac gtc  atc ggt acg        3789
Asp Tyr  Tyr Asp Asn Val Arg  Asn Val Glu Asn Val  Ile Gly Thr            
    1250                 1255                 1260                        

agc atg  aag gat gtg ctc atc  ggc gac gcg caa gcc  aat acc ctg        3834
Ser Met  Lys Asp Val Leu Ile  Gly Asp Ala Gln Ala  Asn Thr Leu            
    1265                 1270                 1275                        

atg ggc  cag ggc ggc gac gat  acc gtg cgc ggc ggc  gac ggc gat        3879
Met Gly  Gln Gly Gly Asp Asp  Thr Val Arg Gly Gly  Asp Gly Asp            
    1280                 1285                 1290                        

gat ctg  ctg ttc ggc ggc gac  ggc aac gac atg ctg  tat ggc gac        3924
Asp Leu  Leu Phe Gly Gly Asp  Gly Asn Asp Met Leu  Tyr Gly Asp            
    1295                 1300                 1305                        

gcc ggc  aac gac acc ctc tac  ggg ggg ctg ggc gac  gat acc ctt        3969
Ala Gly  Asn Asp Thr Leu Tyr  Gly Gly Leu Gly Asp  Asp Thr Leu            
    1310                 1315                 1320                        

gaa ggc  ggc gcg ggc aac gat  tgg ttc ggc cag acg  cag gcg cgc        4014
Glu Gly  Gly Ala Gly Asn Asp  Trp Phe Gly Gln Thr  Gln Ala Arg            
    1325                 1330                 1335                        

gag cat  gac gtg ctg cgc ggc  gga gat ggg gtg gat  acc gtc gat        4059
Glu His  Asp Val Leu Arg Gly  Gly Asp Gly Val Asp  Thr Val Asp            
    1340                 1345                 1350                        

tac agc  cag acc ggc gcg cat  gcc ggc att gcc gcg  ggt cgc atc        4104
Tyr Ser  Gln Thr Gly Ala His  Ala Gly Ile Ala Ala  Gly Arg Ile            
    1355                 1360                 1365                        

ggg ctg  ggc atc ctg gct gac  ctg ggc gcc ggc cgc  gtc gac aag        4149
Gly Leu  Gly Ile Leu Ala Asp  Leu Gly Ala Gly Arg  Val Asp Lys            
    1370                 1375                 1380                        

ctg ggc  gag gcc ggc agc agc  gcc tac gat acg gtt  tcc ggt atc        4194
Leu Gly  Glu Ala Gly Ser Ser  Ala Tyr Asp Thr Val  Ser Gly Ile            
    1385                 1390                 1395                        

gag aac  gtg gtg ggc acg gaa  ctg gcc gac cgc atc  acg ggc gat        4239
Glu Asn  Val Val Gly Thr Glu  Leu Ala Asp Arg Ile  Thr Gly Asp            
    1400                 1405                 1410                        

gcg cag  gcc aac gtg ctg cgc  ggc gcg ggt ggc gcc  gac gtg ctt        4284
Ala Gln  Ala Asn Val Leu Arg  Gly Ala Gly Gly Ala  Asp Val Leu            
    1415                 1420                 1425                        

gcg ggc  ggc gag ggc gac gat  gtg ctg ctg ggc ggc  gac ggc gac        4329
Ala Gly  Gly Glu Gly Asp Asp  Val Leu Leu Gly Gly  Asp Gly Asp            
    1430                 1435                 1440                        

gac cag  ctg tcg ggc gac gcc  gga cgc gat cgc ttg  tac ggc gaa        4374
Asp Gln  Leu Ser Gly Asp Ala  Gly Arg Asp Arg Leu  Tyr Gly Glu            
    1445                 1450                 1455                        

gcc ggt  gac gac tgg ttc ttc  cag gat gcc gcc aat  gcc ggc aat        4419
Ala Gly  Asp Asp Trp Phe Phe  Gln Asp Ala Ala Asn  Ala Gly Asn            
    1460                 1465                 1470                        

ctg ctc  gac ggc ggc gac ggc  cgc gat acc gtg gat  ttc agc ggc        4464
Leu Leu  Asp Gly Gly Asp Gly  Arg Asp Thr Val Asp  Phe Ser Gly            
    1475                 1480                 1485                        

ccg ggc  cgg ggc ctc gac gcc  ggc gca aag ggc gta  ttc ctg agc        4509
Pro Gly  Arg Gly Leu Asp Ala  Gly Ala Lys Gly Val  Phe Leu Ser            
    1490                 1495                 1500                        

ttg ggc  aag ggg ttc gcc agc  ctg atg gac gaa ccc  gaa acc agc        4554
Leu Gly  Lys Gly Phe Ala Ser  Leu Met Asp Glu Pro  Glu Thr Ser            
    1505                 1510                 1515                        

aac gtg  ttg cgc aat atc gag  aac gcc gtg ggc agc  gcg cgt gat        4599
Asn Val  Leu Arg Asn Ile Glu  Asn Ala Val Gly Ser  Ala Arg Asp            
    1520                 1525                 1530                        

gac gtg  ctg atc ggc gac gca  ggc gcc aac gtc ctc  aat ggc ctg        4644
Asp Val  Leu Ile Gly Asp Ala  Gly Ala Asn Val Leu  Asn Gly Leu            
    1535                 1540                 1545                        

gcg ggc  aac gac gtg ctg tcc  ggc ggc gct ggc gac  gat gtg ctg        4689
Ala Gly  Asn Asp Val Leu Ser  Gly Gly Ala Gly Asp  Asp Val Leu            
    1550                 1555                 1560                        

ctg ggc  gac gag ggc tcg gac  ctg ctc agc ggc gat  gcg ggc aac        4734
Leu Gly  Asp Glu Gly Ser Asp  Leu Leu Ser Gly Asp  Ala Gly Asn            
    1565                 1570                 1575                        

gac gat  ctg ttc ggc ggg cag  ggc gat gat act tat  ctg ttc ggg        4779
Asp Asp  Leu Phe Gly Gly Gln  Gly Asp Asp Thr Tyr  Leu Phe Gly            
    1580                 1585                 1590                        

gtc ggg  tac ggg cac gac acg  atc tac gaa tcg ggc  ggc ggc cat        4824
Val Gly  Tyr Gly His Asp Thr  Ile Tyr Glu Ser Gly  Gly Gly His            
    1595                 1600                 1605                        

gac acc  atc cgc atc aac gcg  ggg gcg gac cag ctg  tgg ttc gcg        4869
Asp Thr  Ile Arg Ile Asn Ala  Gly Ala Asp Gln Leu  Trp Phe Ala            
    1610                 1615                 1620                        

cgc cag  ggc aac gac ctg gag  atc cgc att ctc ggc  acc gac gat        4914
Arg Gln  Gly Asn Asp Leu Glu  Ile Arg Ile Leu Gly  Thr Asp Asp            
    1625                 1630                 1635                        

gca ctt  acc gtg cac gac tgg  tat cgc gac gcc gat  cac cgg gtg        4959
Ala Leu  Thr Val His Asp Trp  Tyr Arg Asp Ala Asp  His Arg Val            
    1640                 1645                 1650                        

gaa atc  atc cat gcc gcc aac  cag gcg gta gac cag  gca ggc atc        5004
Glu Ile  Ile His Ala Ala Asn  Gln Ala Val Asp Gln  Ala Gly Ile            
    1655                 1660                 1665                        

gaa aag  ctg gtc gag gca atg  gcg cag tat ccg gac  ccc ggc gcg        5049
Glu Lys  Leu Val Glu Ala Met  Ala Gln Tyr Pro Asp  Pro Gly Ala            
    1670                 1675                 1680                        

gcg gcg  gct gcc ccg ccg gcg  gcg cgc gtg ccg gac  acg ctg atg        5094
Ala Ala  Ala Ala Pro Pro Ala  Ala Arg Val Pro Asp  Thr Leu Met            
    1685                 1690                 1695                        

cag tcc  ctg gct gtc aac tgg  cgc tga                                 5121
Gln Ser  Leu Ala Val Asn Trp  Arg                                         
    1700                 1705                                             


<210>  4
<211>  1706
<212>  PRT
<213>  Bordetella hinzii (wild type CyaA)

<400>  4

Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu 
1               5                   10                  15      


Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys 
            20                  25                  30          


Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr 
        35                  40                  45              


Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala 
    50                  55                  60                  


Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro 
65                  70                  75                  80  


Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala 
                85                  90                  95      


Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp 
            100                 105                 110         


Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu 
        115                 120                 125             


Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr 
    130                 135                 140                 


Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala 
145                 150                 155                 160 


Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val 
                165                 170                 175     


Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe 
            180                 185                 190         


Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser 
        195                 200                 205             


Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg 
    210                 215                 220                 


Ala Ala Ser Glu Ala Thr Gly Gly Leu Asp Arg Glu Arg Ile Asp Leu 
225                 230                 235                 240 


Leu Trp Lys Ile Ala Arg Ala Gly Ala Arg Ser Ala Val Gly Thr Glu 
                245                 250                 255     


Ala Arg Arg Gln Phe Arg Tyr Asp Gly Asp Met Asn Ile Gly Val Ile 
            260                 265                 270         


Thr Asp Phe Glu Leu Glu Val Arg Asn Ala Leu Asn Arg Arg Ala His 
        275                 280                 285             


Ala Val Gly Ala Gln Asp Val Val Gln His Gly Thr Glu Gln Asn Asn 
    290                 295                 300                 


Pro Phe Pro Glu Ala Asp Glu Lys Ile Phe Val Val Ser Ala Thr Gly 
305                 310                 315                 320 


Glu Ser Gln Met Leu Thr Arg Gly Gln Leu Lys Glu Tyr Ile Gly Gln 
                325                 330                 335     


Gln Arg Gly Glu Gly Tyr Val Phe Tyr Glu Asn Arg Ala Tyr Gly Val 
            340                 345                 350         


Ala Gly Lys Ser Leu Phe Asp Asp Gly Leu Gly Ala Ala Pro Gly Val 
        355                 360                 365             


Pro Ser Gly Arg Ser Lys Phe Ser Pro Asp Val Leu Glu Thr Val Pro 
    370                 375                 380                 


Ala Ser Pro Gly Leu Arg Arg Pro Ser Leu Gly Ala Val Glu Arg Gln 
385                 390                 395                 400 


Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly Ser Arg Ser Phe Ser 
                405                 410                 415     


Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu Ala Ala Glu Leu Glu 
            420                 425                 430         


Met Thr Arg Gln Val Leu His Ala Gly Ala Arg Gln Asp Asp Ala Glu 
        435                 440                 445             


Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly Gln Arg Ala Leu Gln 
    450                 455                 460                 


Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu Val His Ala Ile Ala 
465                 470                 475                 480 


Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr Asn Thr Pro Gln Glu 
                485                 490                 495     


Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu Gly Glu Ala Ser Ser 
            500                 505                 510         


Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg Gly Ser Ser Arg Trp 
        515                 520                 525             


Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met Ala Leu Gly Gly Gly 
    530                 535                 540                 


Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu Thr Asp Asp Ala Pro 
545                 550                 555                 560 


Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile Ala Leu Gln Leu Thr 
                565                 570                 575     


Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu Ala Leu Ala Ala 
            580                 585                 590         


Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly Ala Ser Ala Gly 
        595                 600                 605             


Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro Met Glu Ile Tyr 
    610                 615                 620                 


Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu Asp Lys Leu Ala 
625                 630                 635                 640 


Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala Leu Leu Ala Gln 
                645                 650                 655     


Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val Ala Gly Val Ser 
            660                 665                 670         


Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile Ala Ala Ala Ala 
        675                 680                 685             


Ser Val Val Gly Ala Pro Val Ala Val Val Thr Ser Leu Leu Thr Gly 
    690                 695                 700                 


Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro Ile Ile Glu Lys 
705                 710                 715                 720 


Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu Gly Gly Pro Gln 
                725                 730                 735     


Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu Gln Leu Ala Asn 
            740                 745                 750         


Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln Ala Gly Trp Asn 
        755                 760                 765             


Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile Ser Lys Ser Ala 
    770                 775                 780                 


Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn Leu Lys Ser Val 
785                 790                 795                 800 


Asp Val Phe Val Asp Arg Phe Val Gln Gly Glu Arg Val Ala Gly Gln 
                805                 810                 815     


Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp Ile Ala Ser Arg 
            820                 825                 830         


Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro Leu Ala Ala Pro 
        835                 840                 845             


Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys Ser Glu Phe Thr 
    850                 855                 860                 


Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp Arg Ile Arg Asp 
865                 870                 875                 880 


Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val Val Ser Gln Leu 
                885                 890                 895     


Val Asp Ala Asn Gly Val Leu Lys His Ser Ile Lys Leu Asp Val Ile 
            900                 905                 910         


Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn Ala Ser Arg Ile His 
        915                 920                 925             


Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser Tyr Ala Ala Leu Gly 
    930                 935                 940                 


Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly Glu Arg Phe Asn Val 
945                 950                 955                 960 


Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg Glu Gly Val Ala Thr 
                965                 970                 975     


Gln Thr Thr Ala Tyr Gly Lys Arg Thr Glu Asn Val Gln Tyr Arg His 
            980                 985                 990         


Val Glu Leu Ala Arg Val Gly Gln  Leu Val Glu Val Asp  Thr Leu Glu 
        995                 1000                 1005             


His Val  Gln His Ile Ile Gly  Gly Ala Gly Asn Asp  Ser Ile Thr 
    1010                 1015                 1020             


Gly Asn  Ala His Asp Asn Phe  Leu Ala Gly Gly Ser  Gly Asp Asp 
    1025                 1030                 1035             


Arg Leu  Asp Gly Gly Ala Gly  Asn Asp Thr Leu Val  Gly Gly Glu 
    1040                 1045                 1050             


Gly Gln  Asn Thr Val Ile Gly  Gly Ala Gly Asp Asp  Val Phe Leu 
    1055                 1060                 1065             


Gln Asp  Leu Gly Val Trp Ser  Asn Gln Leu Asp Gly  Gly Ala Gly 
    1070                 1075                 1080             


Val Asp  Thr Val Lys Tyr Asn  Val His Gln Pro Ser  Glu Glu Arg 
    1085                 1090                 1095             


Leu Glu  Arg Met Gly Asp Thr  Gly Ile His Ala Asp  Leu Gln Lys 
    1100                 1105                 1110             


Gly Thr  Val Glu Lys Trp Pro  Ala Leu Asn Leu Phe  Ser Val Asp 
    1115                 1120                 1125             


His Val  Lys Asn Ile Glu Asn  Leu His Gly Ser Arg  Leu Asn Asp 
    1130                 1135                 1140             


Arg Ile  Ala Gly Asp Asp Gln  Asp Asn Glu Leu Trp  Gly His Asp 
    1145                 1150                 1155             


Gly Asn  Asp Thr Ile Arg Gly  Arg Gly Gly Asp Asp  Ile Leu Arg 
    1160                 1165                 1170             


Gly Gly  Leu Gly Leu Asp Thr  Leu Tyr Gly Glu Asp  Gly Asn Asp 
    1175                 1180                 1185             


Ile Phe  Leu Gln Asp Asp Glu  Thr Val Ser Asp Asp  Ile Asp Gly 
    1190                 1195                 1200             


Gly Ala  Gly Leu Asp Thr Val  Asp Tyr Ser Ala Met  Ile His Pro 
    1205                 1210                 1215             


Gly Arg  Ile Val Ala Pro His  Glu Tyr Gly Phe Gly  Ile Glu Ala 
    1220                 1225                 1230             


Asp Leu  Ser Arg Glu Trp Val  Arg Lys Ala Ser Ala  Leu Gly Val 
    1235                 1240                 1245             


Asp Tyr  Tyr Asp Asn Val Arg  Asn Val Glu Asn Val  Ile Gly Thr 
    1250                 1255                 1260             


Ser Met  Lys Asp Val Leu Ile  Gly Asp Ala Gln Ala  Asn Thr Leu 
    1265                 1270                 1275             


Met Gly  Gln Gly Gly Asp Asp  Thr Val Arg Gly Gly  Asp Gly Asp 
    1280                 1285                 1290             


Asp Leu  Leu Phe Gly Gly Asp  Gly Asn Asp Met Leu  Tyr Gly Asp 
    1295                 1300                 1305             


Ala Gly  Asn Asp Thr Leu Tyr  Gly Gly Leu Gly Asp  Asp Thr Leu 
    1310                 1315                 1320             


Glu Gly  Gly Ala Gly Asn Asp  Trp Phe Gly Gln Thr  Gln Ala Arg 
    1325                 1330                 1335             


Glu His  Asp Val Leu Arg Gly  Gly Asp Gly Val Asp  Thr Val Asp 
    1340                 1345                 1350             


Tyr Ser  Gln Thr Gly Ala His  Ala Gly Ile Ala Ala  Gly Arg Ile 
    1355                 1360                 1365             


Gly Leu  Gly Ile Leu Ala Asp  Leu Gly Ala Gly Arg  Val Asp Lys 
    1370                 1375                 1380             


Leu Gly  Glu Ala Gly Ser Ser  Ala Tyr Asp Thr Val  Ser Gly Ile 
    1385                 1390                 1395             


Glu Asn  Val Val Gly Thr Glu  Leu Ala Asp Arg Ile  Thr Gly Asp 
    1400                 1405                 1410             


Ala Gln  Ala Asn Val Leu Arg  Gly Ala Gly Gly Ala  Asp Val Leu 
    1415                 1420                 1425             


Ala Gly  Gly Glu Gly Asp Asp  Val Leu Leu Gly Gly  Asp Gly Asp 
    1430                 1435                 1440             


Asp Gln  Leu Ser Gly Asp Ala  Gly Arg Asp Arg Leu  Tyr Gly Glu 
    1445                 1450                 1455             


Ala Gly  Asp Asp Trp Phe Phe  Gln Asp Ala Ala Asn  Ala Gly Asn 
    1460                 1465                 1470             


Leu Leu  Asp Gly Gly Asp Gly  Arg Asp Thr Val Asp  Phe Ser Gly 
    1475                 1480                 1485             


Pro Gly  Arg Gly Leu Asp Ala  Gly Ala Lys Gly Val  Phe Leu Ser 
    1490                 1495                 1500             


Leu Gly  Lys Gly Phe Ala Ser  Leu Met Asp Glu Pro  Glu Thr Ser 
    1505                 1510                 1515             


Asn Val  Leu Arg Asn Ile Glu  Asn Ala Val Gly Ser  Ala Arg Asp 
    1520                 1525                 1530             


Asp Val  Leu Ile Gly Asp Ala  Gly Ala Asn Val Leu  Asn Gly Leu 
    1535                 1540                 1545             


Ala Gly  Asn Asp Val Leu Ser  Gly Gly Ala Gly Asp  Asp Val Leu 
    1550                 1555                 1560             


Leu Gly  Asp Glu Gly Ser Asp  Leu Leu Ser Gly Asp  Ala Gly Asn 
    1565                 1570                 1575             


Asp Asp  Leu Phe Gly Gly Gln  Gly Asp Asp Thr Tyr  Leu Phe Gly 
    1580                 1585                 1590             


Val Gly  Tyr Gly His Asp Thr  Ile Tyr Glu Ser Gly  Gly Gly His 
    1595                 1600                 1605             


Asp Thr  Ile Arg Ile Asn Ala  Gly Ala Asp Gln Leu  Trp Phe Ala 
    1610                 1615                 1620             


Arg Gln  Gly Asn Asp Leu Glu  Ile Arg Ile Leu Gly  Thr Asp Asp 
    1625                 1630                 1635             


Ala Leu  Thr Val His Asp Trp  Tyr Arg Asp Ala Asp  His Arg Val 
    1640                 1645                 1650             


Glu Ile  Ile His Ala Ala Asn  Gln Ala Val Asp Gln  Ala Gly Ile 
    1655                 1660                 1665             


Glu Lys  Leu Val Glu Ala Met  Ala Gln Tyr Pro Asp  Pro Gly Ala 
    1670                 1675                 1680             


Ala Ala  Ala Ala Pro Pro Ala  Ala Arg Val Pro Asp  Thr Leu Met 
    1685                 1690                 1695             


Gln Ser  Leu Ala Val Asn Trp  Arg 
    1700                 1705     


<210>  5
<211>  5121
<212>  DNA
<213>  Bordetella parapertussis (wild type CyaA)


<220>
<221>  CDS
<222>  (1)..(5121)

<400>  5
atg cag caa tcg cat cag gct ggt tac gca aac gcc gcc gac cgg gag         48
Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu           
1               5                   10                  15                

tct ggc atc ccc gca gcc gta ctc gat ggc atc aag gcc gtg gcg aag         96
Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys           
            20                  25                  30                    

gaa aaa aac gcc aca ttg atg ttc cgc ctg gtc aac ccc cat tcc acc        144
Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr           
        35                  40                  45                        

agc ctg att gcc gaa ggg gtg gcc acc aaa gga ttg ggc gtg cac gcc        192
Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala           
    50                  55                  60                            

aag tcg tcc gat tgg ggg ttg cag gcg ggc tac att ccc gtc aac ccg        240
Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro           
65                  70                  75                  80            

aat ctt tcc aaa ctg ttc ggc cgt gcg ccc gag gtg atc gcg cgg gcc        288
Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala           
                85                  90                  95                

gac aac gac gtc aac agc agc ctg gcg cat ggc cat acc gcg gtc gac        336
Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp           
            100                 105                 110                   

ctg acg ctg tcg aaa gag cgg ctt gac tat ctg cgg caa gcg ggc ctg        384
Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu           
        115                 120                 125                       

gtc acc ggc atg gcc gat ggc gtg gtc gcg agc aac cac gca ggc tac        432
Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr           
    130                 135                 140                           

gag cag ttc gag ttt cgc gtg aag gaa acc tcg gac ggg cgc tat gcc        480
Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala           
145                 150                 155                 160           

gtg cag tat cgc cgc aag ggc ggc gac gat ttc gag gcg gtc aag gtg        528
Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val           
                165                 170                 175               

atc ggc aat gcc gcc ggt att cca ctg acg gcg gat atc gac atg ttc        576
Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe           
            180                 185                 190                   

gcc atc atg ccg cat ctg tcc aac ttc cgc gac tcg gcg cgc agt tcg        624
Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser           
        195                 200                 205                       

gtg acc agc ggc gat tcg gtg acc gat tac ctg gcg cgc acg cgg cgg        672
Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg           
    210                 215                 220                           

gcc gcc agc gag gcc acg ggc ggc ctg gat cgc gaa cgc atc gac ttg        720
Ala Ala Ser Glu Ala Thr Gly Gly Leu Asp Arg Glu Arg Ile Asp Leu           
225                 230                 235                 240           

ttg tgg aaa atc gct cgc gcc ggc gcc cgt tcc gca gtg ggc acc gag        768
Leu Trp Lys Ile Ala Arg Ala Gly Ala Arg Ser Ala Val Gly Thr Glu           
                245                 250                 255               

gcg cgt cgc cag ttc cgc tac gac ggc gac atg aat atc ggc gtg atc        816
Ala Arg Arg Gln Phe Arg Tyr Asp Gly Asp Met Asn Ile Gly Val Ile           
            260                 265                 270                   

acc gat ttc gag ctg gaa gtg cgc aat gcg ctg aac agg cgg gcg cac        864
Thr Asp Phe Glu Leu Glu Val Arg Asn Ala Leu Asn Arg Arg Ala His           
        275                 280                 285                       

gcc gtc ggc gcg cag gac gtg gtc cag cat ggc act gag cag aac aat        912
Ala Val Gly Ala Gln Asp Val Val Gln His Gly Thr Glu Gln Asn Asn           
    290                 295                 300                           

cct ttc ccg gag gca gat gag aag att ttc gtc gta tcg gcc acc ggt        960
Pro Phe Pro Glu Ala Asp Glu Lys Ile Phe Val Val Ser Ala Thr Gly           
305                 310                 315                 320           

gaa agc cag atg ctc acg cgc ggg caa ctg aag gaa tac att ggc cag       1008
Glu Ser Gln Met Leu Thr Arg Gly Gln Leu Lys Glu Tyr Ile Gly Gln           
                325                 330                 335               

cag cgc ggc gag ggc tat gtc ttc tac gag aac cgt gca tac ggc gtg       1056
Gln Arg Gly Glu Gly Tyr Val Phe Tyr Glu Asn Arg Ala Tyr Gly Val           
            340                 345                 350                   

gcg ggg aaa agc ctg ttc gac gat ggg ctg gga gcc gcg ccc ggc gtg       1104
Ala Gly Lys Ser Leu Phe Asp Asp Gly Leu Gly Ala Ala Pro Gly Val           
        355                 360                 365                       

ccg ggc gga cgt tcg aag tcc tcg ccg gat gta ctg gaa acg gtg ccg       1152
Pro Gly Gly Arg Ser Lys Ser Ser Pro Asp Val Leu Glu Thr Val Pro           
    370                 375                 380                           

gcg tca ccc gga ttg cgg cgg ccg tcg ctg ggc gca gtg gaa cgc cag       1200
Ala Ser Pro Gly Leu Arg Arg Pro Ser Leu Gly Ala Val Glu Arg Gln           
385                 390                 395                 400           

gat tcc ggc tat gac agc ctt gat ggg gtg gga tcg cga tcg ttc tcg       1248
Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly Ser Arg Ser Phe Ser           
                405                 410                 415               

ttg ggc gag gtg tcc gac atg gcc gcc gtg gaa gcg gcg gaa ctg gaa       1296
Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu Ala Ala Glu Leu Glu           
            420                 425                 430                   

atg acc cgg caa gtc ttg cac gcc ggg gcg cgg cag gac gat gcc gag       1344
Met Thr Arg Gln Val Leu His Ala Gly Ala Arg Gln Asp Asp Ala Glu           
        435                 440                 445                       

ccg ggc gtg agc ggt gcg tcg gcg cac tgg ggg cag cgg gcg ctg cag       1392
Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly Gln Arg Ala Leu Gln           
    450                 455                 460                           

ggc gcc cag gcg gtg gcg gcg gcg cag cgg ctg gtt cat gcc att gcc       1440
Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu Val His Ala Ile Ala           
465                 470                 475                 480           

ctg atg acg caa ttc ggc cgg gcc ggt tcc acc aac acg ccg cag gaa       1488
Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr Asn Thr Pro Gln Glu           
                485                 490                 495               

gcg gcc tcg ttg tcg gcg gcc gtg ttc ggc ttg ggc gag gcc agc agc       1536
Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu Gly Glu Ala Ser Ser           
            500                 505                 510                   

gcc gtg gcc gaa acc gtg agc ggt ttt ttc cgc ggg tct tcg cgc tgg       1584
Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg Gly Ser Ser Arg Trp           
        515                 520                 525                       

gcc ggc ggt ttc ggc gtg gct ggc ggc gcg atg gcg ctg gga ggc ggc       1632
Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met Ala Leu Gly Gly Gly           
    530                 535                 540                           

atc gcc gcg gcc gtt ggc gcc ggg atg tcg ttg acc gat gac gcg ccg       1680
Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu Thr Asp Asp Ala Pro           
545                 550                 555                 560           

gcc gga cag aag gcc gcc gtc ggc gcc gag atc gcg ctg cag ttg aca       1728
Ala Gly Gln Lys Ala Ala Val Gly Ala Glu Ile Ala Leu Gln Leu Thr           
                565                 570                 575               

ggt gga acg gtc gag ctg gct tct tcc atc gcg ttg gcg ctg gcc gcg       1776
Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu Ala Leu Ala Ala           
            580                 585                 590                   

gcg cgc ggc gtg acc agc ggc ttg cag gtg gcg ggg gcg tcg gcc ggg       1824
Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly Ala Ser Ala Gly           
        595                 600                 605                       

gcg gct gcc ggc gca ttg gcc gcg gcg ctc agt ccc atg gag atc tac       1872
Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro Met Glu Ile Tyr           
    610                 615                 620                           

ggc ctg gtg cag caa tcg cac tat gcg gat cag ctg gac aag ctg gcg       1920
Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu Asp Lys Leu Ala           
625                 630                 635                 640           

cag gaa tcg agc gca tac ggt tac gag ggc gac gcc ttg ctg gcc cag       1968
Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala Leu Leu Ala Gln           
                645                 650                 655               

ctg tat cgc gac aag acg gcc gcc gag ggc gcc gtc gcc ggc gtc tcc       2016
Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val Ala Gly Val Ser           
            660                 665                 670                   

gcc gtc ctg agc acg gtg ggg gcg gcg gtg tcg atc gcc gcg gcg gcc       2064
Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile Ala Ala Ala Ala           
        675                 680                 685                       

agc gtg gta ggc gcc ccg gtg gcg gtg gtc act tcc ttg ttg acc ggg       2112
Ser Val Val Gly Ala Pro Val Ala Val Val Thr Ser Leu Leu Thr Gly           
    690                 695                 700                           

gct ctc aac ggc atc ctg cgc ggc gtg cag cag ccc atc atc gaa aag       2160
Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro Ile Ile Glu Lys           
705                 710                 715                 720           

ctg gcc aat gat tac gct cgc aag atc gac gag ctg ggc ggg ccg caa       2208
Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu Gly Gly Pro Gln           
                725                 730                 735               

gcg tac ttc gag aaa aac ctg cag gcg cgt cac gaa caa ctg gcc aat       2256
Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu Gln Leu Ala Asn           
            740                 745                 750                   

tcg gac ggc cta cgg aaa atg ctg gct gac ctg cag gcc ggg tgg aac       2304
Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln Ala Gly Trp Asn           
        755                 760                 765                       

gcc agc agc gtg atc ggg gtg cag acg aca gag att tcc aag tcg gcg       2352
Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile Ser Lys Ser Ala           
    770                 775                 780                           

ctc gaa ctg gcc gcc att acc ggc aac gcg gac aac ctg aaa tcc gcc       2400
Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn Leu Lys Ser Ala           
785                 790                 795                 800           

gac gtg ttc gtg gac cgc ttc atc cag ggc gag cgg gtg gcc ggc cag       2448
Asp Val Phe Val Asp Arg Phe Ile Gln Gly Glu Arg Val Ala Gly Gln           
                805                 810                 815               

ccg gtg gta ctc gac gtc gcc gcc ggc ggc atc gat atc gcc agc cgc       2496
Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp Ile Ala Ser Arg           
            820                 825                 830                   

aag ggc gag cgg ccg gcg ctg acg ttc atc acg ccg ctg gcc gcg cca       2544
Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro Leu Ala Ala Pro           
        835                 840                 845                       

gga gaa gag cag cgc cgg cgc acg aag acg ggc aag agc gaa ttc acc       2592
Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys Ser Glu Phe Thr           
    850                 855                 860                           

aca ttc gtc gag atc gtg ggc aag cag gac cgc tgg cgc atc cgg gac       2640
Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp Arg Ile Arg Asp           
865                 870                 875                 880           

ggc gcg gcc gac acc acc atc gat ctg gcc aag gtg gtg tcg caa ctg       2688
Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val Val Ser Gln Leu           
                885                 890                 895               

gtc gac gcc aat ggc gtg ctc aag cac agc atc aaa ctg gag gtg atc       2736
Val Asp Ala Asn Gly Val Leu Lys His Ser Ile Lys Leu Glu Val Ile           
            900                 905                 910                   

ggc gga gat ggc gat gat gtc gtg ctt gcc aat gct tcg cgc atc cat       2784
Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn Ala Ser Arg Ile His           
        915                 920                 925                       

tac gac ggc ggc gcg gga acc aac acg gtc agc tat gcc gcc ctg ggc       2832
Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser Tyr Ala Ala Leu Gly           
    930                 935                 940                           

cga cag gat tcc att acc gtg tcc gcc gac ggg gaa cgt ttc aac gtg       2880
Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly Glu Arg Phe Asn Val           
945                 950                 955                 960           

cgc aag cag ttg aac aac gcc aac gtg tat cgc gaa ggc gtg gct acc       2928
Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg Glu Gly Val Ala Thr           
                965                 970                 975               

cag aaa acc gcc tac ggc aag cgc acg gag aat gtc caa tac cgc cat       2976
Gln Lys Thr Ala Tyr Gly Lys Arg Thr Glu Asn Val Gln Tyr Arg His           
            980                 985                 990                   

gtc gag ctg gcc cgt gtc ggg caa  ctg gtg gag gtc gac  acg ctc gag     3024
Val Glu Leu Ala Arg Val Gly Gln  Leu Val Glu Val Asp  Thr Leu Glu         
        995                 1000                 1005                     

cat gtg  cag cac atc atc ggc  ggg gcc ggc aac gat  tcg atc acc        3069
His Val  Gln His Ile Ile Gly  Gly Ala Gly Asn Asp  Ser Ile Thr            
    1010                 1015                 1020                        

ggc aat  gcg cac gac aac ttc  ctg gcc ggc ggg gcg  ggc gac gac        3114
Gly Asn  Ala His Asp Asn Phe  Leu Ala Gly Gly Ala  Gly Asp Asp            
    1025                 1030                 1035                        

agg ctg  gat ggc ggc gcc ggc  aac gac aca ctg gtc  ggc ggc gag        3159
Arg Leu  Asp Gly Gly Ala Gly  Asn Asp Thr Leu Val  Gly Gly Glu            
    1040                 1045                 1050                        

ggc cac  aac acg gtc gtc ggc  ggc gct ggc gac gac  gta ttc ctg        3204
Gly His  Asn Thr Val Val Gly  Gly Ala Gly Asp Asp  Val Phe Leu            
    1055                 1060                 1065                        

cag gac  ctg ggg gta tgg agc  aac cag ctc gat ggc  ggc gcg ggc        3249
Gln Asp  Leu Gly Val Trp Ser  Asn Gln Leu Asp Gly  Gly Ala Gly            
    1070                 1075                 1080                        

gtc gat  acc gtg aag tac aac  gtg cac cag cct tcc  gag gaa cgc        3294
Val Asp  Thr Val Lys Tyr Asn  Val His Gln Pro Ser  Glu Glu Arg            
    1085                 1090                 1095                        

ctc gaa  cgc atg ggc gac acg  ggc atc cat gcc gat  ctt caa aag        3339
Leu Glu  Arg Met Gly Asp Thr  Gly Ile His Ala Asp  Leu Gln Lys            
    1100                 1105                 1110                        

ggc acg  gtc gag aag tgg ccg  gcc ctg aac ctg ttc  agc gtc gac        3384
Gly Thr  Val Glu Lys Trp Pro  Ala Leu Asn Leu Phe  Ser Val Asp            
    1115                 1120                 1125                        

cat gtc  aag aat atc gag aat  ctg cac ggc tcc agc  ctg aac gac        3429
His Val  Lys Asn Ile Glu Asn  Leu His Gly Ser Ser  Leu Asn Asp            
    1130                 1135                 1140                        

agc atc  gcc ggc gac gac cgg  gac aac gag ctc tgg  ggc gac gat        3474
Ser Ile  Ala Gly Asp Asp Arg  Asp Asn Glu Leu Trp  Gly Asp Asp            
    1145                 1150                 1155                        

ggc aac  gac acg ata cac ggc  cgg ggc ggc gac gat  atc ctg cgc        3519
Gly Asn  Asp Thr Ile His Gly  Arg Gly Gly Asp Asp  Ile Leu Arg            
    1160                 1165                 1170                        

ggc ggc  ctg ggc ctg gac acg  ctg tat ggc gag gac  ggc aac gac        3564
Gly Gly  Leu Gly Leu Asp Thr  Leu Tyr Gly Glu Asp  Gly Asn Asp            
    1175                 1180                 1185                        

atc ttc  ctg cag gac gac gag  acc gtc agc gat gac  atc gac ggc        3609
Ile Phe  Leu Gln Asp Asp Glu  Thr Val Ser Asp Asp  Ile Asp Gly            
    1190                 1195                 1200                        

ggc gcg  ggg ctg gac acc gtc  gac tat tcc gcc atg  atc cat gca        3654
Gly Ala  Gly Leu Asp Thr Val  Asp Tyr Ser Ala Met  Ile His Ala            
    1205                 1210                 1215                        

ggc aag  atc gtt gcg ccg cat  gaa tac ggc ttc ggg  atc gag gcg        3699
Gly Lys  Ile Val Ala Pro His  Glu Tyr Gly Phe Gly  Ile Glu Ala            
    1220                 1225                 1230                        

gac ctg  tcc gaa ggg tgg gtg  cgc aag gcg gcc cgg  cgc ggc atg        3744
Asp Leu  Ser Glu Gly Trp Val  Arg Lys Ala Ala Arg  Arg Gly Met            
    1235                 1240                 1245                        

ggc tac  tac gac agt gtc cgc  agt gtc gaa aac gtc  atc ggc acg        3789
Gly Tyr  Tyr Asp Ser Val Arg  Ser Val Glu Asn Val  Ile Gly Thr            
    1250                 1255                 1260                        

agc atg  aag gat gtg ctc atc  ggc gac gcg caa gcc  aat acc ctg        3834
Ser Met  Lys Asp Val Leu Ile  Gly Asp Ala Gln Ala  Asn Thr Leu            
    1265                 1270                 1275                        

atg ggc  cag ggc ggc gac gat  acc gtg cgc ggc ggc  gac ggc gat        3879
Met Gly  Gln Gly Gly Asp Asp  Thr Val Arg Gly Gly  Asp Gly Asp            
    1280                 1285                 1290                        

gat ctg  ctg ttc ggc ggc gac  ggc aac gac atg ctg  tat gga gac        3924
Asp Leu  Leu Phe Gly Gly Asp  Gly Asn Asp Met Leu  Tyr Gly Asp            
    1295                 1300                 1305                        

gcc ggc  aac gac acc ctc tac  gga ggg ctg ggc gac  gat acc ctt        3969
Ala Gly  Asn Asp Thr Leu Tyr  Gly Gly Leu Gly Asp  Asp Thr Leu            
    1310                 1315                 1320                        

gaa ggc  ggc gcg ggc aac gat  tgg ttc ggc cag acg  ccg gcg cgc        4014
Glu Gly  Gly Ala Gly Asn Asp  Trp Phe Gly Gln Thr  Pro Ala Arg            
    1325                 1330                 1335                        

gag cat  gac gtg ctg cgc ggc  ggg gct ggg gtg gat  acc gtg gat        4059
Glu His  Asp Val Leu Arg Gly  Gly Ala Gly Val Asp  Thr Val Asp            
    1340                 1345                 1350                        

tac agc  cag gcg ggc gcg cat  gcc ggc gtt gcc acg  ggt cgc atc        4104
Tyr Ser  Gln Ala Gly Ala His  Ala Gly Val Ala Thr  Gly Arg Ile            
    1355                 1360                 1365                        

ggg ctg  ggt att ctg gcg gac  ctg ggc gcc ggc cgc  gtc gac aag        4149
Gly Leu  Gly Ile Leu Ala Asp  Leu Gly Ala Gly Arg  Val Asp Lys            
    1370                 1375                 1380                        

ctg ggc  gag gcc ggc agc agc  gcc tac gat acg gtt  tcc ggc atc        4194
Leu Gly  Glu Ala Gly Ser Ser  Ala Tyr Asp Thr Val  Ser Gly Ile            
    1385                 1390                 1395                        

gaa aat  gtg gtg ggc acg gaa  ctg gcc gac cgc atc  acg ggc gat        4239
Glu Asn  Val Val Gly Thr Glu  Leu Ala Asp Arg Ile  Thr Gly Asp            
    1400                 1405                 1410                        

gcg cag  gcc aac gta ctg cgc  ggc gcg ggt ggt gcc  gac gtg ctt        4284
Ala Gln  Ala Asn Val Leu Arg  Gly Ala Gly Gly Ala  Asp Val Leu            
    1415                 1420                 1425                        

gcg ggc  ggc gag ggc gac gat  gtg ctg ctg ggc ggc  gag ggc gat        4329
Ala Gly  Gly Glu Gly Asp Asp  Val Leu Leu Gly Gly  Glu Gly Asp            
    1430                 1435                 1440                        

gac cag  ctg tcg ggc gac gcc  gga cgc gac cgc ttg  tac ggc gaa        4374
Asp Gln  Leu Ser Gly Asp Ala  Gly Arg Asp Arg Leu  Tyr Gly Glu            
    1445                 1450                 1455                        

gcc ggt  gac gac tgg ttc ttc  cag gat gcc gcc aat  gcc ggc aat        4419
Ala Gly  Asp Asp Trp Phe Phe  Gln Asp Ala Ala Asn  Ala Gly Asn            
    1460                 1465                 1470                        

ctg ctc  gac ggt ggt gac ggc  aac gat acc gtg gat  ttc agc ggc        4464
Leu Leu  Asp Gly Gly Asp Gly  Asn Asp Thr Val Asp  Phe Ser Gly            
    1475                 1480                 1485                        

ccg ggc  cgg ggc ctc gac gcc  ggc gca aag ggc gta  ttc ctg agc        4509
Pro Gly  Arg Gly Leu Asp Ala  Gly Ala Lys Gly Val  Phe Leu Ser            
    1490                 1495                 1500                        

ctg ggc  aag ggg ttc gcc agc  ctg atg gac gaa ccc  gaa acc agc        4554
Leu Gly  Lys Gly Phe Ala Ser  Leu Met Asp Glu Pro  Glu Thr Ser            
    1505                 1510                 1515                        

aac gtg  ttg cgc cat atc gag  aac gcc gtg ggc agc  gtg cgt gat        4599
Asn Val  Leu Arg His Ile Glu  Asn Ala Val Gly Ser  Val Arg Asp            
    1520                 1525                 1530                        

gac gtg  ctg atc ggc gac gca  ggc gcc aac gtc ctc  aat ggc ctg        4644
Asp Val  Leu Ile Gly Asp Ala  Gly Ala Asn Val Leu  Asn Gly Leu            
    1535                 1540                 1545                        

gcg ggc  aac gac gtg ttg tcc  ggc ggc gcc ggc gac  gat gtg ctg        4689
Ala Gly  Asn Asp Val Leu Ser  Gly Gly Ala Gly Asp  Asp Val Leu            
    1550                 1555                 1560                        

ctg ggc  gac gag ggc tcg gac  ctg ctc agc ggc gat  gcg ggc aac        4734
Leu Gly  Asp Glu Gly Ser Asp  Leu Leu Ser Gly Asp  Ala Gly Asn            
    1565                 1570                 1575                        

gac gat  ctg ttc ggc ggg cag  ggc gat gat acc tat  ctg ttc ggg        4779
Asp Asp  Leu Phe Gly Gly Gln  Gly Asp Asp Thr Tyr  Leu Phe Gly            
    1580                 1585                 1590                        

gcc ggg  tac gga cat gac acg  atc tac gaa tcg ggc  ggc ggc cat        4824
Ala Gly  Tyr Gly His Asp Thr  Ile Tyr Glu Ser Gly  Gly Gly His            
    1595                 1600                 1605                        

gac acc  atc cgt atc aac gcg  ggg gcg gac cag ctg  tgg ttt gcg        4869
Asp Thr  Ile Arg Ile Asn Ala  Gly Ala Asp Gln Leu  Trp Phe Ala            
    1610                 1615                 1620                        

cgc cag  ggc aac gac ctg gag  atc cgc att ctt ggc  acc gac gat        4914
Arg Gln  Gly Asn Asp Leu Glu  Ile Arg Ile Leu Gly  Thr Asp Asp            
    1625                 1630                 1635                        

gca ctt  acc gtg cac gac tgg  tat cgc gac gcc gat  cac cgg gtg        4959
Ala Leu  Thr Val His Asp Trp  Tyr Arg Asp Ala Asp  His Arg Val            
    1640                 1645                 1650                        

gaa gcc  atc cat gcc gcc aac  cag gcc ata gac ccg  gcc ggc atc        5004
Glu Ala  Ile His Ala Ala Asn  Gln Ala Ile Asp Pro  Ala Gly Ile            
    1655                 1660                 1665                        

gaa aag  ctg gtc gag gca atg  gcg cag tac ccg gac  ccc ggc gcg        5049
Glu Lys  Leu Val Glu Ala Met  Ala Gln Tyr Pro Asp  Pro Gly Ala            
    1670                 1675                 1680                        

gcg gcg  gct gcc ccg ccg gcg  gcg cgc gtg ccg gac  acg ctg atg        5094
Ala Ala  Ala Ala Pro Pro Ala  Ala Arg Val Pro Asp  Thr Leu Met            
    1685                 1690                 1695                        

cag tcc  ctg gct gtc aac tgg  cgc tga                                 5121
Gln Ser  Leu Ala Val Asn Trp  Arg                                         
    1700                 1705                                             


<210>  6
<211>  1706
<212>  PRT
<213>  Bordetella parapertussis (wild type CyaA)

<400>  6

Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu 
1               5                   10                  15      


Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys 
            20                  25                  30          


Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr 
        35                  40                  45              


Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala 
    50                  55                  60                  


Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro 
65                  70                  75                  80  


Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala 
                85                  90                  95      


Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp 
            100                 105                 110         


Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu 
        115                 120                 125             


Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr 
    130                 135                 140                 


Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala 
145                 150                 155                 160 


Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val 
                165                 170                 175     


Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe 
            180                 185                 190         


Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser 
        195                 200                 205             


Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg 
    210                 215                 220                 


Ala Ala Ser Glu Ala Thr Gly Gly Leu Asp Arg Glu Arg Ile Asp Leu 
225                 230                 235                 240 


Leu Trp Lys Ile Ala Arg Ala Gly Ala Arg Ser Ala Val Gly Thr Glu 
                245                 250                 255     


Ala Arg Arg Gln Phe Arg Tyr Asp Gly Asp Met Asn Ile Gly Val Ile 
            260                 265                 270         


Thr Asp Phe Glu Leu Glu Val Arg Asn Ala Leu Asn Arg Arg Ala His 
        275                 280                 285             


Ala Val Gly Ala Gln Asp Val Val Gln His Gly Thr Glu Gln Asn Asn 
    290                 295                 300                 


Pro Phe Pro Glu Ala Asp Glu Lys Ile Phe Val Val Ser Ala Thr Gly 
305                 310                 315                 320 


Glu Ser Gln Met Leu Thr Arg Gly Gln Leu Lys Glu Tyr Ile Gly Gln 
                325                 330                 335     


Gln Arg Gly Glu Gly Tyr Val Phe Tyr Glu Asn Arg Ala Tyr Gly Val 
            340                 345                 350         


Ala Gly Lys Ser Leu Phe Asp Asp Gly Leu Gly Ala Ala Pro Gly Val 
        355                 360                 365             


Pro Gly Gly Arg Ser Lys Ser Ser Pro Asp Val Leu Glu Thr Val Pro 
    370                 375                 380                 


Ala Ser Pro Gly Leu Arg Arg Pro Ser Leu Gly Ala Val Glu Arg Gln 
385                 390                 395                 400 


Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly Ser Arg Ser Phe Ser 
                405                 410                 415     


Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu Ala Ala Glu Leu Glu 
            420                 425                 430         


Met Thr Arg Gln Val Leu His Ala Gly Ala Arg Gln Asp Asp Ala Glu 
        435                 440                 445             


Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly Gln Arg Ala Leu Gln 
    450                 455                 460                 


Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu Val His Ala Ile Ala 
465                 470                 475                 480 


Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr Asn Thr Pro Gln Glu 
                485                 490                 495     


Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu Gly Glu Ala Ser Ser 
            500                 505                 510         


Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg Gly Ser Ser Arg Trp 
        515                 520                 525             


Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met Ala Leu Gly Gly Gly 
    530                 535                 540                 


Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu Thr Asp Asp Ala Pro 
545                 550                 555                 560 


Ala Gly Gln Lys Ala Ala Val Gly Ala Glu Ile Ala Leu Gln Leu Thr 
                565                 570                 575     


Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu Ala Leu Ala Ala 
            580                 585                 590         


Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly Ala Ser Ala Gly 
        595                 600                 605             


Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro Met Glu Ile Tyr 
    610                 615                 620                 


Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu Asp Lys Leu Ala 
625                 630                 635                 640 


Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala Leu Leu Ala Gln 
                645                 650                 655     


Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val Ala Gly Val Ser 
            660                 665                 670         


Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile Ala Ala Ala Ala 
        675                 680                 685             


Ser Val Val Gly Ala Pro Val Ala Val Val Thr Ser Leu Leu Thr Gly 
    690                 695                 700                 


Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro Ile Ile Glu Lys 
705                 710                 715                 720 


Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu Gly Gly Pro Gln 
                725                 730                 735     


Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu Gln Leu Ala Asn 
            740                 745                 750         


Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln Ala Gly Trp Asn 
        755                 760                 765             


Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile Ser Lys Ser Ala 
    770                 775                 780                 


Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn Leu Lys Ser Ala 
785                 790                 795                 800 


Asp Val Phe Val Asp Arg Phe Ile Gln Gly Glu Arg Val Ala Gly Gln 
                805                 810                 815     


Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp Ile Ala Ser Arg 
            820                 825                 830         


Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro Leu Ala Ala Pro 
        835                 840                 845             


Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys Ser Glu Phe Thr 
    850                 855                 860                 


Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp Arg Ile Arg Asp 
865                 870                 875                 880 


Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val Val Ser Gln Leu 
                885                 890                 895     


Val Asp Ala Asn Gly Val Leu Lys His Ser Ile Lys Leu Glu Val Ile 
            900                 905                 910         


Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn Ala Ser Arg Ile His 
        915                 920                 925             


Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser Tyr Ala Ala Leu Gly 
    930                 935                 940                 


Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly Glu Arg Phe Asn Val 
945                 950                 955                 960 


Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg Glu Gly Val Ala Thr 
                965                 970                 975     


Gln Lys Thr Ala Tyr Gly Lys Arg Thr Glu Asn Val Gln Tyr Arg His 
            980                 985                 990         


Val Glu Leu Ala Arg Val Gly Gln  Leu Val Glu Val Asp  Thr Leu Glu 
        995                 1000                 1005             


His Val  Gln His Ile Ile Gly  Gly Ala Gly Asn Asp  Ser Ile Thr 
    1010                 1015                 1020             


Gly Asn  Ala His Asp Asn Phe  Leu Ala Gly Gly Ala  Gly Asp Asp 
    1025                 1030                 1035             


Arg Leu  Asp Gly Gly Ala Gly  Asn Asp Thr Leu Val  Gly Gly Glu 
    1040                 1045                 1050             


Gly His  Asn Thr Val Val Gly  Gly Ala Gly Asp Asp  Val Phe Leu 
    1055                 1060                 1065             


Gln Asp  Leu Gly Val Trp Ser  Asn Gln Leu Asp Gly  Gly Ala Gly 
    1070                 1075                 1080             


Val Asp  Thr Val Lys Tyr Asn  Val His Gln Pro Ser  Glu Glu Arg 
    1085                 1090                 1095             


Leu Glu  Arg Met Gly Asp Thr  Gly Ile His Ala Asp  Leu Gln Lys 
    1100                 1105                 1110             


Gly Thr  Val Glu Lys Trp Pro  Ala Leu Asn Leu Phe  Ser Val Asp 
    1115                 1120                 1125             


His Val  Lys Asn Ile Glu Asn  Leu His Gly Ser Ser  Leu Asn Asp 
    1130                 1135                 1140             


Ser Ile  Ala Gly Asp Asp Arg  Asp Asn Glu Leu Trp  Gly Asp Asp 
    1145                 1150                 1155             


Gly Asn  Asp Thr Ile His Gly  Arg Gly Gly Asp Asp  Ile Leu Arg 
    1160                 1165                 1170             


Gly Gly  Leu Gly Leu Asp Thr  Leu Tyr Gly Glu Asp  Gly Asn Asp 
    1175                 1180                 1185             


Ile Phe  Leu Gln Asp Asp Glu  Thr Val Ser Asp Asp  Ile Asp Gly 
    1190                 1195                 1200             


Gly Ala  Gly Leu Asp Thr Val  Asp Tyr Ser Ala Met  Ile His Ala 
    1205                 1210                 1215             


Gly Lys  Ile Val Ala Pro His  Glu Tyr Gly Phe Gly  Ile Glu Ala 
    1220                 1225                 1230             


Asp Leu  Ser Glu Gly Trp Val  Arg Lys Ala Ala Arg  Arg Gly Met 
    1235                 1240                 1245             


Gly Tyr  Tyr Asp Ser Val Arg  Ser Val Glu Asn Val  Ile Gly Thr 
    1250                 1255                 1260             


Ser Met  Lys Asp Val Leu Ile  Gly Asp Ala Gln Ala  Asn Thr Leu 
    1265                 1270                 1275             


Met Gly  Gln Gly Gly Asp Asp  Thr Val Arg Gly Gly  Asp Gly Asp 
    1280                 1285                 1290             


Asp Leu  Leu Phe Gly Gly Asp  Gly Asn Asp Met Leu  Tyr Gly Asp 
    1295                 1300                 1305             


Ala Gly  Asn Asp Thr Leu Tyr  Gly Gly Leu Gly Asp  Asp Thr Leu 
    1310                 1315                 1320             


Glu Gly  Gly Ala Gly Asn Asp  Trp Phe Gly Gln Thr  Pro Ala Arg 
    1325                 1330                 1335             


Glu His  Asp Val Leu Arg Gly  Gly Ala Gly Val Asp  Thr Val Asp 
    1340                 1345                 1350             


Tyr Ser  Gln Ala Gly Ala His  Ala Gly Val Ala Thr  Gly Arg Ile 
    1355                 1360                 1365             


Gly Leu  Gly Ile Leu Ala Asp  Leu Gly Ala Gly Arg  Val Asp Lys 
    1370                 1375                 1380             


Leu Gly  Glu Ala Gly Ser Ser  Ala Tyr Asp Thr Val  Ser Gly Ile 
    1385                 1390                 1395             


Glu Asn  Val Val Gly Thr Glu  Leu Ala Asp Arg Ile  Thr Gly Asp 
    1400                 1405                 1410             


Ala Gln  Ala Asn Val Leu Arg  Gly Ala Gly Gly Ala  Asp Val Leu 
    1415                 1420                 1425             


Ala Gly  Gly Glu Gly Asp Asp  Val Leu Leu Gly Gly  Glu Gly Asp 
    1430                 1435                 1440             


Asp Gln  Leu Ser Gly Asp Ala  Gly Arg Asp Arg Leu  Tyr Gly Glu 
    1445                 1450                 1455             


Ala Gly  Asp Asp Trp Phe Phe  Gln Asp Ala Ala Asn  Ala Gly Asn 
    1460                 1465                 1470             


Leu Leu  Asp Gly Gly Asp Gly  Asn Asp Thr Val Asp  Phe Ser Gly 
    1475                 1480                 1485             


Pro Gly  Arg Gly Leu Asp Ala  Gly Ala Lys Gly Val  Phe Leu Ser 
    1490                 1495                 1500             


Leu Gly  Lys Gly Phe Ala Ser  Leu Met Asp Glu Pro  Glu Thr Ser 
    1505                 1510                 1515             


Asn Val  Leu Arg His Ile Glu  Asn Ala Val Gly Ser  Val Arg Asp 
    1520                 1525                 1530             


Asp Val  Leu Ile Gly Asp Ala  Gly Ala Asn Val Leu  Asn Gly Leu 
    1535                 1540                 1545             


Ala Gly  Asn Asp Val Leu Ser  Gly Gly Ala Gly Asp  Asp Val Leu 
    1550                 1555                 1560             


Leu Gly  Asp Glu Gly Ser Asp  Leu Leu Ser Gly Asp  Ala Gly Asn 
    1565                 1570                 1575             


Asp Asp  Leu Phe Gly Gly Gln  Gly Asp Asp Thr Tyr  Leu Phe Gly 
    1580                 1585                 1590             


Ala Gly  Tyr Gly His Asp Thr  Ile Tyr Glu Ser Gly  Gly Gly His 
    1595                 1600                 1605             


Asp Thr  Ile Arg Ile Asn Ala  Gly Ala Asp Gln Leu  Trp Phe Ala 
    1610                 1615                 1620             


Arg Gln  Gly Asn Asp Leu Glu  Ile Arg Ile Leu Gly  Thr Asp Asp 
    1625                 1630                 1635             


Ala Leu  Thr Val His Asp Trp  Tyr Arg Asp Ala Asp  His Arg Val 
    1640                 1645                 1650             


Glu Ala  Ile His Ala Ala Asn  Gln Ala Ile Asp Pro  Ala Gly Ile 
    1655                 1660                 1665             


Glu Lys  Leu Val Glu Ala Met  Ala Gln Tyr Pro Asp  Pro Gly Ala 
    1670                 1675                 1680             


Ala Ala  Ala Ala Pro Pro Ala  Ala Arg Val Pro Asp  Thr Leu Met 
    1685                 1690                 1695             


Gln Ser  Leu Ala Val Asn Trp  Arg 
    1700                 1705     


<210>  7
<211>  5118
<212>  DNA
<213>  Bordetella bronchiseptica (wild type CyaA)


<220>
<221>  CDS
<222>  (1)..(5118)

<400>  7
atg cag caa tcg cat cag gct ggt tac gca aac gcc gcc gac cgg gag         48
Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu           
1               5                   10                  15                

tct ggc atc ccc gca gcc gta ctc gat ggc atc aag gcc gtg gcg aag         96
Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys           
            20                  25                  30                    

gaa aaa aac gcc aca ttg atg ttc cgc ctg gtc aac ccc cat tcc acc        144
Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr           
        35                  40                  45                        

agc ctg att gcc gaa ggg gtg gcc acc aaa gga ttg ggc gtg cac gcc        192
Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala           
    50                  55                  60                            

aag tcg tcc gat tgg ggg ttg cag gcg ggc tac att ccc gtc aac ccg        240
Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro           
65                  70                  75                  80            

aat ctt tcc aaa ctg ttc ggc cgt gcg ccc gag gtg atc gcg cgg gcc        288
Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala           
                85                  90                  95                

gac aac gac gtc aac agc agc ctg gcg cat ggc cat acc gcg gtc gac        336
Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp           
            100                 105                 110                   

ctg acg ctg tcg aaa gag cgg ctt gac tat ctg cgg caa gcg ggc ctg        384
Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu           
        115                 120                 125                       

gtc acc ggc atg gcc gat ggc gtg gtc gcg agc aac cac gca ggc tac        432
Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr           
    130                 135                 140                           

gag cag ttc gag ttt cgc gtg aag gaa acc tcg gac ggg cgc tat gcc        480
Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala           
145                 150                 155                 160           

gtg cag tat cgc cgc aag ggc ggc gac gat ttc gag gcg gtc aag gtg        528
Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val           
                165                 170                 175               

atc ggc aat gcc gcc ggt att cca ctg acg gcg gat atc gac atg ttc        576
Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe           
            180                 185                 190                   

gcc atc atg ccg cat ctg tcc aac ttc cgc gac tcg gcg cgc agt tcg        624
Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser           
        195                 200                 205                       

gtg acc agc ggc gat tcg gtg acc gat tac ctg gcg cgc acg cgg cgg        672
Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg           
    210                 215                 220                           

gcc gcc agc gag gcc acg ggc ggc ctg gat cgc gaa cgc atc gac ttg        720
Ala Ala Ser Glu Ala Thr Gly Gly Leu Asp Arg Glu Arg Ile Asp Leu           
225                 230                 235                 240           

ttg tgg aaa atc gct cgc gcc ggc gcc cgt tcc gca gtg ggc acc gag        768
Leu Trp Lys Ile Ala Arg Ala Gly Ala Arg Ser Ala Val Gly Thr Glu           
                245                 250                 255               

gcg cgt cgc cag ttc cgc tac gac ggc gac atg aat atc ggc gtg atc        816
Ala Arg Arg Gln Phe Arg Tyr Asp Gly Asp Met Asn Ile Gly Val Ile           
            260                 265                 270                   

acc gat ttc gag ctg gaa gtg cgc aat gcg ctg aac agg cgg gcg cac        864
Thr Asp Phe Glu Leu Glu Val Arg Asn Ala Leu Asn Arg Arg Ala His           
        275                 280                 285                       

gcg gtc ggc agg cag gac gtg gtc cag cat ggc act gag cag aac aat        912
Ala Val Gly Arg Gln Asp Val Val Gln His Gly Thr Glu Gln Asn Asn           
    290                 295                 300                           

cct ttc ccg gag gca gat gag aag att ttc gtc gta tcg gcc acc ggt        960
Pro Phe Pro Glu Ala Asp Glu Lys Ile Phe Val Val Ser Ala Thr Gly           
305                 310                 315                 320           

gaa agc cag atg ctc acg cgc ggg caa ctg aag gaa tac att ggc cag       1008
Glu Ser Gln Met Leu Thr Arg Gly Gln Leu Lys Glu Tyr Ile Gly Gln           
                325                 330                 335               

cag cgc ggc gag ggc tat gtc ttc tac gag aac cgt gcg tac ggc gtg       1056
Gln Arg Gly Glu Gly Tyr Val Phe Tyr Glu Asn Arg Ala Tyr Gly Val           
            340                 345                 350                   

gcg ggg aaa agc ctg ttc gac gat ggg ctg gga gcc gcg ccc ggc gtg       1104
Ala Gly Lys Ser Leu Phe Asp Asp Gly Leu Gly Ala Ala Pro Gly Val           
        355                 360                 365                       

ccg ggg cga cgt tcg aag tcc tcg ccg gat gta ctg gaa acg gtg ccg       1152
Pro Gly Arg Arg Ser Lys Ser Ser Pro Asp Val Leu Glu Thr Val Pro           
    370                 375                 380                           

gcg tca ccc gga ttg cgg cgg ccg tcg ctg ggc gca gtg gaa cgc cag       1200
Ala Ser Pro Gly Leu Arg Arg Pro Ser Leu Gly Ala Val Glu Arg Gln           
385                 390                 395                 400           

gat tcc ggc tat gac agc ctt gat ggg gtg gga tcg cga tcg ttc tcg       1248
Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly Ser Arg Ser Phe Ser           
                405                 410                 415               

ttg ggc gag gtg tcc gac atg gcc gcc gtg gaa gcg gcg gaa ctg gaa       1296
Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu Ala Ala Glu Leu Glu           
            420                 425                 430                   

atg acc cgg caa gtc ttg cac gcc ggg gcg cgg cag gac gat gcc gag       1344
Met Thr Arg Gln Val Leu His Ala Gly Ala Arg Gln Asp Asp Ala Glu           
        435                 440                 445                       

ccg ggc gtg agc ggt gcg tcg gcg cac tgg ggg cag cgg gcg ctg cag       1392
Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly Gln Arg Ala Leu Gln           
    450                 455                 460                           

ggc gcc cag gcg gtg gcg gcg gcg cag cgg ctg gtt cat gcc att gcc       1440
Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu Val His Ala Ile Ala           
465                 470                 475                 480           

ctg atg acg caa ttc ggc cgg gcc ggt tcc acc aac acg ccg cag gaa       1488
Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr Asn Thr Pro Gln Glu           
                485                 490                 495               

gcg gcc tcg ttg tcg gcg gcc gtg ttc ggc ttg ggc gag gcc agc agc       1536
Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu Gly Glu Ala Ser Ser           
            500                 505                 510                   

gcc gtg gcc gaa acc gtg agc ggt ttt ttc cgc ggg tct tcg cgc tgg       1584
Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg Gly Ser Ser Arg Trp           
        515                 520                 525                       

gcc ggc ggt ttc ggc gtg gct ggc ggc gcg atg gcg ctg gga ggc ggc       1632
Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met Ala Leu Gly Gly Gly           
    530                 535                 540                           

atc ggc gcc gtt ggc gcc ggg atg tcg ttg acc gat gac gcg ccg gcc       1680
Ile Gly Ala Val Gly Ala Gly Met Ser Leu Thr Asp Asp Ala Pro Ala           
545                 550                 555                 560           

gga cag aag gcc gcc gcc ggc gcc gag atc gcg ctg cag ttg aca ggt       1728
Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile Ala Leu Gln Leu Thr Gly           
                565                 570                 575               

gga acg gtc gag ctg gct tct tcc atc gcg ttg gcg ctg gcc gcg gcg       1776
Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu Ala Leu Ala Ala Ala           
            580                 585                 590                   

cgc ggc gtg acc agc ggc ttg cag gtg gcg ggg gcg tcg gcc ggg gcg       1824
Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly Ala Ser Ala Gly Ala           
        595                 600                 605                       

gct gcc ggc gca ttg gcc gcg gcg ctc agt ccc atg gag atc tac ggc       1872
Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro Met Glu Ile Tyr Gly           
    610                 615                 620                           

ctg gtg cag caa tcg cac tat gcg gat cag ctg gac aag ctg gcg cag       1920
Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu Asp Lys Leu Ala Gln           
625                 630                 635                 640           

gaa tcg agc gca tac ggt tac gag ggc gac gcc ttg ctg gcc cag ctg       1968
Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala Leu Leu Ala Gln Leu           
                645                 650                 655               

tat cgc gac aag acg gcc gcc gag ggc gcc gtc gcc ggc gtc tcc gcc       2016
Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val Ala Gly Val Ser Ala           
            660                 665                 670                   

gtc ctg agc acg gtg ggg gct gcg gtg tcg atc gcc gcg gcg gcc agc       2064
Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile Ala Ala Ala Ala Ser           
        675                 680                 685                       

gtg gta ggc gcc ccg gtg gcg gtg gtc act tcc ttg ttg acc ggg gct       2112
Val Val Gly Ala Pro Val Ala Val Val Thr Ser Leu Leu Thr Gly Ala           
    690                 695                 700                           

ctc aac ggc atc ctg cgc ggc gtg cag cag ccc atc atc gaa aag ctg       2160
Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro Ile Ile Glu Lys Leu           
705                 710                 715                 720           

gcc aat gat tac gct cgc aag atc gac gag ctg ggc ggg ccg caa gcg       2208
Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu Gly Gly Pro Gln Ala           
                725                 730                 735               

tac ttc gag aaa aac ctg cag gcg cgt cac gaa caa ctg gcc aat tcg       2256
Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu Gln Leu Ala Asn Ser           
            740                 745                 750                   

gac ggc cta cgg aaa atg ctg gcc gac ctg cag gcc ggg tgg aac gcc       2304
Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln Ala Gly Trp Asn Ala           
        755                 760                 765                       

agc agc gtg atc ggg gtg cag acg aca gag att tcc aag tcg gcg ctc       2352
Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile Ser Lys Ser Ala Leu           
    770                 775                 780                           

gaa ctg gcc gcc att acc ggc aac gcg gac aac ctg aaa tcc gcc gac       2400
Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn Leu Lys Ser Ala Asp           
785                 790                 795                 800           

gtg ttc gtg gac cgc ttc atc cag ggc gag cgg gtg gcc ggc cag ccg       2448
Val Phe Val Asp Arg Phe Ile Gln Gly Glu Arg Val Ala Gly Gln Pro           
                805                 810                 815               

gtg gta ctc gac gtc gcc gcc ggc ggc atc gat atc gcc agc cgc aag       2496
Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp Ile Ala Ser Arg Lys           
            820                 825                 830                   

ggc gag cgg ccg gcg ctg acg ttc atc acg ccg ctg gcc gcg cca gga       2544
Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro Leu Ala Ala Pro Gly           
        835                 840                 845                       

gaa gag cag cgc cgg cgc acg aaa acg ggc aag agc gaa ttc acc aca       2592
Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys Ser Glu Phe Thr Thr           
    850                 855                 860                           

ttc gtc gag atc gtg ggc aag cag gac cgc tgg cgc atc cgg gac ggc       2640
Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp Arg Ile Arg Asp Gly           
865                 870                 875                 880           

gcg gcc gac acc acc atc gat ctg gcc aag gtg gtg tcg caa ctg gtc       2688
Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val Val Ser Gln Leu Val           
                885                 890                 895               

gac gcc aat ggc gtg ctc aag cac agc atc aaa ctg gag gtg atc ggc       2736
Asp Ala Asn Gly Val Leu Lys His Ser Ile Lys Leu Glu Val Ile Gly           
            900                 905                 910                   

gga gat ggc gat gat gtc gtg ctt gcc aat gct tcg cgc atc cat tac       2784
Gly Asp Gly Asp Asp Val Val Leu Ala Asn Ala Ser Arg Ile His Tyr           
        915                 920                 925                       

gac ggc ggc gcg gga acc aac acg gtc agc tat gcc gcc ctg ggc cga       2832
Asp Gly Gly Ala Gly Thr Asn Thr Val Ser Tyr Ala Ala Leu Gly Arg           
    930                 935                 940                           

cag gat tcc att acc gtg tcc gcc gac ggg gaa cgt ttc aac gtg cgc       2880
Gln Asp Ser Ile Thr Val Ser Ala Asp Gly Glu Arg Phe Asn Val Arg           
945                 950                 955                 960           

aag cag ttg aac aac gcc aac gtg tat cgc gaa ggc gtg gct acc cag       2928
Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg Glu Gly Val Ala Thr Gln           
                965                 970                 975               

aaa acc gcc tac ggc aag cgc acg gag aat gtc caa tac cgc cat gtc       2976
Lys Thr Ala Tyr Gly Lys Arg Thr Glu Asn Val Gln Tyr Arg His Val           
            980                 985                 990                   

gag ctg gcc cgt gtc ggg caa ctg  gtg gag gtc gac acg  ctc gag cat     3024
Glu Leu Ala Arg Val Gly Gln Leu  Val Glu Val Asp Thr  Leu Glu His         
        995                 1000                 1005                     

gtg cag  cac atc atc ggc ggg  gcc ggc aac gat tcg  atc acc ggc        3069
Val Gln  His Ile Ile Gly Gly  Ala Gly Asn Asp Ser  Ile Thr Gly            
    1010                 1015                 1020                        

aat gcg  cac gac aac ttc ctg  gcc ggc ggg gcg ggc  gac gac agg        3114
Asn Ala  His Asp Asn Phe Leu  Ala Gly Gly Ala Gly  Asp Asp Arg            
    1025                 1030                 1035                        

ctg gat  ggc ggc gcc ggc aac  gac aca ctg gtc ggc  ggc gag ggc        3159
Leu Asp  Gly Gly Ala Gly Asn  Asp Thr Leu Val Gly  Gly Glu Gly            
    1040                 1045                 1050                        

cac aac  acg gtc gtc ggc ggc  gct ggc gac gac gta  ttc ctg cag        3204
His Asn  Thr Val Val Gly Gly  Ala Gly Asp Asp Val  Phe Leu Gln            
    1055                 1060                 1065                        

gac ctg  ggg gta tgg agc aac  cag ctc gat ggc ggc  gcg ggc gtc        3249
Asp Leu  Gly Val Trp Ser Asn  Gln Leu Asp Gly Gly  Ala Gly Val            
    1070                 1075                 1080                        

gat acc  gtg aag tac aac gtg  cac cag cct tcc gag  gaa cgc ctc        3294
Asp Thr  Val Lys Tyr Asn Val  His Gln Pro Ser Glu  Glu Arg Leu            
    1085                 1090                 1095                        

gaa cgc  atg ggc gac acg ggc  atc cat gcc gat ctt  caa aag ggc        3339
Glu Arg  Met Gly Asp Thr Gly  Ile His Ala Asp Leu  Gln Lys Gly            
    1100                 1105                 1110                        

acg gtc  gag aag tgg ccg gcc  ctg aac ctg ttc agc  gtc gac cat        3384
Thr Val  Glu Lys Trp Pro Ala  Leu Asn Leu Phe Ser  Val Asp His            
    1115                 1120                 1125                        

gtc aag  aat atc gag aat ctg  cac ggc tcc agc ctg  aac gac agc        3429
Val Lys  Asn Ile Glu Asn Leu  His Gly Ser Ser Leu  Asn Asp Ser            
    1130                 1135                 1140                        

atc gcc  ggc gac gac cgg gac  aac gag ctc tgg ggc  gac gat ggc        3474
Ile Ala  Gly Asp Asp Arg Asp  Asn Glu Leu Trp Gly  Asp Asp Gly            
    1145                 1150                 1155                        

aac gac  acg ata cac ggc cgg  ggc ggc gac gat atc  ctg cgc ggc        3519
Asn Asp  Thr Ile His Gly Arg  Gly Gly Asp Asp Ile  Leu Arg Gly            
    1160                 1165                 1170                        

ggc ctg  ggc ctg gac acg ctg  tat ggc gag gac ggc  aac gac atc        3564
Gly Leu  Gly Leu Asp Thr Leu  Tyr Gly Glu Asp Gly  Asn Asp Ile            
    1175                 1180                 1185                        

ttc ctg  cag gac gac gag acc  gtc agc gat gac atc  gac ggt ggc        3609
Phe Leu  Gln Asp Asp Glu Thr  Val Ser Asp Asp Ile  Asp Gly Gly            
    1190                 1195                 1200                        

gcg gga  ctg gac acc gtc gac  tat tcc gcc atg atc  cat gca ggc        3654
Ala Gly  Leu Asp Thr Val Asp  Tyr Ser Ala Met Ile  His Ala Gly            
    1205                 1210                 1215                        

aag atc  gtt gcg ccg cat gaa  tac ggc ttc ggg atc  gag gcg gac        3699
Lys Ile  Val Ala Pro His Glu  Tyr Gly Phe Gly Ile  Glu Ala Asp            
    1220                 1225                 1230                        

ctg tcc  gaa ggg tgg gtg cgc  aag gcg gcc cgg cgc  ggc atg gac        3744
Leu Ser  Glu Gly Trp Val Arg  Lys Ala Ala Arg Arg  Gly Met Asp            
    1235                 1240                 1245                        

tac tac  gac agt gtc cgc agt  gtc gaa aac gtc atc  ggc acg agc        3789
Tyr Tyr  Asp Ser Val Arg Ser  Val Glu Asn Val Ile  Gly Thr Ser            
    1250                 1255                 1260                        

atg aag  gat gtg ctc atc ggc  gac gcg caa gcc aat  acc ctg atg        3834
Met Lys  Asp Val Leu Ile Gly  Asp Ala Gln Ala Asn  Thr Leu Met            
    1265                 1270                 1275                        

ggc cag  ggc ggc gac gat acc  gtg cgc ggc ggc gac  ggc gat gat        3879
Gly Gln  Gly Gly Asp Asp Thr  Val Arg Gly Gly Asp  Gly Asp Asp            
    1280                 1285                 1290                        

ctg ctg  ttc ggc ggc gac ggc  aac gac atg ctg tat  gga gac gcc        3924
Leu Leu  Phe Gly Gly Asp Gly  Asn Asp Met Leu Tyr  Gly Asp Ala            
    1295                 1300                 1305                        

ggc aac  gac acc ctc tac gga  ggg ctg ggc gac gat  acc ctt gaa        3969
Gly Asn  Asp Thr Leu Tyr Gly  Gly Leu Gly Asp Asp  Thr Leu Glu            
    1310                 1315                 1320                        

ggc ggc  gcg ggc aac gat tgg  ttc ggc cag acg ccg  gcg cgc gag        4014
Gly Gly  Ala Gly Asn Asp Trp  Phe Gly Gln Thr Pro  Ala Arg Glu            
    1325                 1330                 1335                        

cat gac  gtg ctg cgc ggc ggg  gct ggg gtg gat acc  gtg gat tac        4059
His Asp  Val Leu Arg Gly Gly  Ala Gly Val Asp Thr  Val Asp Tyr            
    1340                 1345                 1350                        

agc cag  gcg ggc gcg cat gcc  ggc gtt gcc acg ggt  cgc atc ggg        4104
Ser Gln  Ala Gly Ala His Ala  Gly Val Ala Thr Gly  Arg Ile Gly            
    1355                 1360                 1365                        

ctg ggt  att ctg gcg gac ctg  ggc gcc ggc cgc gtc  gac aag ctg        4149
Leu Gly  Ile Leu Ala Asp Leu  Gly Ala Gly Arg Val  Asp Lys Leu            
    1370                 1375                 1380                        

ggc gag  gcc ggc agc agc gcc  tac gat acg gtt tcc  ggc atc gaa        4194
Gly Glu  Ala Gly Ser Ser Ala  Tyr Asp Thr Val Ser  Gly Ile Glu            
    1385                 1390                 1395                        

aat gtg  gtg ggc acg gaa ctg  gcc gac cgc atc acg  ggc gat gcg        4239
Asn Val  Val Gly Thr Glu Leu  Ala Asp Arg Ile Thr  Gly Asp Ala            
    1400                 1405                 1410                        

cag gcc  aac gta ctg cgc ggc  gcg ggt ggc gcc gac  gtg ctt gcg        4284
Gln Ala  Asn Val Leu Arg Gly  Ala Gly Gly Ala Asp  Val Leu Ala            
    1415                 1420                 1425                        

ggc ggc  gag ggc gac gat gtg  ctg ctg ggc ggc gac  ggc gac gac        4329
Gly Gly  Glu Gly Asp Asp Val  Leu Leu Gly Gly Asp  Gly Asp Asp            
    1430                 1435                 1440                        

cag ctg  tcg ggc gac gcc gga  cgc gac cgc ttg tac  ggc gaa gcc        4374
Gln Leu  Ser Gly Asp Ala Gly  Arg Asp Arg Leu Tyr  Gly Glu Ala            
    1445                 1450                 1455                        

ggt gac  gac tgg ttc ttc cag  gat gcc gcc aat gcc  ggc aat ctg        4419
Gly Asp  Asp Trp Phe Phe Gln  Asp Ala Ala Asn Ala  Gly Asn Leu            
    1460                 1465                 1470                        

ctc gac  ggt ggt gac ggc aac  gat acc gtg gat ttc  agc ggc ccg        4464
Leu Asp  Gly Gly Asp Gly Asn  Asp Thr Val Asp Phe  Ser Gly Pro            
    1475                 1480                 1485                        

ggc cgg  ggc ctc gac gcc ggc  gca aag ggc gta ttc  ctg agc ctg        4509
Gly Arg  Gly Leu Asp Ala Gly  Ala Lys Gly Val Phe  Leu Ser Leu            
    1490                 1495                 1500                        

ggc aag  ggg ttc gcc agc ctg  atg gac gaa ccc gaa  acc agc aac        4554
Gly Lys  Gly Phe Ala Ser Leu  Met Asp Glu Pro Glu  Thr Ser Asn            
    1505                 1510                 1515                        

gtg ttg  cgc cat atc gag aac  gcc gtg ggc agc gtg  cgt gat gac        4599
Val Leu  Arg His Ile Glu Asn  Ala Val Gly Ser Val  Arg Asp Asp            
    1520                 1525                 1530                        

gtg ctg  atc ggc gac gca ggc  gcc aac gtc ctc aat  ggc ctg gcg        4644
Val Leu  Ile Gly Asp Ala Gly  Ala Asn Val Leu Asn  Gly Leu Ala            
    1535                 1540                 1545                        

ggc aac  gac gtg ctg tcc ggc  ggc gcc ggc gac gat  gtg ctg ctg        4689
Gly Asn  Asp Val Leu Ser Gly  Gly Ala Gly Asp Asp  Val Leu Leu            
    1550                 1555                 1560                        

ggc gac  gag ggc tcg gac ctg  ctc agc ggc gat gcg  ggc aac gac        4734
Gly Asp  Glu Gly Ser Asp Leu  Leu Ser Gly Asp Ala  Gly Asn Asp            
    1565                 1570                 1575                        

gat ctg  ttc ggc ggg cag ggc  gat gat acc tat ctg  ttc ggg gcc        4779
Asp Leu  Phe Gly Gly Gln Gly  Asp Asp Thr Tyr Leu  Phe Gly Ala            
    1580                 1585                 1590                        

ggg tac  gga cat gac acg atc  tac gaa tcg ggc ggc  ggc cat gac        4824
Gly Tyr  Gly His Asp Thr Ile  Tyr Glu Ser Gly Gly  Gly His Asp            
    1595                 1600                 1605                        

acc atc  cgt atc aac gcg ggg  gcg gac cag ctg tgg  ttt gcg cgc        4869
Thr Ile  Arg Ile Asn Ala Gly  Ala Asp Gln Leu Trp  Phe Ala Arg            
    1610                 1615                 1620                        

cag ggc  aac gac ctg gag atc  cgc att ctt ggc acc  gac gat gca        4914
Gln Gly  Asn Asp Leu Glu Ile  Arg Ile Leu Gly Thr  Asp Asp Ala            
    1625                 1630                 1635                        

ctt acc  gtg cac gac tgg tat  cgc gac gcc gat cac  cgg gtg gaa        4959
Leu Thr  Val His Asp Trp Tyr  Arg Asp Ala Asp His  Arg Val Glu            
    1640                 1645                 1650                        

gcc atc  cat gcc gcc aac cag  gcc ata gac ccg gcc  ggc atc gaa        5004
Ala Ile  His Ala Ala Asn Gln  Ala Ile Asp Pro Ala  Gly Ile Glu            
    1655                 1660                 1665                        

aag ctg  gtc gag gca atg gcg  cag tac ccg gac ccc  ggc gcg gcg        5049
Lys Leu  Val Glu Ala Met Ala  Gln Tyr Pro Asp Pro  Gly Ala Ala            
    1670                 1675                 1680                        

gcg gct  gcc ccg ccg gcg gcg  cgc gtg ccg gac acg  ctg atg cag        5094
Ala Ala  Ala Pro Pro Ala Ala  Arg Val Pro Asp Thr  Leu Met Gln            
    1685                 1690                 1695                        

tcc ctg  gct gtc aac tgg cgc  tga                                     5118
Ser Leu  Ala Val Asn Trp Arg                                              
    1700                 1705                                             


<210>  8
<211>  1705
<212>  PRT
<213>  Bordetella bronchiseptica (wild type CyaA)

<400>  8

Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu 
1               5                   10                  15      


Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys 
            20                  25                  30          


Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr 
        35                  40                  45              


Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala 
    50                  55                  60                  


Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro 
65                  70                  75                  80  


Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala 
                85                  90                  95      


Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp 
            100                 105                 110         


Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu 
        115                 120                 125             


Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr 
    130                 135                 140                 


Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala 
145                 150                 155                 160 


Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val 
                165                 170                 175     


Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe 
            180                 185                 190         


Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser 
        195                 200                 205             


Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg 
    210                 215                 220                 


Ala Ala Ser Glu Ala Thr Gly Gly Leu Asp Arg Glu Arg Ile Asp Leu 
225                 230                 235                 240 


Leu Trp Lys Ile Ala Arg Ala Gly Ala Arg Ser Ala Val Gly Thr Glu 
                245                 250                 255     


Ala Arg Arg Gln Phe Arg Tyr Asp Gly Asp Met Asn Ile Gly Val Ile 
            260                 265                 270         


Thr Asp Phe Glu Leu Glu Val Arg Asn Ala Leu Asn Arg Arg Ala His 
        275                 280                 285             


Ala Val Gly Arg Gln Asp Val Val Gln His Gly Thr Glu Gln Asn Asn 
    290                 295                 300                 


Pro Phe Pro Glu Ala Asp Glu Lys Ile Phe Val Val Ser Ala Thr Gly 
305                 310                 315                 320 


Glu Ser Gln Met Leu Thr Arg Gly Gln Leu Lys Glu Tyr Ile Gly Gln 
                325                 330                 335     


Gln Arg Gly Glu Gly Tyr Val Phe Tyr Glu Asn Arg Ala Tyr Gly Val 
            340                 345                 350         


Ala Gly Lys Ser Leu Phe Asp Asp Gly Leu Gly Ala Ala Pro Gly Val 
        355                 360                 365             


Pro Gly Arg Arg Ser Lys Ser Ser Pro Asp Val Leu Glu Thr Val Pro 
    370                 375                 380                 


Ala Ser Pro Gly Leu Arg Arg Pro Ser Leu Gly Ala Val Glu Arg Gln 
385                 390                 395                 400 


Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly Ser Arg Ser Phe Ser 
                405                 410                 415     


Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu Ala Ala Glu Leu Glu 
            420                 425                 430         


Met Thr Arg Gln Val Leu His Ala Gly Ala Arg Gln Asp Asp Ala Glu 
        435                 440                 445             


Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly Gln Arg Ala Leu Gln 
    450                 455                 460                 


Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu Val His Ala Ile Ala 
465                 470                 475                 480 


Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr Asn Thr Pro Gln Glu 
                485                 490                 495     


Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu Gly Glu Ala Ser Ser 
            500                 505                 510         


Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg Gly Ser Ser Arg Trp 
        515                 520                 525             


Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met Ala Leu Gly Gly Gly 
    530                 535                 540                 


Ile Gly Ala Val Gly Ala Gly Met Ser Leu Thr Asp Asp Ala Pro Ala 
545                 550                 555                 560 


Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile Ala Leu Gln Leu Thr Gly 
                565                 570                 575     


Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu Ala Leu Ala Ala Ala 
            580                 585                 590         


Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly Ala Ser Ala Gly Ala 
        595                 600                 605             


Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro Met Glu Ile Tyr Gly 
    610                 615                 620                 


Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu Asp Lys Leu Ala Gln 
625                 630                 635                 640 


Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala Leu Leu Ala Gln Leu 
                645                 650                 655     


Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val Ala Gly Val Ser Ala 
            660                 665                 670         


Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile Ala Ala Ala Ala Ser 
        675                 680                 685             


Val Val Gly Ala Pro Val Ala Val Val Thr Ser Leu Leu Thr Gly Ala 
    690                 695                 700                 


Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro Ile Ile Glu Lys Leu 
705                 710                 715                 720 


Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu Gly Gly Pro Gln Ala 
                725                 730                 735     


Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu Gln Leu Ala Asn Ser 
            740                 745                 750         


Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln Ala Gly Trp Asn Ala 
        755                 760                 765             


Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile Ser Lys Ser Ala Leu 
    770                 775                 780                 


Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn Leu Lys Ser Ala Asp 
785                 790                 795                 800 


Val Phe Val Asp Arg Phe Ile Gln Gly Glu Arg Val Ala Gly Gln Pro 
                805                 810                 815     


Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp Ile Ala Ser Arg Lys 
            820                 825                 830         


Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro Leu Ala Ala Pro Gly 
        835                 840                 845             


Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys Ser Glu Phe Thr Thr 
    850                 855                 860                 


Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp Arg Ile Arg Asp Gly 
865                 870                 875                 880 


Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val Val Ser Gln Leu Val 
                885                 890                 895     


Asp Ala Asn Gly Val Leu Lys His Ser Ile Lys Leu Glu Val Ile Gly 
            900                 905                 910         


Gly Asp Gly Asp Asp Val Val Leu Ala Asn Ala Ser Arg Ile His Tyr 
        915                 920                 925             


Asp Gly Gly Ala Gly Thr Asn Thr Val Ser Tyr Ala Ala Leu Gly Arg 
    930                 935                 940                 


Gln Asp Ser Ile Thr Val Ser Ala Asp Gly Glu Arg Phe Asn Val Arg 
945                 950                 955                 960 


Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg Glu Gly Val Ala Thr Gln 
                965                 970                 975     


Lys Thr Ala Tyr Gly Lys Arg Thr Glu Asn Val Gln Tyr Arg His Val 
            980                 985                 990         


Glu Leu Ala Arg Val Gly Gln Leu  Val Glu Val Asp Thr  Leu Glu His 
        995                 1000                 1005             


Val Gln  His Ile Ile Gly Gly  Ala Gly Asn Asp Ser  Ile Thr Gly 
    1010                 1015                 1020             


Asn Ala  His Asp Asn Phe Leu  Ala Gly Gly Ala Gly  Asp Asp Arg 
    1025                 1030                 1035             


Leu Asp  Gly Gly Ala Gly Asn  Asp Thr Leu Val Gly  Gly Glu Gly 
    1040                 1045                 1050             


His Asn  Thr Val Val Gly Gly  Ala Gly Asp Asp Val  Phe Leu Gln 
    1055                 1060                 1065             


Asp Leu  Gly Val Trp Ser Asn  Gln Leu Asp Gly Gly  Ala Gly Val 
    1070                 1075                 1080             


Asp Thr  Val Lys Tyr Asn Val  His Gln Pro Ser Glu  Glu Arg Leu 
    1085                 1090                 1095             


Glu Arg  Met Gly Asp Thr Gly  Ile His Ala Asp Leu  Gln Lys Gly 
    1100                 1105                 1110             


Thr Val  Glu Lys Trp Pro Ala  Leu Asn Leu Phe Ser  Val Asp His 
    1115                 1120                 1125             


Val Lys  Asn Ile Glu Asn Leu  His Gly Ser Ser Leu  Asn Asp Ser 
    1130                 1135                 1140             


Ile Ala  Gly Asp Asp Arg Asp  Asn Glu Leu Trp Gly  Asp Asp Gly 
    1145                 1150                 1155             


Asn Asp  Thr Ile His Gly Arg  Gly Gly Asp Asp Ile  Leu Arg Gly 
    1160                 1165                 1170             


Gly Leu  Gly Leu Asp Thr Leu  Tyr Gly Glu Asp Gly  Asn Asp Ile 
    1175                 1180                 1185             


Phe Leu  Gln Asp Asp Glu Thr  Val Ser Asp Asp Ile  Asp Gly Gly 
    1190                 1195                 1200             


Ala Gly  Leu Asp Thr Val Asp  Tyr Ser Ala Met Ile  His Ala Gly 
    1205                 1210                 1215             


Lys Ile  Val Ala Pro His Glu  Tyr Gly Phe Gly Ile  Glu Ala Asp 
    1220                 1225                 1230             


Leu Ser  Glu Gly Trp Val Arg  Lys Ala Ala Arg Arg  Gly Met Asp 
    1235                 1240                 1245             


Tyr Tyr  Asp Ser Val Arg Ser  Val Glu Asn Val Ile  Gly Thr Ser 
    1250                 1255                 1260             


Met Lys  Asp Val Leu Ile Gly  Asp Ala Gln Ala Asn  Thr Leu Met 
    1265                 1270                 1275             


Gly Gln  Gly Gly Asp Asp Thr  Val Arg Gly Gly Asp  Gly Asp Asp 
    1280                 1285                 1290             


Leu Leu  Phe Gly Gly Asp Gly  Asn Asp Met Leu Tyr  Gly Asp Ala 
    1295                 1300                 1305             


Gly Asn  Asp Thr Leu Tyr Gly  Gly Leu Gly Asp Asp  Thr Leu Glu 
    1310                 1315                 1320             


Gly Gly  Ala Gly Asn Asp Trp  Phe Gly Gln Thr Pro  Ala Arg Glu 
    1325                 1330                 1335             


His Asp  Val Leu Arg Gly Gly  Ala Gly Val Asp Thr  Val Asp Tyr 
    1340                 1345                 1350             


Ser Gln  Ala Gly Ala His Ala  Gly Val Ala Thr Gly  Arg Ile Gly 
    1355                 1360                 1365             


Leu Gly  Ile Leu Ala Asp Leu  Gly Ala Gly Arg Val  Asp Lys Leu 
    1370                 1375                 1380             


Gly Glu  Ala Gly Ser Ser Ala  Tyr Asp Thr Val Ser  Gly Ile Glu 
    1385                 1390                 1395             


Asn Val  Val Gly Thr Glu Leu  Ala Asp Arg Ile Thr  Gly Asp Ala 
    1400                 1405                 1410             


Gln Ala  Asn Val Leu Arg Gly  Ala Gly Gly Ala Asp  Val Leu Ala 
    1415                 1420                 1425             


Gly Gly  Glu Gly Asp Asp Val  Leu Leu Gly Gly Asp  Gly Asp Asp 
    1430                 1435                 1440             


Gln Leu  Ser Gly Asp Ala Gly  Arg Asp Arg Leu Tyr  Gly Glu Ala 
    1445                 1450                 1455             


Gly Asp  Asp Trp Phe Phe Gln  Asp Ala Ala Asn Ala  Gly Asn Leu 
    1460                 1465                 1470             


Leu Asp  Gly Gly Asp Gly Asn  Asp Thr Val Asp Phe  Ser Gly Pro 
    1475                 1480                 1485             


Gly Arg  Gly Leu Asp Ala Gly  Ala Lys Gly Val Phe  Leu Ser Leu 
    1490                 1495                 1500             


Gly Lys  Gly Phe Ala Ser Leu  Met Asp Glu Pro Glu  Thr Ser Asn 
    1505                 1510                 1515             


Val Leu  Arg His Ile Glu Asn  Ala Val Gly Ser Val  Arg Asp Asp 
    1520                 1525                 1530             


Val Leu  Ile Gly Asp Ala Gly  Ala Asn Val Leu Asn  Gly Leu Ala 
    1535                 1540                 1545             


Gly Asn  Asp Val Leu Ser Gly  Gly Ala Gly Asp Asp  Val Leu Leu 
    1550                 1555                 1560             


Gly Asp  Glu Gly Ser Asp Leu  Leu Ser Gly Asp Ala  Gly Asn Asp 
    1565                 1570                 1575             


Asp Leu  Phe Gly Gly Gln Gly  Asp Asp Thr Tyr Leu  Phe Gly Ala 
    1580                 1585                 1590             


Gly Tyr  Gly His Asp Thr Ile  Tyr Glu Ser Gly Gly  Gly His Asp 
    1595                 1600                 1605             


Thr Ile  Arg Ile Asn Ala Gly  Ala Asp Gln Leu Trp  Phe Ala Arg 
    1610                 1615                 1620             


Gln Gly  Asn Asp Leu Glu Ile  Arg Ile Leu Gly Thr  Asp Asp Ala 
    1625                 1630                 1635             


Leu Thr  Val His Asp Trp Tyr  Arg Asp Ala Asp His  Arg Val Glu 
    1640                 1645                 1650             


Ala Ile  His Ala Ala Asn Gln  Ala Ile Asp Pro Ala  Gly Ile Glu 
    1655                 1660                 1665             


Lys Leu  Val Glu Ala Met Ala  Gln Tyr Pro Asp Pro  Gly Ala Ala 
    1670                 1675                 1680             


Ala Ala  Ala Pro Pro Ala Ala  Arg Val Pro Asp Thr  Leu Met Gln 
    1685                 1690                 1695             


Ser Leu  Ala Val Asn Trp Arg  
    1700                 1705 


<210>  9
<211>  4842
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding polypeptide 1-227 + 321-1706 of SEQ 
       ID NO:2


<220>
<221>  CDS
<222>  (1)..(4842)

<400>  9
atg cag cag tcc cat cag gcc ggt tac gca aac gca gcc gat cgt gaa         48
Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu           
1               5                   10                  15                

tct ggt atc ccg gca gcg gtt ctg gat ggt att aag gca gtt gcc aaa         96
Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys           
            20                  25                  30                    

gag aag aac gct acc ctg atg ttc cgt ctg gtc aac cca cac tct act        144
Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr           
        35                  40                  45                        

tcc ctg atc gcg gaa ggt gtg gcg acc aaa ggc ctg ggt gtg cac gcc        192
Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala           
    50                  55                  60                            

aaa agc agc gac tgg ggt ctg cag gca ggt tat att ccg gtg aac ccg        240
Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro           
65                  70                  75                  80            

aat ctg tct aaa ctg ttc ggt cgt gcc ccg gag gtg atc gca cgt gca        288
Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala           
                85                  90                  95                

gac aac gat gtc aac tct tct ctg gcg cat ggt cac acc gcg gtt gat        336
Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp           
            100                 105                 110                   

ctg acc ctg tcc aaa gaa cgc ctg gat tac ctg cgt cag gcg ggc ctg        384
Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu           
        115                 120                 125                       

gtg acg ggc atg gcc gac ggt gtt gta gcg agc aac cac gcg ggt tat        432
Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr           
    130                 135                 140                           

gaa caa ttt gag ttt cgc gtt aaa gag acc tct gac ggt cgt tac gcg        480
Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala           
145                 150                 155                 160           

gtg cag tac cgc cgc aaa ggt ggc gat gac ttt gaa gct gtc aaa gtg        528
Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val           
                165                 170                 175               

atc ggt aac gct gct gga att ccg ctg acc gcg gat atc gac atg ttt        576
Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe           
            180                 185                 190                   

gcc atc atg cct cac ctg tcc aac ttt cgc gat tcc gca cgc agc tct        624
Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser           
        195                 200                 205                       

gtg acg tct ggt gat tcc gtc act gac tac ctg gct cgt acc cgt cgt        672
Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg           
    210                 215                 220                           

gcg gcc tct gaa tcc cag atg ctg act cgt ggc cag ctg aaa gaa tac        720
Ala Ala Ser Glu Ser Gln Met Leu Thr Arg Gly Gln Leu Lys Glu Tyr           
225                 230                 235                 240           

atc ggc caa cag cgt ggc gaa ggc tac gtt ttc tac gag aat cgt gct        768
Ile Gly Gln Gln Arg Gly Glu Gly Tyr Val Phe Tyr Glu Asn Arg Ala           
                245                 250                 255               

tac ggc gtt gcg ggc aaa tcc ctg ttc gac gat ggt ctg ggc gct gca        816
Tyr Gly Val Ala Gly Lys Ser Leu Phe Asp Asp Gly Leu Gly Ala Ala           
            260                 265                 270                   

ccg ggc gtt ccg agc ggc cgt tct aaa ttc agc ccg gac gta ctg gaa        864
Pro Gly Val Pro Ser Gly Arg Ser Lys Phe Ser Pro Asp Val Leu Glu           
        275                 280                 285                       

act gtg ccg gct tcc ccg ggc ctg cgc cgt ccg tcc ctg ggc gca gtc        912
Thr Val Pro Ala Ser Pro Gly Leu Arg Arg Pro Ser Leu Gly Ala Val           
    290                 295                 300                           

gaa cgt cag gac tcc ggc tac gat tcc ctg gat ggc gtt ggc tcc cgc        960
Glu Arg Gln Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly Ser Arg           
305                 310                 315                 320           

tcc ttc tcc ctg ggc gag gtt tct gac atg gct gcg gtg gaa gcg gca       1008
Ser Phe Ser Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu Ala Ala           
                325                 330                 335               

gag ctg gaa atg acc cgt caa gtg ctg cac gcg ggc gca cgt cag gac       1056
Glu Leu Glu Met Thr Arg Gln Val Leu His Ala Gly Ala Arg Gln Asp           
            340                 345                 350                   

gat gct gag ccg ggc gtg tcc ggt gcg tct gca cac tgg ggt caa cgt       1104
Asp Ala Glu Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly Gln Arg           
        355                 360                 365                       

gcc ctg cag ggt gct caa gct gtc gcg gca gcg cag cgt ctg gta cat       1152
Ala Leu Gln Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu Val His           
    370                 375                 380                           

gcg atc gca ctg atg acc cag ttc ggt cgc gca ggt tct acc aac act       1200
Ala Ile Ala Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr Asn Thr           
385                 390                 395                 400           

cct cag gaa gca gct agc ctg tct gct gct gtt ttc ggt ctg ggc gaa       1248
Pro Gln Glu Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu Gly Glu           
                405                 410                 415               

gcg tct tct gcg gtt gca gaa acc gtg agc ggt ttc ttc cgt ggt tct       1296
Ala Ser Ser Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg Gly Ser           
            420                 425                 430                   

agc cgc tgg gcg ggt ggt ttt ggt gta gca ggt ggc gct atg gcc ctg       1344
Ser Arg Trp Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met Ala Leu           
        435                 440                 445                       

ggt ggc ggt atc gcg gct gct gtc ggc gca ggt atg agc ctg acc gac       1392
Gly Gly Gly Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu Thr Asp           
    450                 455                 460                           

gat gct cct gcg ggc cag aaa gcc gca gct ggc gct gaa atc gcg ctg       1440
Asp Ala Pro Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile Ala Leu           
465                 470                 475                 480           

cag ctg act ggt ggt acc gtt gaa ctg gct agc tct atc gcg ctg gct       1488
Gln Leu Thr Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu Ala           
                485                 490                 495               

ctg gca gcg gca cgt ggc gtg act tct ggc ctg caa gtc gcc ggt gcc       1536
Leu Ala Ala Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly Ala           
            500                 505                 510                   

tct gcg ggc gct gct gcg ggc gct ctg gca gct gca ctg tcc ccc atg       1584
Ser Ala Gly Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro Met           
        515                 520                 525                       

gaa atc tac ggt ctg gta cag cag tct cac tac gca gac cag ctg gat       1632
Glu Ile Tyr Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu Asp           
    530                 535                 540                           

aaa ctg gcg cag gag tct tct gca tac ggt tac gaa ggc gac gca ctg       1680
Lys Leu Ala Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala Leu           
545                 550                 555                 560           

ctg gcg cag ctg tat cgt gac aaa act gct gct gaa ggt gct gtg gca       1728
Leu Ala Gln Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val Ala           
                565                 570                 575               

ggc gtt tct gcg gta ctg tct acc gtt ggc gct gcg gtt tct att gcg       1776
Gly Val Ser Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile Ala           
            580                 585                 590                   

gct gcc gca tcc gtt gta ggt gcg ccg gtt gct gta gtt acc tct ctg       1824
Ala Ala Ala Ser Val Val Gly Ala Pro Val Ala Val Val Thr Ser Leu           
        595                 600                 605                       

ctg act ggt gca ctg aac ggt atc ctg cgt ggt gtt cag cag cct att       1872
Leu Thr Gly Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro Ile           
    610                 615                 620                           

atc gaa aaa ctg gcg aat gat tat gcc cgt aaa atc gac gaa ctg ggc       1920
Ile Glu Lys Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu Gly           
625                 630                 635                 640           

ggt ccg cag gct tat ttt gaa aaa aac ctg cag gcg cgc cac gaa cag       1968
Gly Pro Gln Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu Gln           
                645                 650                 655               

ctg gca aac agc gac ggc ctg cgc aaa atg ctg gca gac ctg caa gct       2016
Leu Ala Asn Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln Ala           
            660                 665                 670                   

ggt tgg aac gcg tct tct gtg atc ggc gtg cag acc acc gaa att agc       2064
Gly Trp Asn Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile Ser           
        675                 680                 685                       

aaa tct gcg ctg gaa ctg gct gca att act ggc aac gcg gat aac ctg       2112
Lys Ser Ala Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn Leu           
    690                 695                 700                           

aaa agc gtt gat gtt ttt gtc gat cgc ttc gtt cag ggc gag cgc gtt       2160
Lys Ser Val Asp Val Phe Val Asp Arg Phe Val Gln Gly Glu Arg Val           
705                 710                 715                 720           

gct ggt cag ccg gtt gtt ctg gac gtt gcg gca ggc ggc atc gac atc       2208
Ala Gly Gln Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp Ile           
                725                 730                 735               

gct agc cgc aag ggc gag cgt ccg gct ctg act ttc att acc ccg ctg       2256
Ala Ser Arg Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro Leu           
            740                 745                 750                   

gca gct ccg ggt gaa gaa cag cgt cgc cgt acc aag act ggt aaa agc       2304
Ala Ala Pro Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys Ser           
        755                 760                 765                       

gag ttc acc acc ttc gtg gaa atc gta ggt aaa cag gac cgc tgg cgt       2352
Glu Phe Thr Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp Arg           
    770                 775                 780                           

att cgc gac ggt gcg gcg gac acc acc atc gac ctg gca aaa gtt gtt       2400
Ile Arg Asp Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val Val           
785                 790                 795                 800           

tcc caa ctg gta gat gct aac ggc gtg ctg aaa cat tct att aaa ctg       2448
Ser Gln Leu Val Asp Ala Asn Gly Val Leu Lys His Ser Ile Lys Leu           
                805                 810                 815               

gat gta atc ggc ggt gac ggc gat gac gtt gta ctg gcg aac gcg tct       2496
Asp Val Ile Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn Ala Ser           
            820                 825                 830                   

cgt atc cac tat gac ggc ggc gca ggt acc aac acg gtt tcc tac gca       2544
Arg Ile His Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser Tyr Ala           
        835                 840                 845                       

gcg ctg ggc cgc cag gat tcc atc act gtt agc gcc gat ggc gaa cgt       2592
Ala Leu Gly Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly Glu Arg           
    850                 855                 860                           

ttc aac gtg cgt aaa cag ctg aat aac gca aac gtc tat cgt gag ggt       2640
Phe Asn Val Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg Glu Gly           
865                 870                 875                 880           

gta gct acc cag acc acc gcg tac ggt aag cgt acc gaa aac gtt cag       2688
Val Ala Thr Gln Thr Thr Ala Tyr Gly Lys Arg Thr Glu Asn Val Gln           
                885                 890                 895               

tat cgt cac gtg gaa ctg gca cgt gtg ggt cag ctg gta gag gtg gat       2736
Tyr Arg His Val Glu Leu Ala Arg Val Gly Gln Leu Val Glu Val Asp           
            900                 905                 910                   

acg ctg gaa cac gtg cag cac atc atc ggt ggc gcc ggt aac gat tcc       2784
Thr Leu Glu His Val Gln His Ile Ile Gly Gly Ala Gly Asn Asp Ser           
        915                 920                 925                       

att act ggt aac gct cac gac aac ttc ctg gca ggt ggt tct ggt gat       2832
Ile Thr Gly Asn Ala His Asp Asn Phe Leu Ala Gly Gly Ser Gly Asp           
    930                 935                 940                           

gat cgt ctg gac ggt ggt gcg ggt aac gat acg ctg gta ggc ggc gaa       2880
Asp Arg Leu Asp Gly Gly Ala Gly Asn Asp Thr Leu Val Gly Gly Glu           
945                 950                 955                 960           

ggt cag aac acc gta att ggt ggt gcc ggt gac gac gtt ttc ctg cag       2928
Gly Gln Asn Thr Val Ile Gly Gly Ala Gly Asp Asp Val Phe Leu Gln           
                965                 970                 975               

gat ctg ggc gtt tgg agc aac cag ctg gat ggc ggt gcc ggt gtt gac       2976
Asp Leu Gly Val Trp Ser Asn Gln Leu Asp Gly Gly Ala Gly Val Asp           
            980                 985                 990                   

acg gtt aag tat aac gtt cac cag  ccg tct gaa gag cgc  ctg gaa cgt     3024
Thr Val Lys Tyr Asn Val His Gln  Pro Ser Glu Glu Arg  Leu Glu Arg         
        995                 1000                 1005                     

atg ggt  gac act ggt att cat  gcc gat ctg cag aaa  ggc act gtt        3069
Met Gly  Asp Thr Gly Ile His  Ala Asp Leu Gln Lys  Gly Thr Val            
    1010                 1015                 1020                        

gaa aaa  tgg cct gcg ctg aac  ctg ttc tct gtg gac  cat gtt aag        3114
Glu Lys  Trp Pro Ala Leu Asn  Leu Phe Ser Val Asp  His Val Lys            
    1025                 1030                 1035                        

aac att  gaa aac ctg cat ggc  tct cgc ctg aac gac  cgt atc gct        3159
Asn Ile  Glu Asn Leu His Gly  Ser Arg Leu Asn Asp  Arg Ile Ala            
    1040                 1045                 1050                        

ggt gac  gac cag gat aac gaa  ctg tgg ggt cat gac  ggc aat gat        3204
Gly Asp  Asp Gln Asp Asn Glu  Leu Trp Gly His Asp  Gly Asn Asp            
    1055                 1060                 1065                        

acc att  cgc ggt cgt ggc ggc  gac gat att ctg cgt  ggc ggt ctg        3249
Thr Ile  Arg Gly Arg Gly Gly  Asp Asp Ile Leu Arg  Gly Gly Leu            
    1070                 1075                 1080                        

ggc ctg  gat acc ctg tat ggt  gaa gat ggt aac gat  att ttc ctg        3294
Gly Leu  Asp Thr Leu Tyr Gly  Glu Asp Gly Asn Asp  Ile Phe Leu            
    1085                 1090                 1095                        

caa gac  gat gaa acg gta tct  gat gac atc gac ggt  ggt gca ggc        3339
Gln Asp  Asp Glu Thr Val Ser  Asp Asp Ile Asp Gly  Gly Ala Gly            
    1100                 1105                 1110                        

ctg gac  acc gta gat tac agc  gct atg atc cat ccg  ggt cgt atc        3384
Leu Asp  Thr Val Asp Tyr Ser  Ala Met Ile His Pro  Gly Arg Ile            
    1115                 1120                 1125                        

gta gct  ccg cac gag tac ggc  ttc ggt atc gag gcg  gac ctg tct        3429
Val Ala  Pro His Glu Tyr Gly  Phe Gly Ile Glu Ala  Asp Leu Ser            
    1130                 1135                 1140                        

cgt gaa  tgg gtt cgt aaa gcg  tcc gcg ctg ggt gtg  gac tac tac        3474
Arg Glu  Trp Val Arg Lys Ala  Ser Ala Leu Gly Val  Asp Tyr Tyr            
    1145                 1150                 1155                        

gat aac  gtt cgt aac gtg gaa  aac gtg atc ggt acc  tcc atg aaa        3519
Asp Asn  Val Arg Asn Val Glu  Asn Val Ile Gly Thr  Ser Met Lys            
    1160                 1165                 1170                        

gac gtg  ctg att ggc gac gca  cag gcc aac act ctg  atg ggc cag        3564
Asp Val  Leu Ile Gly Asp Ala  Gln Ala Asn Thr Leu  Met Gly Gln            
    1175                 1180                 1185                        

ggc ggt  gat gac acg gtt cgc  ggc ggc gac ggt gat  gac ctg ctg        3609
Gly Gly  Asp Asp Thr Val Arg  Gly Gly Asp Gly Asp  Asp Leu Leu            
    1190                 1195                 1200                        

ttc ggt  ggt gac ggc aac gac  atg ctg tac ggc gac  gcg ggc aac        3654
Phe Gly  Gly Asp Gly Asn Asp  Met Leu Tyr Gly Asp  Ala Gly Asn            
    1205                 1210                 1215                        

gac acc  ctg tac ggc ggt ctg  ggt gac gac act ctg  gaa ggt ggt        3699
Asp Thr  Leu Tyr Gly Gly Leu  Gly Asp Asp Thr Leu  Glu Gly Gly            
    1220                 1225                 1230                        

gca ggt  aac gac tgg ttc ggc  caa acc cag gca cgc  gaa cac gac        3744
Ala Gly  Asn Asp Trp Phe Gly  Gln Thr Gln Ala Arg  Glu His Asp            
    1235                 1240                 1245                        

gtg ctg  cgt ggt ggc gac ggc  gta gac acc gtg gat  tac tcc caa        3789
Val Leu  Arg Gly Gly Asp Gly  Val Asp Thr Val Asp  Tyr Ser Gln            
    1250                 1255                 1260                        

act ggc  gct cac gcg ggt atc  gcg gcc ggt cgt atc  ggt ctg ggc        3834
Thr Gly  Ala His Ala Gly Ile  Ala Ala Gly Arg Ile  Gly Leu Gly            
    1265                 1270                 1275                        

att ctg  gcc gat ctg ggt gcc  ggc cgt gtc gac aaa  ctg ggt gag        3879
Ile Leu  Ala Asp Leu Gly Ala  Gly Arg Val Asp Lys  Leu Gly Glu            
    1280                 1285                 1290                        

gct ggc  tct agc gcc tat gat  act gtt tcc ggc atc  gaa aac gtg        3924
Ala Gly  Ser Ser Ala Tyr Asp  Thr Val Ser Gly Ile  Glu Asn Val            
    1295                 1300                 1305                        

gta ggc  act gaa ctg gca gat  cgt atc acg ggt gac  gcg caa gcg        3969
Val Gly  Thr Glu Leu Ala Asp  Arg Ile Thr Gly Asp  Ala Gln Ala            
    1310                 1315                 1320                        

aac gtt  ctg cgt ggt gct ggc  ggt gca gac gtg ctg  gcg ggt ggt        4014
Asn Val  Leu Arg Gly Ala Gly  Gly Ala Asp Val Leu  Ala Gly Gly            
    1325                 1330                 1335                        

gaa ggc  gac gac gta ctg ctg  ggc ggt gac ggt gac  gat cag ctg        4059
Glu Gly  Asp Asp Val Leu Leu  Gly Gly Asp Gly Asp  Asp Gln Leu            
    1340                 1345                 1350                        

agc ggt  gat gcg ggt cgt gac  cgt ctg tac ggt gaa  gca ggt gac        4104
Ser Gly  Asp Ala Gly Arg Asp  Arg Leu Tyr Gly Glu  Ala Gly Asp            
    1355                 1360                 1365                        

gat tgg  ttc ttc cag gac gct  gct aac gct ggc aac  ctg ctg gac        4149
Asp Trp  Phe Phe Gln Asp Ala  Ala Asn Ala Gly Asn  Leu Leu Asp            
    1370                 1375                 1380                        

ggc ggc  gat ggc cgt gac act  gtt gac ttc agc ggt  ccg ggt cgc        4194
Gly Gly  Asp Gly Arg Asp Thr  Val Asp Phe Ser Gly  Pro Gly Arg            
    1385                 1390                 1395                        

ggt ctg  gac gca ggc gcg aaa  ggc gtt ttc ctg agc  ctg ggt aag        4239
Gly Leu  Asp Ala Gly Ala Lys  Gly Val Phe Leu Ser  Leu Gly Lys            
    1400                 1405                 1410                        

ggt ttc  gca tct ctg atg gac  gaa cca gaa acc agc  aat gtc ctg        4284
Gly Phe  Ala Ser Leu Met Asp  Glu Pro Glu Thr Ser  Asn Val Leu            
    1415                 1420                 1425                        

cgt aac  atc gaa aac gct gtc  ggt tcc gca cgc gat  gat gtt ctg        4329
Arg Asn  Ile Glu Asn Ala Val  Gly Ser Ala Arg Asp  Asp Val Leu            
    1430                 1435                 1440                        

att ggc  gat gct ggt gcc aat  gtt ctg aac ggt ctg  gcg ggt aat        4374
Ile Gly  Asp Ala Gly Ala Asn  Val Leu Asn Gly Leu  Ala Gly Asn            
    1445                 1450                 1455                        

gat gta  ctg tct ggt ggc gct  ggt gat gat gtc ctg  ctg ggt gat        4419
Asp Val  Leu Ser Gly Gly Ala  Gly Asp Asp Val Leu  Leu Gly Asp            
    1460                 1465                 1470                        

gag ggc  agc gat ctg ctg tcc  ggc gat gcc ggc aac  gac gat ctg        4464
Glu Gly  Ser Asp Leu Leu Ser  Gly Asp Ala Gly Asn  Asp Asp Leu            
    1475                 1480                 1485                        

ttc ggt  ggc caa ggt gat gat  act tac ctg ttc ggc  gtt ggc tat        4509
Phe Gly  Gly Gln Gly Asp Asp  Thr Tyr Leu Phe Gly  Val Gly Tyr            
    1490                 1495                 1500                        

ggt cat  gac acc atc tat gag  tct ggt ggc ggc cac  gat acg att        4554
Gly His  Asp Thr Ile Tyr Glu  Ser Gly Gly Gly His  Asp Thr Ile            
    1505                 1510                 1515                        

cgt att  aat gca ggt gct gac  caa ctg tgg ttt gca  cgt cag ggt        4599
Arg Ile  Asn Ala Gly Ala Asp  Gln Leu Trp Phe Ala  Arg Gln Gly            
    1520                 1525                 1530                        

aac gat  ctg gaa att cgc atc  ctg ggt act gat gac  gct ctg acc        4644
Asn Asp  Leu Glu Ile Arg Ile  Leu Gly Thr Asp Asp  Ala Leu Thr            
    1535                 1540                 1545                        

gta cac  gac tgg tac cgc gat  gcg gat cac cgc gta  gaa atc atc        4689
Val His  Asp Trp Tyr Arg Asp  Ala Asp His Arg Val  Glu Ile Ile            
    1550                 1555                 1560                        

cat gcg  gct aac caa gct gta  gac cag gct ggt att  gaa aaa ctg        4734
His Ala  Ala Asn Gln Ala Val  Asp Gln Ala Gly Ile  Glu Lys Leu            
    1565                 1570                 1575                        

gta gaa  gcg atg gca cag tat  ccg gac cca ggt gcg  gct gct gca        4779
Val Glu  Ala Met Ala Gln Tyr  Pro Asp Pro Gly Ala  Ala Ala Ala            
    1580                 1585                 1590                        

gca cct  cca gcg gct cgt gtg  ccg gat acc ctg atg  cag agc ctg        4824
Ala Pro  Pro Ala Ala Arg Val  Pro Asp Thr Leu Met  Gln Ser Leu            
    1595                 1600                 1605                        

gcc gtc  aat tgg cgt taa                                              4842
Ala Val  Asn Trp Arg                                                      
    1610                                                                  


<210>  10
<211>  1613
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu 
1               5                   10                  15      


Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys 
            20                  25                  30          


Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr 
        35                  40                  45              


Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala 
    50                  55                  60                  


Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro 
65                  70                  75                  80  


Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala 
                85                  90                  95      


Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp 
            100                 105                 110         


Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu 
        115                 120                 125             


Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr 
    130                 135                 140                 


Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala 
145                 150                 155                 160 


Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val 
                165                 170                 175     


Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe 
            180                 185                 190         


Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser 
        195                 200                 205             


Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg 
    210                 215                 220                 


Ala Ala Ser Glu Ser Gln Met Leu Thr Arg Gly Gln Leu Lys Glu Tyr 
225                 230                 235                 240 


Ile Gly Gln Gln Arg Gly Glu Gly Tyr Val Phe Tyr Glu Asn Arg Ala 
                245                 250                 255     


Tyr Gly Val Ala Gly Lys Ser Leu Phe Asp Asp Gly Leu Gly Ala Ala 
            260                 265                 270         


Pro Gly Val Pro Ser Gly Arg Ser Lys Phe Ser Pro Asp Val Leu Glu 
        275                 280                 285             


Thr Val Pro Ala Ser Pro Gly Leu Arg Arg Pro Ser Leu Gly Ala Val 
    290                 295                 300                 


Glu Arg Gln Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly Ser Arg 
305                 310                 315                 320 


Ser Phe Ser Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu Ala Ala 
                325                 330                 335     


Glu Leu Glu Met Thr Arg Gln Val Leu His Ala Gly Ala Arg Gln Asp 
            340                 345                 350         


Asp Ala Glu Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly Gln Arg 
        355                 360                 365             


Ala Leu Gln Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu Val His 
    370                 375                 380                 


Ala Ile Ala Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr Asn Thr 
385                 390                 395                 400 


Pro Gln Glu Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu Gly Glu 
                405                 410                 415     


Ala Ser Ser Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg Gly Ser 
            420                 425                 430         


Ser Arg Trp Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met Ala Leu 
        435                 440                 445             


Gly Gly Gly Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu Thr Asp 
    450                 455                 460                 


Asp Ala Pro Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile Ala Leu 
465                 470                 475                 480 


Gln Leu Thr Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu Ala 
                485                 490                 495     


Leu Ala Ala Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly Ala 
            500                 505                 510         


Ser Ala Gly Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro Met 
        515                 520                 525             


Glu Ile Tyr Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu Asp 
    530                 535                 540                 


Lys Leu Ala Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala Leu 
545                 550                 555                 560 


Leu Ala Gln Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val Ala 
                565                 570                 575     


Gly Val Ser Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile Ala 
            580                 585                 590         


Ala Ala Ala Ser Val Val Gly Ala Pro Val Ala Val Val Thr Ser Leu 
        595                 600                 605             


Leu Thr Gly Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro Ile 
    610                 615                 620                 


Ile Glu Lys Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu Gly 
625                 630                 635                 640 


Gly Pro Gln Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu Gln 
                645                 650                 655     


Leu Ala Asn Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln Ala 
            660                 665                 670         


Gly Trp Asn Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile Ser 
        675                 680                 685             


Lys Ser Ala Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn Leu 
    690                 695                 700                 


Lys Ser Val Asp Val Phe Val Asp Arg Phe Val Gln Gly Glu Arg Val 
705                 710                 715                 720 


Ala Gly Gln Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp Ile 
                725                 730                 735     


Ala Ser Arg Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro Leu 
            740                 745                 750         


Ala Ala Pro Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys Ser 
        755                 760                 765             


Glu Phe Thr Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp Arg 
    770                 775                 780                 


Ile Arg Asp Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val Val 
785                 790                 795                 800 


Ser Gln Leu Val Asp Ala Asn Gly Val Leu Lys His Ser Ile Lys Leu 
                805                 810                 815     


Asp Val Ile Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn Ala Ser 
            820                 825                 830         


Arg Ile His Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser Tyr Ala 
        835                 840                 845             


Ala Leu Gly Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly Glu Arg 
    850                 855                 860                 


Phe Asn Val Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg Glu Gly 
865                 870                 875                 880 


Val Ala Thr Gln Thr Thr Ala Tyr Gly Lys Arg Thr Glu Asn Val Gln 
                885                 890                 895     


Tyr Arg His Val Glu Leu Ala Arg Val Gly Gln Leu Val Glu Val Asp 
            900                 905                 910         


Thr Leu Glu His Val Gln His Ile Ile Gly Gly Ala Gly Asn Asp Ser 
        915                 920                 925             


Ile Thr Gly Asn Ala His Asp Asn Phe Leu Ala Gly Gly Ser Gly Asp 
    930                 935                 940                 


Asp Arg Leu Asp Gly Gly Ala Gly Asn Asp Thr Leu Val Gly Gly Glu 
945                 950                 955                 960 


Gly Gln Asn Thr Val Ile Gly Gly Ala Gly Asp Asp Val Phe Leu Gln 
                965                 970                 975     


Asp Leu Gly Val Trp Ser Asn Gln Leu Asp Gly Gly Ala Gly Val Asp 
            980                 985                 990         


Thr Val Lys Tyr Asn Val His Gln  Pro Ser Glu Glu Arg  Leu Glu Arg 
        995                 1000                 1005             


Met Gly  Asp Thr Gly Ile His  Ala Asp Leu Gln Lys  Gly Thr Val 
    1010                 1015                 1020             


Glu Lys  Trp Pro Ala Leu Asn  Leu Phe Ser Val Asp  His Val Lys 
    1025                 1030                 1035             


Asn Ile  Glu Asn Leu His Gly  Ser Arg Leu Asn Asp  Arg Ile Ala 
    1040                 1045                 1050             


Gly Asp  Asp Gln Asp Asn Glu  Leu Trp Gly His Asp  Gly Asn Asp 
    1055                 1060                 1065             


Thr Ile  Arg Gly Arg Gly Gly  Asp Asp Ile Leu Arg  Gly Gly Leu 
    1070                 1075                 1080             


Gly Leu  Asp Thr Leu Tyr Gly  Glu Asp Gly Asn Asp  Ile Phe Leu 
    1085                 1090                 1095             


Gln Asp  Asp Glu Thr Val Ser  Asp Asp Ile Asp Gly  Gly Ala Gly 
    1100                 1105                 1110             


Leu Asp  Thr Val Asp Tyr Ser  Ala Met Ile His Pro  Gly Arg Ile 
    1115                 1120                 1125             


Val Ala  Pro His Glu Tyr Gly  Phe Gly Ile Glu Ala  Asp Leu Ser 
    1130                 1135                 1140             


Arg Glu  Trp Val Arg Lys Ala  Ser Ala Leu Gly Val  Asp Tyr Tyr 
    1145                 1150                 1155             


Asp Asn  Val Arg Asn Val Glu  Asn Val Ile Gly Thr  Ser Met Lys 
    1160                 1165                 1170             


Asp Val  Leu Ile Gly Asp Ala  Gln Ala Asn Thr Leu  Met Gly Gln 
    1175                 1180                 1185             


Gly Gly  Asp Asp Thr Val Arg  Gly Gly Asp Gly Asp  Asp Leu Leu 
    1190                 1195                 1200             


Phe Gly  Gly Asp Gly Asn Asp  Met Leu Tyr Gly Asp  Ala Gly Asn 
    1205                 1210                 1215             


Asp Thr  Leu Tyr Gly Gly Leu  Gly Asp Asp Thr Leu  Glu Gly Gly 
    1220                 1225                 1230             


Ala Gly  Asn Asp Trp Phe Gly  Gln Thr Gln Ala Arg  Glu His Asp 
    1235                 1240                 1245             


Val Leu  Arg Gly Gly Asp Gly  Val Asp Thr Val Asp  Tyr Ser Gln 
    1250                 1255                 1260             


Thr Gly  Ala His Ala Gly Ile  Ala Ala Gly Arg Ile  Gly Leu Gly 
    1265                 1270                 1275             


Ile Leu  Ala Asp Leu Gly Ala  Gly Arg Val Asp Lys  Leu Gly Glu 
    1280                 1285                 1290             


Ala Gly  Ser Ser Ala Tyr Asp  Thr Val Ser Gly Ile  Glu Asn Val 
    1295                 1300                 1305             


Val Gly  Thr Glu Leu Ala Asp  Arg Ile Thr Gly Asp  Ala Gln Ala 
    1310                 1315                 1320             


Asn Val  Leu Arg Gly Ala Gly  Gly Ala Asp Val Leu  Ala Gly Gly 
    1325                 1330                 1335             


Glu Gly  Asp Asp Val Leu Leu  Gly Gly Asp Gly Asp  Asp Gln Leu 
    1340                 1345                 1350             


Ser Gly  Asp Ala Gly Arg Asp  Arg Leu Tyr Gly Glu  Ala Gly Asp 
    1355                 1360                 1365             


Asp Trp  Phe Phe Gln Asp Ala  Ala Asn Ala Gly Asn  Leu Leu Asp 
    1370                 1375                 1380             


Gly Gly  Asp Gly Arg Asp Thr  Val Asp Phe Ser Gly  Pro Gly Arg 
    1385                 1390                 1395             


Gly Leu  Asp Ala Gly Ala Lys  Gly Val Phe Leu Ser  Leu Gly Lys 
    1400                 1405                 1410             


Gly Phe  Ala Ser Leu Met Asp  Glu Pro Glu Thr Ser  Asn Val Leu 
    1415                 1420                 1425             


Arg Asn  Ile Glu Asn Ala Val  Gly Ser Ala Arg Asp  Asp Val Leu 
    1430                 1435                 1440             


Ile Gly  Asp Ala Gly Ala Asn  Val Leu Asn Gly Leu  Ala Gly Asn 
    1445                 1450                 1455             


Asp Val  Leu Ser Gly Gly Ala  Gly Asp Asp Val Leu  Leu Gly Asp 
    1460                 1465                 1470             


Glu Gly  Ser Asp Leu Leu Ser  Gly Asp Ala Gly Asn  Asp Asp Leu 
    1475                 1480                 1485             


Phe Gly  Gly Gln Gly Asp Asp  Thr Tyr Leu Phe Gly  Val Gly Tyr 
    1490                 1495                 1500             


Gly His  Asp Thr Ile Tyr Glu  Ser Gly Gly Gly His  Asp Thr Ile 
    1505                 1510                 1515             


Arg Ile  Asn Ala Gly Ala Asp  Gln Leu Trp Phe Ala  Arg Gln Gly 
    1520                 1525                 1530             


Asn Asp  Leu Glu Ile Arg Ile  Leu Gly Thr Asp Asp  Ala Leu Thr 
    1535                 1540                 1545             


Val His  Asp Trp Tyr Arg Asp  Ala Asp His Arg Val  Glu Ile Ile 
    1550                 1555                 1560             


His Ala  Ala Asn Gln Ala Val  Asp Gln Ala Gly Ile  Glu Lys Leu 
    1565                 1570                 1575             


Val Glu  Ala Met Ala Gln Tyr  Pro Asp Pro Gly Ala  Ala Ala Ala 
    1580                 1585                 1590             


Ala Pro  Pro Ala Ala Arg Val  Pro Asp Thr Leu Met  Gln Ser Leu 
    1595                 1600                 1605             


Ala Val  Asn Trp Arg 
    1610             


<210>  11
<211>  4512
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding polypeptide 1-183 + 387-1706 of SEQ 
       ID NO:2


<220>
<221>  CDS
<222>  (1)..(4512)

<400>  11
atg cag cag tcc cat cag gcc ggt tac gca aac gca gcc gat cgt gaa         48
Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu           
1               5                   10                  15                

tct ggt atc ccg gca gcg gtt ctg gat ggt att aag gca gtt gcc aaa         96
Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys           
            20                  25                  30                    

gag aag aac gct acc ctg atg ttc cgt ctg gtc aac cca cac tct act        144
Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr           
        35                  40                  45                        

tcc ctg atc gcg gaa ggt gtg gcg acc aaa ggc ctg ggt gtg cac gcc        192
Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala           
    50                  55                  60                            

aaa agc agc gac tgg ggt ctg cag gca ggt tat att ccg gtg aac ccg        240
Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro           
65                  70                  75                  80            

aat ctg tct aaa ctg ttc ggt cgt gcc ccg gag gtg atc gca cgt gca        288
Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala           
                85                  90                  95                

gac aac gat gtc aac tct tct ctg gcg cat ggt cac acc gcg gtt gat        336
Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp           
            100                 105                 110                   

ctg acc ctg tcc aaa gaa cgc ctg gat tac ctg cgt cag gcg ggc ctg        384
Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu           
        115                 120                 125                       

gtg acg ggc atg gcc gac ggt gtt gta gcg agc aac cac gcg ggt tat        432
Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr           
    130                 135                 140                           

gaa caa ttt gag ttt cgc gtt aaa gag acc tct gac ggt cgt tac gcg        480
Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala           
145                 150                 155                 160           

gtg cag tac cgc cgc aaa ggt ggc gat gac ttt gaa gct gtc aaa gtg        528
Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val           
                165                 170                 175               

atc ggt aac gct gct gga att ccg ggc ctg cgc cgt ccg tcc ctg ggc        576
Ile Gly Asn Ala Ala Gly Ile Pro Gly Leu Arg Arg Pro Ser Leu Gly           
            180                 185                 190                   

gca gtc gaa cgt cag gac tcc ggc tac gat tcc ctg gat ggc gtt ggc        624
Ala Val Glu Arg Gln Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly           
        195                 200                 205                       

tcc cgc tcc ttc tcc ctg ggc gag gtt tct gac atg gct gcg gtg gaa        672
Ser Arg Ser Phe Ser Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu           
    210                 215                 220                           

gcg gca gag ctg gaa atg acc cgt caa gtg ctg cac gcg ggc gca cgt        720
Ala Ala Glu Leu Glu Met Thr Arg Gln Val Leu His Ala Gly Ala Arg           
225                 230                 235                 240           

cag gac gat gct gag ccg ggc gtg tcc ggt gcg tct gca cac tgg ggt        768
Gln Asp Asp Ala Glu Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly           
                245                 250                 255               

caa cgt gcc ctg cag ggt gct caa gct gtc gcg gca gcg cag cgt ctg        816
Gln Arg Ala Leu Gln Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu           
            260                 265                 270                   

gta cat gcg atc gca ctg atg acc cag ttc ggt cgc gca ggt tct acc        864
Val His Ala Ile Ala Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr           
        275                 280                 285                       

aac act cct cag gaa gca gct agc ctg tct gct gct gtt ttc ggt ctg        912
Asn Thr Pro Gln Glu Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu           
    290                 295                 300                           

ggc gaa gcg tct tct gcg gtt gca gaa acc gtg agc ggt ttc ttc cgt        960
Gly Glu Ala Ser Ser Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg           
305                 310                 315                 320           

ggt tct agc cgc tgg gcg ggt ggt ttt ggt gta gca ggt ggc gct atg       1008
Gly Ser Ser Arg Trp Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met           
                325                 330                 335               

gcc ctg ggt ggc ggt atc gcg gct gct gtc ggc gca ggt atg agc ctg       1056
Ala Leu Gly Gly Gly Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu           
            340                 345                 350                   

acc gac gat gct cct gcg ggc cag aaa gcc gca gct ggc gct gaa atc       1104
Thr Asp Asp Ala Pro Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile           
        355                 360                 365                       

gcg ctg cag ctg act ggt ggt acc gtt gaa ctg gct agc tct atc gcg       1152
Ala Leu Gln Leu Thr Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala           
    370                 375                 380                           

ctg gct ctg gca gcg gca cgt ggc gtg act tct ggc ctg caa gtc gcc       1200
Leu Ala Leu Ala Ala Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala           
385                 390                 395                 400           

ggt gcc tct gcg ggc gct gct gcg ggc gct ctg gca gct gca ctg tcc       1248
Gly Ala Ser Ala Gly Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser           
                405                 410                 415               

ccc atg gaa atc tac ggt ctg gta cag cag tct cac tac gca gac cag       1296
Pro Met Glu Ile Tyr Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln           
            420                 425                 430                   

ctg gat aaa ctg gcg cag gag tct tct gca tac ggt tac gaa ggc gac       1344
Leu Asp Lys Leu Ala Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp           
        435                 440                 445                       

gca ctg ctg gcg cag ctg tat cgt gac aaa act gct gct gaa ggt gct       1392
Ala Leu Leu Ala Gln Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala           
    450                 455                 460                           

gtg gca ggc gtt tct gcg gta ctg tct acc gtt ggc gct gcg gtt tct       1440
Val Ala Gly Val Ser Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser           
465                 470                 475                 480           

att gcg gct gcc gca tcc gtt gta ggt gcg ccg gtt gct gta gtt acc       1488
Ile Ala Ala Ala Ala Ser Val Val Gly Ala Pro Val Ala Val Val Thr           
                485                 490                 495               

tct ctg ctg act ggt gca ctg aac ggt atc ctg cgt ggt gtt cag cag       1536
Ser Leu Leu Thr Gly Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln           
            500                 505                 510                   

cct att atc gaa aaa ctg gcg aat gat tat gcc cgt aaa atc gac gaa       1584
Pro Ile Ile Glu Lys Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu           
        515                 520                 525                       

ctg ggc ggt ccg cag gct tat ttt gaa aaa aac ctg cag gcg cgc cac       1632
Leu Gly Gly Pro Gln Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His           
    530                 535                 540                           

gaa cag ctg gca aac agc gac ggc ctg cgc aaa atg ctg gca gac ctg       1680
Glu Gln Leu Ala Asn Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu           
545                 550                 555                 560           

caa gct ggt tgg aac gcg tct tct gtg atc ggc gtg cag acc acc gaa       1728
Gln Ala Gly Trp Asn Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu           
                565                 570                 575               

att agc aaa tct gcg ctg gaa ctg gct gca att act ggc aac gcg gat       1776
Ile Ser Lys Ser Ala Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp           
            580                 585                 590                   

aac ctg aaa agc gtt gat gtt ttt gtc gat cgc ttc gtt cag ggc gag       1824
Asn Leu Lys Ser Val Asp Val Phe Val Asp Arg Phe Val Gln Gly Glu           
        595                 600                 605                       

cgc gtt gct ggt cag ccg gtt gtt ctg gac gtt gcg gca ggc ggc atc       1872
Arg Val Ala Gly Gln Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile           
    610                 615                 620                           

gac atc gct agc cgc aag ggc gag cgt ccg gct ctg act ttc att acc       1920
Asp Ile Ala Ser Arg Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr           
625                 630                 635                 640           

ccg ctg gca gct ccg ggt gaa gaa cag cgt cgc cgt acc aag act ggt       1968
Pro Leu Ala Ala Pro Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly           
                645                 650                 655               

aaa agc gag ttc acc acc ttc gtg gaa atc gta ggt aaa cag gac cgc       2016
Lys Ser Glu Phe Thr Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg           
            660                 665                 670                   

tgg cgt att cgc gac ggt gcg gcg gac acc acc atc gac ctg gca aaa       2064
Trp Arg Ile Arg Asp Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys           
        675                 680                 685                       

gtt gtt tcc caa ctg gta gat gct aac ggc gtg ctg aaa cat tct att       2112
Val Val Ser Gln Leu Val Asp Ala Asn Gly Val Leu Lys His Ser Ile           
    690                 695                 700                           

aaa ctg gat gta atc ggc ggt gac ggc gat gac gtt gta ctg gcg aac       2160
Lys Leu Asp Val Ile Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn           
705                 710                 715                 720           

gcg tct cgt atc cac tat gac ggc ggc gca ggt acc aac acg gtt tcc       2208
Ala Ser Arg Ile His Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser           
                725                 730                 735               

tac gca gcg ctg ggc cgc cag gat tcc atc act gtt agc gcc gat ggc       2256
Tyr Ala Ala Leu Gly Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly           
            740                 745                 750                   

gaa cgt ttc aac gtg cgt aaa cag ctg aat aac gca aac gtc tat cgt       2304
Glu Arg Phe Asn Val Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg           
        755                 760                 765                       

gag ggt gta gct acc cag acc acc gcg tac ggt aag cgt acc gaa aac       2352
Glu Gly Val Ala Thr Gln Thr Thr Ala Tyr Gly Lys Arg Thr Glu Asn           
    770                 775                 780                           

gtt cag tat cgt cac gtg gaa ctg gca cgt gtg ggt cag ctg gta gag       2400
Val Gln Tyr Arg His Val Glu Leu Ala Arg Val Gly Gln Leu Val Glu           
785                 790                 795                 800           

gtg gat acg ctg gaa cac gtg cag cac atc atc ggt ggc gcc ggt aac       2448
Val Asp Thr Leu Glu His Val Gln His Ile Ile Gly Gly Ala Gly Asn           
                805                 810                 815               

gat tcc att act ggt aac gct cac gac aac ttc ctg gca ggt ggt tct       2496
Asp Ser Ile Thr Gly Asn Ala His Asp Asn Phe Leu Ala Gly Gly Ser           
            820                 825                 830                   

ggt gat gat cgt ctg gac ggt ggt gcg ggt aac gat acg ctg gta ggc       2544
Gly Asp Asp Arg Leu Asp Gly Gly Ala Gly Asn Asp Thr Leu Val Gly           
        835                 840                 845                       

ggc gaa ggt cag aac acc gta att ggt ggt gcc ggt gac gac gtt ttc       2592
Gly Glu Gly Gln Asn Thr Val Ile Gly Gly Ala Gly Asp Asp Val Phe           
    850                 855                 860                           

ctg cag gat ctg ggc gtt tgg agc aac cag ctg gat ggc ggt gcc ggt       2640
Leu Gln Asp Leu Gly Val Trp Ser Asn Gln Leu Asp Gly Gly Ala Gly           
865                 870                 875                 880           

gtt gac acg gtt aag tat aac gtt cac cag ccg tct gaa gag cgc ctg       2688
Val Asp Thr Val Lys Tyr Asn Val His Gln Pro Ser Glu Glu Arg Leu           
                885                 890                 895               

gaa cgt atg ggt gac act ggt att cat gcc gat ctg cag aaa ggc act       2736
Glu Arg Met Gly Asp Thr Gly Ile His Ala Asp Leu Gln Lys Gly Thr           
            900                 905                 910                   

gtt gaa aaa tgg cct gcg ctg aac ctg ttc tct gtg gac cat gtt aag       2784
Val Glu Lys Trp Pro Ala Leu Asn Leu Phe Ser Val Asp His Val Lys           
        915                 920                 925                       

aac att gaa aac ctg cat ggc tct cgc ctg aac gac cgt atc gct ggt       2832
Asn Ile Glu Asn Leu His Gly Ser Arg Leu Asn Asp Arg Ile Ala Gly           
    930                 935                 940                           

gac gac cag gat aac gaa ctg tgg ggt cat gac ggc aat gat acc att       2880
Asp Asp Gln Asp Asn Glu Leu Trp Gly His Asp Gly Asn Asp Thr Ile           
945                 950                 955                 960           

cgc ggt cgt ggc ggc gac gat att ctg cgt ggc ggt ctg ggc ctg gat       2928
Arg Gly Arg Gly Gly Asp Asp Ile Leu Arg Gly Gly Leu Gly Leu Asp           
                965                 970                 975               

acc ctg tat ggt gaa gat ggt aac gat att ttc ctg caa gac gat gaa       2976
Thr Leu Tyr Gly Glu Asp Gly Asn Asp Ile Phe Leu Gln Asp Asp Glu           
            980                 985                 990                   

acg gta tct gat gac atc gac ggt  ggt gca ggc ctg gac  acc gta gat     3024
Thr Val Ser Asp Asp Ile Asp Gly  Gly Ala Gly Leu Asp  Thr Val Asp         
        995                 1000                 1005                     

tac agc  gct atg atc cat ccg  ggt cgt atc gta gct  ccg cac gag        3069
Tyr Ser  Ala Met Ile His Pro  Gly Arg Ile Val Ala  Pro His Glu            
    1010                 1015                 1020                        

tac ggc  ttc ggt atc gag gcg  gac ctg tct cgt gaa  tgg gtt cgt        3114
Tyr Gly  Phe Gly Ile Glu Ala  Asp Leu Ser Arg Glu  Trp Val Arg            
    1025                 1030                 1035                        

aaa gcg  tcc gcg ctg ggt gtg  gac tac tac gat aac  gtt cgt aac        3159
Lys Ala  Ser Ala Leu Gly Val  Asp Tyr Tyr Asp Asn  Val Arg Asn            
    1040                 1045                 1050                        

gtg gaa  aac gtg atc ggt acc  tcc atg aaa gac gtg  ctg att ggc        3204
Val Glu  Asn Val Ile Gly Thr  Ser Met Lys Asp Val  Leu Ile Gly            
    1055                 1060                 1065                        

gac gca  cag gcc aac act ctg  atg ggc cag ggc ggt  gat gac acg        3249
Asp Ala  Gln Ala Asn Thr Leu  Met Gly Gln Gly Gly  Asp Asp Thr            
    1070                 1075                 1080                        

gtt cgc  ggc ggc gac ggt gat  gac ctg ctg ttc ggt  ggt gac ggc        3294
Val Arg  Gly Gly Asp Gly Asp  Asp Leu Leu Phe Gly  Gly Asp Gly            
    1085                 1090                 1095                        

aac gac  atg ctg tac ggc gac  gcg ggc aac gac acc  ctg tac ggc        3339
Asn Asp  Met Leu Tyr Gly Asp  Ala Gly Asn Asp Thr  Leu Tyr Gly            
    1100                 1105                 1110                        

ggt ctg  ggt gac gac act ctg  gaa ggt ggt gca ggt  aac gac tgg        3384
Gly Leu  Gly Asp Asp Thr Leu  Glu Gly Gly Ala Gly  Asn Asp Trp            
    1115                 1120                 1125                        

ttc ggc  caa acc cag gca cgc  gaa cac gac gtg ctg  cgt ggt ggc        3429
Phe Gly  Gln Thr Gln Ala Arg  Glu His Asp Val Leu  Arg Gly Gly            
    1130                 1135                 1140                        

gac ggc  gta gac acc gtg gat  tac tcc caa act ggc  gct cac gcg        3474
Asp Gly  Val Asp Thr Val Asp  Tyr Ser Gln Thr Gly  Ala His Ala            
    1145                 1150                 1155                        

ggt atc  gcg gcc ggt cgt atc  ggt ctg ggc att ctg  gcc gat ctg        3519
Gly Ile  Ala Ala Gly Arg Ile  Gly Leu Gly Ile Leu  Ala Asp Leu            
    1160                 1165                 1170                        

ggt gcc  ggc cgt gtc gac aaa  ctg ggt gag gct ggc  tct agc gcc        3564
Gly Ala  Gly Arg Val Asp Lys  Leu Gly Glu Ala Gly  Ser Ser Ala            
    1175                 1180                 1185                        

tat gat  act gtt tcc ggc atc  gaa aac gtg gta ggc  act gaa ctg        3609
Tyr Asp  Thr Val Ser Gly Ile  Glu Asn Val Val Gly  Thr Glu Leu            
    1190                 1195                 1200                        

gca gat  cgt atc acg ggt gac  gcg caa gcg aac gtt  ctg cgt ggt        3654
Ala Asp  Arg Ile Thr Gly Asp  Ala Gln Ala Asn Val  Leu Arg Gly            
    1205                 1210                 1215                        

gct ggc  ggt gca gac gtg ctg  gcg ggt ggt gaa ggc  gac gac gta        3699
Ala Gly  Gly Ala Asp Val Leu  Ala Gly Gly Glu Gly  Asp Asp Val            
    1220                 1225                 1230                        

ctg ctg  ggc ggt gac ggt gac  gat cag ctg agc ggt  gat gcg ggt        3744
Leu Leu  Gly Gly Asp Gly Asp  Asp Gln Leu Ser Gly  Asp Ala Gly            
    1235                 1240                 1245                        

cgt gac  cgt ctg tac ggt gaa  gca ggt gac gat tgg  ttc ttc cag        3789
Arg Asp  Arg Leu Tyr Gly Glu  Ala Gly Asp Asp Trp  Phe Phe Gln            
    1250                 1255                 1260                        

gac gct  gct aac gct ggc aac  ctg ctg gac ggc ggc  gat ggc cgt        3834
Asp Ala  Ala Asn Ala Gly Asn  Leu Leu Asp Gly Gly  Asp Gly Arg            
    1265                 1270                 1275                        

gac act  gtt gac ttc agc ggt  ccg ggt cgc ggt ctg  gac gca ggc        3879
Asp Thr  Val Asp Phe Ser Gly  Pro Gly Arg Gly Leu  Asp Ala Gly            
    1280                 1285                 1290                        

gcg aaa  ggc gtt ttc ctg agc  ctg ggt aag ggt ttc  gca tct ctg        3924
Ala Lys  Gly Val Phe Leu Ser  Leu Gly Lys Gly Phe  Ala Ser Leu            
    1295                 1300                 1305                        

atg gac  gaa cca gaa acc agc  aat gtc ctg cgt aac  atc gaa aac        3969
Met Asp  Glu Pro Glu Thr Ser  Asn Val Leu Arg Asn  Ile Glu Asn            
    1310                 1315                 1320                        

gct gtc  ggt tcc gca cgc gat  gat gtt ctg att ggc  gat gct ggt        4014
Ala Val  Gly Ser Ala Arg Asp  Asp Val Leu Ile Gly  Asp Ala Gly            
    1325                 1330                 1335                        

gcc aat  gtt ctg aac ggt ctg  gcg ggt aat gat gta  ctg tct ggt        4059
Ala Asn  Val Leu Asn Gly Leu  Ala Gly Asn Asp Val  Leu Ser Gly            
    1340                 1345                 1350                        

ggc gct  ggt gat gat gtc ctg  ctg ggt gat gag ggc  agc gat ctg        4104
Gly Ala  Gly Asp Asp Val Leu  Leu Gly Asp Glu Gly  Ser Asp Leu            
    1355                 1360                 1365                        

ctg tcc  ggc gat gcc ggc aac  gac gat ctg ttc ggt  ggc caa ggt        4149
Leu Ser  Gly Asp Ala Gly Asn  Asp Asp Leu Phe Gly  Gly Gln Gly            
    1370                 1375                 1380                        

gat gat  act tac ctg ttc ggc  gtt ggc tat ggt cat  gac acc atc        4194
Asp Asp  Thr Tyr Leu Phe Gly  Val Gly Tyr Gly His  Asp Thr Ile            
    1385                 1390                 1395                        

tat gag  tct ggt ggc ggc cac  gat acg att cgt att  aat gca ggt        4239
Tyr Glu  Ser Gly Gly Gly His  Asp Thr Ile Arg Ile  Asn Ala Gly            
    1400                 1405                 1410                        

gct gac  caa ctg tgg ttt gca  cgt cag ggt aac gat  ctg gaa att        4284
Ala Asp  Gln Leu Trp Phe Ala  Arg Gln Gly Asn Asp  Leu Glu Ile            
    1415                 1420                 1425                        

cgc atc  ctg ggt act gat gac  gct ctg acc gta cac  gac tgg tac        4329
Arg Ile  Leu Gly Thr Asp Asp  Ala Leu Thr Val His  Asp Trp Tyr            
    1430                 1435                 1440                        

cgc gat  gcg gat cac cgc gta  gaa atc atc cat gcg  gct aac caa        4374
Arg Asp  Ala Asp His Arg Val  Glu Ile Ile His Ala  Ala Asn Gln            
    1445                 1450                 1455                        

gct gta  gac cag gct ggt att  gaa aaa ctg gta gaa  gcg atg gca        4419
Ala Val  Asp Gln Ala Gly Ile  Glu Lys Leu Val Glu  Ala Met Ala            
    1460                 1465                 1470                        

cag tat  ccg gac cca ggt gcg  gct gct gca gca cct  cca gcg gct        4464
Gln Tyr  Pro Asp Pro Gly Ala  Ala Ala Ala Ala Pro  Pro Ala Ala            
    1475                 1480                 1485                        

cgt gtg  ccg gat acc ctg atg  cag agc ctg gcc gtc  aat tgg cgt        4509
Arg Val  Pro Asp Thr Leu Met  Gln Ser Leu Ala Val  Asn Trp Arg            
    1490                 1495                 1500                        

taa                                                                   4512


<210>  12
<211>  1503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu 
1               5                   10                  15      


Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys 
            20                  25                  30          


Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr 
        35                  40                  45              


Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala 
    50                  55                  60                  


Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro 
65                  70                  75                  80  


Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala 
                85                  90                  95      


Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp 
            100                 105                 110         


Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu 
        115                 120                 125             


Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr 
    130                 135                 140                 


Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala 
145                 150                 155                 160 


Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val 
                165                 170                 175     


Ile Gly Asn Ala Ala Gly Ile Pro Gly Leu Arg Arg Pro Ser Leu Gly 
            180                 185                 190         


Ala Val Glu Arg Gln Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly 
        195                 200                 205             


Ser Arg Ser Phe Ser Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu 
    210                 215                 220                 


Ala Ala Glu Leu Glu Met Thr Arg Gln Val Leu His Ala Gly Ala Arg 
225                 230                 235                 240 


Gln Asp Asp Ala Glu Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly 
                245                 250                 255     


Gln Arg Ala Leu Gln Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu 
            260                 265                 270         


Val His Ala Ile Ala Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr 
        275                 280                 285             


Asn Thr Pro Gln Glu Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu 
    290                 295                 300                 


Gly Glu Ala Ser Ser Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg 
305                 310                 315                 320 


Gly Ser Ser Arg Trp Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met 
                325                 330                 335     


Ala Leu Gly Gly Gly Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu 
            340                 345                 350         


Thr Asp Asp Ala Pro Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile 
        355                 360                 365             


Ala Leu Gln Leu Thr Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala 
    370                 375                 380                 


Leu Ala Leu Ala Ala Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala 
385                 390                 395                 400 


Gly Ala Ser Ala Gly Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser 
                405                 410                 415     


Pro Met Glu Ile Tyr Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln 
            420                 425                 430         


Leu Asp Lys Leu Ala Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp 
        435                 440                 445             


Ala Leu Leu Ala Gln Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala 
    450                 455                 460                 


Val Ala Gly Val Ser Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser 
465                 470                 475                 480 


Ile Ala Ala Ala Ala Ser Val Val Gly Ala Pro Val Ala Val Val Thr 
                485                 490                 495     


Ser Leu Leu Thr Gly Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln 
            500                 505                 510         


Pro Ile Ile Glu Lys Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu 
        515                 520                 525             


Leu Gly Gly Pro Gln Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His 
    530                 535                 540                 


Glu Gln Leu Ala Asn Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu 
545                 550                 555                 560 


Gln Ala Gly Trp Asn Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu 
                565                 570                 575     


Ile Ser Lys Ser Ala Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp 
            580                 585                 590         


Asn Leu Lys Ser Val Asp Val Phe Val Asp Arg Phe Val Gln Gly Glu 
        595                 600                 605             


Arg Val Ala Gly Gln Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile 
    610                 615                 620                 


Asp Ile Ala Ser Arg Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr 
625                 630                 635                 640 


Pro Leu Ala Ala Pro Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly 
                645                 650                 655     


Lys Ser Glu Phe Thr Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg 
            660                 665                 670         


Trp Arg Ile Arg Asp Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys 
        675                 680                 685             


Val Val Ser Gln Leu Val Asp Ala Asn Gly Val Leu Lys His Ser Ile 
    690                 695                 700                 


Lys Leu Asp Val Ile Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn 
705                 710                 715                 720 


Ala Ser Arg Ile His Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser 
                725                 730                 735     


Tyr Ala Ala Leu Gly Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly 
            740                 745                 750         


Glu Arg Phe Asn Val Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg 
        755                 760                 765             


Glu Gly Val Ala Thr Gln Thr Thr Ala Tyr Gly Lys Arg Thr Glu Asn 
    770                 775                 780                 


Val Gln Tyr Arg His Val Glu Leu Ala Arg Val Gly Gln Leu Val Glu 
785                 790                 795                 800 


Val Asp Thr Leu Glu His Val Gln His Ile Ile Gly Gly Ala Gly Asn 
                805                 810                 815     


Asp Ser Ile Thr Gly Asn Ala His Asp Asn Phe Leu Ala Gly Gly Ser 
            820                 825                 830         


Gly Asp Asp Arg Leu Asp Gly Gly Ala Gly Asn Asp Thr Leu Val Gly 
        835                 840                 845             


Gly Glu Gly Gln Asn Thr Val Ile Gly Gly Ala Gly Asp Asp Val Phe 
    850                 855                 860                 


Leu Gln Asp Leu Gly Val Trp Ser Asn Gln Leu Asp Gly Gly Ala Gly 
865                 870                 875                 880 


Val Asp Thr Val Lys Tyr Asn Val His Gln Pro Ser Glu Glu Arg Leu 
                885                 890                 895     


Glu Arg Met Gly Asp Thr Gly Ile His Ala Asp Leu Gln Lys Gly Thr 
            900                 905                 910         


Val Glu Lys Trp Pro Ala Leu Asn Leu Phe Ser Val Asp His Val Lys 
        915                 920                 925             


Asn Ile Glu Asn Leu His Gly Ser Arg Leu Asn Asp Arg Ile Ala Gly 
    930                 935                 940                 


Asp Asp Gln Asp Asn Glu Leu Trp Gly His Asp Gly Asn Asp Thr Ile 
945                 950                 955                 960 


Arg Gly Arg Gly Gly Asp Asp Ile Leu Arg Gly Gly Leu Gly Leu Asp 
                965                 970                 975     


Thr Leu Tyr Gly Glu Asp Gly Asn Asp Ile Phe Leu Gln Asp Asp Glu 
            980                 985                 990         


Thr Val Ser Asp Asp Ile Asp Gly  Gly Ala Gly Leu Asp  Thr Val Asp 
        995                 1000                 1005             


Tyr Ser  Ala Met Ile His Pro  Gly Arg Ile Val Ala  Pro His Glu 
    1010                 1015                 1020             


Tyr Gly  Phe Gly Ile Glu Ala  Asp Leu Ser Arg Glu  Trp Val Arg 
    1025                 1030                 1035             


Lys Ala  Ser Ala Leu Gly Val  Asp Tyr Tyr Asp Asn  Val Arg Asn 
    1040                 1045                 1050             


Val Glu  Asn Val Ile Gly Thr  Ser Met Lys Asp Val  Leu Ile Gly 
    1055                 1060                 1065             


Asp Ala  Gln Ala Asn Thr Leu  Met Gly Gln Gly Gly  Asp Asp Thr 
    1070                 1075                 1080             


Val Arg  Gly Gly Asp Gly Asp  Asp Leu Leu Phe Gly  Gly Asp Gly 
    1085                 1090                 1095             


Asn Asp  Met Leu Tyr Gly Asp  Ala Gly Asn Asp Thr  Leu Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Gly Asp Asp Thr Leu  Glu Gly Gly Ala Gly  Asn Asp Trp 
    1115                 1120                 1125             


Phe Gly  Gln Thr Gln Ala Arg  Glu His Asp Val Leu  Arg Gly Gly 
    1130                 1135                 1140             


Asp Gly  Val Asp Thr Val Asp  Tyr Ser Gln Thr Gly  Ala His Ala 
    1145                 1150                 1155             


Gly Ile  Ala Ala Gly Arg Ile  Gly Leu Gly Ile Leu  Ala Asp Leu 
    1160                 1165                 1170             


Gly Ala  Gly Arg Val Asp Lys  Leu Gly Glu Ala Gly  Ser Ser Ala 
    1175                 1180                 1185             


Tyr Asp  Thr Val Ser Gly Ile  Glu Asn Val Val Gly  Thr Glu Leu 
    1190                 1195                 1200             


Ala Asp  Arg Ile Thr Gly Asp  Ala Gln Ala Asn Val  Leu Arg Gly 
    1205                 1210                 1215             


Ala Gly  Gly Ala Asp Val Leu  Ala Gly Gly Glu Gly  Asp Asp Val 
    1220                 1225                 1230             


Leu Leu  Gly Gly Asp Gly Asp  Asp Gln Leu Ser Gly  Asp Ala Gly 
    1235                 1240                 1245             


Arg Asp  Arg Leu Tyr Gly Glu  Ala Gly Asp Asp Trp  Phe Phe Gln 
    1250                 1255                 1260             


Asp Ala  Ala Asn Ala Gly Asn  Leu Leu Asp Gly Gly  Asp Gly Arg 
    1265                 1270                 1275             


Asp Thr  Val Asp Phe Ser Gly  Pro Gly Arg Gly Leu  Asp Ala Gly 
    1280                 1285                 1290             


Ala Lys  Gly Val Phe Leu Ser  Leu Gly Lys Gly Phe  Ala Ser Leu 
    1295                 1300                 1305             


Met Asp  Glu Pro Glu Thr Ser  Asn Val Leu Arg Asn  Ile Glu Asn 
    1310                 1315                 1320             


Ala Val  Gly Ser Ala Arg Asp  Asp Val Leu Ile Gly  Asp Ala Gly 
    1325                 1330                 1335             


Ala Asn  Val Leu Asn Gly Leu  Ala Gly Asn Asp Val  Leu Ser Gly 
    1340                 1345                 1350             


Gly Ala  Gly Asp Asp Val Leu  Leu Gly Asp Glu Gly  Ser Asp Leu 
    1355                 1360                 1365             


Leu Ser  Gly Asp Ala Gly Asn  Asp Asp Leu Phe Gly  Gly Gln Gly 
    1370                 1375                 1380             


Asp Asp  Thr Tyr Leu Phe Gly  Val Gly Tyr Gly His  Asp Thr Ile 
    1385                 1390                 1395             


Tyr Glu  Ser Gly Gly Gly His  Asp Thr Ile Arg Ile  Asn Ala Gly 
    1400                 1405                 1410             


Ala Asp  Gln Leu Trp Phe Ala  Arg Gln Gly Asn Asp  Leu Glu Ile 
    1415                 1420                 1425             


Arg Ile  Leu Gly Thr Asp Asp  Ala Leu Thr Val His  Asp Trp Tyr 
    1430                 1435                 1440             


Arg Asp  Ala Asp His Arg Val  Glu Ile Ile His Ala  Ala Asn Gln 
    1445                 1450                 1455             


Ala Val  Asp Gln Ala Gly Ile  Glu Lys Leu Val Glu  Ala Met Ala 
    1460                 1465                 1470             


Gln Tyr  Pro Asp Pro Gly Ala  Ala Ala Ala Ala Pro  Pro Ala Ala 
    1475                 1480                 1485             


Arg Val  Pro Asp Thr Leu Met  Gln Ser Leu Ala Val  Asn Trp Arg 
    1490                 1495                 1500             


<210>  13
<211>  1613
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide 1-227 + 321-1706 of SEQ ID NO: 4

<400>  13

Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu 
1               5                   10                  15      


Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys 
            20                  25                  30          


Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr 
        35                  40                  45              


Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala 
    50                  55                  60                  


Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro 
65                  70                  75                  80  


Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala 
                85                  90                  95      


Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp 
            100                 105                 110         


Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu 
        115                 120                 125             


Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr 
    130                 135                 140                 


Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala 
145                 150                 155                 160 


Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val 
                165                 170                 175     


Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe 
            180                 185                 190         


Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser 
        195                 200                 205             


Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg 
    210                 215                 220                 


Ala Ala Ser Glu Ser Gln Met Leu Thr Arg Gly Gln Leu Lys Glu Tyr 
225                 230                 235                 240 


Ile Gly Gln Gln Arg Gly Glu Gly Tyr Val Phe Tyr Glu Asn Arg Ala 
                245                 250                 255     


Tyr Gly Val Ala Gly Lys Ser Leu Phe Asp Asp Gly Leu Gly Ala Ala 
            260                 265                 270         


Pro Gly Val Pro Ser Gly Arg Ser Lys Phe Ser Pro Asp Val Leu Glu 
        275                 280                 285             


Thr Val Pro Ala Ser Pro Gly Leu Arg Arg Pro Ser Leu Gly Ala Val 
    290                 295                 300                 


Glu Arg Gln Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly Ser Arg 
305                 310                 315                 320 


Ser Phe Ser Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu Ala Ala 
                325                 330                 335     


Glu Leu Glu Met Thr Arg Gln Val Leu His Ala Gly Ala Arg Gln Asp 
            340                 345                 350         


Asp Ala Glu Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly Gln Arg 
        355                 360                 365             


Ala Leu Gln Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu Val His 
    370                 375                 380                 


Ala Ile Ala Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr Asn Thr 
385                 390                 395                 400 


Pro Gln Glu Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu Gly Glu 
                405                 410                 415     


Ala Ser Ser Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg Gly Ser 
            420                 425                 430         


Ser Arg Trp Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met Ala Leu 
        435                 440                 445             


Gly Gly Gly Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu Thr Asp 
    450                 455                 460                 


Asp Ala Pro Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile Ala Leu 
465                 470                 475                 480 


Gln Leu Thr Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu Ala 
                485                 490                 495     


Leu Ala Ala Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly Ala 
            500                 505                 510         


Ser Ala Gly Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro Met 
        515                 520                 525             


Glu Ile Tyr Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu Asp 
    530                 535                 540                 


Lys Leu Ala Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala Leu 
545                 550                 555                 560 


Leu Ala Gln Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val Ala 
                565                 570                 575     


Gly Val Ser Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile Ala 
            580                 585                 590         


Ala Ala Ala Ser Val Val Gly Ala Pro Val Ala Val Val Thr Ser Leu 
        595                 600                 605             


Leu Thr Gly Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro Ile 
    610                 615                 620                 


Ile Glu Lys Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu Gly 
625                 630                 635                 640 


Gly Pro Gln Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu Gln 
                645                 650                 655     


Leu Ala Asn Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln Ala 
            660                 665                 670         


Gly Trp Asn Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile Ser 
        675                 680                 685             


Lys Ser Ala Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn Leu 
    690                 695                 700                 


Lys Ser Val Asp Val Phe Val Asp Arg Phe Val Gln Gly Glu Arg Val 
705                 710                 715                 720 


Ala Gly Gln Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp Ile 
                725                 730                 735     


Ala Ser Arg Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro Leu 
            740                 745                 750         


Ala Ala Pro Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys Ser 
        755                 760                 765             


Glu Phe Thr Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp Arg 
    770                 775                 780                 


Ile Arg Asp Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val Val 
785                 790                 795                 800 


Ser Gln Leu Val Asp Ala Asn Gly Val Leu Lys His Ser Ile Lys Leu 
                805                 810                 815     


Asp Val Ile Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn Ala Ser 
            820                 825                 830         


Arg Ile His Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser Tyr Ala 
        835                 840                 845             


Ala Leu Gly Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly Glu Arg 
    850                 855                 860                 


Phe Asn Val Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg Glu Gly 
865                 870                 875                 880 


Val Ala Thr Gln Thr Thr Ala Tyr Gly Lys Arg Thr Glu Asn Val Gln 
                885                 890                 895     


Tyr Arg His Val Glu Leu Ala Arg Val Gly Gln Leu Val Glu Val Asp 
            900                 905                 910         


Thr Leu Glu His Val Gln His Ile Ile Gly Gly Ala Gly Asn Asp Ser 
        915                 920                 925             


Ile Thr Gly Asn Ala His Asp Asn Phe Leu Ala Gly Gly Ser Gly Asp 
    930                 935                 940                 


Asp Arg Leu Asp Gly Gly Ala Gly Asn Asp Thr Leu Val Gly Gly Glu 
945                 950                 955                 960 


Gly Gln Asn Thr Val Ile Gly Gly Ala Gly Asp Asp Val Phe Leu Gln 
                965                 970                 975     


Asp Leu Gly Val Trp Ser Asn Gln Leu Asp Gly Gly Ala Gly Val Asp 
            980                 985                 990         


Thr Val Lys Tyr Asn Val His Gln  Pro Ser Glu Glu Arg  Leu Glu Arg 
        995                 1000                 1005             


Met Gly  Asp Thr Gly Ile His  Ala Asp Leu Gln Lys  Gly Thr Val 
    1010                 1015                 1020             


Glu Lys  Trp Pro Ala Leu Asn  Leu Phe Ser Val Asp  His Val Lys 
    1025                 1030                 1035             


Asn Ile  Glu Asn Leu His Gly  Ser Arg Leu Asn Asp  Arg Ile Ala 
    1040                 1045                 1050             


Gly Asp  Asp Gln Asp Asn Glu  Leu Trp Gly His Asp  Gly Asn Asp 
    1055                 1060                 1065             


Thr Ile  Arg Gly Arg Gly Gly  Asp Asp Ile Leu Arg  Gly Gly Leu 
    1070                 1075                 1080             


Gly Leu  Asp Thr Leu Tyr Gly  Glu Asp Gly Asn Asp  Ile Phe Leu 
    1085                 1090                 1095             


Gln Asp  Asp Glu Thr Val Ser  Asp Asp Ile Asp Gly  Gly Ala Gly 
    1100                 1105                 1110             


Leu Asp  Thr Val Asp Tyr Ser  Ala Met Ile His Pro  Gly Arg Ile 
    1115                 1120                 1125             


Val Ala  Pro His Glu Tyr Gly  Phe Gly Ile Glu Ala  Asp Leu Ser 
    1130                 1135                 1140             


Arg Glu  Trp Val Arg Lys Ala  Ser Ala Leu Gly Val  Asp Tyr Tyr 
    1145                 1150                 1155             


Asp Asn  Val Arg Asn Val Glu  Asn Val Ile Gly Thr  Ser Met Lys 
    1160                 1165                 1170             


Asp Val  Leu Ile Gly Asp Ala  Gln Ala Asn Thr Leu  Met Gly Gln 
    1175                 1180                 1185             


Gly Gly  Asp Asp Thr Val Arg  Gly Gly Asp Gly Asp  Asp Leu Leu 
    1190                 1195                 1200             


Phe Gly  Gly Asp Gly Asn Asp  Met Leu Tyr Gly Asp  Ala Gly Asn 
    1205                 1210                 1215             


Asp Thr  Leu Tyr Gly Gly Leu  Gly Asp Asp Thr Leu  Glu Gly Gly 
    1220                 1225                 1230             


Ala Gly  Asn Asp Trp Phe Gly  Gln Thr Gln Ala Arg  Glu His Asp 
    1235                 1240                 1245             


Val Leu  Arg Gly Gly Asp Gly  Val Asp Thr Val Asp  Tyr Ser Gln 
    1250                 1255                 1260             


Thr Gly  Ala His Ala Gly Ile  Ala Ala Gly Arg Ile  Gly Leu Gly 
    1265                 1270                 1275             


Ile Leu  Ala Asp Leu Gly Ala  Gly Arg Val Asp Lys  Leu Gly Glu 
    1280                 1285                 1290             


Ala Gly  Ser Ser Ala Tyr Asp  Thr Val Ser Gly Ile  Glu Asn Val 
    1295                 1300                 1305             


Val Gly  Thr Glu Leu Ala Asp  Arg Ile Thr Gly Asp  Ala Gln Ala 
    1310                 1315                 1320             


Asn Val  Leu Arg Gly Ala Gly  Gly Ala Asp Val Leu  Ala Gly Gly 
    1325                 1330                 1335             


Glu Gly  Asp Asp Val Leu Leu  Gly Gly Asp Gly Asp  Asp Gln Leu 
    1340                 1345                 1350             


Ser Gly  Asp Ala Gly Arg Asp  Arg Leu Tyr Gly Glu  Ala Gly Asp 
    1355                 1360                 1365             


Asp Trp  Phe Phe Gln Asp Ala  Ala Asn Ala Gly Asn  Leu Leu Asp 
    1370                 1375                 1380             


Gly Gly  Asp Gly Arg Asp Thr  Val Asp Phe Ser Gly  Pro Gly Arg 
    1385                 1390                 1395             


Gly Leu  Asp Ala Gly Ala Lys  Gly Val Phe Leu Ser  Leu Gly Lys 
    1400                 1405                 1410             


Gly Phe  Ala Ser Leu Met Asp  Glu Pro Glu Thr Ser  Asn Val Leu 
    1415                 1420                 1425             


Arg Asn  Ile Glu Asn Ala Val  Gly Ser Ala Arg Asp  Asp Val Leu 
    1430                 1435                 1440             


Ile Gly  Asp Ala Gly Ala Asn  Val Leu Asn Gly Leu  Ala Gly Asn 
    1445                 1450                 1455             


Asp Val  Leu Ser Gly Gly Ala  Gly Asp Asp Val Leu  Leu Gly Asp 
    1460                 1465                 1470             


Glu Gly  Ser Asp Leu Leu Ser  Gly Asp Ala Gly Asn  Asp Asp Leu 
    1475                 1480                 1485             


Phe Gly  Gly Gln Gly Asp Asp  Thr Tyr Leu Phe Gly  Val Gly Tyr 
    1490                 1495                 1500             


Gly His  Asp Thr Ile Tyr Glu  Ser Gly Gly Gly His  Asp Thr Ile 
    1505                 1510                 1515             


Arg Ile  Asn Ala Gly Ala Asp  Gln Leu Trp Phe Ala  Arg Gln Gly 
    1520                 1525                 1530             


Asn Asp  Leu Glu Ile Arg Ile  Leu Gly Thr Asp Asp  Ala Leu Thr 
    1535                 1540                 1545             


Val His  Asp Trp Tyr Arg Asp  Ala Asp His Arg Val  Glu Ile Ile 
    1550                 1555                 1560             


His Ala  Ala Asn Gln Ala Val  Asp Gln Ala Gly Ile  Glu Lys Leu 
    1565                 1570                 1575             


Val Glu  Ala Met Ala Gln Tyr  Pro Asp Pro Gly Ala  Ala Ala Ala 
    1580                 1585                 1590             


Ala Pro  Pro Ala Ala Arg Val  Pro Asp Thr Leu Met  Gln Ser Leu 
    1595                 1600                 1605             


Ala Val  Asn Trp Arg 
    1610             


<210>  14
<211>  1503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide 1-183 + 387-1706 of SEQ ID NO:4

<400>  14

Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu 
1               5                   10                  15      


Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys 
            20                  25                  30          


Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr 
        35                  40                  45              


Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala 
    50                  55                  60                  


Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro 
65                  70                  75                  80  


Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala 
                85                  90                  95      


Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp 
            100                 105                 110         


Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu 
        115                 120                 125             


Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr 
    130                 135                 140                 


Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala 
145                 150                 155                 160 


Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val 
                165                 170                 175     


Ile Gly Asn Ala Ala Gly Ile Pro Gly Leu Arg Arg Pro Ser Leu Gly 
            180                 185                 190         


Ala Val Glu Arg Gln Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly 
        195                 200                 205             


Ser Arg Ser Phe Ser Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu 
    210                 215                 220                 


Ala Ala Glu Leu Glu Met Thr Arg Gln Val Leu His Ala Gly Ala Arg 
225                 230                 235                 240 


Gln Asp Asp Ala Glu Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly 
                245                 250                 255     


Gln Arg Ala Leu Gln Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu 
            260                 265                 270         


Val His Ala Ile Ala Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr 
        275                 280                 285             


Asn Thr Pro Gln Glu Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu 
    290                 295                 300                 


Gly Glu Ala Ser Ser Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg 
305                 310                 315                 320 


Gly Ser Ser Arg Trp Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met 
                325                 330                 335     


Ala Leu Gly Gly Gly Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu 
            340                 345                 350         


Thr Asp Asp Ala Pro Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile 
        355                 360                 365             


Ala Leu Gln Leu Thr Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala 
    370                 375                 380                 


Leu Ala Leu Ala Ala Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala 
385                 390                 395                 400 


Gly Ala Ser Ala Gly Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser 
                405                 410                 415     


Pro Met Glu Ile Tyr Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln 
            420                 425                 430         


Leu Asp Lys Leu Ala Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp 
        435                 440                 445             


Ala Leu Leu Ala Gln Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala 
    450                 455                 460                 


Val Ala Gly Val Ser Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser 
465                 470                 475                 480 


Ile Ala Ala Ala Ala Ser Val Val Gly Ala Pro Val Ala Val Val Thr 
                485                 490                 495     


Ser Leu Leu Thr Gly Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln 
            500                 505                 510         


Pro Ile Ile Glu Lys Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu 
        515                 520                 525             


Leu Gly Gly Pro Gln Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His 
    530                 535                 540                 


Glu Gln Leu Ala Asn Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu 
545                 550                 555                 560 


Gln Ala Gly Trp Asn Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu 
                565                 570                 575     


Ile Ser Lys Ser Ala Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp 
            580                 585                 590         


Asn Leu Lys Ser Val Asp Val Phe Val Asp Arg Phe Val Gln Gly Glu 
        595                 600                 605             


Arg Val Ala Gly Gln Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile 
    610                 615                 620                 


Asp Ile Ala Ser Arg Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr 
625                 630                 635                 640 


Pro Leu Ala Ala Pro Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly 
                645                 650                 655     


Lys Ser Glu Phe Thr Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg 
            660                 665                 670         


Trp Arg Ile Arg Asp Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys 
        675                 680                 685             


Val Val Ser Gln Leu Val Asp Ala Asn Gly Val Leu Lys His Ser Ile 
    690                 695                 700                 


Lys Leu Asp Val Ile Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn 
705                 710                 715                 720 


Ala Ser Arg Ile His Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser 
                725                 730                 735     


Tyr Ala Ala Leu Gly Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly 
            740                 745                 750         


Glu Arg Phe Asn Val Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg 
        755                 760                 765             


Glu Gly Val Ala Thr Gln Thr Thr Ala Tyr Gly Lys Arg Thr Glu Asn 
    770                 775                 780                 


Val Gln Tyr Arg His Val Glu Leu Ala Arg Val Gly Gln Leu Val Glu 
785                 790                 795                 800 


Val Asp Thr Leu Glu His Val Gln His Ile Ile Gly Gly Ala Gly Asn 
                805                 810                 815     


Asp Ser Ile Thr Gly Asn Ala His Asp Asn Phe Leu Ala Gly Gly Ser 
            820                 825                 830         


Gly Asp Asp Arg Leu Asp Gly Gly Ala Gly Asn Asp Thr Leu Val Gly 
        835                 840                 845             


Gly Glu Gly Gln Asn Thr Val Ile Gly Gly Ala Gly Asp Asp Val Phe 
    850                 855                 860                 


Leu Gln Asp Leu Gly Val Trp Ser Asn Gln Leu Asp Gly Gly Ala Gly 
865                 870                 875                 880 


Val Asp Thr Val Lys Tyr Asn Val His Gln Pro Ser Glu Glu Arg Leu 
                885                 890                 895     


Glu Arg Met Gly Asp Thr Gly Ile His Ala Asp Leu Gln Lys Gly Thr 
            900                 905                 910         


Val Glu Lys Trp Pro Ala Leu Asn Leu Phe Ser Val Asp His Val Lys 
        915                 920                 925             


Asn Ile Glu Asn Leu His Gly Ser Arg Leu Asn Asp Arg Ile Ala Gly 
    930                 935                 940                 


Asp Asp Gln Asp Asn Glu Leu Trp Gly His Asp Gly Asn Asp Thr Ile 
945                 950                 955                 960 


Arg Gly Arg Gly Gly Asp Asp Ile Leu Arg Gly Gly Leu Gly Leu Asp 
                965                 970                 975     


Thr Leu Tyr Gly Glu Asp Gly Asn Asp Ile Phe Leu Gln Asp Asp Glu 
            980                 985                 990         


Thr Val Ser Asp Asp Ile Asp Gly  Gly Ala Gly Leu Asp  Thr Val Asp 
        995                 1000                 1005             


Tyr Ser  Ala Met Ile His Pro  Gly Arg Ile Val Ala  Pro His Glu 
    1010                 1015                 1020             


Tyr Gly  Phe Gly Ile Glu Ala  Asp Leu Ser Arg Glu  Trp Val Arg 
    1025                 1030                 1035             


Lys Ala  Ser Ala Leu Gly Val  Asp Tyr Tyr Asp Asn  Val Arg Asn 
    1040                 1045                 1050             


Val Glu  Asn Val Ile Gly Thr  Ser Met Lys Asp Val  Leu Ile Gly 
    1055                 1060                 1065             


Asp Ala  Gln Ala Asn Thr Leu  Met Gly Gln Gly Gly  Asp Asp Thr 
    1070                 1075                 1080             


Val Arg  Gly Gly Asp Gly Asp  Asp Leu Leu Phe Gly  Gly Asp Gly 
    1085                 1090                 1095             


Asn Asp  Met Leu Tyr Gly Asp  Ala Gly Asn Asp Thr  Leu Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Gly Asp Asp Thr Leu  Glu Gly Gly Ala Gly  Asn Asp Trp 
    1115                 1120                 1125             


Phe Gly  Gln Thr Gln Ala Arg  Glu His Asp Val Leu  Arg Gly Gly 
    1130                 1135                 1140             


Asp Gly  Val Asp Thr Val Asp  Tyr Ser Gln Thr Gly  Ala His Ala 
    1145                 1150                 1155             


Gly Ile  Ala Ala Gly Arg Ile  Gly Leu Gly Ile Leu  Ala Asp Leu 
    1160                 1165                 1170             


Gly Ala  Gly Arg Val Asp Lys  Leu Gly Glu Ala Gly  Ser Ser Ala 
    1175                 1180                 1185             


Tyr Asp  Thr Val Ser Gly Ile  Glu Asn Val Val Gly  Thr Glu Leu 
    1190                 1195                 1200             


Ala Asp  Arg Ile Thr Gly Asp  Ala Gln Ala Asn Val  Leu Arg Gly 
    1205                 1210                 1215             


Ala Gly  Gly Ala Asp Val Leu  Ala Gly Gly Glu Gly  Asp Asp Val 
    1220                 1225                 1230             


Leu Leu  Gly Gly Asp Gly Asp  Asp Gln Leu Ser Gly  Asp Ala Gly 
    1235                 1240                 1245             


Arg Asp  Arg Leu Tyr Gly Glu  Ala Gly Asp Asp Trp  Phe Phe Gln 
    1250                 1255                 1260             


Asp Ala  Ala Asn Ala Gly Asn  Leu Leu Asp Gly Gly  Asp Gly Arg 
    1265                 1270                 1275             


Asp Thr  Val Asp Phe Ser Gly  Pro Gly Arg Gly Leu  Asp Ala Gly 
    1280                 1285                 1290             


Ala Lys  Gly Val Phe Leu Ser  Leu Gly Lys Gly Phe  Ala Ser Leu 
    1295                 1300                 1305             


Met Asp  Glu Pro Glu Thr Ser  Asn Val Leu Arg Asn  Ile Glu Asn 
    1310                 1315                 1320             


Ala Val  Gly Ser Ala Arg Asp  Asp Val Leu Ile Gly  Asp Ala Gly 
    1325                 1330                 1335             


Ala Asn  Val Leu Asn Gly Leu  Ala Gly Asn Asp Val  Leu Ser Gly 
    1340                 1345                 1350             


Gly Ala  Gly Asp Asp Val Leu  Leu Gly Asp Glu Gly  Ser Asp Leu 
    1355                 1360                 1365             


Leu Ser  Gly Asp Ala Gly Asn  Asp Asp Leu Phe Gly  Gly Gln Gly 
    1370                 1375                 1380             


Asp Asp  Thr Tyr Leu Phe Gly  Val Gly Tyr Gly His  Asp Thr Ile 
    1385                 1390                 1395             


Tyr Glu  Ser Gly Gly Gly His  Asp Thr Ile Arg Ile  Asn Ala Gly 
    1400                 1405                 1410             


Ala Asp  Gln Leu Trp Phe Ala  Arg Gln Gly Asn Asp  Leu Glu Ile 
    1415                 1420                 1425             


Arg Ile  Leu Gly Thr Asp Asp  Ala Leu Thr Val His  Asp Trp Tyr 
    1430                 1435                 1440             


Arg Asp  Ala Asp His Arg Val  Glu Ile Ile His Ala  Ala Asn Gln 
    1445                 1450                 1455             


Ala Val  Asp Gln Ala Gly Ile  Glu Lys Leu Val Glu  Ala Met Ala 
    1460                 1465                 1470             


Gln Tyr  Pro Asp Pro Gly Ala  Ala Ala Ala Ala Pro  Pro Ala Ala 
    1475                 1480                 1485             


Arg Val  Pro Asp Thr Leu Met  Gln Ser Leu Ala Val  Asn Trp Arg 
    1490                 1495                 1500             


<210>  15
<211>  1613
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide 1-227 + 321-1706 of SEQ ID NO:6

<400>  15

Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu 
1               5                   10                  15      


Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys 
            20                  25                  30          


Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr 
        35                  40                  45              


Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala 
    50                  55                  60                  


Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro 
65                  70                  75                  80  


Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala 
                85                  90                  95      


Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp 
            100                 105                 110         


Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu 
        115                 120                 125             


Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr 
    130                 135                 140                 


Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala 
145                 150                 155                 160 


Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val 
                165                 170                 175     


Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe 
            180                 185                 190         


Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser 
        195                 200                 205             


Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg 
    210                 215                 220                 


Ala Ala Ser Glu Ser Gln Met Leu Thr Arg Gly Gln Leu Lys Glu Tyr 
225                 230                 235                 240 


Ile Gly Gln Gln Arg Gly Glu Gly Tyr Val Phe Tyr Glu Asn Arg Ala 
                245                 250                 255     


Tyr Gly Val Ala Gly Lys Ser Leu Phe Asp Asp Gly Leu Gly Ala Ala 
            260                 265                 270         


Pro Gly Val Pro Gly Gly Arg Ser Lys Ser Ser Pro Asp Val Leu Glu 
        275                 280                 285             


Thr Val Pro Ala Ser Pro Gly Leu Arg Arg Pro Ser Leu Gly Ala Val 
    290                 295                 300                 


Glu Arg Gln Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly Ser Arg 
305                 310                 315                 320 


Ser Phe Ser Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu Ala Ala 
                325                 330                 335     


Glu Leu Glu Met Thr Arg Gln Val Leu His Ala Gly Ala Arg Gln Asp 
            340                 345                 350         


Asp Ala Glu Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly Gln Arg 
        355                 360                 365             


Ala Leu Gln Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu Val His 
    370                 375                 380                 


Ala Ile Ala Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr Asn Thr 
385                 390                 395                 400 


Pro Gln Glu Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu Gly Glu 
                405                 410                 415     


Ala Ser Ser Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg Gly Ser 
            420                 425                 430         


Ser Arg Trp Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met Ala Leu 
        435                 440                 445             


Gly Gly Gly Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu Thr Asp 
    450                 455                 460                 


Asp Ala Pro Ala Gly Gln Lys Ala Ala Val Gly Ala Glu Ile Ala Leu 
465                 470                 475                 480 


Gln Leu Thr Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu Ala 
                485                 490                 495     


Leu Ala Ala Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly Ala 
            500                 505                 510         


Ser Ala Gly Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro Met 
        515                 520                 525             


Glu Ile Tyr Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu Asp 
    530                 535                 540                 


Lys Leu Ala Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala Leu 
545                 550                 555                 560 


Leu Ala Gln Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val Ala 
                565                 570                 575     


Gly Val Ser Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile Ala 
            580                 585                 590         


Ala Ala Ala Ser Val Val Gly Ala Pro Val Ala Val Val Thr Ser Leu 
        595                 600                 605             


Leu Thr Gly Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro Ile 
    610                 615                 620                 


Ile Glu Lys Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu Gly 
625                 630                 635                 640 


Gly Pro Gln Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu Gln 
                645                 650                 655     


Leu Ala Asn Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln Ala 
            660                 665                 670         


Gly Trp Asn Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile Ser 
        675                 680                 685             


Lys Ser Ala Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn Leu 
    690                 695                 700                 


Lys Ser Ala Asp Val Phe Val Asp Arg Phe Ile Gln Gly Glu Arg Val 
705                 710                 715                 720 


Ala Gly Gln Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp Ile 
                725                 730                 735     


Ala Ser Arg Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro Leu 
            740                 745                 750         


Ala Ala Pro Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys Ser 
        755                 760                 765             


Glu Phe Thr Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp Arg 
    770                 775                 780                 


Ile Arg Asp Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val Val 
785                 790                 795                 800 


Ser Gln Leu Val Asp Ala Asn Gly Val Leu Lys His Ser Ile Lys Leu 
                805                 810                 815     


Glu Val Ile Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn Ala Ser 
            820                 825                 830         


Arg Ile His Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser Tyr Ala 
        835                 840                 845             


Ala Leu Gly Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly Glu Arg 
    850                 855                 860                 


Phe Asn Val Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg Glu Gly 
865                 870                 875                 880 


Val Ala Thr Gln Lys Thr Ala Tyr Gly Lys Arg Thr Glu Asn Val Gln 
                885                 890                 895     


Tyr Arg His Val Glu Leu Ala Arg Val Gly Gln Leu Val Glu Val Asp 
            900                 905                 910         


Thr Leu Glu His Val Gln His Ile Ile Gly Gly Ala Gly Asn Asp Ser 
        915                 920                 925             


Ile Thr Gly Asn Ala His Asp Asn Phe Leu Ala Gly Gly Ala Gly Asp 
    930                 935                 940                 


Asp Arg Leu Asp Gly Gly Ala Gly Asn Asp Thr Leu Val Gly Gly Glu 
945                 950                 955                 960 


Gly His Asn Thr Val Val Gly Gly Ala Gly Asp Asp Val Phe Leu Gln 
                965                 970                 975     


Asp Leu Gly Val Trp Ser Asn Gln Leu Asp Gly Gly Ala Gly Val Asp 
            980                 985                 990         


Thr Val Lys Tyr Asn Val His Gln  Pro Ser Glu Glu Arg  Leu Glu Arg 
        995                 1000                 1005             


Met Gly  Asp Thr Gly Ile His  Ala Asp Leu Gln Lys  Gly Thr Val 
    1010                 1015                 1020             


Glu Lys  Trp Pro Ala Leu Asn  Leu Phe Ser Val Asp  His Val Lys 
    1025                 1030                 1035             


Asn Ile  Glu Asn Leu His Gly  Ser Ser Leu Asn Asp  Ser Ile Ala 
    1040                 1045                 1050             


Gly Asp  Asp Arg Asp Asn Glu  Leu Trp Gly Asp Asp  Gly Asn Asp 
    1055                 1060                 1065             


Thr Ile  His Gly Arg Gly Gly  Asp Asp Ile Leu Arg  Gly Gly Leu 
    1070                 1075                 1080             


Gly Leu  Asp Thr Leu Tyr Gly  Glu Asp Gly Asn Asp  Ile Phe Leu 
    1085                 1090                 1095             


Gln Asp  Asp Glu Thr Val Ser  Asp Asp Ile Asp Gly  Gly Ala Gly 
    1100                 1105                 1110             


Leu Asp  Thr Val Asp Tyr Ser  Ala Met Ile His Ala  Gly Lys Ile 
    1115                 1120                 1125             


Val Ala  Pro His Glu Tyr Gly  Phe Gly Ile Glu Ala  Asp Leu Ser 
    1130                 1135                 1140             


Glu Gly  Trp Val Arg Lys Ala  Ala Arg Arg Gly Met  Gly Tyr Tyr 
    1145                 1150                 1155             


Asp Ser  Val Arg Ser Val Glu  Asn Val Ile Gly Thr  Ser Met Lys 
    1160                 1165                 1170             


Asp Val  Leu Ile Gly Asp Ala  Gln Ala Asn Thr Leu  Met Gly Gln 
    1175                 1180                 1185             


Gly Gly  Asp Asp Thr Val Arg  Gly Gly Asp Gly Asp  Asp Leu Leu 
    1190                 1195                 1200             


Phe Gly  Gly Asp Gly Asn Asp  Met Leu Tyr Gly Asp  Ala Gly Asn 
    1205                 1210                 1215             


Asp Thr  Leu Tyr Gly Gly Leu  Gly Asp Asp Thr Leu  Glu Gly Gly 
    1220                 1225                 1230             


Ala Gly  Asn Asp Trp Phe Gly  Gln Thr Pro Ala Arg  Glu His Asp 
    1235                 1240                 1245             


Val Leu  Arg Gly Gly Ala Gly  Val Asp Thr Val Asp  Tyr Ser Gln 
    1250                 1255                 1260             


Ala Gly  Ala His Ala Gly Val  Ala Thr Gly Arg Ile  Gly Leu Gly 
    1265                 1270                 1275             


Ile Leu  Ala Asp Leu Gly Ala  Gly Arg Val Asp Lys  Leu Gly Glu 
    1280                 1285                 1290             


Ala Gly  Ser Ser Ala Tyr Asp  Thr Val Ser Gly Ile  Glu Asn Val 
    1295                 1300                 1305             


Val Gly  Thr Glu Leu Ala Asp  Arg Ile Thr Gly Asp  Ala Gln Ala 
    1310                 1315                 1320             


Asn Val  Leu Arg Gly Ala Gly  Gly Ala Asp Val Leu  Ala Gly Gly 
    1325                 1330                 1335             


Glu Gly  Asp Asp Val Leu Leu  Gly Gly Glu Gly Asp  Asp Gln Leu 
    1340                 1345                 1350             


Ser Gly  Asp Ala Gly Arg Asp  Arg Leu Tyr Gly Glu  Ala Gly Asp 
    1355                 1360                 1365             


Asp Trp  Phe Phe Gln Asp Ala  Ala Asn Ala Gly Asn  Leu Leu Asp 
    1370                 1375                 1380             


Gly Gly  Asp Gly Asn Asp Thr  Val Asp Phe Ser Gly  Pro Gly Arg 
    1385                 1390                 1395             


Gly Leu  Asp Ala Gly Ala Lys  Gly Val Phe Leu Ser  Leu Gly Lys 
    1400                 1405                 1410             


Gly Phe  Ala Ser Leu Met Asp  Glu Pro Glu Thr Ser  Asn Val Leu 
    1415                 1420                 1425             


Arg His  Ile Glu Asn Ala Val  Gly Ser Val Arg Asp  Asp Val Leu 
    1430                 1435                 1440             


Ile Gly  Asp Ala Gly Ala Asn  Val Leu Asn Gly Leu  Ala Gly Asn 
    1445                 1450                 1455             


Asp Val  Leu Ser Gly Gly Ala  Gly Asp Asp Val Leu  Leu Gly Asp 
    1460                 1465                 1470             


Glu Gly  Ser Asp Leu Leu Ser  Gly Asp Ala Gly Asn  Asp Asp Leu 
    1475                 1480                 1485             


Phe Gly  Gly Gln Gly Asp Asp  Thr Tyr Leu Phe Gly  Ala Gly Tyr 
    1490                 1495                 1500             


Gly His  Asp Thr Ile Tyr Glu  Ser Gly Gly Gly His  Asp Thr Ile 
    1505                 1510                 1515             


Arg Ile  Asn Ala Gly Ala Asp  Gln Leu Trp Phe Ala  Arg Gln Gly 
    1520                 1525                 1530             


Asn Asp  Leu Glu Ile Arg Ile  Leu Gly Thr Asp Asp  Ala Leu Thr 
    1535                 1540                 1545             


Val His  Asp Trp Tyr Arg Asp  Ala Asp His Arg Val  Glu Ala Ile 
    1550                 1555                 1560             


His Ala  Ala Asn Gln Ala Ile  Asp Pro Ala Gly Ile  Glu Lys Leu 
    1565                 1570                 1575             


Val Glu  Ala Met Ala Gln Tyr  Pro Asp Pro Gly Ala  Ala Ala Ala 
    1580                 1585                 1590             


Ala Pro  Pro Ala Ala Arg Val  Pro Asp Thr Leu Met  Gln Ser Leu 
    1595                 1600                 1605             


Ala Val  Asn Trp Arg 
    1610             


<210>  16
<211>  1503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide 1-183 + 387-1706 of SEQ ID NO:6

<400>  16

Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu 
1               5                   10                  15      


Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys 
            20                  25                  30          


Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr 
        35                  40                  45              


Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala 
    50                  55                  60                  


Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro 
65                  70                  75                  80  


Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala 
                85                  90                  95      


Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp 
            100                 105                 110         


Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu 
        115                 120                 125             


Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr 
    130                 135                 140                 


Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala 
145                 150                 155                 160 


Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val 
                165                 170                 175     


Ile Gly Asn Ala Ala Gly Ile Pro Gly Leu Arg Arg Pro Ser Leu Gly 
            180                 185                 190         


Ala Val Glu Arg Gln Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly 
        195                 200                 205             


Ser Arg Ser Phe Ser Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu 
    210                 215                 220                 


Ala Ala Glu Leu Glu Met Thr Arg Gln Val Leu His Ala Gly Ala Arg 
225                 230                 235                 240 


Gln Asp Asp Ala Glu Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly 
                245                 250                 255     


Gln Arg Ala Leu Gln Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu 
            260                 265                 270         


Val His Ala Ile Ala Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr 
        275                 280                 285             


Asn Thr Pro Gln Glu Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu 
    290                 295                 300                 


Gly Glu Ala Ser Ser Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg 
305                 310                 315                 320 


Gly Ser Ser Arg Trp Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met 
                325                 330                 335     


Ala Leu Gly Gly Gly Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu 
            340                 345                 350         


Thr Asp Asp Ala Pro Ala Gly Gln Lys Ala Ala Val Gly Ala Glu Ile 
        355                 360                 365             


Ala Leu Gln Leu Thr Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala 
    370                 375                 380                 


Leu Ala Leu Ala Ala Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala 
385                 390                 395                 400 


Gly Ala Ser Ala Gly Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser 
                405                 410                 415     


Pro Met Glu Ile Tyr Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln 
            420                 425                 430         


Leu Asp Lys Leu Ala Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp 
        435                 440                 445             


Ala Leu Leu Ala Gln Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala 
    450                 455                 460                 


Val Ala Gly Val Ser Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser 
465                 470                 475                 480 


Ile Ala Ala Ala Ala Ser Val Val Gly Ala Pro Val Ala Val Val Thr 
                485                 490                 495     


Ser Leu Leu Thr Gly Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln 
            500                 505                 510         


Pro Ile Ile Glu Lys Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu 
        515                 520                 525             


Leu Gly Gly Pro Gln Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His 
    530                 535                 540                 


Glu Gln Leu Ala Asn Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu 
545                 550                 555                 560 


Gln Ala Gly Trp Asn Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu 
                565                 570                 575     


Ile Ser Lys Ser Ala Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp 
            580                 585                 590         


Asn Leu Lys Ser Ala Asp Val Phe Val Asp Arg Phe Ile Gln Gly Glu 
        595                 600                 605             


Arg Val Ala Gly Gln Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile 
    610                 615                 620                 


Asp Ile Ala Ser Arg Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr 
625                 630                 635                 640 


Pro Leu Ala Ala Pro Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly 
                645                 650                 655     


Lys Ser Glu Phe Thr Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg 
            660                 665                 670         


Trp Arg Ile Arg Asp Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys 
        675                 680                 685             


Val Val Ser Gln Leu Val Asp Ala Asn Gly Val Leu Lys His Ser Ile 
    690                 695                 700                 


Lys Leu Glu Val Ile Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn 
705                 710                 715                 720 


Ala Ser Arg Ile His Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser 
                725                 730                 735     


Tyr Ala Ala Leu Gly Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly 
            740                 745                 750         


Glu Arg Phe Asn Val Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg 
        755                 760                 765             


Glu Gly Val Ala Thr Gln Lys Thr Ala Tyr Gly Lys Arg Thr Glu Asn 
    770                 775                 780                 


Val Gln Tyr Arg His Val Glu Leu Ala Arg Val Gly Gln Leu Val Glu 
785                 790                 795                 800 


Val Asp Thr Leu Glu His Val Gln His Ile Ile Gly Gly Ala Gly Asn 
                805                 810                 815     


Asp Ser Ile Thr Gly Asn Ala His Asp Asn Phe Leu Ala Gly Gly Ala 
            820                 825                 830         


Gly Asp Asp Arg Leu Asp Gly Gly Ala Gly Asn Asp Thr Leu Val Gly 
        835                 840                 845             


Gly Glu Gly His Asn Thr Val Val Gly Gly Ala Gly Asp Asp Val Phe 
    850                 855                 860                 


Leu Gln Asp Leu Gly Val Trp Ser Asn Gln Leu Asp Gly Gly Ala Gly 
865                 870                 875                 880 


Val Asp Thr Val Lys Tyr Asn Val His Gln Pro Ser Glu Glu Arg Leu 
                885                 890                 895     


Glu Arg Met Gly Asp Thr Gly Ile His Ala Asp Leu Gln Lys Gly Thr 
            900                 905                 910         


Val Glu Lys Trp Pro Ala Leu Asn Leu Phe Ser Val Asp His Val Lys 
        915                 920                 925             


Asn Ile Glu Asn Leu His Gly Ser Ser Leu Asn Asp Ser Ile Ala Gly 
    930                 935                 940                 


Asp Asp Arg Asp Asn Glu Leu Trp Gly Asp Asp Gly Asn Asp Thr Ile 
945                 950                 955                 960 


His Gly Arg Gly Gly Asp Asp Ile Leu Arg Gly Gly Leu Gly Leu Asp 
                965                 970                 975     


Thr Leu Tyr Gly Glu Asp Gly Asn Asp Ile Phe Leu Gln Asp Asp Glu 
            980                 985                 990         


Thr Val Ser Asp Asp Ile Asp Gly  Gly Ala Gly Leu Asp  Thr Val Asp 
        995                 1000                 1005             


Tyr Ser  Ala Met Ile His Ala  Gly Lys Ile Val Ala  Pro His Glu 
    1010                 1015                 1020             


Tyr Gly  Phe Gly Ile Glu Ala  Asp Leu Ser Glu Gly  Trp Val Arg 
    1025                 1030                 1035             


Lys Ala  Ala Arg Arg Gly Met  Gly Tyr Tyr Asp Ser  Val Arg Ser 
    1040                 1045                 1050             


Val Glu  Asn Val Ile Gly Thr  Ser Met Lys Asp Val  Leu Ile Gly 
    1055                 1060                 1065             


Asp Ala  Gln Ala Asn Thr Leu  Met Gly Gln Gly Gly  Asp Asp Thr 
    1070                 1075                 1080             


Val Arg  Gly Gly Asp Gly Asp  Asp Leu Leu Phe Gly  Gly Asp Gly 
    1085                 1090                 1095             


Asn Asp  Met Leu Tyr Gly Asp  Ala Gly Asn Asp Thr  Leu Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Gly Asp Asp Thr Leu  Glu Gly Gly Ala Gly  Asn Asp Trp 
    1115                 1120                 1125             


Phe Gly  Gln Thr Pro Ala Arg  Glu His Asp Val Leu  Arg Gly Gly 
    1130                 1135                 1140             


Ala Gly  Val Asp Thr Val Asp  Tyr Ser Gln Ala Gly  Ala His Ala 
    1145                 1150                 1155             


Gly Val  Ala Thr Gly Arg Ile  Gly Leu Gly Ile Leu  Ala Asp Leu 
    1160                 1165                 1170             


Gly Ala  Gly Arg Val Asp Lys  Leu Gly Glu Ala Gly  Ser Ser Ala 
    1175                 1180                 1185             


Tyr Asp  Thr Val Ser Gly Ile  Glu Asn Val Val Gly  Thr Glu Leu 
    1190                 1195                 1200             


Ala Asp  Arg Ile Thr Gly Asp  Ala Gln Ala Asn Val  Leu Arg Gly 
    1205                 1210                 1215             


Ala Gly  Gly Ala Asp Val Leu  Ala Gly Gly Glu Gly  Asp Asp Val 
    1220                 1225                 1230             


Leu Leu  Gly Gly Glu Gly Asp  Asp Gln Leu Ser Gly  Asp Ala Gly 
    1235                 1240                 1245             


Arg Asp  Arg Leu Tyr Gly Glu  Ala Gly Asp Asp Trp  Phe Phe Gln 
    1250                 1255                 1260             


Asp Ala  Ala Asn Ala Gly Asn  Leu Leu Asp Gly Gly  Asp Gly Asn 
    1265                 1270                 1275             


Asp Thr  Val Asp Phe Ser Gly  Pro Gly Arg Gly Leu  Asp Ala Gly 
    1280                 1285                 1290             


Ala Lys  Gly Val Phe Leu Ser  Leu Gly Lys Gly Phe  Ala Ser Leu 
    1295                 1300                 1305             


Met Asp  Glu Pro Glu Thr Ser  Asn Val Leu Arg His  Ile Glu Asn 
    1310                 1315                 1320             


Ala Val  Gly Ser Val Arg Asp  Asp Val Leu Ile Gly  Asp Ala Gly 
    1325                 1330                 1335             


Ala Asn  Val Leu Asn Gly Leu  Ala Gly Asn Asp Val  Leu Ser Gly 
    1340                 1345                 1350             


Gly Ala  Gly Asp Asp Val Leu  Leu Gly Asp Glu Gly  Ser Asp Leu 
    1355                 1360                 1365             


Leu Ser  Gly Asp Ala Gly Asn  Asp Asp Leu Phe Gly  Gly Gln Gly 
    1370                 1375                 1380             


Asp Asp  Thr Tyr Leu Phe Gly  Ala Gly Tyr Gly His  Asp Thr Ile 
    1385                 1390                 1395             


Tyr Glu  Ser Gly Gly Gly His  Asp Thr Ile Arg Ile  Asn Ala Gly 
    1400                 1405                 1410             


Ala Asp  Gln Leu Trp Phe Ala  Arg Gln Gly Asn Asp  Leu Glu Ile 
    1415                 1420                 1425             


Arg Ile  Leu Gly Thr Asp Asp  Ala Leu Thr Val His  Asp Trp Tyr 
    1430                 1435                 1440             


Arg Asp  Ala Asp His Arg Val  Glu Ala Ile His Ala  Ala Asn Gln 
    1445                 1450                 1455             


Ala Ile  Asp Pro Ala Gly Ile  Glu Lys Leu Val Glu  Ala Met Ala 
    1460                 1465                 1470             


Gln Tyr  Pro Asp Pro Gly Ala  Ala Ala Ala Ala Pro  Pro Ala Ala 
    1475                 1480                 1485             


Arg Val  Pro Asp Thr Leu Met  Gln Ser Leu Ala Val  Asn Trp Arg 
    1490                 1495                 1500             


<210>  17
<211>  1612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide 1-227 + 321-1705 of SEQ ID NO:8

<400>  17

Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu 
1               5                   10                  15      


Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys 
            20                  25                  30          


Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr 
        35                  40                  45              


Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala 
    50                  55                  60                  


Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro 
65                  70                  75                  80  


Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala 
                85                  90                  95      


Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp 
            100                 105                 110         


Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu 
        115                 120                 125             


Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr 
    130                 135                 140                 


Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala 
145                 150                 155                 160 


Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val 
                165                 170                 175     


Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe 
            180                 185                 190         


Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser 
        195                 200                 205             


Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg 
    210                 215                 220                 


Ala Ala Ser Glu Ser Gln Met Leu Thr Arg Gly Gln Leu Lys Glu Tyr 
225                 230                 235                 240 


Ile Gly Gln Gln Arg Gly Glu Gly Tyr Val Phe Tyr Glu Asn Arg Ala 
                245                 250                 255     


Tyr Gly Val Ala Gly Lys Ser Leu Phe Asp Asp Gly Leu Gly Ala Ala 
            260                 265                 270         


Pro Gly Val Pro Gly Arg Arg Ser Lys Ser Ser Pro Asp Val Leu Glu 
        275                 280                 285             


Thr Val Pro Ala Ser Pro Gly Leu Arg Arg Pro Ser Leu Gly Ala Val 
    290                 295                 300                 


Glu Arg Gln Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly Ser Arg 
305                 310                 315                 320 


Ser Phe Ser Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu Ala Ala 
                325                 330                 335     


Glu Leu Glu Met Thr Arg Gln Val Leu His Ala Gly Ala Arg Gln Asp 
            340                 345                 350         


Asp Ala Glu Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly Gln Arg 
        355                 360                 365             


Ala Leu Gln Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu Val His 
    370                 375                 380                 


Ala Ile Ala Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr Asn Thr 
385                 390                 395                 400 


Pro Gln Glu Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu Gly Glu 
                405                 410                 415     


Ala Ser Ser Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg Gly Ser 
            420                 425                 430         


Ser Arg Trp Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met Ala Leu 
        435                 440                 445             


Gly Gly Gly Ile Gly Ala Val Gly Ala Gly Met Ser Leu Thr Asp Asp 
    450                 455                 460                 


Ala Pro Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile Ala Leu Gln 
465                 470                 475                 480 


Leu Thr Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu Ala Leu 
                485                 490                 495     


Ala Ala Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly Ala Ser 
            500                 505                 510         


Ala Gly Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro Met Glu 
        515                 520                 525             


Ile Tyr Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu Asp Lys 
    530                 535                 540                 


Leu Ala Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala Leu Leu 
545                 550                 555                 560 


Ala Gln Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val Ala Gly 
                565                 570                 575     


Val Ser Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile Ala Ala 
            580                 585                 590         


Ala Ala Ser Val Val Gly Ala Pro Val Ala Val Val Thr Ser Leu Leu 
        595                 600                 605             


Thr Gly Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro Ile Ile 
    610                 615                 620                 


Glu Lys Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu Gly Gly 
625                 630                 635                 640 


Pro Gln Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu Gln Leu 
                645                 650                 655     


Ala Asn Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln Ala Gly 
            660                 665                 670         


Trp Asn Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile Ser Lys 
        675                 680                 685             


Ser Ala Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn Leu Lys 
    690                 695                 700                 


Ser Ala Asp Val Phe Val Asp Arg Phe Ile Gln Gly Glu Arg Val Ala 
705                 710                 715                 720 


Gly Gln Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp Ile Ala 
                725                 730                 735     


Ser Arg Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro Leu Ala 
            740                 745                 750         


Ala Pro Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys Ser Glu 
        755                 760                 765             


Phe Thr Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp Arg Ile 
    770                 775                 780                 


Arg Asp Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val Val Ser 
785                 790                 795                 800 


Gln Leu Val Asp Ala Asn Gly Val Leu Lys His Ser Ile Lys Leu Glu 
                805                 810                 815     


Val Ile Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn Ala Ser Arg 
            820                 825                 830         


Ile His Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser Tyr Ala Ala 
        835                 840                 845             


Leu Gly Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly Glu Arg Phe 
    850                 855                 860                 


Asn Val Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg Glu Gly Val 
865                 870                 875                 880 


Ala Thr Gln Lys Thr Ala Tyr Gly Lys Arg Thr Glu Asn Val Gln Tyr 
                885                 890                 895     


Arg His Val Glu Leu Ala Arg Val Gly Gln Leu Val Glu Val Asp Thr 
            900                 905                 910         


Leu Glu His Val Gln His Ile Ile Gly Gly Ala Gly Asn Asp Ser Ile 
        915                 920                 925             


Thr Gly Asn Ala His Asp Asn Phe Leu Ala Gly Gly Ala Gly Asp Asp 
    930                 935                 940                 


Arg Leu Asp Gly Gly Ala Gly Asn Asp Thr Leu Val Gly Gly Glu Gly 
945                 950                 955                 960 


His Asn Thr Val Val Gly Gly Ala Gly Asp Asp Val Phe Leu Gln Asp 
                965                 970                 975     


Leu Gly Val Trp Ser Asn Gln Leu Asp Gly Gly Ala Gly Val Asp Thr 
            980                 985                 990         


Val Lys Tyr Asn Val His Gln Pro  Ser Glu Glu Arg Leu  Glu Arg Met 
        995                 1000                 1005             


Gly Asp  Thr Gly Ile His Ala  Asp Leu Gln Lys Gly  Thr Val Glu 
    1010                 1015                 1020             


Lys Trp  Pro Ala Leu Asn Leu  Phe Ser Val Asp His  Val Lys Asn 
    1025                 1030                 1035             


Ile Glu  Asn Leu His Gly Ser  Ser Leu Asn Asp Ser  Ile Ala Gly 
    1040                 1045                 1050             


Asp Asp  Arg Asp Asn Glu Leu  Trp Gly Asp Asp Gly  Asn Asp Thr 
    1055                 1060                 1065             


Ile His  Gly Arg Gly Gly Asp  Asp Ile Leu Arg Gly  Gly Leu Gly 
    1070                 1075                 1080             


Leu Asp  Thr Leu Tyr Gly Glu  Asp Gly Asn Asp Ile  Phe Leu Gln 
    1085                 1090                 1095             


Asp Asp  Glu Thr Val Ser Asp  Asp Ile Asp Gly Gly  Ala Gly Leu 
    1100                 1105                 1110             


Asp Thr  Val Asp Tyr Ser Ala  Met Ile His Ala Gly  Lys Ile Val 
    1115                 1120                 1125             


Ala Pro  His Glu Tyr Gly Phe  Gly Ile Glu Ala Asp  Leu Ser Glu 
    1130                 1135                 1140             


Gly Trp  Val Arg Lys Ala Ala  Arg Arg Gly Met Asp  Tyr Tyr Asp 
    1145                 1150                 1155             


Ser Val  Arg Ser Val Glu Asn  Val Ile Gly Thr Ser  Met Lys Asp 
    1160                 1165                 1170             


Val Leu  Ile Gly Asp Ala Gln  Ala Asn Thr Leu Met  Gly Gln Gly 
    1175                 1180                 1185             


Gly Asp  Asp Thr Val Arg Gly  Gly Asp Gly Asp Asp  Leu Leu Phe 
    1190                 1195                 1200             


Gly Gly  Asp Gly Asn Asp Met  Leu Tyr Gly Asp Ala  Gly Asn Asp 
    1205                 1210                 1215             


Thr Leu  Tyr Gly Gly Leu Gly  Asp Asp Thr Leu Glu  Gly Gly Ala 
    1220                 1225                 1230             


Gly Asn  Asp Trp Phe Gly Gln  Thr Pro Ala Arg Glu  His Asp Val 
    1235                 1240                 1245             


Leu Arg  Gly Gly Ala Gly Val  Asp Thr Val Asp Tyr  Ser Gln Ala 
    1250                 1255                 1260             


Gly Ala  His Ala Gly Val Ala  Thr Gly Arg Ile Gly  Leu Gly Ile 
    1265                 1270                 1275             


Leu Ala  Asp Leu Gly Ala Gly  Arg Val Asp Lys Leu  Gly Glu Ala 
    1280                 1285                 1290             


Gly Ser  Ser Ala Tyr Asp Thr  Val Ser Gly Ile Glu  Asn Val Val 
    1295                 1300                 1305             


Gly Thr  Glu Leu Ala Asp Arg  Ile Thr Gly Asp Ala  Gln Ala Asn 
    1310                 1315                 1320             


Val Leu  Arg Gly Ala Gly Gly  Ala Asp Val Leu Ala  Gly Gly Glu 
    1325                 1330                 1335             


Gly Asp  Asp Val Leu Leu Gly  Gly Asp Gly Asp Asp  Gln Leu Ser 
    1340                 1345                 1350             


Gly Asp  Ala Gly Arg Asp Arg  Leu Tyr Gly Glu Ala  Gly Asp Asp 
    1355                 1360                 1365             


Trp Phe  Phe Gln Asp Ala Ala  Asn Ala Gly Asn Leu  Leu Asp Gly 
    1370                 1375                 1380             


Gly Asp  Gly Asn Asp Thr Val  Asp Phe Ser Gly Pro  Gly Arg Gly 
    1385                 1390                 1395             


Leu Asp  Ala Gly Ala Lys Gly  Val Phe Leu Ser Leu  Gly Lys Gly 
    1400                 1405                 1410             


Phe Ala  Ser Leu Met Asp Glu  Pro Glu Thr Ser Asn  Val Leu Arg 
    1415                 1420                 1425             


His Ile  Glu Asn Ala Val Gly  Ser Val Arg Asp Asp  Val Leu Ile 
    1430                 1435                 1440             


Gly Asp  Ala Gly Ala Asn Val  Leu Asn Gly Leu Ala  Gly Asn Asp 
    1445                 1450                 1455             


Val Leu  Ser Gly Gly Ala Gly  Asp Asp Val Leu Leu  Gly Asp Glu 
    1460                 1465                 1470             


Gly Ser  Asp Leu Leu Ser Gly  Asp Ala Gly Asn Asp  Asp Leu Phe 
    1475                 1480                 1485             


Gly Gly  Gln Gly Asp Asp Thr  Tyr Leu Phe Gly Ala  Gly Tyr Gly 
    1490                 1495                 1500             


His Asp  Thr Ile Tyr Glu Ser  Gly Gly Gly His Asp  Thr Ile Arg 
    1505                 1510                 1515             


Ile Asn  Ala Gly Ala Asp Gln  Leu Trp Phe Ala Arg  Gln Gly Asn 
    1520                 1525                 1530             


Asp Leu  Glu Ile Arg Ile Leu  Gly Thr Asp Asp Ala  Leu Thr Val 
    1535                 1540                 1545             


His Asp  Trp Tyr Arg Asp Ala  Asp His Arg Val Glu  Ala Ile His 
    1550                 1555                 1560             


Ala Ala  Asn Gln Ala Ile Asp  Pro Ala Gly Ile Glu  Lys Leu Val 
    1565                 1570                 1575             


Glu Ala  Met Ala Gln Tyr Pro  Asp Pro Gly Ala Ala  Ala Ala Ala 
    1580                 1585                 1590             


Pro Pro  Ala Ala Arg Val Pro  Asp Thr Leu Met Gln  Ser Leu Ala 
    1595                 1600                 1605             


Val Asn  Trp Arg 
    1610         


<210>  18
<211>  1502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide 1-183 + 387-1705 of SEQ ID NO:8

<400>  18

Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu 
1               5                   10                  15      


Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys 
            20                  25                  30          


Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr 
        35                  40                  45              


Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala 
    50                  55                  60                  


Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro 
65                  70                  75                  80  


Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala 
                85                  90                  95      


Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp 
            100                 105                 110         


Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu 
        115                 120                 125             


Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr 
    130                 135                 140                 


Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala 
145                 150                 155                 160 


Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val 
                165                 170                 175     


Ile Gly Asn Ala Ala Gly Ile Pro Gly Leu Arg Arg Pro Ser Leu Gly 
            180                 185                 190         


Ala Val Glu Arg Gln Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly 
        195                 200                 205             


Ser Arg Ser Phe Ser Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu 
    210                 215                 220                 


Ala Ala Glu Leu Glu Met Thr Arg Gln Val Leu His Ala Gly Ala Arg 
225                 230                 235                 240 


Gln Asp Asp Ala Glu Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly 
                245                 250                 255     


Gln Arg Ala Leu Gln Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu 
            260                 265                 270         


Val His Ala Ile Ala Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr 
        275                 280                 285             


Asn Thr Pro Gln Glu Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu 
    290                 295                 300                 


Gly Glu Ala Ser Ser Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg 
305                 310                 315                 320 


Gly Ser Ser Arg Trp Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met 
                325                 330                 335     


Ala Leu Gly Gly Gly Ile Gly Ala Val Gly Ala Gly Met Ser Leu Thr 
            340                 345                 350         


Asp Asp Ala Pro Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile Ala 
        355                 360                 365             


Leu Gln Leu Thr Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu 
    370                 375                 380                 


Ala Leu Ala Ala Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly 
385                 390                 395                 400 


Ala Ser Ala Gly Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro 
                405                 410                 415     


Met Glu Ile Tyr Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu 
            420                 425                 430         


Asp Lys Leu Ala Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala 
        435                 440                 445             


Leu Leu Ala Gln Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val 
    450                 455                 460                 


Ala Gly Val Ser Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile 
465                 470                 475                 480 


Ala Ala Ala Ala Ser Val Val Gly Ala Pro Val Ala Val Val Thr Ser 
                485                 490                 495     


Leu Leu Thr Gly Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro 
            500                 505                 510         


Ile Ile Glu Lys Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu 
        515                 520                 525             


Gly Gly Pro Gln Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu 
    530                 535                 540                 


Gln Leu Ala Asn Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln 
545                 550                 555                 560 


Ala Gly Trp Asn Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile 
                565                 570                 575     


Ser Lys Ser Ala Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn 
            580                 585                 590         


Leu Lys Ser Ala Asp Val Phe Val Asp Arg Phe Ile Gln Gly Glu Arg 
        595                 600                 605             


Val Ala Gly Gln Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp 
    610                 615                 620                 


Ile Ala Ser Arg Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro 
625                 630                 635                 640 


Leu Ala Ala Pro Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys 
                645                 650                 655     


Ser Glu Phe Thr Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp 
            660                 665                 670         


Arg Ile Arg Asp Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val 
        675                 680                 685             


Val Ser Gln Leu Val Asp Ala Asn Gly Val Leu Lys His Ser Ile Lys 
    690                 695                 700                 


Leu Glu Val Ile Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn Ala 
705                 710                 715                 720 


Ser Arg Ile His Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser Tyr 
                725                 730                 735     


Ala Ala Leu Gly Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly Glu 
            740                 745                 750         


Arg Phe Asn Val Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg Glu 
        755                 760                 765             


Gly Val Ala Thr Gln Lys Thr Ala Tyr Gly Lys Arg Thr Glu Asn Val 
    770                 775                 780                 


Gln Tyr Arg His Val Glu Leu Ala Arg Val Gly Gln Leu Val Glu Val 
785                 790                 795                 800 


Asp Thr Leu Glu His Val Gln His Ile Ile Gly Gly Ala Gly Asn Asp 
                805                 810                 815     


Ser Ile Thr Gly Asn Ala His Asp Asn Phe Leu Ala Gly Gly Ala Gly 
            820                 825                 830         


Asp Asp Arg Leu Asp Gly Gly Ala Gly Asn Asp Thr Leu Val Gly Gly 
        835                 840                 845             


Glu Gly His Asn Thr Val Val Gly Gly Ala Gly Asp Asp Val Phe Leu 
    850                 855                 860                 


Gln Asp Leu Gly Val Trp Ser Asn Gln Leu Asp Gly Gly Ala Gly Val 
865                 870                 875                 880 


Asp Thr Val Lys Tyr Asn Val His Gln Pro Ser Glu Glu Arg Leu Glu 
                885                 890                 895     


Arg Met Gly Asp Thr Gly Ile His Ala Asp Leu Gln Lys Gly Thr Val 
            900                 905                 910         


Glu Lys Trp Pro Ala Leu Asn Leu Phe Ser Val Asp His Val Lys Asn 
        915                 920                 925             


Ile Glu Asn Leu His Gly Ser Ser Leu Asn Asp Ser Ile Ala Gly Asp 
    930                 935                 940                 


Asp Arg Asp Asn Glu Leu Trp Gly Asp Asp Gly Asn Asp Thr Ile His 
945                 950                 955                 960 


Gly Arg Gly Gly Asp Asp Ile Leu Arg Gly Gly Leu Gly Leu Asp Thr 
                965                 970                 975     


Leu Tyr Gly Glu Asp Gly Asn Asp Ile Phe Leu Gln Asp Asp Glu Thr 
            980                 985                 990         


Val Ser Asp Asp Ile Asp Gly Gly  Ala Gly Leu Asp Thr  Val Asp Tyr 
        995                 1000                 1005             


Ser Ala  Met Ile His Ala Gly  Lys Ile Val Ala Pro  His Glu Tyr 
    1010                 1015                 1020             


Gly Phe  Gly Ile Glu Ala Asp  Leu Ser Glu Gly Trp  Val Arg Lys 
    1025                 1030                 1035             


Ala Ala  Arg Arg Gly Met Asp  Tyr Tyr Asp Ser Val  Arg Ser Val 
    1040                 1045                 1050             


Glu Asn  Val Ile Gly Thr Ser  Met Lys Asp Val Leu  Ile Gly Asp 
    1055                 1060                 1065             


Ala Gln  Ala Asn Thr Leu Met  Gly Gln Gly Gly Asp  Asp Thr Val 
    1070                 1075                 1080             


Arg Gly  Gly Asp Gly Asp Asp  Leu Leu Phe Gly Gly  Asp Gly Asn 
    1085                 1090                 1095             


Asp Met  Leu Tyr Gly Asp Ala  Gly Asn Asp Thr Leu  Tyr Gly Gly 
    1100                 1105                 1110             


Leu Gly  Asp Asp Thr Leu Glu  Gly Gly Ala Gly Asn  Asp Trp Phe 
    1115                 1120                 1125             


Gly Gln  Thr Pro Ala Arg Glu  His Asp Val Leu Arg  Gly Gly Ala 
    1130                 1135                 1140             


Gly Val  Asp Thr Val Asp Tyr  Ser Gln Ala Gly Ala  His Ala Gly 
    1145                 1150                 1155             


Val Ala  Thr Gly Arg Ile Gly  Leu Gly Ile Leu Ala  Asp Leu Gly 
    1160                 1165                 1170             


Ala Gly  Arg Val Asp Lys Leu  Gly Glu Ala Gly Ser  Ser Ala Tyr 
    1175                 1180                 1185             


Asp Thr  Val Ser Gly Ile Glu  Asn Val Val Gly Thr  Glu Leu Ala 
    1190                 1195                 1200             


Asp Arg  Ile Thr Gly Asp Ala  Gln Ala Asn Val Leu  Arg Gly Ala 
    1205                 1210                 1215             


Gly Gly  Ala Asp Val Leu Ala  Gly Gly Glu Gly Asp  Asp Val Leu 
    1220                 1225                 1230             


Leu Gly  Gly Asp Gly Asp Asp  Gln Leu Ser Gly Asp  Ala Gly Arg 
    1235                 1240                 1245             


Asp Arg  Leu Tyr Gly Glu Ala  Gly Asp Asp Trp Phe  Phe Gln Asp 
    1250                 1255                 1260             


Ala Ala  Asn Ala Gly Asn Leu  Leu Asp Gly Gly Asp  Gly Asn Asp 
    1265                 1270                 1275             


Thr Val  Asp Phe Ser Gly Pro  Gly Arg Gly Leu Asp  Ala Gly Ala 
    1280                 1285                 1290             


Lys Gly  Val Phe Leu Ser Leu  Gly Lys Gly Phe Ala  Ser Leu Met 
    1295                 1300                 1305             


Asp Glu  Pro Glu Thr Ser Asn  Val Leu Arg His Ile  Glu Asn Ala 
    1310                 1315                 1320             


Val Gly  Ser Val Arg Asp Asp  Val Leu Ile Gly Asp  Ala Gly Ala 
    1325                 1330                 1335             


Asn Val  Leu Asn Gly Leu Ala  Gly Asn Asp Val Leu  Ser Gly Gly 
    1340                 1345                 1350             


Ala Gly  Asp Asp Val Leu Leu  Gly Asp Glu Gly Ser  Asp Leu Leu 
    1355                 1360                 1365             


Ser Gly  Asp Ala Gly Asn Asp  Asp Leu Phe Gly Gly  Gln Gly Asp 
    1370                 1375                 1380             


Asp Thr  Tyr Leu Phe Gly Ala  Gly Tyr Gly His Asp  Thr Ile Tyr 
    1385                 1390                 1395             


Glu Ser  Gly Gly Gly His Asp  Thr Ile Arg Ile Asn  Ala Gly Ala 
    1400                 1405                 1410             


Asp Gln  Leu Trp Phe Ala Arg  Gln Gly Asn Asp Leu  Glu Ile Arg 
    1415                 1420                 1425             


Ile Leu  Gly Thr Asp Asp Ala  Leu Thr Val His Asp  Trp Tyr Arg 
    1430                 1435                 1440             


Asp Ala  Asp His Arg Val Glu  Ala Ile His Ala Ala  Asn Gln Ala 
    1445                 1450                 1455             


Ile Asp  Pro Ala Gly Ile Glu  Lys Leu Val Glu Ala  Met Ala Gln 
    1460                 1465                 1470             


Tyr Pro  Asp Pro Gly Ala Ala  Ala Ala Ala Pro Pro  Ala Ala Arg 
    1475                 1480                 1485             


Val Pro  Asp Thr Leu Met Gln  Ser Leu Ala Val Asn  Trp Arg 
    1490                 1495                 1500         


<210>  19
<211>  1547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide 1-227 + 387-1706 of SEQ ID NO:2

<400>  19

Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu 
1               5                   10                  15      


Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys 
            20                  25                  30          


Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr 
        35                  40                  45              


Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala 
    50                  55                  60                  


Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro 
65                  70                  75                  80  


Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala 
                85                  90                  95      


Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp 
            100                 105                 110         


Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu 
        115                 120                 125             


Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr 
    130                 135                 140                 


Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala 
145                 150                 155                 160 


Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val 
                165                 170                 175     


Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe 
            180                 185                 190         


Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser 
        195                 200                 205             


Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg 
    210                 215                 220                 


Ala Ala Ser Pro Gly Leu Arg Arg Pro Ser Leu Gly Ala Val Glu Arg 
225                 230                 235                 240 


Gln Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly Ser Arg Ser Phe 
                245                 250                 255     


Ser Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu Ala Ala Glu Leu 
            260                 265                 270         


Glu Met Thr Arg Gln Val Leu His Ala Gly Ala Arg Gln Asp Asp Ala 
        275                 280                 285             


Glu Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly Gln Arg Ala Leu 
    290                 295                 300                 


Gln Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu Val His Ala Ile 
305                 310                 315                 320 


Ala Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr Asn Thr Pro Gln 
                325                 330                 335     


Glu Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu Gly Glu Ala Ser 
            340                 345                 350         


Ser Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg Gly Ser Ser Arg 
        355                 360                 365             


Trp Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met Ala Leu Gly Gly 
    370                 375                 380                 


Gly Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu Thr Asp Asp Ala 
385                 390                 395                 400 


Pro Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile Ala Leu Gln Leu 
                405                 410                 415     


Thr Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu Ala Leu Ala 
            420                 425                 430         


Ala Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly Ala Ser Ala 
        435                 440                 445             


Gly Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro Met Glu Ile 
    450                 455                 460                 


Tyr Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu Asp Lys Leu 
465                 470                 475                 480 


Ala Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala Leu Leu Ala 
                485                 490                 495     


Gln Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val Ala Gly Val 
            500                 505                 510         


Ser Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile Ala Ala Ala 
        515                 520                 525             


Ala Ser Val Val Gly Ala Pro Val Ala Val Val Thr Ser Leu Leu Thr 
    530                 535                 540                 


Gly Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro Ile Ile Glu 
545                 550                 555                 560 


Lys Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu Gly Gly Pro 
                565                 570                 575     


Gln Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu Gln Leu Ala 
            580                 585                 590         


Asn Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln Ala Gly Trp 
        595                 600                 605             


Asn Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile Ser Lys Ser 
    610                 615                 620                 


Ala Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn Leu Lys Ser 
625                 630                 635                 640 


Val Asp Val Phe Val Asp Arg Phe Val Gln Gly Glu Arg Val Ala Gly 
                645                 650                 655     


Gln Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp Ile Ala Ser 
            660                 665                 670         


Arg Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro Leu Ala Ala 
        675                 680                 685             


Pro Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys Ser Glu Phe 
    690                 695                 700                 


Thr Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp Arg Ile Arg 
705                 710                 715                 720 


Asp Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val Val Ser Gln 
                725                 730                 735     


Leu Val Asp Ala Asn Gly Val Leu Lys His Ser Ile Lys Leu Asp Val 
            740                 745                 750         


Ile Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn Ala Ser Arg Ile 
        755                 760                 765             


His Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser Tyr Ala Ala Leu 
    770                 775                 780                 


Gly Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly Glu Arg Phe Asn 
785                 790                 795                 800 


Val Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg Glu Gly Val Ala 
                805                 810                 815     


Thr Gln Thr Thr Ala Tyr Gly Lys Arg Thr Glu Asn Val Gln Tyr Arg 
            820                 825                 830         


His Val Glu Leu Ala Arg Val Gly Gln Leu Val Glu Val Asp Thr Leu 
        835                 840                 845             


Glu His Val Gln His Ile Ile Gly Gly Ala Gly Asn Asp Ser Ile Thr 
    850                 855                 860                 


Gly Asn Ala His Asp Asn Phe Leu Ala Gly Gly Ser Gly Asp Asp Arg 
865                 870                 875                 880 


Leu Asp Gly Gly Ala Gly Asn Asp Thr Leu Val Gly Gly Glu Gly Gln 
                885                 890                 895     


Asn Thr Val Ile Gly Gly Ala Gly Asp Asp Val Phe Leu Gln Asp Leu 
            900                 905                 910         


Gly Val Trp Ser Asn Gln Leu Asp Gly Gly Ala Gly Val Asp Thr Val 
        915                 920                 925             


Lys Tyr Asn Val His Gln Pro Ser Glu Glu Arg Leu Glu Arg Met Gly 
    930                 935                 940                 


Asp Thr Gly Ile His Ala Asp Leu Gln Lys Gly Thr Val Glu Lys Trp 
945                 950                 955                 960 


Pro Ala Leu Asn Leu Phe Ser Val Asp His Val Lys Asn Ile Glu Asn 
                965                 970                 975     


Leu His Gly Ser Arg Leu Asn Asp Arg Ile Ala Gly Asp Asp Gln Asp 
            980                 985                 990         


Asn Glu Leu Trp Gly His Asp Gly  Asn Asp Thr Ile Arg  Gly Arg Gly 
        995                 1000                 1005             


Gly Asp  Asp Ile Leu Arg Gly  Gly Leu Gly Leu Asp  Thr Leu Tyr 
    1010                 1015                 1020             


Gly Glu  Asp Gly Asn Asp Ile  Phe Leu Gln Asp Asp  Glu Thr Val 
    1025                 1030                 1035             


Ser Asp  Asp Ile Asp Gly Gly  Ala Gly Leu Asp Thr  Val Asp Tyr 
    1040                 1045                 1050             


Ser Ala  Met Ile His Pro Gly  Arg Ile Val Ala Pro  His Glu Tyr 
    1055                 1060                 1065             


Gly Phe  Gly Ile Glu Ala Asp  Leu Ser Arg Glu Trp  Val Arg Lys 
    1070                 1075                 1080             


Ala Ser  Ala Leu Gly Val Asp  Tyr Tyr Asp Asn Val  Arg Asn Val 
    1085                 1090                 1095             


Glu Asn  Val Ile Gly Thr Ser  Met Lys Asp Val Leu  Ile Gly Asp 
    1100                 1105                 1110             


Ala Gln  Ala Asn Thr Leu Met  Gly Gln Gly Gly Asp  Asp Thr Val 
    1115                 1120                 1125             


Arg Gly  Gly Asp Gly Asp Asp  Leu Leu Phe Gly Gly  Asp Gly Asn 
    1130                 1135                 1140             


Asp Met  Leu Tyr Gly Asp Ala  Gly Asn Asp Thr Leu  Tyr Gly Gly 
    1145                 1150                 1155             


Leu Gly  Asp Asp Thr Leu Glu  Gly Gly Ala Gly Asn  Asp Trp Phe 
    1160                 1165                 1170             


Gly Gln  Thr Gln Ala Arg Glu  His Asp Val Leu Arg  Gly Gly Asp 
    1175                 1180                 1185             


Gly Val  Asp Thr Val Asp Tyr  Ser Gln Thr Gly Ala  His Ala Gly 
    1190                 1195                 1200             


Ile Ala  Ala Gly Arg Ile Gly  Leu Gly Ile Leu Ala  Asp Leu Gly 
    1205                 1210                 1215             


Ala Gly  Arg Val Asp Lys Leu  Gly Glu Ala Gly Ser  Ser Ala Tyr 
    1220                 1225                 1230             


Asp Thr  Val Ser Gly Ile Glu  Asn Val Val Gly Thr  Glu Leu Ala 
    1235                 1240                 1245             


Asp Arg  Ile Thr Gly Asp Ala  Gln Ala Asn Val Leu  Arg Gly Ala 
    1250                 1255                 1260             


Gly Gly  Ala Asp Val Leu Ala  Gly Gly Glu Gly Asp  Asp Val Leu 
    1265                 1270                 1275             


Leu Gly  Gly Asp Gly Asp Asp  Gln Leu Ser Gly Asp  Ala Gly Arg 
    1280                 1285                 1290             


Asp Arg  Leu Tyr Gly Glu Ala  Gly Asp Asp Trp Phe  Phe Gln Asp 
    1295                 1300                 1305             


Ala Ala  Asn Ala Gly Asn Leu  Leu Asp Gly Gly Asp  Gly Arg Asp 
    1310                 1315                 1320             


Thr Val  Asp Phe Ser Gly Pro  Gly Arg Gly Leu Asp  Ala Gly Ala 
    1325                 1330                 1335             


Lys Gly  Val Phe Leu Ser Leu  Gly Lys Gly Phe Ala  Ser Leu Met 
    1340                 1345                 1350             


Asp Glu  Pro Glu Thr Ser Asn  Val Leu Arg Asn Ile  Glu Asn Ala 
    1355                 1360                 1365             


Val Gly  Ser Ala Arg Asp Asp  Val Leu Ile Gly Asp  Ala Gly Ala 
    1370                 1375                 1380             


Asn Val  Leu Asn Gly Leu Ala  Gly Asn Asp Val Leu  Ser Gly Gly 
    1385                 1390                 1395             


Ala Gly  Asp Asp Val Leu Leu  Gly Asp Glu Gly Ser  Asp Leu Leu 
    1400                 1405                 1410             


Ser Gly  Asp Ala Gly Asn Asp  Asp Leu Phe Gly Gly  Gln Gly Asp 
    1415                 1420                 1425             


Asp Thr  Tyr Leu Phe Gly Val  Gly Tyr Gly His Asp  Thr Ile Tyr 
    1430                 1435                 1440             


Glu Ser  Gly Gly Gly His Asp  Thr Ile Arg Ile Asn  Ala Gly Ala 
    1445                 1450                 1455             


Asp Gln  Leu Trp Phe Ala Arg  Gln Gly Asn Asp Leu  Glu Ile Arg 
    1460                 1465                 1470             


Ile Leu  Gly Thr Asp Asp Ala  Leu Thr Val His Asp  Trp Tyr Arg 
    1475                 1480                 1485             


Asp Ala  Asp His Arg Val Glu  Ile Ile His Ala Ala  Asn Gln Ala 
    1490                 1495                 1500             


Val Asp  Gln Ala Gly Ile Glu  Lys Leu Val Glu Ala  Met Ala Gln 
    1505                 1510                 1515             


Tyr Pro  Asp Pro Gly Ala Ala  Ala Ala Ala Pro Pro  Ala Ala Arg 
    1520                 1525                 1530             


Val Pro  Asp Thr Leu Met Gln  Ser Leu Ala Val Asn  Trp Arg 
    1535                 1540                 1545         


<210>  20
<211>  1569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide 1-183 + 321-1706 of SEQ ID NO:2

<400>  20

Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu 
1               5                   10                  15      


Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys 
            20                  25                  30          


Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr 
        35                  40                  45              


Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala 
    50                  55                  60                  


Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro 
65                  70                  75                  80  


Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala 
                85                  90                  95      


Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp 
            100                 105                 110         


Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu 
        115                 120                 125             


Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr 
    130                 135                 140                 


Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala 
145                 150                 155                 160 


Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val 
                165                 170                 175     


Ile Gly Asn Ala Ala Gly Ile Glu Ser Gln Met Leu Thr Arg Gly Gln 
            180                 185                 190         


Leu Lys Glu Tyr Ile Gly Gln Gln Arg Gly Glu Gly Tyr Val Phe Tyr 
        195                 200                 205             


Glu Asn Arg Ala Tyr Gly Val Ala Gly Lys Ser Leu Phe Asp Asp Gly 
    210                 215                 220                 


Leu Gly Ala Ala Pro Gly Val Pro Ser Gly Arg Ser Lys Phe Ser Pro 
225                 230                 235                 240 


Asp Val Leu Glu Thr Val Pro Ala Ser Pro Gly Leu Arg Arg Pro Ser 
                245                 250                 255     


Leu Gly Ala Val Glu Arg Gln Asp Ser Gly Tyr Asp Ser Leu Asp Gly 
            260                 265                 270         


Val Gly Ser Arg Ser Phe Ser Leu Gly Glu Val Ser Asp Met Ala Ala 
        275                 280                 285             


Val Glu Ala Ala Glu Leu Glu Met Thr Arg Gln Val Leu His Ala Gly 
    290                 295                 300                 


Ala Arg Gln Asp Asp Ala Glu Pro Gly Val Ser Gly Ala Ser Ala His 
305                 310                 315                 320 


Trp Gly Gln Arg Ala Leu Gln Gly Ala Gln Ala Val Ala Ala Ala Gln 
                325                 330                 335     


Arg Leu Val His Ala Ile Ala Leu Met Thr Gln Phe Gly Arg Ala Gly 
            340                 345                 350         


Ser Thr Asn Thr Pro Gln Glu Ala Ala Ser Leu Ser Ala Ala Val Phe 
        355                 360                 365             


Gly Leu Gly Glu Ala Ser Ser Ala Val Ala Glu Thr Val Ser Gly Phe 
    370                 375                 380                 


Phe Arg Gly Ser Ser Arg Trp Ala Gly Gly Phe Gly Val Ala Gly Gly 
385                 390                 395                 400 


Ala Met Ala Leu Gly Gly Gly Ile Ala Ala Ala Val Gly Ala Gly Met 
                405                 410                 415     


Ser Leu Thr Asp Asp Ala Pro Ala Gly Gln Lys Ala Ala Ala Gly Ala 
            420                 425                 430         


Glu Ile Ala Leu Gln Leu Thr Gly Gly Thr Val Glu Leu Ala Ser Ser 
        435                 440                 445             


Ile Ala Leu Ala Leu Ala Ala Ala Arg Gly Val Thr Ser Gly Leu Gln 
    450                 455                 460                 


Val Ala Gly Ala Ser Ala Gly Ala Ala Ala Gly Ala Leu Ala Ala Ala 
465                 470                 475                 480 


Leu Ser Pro Met Glu Ile Tyr Gly Leu Val Gln Gln Ser His Tyr Ala 
                485                 490                 495     


Asp Gln Leu Asp Lys Leu Ala Gln Glu Ser Ser Ala Tyr Gly Tyr Glu 
            500                 505                 510         


Gly Asp Ala Leu Leu Ala Gln Leu Tyr Arg Asp Lys Thr Ala Ala Glu 
        515                 520                 525             


Gly Ala Val Ala Gly Val Ser Ala Val Leu Ser Thr Val Gly Ala Ala 
    530                 535                 540                 


Val Ser Ile Ala Ala Ala Ala Ser Val Val Gly Ala Pro Val Ala Val 
545                 550                 555                 560 


Val Thr Ser Leu Leu Thr Gly Ala Leu Asn Gly Ile Leu Arg Gly Val 
                565                 570                 575     


Gln Gln Pro Ile Ile Glu Lys Leu Ala Asn Asp Tyr Ala Arg Lys Ile 
            580                 585                 590         


Asp Glu Leu Gly Gly Pro Gln Ala Tyr Phe Glu Lys Asn Leu Gln Ala 
        595                 600                 605             


Arg His Glu Gln Leu Ala Asn Ser Asp Gly Leu Arg Lys Met Leu Ala 
    610                 615                 620                 


Asp Leu Gln Ala Gly Trp Asn Ala Ser Ser Val Ile Gly Val Gln Thr 
625                 630                 635                 640 


Thr Glu Ile Ser Lys Ser Ala Leu Glu Leu Ala Ala Ile Thr Gly Asn 
                645                 650                 655     


Ala Asp Asn Leu Lys Ser Val Asp Val Phe Val Asp Arg Phe Val Gln 
            660                 665                 670         


Gly Glu Arg Val Ala Gly Gln Pro Val Val Leu Asp Val Ala Ala Gly 
        675                 680                 685             


Gly Ile Asp Ile Ala Ser Arg Lys Gly Glu Arg Pro Ala Leu Thr Phe 
    690                 695                 700                 


Ile Thr Pro Leu Ala Ala Pro Gly Glu Glu Gln Arg Arg Arg Thr Lys 
705                 710                 715                 720 


Thr Gly Lys Ser Glu Phe Thr Thr Phe Val Glu Ile Val Gly Lys Gln 
                725                 730                 735     


Asp Arg Trp Arg Ile Arg Asp Gly Ala Ala Asp Thr Thr Ile Asp Leu 
            740                 745                 750         


Ala Lys Val Val Ser Gln Leu Val Asp Ala Asn Gly Val Leu Lys His 
        755                 760                 765             


Ser Ile Lys Leu Asp Val Ile Gly Gly Asp Gly Asp Asp Val Val Leu 
    770                 775                 780                 


Ala Asn Ala Ser Arg Ile His Tyr Asp Gly Gly Ala Gly Thr Asn Thr 
785                 790                 795                 800 


Val Ser Tyr Ala Ala Leu Gly Arg Gln Asp Ser Ile Thr Val Ser Ala 
                805                 810                 815     


Asp Gly Glu Arg Phe Asn Val Arg Lys Gln Leu Asn Asn Ala Asn Val 
            820                 825                 830         


Tyr Arg Glu Gly Val Ala Thr Gln Thr Thr Ala Tyr Gly Lys Arg Thr 
        835                 840                 845             


Glu Asn Val Gln Tyr Arg His Val Glu Leu Ala Arg Val Gly Gln Leu 
    850                 855                 860                 


Val Glu Val Asp Thr Leu Glu His Val Gln His Ile Ile Gly Gly Ala 
865                 870                 875                 880 


Gly Asn Asp Ser Ile Thr Gly Asn Ala His Asp Asn Phe Leu Ala Gly 
                885                 890                 895     


Gly Ser Gly Asp Asp Arg Leu Asp Gly Gly Ala Gly Asn Asp Thr Leu 
            900                 905                 910         


Val Gly Gly Glu Gly Gln Asn Thr Val Ile Gly Gly Ala Gly Asp Asp 
        915                 920                 925             


Val Phe Leu Gln Asp Leu Gly Val Trp Ser Asn Gln Leu Asp Gly Gly 
    930                 935                 940                 


Ala Gly Val Asp Thr Val Lys Tyr Asn Val His Gln Pro Ser Glu Glu 
945                 950                 955                 960 


Arg Leu Glu Arg Met Gly Asp Thr Gly Ile His Ala Asp Leu Gln Lys 
                965                 970                 975     


Gly Thr Val Glu Lys Trp Pro Ala Leu Asn Leu Phe Ser Val Asp His 
            980                 985                 990         


Val Lys Asn Ile Glu Asn Leu His  Gly Ser Arg Leu Asn  Asp Arg Ile 
        995                 1000                 1005             


Ala Gly  Asp Asp Gln Asp Asn  Glu Leu Trp Gly His  Asp Gly Asn 
    1010                 1015                 1020             


Asp Thr  Ile Arg Gly Arg Gly  Gly Asp Asp Ile Leu  Arg Gly Gly 
    1025                 1030                 1035             


Leu Gly  Leu Asp Thr Leu Tyr  Gly Glu Asp Gly Asn  Asp Ile Phe 
    1040                 1045                 1050             


Leu Gln  Asp Asp Glu Thr Val  Ser Asp Asp Ile Asp  Gly Gly Ala 
    1055                 1060                 1065             


Gly Leu  Asp Thr Val Asp Tyr  Ser Ala Met Ile His  Pro Gly Arg 
    1070                 1075                 1080             


Ile Val  Ala Pro His Glu Tyr  Gly Phe Gly Ile Glu  Ala Asp Leu 
    1085                 1090                 1095             


Ser Arg  Glu Trp Val Arg Lys  Ala Ser Ala Leu Gly  Val Asp Tyr 
    1100                 1105                 1110             


Tyr Asp  Asn Val Arg Asn Val  Glu Asn Val Ile Gly  Thr Ser Met 
    1115                 1120                 1125             


Lys Asp  Val Leu Ile Gly Asp  Ala Gln Ala Asn Thr  Leu Met Gly 
    1130                 1135                 1140             


Gln Gly  Gly Asp Asp Thr Val  Arg Gly Gly Asp Gly  Asp Asp Leu 
    1145                 1150                 1155             


Leu Phe  Gly Gly Asp Gly Asn  Asp Met Leu Tyr Gly  Asp Ala Gly 
    1160                 1165                 1170             


Asn Asp  Thr Leu Tyr Gly Gly  Leu Gly Asp Asp Thr  Leu Glu Gly 
    1175                 1180                 1185             


Gly Ala  Gly Asn Asp Trp Phe  Gly Gln Thr Gln Ala  Arg Glu His 
    1190                 1195                 1200             


Asp Val  Leu Arg Gly Gly Asp  Gly Val Asp Thr Val  Asp Tyr Ser 
    1205                 1210                 1215             


Gln Thr  Gly Ala His Ala Gly  Ile Ala Ala Gly Arg  Ile Gly Leu 
    1220                 1225                 1230             


Gly Ile  Leu Ala Asp Leu Gly  Ala Gly Arg Val Asp  Lys Leu Gly 
    1235                 1240                 1245             


Glu Ala  Gly Ser Ser Ala Tyr  Asp Thr Val Ser Gly  Ile Glu Asn 
    1250                 1255                 1260             


Val Val  Gly Thr Glu Leu Ala  Asp Arg Ile Thr Gly  Asp Ala Gln 
    1265                 1270                 1275             


Ala Asn  Val Leu Arg Gly Ala  Gly Gly Ala Asp Val  Leu Ala Gly 
    1280                 1285                 1290             


Gly Glu  Gly Asp Asp Val Leu  Leu Gly Gly Asp Gly  Asp Asp Gln 
    1295                 1300                 1305             


Leu Ser  Gly Asp Ala Gly Arg  Asp Arg Leu Tyr Gly  Glu Ala Gly 
    1310                 1315                 1320             


Asp Asp  Trp Phe Phe Gln Asp  Ala Ala Asn Ala Gly  Asn Leu Leu 
    1325                 1330                 1335             


Asp Gly  Gly Asp Gly Arg Asp  Thr Val Asp Phe Ser  Gly Pro Gly 
    1340                 1345                 1350             


Arg Gly  Leu Asp Ala Gly Ala  Lys Gly Val Phe Leu  Ser Leu Gly 
    1355                 1360                 1365             


Lys Gly  Phe Ala Ser Leu Met  Asp Glu Pro Glu Thr  Ser Asn Val 
    1370                 1375                 1380             


Leu Arg  Asn Ile Glu Asn Ala  Val Gly Ser Ala Arg  Asp Asp Val 
    1385                 1390                 1395             


Leu Ile  Gly Asp Ala Gly Ala  Asn Val Leu Asn Gly  Leu Ala Gly 
    1400                 1405                 1410             


Asn Asp  Val Leu Ser Gly Gly  Ala Gly Asp Asp Val  Leu Leu Gly 
    1415                 1420                 1425             


Asp Glu  Gly Ser Asp Leu Leu  Ser Gly Asp Ala Gly  Asn Asp Asp 
    1430                 1435                 1440             


Leu Phe  Gly Gly Gln Gly Asp  Asp Thr Tyr Leu Phe  Gly Val Gly 
    1445                 1450                 1455             


Tyr Gly  His Asp Thr Ile Tyr  Glu Ser Gly Gly Gly  His Asp Thr 
    1460                 1465                 1470             


Ile Arg  Ile Asn Ala Gly Ala  Asp Gln Leu Trp Phe  Ala Arg Gln 
    1475                 1480                 1485             


Gly Asn  Asp Leu Glu Ile Arg  Ile Leu Gly Thr Asp  Asp Ala Leu 
    1490                 1495                 1500             


Thr Val  His Asp Trp Tyr Arg  Asp Ala Asp His Arg  Val Glu Ile 
    1505                 1510                 1515             


Ile His  Ala Ala Asn Gln Ala  Val Asp Gln Ala Gly  Ile Glu Lys 
    1520                 1525                 1530             


Leu Val  Glu Ala Met Ala Gln  Tyr Pro Asp Pro Gly  Ala Ala Ala 
    1535                 1540                 1545             


Ala Ala  Pro Pro Ala Ala Arg  Val Pro Asp Thr Leu  Met Gln Ser 
    1550                 1555                 1560             


Leu Ala  Val Asn Trp Arg 
    1565                 


<210>  21
<211>  558
<212>  DNA
<213>  Bordetella pertussis

<400>  21
atgcttccgt ccgcccaagc gccctccctc ctcaatccca ccgacgactt cgcggcactg       60

ggcaatattg cctggctgtg gatgaactct cccatgcacc gcgactggcc ggtgcatctg      120

ctcgcacgca acacgctcgc gccgattcaa ctgggccaat acattctgct gcgatgcaat      180

gacgtgccgg ttgcatactg cagctgggcc ctaatggacg ccgacaccga actctcctat      240

gtcatggcgc cctcgtcgct gggcgggaat gcctggaact gcggcgaccg actgtggatc      300

atcgactgga tcgcgccatt ctcgcgcgac gacaatcgtg cgctgcgccg cgcgctggcc      360

gaacggcacc ccgacagcgt gggccgttcg ctgcgcgttc ggcgcggcgg cgacaccgcg      420

cgcgtcaagg agtaccgagg ccgcgcgctg gacgcggccg ccgctcgcgc gcagctggac      480

cgctaccatg ccgaactgat cgcaggactg cgcgcgagca acggcggata cgcgccgcga      540

ggccggggca ccgcctga                                                    558


<210>  22
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimized version of CyaC nucleotide coding sequence


<220>
<221>  CDS
<222>  (1)..(558)

<400>  22
atg ctg ccg tct gca cag gcg ccg tct ctg ctg aat cca act gat gac         48
Met Leu Pro Ser Ala Gln Ala Pro Ser Leu Leu Asn Pro Thr Asp Asp           
1               5                   10                  15                

ttc gct gcg ctg ggt aac atc gcg tgg ctg tgg atg aac agc ccg atg         96
Phe Ala Ala Leu Gly Asn Ile Ala Trp Leu Trp Met Asn Ser Pro Met           
            20                  25                  30                    

cac cgt gac tgg ccg gtt cac ctg ctg gca cgt aac acg ctg gcg ccg        144
His Arg Asp Trp Pro Val His Leu Leu Ala Arg Asn Thr Leu Ala Pro           
        35                  40                  45                        

atc cag ctg ggt caa tac atc ctg ctg cgt tgt aac gac gtg cct gtg        192
Ile Gln Leu Gly Gln Tyr Ile Leu Leu Arg Cys Asn Asp Val Pro Val           
    50                  55                  60                            

gcg tat tgc tcc tgg gca ctg atg gat gcg gat acc gag ctg tcc tac        240
Ala Tyr Cys Ser Trp Ala Leu Met Asp Ala Asp Thr Glu Leu Ser Tyr           
65                  70                  75                  80            

gtt atg gcc cca tct agc ctg ggc ggt aac gct tgg aac tgc ggc gat        288
Val Met Ala Pro Ser Ser Leu Gly Gly Asn Ala Trp Asn Cys Gly Asp           
                85                  90                  95                

cgt ctg tgg atc att gat tgg att gct ccg ttt agc cgt gac gac aac        336
Arg Leu Trp Ile Ile Asp Trp Ile Ala Pro Phe Ser Arg Asp Asp Asn           
            100                 105                 110                   

cgt gct ctg cgt cgc gcg ctg gcc gaa cgt cat ccg gat tct gtt ggc        384
Arg Ala Leu Arg Arg Ala Leu Ala Glu Arg His Pro Asp Ser Val Gly           
        115                 120                 125                       

cgt tcc ctg cgc gta cgt cgc ggt ggc gac acc gct cgc gtc aaa gaa        432
Arg Ser Leu Arg Val Arg Arg Gly Gly Asp Thr Ala Arg Val Lys Glu           
    130                 135                 140                           

tac cgt ggt cgt gct ctg gac gca gcg gcg gcc cgc gct cag ctg gac        480
Tyr Arg Gly Arg Ala Leu Asp Ala Ala Ala Ala Arg Ala Gln Leu Asp           
145                 150                 155                 160           

cgc tac cac gca gaa ctg att gcc ggt ctg cgt gca tcc aat ggc ggt        528
Arg Tyr His Ala Glu Leu Ile Ala Gly Leu Arg Ala Ser Asn Gly Gly           
                165                 170                 175               

tat gct ccg cgt ggc cgt ggc acc gca taa                                558
Tyr Ala Pro Arg Gly Arg Gly Thr Ala                                       
            180                 185                                       


<210>  23
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

Met Leu Pro Ser Ala Gln Ala Pro Ser Leu Leu Asn Pro Thr Asp Asp 
1               5                   10                  15      


Phe Ala Ala Leu Gly Asn Ile Ala Trp Leu Trp Met Asn Ser Pro Met 
            20                  25                  30          


His Arg Asp Trp Pro Val His Leu Leu Ala Arg Asn Thr Leu Ala Pro 
        35                  40                  45              


Ile Gln Leu Gly Gln Tyr Ile Leu Leu Arg Cys Asn Asp Val Pro Val 
    50                  55                  60                  


Ala Tyr Cys Ser Trp Ala Leu Met Asp Ala Asp Thr Glu Leu Ser Tyr 
65                  70                  75                  80  


Val Met Ala Pro Ser Ser Leu Gly Gly Asn Ala Trp Asn Cys Gly Asp 
                85                  90                  95      


Arg Leu Trp Ile Ile Asp Trp Ile Ala Pro Phe Ser Arg Asp Asp Asn 
            100                 105                 110         


Arg Ala Leu Arg Arg Ala Leu Ala Glu Arg His Pro Asp Ser Val Gly 
        115                 120                 125             


Arg Ser Leu Arg Val Arg Arg Gly Gly Asp Thr Ala Arg Val Lys Glu 
    130                 135                 140                 


Tyr Arg Gly Arg Ala Leu Asp Ala Ala Ala Ala Arg Ala Gln Leu Asp 
145                 150                 155                 160 


Arg Tyr His Ala Glu Leu Ile Ala Gly Leu Arg Ala Ser Asn Gly Gly 
                165                 170                 175     


Tyr Ala Pro Arg Gly Arg Gly Thr Ala 
            180                 185 


<210>  24
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Model antigen (peptide 105)

<400>  24

Met Gly Ile Arg Ser Arg Asp His Met Val Leu His Glu Tyr Val Asn 
1               5                   10                  15      


Ala Ala Gly Ile Thr Gly Ser Asp Arg Met Glu Val Gly Trp Tyr Arg 
            20                  25                  30          


Ser Pro Phe Ser Arg Val Val His Leu Tyr Arg Asn Gly Lys Ser Ile 
        35                  40                  45              


Ile Asn Phe Glu Lys Leu Val Arg Val Asp Met Val Arg His Arg Ile 
    50                  55                  60                  


Lys Glu His Met Leu Lys Lys Tyr Thr Gln Ile Tyr Ser Thr Val Ala 
65                  70                  75                  80  


Ser Ser Leu Ser Gly Glu Lys Ile Ser Gln Ala Val His Ala Ala His 
                85                  90                  95      


Ala Glu Ile Asn Glu Ala Gly Arg Glu Leu Ala Gly Ile Gly Ile Leu 
            100                 105                 110         


Thr Val Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Lys 
        115                 120                 125             


Ala Val Tyr Asn Phe Ala Thr Cys Ser Gly Arg Lys Val Ala Glu Leu 
    130                 135                 140                 


Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu Pro Val Thr Lys 
145                 150                 155                 160 


Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln Tyr Phe Phe Pro 
                165                 170                 175     


Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu Val Phe Gly Ile 
            180                 185                 190         


Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr Ile Phe Ala Thr 
        195                 200                 205             


Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu Glu Tyr Arg 
    210                 215                 220                 


Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu Trp Gly Pro 
225                 230                 235                 240 


Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Thr Gly Met His Gly Asp 
                245                 250                 255     


Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr 
            260                 265                 270         


Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Gly Pro Ala Gly Gln Ala Glu 
        275                 280                 285             


Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp 
    290                 295                 300                 


Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr 
305                 310                 315                 320 


Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys 
                325                 330                 335     


Ser Gln Lys Pro Met His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val 
            340                 345                 350         


Leu His Leu Glu Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His 
        355                 360                 365             


Glu Gln Leu Ser Ala Ser Gly Val Asn His Gln His Leu Pro Ala Arg 
    370                 375                 380                 


Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met Cys Cys Lys Cys 
385                 390                 395                 400 


Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg 
                405                 410                 415     


Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe Val Cys Pro Trp 
            420                 425                 430         


Cys Ala Ser Gln Gln Leu Lys Gly Pro 
        435                 440     


<210>  25
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of E7 of HPV16

<400>  25

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  26
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of E7 of HPV18

<400>  26

Met His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu 
1               5                   10                  15      


Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser 
            20                  25                  30          


Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His 
        35                  40                  45              


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met 
    50                  55                  60                  


Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala 
65                  70                  75                  80  


Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe 
                85                  90                  95      


Val Cys Pro Trp Cys Ala Ser Gln Gln 
            100                 105 


<210>  27
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of E7 of HPV31

<400>  27

Met Arg Gly Glu Thr Pro Thr Leu Gln Asp Tyr Val Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Ala Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Pro Asp Ser Ser 
            20                  25                  30          


Asp Glu Glu Asp Val Ile Asp Ser Pro Ala Gly Gln Ala Lys Pro Asp 
        35                  40                  45              


Thr Ser Asn Tyr Asn Ile Val Thr Phe Cys Cys Gln Cys Glu Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr Gln Val Asp Ile Arg Ile Leu Gln 
65                  70                  75                  80  


Glu Leu Leu Met Gly Ser Phe Gly Ile Val Cys Pro Asn Cys Ser Thr 
                85                  90                  95      


Arg Leu 
        


<210>  28
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of E7 of HPV33

<400>  28

Met Arg Gly His Lys Pro Thr Leu Lys Glu Tyr Ile Leu Asp Leu Tyr 
1               5                   10                  15      


Pro Glu Pro Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Ser Asp Ser Ser 
            20                  25                  30          


Asp Glu Asp Glu Gly Leu Asp Arg Pro Asp Gly Gln Ala Gln Pro Ala 
        35                  40                  45              


Thr Ala Asp Tyr Tyr Ile Val Thr Cys Cys His Thr Cys Asn Thr Thr 
    50                  55                  60                  


Val Arg Leu Cys Val Asn Ser Thr Ala Ser Asp Leu Arg Thr Ile Gln 
65                  70                  75                  80  


Gln Leu Leu Met Gly Thr Val Asn Ile Val Cys Pro Ser Cys Ala Gln 
                85                  90                  95      


Leu 
    


<210>  29
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of E7 of HPV45

<400>  29

Met His Gly Pro Arg Glu Thr Leu Gln Glu Ile Val Leu His Leu Glu 
1               5                   10                  15      


Pro Gln Asn Glu Leu Asp Pro Val Asp Leu Leu Cys Tyr Glu Gln Leu 
            20                  25                  30          


Ser Glu Ser Glu Glu Glu Asn Asp Glu Ala Asp Gly Val Ser His Ala 
        35                  40                  45              


Gln Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys 
    50                  55                  60                  


Val Cys Cys Lys Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser 
65                  70                  75                  80  


Ala Glu Asp Leu Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser 
                85                  90                  95      


Phe Val Cys Pro Trp Cys Ala Thr Asn Gln 
            100                 105     


<210>  30
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of E7 of HPV52

<400>  30

Met Arg Gly Asp Lys Ala Thr Ile Lys Asp Tyr Ile Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu His Cys Tyr Glu Gln Leu Gly Asp Ser Ser 
            20                  25                  30          


Asp Glu Glu Asp Thr Asp Gly Val Asp Arg Pro Asp Gly Gln Ala Glu 
        35                  40                  45              


Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr Cys His Ser Cys Asp 
    50                  55                  60                  


Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala Thr Asp Leu Arg Thr 
65                  70                  75                  80  


Leu Gln Gln Met Leu Leu Gly Thr Leu Gln Val Val Cys Pro Gly Cys 
                85                  90                  95      


Ala Arg Leu 
            


<210>  31
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified version of protein sequence of E7 of HPV52

<400>  31

Met Arg Gly Asp Lys Ala Thr Ile Lys Asp Tyr Ile Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu His Cys Tyr Glu Gln Leu Gly Asp Ser Ser 
            20                  25                  30          


Asp Glu Glu Asp Thr Asp Gly Val Asp Arg Pro Asp Gly Gln Ala Glu 
        35                  40                  45              


Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr Cys His Ser Cys Asp 
    50                  55                  60                  


Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala Thr Asp Leu Arg Thr 
65                  70                  75                  80  


Leu Gln Gln Leu Leu Met Gly Thr Leu Gln Val Val Cys Pro Gly Cys 
                85                  90                  95      


Ala Arg Leu 
            


<210>  32
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of E7 of HPV 58

<400>  32

Met Arg Gly Asn Asn Pro Thr Leu Arg Glu Tyr Ile Leu Asp Leu His 
1               5                   10                  15      


Pro Glu Pro Thr Asp Leu Phe Cys Tyr Glu Gln Leu Cys Asp Ser Ser 
            20                  25                  30          


Asp Glu Asp Glu Ile Gly Leu Asp Arg Pro Asp Gly Gln Ala Gln Pro 
        35                  40                  45              


Ala Thr Ala Asn Tyr Tyr Ile Val Thr Cys Cys Tyr Thr Cys Asp Thr 
    50                  55                  60                  


Thr Val Arg Leu Cys Ile Asn Ser Thr Thr Thr Asp Val Arg Thr Leu 
65                  70                  75                  80  


Gln Gln Leu Leu Met Gly Thr Cys Thr Ile Val Cys Pro Ser Cys Ala 
                85                  90                  95      


Gln Gln 
        


<210>  33
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide for antigen E7 of HPV16, HVP18 and HPV45 
       acidic-deleted


<220>
<221>  CDS
<222>  (1)..(828)

<400>  33
ggt cag gcg gaa ccg gat cgc gcg cac tac aac atc gtt act ttt tgt         48
Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys           
1               5                   10                  15                

tgc aaa tgt gat tcc act ctg cgc ctg tgt gtg caa tcc acc cac gta         96
Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val           
            20                  25                  30                    

gac att cgc act ctg gaa gac ctg ctg atg ggt acc ctt ggt att gtt        144
Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val           
        35                  40                  45                        

tgt ccg att tgc tcc cag aag ccg gcg tct ggc gtt aac cac caa cac        192
Cys Pro Ile Cys Ser Gln Lys Pro Ala Ser Gly Val Asn His Gln His           
    50                  55                  60                            

ctg ccg gcg cgt cgc gca gag ccg cag cgt cac acc atg ctg tgc atg        240
Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met           
65                  70                  75                  80            

tgc tgt aaa tgt gag gcc cgt atc gag ctg gtc gtt gag tct agc gcc        288
Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala           
                85                  90                  95                

gac gat ctg cgt gcg ttt cag cag ctg ttc ctg aac acg ctg agc ttc        336
Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe           
            100                 105                 110                   

gtt tgc ccg tgg tgt gct agc cag cag ggc gtg tct cac gct cag ctg        384
Val Cys Pro Trp Cys Ala Ser Gln Gln Gly Val Ser His Ala Gln Leu           
        115                 120                 125                       

ccg gca cgt cgt gct gag cct cag cgt cac aaa atc ctg tgc gtg tgc        432
Pro Ala Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys Val Cys           
    130                 135                 140                           

tgc aaa tgc gat ggc cgc atc gaa ctg acc gtg gaa tct agc gca gaa        480
Cys Lys Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser Ala Glu           
145                 150                 155                 160           

gac ctg cgt acg ctg cag caa ctg ttc ctg agc acg ctg tcc ttc gta        528
Asp Leu Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe Val           
                165                 170                 175               

tgc cct tgg tgc gca act aat cag atg cac ggt gac acc ccg acc ctg        576
Cys Pro Trp Cys Ala Thr Asn Gln Met His Gly Asp Thr Pro Thr Leu           
            180                 185                 190                   

cac gaa tac atg ctg gac ctg cag cca gaa acc acc gat ctg tac tgt        624
His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Cys           
        195                 200                 205                       

tac gaa cag ctg aac atg cat ggc cca aaa gct act ctg cag gat atc        672
Tyr Glu Gln Leu Asn Met His Gly Pro Lys Ala Thr Leu Gln Asp Ile           
    210                 215                 220                           

gtc ctg cat ctg gaa cca cag aac gaa atc ccg gta gat ctg ctg tgc        720
Val Leu His Leu Glu Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys           
225                 230                 235                 240           

cat gag cag ctg atg cat ggt ccg cgt gaa acc ctg cag gaa atc gtt        768
His Glu Gln Leu Met His Gly Pro Arg Glu Thr Leu Gln Glu Ile Val           
                245                 250                 255               

ctg cac ctg gaa ccg caa aac gaa ctg gac ccg gtt gac ctg ctg tgc        816
Leu His Leu Glu Pro Gln Asn Glu Leu Asp Pro Val Asp Leu Leu Cys           
            260                 265                 270                   

tat gaa cag ctg                                                        828
Tyr Glu Gln Leu                                                           
        275                                                               


<210>  34
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34

Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys 
1               5                   10                  15      


Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val 
            20                  25                  30          


Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val 
        35                  40                  45              


Cys Pro Ile Cys Ser Gln Lys Pro Ala Ser Gly Val Asn His Gln His 
    50                  55                  60                  


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met 
65                  70                  75                  80  


Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala 
                85                  90                  95      


Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe 
            100                 105                 110         


Val Cys Pro Trp Cys Ala Ser Gln Gln Gly Val Ser His Ala Gln Leu 
        115                 120                 125             


Pro Ala Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys Val Cys 
    130                 135                 140                 


Cys Lys Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser Ala Glu 
145                 150                 155                 160 


Asp Leu Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe Val 
                165                 170                 175     


Cys Pro Trp Cys Ala Thr Asn Gln Met His Gly Asp Thr Pro Thr Leu 
            180                 185                 190         


His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Cys 
        195                 200                 205             


Tyr Glu Gln Leu Asn Met His Gly Pro Lys Ala Thr Leu Gln Asp Ile 
    210                 215                 220                 


Val Leu His Leu Glu Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys 
225                 230                 235                 240 


His Glu Gln Leu Met His Gly Pro Arg Glu Thr Leu Gln Glu Ile Val 
                245                 250                 255     


Leu His Leu Glu Pro Gln Asn Glu Leu Asp Pro Val Asp Leu Leu Cys 
            260                 265                 270         


Tyr Glu Gln Leu 
        275     


<210>  35
<211>  933
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide for antigen E7 of HPV16, HPV18 and HPV45 full


<220>
<221>  CDS
<222>  (1)..(933)

<400>  35
gaa gac gaa atc gac ggc cct gcg ggc cag gct gaa cca gat cgt gct         48
Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala           
1               5                   10                  15                

cac tac aac atc gta act ttt tgc tgt aag tgc gat agc act ctg cgt         96
His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg           
            20                  25                  30                    

ctg tgc gta cag tct act cac gtt gat atc cgc act ctg gaa gat ctg        144
Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu           
        35                  40                  45                        

ctg atg ggt acc ctg ggt atc gtc tgc cca atc tgc tct caa aag cct        192
Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro           
    50                  55                  60                            

gct tct ggt gtt aac cat cag cac ctg ccg gct cgt cgc gct gaa cca        240
Ala Ser Gly Val Asn His Gln His Leu Pro Ala Arg Arg Ala Glu Pro           
65                  70                  75                  80            

cag cgt cat acc atg ctg tgc atg tgt tgc aaa tgc gag gct cgc atc        288
Gln Arg His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile           
                85                  90                  95                

gaa ctg gtt gtt gaa tcc agc gct gac gac ctg cgt gcg ttt cag caa        336
Glu Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln           
            100                 105                 110                   

ctg ttc ctg aac acg ctg tct ttt gtt tgt ccg tgg tgt gcc tcc cag        384
Leu Phe Leu Asn Thr Leu Ser Phe Val Cys Pro Trp Cys Ala Ser Gln           
        115                 120                 125                       

cag gag aac gat gaa gcg gat ggc gtg tcc cac gcg cag ctg ccg gca        432
Gln Glu Asn Asp Glu Ala Asp Gly Val Ser His Ala Gln Leu Pro Ala           
    130                 135                 140                           

cgt cgt gca gaa ccg cag cgc cac aag att ctg tgc gtt tgc tgt aaa        480
Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys Val Cys Cys Lys           
145                 150                 155                 160           

tgt gat ggc cgt atc gaa ctg act gtg gaa tcc tcc gcg gaa gat ctg        528
Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser Ala Glu Asp Leu           
                165                 170                 175               

cgt acg ctg cag cag ctg ttc ctg tct acc ctg tct ttc gtg tgc ccg        576
Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe Val Cys Pro           
            180                 185                 190                   

tgg tgc gcc acc aat caa atg cac ggc gac acc ccg acc ctg cac gaa        624
Trp Cys Ala Thr Asn Gln Met His Gly Asp Thr Pro Thr Leu His Glu           
        195                 200                 205                       

tac atg ctg gac ctg cag ccg gaa acc acg gat ctg tat tgt tat gaa        672
Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu           
    210                 215                 220                           

cag ctg aac gat agc agc gag gaa atg cac ggt ccg aaa gca act ctg        720
Gln Leu Asn Asp Ser Ser Glu Glu Met His Gly Pro Lys Ala Thr Leu           
225                 230                 235                 240           

cag gac att gtg ctg cat ctg gag cca cag aac gaa atc ccg gtt gat        768
Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu Ile Pro Val Asp           
                245                 250                 255               

ctg ctg tgc cac gag caa ctg agc gat tcc gaa gag gaa aac gac gaa        816
Leu Leu Cys His Glu Gln Leu Ser Asp Ser Glu Glu Glu Asn Asp Glu           
            260                 265                 270                   

att gat atg cat ggt ccg cgc gag acc ctg caa gaa atc gtc ctg cac        864
Ile Asp Met His Gly Pro Arg Glu Thr Leu Gln Glu Ile Val Leu His           
        275                 280                 285                       

ctg gaa ccg caa aac gaa ctg gac cct gta gac ctg ctg tgc tac gaa        912
Leu Glu Pro Gln Asn Glu Leu Asp Pro Val Asp Leu Leu Cys Tyr Glu           
    290                 295                 300                           

cag ctg tcc gaa tct gaa gaa                                            933
Gln Leu Ser Glu Ser Glu Glu                                               
305                 310                                                   


<210>  36
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36

Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala 
1               5                   10                  15      


His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg 
            20                  25                  30          


Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu 
        35                  40                  45              


Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro 
    50                  55                  60                  


Ala Ser Gly Val Asn His Gln His Leu Pro Ala Arg Arg Ala Glu Pro 
65                  70                  75                  80  


Gln Arg His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile 
                85                  90                  95      


Glu Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln 
            100                 105                 110         


Leu Phe Leu Asn Thr Leu Ser Phe Val Cys Pro Trp Cys Ala Ser Gln 
        115                 120                 125             


Gln Glu Asn Asp Glu Ala Asp Gly Val Ser His Ala Gln Leu Pro Ala 
    130                 135                 140                 


Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys Val Cys Cys Lys 
145                 150                 155                 160 


Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser Ala Glu Asp Leu 
                165                 170                 175     


Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe Val Cys Pro 
            180                 185                 190         


Trp Cys Ala Thr Asn Gln Met His Gly Asp Thr Pro Thr Leu His Glu 
        195                 200                 205             


Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu 
    210                 215                 220                 


Gln Leu Asn Asp Ser Ser Glu Glu Met His Gly Pro Lys Ala Thr Leu 
225                 230                 235                 240 


Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu Ile Pro Val Asp 
                245                 250                 255     


Leu Leu Cys His Glu Gln Leu Ser Asp Ser Glu Glu Glu Asn Asp Glu 
            260                 265                 270         


Ile Asp Met His Gly Pro Arg Glu Thr Leu Gln Glu Ile Val Leu His 
        275                 280                 285             


Leu Glu Pro Gln Asn Glu Leu Asp Pro Val Asp Leu Leu Cys Tyr Glu 
    290                 295                 300                 


Gln Leu Ser Glu Ser Glu Glu 
305                 310     


<210>  37
<211>  1011
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide for antigen E7 of HPV31, 33, 52 and 58 
       acidic-deleted


<220>
<221>  CDS
<222>  (1)..(1011)

<400>  37
gcg ggt caa gcg aag ccg gat acg agc aac tat aac att gtc acg ttc         48
Ala Gly Gln Ala Lys Pro Asp Thr Ser Asn Tyr Asn Ile Val Thr Phe           
1               5                   10                  15                

tgc tgc cag tgt gaa agc acc ttg cgt ctg tgt gtc cag agc acc caa         96
Cys Cys Gln Cys Glu Ser Thr Leu Arg Leu Cys Val Gln Ser Thr Gln           
            20                  25                  30                    

gtt gac atc cgt att ctg cag gag ttg ctg atg ggc agc ttt ggc atc        144
Val Asp Ile Arg Ile Leu Gln Glu Leu Leu Met Gly Ser Phe Gly Ile           
        35                  40                  45                        

gtg tgc ccg aat tgc agc act cgc ctg ggt cag gca cag ccg gcc acc        192
Val Cys Pro Asn Cys Ser Thr Arg Leu Gly Gln Ala Gln Pro Ala Thr           
    50                  55                  60                            

gct gac tac tac att gtt act tgt tgc cat acc tgc aat acc acg gtc        240
Ala Asp Tyr Tyr Ile Val Thr Cys Cys His Thr Cys Asn Thr Thr Val           
65                  70                  75                  80            

cgc ctg tgc gtc aat tcc acc gct tcc gac ttg cgt acc att cag caa        288
Arg Leu Cys Val Asn Ser Thr Ala Ser Asp Leu Arg Thr Ile Gln Gln           
                85                  90                  95                

ctg ctg atg ggc acg gtt aac atc gtt tgc ccg tct tgt gcg cag ctg        336
Leu Leu Met Gly Thr Val Asn Ile Val Cys Pro Ser Cys Ala Gln Leu           
            100                 105                 110                   

ggc caa gcg gaa cag gcg acg agc aat tac tac atc gtg act tac tgt        384
Gly Gln Ala Glu Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr Cys           
        115                 120                 125                       

cac tcg tgt gac agc acg ctg cgt ttg tgc att cac agc acc gcg acc        432
His Ser Cys Asp Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala Thr           
    130                 135                 140                           

gat ctg cgt acg ctg caa caa ttg ctg atg ggt acc ctg cag gtg gtg        480
Asp Leu Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Leu Gln Val Val           
145                 150                 155                 160           

tgc cct ggt tgc gca cgt ctg ggt caa gct caa ccg gca acc gcg aac        528
Cys Pro Gly Cys Ala Arg Leu Gly Gln Ala Gln Pro Ala Thr Ala Asn           
                165                 170                 175               

tac tat atc gtt acg tgt tgt tat acg tgt gat acc acc gtt cgt ctg        576
Tyr Tyr Ile Val Thr Cys Cys Tyr Thr Cys Asp Thr Thr Val Arg Leu           
            180                 185                 190                   

tgc atc aac agc acc acc acc gat gtc cgc acg ctg caa caa ctg ctg        624
Cys Ile Asn Ser Thr Thr Thr Asp Val Arg Thr Leu Gln Gln Leu Leu           
        195                 200                 205                       

atg ggt acg tgt acg att gtt tgc ccg agc tgt gcc cag caa atg cgt        672
Met Gly Thr Cys Thr Ile Val Cys Pro Ser Cys Ala Gln Gln Met Arg           
    210                 215                 220                           

ggt gaa acc cca acg ctg cag gac tac gtg ctg gat ttg cag ccg gaa        720
Gly Glu Thr Pro Thr Leu Gln Asp Tyr Val Leu Asp Leu Gln Pro Glu           
225                 230                 235                 240           

gca acc gac ctg tac tgc tac gag cag ctg atg cgt ggt cac aag ccg        768
Ala Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Met Arg Gly His Lys Pro           
                245                 250                 255               

acg ctg aaa gag tat atc ttg gac ctg tat ccg gag cct acc gat ctg        816
Thr Leu Lys Glu Tyr Ile Leu Asp Leu Tyr Pro Glu Pro Thr Asp Leu           
            260                 265                 270                   

tat tgc tat gaa cag ctg agc atg cgt ggc gat aag gcg acc atc aaa        864
Tyr Cys Tyr Glu Gln Leu Ser Met Arg Gly Asp Lys Ala Thr Ile Lys           
        275                 280                 285                       

gac tac att ctg gac ttg cag ccg gaa acc acg gat ctg cat tgc tac        912
Asp Tyr Ile Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu His Cys Tyr           
    290                 295                 300                           

gaa caa ctg ggc atg cgc ggt aac aat ccg acc ctg cgc gag tat atc        960
Glu Gln Leu Gly Met Arg Gly Asn Asn Pro Thr Leu Arg Glu Tyr Ile           
305                 310                 315                 320           

ctg gat ctg cac cca gag ccg act gac ctg ttc tgc tat gag cag ttg       1008
Leu Asp Leu His Pro Glu Pro Thr Asp Leu Phe Cys Tyr Glu Gln Leu           
                325                 330                 335               

tgc                                                                   1011
Cys                                                                       
                                                                          


<210>  38
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38

Ala Gly Gln Ala Lys Pro Asp Thr Ser Asn Tyr Asn Ile Val Thr Phe 
1               5                   10                  15      


Cys Cys Gln Cys Glu Ser Thr Leu Arg Leu Cys Val Gln Ser Thr Gln 
            20                  25                  30          


Val Asp Ile Arg Ile Leu Gln Glu Leu Leu Met Gly Ser Phe Gly Ile 
        35                  40                  45              


Val Cys Pro Asn Cys Ser Thr Arg Leu Gly Gln Ala Gln Pro Ala Thr 
    50                  55                  60                  


Ala Asp Tyr Tyr Ile Val Thr Cys Cys His Thr Cys Asn Thr Thr Val 
65                  70                  75                  80  


Arg Leu Cys Val Asn Ser Thr Ala Ser Asp Leu Arg Thr Ile Gln Gln 
                85                  90                  95      


Leu Leu Met Gly Thr Val Asn Ile Val Cys Pro Ser Cys Ala Gln Leu 
            100                 105                 110         


Gly Gln Ala Glu Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr Cys 
        115                 120                 125             


His Ser Cys Asp Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala Thr 
    130                 135                 140                 


Asp Leu Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Leu Gln Val Val 
145                 150                 155                 160 


Cys Pro Gly Cys Ala Arg Leu Gly Gln Ala Gln Pro Ala Thr Ala Asn 
                165                 170                 175     


Tyr Tyr Ile Val Thr Cys Cys Tyr Thr Cys Asp Thr Thr Val Arg Leu 
            180                 185                 190         


Cys Ile Asn Ser Thr Thr Thr Asp Val Arg Thr Leu Gln Gln Leu Leu 
        195                 200                 205             


Met Gly Thr Cys Thr Ile Val Cys Pro Ser Cys Ala Gln Gln Met Arg 
    210                 215                 220                 


Gly Glu Thr Pro Thr Leu Gln Asp Tyr Val Leu Asp Leu Gln Pro Glu 
225                 230                 235                 240 


Ala Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Met Arg Gly His Lys Pro 
                245                 250                 255     


Thr Leu Lys Glu Tyr Ile Leu Asp Leu Tyr Pro Glu Pro Thr Asp Leu 
            260                 265                 270         


Tyr Cys Tyr Glu Gln Leu Ser Met Arg Gly Asp Lys Ala Thr Ile Lys 
        275                 280                 285             


Asp Tyr Ile Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu His Cys Tyr 
    290                 295                 300                 


Glu Gln Leu Gly Met Arg Gly Asn Asn Pro Thr Leu Arg Glu Tyr Ile 
305                 310                 315                 320 


Leu Asp Leu His Pro Glu Pro Thr Asp Leu Phe Cys Tyr Glu Gln Leu 
                325                 330                 335     


Cys 
    


<210>  39
<211>  1176
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide for antigen E7 of HPV31, 33, 52 and 58 full


<220>
<221>  CDS
<222>  (1)..(1176)

<400>  39
gat gaa gag gat gtc atc gat tcc cca gca ggc caa gca aag ccg gac         48
Asp Glu Glu Asp Val Ile Asp Ser Pro Ala Gly Gln Ala Lys Pro Asp           
1               5                   10                  15                

acc agc aat tac aat atc gtg acc ttc tgc tgc caa tgt gag tcc act         96
Thr Ser Asn Tyr Asn Ile Val Thr Phe Cys Cys Gln Cys Glu Ser Thr           
            20                  25                  30                    

ctg cgt ctg tgc gtt cag agc acc cag gtt gac att cgt att ctg caa        144
Leu Arg Leu Cys Val Gln Ser Thr Gln Val Asp Ile Arg Ile Leu Gln           
        35                  40                  45                        

gaa ttg ttg atg ggt agc ttt ggc att gtg tgt ccg aac tgc agc acc        192
Glu Leu Leu Met Gly Ser Phe Gly Ile Val Cys Pro Asn Cys Ser Thr           
    50                  55                  60                            

cgt ctg tcg gat gaa gat gaa ggt ctg gat cgt ccg gat ggt caa gcg        240
Arg Leu Ser Asp Glu Asp Glu Gly Leu Asp Arg Pro Asp Gly Gln Ala           
65                  70                  75                  80            

cag ccg gcg act gca gat tac tat atc gtc act tgt tgc cac acc tgc        288
Gln Pro Ala Thr Ala Asp Tyr Tyr Ile Val Thr Cys Cys His Thr Cys           
                85                  90                  95                

aat acc acc gtg cgt ctg tgt gtg aac agc acg gcg agc gac ctg cgc        336
Asn Thr Thr Val Arg Leu Cys Val Asn Ser Thr Ala Ser Asp Leu Arg           
            100                 105                 110                   

acg atc caa cag ttg ttg atg ggc acc gtg aat atc gtc tgc cca agc        384
Thr Ile Gln Gln Leu Leu Met Gly Thr Val Asn Ile Val Cys Pro Ser           
        115                 120                 125                       

tgt gct cag ttg agc gat gaa gag gac acc gac ggt gtc gac cgt ccg        432
Cys Ala Gln Leu Ser Asp Glu Glu Asp Thr Asp Gly Val Asp Arg Pro           
    130                 135                 140                           

gac ggc caa gct gag cag gcg acc agc aac tac tat atc gtt acg tac        480
Asp Gly Gln Ala Glu Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr           
145                 150                 155                 160           

tgt cac agc tgc gat agc act ctg cgc ctg tgt att cat agc acg gcc        528
Cys His Ser Cys Asp Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala           
                165                 170                 175               

acc gat ctg cgt acc ctg caa caa ctg ctg atg ggt act ctg cag gtt        576
Thr Asp Leu Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Leu Gln Val           
            180                 185                 190                   

gtg tgc cca ggt tgt gct cgt ctg tcc gac gag gac gaa atc ggc ctg        624
Val Cys Pro Gly Cys Ala Arg Leu Ser Asp Glu Asp Glu Ile Gly Leu           
        195                 200                 205                       

gac cgt cct gat ggc cag gcc cag ccg gca acg gcg aac tat tac att        672
Asp Arg Pro Asp Gly Gln Ala Gln Pro Ala Thr Ala Asn Tyr Tyr Ile           
    210                 215                 220                           

gtg acc tgc tgc tat acg tgc gat acc acg gtc cgt ctg tgc att aac        720
Val Thr Cys Cys Tyr Thr Cys Asp Thr Thr Val Arg Leu Cys Ile Asn           
225                 230                 235                 240           

tct acc acc acg gat gtt cgc acg ctg cag caa ctg ctg atg ggt acc        768
Ser Thr Thr Thr Asp Val Arg Thr Leu Gln Gln Leu Leu Met Gly Thr           
                245                 250                 255               

tgt acc att gtt tgc ccg tct tgt gcc cag cag atg cgc ggt gaa acg        816
Cys Thr Ile Val Cys Pro Ser Cys Ala Gln Gln Met Arg Gly Glu Thr           
            260                 265                 270                   

ccg acc ctg cag gat tat gtt ctg gac ctg caa ccg gag gcg acc gat        864
Pro Thr Leu Gln Asp Tyr Val Leu Asp Leu Gln Pro Glu Ala Thr Asp           
        275                 280                 285                       

ctg tat tgc tac gag caa ctg ccg gac agc tcg atg cgt ggt cac aaa        912
Leu Tyr Cys Tyr Glu Gln Leu Pro Asp Ser Ser Met Arg Gly His Lys           
    290                 295                 300                           

ccg acg ctg aaa gag tac atc ctg gac ctg tac ccg gaa cct acg gat        960
Pro Thr Leu Lys Glu Tyr Ile Leu Asp Leu Tyr Pro Glu Pro Thr Asp           
305                 310                 315                 320           

ctg tac tgt tat gaa caa ctg agc gat agc atg cgt ggt gac aag gcg       1008
Leu Tyr Cys Tyr Glu Gln Leu Ser Asp Ser Met Arg Gly Asp Lys Ala           
                325                 330                 335               

acg att aag gac tac atc ttg gat ctg cag ccg gaa acc acc gac ctg       1056
Thr Ile Lys Asp Tyr Ile Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu           
            340                 345                 350                   

cac tgc tat gag cag ctg ggt gat tct atg cgc ggt aac aat ccg acc       1104
His Cys Tyr Glu Gln Leu Gly Asp Ser Met Arg Gly Asn Asn Pro Thr           
        355                 360                 365                       

ctg cgc gag tac att ctg gac ttg cat ccg gaa ccg acg gac ctg ttc       1152
Leu Arg Glu Tyr Ile Leu Asp Leu His Pro Glu Pro Thr Asp Leu Phe           
    370                 375                 380                           

tgt tac gag cag ctg tgt gac agc                                       1176
Cys Tyr Glu Gln Leu Cys Asp Ser                                           
385                 390                                                   


<210>  40
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40

Asp Glu Glu Asp Val Ile Asp Ser Pro Ala Gly Gln Ala Lys Pro Asp 
1               5                   10                  15      


Thr Ser Asn Tyr Asn Ile Val Thr Phe Cys Cys Gln Cys Glu Ser Thr 
            20                  25                  30          


Leu Arg Leu Cys Val Gln Ser Thr Gln Val Asp Ile Arg Ile Leu Gln 
        35                  40                  45              


Glu Leu Leu Met Gly Ser Phe Gly Ile Val Cys Pro Asn Cys Ser Thr 
    50                  55                  60                  


Arg Leu Ser Asp Glu Asp Glu Gly Leu Asp Arg Pro Asp Gly Gln Ala 
65                  70                  75                  80  


Gln Pro Ala Thr Ala Asp Tyr Tyr Ile Val Thr Cys Cys His Thr Cys 
                85                  90                  95      


Asn Thr Thr Val Arg Leu Cys Val Asn Ser Thr Ala Ser Asp Leu Arg 
            100                 105                 110         


Thr Ile Gln Gln Leu Leu Met Gly Thr Val Asn Ile Val Cys Pro Ser 
        115                 120                 125             


Cys Ala Gln Leu Ser Asp Glu Glu Asp Thr Asp Gly Val Asp Arg Pro 
    130                 135                 140                 


Asp Gly Gln Ala Glu Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr 
145                 150                 155                 160 


Cys His Ser Cys Asp Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala 
                165                 170                 175     


Thr Asp Leu Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Leu Gln Val 
            180                 185                 190         


Val Cys Pro Gly Cys Ala Arg Leu Ser Asp Glu Asp Glu Ile Gly Leu 
        195                 200                 205             


Asp Arg Pro Asp Gly Gln Ala Gln Pro Ala Thr Ala Asn Tyr Tyr Ile 
    210                 215                 220                 


Val Thr Cys Cys Tyr Thr Cys Asp Thr Thr Val Arg Leu Cys Ile Asn 
225                 230                 235                 240 


Ser Thr Thr Thr Asp Val Arg Thr Leu Gln Gln Leu Leu Met Gly Thr 
                245                 250                 255     


Cys Thr Ile Val Cys Pro Ser Cys Ala Gln Gln Met Arg Gly Glu Thr 
            260                 265                 270         


Pro Thr Leu Gln Asp Tyr Val Leu Asp Leu Gln Pro Glu Ala Thr Asp 
        275                 280                 285             


Leu Tyr Cys Tyr Glu Gln Leu Pro Asp Ser Ser Met Arg Gly His Lys 
    290                 295                 300                 


Pro Thr Leu Lys Glu Tyr Ile Leu Asp Leu Tyr Pro Glu Pro Thr Asp 
305                 310                 315                 320 


Leu Tyr Cys Tyr Glu Gln Leu Ser Asp Ser Met Arg Gly Asp Lys Ala 
                325                 330                 335     


Thr Ile Lys Asp Tyr Ile Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu 
            340                 345                 350         


His Cys Tyr Glu Gln Leu Gly Asp Ser Met Arg Gly Asn Asn Pro Thr 
        355                 360                 365             


Leu Arg Glu Tyr Ile Leu Asp Leu His Pro Glu Pro Thr Asp Leu Phe 
    370                 375                 380                 


Cys Tyr Glu Gln Leu Cys Asp Ser 
385                 390         


<210>  41
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide for antigen E7 of HPV31, 52 and 58 acidic-deleted


<220>
<221>  CDS
<222>  (1)..(759)

<400>  41
gcg ggt caa gcc aaa ccg gat acc tcc aac tac aac att gtg acc ttc         48
Ala Gly Gln Ala Lys Pro Asp Thr Ser Asn Tyr Asn Ile Val Thr Phe           
1               5                   10                  15                

tgt tgt caa tgc gag agc acg ctg cgt ctg tgt gtt caa agc acc cag         96
Cys Cys Gln Cys Glu Ser Thr Leu Arg Leu Cys Val Gln Ser Thr Gln           
            20                  25                  30                    

gtt gac att cgt atc ctg caa gaa ctg ctg atg ggc tct ttt ggc atc        144
Val Asp Ile Arg Ile Leu Gln Glu Leu Leu Met Gly Ser Phe Gly Ile           
        35                  40                  45                        

gtc tgc cca aat tgc agc act cgc ctg ggc cag gcg gag cag gcg acg        192
Val Cys Pro Asn Cys Ser Thr Arg Leu Gly Gln Ala Glu Gln Ala Thr           
    50                  55                  60                            

agc aac tac tac att gtc acg tat tgc cat tcc tgt gat agc act ctg        240
Ser Asn Tyr Tyr Ile Val Thr Tyr Cys His Ser Cys Asp Ser Thr Leu           
65                  70                  75                  80            

cgt ctg tgt atc cac agc acg gca acc gat ctg cgt acc ttg caa caa        288
Arg Leu Cys Ile His Ser Thr Ala Thr Asp Leu Arg Thr Leu Gln Gln           
                85                  90                  95                

ctg ctg atg ggc acc ctg cag gtg gtt tgt ccg ggt tgc gct cgc ctg        336
Leu Leu Met Gly Thr Leu Gln Val Val Cys Pro Gly Cys Ala Arg Leu           
            100                 105                 110                   

ggc cag gcg cag cca gcg acg gcc aat tac tac atc gtt acc tgt tgc        384
Gly Gln Ala Gln Pro Ala Thr Ala Asn Tyr Tyr Ile Val Thr Cys Cys           
        115                 120                 125                       

tat acg tgc gat act acc gtc cgt ctg tgc att aac agc acc acc acg        432
Tyr Thr Cys Asp Thr Thr Val Arg Leu Cys Ile Asn Ser Thr Thr Thr           
    130                 135                 140                           

gac gtg cgt acc ctg caa cag ctg ctg atg ggt acc tgc acg att gtt        480
Asp Val Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Cys Thr Ile Val           
145                 150                 155                 160           

tgt ccg agc tgt gca caa caa atg cgt ggt gaa acg ccg acc ctg cag        528
Cys Pro Ser Cys Ala Gln Gln Met Arg Gly Glu Thr Pro Thr Leu Gln           
                165                 170                 175               

gat tat gtg ttg gac ttg cag ccg gag gca acg gac ctg tac tgc tat        576
Asp Tyr Val Leu Asp Leu Gln Pro Glu Ala Thr Asp Leu Tyr Cys Tyr           
            180                 185                 190                   

gag cag ctg atg cgt ggt gac aag gcc acc att aaa gat tac atc ctg        624
Glu Gln Leu Met Arg Gly Asp Lys Ala Thr Ile Lys Asp Tyr Ile Leu           
        195                 200                 205                       

gac ttg caa ccg gaa acc acc gac ctg cac tgc tat gag cag ctg ggt        672
Asp Leu Gln Pro Glu Thr Thr Asp Leu His Cys Tyr Glu Gln Leu Gly           
    210                 215                 220                           

atg cgc ggt aat aac ccg acc ttg cgt gag tat atc ttg gac ctg cac        720
Met Arg Gly Asn Asn Pro Thr Leu Arg Glu Tyr Ile Leu Asp Leu His           
225                 230                 235                 240           

ccg gag ccg acc gat ctg ttc tgt tac gaa cag ctg tgc                    759
Pro Glu Pro Thr Asp Leu Phe Cys Tyr Glu Gln Leu Cys                       
                245                 250                                   


<210>  42
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42

Ala Gly Gln Ala Lys Pro Asp Thr Ser Asn Tyr Asn Ile Val Thr Phe 
1               5                   10                  15      


Cys Cys Gln Cys Glu Ser Thr Leu Arg Leu Cys Val Gln Ser Thr Gln 
            20                  25                  30          


Val Asp Ile Arg Ile Leu Gln Glu Leu Leu Met Gly Ser Phe Gly Ile 
        35                  40                  45              


Val Cys Pro Asn Cys Ser Thr Arg Leu Gly Gln Ala Glu Gln Ala Thr 
    50                  55                  60                  


Ser Asn Tyr Tyr Ile Val Thr Tyr Cys His Ser Cys Asp Ser Thr Leu 
65                  70                  75                  80  


Arg Leu Cys Ile His Ser Thr Ala Thr Asp Leu Arg Thr Leu Gln Gln 
                85                  90                  95      


Leu Leu Met Gly Thr Leu Gln Val Val Cys Pro Gly Cys Ala Arg Leu 
            100                 105                 110         


Gly Gln Ala Gln Pro Ala Thr Ala Asn Tyr Tyr Ile Val Thr Cys Cys 
        115                 120                 125             


Tyr Thr Cys Asp Thr Thr Val Arg Leu Cys Ile Asn Ser Thr Thr Thr 
    130                 135                 140                 


Asp Val Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Cys Thr Ile Val 
145                 150                 155                 160 


Cys Pro Ser Cys Ala Gln Gln Met Arg Gly Glu Thr Pro Thr Leu Gln 
                165                 170                 175     


Asp Tyr Val Leu Asp Leu Gln Pro Glu Ala Thr Asp Leu Tyr Cys Tyr 
            180                 185                 190         


Glu Gln Leu Met Arg Gly Asp Lys Ala Thr Ile Lys Asp Tyr Ile Leu 
        195                 200                 205             


Asp Leu Gln Pro Glu Thr Thr Asp Leu His Cys Tyr Glu Gln Leu Gly 
    210                 215                 220                 


Met Arg Gly Asn Asn Pro Thr Leu Arg Glu Tyr Ile Leu Asp Leu His 
225                 230                 235                 240 


Pro Glu Pro Thr Asp Leu Phe Cys Tyr Glu Gln Leu Cys 
                245                 250             


<210>  43
<211>  885
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide for antigen E7 of HPV31, 52 and 58 full


<220>
<221>  CDS
<222>  (1)..(885)

<400>  43
gat gaa gag gat gtc atc gat tcc cca gca ggc caa gca aag ccg gac         48
Asp Glu Glu Asp Val Ile Asp Ser Pro Ala Gly Gln Ala Lys Pro Asp           
1               5                   10                  15                

acc agc aat tac aat atc gtg acc ttc tgc tgc caa tgt gag tcc act         96
Thr Ser Asn Tyr Asn Ile Val Thr Phe Cys Cys Gln Cys Glu Ser Thr           
            20                  25                  30                    

ctg cgt ctg tgc gtt cag agc acc cag gtt gac att cgt att ctg caa        144
Leu Arg Leu Cys Val Gln Ser Thr Gln Val Asp Ile Arg Ile Leu Gln           
        35                  40                  45                        

gaa ttg ttg atg ggt agc ttt ggc att gtg tgt ccg aac tgc agc acc        192
Glu Leu Leu Met Gly Ser Phe Gly Ile Val Cys Pro Asn Cys Ser Thr           
    50                  55                  60                            

cgt ctg agc gat gaa gag gac acc gac ggt gtc gac cgt ccg gac ggc        240
Arg Leu Ser Asp Glu Glu Asp Thr Asp Gly Val Asp Arg Pro Asp Gly           
65                  70                  75                  80            

caa gct gag cag gcg acc agc aac tac tat atc gtt acg tac tgt cac        288
Gln Ala Glu Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr Cys His           
                85                  90                  95                

agc tgc gat agc act ctg cgc ctg tgt att cat agc acg gcc acc gat        336
Ser Cys Asp Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala Thr Asp           
            100                 105                 110                   

ctg cgt acc ctg caa caa ctg ctg atg ggt act ctg cag gtt gtg tgc        384
Leu Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Leu Gln Val Val Cys           
        115                 120                 125                       

cca ggt tgt gct cgt ctg tcc gac gag gac gaa atc ggc ctg gac cgt        432
Pro Gly Cys Ala Arg Leu Ser Asp Glu Asp Glu Ile Gly Leu Asp Arg           
    130                 135                 140                           

cct gat ggc cag gcc cag ccg gca acg gcg aac tat tac att gtg acc        480
Pro Asp Gly Gln Ala Gln Pro Ala Thr Ala Asn Tyr Tyr Ile Val Thr           
145                 150                 155                 160           

tgc tgc tat acg tgc gat acc acg gtc cgt ctg tgc att aac tct acc        528
Cys Cys Tyr Thr Cys Asp Thr Thr Val Arg Leu Cys Ile Asn Ser Thr           
                165                 170                 175               

acc acg gat gtt cgc acg ctg cag caa ctg ctg atg ggt acc tgt acc        576
Thr Thr Asp Val Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Cys Thr           
            180                 185                 190                   

att gtt tgc ccg tct tgt gcc cag cag atg cgc ggt gaa acg ccg acc        624
Ile Val Cys Pro Ser Cys Ala Gln Gln Met Arg Gly Glu Thr Pro Thr           
        195                 200                 205                       

ctg cag gat tat gtt ctg gac ctg caa ccg gag gcg acc gat ctg tat        672
Leu Gln Asp Tyr Val Leu Asp Leu Gln Pro Glu Ala Thr Asp Leu Tyr           
    210                 215                 220                           

tgc tac gag caa ctg ccg gac agc tcg atg cgt ggt gac aag gcg acg        720
Cys Tyr Glu Gln Leu Pro Asp Ser Ser Met Arg Gly Asp Lys Ala Thr           
225                 230                 235                 240           

att aag gac tac atc ttg gat ctg cag ccg gaa acc acc gac ctg cac        768
Ile Lys Asp Tyr Ile Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu His           
                245                 250                 255               

tgc tat gag cag ctg ggt gat tct atg cgc ggt aac aat ccg acc ctg        816
Cys Tyr Glu Gln Leu Gly Asp Ser Met Arg Gly Asn Asn Pro Thr Leu           
            260                 265                 270                   

cgc gag tac att ctg gac ttg cat ccg gaa ccg acg gac ctg ttc tgt        864
Arg Glu Tyr Ile Leu Asp Leu His Pro Glu Pro Thr Asp Leu Phe Cys           
        275                 280                 285                       

tac gag cag ctg tgt gac agc                                            885
Tyr Glu Gln Leu Cys Asp Ser                                               
    290                 295                                               


<210>  44
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44

Asp Glu Glu Asp Val Ile Asp Ser Pro Ala Gly Gln Ala Lys Pro Asp 
1               5                   10                  15      


Thr Ser Asn Tyr Asn Ile Val Thr Phe Cys Cys Gln Cys Glu Ser Thr 
            20                  25                  30          


Leu Arg Leu Cys Val Gln Ser Thr Gln Val Asp Ile Arg Ile Leu Gln 
        35                  40                  45              


Glu Leu Leu Met Gly Ser Phe Gly Ile Val Cys Pro Asn Cys Ser Thr 
    50                  55                  60                  


Arg Leu Ser Asp Glu Glu Asp Thr Asp Gly Val Asp Arg Pro Asp Gly 
65                  70                  75                  80  


Gln Ala Glu Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr Cys His 
                85                  90                  95      


Ser Cys Asp Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala Thr Asp 
            100                 105                 110         


Leu Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Leu Gln Val Val Cys 
        115                 120                 125             


Pro Gly Cys Ala Arg Leu Ser Asp Glu Asp Glu Ile Gly Leu Asp Arg 
    130                 135                 140                 


Pro Asp Gly Gln Ala Gln Pro Ala Thr Ala Asn Tyr Tyr Ile Val Thr 
145                 150                 155                 160 


Cys Cys Tyr Thr Cys Asp Thr Thr Val Arg Leu Cys Ile Asn Ser Thr 
                165                 170                 175     


Thr Thr Asp Val Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Cys Thr 
            180                 185                 190         


Ile Val Cys Pro Ser Cys Ala Gln Gln Met Arg Gly Glu Thr Pro Thr 
        195                 200                 205             


Leu Gln Asp Tyr Val Leu Asp Leu Gln Pro Glu Ala Thr Asp Leu Tyr 
    210                 215                 220                 


Cys Tyr Glu Gln Leu Pro Asp Ser Ser Met Arg Gly Asp Lys Ala Thr 
225                 230                 235                 240 


Ile Lys Asp Tyr Ile Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu His 
                245                 250                 255     


Cys Tyr Glu Gln Leu Gly Asp Ser Met Arg Gly Asn Asn Pro Thr Leu 
            260                 265                 270         


Arg Glu Tyr Ile Leu Asp Leu His Pro Glu Pro Thr Asp Leu Phe Cys 
        275                 280                 285             


Tyr Glu Gln Leu Cys Asp Ser 
    290                 295 


<210>  45
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide for antigen E7 of HPV31, 33 and 52 acidic-deleted


<220>
<221>  CDS
<222>  (1)..(759)

<400>  45
gcg ggt caa gcc aaa ccg gat acc tcc aac tac aac att gtg acc ttc         48
Ala Gly Gln Ala Lys Pro Asp Thr Ser Asn Tyr Asn Ile Val Thr Phe           
1               5                   10                  15                

tgt tgt caa tgc gag agc acg ctg cgt ctg tgt gtt caa agc acc cag         96
Cys Cys Gln Cys Glu Ser Thr Leu Arg Leu Cys Val Gln Ser Thr Gln           
            20                  25                  30                    

gtt gac att cgt atc ctg caa gaa ctg ctg atg ggc tct ttt ggc atc        144
Val Asp Ile Arg Ile Leu Gln Glu Leu Leu Met Gly Ser Phe Gly Ile           
        35                  40                  45                        

gtc tgc cca aat tgc agc act cgc ctg ggt cag gcg caa ccg gcc acg        192
Val Cys Pro Asn Cys Ser Thr Arg Leu Gly Gln Ala Gln Pro Ala Thr           
    50                  55                  60                            

gcg gac tac tat atc gtg acc tgt tgc cac acc tgc aac act acc gtt        240
Ala Asp Tyr Tyr Ile Val Thr Cys Cys His Thr Cys Asn Thr Thr Val           
65                  70                  75                  80            

cgc ttg tgt gtc aat agc acc gct tcc gat ctg cgt acc att caa caa        288
Arg Leu Cys Val Asn Ser Thr Ala Ser Asp Leu Arg Thr Ile Gln Gln           
                85                  90                  95                

ctg ctg atg ggt acc gtt aac atc gtg tgc ccg agc tgc gca cag ctg        336
Leu Leu Met Gly Thr Val Asn Ile Val Cys Pro Ser Cys Ala Gln Leu           
            100                 105                 110                   

ggc cag gcg gag cag gcg acg agc aac tac tac att gtc acg tat tgc        384
Gly Gln Ala Glu Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr Cys           
        115                 120                 125                       

cat tcc tgt gat agc act ctg cgt ctg tgt atc cac agc acg gca acc        432
His Ser Cys Asp Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala Thr           
    130                 135                 140                           

gat ctg cgt acc ttg caa caa ctg ctg atg ggc acc ctg cag gtg gtt        480
Asp Leu Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Leu Gln Val Val           
145                 150                 155                 160           

tgt ccg ggt tgc gct cgc ctg atg cgt ggt gaa acg ccg acc ctg cag        528
Cys Pro Gly Cys Ala Arg Leu Met Arg Gly Glu Thr Pro Thr Leu Gln           
                165                 170                 175               

gat tat gtg ttg gac ttg cag ccg gag gca acg gac ctg tac tgc tat        576
Asp Tyr Val Leu Asp Leu Gln Pro Glu Ala Thr Asp Leu Tyr Cys Tyr           
            180                 185                 190                   

gag cag ctg atg cgt ggc cat aag ccg acg ctg aaa gag tat att ctg        624
Glu Gln Leu Met Arg Gly His Lys Pro Thr Leu Lys Glu Tyr Ile Leu           
        195                 200                 205                       

gac ctg tac cca gag ccg acg gat ttg tac tgt tat gaa cag ctg agc        672
Asp Leu Tyr Pro Glu Pro Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Ser           
    210                 215                 220                           

atg cgt ggt gac aag gcc acc att aaa gat tac atc ctg gac ttg caa        720
Met Arg Gly Asp Lys Ala Thr Ile Lys Asp Tyr Ile Leu Asp Leu Gln           
225                 230                 235                 240           

ccg gaa acc acc gac ctg cac tgc tat gag cag ctg ggt                    759
Pro Glu Thr Thr Asp Leu His Cys Tyr Glu Gln Leu Gly                       
                245                 250                                   


<210>  46
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46

Ala Gly Gln Ala Lys Pro Asp Thr Ser Asn Tyr Asn Ile Val Thr Phe 
1               5                   10                  15      


Cys Cys Gln Cys Glu Ser Thr Leu Arg Leu Cys Val Gln Ser Thr Gln 
            20                  25                  30          


Val Asp Ile Arg Ile Leu Gln Glu Leu Leu Met Gly Ser Phe Gly Ile 
        35                  40                  45              


Val Cys Pro Asn Cys Ser Thr Arg Leu Gly Gln Ala Gln Pro Ala Thr 
    50                  55                  60                  


Ala Asp Tyr Tyr Ile Val Thr Cys Cys His Thr Cys Asn Thr Thr Val 
65                  70                  75                  80  


Arg Leu Cys Val Asn Ser Thr Ala Ser Asp Leu Arg Thr Ile Gln Gln 
                85                  90                  95      


Leu Leu Met Gly Thr Val Asn Ile Val Cys Pro Ser Cys Ala Gln Leu 
            100                 105                 110         


Gly Gln Ala Glu Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr Cys 
        115                 120                 125             


His Ser Cys Asp Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala Thr 
    130                 135                 140                 


Asp Leu Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Leu Gln Val Val 
145                 150                 155                 160 


Cys Pro Gly Cys Ala Arg Leu Met Arg Gly Glu Thr Pro Thr Leu Gln 
                165                 170                 175     


Asp Tyr Val Leu Asp Leu Gln Pro Glu Ala Thr Asp Leu Tyr Cys Tyr 
            180                 185                 190         


Glu Gln Leu Met Arg Gly His Lys Pro Thr Leu Lys Glu Tyr Ile Leu 
        195                 200                 205             


Asp Leu Tyr Pro Glu Pro Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Ser 
    210                 215                 220                 


Met Arg Gly Asp Lys Ala Thr Ile Lys Asp Tyr Ile Leu Asp Leu Gln 
225                 230                 235                 240 


Pro Glu Thr Thr Asp Leu His Cys Tyr Glu Gln Leu Gly 
                245                 250             


<210>  47
<211>  882
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide for antigen E7 of HPV31, 33 and 52 full


<220>
<221>  CDS
<222>  (1)..(882)

<400>  47
gat gaa gag gat gtc atc gat tcc cca gca ggc caa gca aag ccg gac         48
Asp Glu Glu Asp Val Ile Asp Ser Pro Ala Gly Gln Ala Lys Pro Asp           
1               5                   10                  15                

acc agc aat tac aat atc gtg acc ttc tgc tgc caa tgt gag tcc act         96
Thr Ser Asn Tyr Asn Ile Val Thr Phe Cys Cys Gln Cys Glu Ser Thr           
            20                  25                  30                    

ctg cgt ctg tgc gtt cag agc acc cag gtt gac att cgt att ctg caa        144
Leu Arg Leu Cys Val Gln Ser Thr Gln Val Asp Ile Arg Ile Leu Gln           
        35                  40                  45                        

gaa ttg ttg atg ggt agc ttt ggc att gtg tgt ccg aac tgc agc acc        192
Glu Leu Leu Met Gly Ser Phe Gly Ile Val Cys Pro Asn Cys Ser Thr           
    50                  55                  60                            

cgt ctg tcg gat gaa gat gaa ggt ctg gat cgt ccg gat ggt caa gcg        240
Arg Leu Ser Asp Glu Asp Glu Gly Leu Asp Arg Pro Asp Gly Gln Ala           
65                  70                  75                  80            

cag ccg gcg act gca gat tac tat atc gtc act tgt tgc cac acc tgc        288
Gln Pro Ala Thr Ala Asp Tyr Tyr Ile Val Thr Cys Cys His Thr Cys           
                85                  90                  95                

aat acc acc gtg cgt ctg tgt gtg aac agc acg gcg agc gac ctg cgc        336
Asn Thr Thr Val Arg Leu Cys Val Asn Ser Thr Ala Ser Asp Leu Arg           
            100                 105                 110                   

acg atc caa cag ttg ttg atg ggc acc gtg aat atc gtc tgc cca agc        384
Thr Ile Gln Gln Leu Leu Met Gly Thr Val Asn Ile Val Cys Pro Ser           
        115                 120                 125                       

tgt gct cag ttg agc gat gaa gag gac acc gac ggt gtc gac cgt ccg        432
Cys Ala Gln Leu Ser Asp Glu Glu Asp Thr Asp Gly Val Asp Arg Pro           
    130                 135                 140                           

gac ggc caa gct gag cag gcg acc agc aac tac tat atc gtt acg tac        480
Asp Gly Gln Ala Glu Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr           
145                 150                 155                 160           

tgt cac agc tgc gat agc act ctg cgc ctg tgt att cat agc acg gcc        528
Cys His Ser Cys Asp Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala           
                165                 170                 175               

acc gat ctg cgt acc ctg caa caa ctg ctg atg ggt act ctg cag gtt        576
Thr Asp Leu Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Leu Gln Val           
            180                 185                 190                   

gtg tgc cca ggt tgt gct cgt ctg atg cgc ggt gaa acg ccg acc ctg        624
Val Cys Pro Gly Cys Ala Arg Leu Met Arg Gly Glu Thr Pro Thr Leu           
        195                 200                 205                       

cag gat tat gtt ctg gac ctg caa ccg gag gcg acc gat ctg tat tgc        672
Gln Asp Tyr Val Leu Asp Leu Gln Pro Glu Ala Thr Asp Leu Tyr Cys           
    210                 215                 220                           

tac gag caa ctg ccg gac agc tcg atg cgt ggt cac aaa ccg acg ctg        720
Tyr Glu Gln Leu Pro Asp Ser Ser Met Arg Gly His Lys Pro Thr Leu           
225                 230                 235                 240           

aaa gag tac atc ctg gac ctg tac ccg gaa cct acg gat ctg tac tgt        768
Lys Glu Tyr Ile Leu Asp Leu Tyr Pro Glu Pro Thr Asp Leu Tyr Cys           
                245                 250                 255               

tat gaa caa ctg agc gat agc atg cgt ggt gac aag gcg acg att aag        816
Tyr Glu Gln Leu Ser Asp Ser Met Arg Gly Asp Lys Ala Thr Ile Lys           
            260                 265                 270                   

gac tac atc ttg gat ctg cag ccg gaa acc acc gac ctg cac tgc tat        864
Asp Tyr Ile Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu His Cys Tyr           
        275                 280                 285                       

gag cag ctg ggt gat tct                                                882
Glu Gln Leu Gly Asp Ser                                                   
    290                                                                   


<210>  48
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48

Asp Glu Glu Asp Val Ile Asp Ser Pro Ala Gly Gln Ala Lys Pro Asp 
1               5                   10                  15      


Thr Ser Asn Tyr Asn Ile Val Thr Phe Cys Cys Gln Cys Glu Ser Thr 
            20                  25                  30          


Leu Arg Leu Cys Val Gln Ser Thr Gln Val Asp Ile Arg Ile Leu Gln 
        35                  40                  45              


Glu Leu Leu Met Gly Ser Phe Gly Ile Val Cys Pro Asn Cys Ser Thr 
    50                  55                  60                  


Arg Leu Ser Asp Glu Asp Glu Gly Leu Asp Arg Pro Asp Gly Gln Ala 
65                  70                  75                  80  


Gln Pro Ala Thr Ala Asp Tyr Tyr Ile Val Thr Cys Cys His Thr Cys 
                85                  90                  95      


Asn Thr Thr Val Arg Leu Cys Val Asn Ser Thr Ala Ser Asp Leu Arg 
            100                 105                 110         


Thr Ile Gln Gln Leu Leu Met Gly Thr Val Asn Ile Val Cys Pro Ser 
        115                 120                 125             


Cys Ala Gln Leu Ser Asp Glu Glu Asp Thr Asp Gly Val Asp Arg Pro 
    130                 135                 140                 


Asp Gly Gln Ala Glu Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr 
145                 150                 155                 160 


Cys His Ser Cys Asp Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala 
                165                 170                 175     


Thr Asp Leu Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Leu Gln Val 
            180                 185                 190         


Val Cys Pro Gly Cys Ala Arg Leu Met Arg Gly Glu Thr Pro Thr Leu 
        195                 200                 205             


Gln Asp Tyr Val Leu Asp Leu Gln Pro Glu Ala Thr Asp Leu Tyr Cys 
    210                 215                 220                 


Tyr Glu Gln Leu Pro Asp Ser Ser Met Arg Gly His Lys Pro Thr Leu 
225                 230                 235                 240 


Lys Glu Tyr Ile Leu Asp Leu Tyr Pro Glu Pro Thr Asp Leu Tyr Cys 
                245                 250                 255     


Tyr Glu Gln Leu Ser Asp Ser Met Arg Gly Asp Lys Ala Thr Ile Lys 
            260                 265                 270         


Asp Tyr Ile Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu His Cys Tyr 
        275                 280                 285             


Glu Gln Leu Gly Asp Ser 
    290                 


<210>  49
<211>  1080
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide for antigen E7 of HPV16, 18, 33 and 45 
       acidic-deleted


<220>
<221>  CDS
<222>  (1)..(1080)

<400>  49
ggt cag gcg gaa ccg gat cgc gcg cac tac aac atc gtt act ttt tgt         48
Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys           
1               5                   10                  15                

tgc aaa tgt gat tcc act ctg cgc ctg tgt gtg caa tcc acc cac gta         96
Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val           
            20                  25                  30                    

gac atc cgc act ctg gaa gac ctg ctg atg ggt acc ctg ggt att gtt        144
Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val           
        35                  40                  45                        

tgt ccg att tgc tcc cag aag ccg gcg tct ggc gtt aac cac caa cac        192
Cys Pro Ile Cys Ser Gln Lys Pro Ala Ser Gly Val Asn His Gln His           
    50                  55                  60                            

ctg ccg gcg cgt cgc gca gag ccg cag cgt cac acc atg ctg tgc atg        240
Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met           
65                  70                  75                  80            

tgc tgt aaa tgt gag gcc cgt att gaa ctg gtc gtt gag tct agc gcc        288
Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala           
                85                  90                  95                

gac gat ctg cgt gcg ttt cag cag ctg ttc ctg aac acg ctg agc ttc        336
Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe           
            100                 105                 110                   

gtt tgc ccg tgg tgt gct agc cag cag ggc gtg tct cac gct cag ctg        384
Val Cys Pro Trp Cys Ala Ser Gln Gln Gly Val Ser His Ala Gln Leu           
        115                 120                 125                       

ccg gca cgt cgt gct gag cct cag cgt cac aaa atc ctg tgc gtg tgc        432
Pro Ala Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys Val Cys           
    130                 135                 140                           

tgc aaa tgc gat ggc cgc atc gaa ctg acc gtg gaa tct agc gca gaa        480
Cys Lys Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser Ala Glu           
145                 150                 155                 160           

gac ctg cgt acg ctg cag caa ctg ttc ctg agc acg ctg tcc ttc gta        528
Asp Leu Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe Val           
                165                 170                 175               

tgc cct tgg tgc gca act aat cag ggt cag gcg caa ccg gcc acg gcg        576
Cys Pro Trp Cys Ala Thr Asn Gln Gly Gln Ala Gln Pro Ala Thr Ala           
            180                 185                 190                   

gac tac tat atc gtg acc tgt tgc cac acc tgc aac act acc gtt cgc        624
Asp Tyr Tyr Ile Val Thr Cys Cys His Thr Cys Asn Thr Thr Val Arg           
        195                 200                 205                       

ttg tgt gtc aat agc acc gct tcc gat ctg cgt acc att caa caa ctg        672
Leu Cys Val Asn Ser Thr Ala Ser Asp Leu Arg Thr Ile Gln Gln Leu           
    210                 215                 220                           

ctg atg ggt acc gtt aac atc gtg tgc ccg agc tgc gca cag ctg atg        720
Leu Met Gly Thr Val Asn Ile Val Cys Pro Ser Cys Ala Gln Leu Met           
225                 230                 235                 240           

cac ggt gac acc ccg acc ctg cac gaa tac atg ctg gac ctg cag cca        768
His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro           
                245                 250                 255               

gaa acc acc gat ctg tac tgt tac gaa cag ctg aac atg cat ggc cca        816
Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Met His Gly Pro           
            260                 265                 270                   

aaa gct act ctg cag gat atc gtc ctg cat ctg gaa cca cag aac gaa        864
Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu           
        275                 280                 285                       

atc ccg gta gat ctg ctg tgc cat gag cag ctg atg cat ggt ccg cgt        912
Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Met His Gly Pro Arg           
    290                 295                 300                           

gaa acc ctg cag gaa atc gtt ctg cac ctg gaa ccg caa aac gaa ctg        960
Glu Thr Leu Gln Glu Ile Val Leu His Leu Glu Pro Gln Asn Glu Leu           
305                 310                 315                 320           

gac ccg gtt gac ctg ctg tgc tat gaa cag ctg atg cgt ggc cat aag       1008
Asp Pro Val Asp Leu Leu Cys Tyr Glu Gln Leu Met Arg Gly His Lys           
                325                 330                 335               

ccg acg ctg aaa gag tat att ctg gac ctg tac cca gag ccg acg gat       1056
Pro Thr Leu Lys Glu Tyr Ile Leu Asp Leu Tyr Pro Glu Pro Thr Asp           
            340                 345                 350                   

ttg tac tgt tat gaa cag ctg agc                                       1080
Leu Tyr Cys Tyr Glu Gln Leu Ser                                           
        355                 360                                           


<210>  50
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50

Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys 
1               5                   10                  15      


Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val 
            20                  25                  30          


Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val 
        35                  40                  45              


Cys Pro Ile Cys Ser Gln Lys Pro Ala Ser Gly Val Asn His Gln His 
    50                  55                  60                  


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met 
65                  70                  75                  80  


Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala 
                85                  90                  95      


Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe 
            100                 105                 110         


Val Cys Pro Trp Cys Ala Ser Gln Gln Gly Val Ser His Ala Gln Leu 
        115                 120                 125             


Pro Ala Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys Val Cys 
    130                 135                 140                 


Cys Lys Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser Ala Glu 
145                 150                 155                 160 


Asp Leu Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe Val 
                165                 170                 175     


Cys Pro Trp Cys Ala Thr Asn Gln Gly Gln Ala Gln Pro Ala Thr Ala 
            180                 185                 190         


Asp Tyr Tyr Ile Val Thr Cys Cys His Thr Cys Asn Thr Thr Val Arg 
        195                 200                 205             


Leu Cys Val Asn Ser Thr Ala Ser Asp Leu Arg Thr Ile Gln Gln Leu 
    210                 215                 220                 


Leu Met Gly Thr Val Asn Ile Val Cys Pro Ser Cys Ala Gln Leu Met 
225                 230                 235                 240 


His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro 
                245                 250                 255     


Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Met His Gly Pro 
            260                 265                 270         


Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu 
        275                 280                 285             


Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Met His Gly Pro Arg 
    290                 295                 300                 


Glu Thr Leu Gln Glu Ile Val Leu His Leu Glu Pro Gln Asn Glu Leu 
305                 310                 315                 320 


Asp Pro Val Asp Leu Leu Cys Tyr Glu Gln Leu Met Arg Gly His Lys 
                325                 330                 335     


Pro Thr Leu Lys Glu Tyr Ile Leu Asp Leu Tyr Pro Glu Pro Thr Asp 
            340                 345                 350         


Leu Tyr Cys Tyr Glu Gln Leu Ser 
        355                 360 


<210>  51
<211>  1224
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide for antigen E7 of HPV16, 18, 33 and 45 full


<220>
<221>  CDS
<222>  (1)..(1224)

<400>  51
gaa gac gaa atc gac ggc cct gcg ggc cag gct gaa cca gat cgt gct         48
Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala           
1               5                   10                  15                

cac tac aac atc gta act ttt tgc tgt aag tgc gat agc act ctg cgt         96
His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg           
            20                  25                  30                    

ctg tgc gta cag tct act cac gtt gat atc cgc act ctg gaa gat ctg        144
Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu           
        35                  40                  45                        

ctg atg ggt acc ctg ggt atc gtc tgc cca atc tgc tct caa aag cct        192
Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro           
    50                  55                  60                            

gct tct ggt gtt aac cat cag cac ctg ccg gct cgt cgc gct gaa cca        240
Ala Ser Gly Val Asn His Gln His Leu Pro Ala Arg Arg Ala Glu Pro           
65                  70                  75                  80            

cag cgt cat acc atg ctg tgc atg tgt tgc aaa tgc gag gct cgc atc        288
Gln Arg His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile           
                85                  90                  95                

gaa ctg gtt gtt gaa tcc agc gct gac gac ctg cgt gcg ttt cag caa        336
Glu Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln           
            100                 105                 110                   

ctg ttc ctg aac acg ctg tct ttt gtt tgt ccg tgg tgt gcc tcc cag        384
Leu Phe Leu Asn Thr Leu Ser Phe Val Cys Pro Trp Cys Ala Ser Gln           
        115                 120                 125                       

cag gag aac gat gaa gcg gat ggc gtg tcc cac gcg cag ctg ccg gca        432
Gln Glu Asn Asp Glu Ala Asp Gly Val Ser His Ala Gln Leu Pro Ala           
    130                 135                 140                           

cgt cgt gca gaa ccg cag cgc cac aag att ctg tgc gtt tgc tgt aaa        480
Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys Val Cys Cys Lys           
145                 150                 155                 160           

tgt gat ggc cgt atc gaa ctg act gtg gaa tcc tcc gcg gaa gat ctg        528
Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser Ala Glu Asp Leu           
                165                 170                 175               

cgt acg ctg cag cag ctg ttc ctg tct acc ctg tct ttc gtg tgc ccg        576
Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe Val Cys Pro           
            180                 185                 190                   

tgg tgc gcc acc aat caa tcg gat gaa gat gaa ggt ctg gat cgt ccg        624
Trp Cys Ala Thr Asn Gln Ser Asp Glu Asp Glu Gly Leu Asp Arg Pro           
        195                 200                 205                       

gat ggt caa gcg cag ccg gcg act gca gat tac tat atc gtc act tgt        672
Asp Gly Gln Ala Gln Pro Ala Thr Ala Asp Tyr Tyr Ile Val Thr Cys           
    210                 215                 220                           

tgc cac acc tgc aat acc acc gtg cgt ctg tgt gtg aac agc acg gcg        720
Cys His Thr Cys Asn Thr Thr Val Arg Leu Cys Val Asn Ser Thr Ala           
225                 230                 235                 240           

agc gac ctg cgc acg atc caa cag ttg ttg atg ggc acc gtg aat atc        768
Ser Asp Leu Arg Thr Ile Gln Gln Leu Leu Met Gly Thr Val Asn Ile           
                245                 250                 255               

gtc tgc cca agc tgt gct cag ttg atg cac ggc gac acc ccg acc ctg        816
Val Cys Pro Ser Cys Ala Gln Leu Met His Gly Asp Thr Pro Thr Leu           
            260                 265                 270                   

cac gaa tac atg ctg gac ctg cag ccg gaa acc acg gat ctg tat tgt        864
His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Cys           
        275                 280                 285                       

tat gaa cag ctg aac gat agc agc gag gaa atg cac ggt ccg aaa gca        912
Tyr Glu Gln Leu Asn Asp Ser Ser Glu Glu Met His Gly Pro Lys Ala           
    290                 295                 300                           

act ctg cag gac att gtg ctg cat ctg gag cca cag aac gaa atc ccg        960
Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu Ile Pro           
305                 310                 315                 320           

gtt gat ctg ctg tgc cac gag caa ctg agc gat tcc gaa gag gaa aac       1008
Val Asp Leu Leu Cys His Glu Gln Leu Ser Asp Ser Glu Glu Glu Asn           
                325                 330                 335               

gac gaa att gat atg cat ggt ccg cgc gag acc ctg caa gaa atc gtc       1056
Asp Glu Ile Asp Met His Gly Pro Arg Glu Thr Leu Gln Glu Ile Val           
            340                 345                 350                   

ctg cac ctg gaa ccg caa aac gaa ctg gac cct gta gac ctg ctg tgc       1104
Leu His Leu Glu Pro Gln Asn Glu Leu Asp Pro Val Asp Leu Leu Cys           
        355                 360                 365                       

tac gaa cag ctg tcc gaa tct gaa gaa atg cgt ggt cac aaa ccg acg       1152
Tyr Glu Gln Leu Ser Glu Ser Glu Glu Met Arg Gly His Lys Pro Thr           
    370                 375                 380                           

ctg aaa gag tac atc ctg gac ctg tac ccg gaa cct acg gat ctg tac       1200
Leu Lys Glu Tyr Ile Leu Asp Leu Tyr Pro Glu Pro Thr Asp Leu Tyr           
385                 390                 395                 400           

tgt tat gaa caa ctg agc gat agc                                       1224
Cys Tyr Glu Gln Leu Ser Asp Ser                                           
                405                                                       


<210>  52
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52

Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala 
1               5                   10                  15      


His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg 
            20                  25                  30          


Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu 
        35                  40                  45              


Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro 
    50                  55                  60                  


Ala Ser Gly Val Asn His Gln His Leu Pro Ala Arg Arg Ala Glu Pro 
65                  70                  75                  80  


Gln Arg His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile 
                85                  90                  95      


Glu Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln 
            100                 105                 110         


Leu Phe Leu Asn Thr Leu Ser Phe Val Cys Pro Trp Cys Ala Ser Gln 
        115                 120                 125             


Gln Glu Asn Asp Glu Ala Asp Gly Val Ser His Ala Gln Leu Pro Ala 
    130                 135                 140                 


Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys Val Cys Cys Lys 
145                 150                 155                 160 


Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser Ala Glu Asp Leu 
                165                 170                 175     


Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe Val Cys Pro 
            180                 185                 190         


Trp Cys Ala Thr Asn Gln Ser Asp Glu Asp Glu Gly Leu Asp Arg Pro 
        195                 200                 205             


Asp Gly Gln Ala Gln Pro Ala Thr Ala Asp Tyr Tyr Ile Val Thr Cys 
    210                 215                 220                 


Cys His Thr Cys Asn Thr Thr Val Arg Leu Cys Val Asn Ser Thr Ala 
225                 230                 235                 240 


Ser Asp Leu Arg Thr Ile Gln Gln Leu Leu Met Gly Thr Val Asn Ile 
                245                 250                 255     


Val Cys Pro Ser Cys Ala Gln Leu Met His Gly Asp Thr Pro Thr Leu 
            260                 265                 270         


His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Cys 
        275                 280                 285             


Tyr Glu Gln Leu Asn Asp Ser Ser Glu Glu Met His Gly Pro Lys Ala 
    290                 295                 300                 


Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu Ile Pro 
305                 310                 315                 320 


Val Asp Leu Leu Cys His Glu Gln Leu Ser Asp Ser Glu Glu Glu Asn 
                325                 330                 335     


Asp Glu Ile Asp Met His Gly Pro Arg Glu Thr Leu Gln Glu Ile Val 
            340                 345                 350         


Leu His Leu Glu Pro Gln Asn Glu Leu Asp Pro Val Asp Leu Leu Cys 
        355                 360                 365             


Tyr Glu Gln Leu Ser Glu Ser Glu Glu Met Arg Gly His Lys Pro Thr 
    370                 375                 380                 


Leu Lys Glu Tyr Ile Leu Asp Leu Tyr Pro Glu Pro Thr Asp Leu Tyr 
385                 390                 395                 400 


Cys Tyr Glu Gln Leu Ser Asp Ser 
                405             


<210>  53
<211>  1080
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide for antigen E7 of HPV16, 18, 45 and 58 
       acidic-deleted


<220>
<221>  CDS
<222>  (1)..(1080)

<400>  53
ggt cag gcg gaa ccg gat cgc gcg cac tac aac atc gtt act ttt tgt         48
Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys           
1               5                   10                  15                

tgc aaa tgt gat tcc act ctg cgc ctg tgt gtg caa tcc acc cac gta         96
Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val           
            20                  25                  30                    

gac atc cgc act ctg gaa gac ctg ctg atg ggt acc ctg ggt att gtt        144
Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val           
        35                  40                  45                        

tgt ccg att tgc tcc cag aag ccg gcg tct ggc gtt aac cac caa cac        192
Cys Pro Ile Cys Ser Gln Lys Pro Ala Ser Gly Val Asn His Gln His           
    50                  55                  60                            

ctg ccg gcg cgt cgc gca gag ccg cag cgt cac acc atg ctg tgc atg        240
Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met           
65                  70                  75                  80            

tgc tgt aaa tgt gag gcc cgt att gaa ctg gtc gtt gag tct agc gcc        288
Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala           
                85                  90                  95                

gac gat ctg cgt gcg ttt cag cag ctg ttc ctg aac acg ctg agc ttc        336
Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe           
            100                 105                 110                   

gtt tgc ccg tgg tgt gct agc cag cag ggc gtg tct cac gct cag ctg        384
Val Cys Pro Trp Cys Ala Ser Gln Gln Gly Val Ser His Ala Gln Leu           
        115                 120                 125                       

ccg gca cgt cgt gct gag cct cag cgt cac aaa atc ctg tgc gtg tgc        432
Pro Ala Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys Val Cys           
    130                 135                 140                           

tgc aaa tgc gat ggc cgc atc gaa ctg acc gtg gaa tct agc gca gaa        480
Cys Lys Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser Ala Glu           
145                 150                 155                 160           

gac ctg cgt acg ctg cag caa ctg ttc ctg agc acg ctg tcc ttc gta        528
Asp Leu Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe Val           
                165                 170                 175               

tgc cct tgg tgc gca act aat cag ggc cag gcg cag cca gcg acg gcc        576
Cys Pro Trp Cys Ala Thr Asn Gln Gly Gln Ala Gln Pro Ala Thr Ala           
            180                 185                 190                   

aat tac tac atc gtt acc tgt tgc tat acg tgc gat act acc gtc cgt        624
Asn Tyr Tyr Ile Val Thr Cys Cys Tyr Thr Cys Asp Thr Thr Val Arg           
        195                 200                 205                       

ctg tgc att aac agc acc acc acg gac gtg cgt acc ctg caa cag ctg        672
Leu Cys Ile Asn Ser Thr Thr Thr Asp Val Arg Thr Leu Gln Gln Leu           
    210                 215                 220                           

ctg atg ggt acc tgc acg att gtt tgt ccg agc tgt gca caa caa atg        720
Leu Met Gly Thr Cys Thr Ile Val Cys Pro Ser Cys Ala Gln Gln Met           
225                 230                 235                 240           

cac ggt gac acc ccg acc ctg cac gaa tac atg ctg gac ctg cag cca        768
His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro           
                245                 250                 255               

gaa acc acc gat ctg tac tgt tac gaa cag ctg aac atg cat ggc cca        816
Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Met His Gly Pro           
            260                 265                 270                   

aaa gct act ctg cag gat atc gtc ctg cat ctg gaa cca cag aac gaa        864
Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu           
        275                 280                 285                       

atc ccg gta gat ctg ctg tgc cat gag cag ctg atg cat ggt ccg cgt        912
Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Met His Gly Pro Arg           
    290                 295                 300                           

gaa acc ctg cag gaa atc gtt ctg cac ctg gaa ccg caa aac gaa ctg        960
Glu Thr Leu Gln Glu Ile Val Leu His Leu Glu Pro Gln Asn Glu Leu           
305                 310                 315                 320           

gac ccg gtt gac ctg ctg tgc tat gaa cag ctg atg cgc ggt aat aac       1008
Asp Pro Val Asp Leu Leu Cys Tyr Glu Gln Leu Met Arg Gly Asn Asn           
                325                 330                 335               

ccg acc ttg cgt gag tat atc ttg gac ctg cac ccg gag ccg acc gat       1056
Pro Thr Leu Arg Glu Tyr Ile Leu Asp Leu His Pro Glu Pro Thr Asp           
            340                 345                 350                   

ctg ttc tgt tac gaa cag ctg tgc                                       1080
Leu Phe Cys Tyr Glu Gln Leu Cys                                           
        355                 360                                           


<210>  54
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54

Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys 
1               5                   10                  15      


Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val 
            20                  25                  30          


Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val 
        35                  40                  45              


Cys Pro Ile Cys Ser Gln Lys Pro Ala Ser Gly Val Asn His Gln His 
    50                  55                  60                  


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met 
65                  70                  75                  80  


Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala 
                85                  90                  95      


Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe 
            100                 105                 110         


Val Cys Pro Trp Cys Ala Ser Gln Gln Gly Val Ser His Ala Gln Leu 
        115                 120                 125             


Pro Ala Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys Val Cys 
    130                 135                 140                 


Cys Lys Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser Ala Glu 
145                 150                 155                 160 


Asp Leu Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe Val 
                165                 170                 175     


Cys Pro Trp Cys Ala Thr Asn Gln Gly Gln Ala Gln Pro Ala Thr Ala 
            180                 185                 190         


Asn Tyr Tyr Ile Val Thr Cys Cys Tyr Thr Cys Asp Thr Thr Val Arg 
        195                 200                 205             


Leu Cys Ile Asn Ser Thr Thr Thr Asp Val Arg Thr Leu Gln Gln Leu 
    210                 215                 220                 


Leu Met Gly Thr Cys Thr Ile Val Cys Pro Ser Cys Ala Gln Gln Met 
225                 230                 235                 240 


His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro 
                245                 250                 255     


Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Met His Gly Pro 
            260                 265                 270         


Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu 
        275                 280                 285             


Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Met His Gly Pro Arg 
    290                 295                 300                 


Glu Thr Leu Gln Glu Ile Val Leu His Leu Glu Pro Gln Asn Glu Leu 
305                 310                 315                 320 


Asp Pro Val Asp Leu Leu Cys Tyr Glu Gln Leu Met Arg Gly Asn Asn 
                325                 330                 335     


Pro Thr Leu Arg Glu Tyr Ile Leu Asp Leu His Pro Glu Pro Thr Asp 
            340                 345                 350         


Leu Phe Cys Tyr Glu Gln Leu Cys 
        355                 360 


<210>  55
<211>  1227
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide for antigen E7 of HPV16, 18, 45 and 58  full


<220>
<221>  CDS
<222>  (1)..(1227)

<400>  55
gaa gac gaa atc gac ggc cct gcg ggc cag gct gaa cca gat cgt gct         48
Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala           
1               5                   10                  15                

cac tac aac atc gta act ttt tgc tgt aag tgc gat agc act ctg cgt         96
His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg           
            20                  25                  30                    

ctg tgc gta cag tct act cac gtt gat atc cgc act ctg gaa gat ctg        144
Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu           
        35                  40                  45                        

ctg atg ggt acc ctg ggt atc gtc tgc cca atc tgc tct caa aag cct        192
Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro           
    50                  55                  60                            

gct tct ggt gtt aac cat cag cac ctg ccg gct cgt cgc gct gaa cca        240
Ala Ser Gly Val Asn His Gln His Leu Pro Ala Arg Arg Ala Glu Pro           
65                  70                  75                  80            

cag cgt cat acc atg ctg tgc atg tgt tgc aaa tgc gag gct cgc atc        288
Gln Arg His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile           
                85                  90                  95                

gaa ctg gtt gtt gaa tcc agc gct gac gac ctg cgt gcg ttt cag caa        336
Glu Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln           
            100                 105                 110                   

ctg ttc ctg aac acg ctg tct ttt gtt tgt ccg tgg tgt gcc tcc cag        384
Leu Phe Leu Asn Thr Leu Ser Phe Val Cys Pro Trp Cys Ala Ser Gln           
        115                 120                 125                       

cag gag aac gat gaa gcg gat ggc gtg tcc cac gcg cag ctg ccg gca        432
Gln Glu Asn Asp Glu Ala Asp Gly Val Ser His Ala Gln Leu Pro Ala           
    130                 135                 140                           

cgt cgt gca gaa ccg cag cgc cac aag att ctg tgc gtt tgc tgt aaa        480
Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys Val Cys Cys Lys           
145                 150                 155                 160           

tgt gat ggc cgt atc gaa ctg act gtg gaa tcc tcc gcg gaa gat ctg        528
Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser Ala Glu Asp Leu           
                165                 170                 175               

cgt acg ctg cag cag ctg ttc ctg tct acc ctg tct ttc gtg tgc ccg        576
Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe Val Cys Pro           
            180                 185                 190                   

tgg tgc gcc acc aat caa tcc gac gag gac gaa atc ggc ctg gac cgt        624
Trp Cys Ala Thr Asn Gln Ser Asp Glu Asp Glu Ile Gly Leu Asp Arg           
        195                 200                 205                       

cct gat ggc cag gcc cag ccg gca acg gcg aac tat tac att gtg acc        672
Pro Asp Gly Gln Ala Gln Pro Ala Thr Ala Asn Tyr Tyr Ile Val Thr           
    210                 215                 220                           

tgc tgc tat acg tgc gat acc acg gtc cgt ctg tgc att aac tct acc        720
Cys Cys Tyr Thr Cys Asp Thr Thr Val Arg Leu Cys Ile Asn Ser Thr           
225                 230                 235                 240           

acc acg gat gtt cgc acg ctg cag caa ctg ctg atg ggt acc tgt acc        768
Thr Thr Asp Val Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Cys Thr           
                245                 250                 255               

att gtt tgc ccg tct tgt gcc cag cag atg cac ggc gac acc ccg acc        816
Ile Val Cys Pro Ser Cys Ala Gln Gln Met His Gly Asp Thr Pro Thr           
            260                 265                 270                   

ctg cac gaa tac atg ctg gac ctg cag ccg gaa acc acg gat ctg tat        864
Leu His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr           
        275                 280                 285                       

tgt tat gaa cag ctg aac gat agc agc gag gaa atg cac ggt ccg aaa        912
Cys Tyr Glu Gln Leu Asn Asp Ser Ser Glu Glu Met His Gly Pro Lys           
    290                 295                 300                           

gca act ctg cag gac att gtg ctg cat ctg gag cca cag aac gaa atc        960
Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu Ile           
305                 310                 315                 320           

ccg gtt gat ctg ctg tgc cac gag caa ctg agc gat tcc gaa gag gaa       1008
Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser Asp Ser Glu Glu Glu           
                325                 330                 335               

aac gac gaa att gat atg cat ggt ccg cgc gag acc ctg caa gaa atc       1056
Asn Asp Glu Ile Asp Met His Gly Pro Arg Glu Thr Leu Gln Glu Ile           
            340                 345                 350                   

gtc ctg cac ctg gaa ccg caa aac gaa ctg gac cct gta gac ctg ctg       1104
Val Leu His Leu Glu Pro Gln Asn Glu Leu Asp Pro Val Asp Leu Leu           
        355                 360                 365                       

tgc tac gaa cag ctg tcc gaa tct gaa gaa atg cgc ggt aac aat ccg       1152
Cys Tyr Glu Gln Leu Ser Glu Ser Glu Glu Met Arg Gly Asn Asn Pro           
    370                 375                 380                           

acc ctg cgc gag tac att ctg gac ttg cat ccg gaa ccg acg gac ctg       1200
Thr Leu Arg Glu Tyr Ile Leu Asp Leu His Pro Glu Pro Thr Asp Leu           
385                 390                 395                 400           

ttc tgt tac gag cag ctg tgt gac agc                                   1227
Phe Cys Tyr Glu Gln Leu Cys Asp Ser                                       
                405                                                       


<210>  56
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56

Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala 
1               5                   10                  15      


His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg 
            20                  25                  30          


Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu 
        35                  40                  45              


Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro 
    50                  55                  60                  


Ala Ser Gly Val Asn His Gln His Leu Pro Ala Arg Arg Ala Glu Pro 
65                  70                  75                  80  


Gln Arg His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile 
                85                  90                  95      


Glu Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln 
            100                 105                 110         


Leu Phe Leu Asn Thr Leu Ser Phe Val Cys Pro Trp Cys Ala Ser Gln 
        115                 120                 125             


Gln Glu Asn Asp Glu Ala Asp Gly Val Ser His Ala Gln Leu Pro Ala 
    130                 135                 140                 


Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys Val Cys Cys Lys 
145                 150                 155                 160 


Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser Ala Glu Asp Leu 
                165                 170                 175     


Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe Val Cys Pro 
            180                 185                 190         


Trp Cys Ala Thr Asn Gln Ser Asp Glu Asp Glu Ile Gly Leu Asp Arg 
        195                 200                 205             


Pro Asp Gly Gln Ala Gln Pro Ala Thr Ala Asn Tyr Tyr Ile Val Thr 
    210                 215                 220                 


Cys Cys Tyr Thr Cys Asp Thr Thr Val Arg Leu Cys Ile Asn Ser Thr 
225                 230                 235                 240 


Thr Thr Asp Val Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Cys Thr 
                245                 250                 255     


Ile Val Cys Pro Ser Cys Ala Gln Gln Met His Gly Asp Thr Pro Thr 
            260                 265                 270         


Leu His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr 
        275                 280                 285             


Cys Tyr Glu Gln Leu Asn Asp Ser Ser Glu Glu Met His Gly Pro Lys 
    290                 295                 300                 


Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu Ile 
305                 310                 315                 320 


Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser Asp Ser Glu Glu Glu 
                325                 330                 335     


Asn Asp Glu Ile Asp Met His Gly Pro Arg Glu Thr Leu Gln Glu Ile 
            340                 345                 350         


Val Leu His Leu Glu Pro Gln Asn Glu Leu Asp Pro Val Asp Leu Leu 
        355                 360                 365             


Cys Tyr Glu Gln Leu Ser Glu Ser Glu Glu Met Arg Gly Asn Asn Pro 
    370                 375                 380                 


Thr Leu Arg Glu Tyr Ile Leu Asp Leu His Pro Glu Pro Thr Asp Leu 
385                 390                 395                 400 


Phe Cys Tyr Glu Gln Leu Cys Asp Ser 
                405                 


<210>  57
<211>  5670
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide encoding chimeric CyaA delta 93+ antigen HPV16, HPV18 
       and HPV45 acidic-deleted


<220>
<221>  CDS
<222>  (1)..(5670)

<400>  57
atg cag cag tcc cat cag gcc ggt tac gca aac gca gcc gat cgt gaa         48
Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu           
1               5                   10                  15                

tct ggt atc ccg gca gcg gtt ctg gat ggt att aag gca gtt gcc aaa         96
Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys           
            20                  25                  30                    

gag aag aac gct acc ctg atg ttc cgt ctg gtc aac cca cac tct act        144
Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr           
        35                  40                  45                        

tcc ctg atc gcg gaa ggt gtg gcg acc aaa ggc ctg ggt gtg cac gcc        192
Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala           
    50                  55                  60                            

aaa agc agc gac tgg ggt ctg cag gca ggt tat att ccg gtg aac ccg        240
Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro           
65                  70                  75                  80            

aat ctg tct aaa ctg ttc ggt cgt gcc ccg gag gtg atc gca cgt gca        288
Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala           
                85                  90                  95                

gac aac gat gtc aac tct tct ctg gcg cat ggt cac acc gcg gtt gat        336
Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp           
            100                 105                 110                   

ctg acc ctg tcc aaa gaa cgc ctg gat tac ctg cgt cag gcg ggc ctg        384
Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu           
        115                 120                 125                       

gtg acg ggc atg gcc gac ggt gtt gta gcg agc aac cac gcg ggt tat        432
Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr           
    130                 135                 140                           

gaa caa ttt gag ttt cgc gtt aaa gag acc tct gac ggt cgt tac gcg        480
Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala           
145                 150                 155                 160           

gtg cag tac cgc cgc aaa ggt ggc gat gac ttt gaa gct gtc aaa gtg        528
Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val           
                165                 170                 175               

atc ggt aac gct gct gga att ccg ctg acc gcg gat atc gac atg ttt        576
Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe           
            180                 185                 190                   

gcc atc atg cct cac ctg tcc aac ttt cgc gat tcc gca cgc agc tct        624
Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser           
        195                 200                 205                       

gtg acg tct ggt gat tcc gtc act gac tac ctg gct cgt acc cgt cgt        672
Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg           
    210                 215                 220                           

gcg gcc tct ggt cag gcg gaa ccg gat cgc gcg cac tac aac atc gtt        720
Ala Ala Ser Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val           
225                 230                 235                 240           

act ttt tgt tgc aaa tgt gat tcc act ctg cgc ctg tgt gtg caa tcc        768
Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser           
                245                 250                 255               

acc cac gta gac att cgc act ctg gaa gac ctg ctg atg ggt acc ctt        816
Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu           
            260                 265                 270                   

ggt att gtt tgt ccg att tgc tcc cag aag ccg gcg tct ggc gtt aac        864
Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro Ala Ser Gly Val Asn           
        275                 280                 285                       

cac caa cac ctg ccg gcg cgt cgc gca gag ccg cag cgt cac acc atg        912
His Gln His Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met           
    290                 295                 300                           

ctg tgc atg tgc tgt aaa tgt gag gcc cgt atc gag ctg gtc gtt gag        960
Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu           
305                 310                 315                 320           

tct agc gcc gac gat ctg cgt gcg ttt cag cag ctg ttc ctg aac acg       1008
Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr           
                325                 330                 335               

ctg agc ttc gtt tgc ccg tgg tgt gct agc cag cag ggc gtg tct cac       1056
Leu Ser Phe Val Cys Pro Trp Cys Ala Ser Gln Gln Gly Val Ser His           
            340                 345                 350                   

gct cag ctg ccg gca cgt cgt gct gag cct cag cgt cac aaa atc ctg       1104
Ala Gln Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu           
        355                 360                 365                       

tgc gtg tgc tgc aaa tgc gat ggc cgc atc gaa ctg acc gtg gaa tct       1152
Cys Val Cys Cys Lys Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser           
    370                 375                 380                           

agc gca gaa gac ctg cgt acg ctg cag caa ctg ttc ctg agc acg ctg       1200
Ser Ala Glu Asp Leu Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu           
385                 390                 395                 400           

tcc ttc gta tgc cct tgg tgc gca act aat cag atg cac ggt gac acc       1248
Ser Phe Val Cys Pro Trp Cys Ala Thr Asn Gln Met His Gly Asp Thr           
                405                 410                 415               

ccg acc ctg cac gaa tac atg ctg gac ctg cag cca gaa acc acc gat       1296
Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp           
            420                 425                 430                   

ctg tac tgt tac gaa cag ctg aac atg cat ggc cca aaa gct act ctg       1344
Leu Tyr Cys Tyr Glu Gln Leu Asn Met His Gly Pro Lys Ala Thr Leu           
        435                 440                 445                       

cag gat atc gtc ctg cat ctg gaa cca cag aac gaa atc ccg gta gat       1392
Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu Ile Pro Val Asp           
    450                 455                 460                           

ctg ctg tgc cat gag cag ctg atg cat ggt ccg cgt gaa acc ctg cag       1440
Leu Leu Cys His Glu Gln Leu Met His Gly Pro Arg Glu Thr Leu Gln           
465                 470                 475                 480           

gaa atc gtt ctg cac ctg gaa ccg caa aac gaa ctg gac ccg gtt gac       1488
Glu Ile Val Leu His Leu Glu Pro Gln Asn Glu Leu Asp Pro Val Asp           
                485                 490                 495               

ctg ctg tgc tat gaa cag ctg gaa tcc cag atg ctg act cgt ggc cag       1536
Leu Leu Cys Tyr Glu Gln Leu Glu Ser Gln Met Leu Thr Arg Gly Gln           
            500                 505                 510                   

ctg aaa gaa tac atc ggc caa cag cgt ggc gaa ggc tac gtt ttc tac       1584
Leu Lys Glu Tyr Ile Gly Gln Gln Arg Gly Glu Gly Tyr Val Phe Tyr           
        515                 520                 525                       

gag aat cgt gct tac ggc gtt gcg ggc aaa tcc ctg ttc gac gat ggt       1632
Glu Asn Arg Ala Tyr Gly Val Ala Gly Lys Ser Leu Phe Asp Asp Gly           
    530                 535                 540                           

ctg ggc gct gca ccg ggc gtt ccg agc ggc cgt tct aaa ttc agc ccg       1680
Leu Gly Ala Ala Pro Gly Val Pro Ser Gly Arg Ser Lys Phe Ser Pro           
545                 550                 555                 560           

gac gta ctg gaa act gtg ccg gct tcc ccg ggc ctg cgc cgt ccg tcc       1728
Asp Val Leu Glu Thr Val Pro Ala Ser Pro Gly Leu Arg Arg Pro Ser           
                565                 570                 575               

ctg ggc gca gtc gaa cgt cag gac tcc ggc tac gat tcc ctg gat ggc       1776
Leu Gly Ala Val Glu Arg Gln Asp Ser Gly Tyr Asp Ser Leu Asp Gly           
            580                 585                 590                   

gtt ggc tcc cgc tcc ttc tcc ctg ggc gag gtt tct gac atg gct gcg       1824
Val Gly Ser Arg Ser Phe Ser Leu Gly Glu Val Ser Asp Met Ala Ala           
        595                 600                 605                       

gtg gaa gcg gca gag ctg gaa atg acc cgt caa gtg ctg cac gcg ggc       1872
Val Glu Ala Ala Glu Leu Glu Met Thr Arg Gln Val Leu His Ala Gly           
    610                 615                 620                           

gca cgt cag gac gat gct gag ccg ggc gtg tcc ggt gcg tct gca cac       1920
Ala Arg Gln Asp Asp Ala Glu Pro Gly Val Ser Gly Ala Ser Ala His           
625                 630                 635                 640           

tgg ggt caa cgt gcc ctg cag ggt gct caa gct gtc gcg gca gcg cag       1968
Trp Gly Gln Arg Ala Leu Gln Gly Ala Gln Ala Val Ala Ala Ala Gln           
                645                 650                 655               

cgt ctg gta cat gcg atc gca ctg atg acc cag ttc ggt cgc gca ggt       2016
Arg Leu Val His Ala Ile Ala Leu Met Thr Gln Phe Gly Arg Ala Gly           
            660                 665                 670                   

tct acc aac act cct cag gaa gca gct agc ctg tct gct gct gtt ttc       2064
Ser Thr Asn Thr Pro Gln Glu Ala Ala Ser Leu Ser Ala Ala Val Phe           
        675                 680                 685                       

ggt ctg ggc gaa gcg tct tct gcg gtt gca gaa acc gtg agc ggt ttc       2112
Gly Leu Gly Glu Ala Ser Ser Ala Val Ala Glu Thr Val Ser Gly Phe           
    690                 695                 700                           

ttc cgt ggt tct agc cgc tgg gcg ggt ggt ttt ggt gta gca ggt ggc       2160
Phe Arg Gly Ser Ser Arg Trp Ala Gly Gly Phe Gly Val Ala Gly Gly           
705                 710                 715                 720           

gct atg gcc ctg ggt ggc ggt atc gcg gct gct gtc ggc gca ggt atg       2208
Ala Met Ala Leu Gly Gly Gly Ile Ala Ala Ala Val Gly Ala Gly Met           
                725                 730                 735               

agc ctg acc gac gat gct cct gcg ggc cag aaa gcc gca gct ggc gct       2256
Ser Leu Thr Asp Asp Ala Pro Ala Gly Gln Lys Ala Ala Ala Gly Ala           
            740                 745                 750                   

gaa atc gcg ctg cag ctg act ggt ggt acc gtt gaa ctg gct agc tct       2304
Glu Ile Ala Leu Gln Leu Thr Gly Gly Thr Val Glu Leu Ala Ser Ser           
        755                 760                 765                       

atc gcg ctg gct ctg gca gcg gca cgt ggc gtg act tct ggc ctg caa       2352
Ile Ala Leu Ala Leu Ala Ala Ala Arg Gly Val Thr Ser Gly Leu Gln           
    770                 775                 780                           

gtc gcc ggt gcc tct gcg ggc gct gct gcg ggc gct ctg gca gct gca       2400
Val Ala Gly Ala Ser Ala Gly Ala Ala Ala Gly Ala Leu Ala Ala Ala           
785                 790                 795                 800           

ctg tcc ccc atg gaa atc tac ggt ctg gta cag cag tct cac tac gca       2448
Leu Ser Pro Met Glu Ile Tyr Gly Leu Val Gln Gln Ser His Tyr Ala           
                805                 810                 815               

gac cag ctg gat aaa ctg gcg cag gag tct tct gca tac ggt tac gaa       2496
Asp Gln Leu Asp Lys Leu Ala Gln Glu Ser Ser Ala Tyr Gly Tyr Glu           
            820                 825                 830                   

ggc gac gca ctg ctg gcg cag ctg tat cgt gac aaa act gct gct gaa       2544
Gly Asp Ala Leu Leu Ala Gln Leu Tyr Arg Asp Lys Thr Ala Ala Glu           
        835                 840                 845                       

ggt gct gtg gca ggc gtt tct gcg gta ctg tct acc gtt ggc gct gcg       2592
Gly Ala Val Ala Gly Val Ser Ala Val Leu Ser Thr Val Gly Ala Ala           
    850                 855                 860                           

gtt tct att gcg gct gcc gca tcc gtt gta ggt gcg ccg gtt gct gta       2640
Val Ser Ile Ala Ala Ala Ala Ser Val Val Gly Ala Pro Val Ala Val           
865                 870                 875                 880           

gtt acc tct ctg ctg act ggt gca ctg aac ggt atc ctg cgt ggt gtt       2688
Val Thr Ser Leu Leu Thr Gly Ala Leu Asn Gly Ile Leu Arg Gly Val           
                885                 890                 895               

cag cag cct att atc gaa aaa ctg gcg aat gat tat gcc cgt aaa atc       2736
Gln Gln Pro Ile Ile Glu Lys Leu Ala Asn Asp Tyr Ala Arg Lys Ile           
            900                 905                 910                   

gac gaa ctg ggc ggt ccg cag gct tat ttt gaa aaa aac ctg cag gcg       2784
Asp Glu Leu Gly Gly Pro Gln Ala Tyr Phe Glu Lys Asn Leu Gln Ala           
        915                 920                 925                       

cgc cac gaa cag ctg gca aac agc gac ggc ctg cgc aaa atg ctg gca       2832
Arg His Glu Gln Leu Ala Asn Ser Asp Gly Leu Arg Lys Met Leu Ala           
    930                 935                 940                           

gac ctg caa gct ggt tgg aac gcg tct tct gtg atc ggc gtg cag acc       2880
Asp Leu Gln Ala Gly Trp Asn Ala Ser Ser Val Ile Gly Val Gln Thr           
945                 950                 955                 960           

acc gaa att agc aaa tct gcg ctg gaa ctg gct gca att act ggc aac       2928
Thr Glu Ile Ser Lys Ser Ala Leu Glu Leu Ala Ala Ile Thr Gly Asn           
                965                 970                 975               

gcg gat aac ctg aaa agc gtt gat gtt ttt gtc gat cgc ttc gtt cag       2976
Ala Asp Asn Leu Lys Ser Val Asp Val Phe Val Asp Arg Phe Val Gln           
            980                 985                 990                   

ggc gag cgc gtt gct ggt cag ccg  gtt gtt ctg gac gtt  gcg gca ggc     3024
Gly Glu Arg Val Ala Gly Gln Pro  Val Val Leu Asp Val  Ala Ala Gly         
        995                 1000                 1005                     

ggc atc  gac atc gct agc cgc  aag ggc gag cgt ccg  gct ctg act        3069
Gly Ile  Asp Ile Ala Ser Arg  Lys Gly Glu Arg Pro  Ala Leu Thr            
    1010                 1015                 1020                        

ttc att  acc ccg ctg gca gct  ccg ggt gaa gaa cag  cgt cgc cgt        3114
Phe Ile  Thr Pro Leu Ala Ala  Pro Gly Glu Glu Gln  Arg Arg Arg            
    1025                 1030                 1035                        

acc aag  act ggt aaa agc gag  ttc acc acc ttc gtg  gaa atc gta        3159
Thr Lys  Thr Gly Lys Ser Glu  Phe Thr Thr Phe Val  Glu Ile Val            
    1040                 1045                 1050                        

ggt aaa  cag gac cgc tgg cgt  att cgc gac ggt gcg  gcg gac acc        3204
Gly Lys  Gln Asp Arg Trp Arg  Ile Arg Asp Gly Ala  Ala Asp Thr            
    1055                 1060                 1065                        

acc atc  gac ctg gca aaa gtt  gtt tcc caa ctg gta  gat gct aac        3249
Thr Ile  Asp Leu Ala Lys Val  Val Ser Gln Leu Val  Asp Ala Asn            
    1070                 1075                 1080                        

ggc gtg  ctg aaa cat tct att  aaa ctg gat gta atc  ggc ggt gac        3294
Gly Val  Leu Lys His Ser Ile  Lys Leu Asp Val Ile  Gly Gly Asp            
    1085                 1090                 1095                        

ggc gat  gac gtt gta ctg gcg  aac gcg tct cgt atc  cac tat gac        3339
Gly Asp  Asp Val Val Leu Ala  Asn Ala Ser Arg Ile  His Tyr Asp            
    1100                 1105                 1110                        

ggc ggc  gca ggt acc aac acg  gtt tcc tac gca gcg  ctg ggc cgc        3384
Gly Gly  Ala Gly Thr Asn Thr  Val Ser Tyr Ala Ala  Leu Gly Arg            
    1115                 1120                 1125                        

cag gat  tcc atc act gtt agc  gcc gat ggc gaa cgt  ttc aac gtg        3429
Gln Asp  Ser Ile Thr Val Ser  Ala Asp Gly Glu Arg  Phe Asn Val            
    1130                 1135                 1140                        

cgt aaa  cag ctg aat aac gca  aac gtc tat cgt gag  ggt gta gct        3474
Arg Lys  Gln Leu Asn Asn Ala  Asn Val Tyr Arg Glu  Gly Val Ala            
    1145                 1150                 1155                        

acc cag  acc acc gcg tac ggt  aag cgt acc gaa aac  gtt cag tat        3519
Thr Gln  Thr Thr Ala Tyr Gly  Lys Arg Thr Glu Asn  Val Gln Tyr            
    1160                 1165                 1170                        

cgt cac  gtg gaa ctg gca cgt  gtg ggt cag ctg gta  gag gtg gat        3564
Arg His  Val Glu Leu Ala Arg  Val Gly Gln Leu Val  Glu Val Asp            
    1175                 1180                 1185                        

acg ctg  gaa cac gtg cag cac  atc atc ggt ggc gcc  ggt aac gat        3609
Thr Leu  Glu His Val Gln His  Ile Ile Gly Gly Ala  Gly Asn Asp            
    1190                 1195                 1200                        

tcc att  act ggt aac gct cac  gac aac ttc ctg gca  ggt ggt tct        3654
Ser Ile  Thr Gly Asn Ala His  Asp Asn Phe Leu Ala  Gly Gly Ser            
    1205                 1210                 1215                        

ggt gat  gat cgt ctg gac ggt  ggt gcg ggt aac gat  acg ctg gta        3699
Gly Asp  Asp Arg Leu Asp Gly  Gly Ala Gly Asn Asp  Thr Leu Val            
    1220                 1225                 1230                        

ggc ggc  gaa ggt cag aac acc  gta att ggt ggt gcc  ggt gac gac        3744
Gly Gly  Glu Gly Gln Asn Thr  Val Ile Gly Gly Ala  Gly Asp Asp            
    1235                 1240                 1245                        

gtt ttc  ctg cag gat ctg ggc  gtt tgg agc aac cag  ctg gat ggc        3789
Val Phe  Leu Gln Asp Leu Gly  Val Trp Ser Asn Gln  Leu Asp Gly            
    1250                 1255                 1260                        

ggt gcc  ggt gtt gac acg gtt  aag tat aac gtt cac  cag ccg tct        3834
Gly Ala  Gly Val Asp Thr Val  Lys Tyr Asn Val His  Gln Pro Ser            
    1265                 1270                 1275                        

gaa gag  cgc ctg gaa cgt atg  ggt gac act ggt att  cat gcc gat        3879
Glu Glu  Arg Leu Glu Arg Met  Gly Asp Thr Gly Ile  His Ala Asp            
    1280                 1285                 1290                        

ctg cag  aaa ggc act gtt gaa  aaa tgg cct gcg ctg  aac ctg ttc        3924
Leu Gln  Lys Gly Thr Val Glu  Lys Trp Pro Ala Leu  Asn Leu Phe            
    1295                 1300                 1305                        

tct gtg  gac cat gtt aag aac  att gaa aac ctg cat  ggc tct cgc        3969
Ser Val  Asp His Val Lys Asn  Ile Glu Asn Leu His  Gly Ser Arg            
    1310                 1315                 1320                        

ctg aac  gac cgt atc gct ggt  gac gac cag gat aac  gaa ctg tgg        4014
Leu Asn  Asp Arg Ile Ala Gly  Asp Asp Gln Asp Asn  Glu Leu Trp            
    1325                 1330                 1335                        

ggt cat  gac ggc aat gat acc  att cgc ggt cgt ggc  ggc gac gat        4059
Gly His  Asp Gly Asn Asp Thr  Ile Arg Gly Arg Gly  Gly Asp Asp            
    1340                 1345                 1350                        

att ctg  cgt ggc ggt ctg ggc  ctg gat acc ctg tat  ggt gaa gat        4104
Ile Leu  Arg Gly Gly Leu Gly  Leu Asp Thr Leu Tyr  Gly Glu Asp            
    1355                 1360                 1365                        

ggt aac  gat att ttc ctg caa  gac gat gaa acg gta  tct gat gac        4149
Gly Asn  Asp Ile Phe Leu Gln  Asp Asp Glu Thr Val  Ser Asp Asp            
    1370                 1375                 1380                        

atc gac  ggt ggt gca ggc ctg  gac acc gta gat tac  agc gct atg        4194
Ile Asp  Gly Gly Ala Gly Leu  Asp Thr Val Asp Tyr  Ser Ala Met            
    1385                 1390                 1395                        

atc cat  ccg ggt cgt atc gta  gct ccg cac gag tac  ggc ttc ggt        4239
Ile His  Pro Gly Arg Ile Val  Ala Pro His Glu Tyr  Gly Phe Gly            
    1400                 1405                 1410                        

atc gag  gcg gac ctg tct cgt  gaa tgg gtt cgt aaa  gcg tcc gcg        4284
Ile Glu  Ala Asp Leu Ser Arg  Glu Trp Val Arg Lys  Ala Ser Ala            
    1415                 1420                 1425                        

ctg ggt  gtg gac tac tac gat  aac gtt cgt aac gtg  gaa aac gtg        4329
Leu Gly  Val Asp Tyr Tyr Asp  Asn Val Arg Asn Val  Glu Asn Val            
    1430                 1435                 1440                        

atc ggt  acc tcc atg aaa gac  gtg ctg att ggc gac  gca cag gcc        4374
Ile Gly  Thr Ser Met Lys Asp  Val Leu Ile Gly Asp  Ala Gln Ala            
    1445                 1450                 1455                        

aac act  ctg atg ggc cag ggc  ggt gat gac acg gtt  cgc ggc ggc        4419
Asn Thr  Leu Met Gly Gln Gly  Gly Asp Asp Thr Val  Arg Gly Gly            
    1460                 1465                 1470                        

gac ggt  gat gac ctg ctg ttc  ggt ggt gac ggc aac  gac atg ctg        4464
Asp Gly  Asp Asp Leu Leu Phe  Gly Gly Asp Gly Asn  Asp Met Leu            
    1475                 1480                 1485                        

tac ggc  gac gcg ggc aac gac  acc ctg tac ggc ggt  ctg ggt gac        4509
Tyr Gly  Asp Ala Gly Asn Asp  Thr Leu Tyr Gly Gly  Leu Gly Asp            
    1490                 1495                 1500                        

gac act  ctg gaa ggt ggt gca  ggt aac gac tgg ttc  ggc caa acc        4554
Asp Thr  Leu Glu Gly Gly Ala  Gly Asn Asp Trp Phe  Gly Gln Thr            
    1505                 1510                 1515                        

cag gca  cgc gaa cac gac gtg  ctg cgt ggt ggc gac  ggc gta gac        4599
Gln Ala  Arg Glu His Asp Val  Leu Arg Gly Gly Asp  Gly Val Asp            
    1520                 1525                 1530                        

acc gtg  gat tac tcc caa act  ggc gct cac gcg ggt  atc gcg gcc        4644
Thr Val  Asp Tyr Ser Gln Thr  Gly Ala His Ala Gly  Ile Ala Ala            
    1535                 1540                 1545                        

ggt cgt  atc ggt ctg ggc att  ctg gcc gat ctg ggt  gcc ggc cgt        4689
Gly Arg  Ile Gly Leu Gly Ile  Leu Ala Asp Leu Gly  Ala Gly Arg            
    1550                 1555                 1560                        

gtc gac  aaa ctg ggt gag gct  ggc tct agc gcc tat  gat act gtt        4734
Val Asp  Lys Leu Gly Glu Ala  Gly Ser Ser Ala Tyr  Asp Thr Val            
    1565                 1570                 1575                        

tcc ggc  atc gaa aac gtg gta  ggc act gaa ctg gca  gat cgt atc        4779
Ser Gly  Ile Glu Asn Val Val  Gly Thr Glu Leu Ala  Asp Arg Ile            
    1580                 1585                 1590                        

acg ggt  gac gcg caa gcg aac  gtt ctg cgt ggt gct  ggc ggt gca        4824
Thr Gly  Asp Ala Gln Ala Asn  Val Leu Arg Gly Ala  Gly Gly Ala            
    1595                 1600                 1605                        

gac gtg  ctg gcg ggt ggt gaa  ggc gac gac gta ctg  ctg ggc ggt        4869
Asp Val  Leu Ala Gly Gly Glu  Gly Asp Asp Val Leu  Leu Gly Gly            
    1610                 1615                 1620                        

gac ggt  gac gat cag ctg agc  ggt gat gcg ggt cgt  gac cgt ctg        4914
Asp Gly  Asp Asp Gln Leu Ser  Gly Asp Ala Gly Arg  Asp Arg Leu            
    1625                 1630                 1635                        

tac ggt  gaa gca ggt gac gat  tgg ttc ttc cag gac  gct gct aac        4959
Tyr Gly  Glu Ala Gly Asp Asp  Trp Phe Phe Gln Asp  Ala Ala Asn            
    1640                 1645                 1650                        

gct ggc  aac ctg ctg gac ggc  ggc gat ggc cgt gac  act gtt gac        5004
Ala Gly  Asn Leu Leu Asp Gly  Gly Asp Gly Arg Asp  Thr Val Asp            
    1655                 1660                 1665                        

ttc agc  ggt ccg ggt cgc ggt  ctg gac gca ggc gcg  aaa ggc gtt        5049
Phe Ser  Gly Pro Gly Arg Gly  Leu Asp Ala Gly Ala  Lys Gly Val            
    1670                 1675                 1680                        

ttc ctg  agc ctg ggt aag ggt  ttc gca tct ctg atg  gac gaa cca        5094
Phe Leu  Ser Leu Gly Lys Gly  Phe Ala Ser Leu Met  Asp Glu Pro            
    1685                 1690                 1695                        

gaa acc  agc aat gtc ctg cgt  aac atc gaa aac gct  gtc ggt tcc        5139
Glu Thr  Ser Asn Val Leu Arg  Asn Ile Glu Asn Ala  Val Gly Ser            
    1700                 1705                 1710                        

gca cgc  gat gat gtt ctg att  ggc gat gct ggt gcc  aat gtt ctg        5184
Ala Arg  Asp Asp Val Leu Ile  Gly Asp Ala Gly Ala  Asn Val Leu            
    1715                 1720                 1725                        

aac ggt  ctg gcg ggt aat gat  gta ctg tct ggt ggc  gct ggt gat        5229
Asn Gly  Leu Ala Gly Asn Asp  Val Leu Ser Gly Gly  Ala Gly Asp            
    1730                 1735                 1740                        

gat gtc  ctg ctg ggt gat gag  ggc agc gat ctg ctg  tcc ggc gat        5274
Asp Val  Leu Leu Gly Asp Glu  Gly Ser Asp Leu Leu  Ser Gly Asp            
    1745                 1750                 1755                        

gcc ggc  aac gac gat ctg ttc  ggt ggc caa ggt gat  gat act tac        5319
Ala Gly  Asn Asp Asp Leu Phe  Gly Gly Gln Gly Asp  Asp Thr Tyr            
    1760                 1765                 1770                        

ctg ttc  ggc gtt ggc tat ggt  cat gac acc atc tat  gag tct ggt        5364
Leu Phe  Gly Val Gly Tyr Gly  His Asp Thr Ile Tyr  Glu Ser Gly            
    1775                 1780                 1785                        

ggc ggc  cac gat acg att cgt  att aat gca ggt gct  gac caa ctg        5409
Gly Gly  His Asp Thr Ile Arg  Ile Asn Ala Gly Ala  Asp Gln Leu            
    1790                 1795                 1800                        

tgg ttt  gca cgt cag ggt aac  gat ctg gaa att cgc  atc ctg ggt        5454
Trp Phe  Ala Arg Gln Gly Asn  Asp Leu Glu Ile Arg  Ile Leu Gly            
    1805                 1810                 1815                        

act gat  gac gct ctg acc gta  cac gac tgg tac cgc  gat gcg gat        5499
Thr Asp  Asp Ala Leu Thr Val  His Asp Trp Tyr Arg  Asp Ala Asp            
    1820                 1825                 1830                        

cac cgc  gta gaa atc atc cat  gcg gct aac caa gct  gta gac cag        5544
His Arg  Val Glu Ile Ile His  Ala Ala Asn Gln Ala  Val Asp Gln            
    1835                 1840                 1845                        

gct ggt  att gaa aaa ctg gta  gaa gcg atg gca cag  tat ccg gac        5589
Ala Gly  Ile Glu Lys Leu Val  Glu Ala Met Ala Gln  Tyr Pro Asp            
    1850                 1855                 1860                        

cca ggt  gcg gct gct gca gca  cct cca gcg gct cgt  gtg ccg gat        5634
Pro Gly  Ala Ala Ala Ala Ala  Pro Pro Ala Ala Arg  Val Pro Asp            
    1865                 1870                 1875                        

acc ctg  atg cag agc ctg gcc  gtc aat tgg cgt taa                     5670
Thr Leu  Met Gln Ser Leu Ala  Val Asn Trp Arg                             
    1880                 1885                                             


<210>  58
<211>  1889
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58

Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu 
1               5                   10                  15      


Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys 
            20                  25                  30          


Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr 
        35                  40                  45              


Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala 
    50                  55                  60                  


Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro 
65                  70                  75                  80  


Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala 
                85                  90                  95      


Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp 
            100                 105                 110         


Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu 
        115                 120                 125             


Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr 
    130                 135                 140                 


Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala 
145                 150                 155                 160 


Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val 
                165                 170                 175     


Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe 
            180                 185                 190         


Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser 
        195                 200                 205             


Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg 
    210                 215                 220                 


Ala Ala Ser Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val 
225                 230                 235                 240 


Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser 
                245                 250                 255     


Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu 
            260                 265                 270         


Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro Ala Ser Gly Val Asn 
        275                 280                 285             


His Gln His Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met 
    290                 295                 300                 


Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu 
305                 310                 315                 320 


Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr 
                325                 330                 335     


Leu Ser Phe Val Cys Pro Trp Cys Ala Ser Gln Gln Gly Val Ser His 
            340                 345                 350         


Ala Gln Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu 
        355                 360                 365             


Cys Val Cys Cys Lys Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser 
    370                 375                 380                 


Ser Ala Glu Asp Leu Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu 
385                 390                 395                 400 


Ser Phe Val Cys Pro Trp Cys Ala Thr Asn Gln Met His Gly Asp Thr 
                405                 410                 415     


Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp 
            420                 425                 430         


Leu Tyr Cys Tyr Glu Gln Leu Asn Met His Gly Pro Lys Ala Thr Leu 
        435                 440                 445             


Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu Ile Pro Val Asp 
    450                 455                 460                 


Leu Leu Cys His Glu Gln Leu Met His Gly Pro Arg Glu Thr Leu Gln 
465                 470                 475                 480 


Glu Ile Val Leu His Leu Glu Pro Gln Asn Glu Leu Asp Pro Val Asp 
                485                 490                 495     


Leu Leu Cys Tyr Glu Gln Leu Glu Ser Gln Met Leu Thr Arg Gly Gln 
            500                 505                 510         


Leu Lys Glu Tyr Ile Gly Gln Gln Arg Gly Glu Gly Tyr Val Phe Tyr 
        515                 520                 525             


Glu Asn Arg Ala Tyr Gly Val Ala Gly Lys Ser Leu Phe Asp Asp Gly 
    530                 535                 540                 


Leu Gly Ala Ala Pro Gly Val Pro Ser Gly Arg Ser Lys Phe Ser Pro 
545                 550                 555                 560 


Asp Val Leu Glu Thr Val Pro Ala Ser Pro Gly Leu Arg Arg Pro Ser 
                565                 570                 575     


Leu Gly Ala Val Glu Arg Gln Asp Ser Gly Tyr Asp Ser Leu Asp Gly 
            580                 585                 590         


Val Gly Ser Arg Ser Phe Ser Leu Gly Glu Val Ser Asp Met Ala Ala 
        595                 600                 605             


Val Glu Ala Ala Glu Leu Glu Met Thr Arg Gln Val Leu His Ala Gly 
    610                 615                 620                 


Ala Arg Gln Asp Asp Ala Glu Pro Gly Val Ser Gly Ala Ser Ala His 
625                 630                 635                 640 


Trp Gly Gln Arg Ala Leu Gln Gly Ala Gln Ala Val Ala Ala Ala Gln 
                645                 650                 655     


Arg Leu Val His Ala Ile Ala Leu Met Thr Gln Phe Gly Arg Ala Gly 
            660                 665                 670         


Ser Thr Asn Thr Pro Gln Glu Ala Ala Ser Leu Ser Ala Ala Val Phe 
        675                 680                 685             


Gly Leu Gly Glu Ala Ser Ser Ala Val Ala Glu Thr Val Ser Gly Phe 
    690                 695                 700                 


Phe Arg Gly Ser Ser Arg Trp Ala Gly Gly Phe Gly Val Ala Gly Gly 
705                 710                 715                 720 


Ala Met Ala Leu Gly Gly Gly Ile Ala Ala Ala Val Gly Ala Gly Met 
                725                 730                 735     


Ser Leu Thr Asp Asp Ala Pro Ala Gly Gln Lys Ala Ala Ala Gly Ala 
            740                 745                 750         


Glu Ile Ala Leu Gln Leu Thr Gly Gly Thr Val Glu Leu Ala Ser Ser 
        755                 760                 765             


Ile Ala Leu Ala Leu Ala Ala Ala Arg Gly Val Thr Ser Gly Leu Gln 
    770                 775                 780                 


Val Ala Gly Ala Ser Ala Gly Ala Ala Ala Gly Ala Leu Ala Ala Ala 
785                 790                 795                 800 


Leu Ser Pro Met Glu Ile Tyr Gly Leu Val Gln Gln Ser His Tyr Ala 
                805                 810                 815     


Asp Gln Leu Asp Lys Leu Ala Gln Glu Ser Ser Ala Tyr Gly Tyr Glu 
            820                 825                 830         


Gly Asp Ala Leu Leu Ala Gln Leu Tyr Arg Asp Lys Thr Ala Ala Glu 
        835                 840                 845             


Gly Ala Val Ala Gly Val Ser Ala Val Leu Ser Thr Val Gly Ala Ala 
    850                 855                 860                 


Val Ser Ile Ala Ala Ala Ala Ser Val Val Gly Ala Pro Val Ala Val 
865                 870                 875                 880 


Val Thr Ser Leu Leu Thr Gly Ala Leu Asn Gly Ile Leu Arg Gly Val 
                885                 890                 895     


Gln Gln Pro Ile Ile Glu Lys Leu Ala Asn Asp Tyr Ala Arg Lys Ile 
            900                 905                 910         


Asp Glu Leu Gly Gly Pro Gln Ala Tyr Phe Glu Lys Asn Leu Gln Ala 
        915                 920                 925             


Arg His Glu Gln Leu Ala Asn Ser Asp Gly Leu Arg Lys Met Leu Ala 
    930                 935                 940                 


Asp Leu Gln Ala Gly Trp Asn Ala Ser Ser Val Ile Gly Val Gln Thr 
945                 950                 955                 960 


Thr Glu Ile Ser Lys Ser Ala Leu Glu Leu Ala Ala Ile Thr Gly Asn 
                965                 970                 975     


Ala Asp Asn Leu Lys Ser Val Asp Val Phe Val Asp Arg Phe Val Gln 
            980                 985                 990         


Gly Glu Arg Val Ala Gly Gln Pro  Val Val Leu Asp Val  Ala Ala Gly 
        995                 1000                 1005             


Gly Ile  Asp Ile Ala Ser Arg  Lys Gly Glu Arg Pro  Ala Leu Thr 
    1010                 1015                 1020             


Phe Ile  Thr Pro Leu Ala Ala  Pro Gly Glu Glu Gln  Arg Arg Arg 
    1025                 1030                 1035             


Thr Lys  Thr Gly Lys Ser Glu  Phe Thr Thr Phe Val  Glu Ile Val 
    1040                 1045                 1050             


Gly Lys  Gln Asp Arg Trp Arg  Ile Arg Asp Gly Ala  Ala Asp Thr 
    1055                 1060                 1065             


Thr Ile  Asp Leu Ala Lys Val  Val Ser Gln Leu Val  Asp Ala Asn 
    1070                 1075                 1080             


Gly Val  Leu Lys His Ser Ile  Lys Leu Asp Val Ile  Gly Gly Asp 
    1085                 1090                 1095             


Gly Asp  Asp Val Val Leu Ala  Asn Ala Ser Arg Ile  His Tyr Asp 
    1100                 1105                 1110             


Gly Gly  Ala Gly Thr Asn Thr  Val Ser Tyr Ala Ala  Leu Gly Arg 
    1115                 1120                 1125             


Gln Asp  Ser Ile Thr Val Ser  Ala Asp Gly Glu Arg  Phe Asn Val 
    1130                 1135                 1140             


Arg Lys  Gln Leu Asn Asn Ala  Asn Val Tyr Arg Glu  Gly Val Ala 
    1145                 1150                 1155             


Thr Gln  Thr Thr Ala Tyr Gly  Lys Arg Thr Glu Asn  Val Gln Tyr 
    1160                 1165                 1170             


Arg His  Val Glu Leu Ala Arg  Val Gly Gln Leu Val  Glu Val Asp 
    1175                 1180                 1185             


Thr Leu  Glu His Val Gln His  Ile Ile Gly Gly Ala  Gly Asn Asp 
    1190                 1195                 1200             


Ser Ile  Thr Gly Asn Ala His  Asp Asn Phe Leu Ala  Gly Gly Ser 
    1205                 1210                 1215             


Gly Asp  Asp Arg Leu Asp Gly  Gly Ala Gly Asn Asp  Thr Leu Val 
    1220                 1225                 1230             


Gly Gly  Glu Gly Gln Asn Thr  Val Ile Gly Gly Ala  Gly Asp Asp 
    1235                 1240                 1245             


Val Phe  Leu Gln Asp Leu Gly  Val Trp Ser Asn Gln  Leu Asp Gly 
    1250                 1255                 1260             


Gly Ala  Gly Val Asp Thr Val  Lys Tyr Asn Val His  Gln Pro Ser 
    1265                 1270                 1275             


Glu Glu  Arg Leu Glu Arg Met  Gly Asp Thr Gly Ile  His Ala Asp 
    1280                 1285                 1290             


Leu Gln  Lys Gly Thr Val Glu  Lys Trp Pro Ala Leu  Asn Leu Phe 
    1295                 1300                 1305             


Ser Val  Asp His Val Lys Asn  Ile Glu Asn Leu His  Gly Ser Arg 
    1310                 1315                 1320             


Leu Asn  Asp Arg Ile Ala Gly  Asp Asp Gln Asp Asn  Glu Leu Trp 
    1325                 1330                 1335             


Gly His  Asp Gly Asn Asp Thr  Ile Arg Gly Arg Gly  Gly Asp Asp 
    1340                 1345                 1350             


Ile Leu  Arg Gly Gly Leu Gly  Leu Asp Thr Leu Tyr  Gly Glu Asp 
    1355                 1360                 1365             


Gly Asn  Asp Ile Phe Leu Gln  Asp Asp Glu Thr Val  Ser Asp Asp 
    1370                 1375                 1380             


Ile Asp  Gly Gly Ala Gly Leu  Asp Thr Val Asp Tyr  Ser Ala Met 
    1385                 1390                 1395             


Ile His  Pro Gly Arg Ile Val  Ala Pro His Glu Tyr  Gly Phe Gly 
    1400                 1405                 1410             


Ile Glu  Ala Asp Leu Ser Arg  Glu Trp Val Arg Lys  Ala Ser Ala 
    1415                 1420                 1425             


Leu Gly  Val Asp Tyr Tyr Asp  Asn Val Arg Asn Val  Glu Asn Val 
    1430                 1435                 1440             


Ile Gly  Thr Ser Met Lys Asp  Val Leu Ile Gly Asp  Ala Gln Ala 
    1445                 1450                 1455             


Asn Thr  Leu Met Gly Gln Gly  Gly Asp Asp Thr Val  Arg Gly Gly 
    1460                 1465                 1470             


Asp Gly  Asp Asp Leu Leu Phe  Gly Gly Asp Gly Asn  Asp Met Leu 
    1475                 1480                 1485             


Tyr Gly  Asp Ala Gly Asn Asp  Thr Leu Tyr Gly Gly  Leu Gly Asp 
    1490                 1495                 1500             


Asp Thr  Leu Glu Gly Gly Ala  Gly Asn Asp Trp Phe  Gly Gln Thr 
    1505                 1510                 1515             


Gln Ala  Arg Glu His Asp Val  Leu Arg Gly Gly Asp  Gly Val Asp 
    1520                 1525                 1530             


Thr Val  Asp Tyr Ser Gln Thr  Gly Ala His Ala Gly  Ile Ala Ala 
    1535                 1540                 1545             


Gly Arg  Ile Gly Leu Gly Ile  Leu Ala Asp Leu Gly  Ala Gly Arg 
    1550                 1555                 1560             


Val Asp  Lys Leu Gly Glu Ala  Gly Ser Ser Ala Tyr  Asp Thr Val 
    1565                 1570                 1575             


Ser Gly  Ile Glu Asn Val Val  Gly Thr Glu Leu Ala  Asp Arg Ile 
    1580                 1585                 1590             


Thr Gly  Asp Ala Gln Ala Asn  Val Leu Arg Gly Ala  Gly Gly Ala 
    1595                 1600                 1605             


Asp Val  Leu Ala Gly Gly Glu  Gly Asp Asp Val Leu  Leu Gly Gly 
    1610                 1615                 1620             


Asp Gly  Asp Asp Gln Leu Ser  Gly Asp Ala Gly Arg  Asp Arg Leu 
    1625                 1630                 1635             


Tyr Gly  Glu Ala Gly Asp Asp  Trp Phe Phe Gln Asp  Ala Ala Asn 
    1640                 1645                 1650             


Ala Gly  Asn Leu Leu Asp Gly  Gly Asp Gly Arg Asp  Thr Val Asp 
    1655                 1660                 1665             


Phe Ser  Gly Pro Gly Arg Gly  Leu Asp Ala Gly Ala  Lys Gly Val 
    1670                 1675                 1680             


Phe Leu  Ser Leu Gly Lys Gly  Phe Ala Ser Leu Met  Asp Glu Pro 
    1685                 1690                 1695             


Glu Thr  Ser Asn Val Leu Arg  Asn Ile Glu Asn Ala  Val Gly Ser 
    1700                 1705                 1710             


Ala Arg  Asp Asp Val Leu Ile  Gly Asp Ala Gly Ala  Asn Val Leu 
    1715                 1720                 1725             


Asn Gly  Leu Ala Gly Asn Asp  Val Leu Ser Gly Gly  Ala Gly Asp 
    1730                 1735                 1740             


Asp Val  Leu Leu Gly Asp Glu  Gly Ser Asp Leu Leu  Ser Gly Asp 
    1745                 1750                 1755             


Ala Gly  Asn Asp Asp Leu Phe  Gly Gly Gln Gly Asp  Asp Thr Tyr 
    1760                 1765                 1770             


Leu Phe  Gly Val Gly Tyr Gly  His Asp Thr Ile Tyr  Glu Ser Gly 
    1775                 1780                 1785             


Gly Gly  His Asp Thr Ile Arg  Ile Asn Ala Gly Ala  Asp Gln Leu 
    1790                 1795                 1800             


Trp Phe  Ala Arg Gln Gly Asn  Asp Leu Glu Ile Arg  Ile Leu Gly 
    1805                 1810                 1815             


Thr Asp  Asp Ala Leu Thr Val  His Asp Trp Tyr Arg  Asp Ala Asp 
    1820                 1825                 1830             


His Arg  Val Glu Ile Ile His  Ala Ala Asn Gln Ala  Val Asp Gln 
    1835                 1840                 1845             


Ala Gly  Ile Glu Lys Leu Val  Glu Ala Met Ala Gln  Tyr Pro Asp 
    1850                 1855                 1860             


Pro Gly  Ala Ala Ala Ala Ala  Pro Pro Ala Ala Arg  Val Pro Asp 
    1865                 1870                 1875             


Thr Leu  Met Gln Ser Leu Ala  Val Asn Trp Arg 
    1880                 1885                 


<210>  59
<211>  12000
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid comprising SEQ ID NO:57

<400>  59
atcgagatct gtatggctgt gcaggtcgta aatcactgca taattcgtgt cgctcaaggc       60

gcactcccgt tctggataat gttttttgcg ccgacatcat aacggttctg gcaaatattc      120

tgaaatgagc tgttgacaat taatcatcgg ctcgtataat gtgtggaatt gtgagcggat      180

aacaattata attttgttta actttaagaa ggagatatac atatgcagca gtcccatcag      240

gccggttacg caaacgcagc cgatcgtgaa tctggtatcc cggcagcggt tctggatggt      300

attaaggcag ttgccaaaga gaagaacgct accctgatgt tccgtctggt caacccacac      360

tctacttccc tgatcgcgga aggtgtggcg accaaaggcc tgggtgtgca cgccaaaagc      420

agcgactggg gtctgcaggc aggttatatt ccggtgaacc cgaatctgtc taaactgttc      480

ggtcgtgccc cggaggtgat cgcacgtgca gacaacgatg tcaactcttc tctggcgcat      540

ggtcacaccg cggttgatct gaccctgtcc aaagaacgcc tggattacct gcgtcaggcg      600

ggcctggtga cgggcatggc cgacggtgtt gtagcgagca accacgcggg ttatgaacaa      660

tttgagtttc gcgttaaaga gacctctgac ggtcgttacg cggtgcagta ccgccgcaaa      720

ggtggcgatg actttgaagc tgtcaaagtg atcggtaacg ctgctggaat tccgctgacc      780

gcggatatcg acatgtttgc catcatgcct cacctgtcca actttcgcga ttccgcacgc      840

agctctgtga cgtctggtga ttccgtcact gactacctgg ctcgtacccg tcgtgcggcc      900

tctggtcagg cggaaccgga tcgcgcgcac tacaacatcg ttactttttg ttgcaaatgt      960

gattccactc tgcgcctgtg tgtgcaatcc acccacgtag acattcgcac tctggaagac     1020

ctgctgatgg gtacccttgg tattgtttgt ccgatttgct cccagaagcc ggcgtctggc     1080

gttaaccacc aacacctgcc ggcgcgtcgc gcagagccgc agcgtcacac catgctgtgc     1140

atgtgctgta aatgtgaggc ccgtatcgag ctggtcgttg agtctagcgc cgacgatctg     1200

cgtgcgtttc agcagctgtt cctgaacacg ctgagcttcg tttgcccgtg gtgtgctagc     1260

cagcagggcg tgtctcacgc tcagctgccg gcacgtcgtg ctgagcctca gcgtcacaaa     1320

atcctgtgcg tgtgctgcaa atgcgatggc cgcatcgaac tgaccgtgga atctagcgca     1380

gaagacctgc gtacgctgca gcaactgttc ctgagcacgc tgtccttcgt atgcccttgg     1440

tgcgcaacta atcagatgca cggtgacacc ccgaccctgc acgaatacat gctggacctg     1500

cagccagaaa ccaccgatct gtactgttac gaacagctga acatgcatgg cccaaaagct     1560

actctgcagg atatcgtcct gcatctggaa ccacagaacg aaatcccggt agatctgctg     1620

tgccatgagc agctgatgca tggtccgcgt gaaaccctgc aggaaatcgt tctgcacctg     1680

gaaccgcaaa acgaactgga cccggttgac ctgctgtgct atgaacagct ggaatcccag     1740

atgctgactc gtggccagct gaaagaatac atcggccaac agcgtggcga aggctacgtt     1800

ttctacgaga atcgtgctta cggcgttgcg ggcaaatccc tgttcgacga tggtctgggc     1860

gctgcaccgg gcgttccgag cggccgttct aaattcagcc cggacgtact ggaaactgtg     1920

ccggcttccc cgggcctgcg ccgtccgtcc ctgggcgcag tcgaacgtca ggactccggc     1980

tacgattccc tggatggcgt tggctcccgc tccttctccc tgggcgaggt ttctgacatg     2040

gctgcggtgg aagcggcaga gctggaaatg acccgtcaag tgctgcacgc gggcgcacgt     2100

caggacgatg ctgagccggg cgtgtccggt gcgtctgcac actggggtca acgtgccctg     2160

cagggtgctc aagctgtcgc ggcagcgcag cgtctggtac atgcgatcgc actgatgacc     2220

cagttcggtc gcgcaggttc taccaacact cctcaggaag cagctagcct gtctgctgct     2280

gttttcggtc tgggcgaagc gtcttctgcg gttgcagaaa ccgtgagcgg tttcttccgt     2340

ggttctagcc gctgggcggg tggttttggt gtagcaggtg gcgctatggc cctgggtggc     2400

ggtatcgcgg ctgctgtcgg cgcaggtatg agcctgaccg acgatgctcc tgcgggccag     2460

aaagccgcag ctggcgctga aatcgcgctg cagctgactg gtggtaccgt tgaactggct     2520

agctctatcg cgctggctct ggcagcggca cgtggcgtga cttctggcct gcaagtcgcc     2580

ggtgcctctg cgggcgctgc tgcgggcgct ctggcagctg cactgtcccc catggaaatc     2640

tacggtctgg tacagcagtc tcactacgca gaccagctgg ataaactggc gcaggagtct     2700

tctgcatacg gttacgaagg cgacgcactg ctggcgcagc tgtatcgtga caaaactgct     2760

gctgaaggtg ctgtggcagg cgtttctgcg gtactgtcta ccgttggcgc tgcggtttct     2820

attgcggctg ccgcatccgt tgtaggtgcg ccggttgctg tagttacctc tctgctgact     2880

ggtgcactga acggtatcct gcgtggtgtt cagcagccta ttatcgaaaa actggcgaat     2940

gattatgccc gtaaaatcga cgaactgggc ggtccgcagg cttattttga aaaaaacctg     3000

caggcgcgcc acgaacagct ggcaaacagc gacggcctgc gcaaaatgct ggcagacctg     3060

caagctggtt ggaacgcgtc ttctgtgatc ggcgtgcaga ccaccgaaat tagcaaatct     3120

gcgctggaac tggctgcaat tactggcaac gcggataacc tgaaaagcgt tgatgttttt     3180

gtcgatcgct tcgttcaggg cgagcgcgtt gctggtcagc cggttgttct ggacgttgcg     3240

gcaggcggca tcgacatcgc tagccgcaag ggcgagcgtc cggctctgac tttcattacc     3300

ccgctggcag ctccgggtga agaacagcgt cgccgtacca agactggtaa aagcgagttc     3360

accaccttcg tggaaatcgt aggtaaacag gaccgctggc gtattcgcga cggtgcggcg     3420

gacaccacca tcgacctggc aaaagttgtt tcccaactgg tagatgctaa cggcgtgctg     3480

aaacattcta ttaaactgga tgtaatcggc ggtgacggcg atgacgttgt actggcgaac     3540

gcgtctcgta tccactatga cggcggcgca ggtaccaaca cggtttccta cgcagcgctg     3600

ggccgccagg attccatcac tgttagcgcc gatggcgaac gtttcaacgt gcgtaaacag     3660

ctgaataacg caaacgtcta tcgtgagggt gtagctaccc agaccaccgc gtacggtaag     3720

cgtaccgaaa acgttcagta tcgtcacgtg gaactggcac gtgtgggtca gctggtagag     3780

gtggatacgc tggaacacgt gcagcacatc atcggtggcg ccggtaacga ttccattact     3840

ggtaacgctc acgacaactt cctggcaggt ggttctggtg atgatcgtct ggacggtggt     3900

gcgggtaacg atacgctggt aggcggcgaa ggtcagaaca ccgtaattgg tggtgccggt     3960

gacgacgttt tcctgcagga tctgggcgtt tggagcaacc agctggatgg cggtgccggt     4020

gttgacacgg ttaagtataa cgttcaccag ccgtctgaag agcgcctgga acgtatgggt     4080

gacactggta ttcatgccga tctgcagaaa ggcactgttg aaaaatggcc tgcgctgaac     4140

ctgttctctg tggaccatgt taagaacatt gaaaacctgc atggctctcg cctgaacgac     4200

cgtatcgctg gtgacgacca ggataacgaa ctgtggggtc atgacggcaa tgataccatt     4260

cgcggtcgtg gcggcgacga tattctgcgt ggcggtctgg gcctggatac cctgtatggt     4320

gaagatggta acgatatttt cctgcaagac gatgaaacgg tatctgatga catcgacggt     4380

ggtgcaggcc tggacaccgt agattacagc gctatgatcc atccgggtcg tatcgtagct     4440

ccgcacgagt acggcttcgg tatcgaggcg gacctgtctc gtgaatgggt tcgtaaagcg     4500

tccgcgctgg gtgtggacta ctacgataac gttcgtaacg tggaaaacgt gatcggtacc     4560

tccatgaaag acgtgctgat tggcgacgca caggccaaca ctctgatggg ccagggcggt     4620

gatgacacgg ttcgcggcgg cgacggtgat gacctgctgt tcggtggtga cggcaacgac     4680

atgctgtacg gcgacgcggg caacgacacc ctgtacggcg gtctgggtga cgacactctg     4740

gaaggtggtg caggtaacga ctggttcggc caaacccagg cacgcgaaca cgacgtgctg     4800

cgtggtggcg acggcgtaga caccgtggat tactcccaaa ctggcgctca cgcgggtatc     4860

gcggccggtc gtatcggtct gggcattctg gccgatctgg gtgccggccg tgtcgacaaa     4920

ctgggtgagg ctggctctag cgcctatgat actgtttccg gcatcgaaaa cgtggtaggc     4980

actgaactgg cagatcgtat cacgggtgac gcgcaagcga acgttctgcg tggtgctggc     5040

ggtgcagacg tgctggcggg tggtgaaggc gacgacgtac tgctgggcgg tgacggtgac     5100

gatcagctga gcggtgatgc gggtcgtgac cgtctgtacg gtgaagcagg tgacgattgg     5160

ttcttccagg acgctgctaa cgctggcaac ctgctggacg gcggcgatgg ccgtgacact     5220

gttgacttca gcggtccggg tcgcggtctg gacgcaggcg cgaaaggcgt tttcctgagc     5280

ctgggtaagg gtttcgcatc tctgatggac gaaccagaaa ccagcaatgt cctgcgtaac     5340

atcgaaaacg ctgtcggttc cgcacgcgat gatgttctga ttggcgatgc tggtgccaat     5400

gttctgaacg gtctggcggg taatgatgta ctgtctggtg gcgctggtga tgatgtcctg     5460

ctgggtgatg agggcagcga tctgctgtcc ggcgatgccg gcaacgacga tctgttcggt     5520

ggccaaggtg atgatactta cctgttcggc gttggctatg gtcatgacac catctatgag     5580

tctggtggcg gccacgatac gattcgtatt aatgcaggtg ctgaccaact gtggtttgca     5640

cgtcagggta acgatctgga aattcgcatc ctgggtactg atgacgctct gaccgtacac     5700

gactggtacc gcgatgcgga tcaccgcgta gaaatcatcc atgcggctaa ccaagctgta     5760

gaccaggctg gtattgaaaa actggtagaa gcgatggcac agtatccgga cccaggtgcg     5820

gctgctgcag cacctccagc ggctcgtgtg ccggataccc tgatgcagag cctggccgtc     5880

aattggcgtt aatggatcca ggcctcttta gaaggagata taccatgctg ccgtctgcac     5940

aggcgccgtc tctgctgaat ccaactgatg acttcgctgc gctgggtaac atcgcgtggc     6000

tgtggatgaa cagcccgatg caccgtgact ggccggttca cctgctggca cgtaacacgc     6060

tggcgccgat ccagctgggt caatacatcc tgctgcgttg taacgacgtg cctgtggcgt     6120

attgctcctg ggcactgatg gatgcggata ccgagctgtc ctacgttatg gccccatcta     6180

gcctgggcgg taacgcttgg aactgcggcg atcgtctgtg gatcattgat tggattgctc     6240

cgtttagccg tgacgacaac cgtgctctgc gtcgcgcgct ggccgaacgt catccggatt     6300

ctgttggccg ttccctgcgc gtacgtcgcg gtggcgacac cgctcgcgtc aaagaatacc     6360

gtggtcgtgc tctggacgca gcggcggccc gcgctcagct ggaccgctac cacgcagaac     6420

tgattgccgg tctgcgtgca tccaatggcg gttatgctcc gcgtggccgt ggcaccgcat     6480

aatctagaat tctttaatta aagatccggc tgctaacaaa gcccgaaagg aagctgagtt     6540

ggctgctgcc accgctgagc aatccaggca tcaaataaaa cgaaaggctc agtcgaaaga     6600

ctgggccttt cgttttatct gttgtttgtc ggtgaacgct ctcctgagta ggacaaatcc     6660

gccgggagcg gatttgaacg ttgcgaagca acggcccgga gggtggcggg caggacgccc     6720

gccataaact gccaggcatc aaattaagca gaaggccatc ctgacggatg gcctttttgc     6780

tagcagcacg ccatagtgac tggcgatgct gtcggaatgg acgatatccc gcaagaggcc     6840

cggcagtacc ggcataacca agcctatgcc tacagcatcc agggtgacgg tgccgaggat     6900

gacgatgagc gcattgttag atttcataca cggtgcctga ctgcgttagc aatttaactg     6960

tgataaacta ccgcattaaa gcttatcgat gataagctgt caaacatgag aattcttaga     7020

aaaactcatc gagcatcaaa tgaaactgca atttattcat atcaggatta tcaataccat     7080

atttttgaaa aagccgtttc tgtaatgaag gagaaaactc accgaggcag ttccatagga     7140

tggcaagatc ctggtatcgg tctgcgattc cgactcgtcc aacatcaata caacctatta     7200

atttcccctc gtcaaaaata aggttatcaa gtgagaaatc accatgagtg acgactgaat     7260

ccggtgagaa tggcaaaagc ttatgcattt ctttccagac ttgttcaaca ggccagccat     7320

tacgctcgtc atcaaaatca ctcgcatcaa ccaaaccgtt attcattcgt gattgcgcct     7380

gagcgagacg aaatacgcga tcgctgttaa aaggacaatt acaaacagga atcgaatgca     7440

accggcgcag gaacactgcc agcgcatcaa caatattttc acctgaatca ggatattctt     7500

ctaatacctg gaatgctgtt ttcccgggga tcgcagtggt gagtaaccat gcatcatcag     7560

gagtacggat aaaatgcttg atggtcggaa gaggcataaa ttccgtcagc cagtttagtc     7620

tgaccatctc atctgtaaca tcattggcaa cgctaccttt gccatgtttc agaaacaact     7680

ctggcgcatc gggcttccca tacaatcgat agattgtcgc acctgattgc ccgacattat     7740

cgcgagccca tttataccca tataaatcag catccatgtt ggaatttaat cgcggcctcg     7800

agcaagacgt ttcccgttga atatggctca taacacccct tgtattactg tttatgtaag     7860

cagacagttt tattgttcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg     7920

tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc     7980

tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag     8040

ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc     8100

cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac     8160

ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc     8220

gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt     8280

tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt     8340

gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc     8400

ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt     8460

tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca     8520

ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt     8580

tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt     8640

attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag     8700

tcagtgagcg aggaagcgga agagcgcctg atgcggtatt ttctccttac gcatctgtgc     8760

ggtatttcac accgcaatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa     8820

gccagtatac actccgctat cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc     8880

aacacccgct gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc     8940

tgtgaccgtc tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc     9000

gaggcagctg cggtaaagct catcagcgtg gtcgtgaagc gattcacaga tgtctgcctg     9060

ttcatccgcg tccagctcgt tgagtttctc cagaagcgtt aatgtctggc ttctgataaa     9120

gcgggccatg ttaagggcgg ttttttcctg tttggtcact gatgcctccg tgtaaggggg     9180

atttctgttc atgggggtaa tgataccgat gaaacgagag aggatgctca cgatacgggt     9240

tactgatgat gaacatgccc ggttactgga acgttgtgag ggtaaacaac tggcggtatg     9300

gatgcggcgg gaccagagaa aaatcactca gggtcaatgc cagcgcttcg ttaatacaga     9360

tgtaggtgtt ccacagggta gccagcagca tcctgcgatg cagatccgga acataatggt     9420

gcagggcgct gacttccgcg tttccagact ttacgaaaca cggaaaccga agaccattca     9480

tgttgttgct caggtcgcag acgttttgca gcagcagtcg cttcacgttc gctcgcgtat     9540

cggtgattca ttctgctaac cagtaaggca accccgccag cctagccggg tcctcaacga     9600

caggagcacg atcatgcgca cccgtggcca ggacccaacg ctgcccgaga tgcgccgcgt     9660

gcggctgctg gagatggcgg acgcgatgga tatgttctgc caagggttgg tttgcgcatt     9720

cacagttctc cgcaagaatt gattggctcc aattcttgga gtggtgaatc cgttagcgag     9780

gtgccgccgg cttccattca ggtcgaggtg gcccggctcc atgcaccgcg acgcaacgcg     9840

gggaggcaga caaggtatag ggcggcgcct acaatccatg ccaacccgtt ccatgtgctc     9900

gccgaggcgg cataaatcgc cgtgacgatc agcggtccaa tgatcgaagt taggctggta     9960

agagccgcga gcgatccttg aagctgtccc tgatggtcgt catctacctg cctggacagc    10020

atggcctgca acgcgggcat cccgatgccg ccggaagcga gaagaatcat aatggggaag    10080

gccatccagc ctcgcgtcgc gaacgccagc aagacgtagc ccagcgcgtc ggccgccatg    10140

ccggcgataa tggcctgctt ctcgccgaaa cgtttggtgg cgggaccagt gacgaaggct    10200

tgagcgaggg cgtgcaagat tccgaatacc gcaagcgaca ggccgatcat cgtcgcgctc    10260

cagcgaaagc ggtcctcgcc gaaaatgacc cagagcgctg ccggcacctg tcctacgagt    10320

tgcatgataa agaagacagt cataagtgcg gcgacgatag tcatgccccg cgcccaccgg    10380

aaggagctga ctgggttgaa ggctctcaag ggcatcggtc gactcatagc tgtttcctgt    10440

gtgaaattgt tatccgctca caattccaca caacatacga gccggaagca taaagtgtaa    10500

agcctggggt gcctaatgag tgagctaact tacattaatt gcgttgcgct cactgcccgc    10560

tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac gcgcggggag    10620

aggcggtttg cgtattgggc gctagcgtgg tttttctttt caccagtgag acgggcaaca    10680

gctgattgcc cttcaccgcc tggccctgag agagttgcag caagcggtcc acgctggttt    10740

gccccagcag gcgaaaatcc tgtttgatgg tggttaacgg cgggatataa catgagctgt    10800

cttcggtatc gtcgtatccc actaccgaga tatccgcacc aacgcgcagc ccggactcgg    10860

taatggcgcg cattgcgccc agcgccatct gatcgttggc aaccagcatc gcagtgggaa    10920

cgatgccctc attcagcatt tgcatggttt gttgaaaacc ggacatggca ctccagtcgc    10980

cttcccgttc cgctatcggc tgaatttgat tgcgagtgag atatttatgc cagccagcca    11040

gacgcagacg cgccgagaca gaacttaatg ggcccgctaa cagcgcgatt tgctggtgac    11100

ccaatgcgac cagatgctcc acgcccagtc gcgtaccgtc ttcatgggag aaaataatac    11160

tgttgatggg tgtctggtca gagacatcaa gaaataacgc cggaacatta gtgcaggcag    11220

cttccacagc aatggcatcc tggtcatcca gcggatagtt aatgatcagc ccactgacgc    11280

gttgcgcgag aagattgtgc accgccgctt tacaggcttc gacgccgctt cgttctacca    11340

tcgacaccac cacgctggca cccagttgat cggcgcgaga tttaatcgcc gcgacaattt    11400

gcgacggcgc gtgcagggcc agactggagg tggcaacgcc aatcagcaac gactgtttgc    11460

ccgccagttg ttgtgccacg cggttgggaa tgtaattcag ctccgccatc gccgcttcca    11520

ctttttcccg cgttttcgca gaaacgtggc tggcctggtt caccacgcgg gaaacggtct    11580

gataagagac accggcatac tctgcgacat cgtataacgt tactggtttc acattcacca    11640

ccctgaattg actctcttcc gggcgctatc atgccatacc gcgaaaggtt ttgcgccatt    11700

cgatggtgtc ggaatttatg cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc    11760

gcatcaggcg ctcttccgct tcctcgctca ctgactcgct gccaccccgt ggcatgcaag    11820

gagatggcgc ccaacagtcc cccggccacg gggcctgcca ccatacccac gccgaaacaa    11880

gcgctcatga gcccgaagtg gcgagcccga tcttccccat cggtgatgtc ggcgatatag    11940

gcgccagcaa ccgcacctgt ggcgccggtg atgccggcca cgatgcgtcc ggcgtagagg    12000


<210>  60
<211>  5340
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide encoding chimeric CyaA delta 203+ antigen HPV16, HVP18
       and HPV45 acidic-deleted


<220>
<221>  CDS
<222>  (1)..(5340)

<400>  60
atg cag cag tcc cat cag gcc ggt tac gca aac gca gcc gat cgt gaa         48
Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu           
1               5                   10                  15                

tct ggt atc ccg gca gcg gtt ctg gat ggt att aag gca gtt gcc aaa         96
Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys           
            20                  25                  30                    

gag aag aac gct acc ctg atg ttc cgt ctg gtc aac cca cac tct act        144
Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr           
        35                  40                  45                        

tcc ctg atc gcg gaa ggt gtg gcg acc aaa ggc ctg ggt gtg cac gcc        192
Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala           
    50                  55                  60                            

aaa agc agc gac tgg ggt ctg cag gca ggt tat att ccg gtg aac ccg        240
Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro           
65                  70                  75                  80            

aat ctg tct aaa ctg ttc ggt cgt gcc ccg gag gtg atc gca cgt gca        288
Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala           
                85                  90                  95                

gac aac gat gtc aac tct tct ctg gcg cat ggt cac acc gcg gtt gat        336
Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp           
            100                 105                 110                   

ctg acc ctg tcc aaa gaa cgc ctg gat tac ctg cgt cag gcg ggc ctg        384
Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu           
        115                 120                 125                       

gtg acg ggc atg gcc gac ggt gtt gta gcg agc aac cac gcg ggt tat        432
Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr           
    130                 135                 140                           

gaa caa ttt gag ttt cgc gtt aaa gag acc tct gac ggt cgt tac gcg        480
Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala           
145                 150                 155                 160           

gtg cag tac cgc cgc aaa ggt ggc gat gac ttt gaa gct gtc aaa gtg        528
Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val           
                165                 170                 175               

atc ggt aac gct gct gga att ggt cag gcg gaa ccg gat cgc gcg cac        576
Ile Gly Asn Ala Ala Gly Ile Gly Gln Ala Glu Pro Asp Arg Ala His           
            180                 185                 190                   

tac aac atc gtt act ttt tgt tgc aaa tgt gat tcc act ctg cgc ctg        624
Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg Leu           
        195                 200                 205                       

tgt gtg caa tcc acc cac gta gac att cgc act ctg gaa gac ctg ctg        672
Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu           
    210                 215                 220                           

atg ggt acc ctt ggt att gtt tgt ccg att tgc tcc cag aag ccg gcg        720
Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro Ala           
225                 230                 235                 240           

tct ggc gtt aac cac caa cac ctg ccg gcg cgt cgc gca gag ccg cag        768
Ser Gly Val Asn His Gln His Leu Pro Ala Arg Arg Ala Glu Pro Gln           
                245                 250                 255               

cgt cac acc atg ctg tgc atg tgc tgt aaa tgt gag gcc cgt atc gag        816
Arg His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile Glu           
            260                 265                 270                   

ctg gtc gtt gag tct agc gcc gac gat ctg cgt gcg ttt cag cag ctg        864
Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln Leu           
        275                 280                 285                       

ttc ctg aac acg ctg agc ttc gtt tgc ccg tgg tgt gct agc cag cag        912
Phe Leu Asn Thr Leu Ser Phe Val Cys Pro Trp Cys Ala Ser Gln Gln           
    290                 295                 300                           

ggc gtg tct cac gct cag ctg ccg gca cgt cgt gct gag cct cag cgt        960
Gly Val Ser His Ala Gln Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg           
305                 310                 315                 320           

cac aaa atc ctg tgc gtg tgc tgc aaa tgc gat ggc cgc atc gaa ctg       1008
His Lys Ile Leu Cys Val Cys Cys Lys Cys Asp Gly Arg Ile Glu Leu           
                325                 330                 335               

acc gtg gaa tct agc gca gaa gac ctg cgt acg ctg cag caa ctg ttc       1056
Thr Val Glu Ser Ser Ala Glu Asp Leu Arg Thr Leu Gln Gln Leu Phe           
            340                 345                 350                   

ctg agc acg ctg tcc ttc gta tgc cct tgg tgc gca act aat cag atg       1104
Leu Ser Thr Leu Ser Phe Val Cys Pro Trp Cys Ala Thr Asn Gln Met           
        355                 360                 365                       

cac ggt gac acc ccg acc ctg cac gaa tac atg ctg gac ctg cag cca       1152
His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro           
    370                 375                 380                           

gaa acc acc gat ctg tac tgt tac gaa cag ctg aac atg cat ggc cca       1200
Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Met His Gly Pro           
385                 390                 395                 400           

aaa gct act ctg cag gat atc gtc ctg cat ctg gaa cca cag aac gaa       1248
Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu           
                405                 410                 415               

atc ccg gta gat ctg ctg tgc cat gag cag ctg atg cat ggt ccg cgt       1296
Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Met His Gly Pro Arg           
            420                 425                 430                   

gaa acc ctg cag gaa atc gtt ctg cac ctg gaa ccg caa aac gaa ctg       1344
Glu Thr Leu Gln Glu Ile Val Leu His Leu Glu Pro Gln Asn Glu Leu           
        435                 440                 445                       

gac ccg gtt gac ctg ctg tgc tat gaa cag ctg ccg ggc ctg cgc cgt       1392
Asp Pro Val Asp Leu Leu Cys Tyr Glu Gln Leu Pro Gly Leu Arg Arg           
    450                 455                 460                           

ccg tcc ctg ggc gca gtc gaa cgt cag gac tcc ggc tac gat tcc ctg       1440
Pro Ser Leu Gly Ala Val Glu Arg Gln Asp Ser Gly Tyr Asp Ser Leu           
465                 470                 475                 480           

gat ggc gtt ggc tcc cgc tcc ttc tcc ctg ggc gag gtt tct gac atg       1488
Asp Gly Val Gly Ser Arg Ser Phe Ser Leu Gly Glu Val Ser Asp Met           
                485                 490                 495               

gct gcg gtg gaa gcg gca gag ctg gaa atg acc cgt caa gtg ctg cac       1536
Ala Ala Val Glu Ala Ala Glu Leu Glu Met Thr Arg Gln Val Leu His           
            500                 505                 510                   

gcg ggc gca cgt cag gac gat gct gag ccg ggc gtg tcc ggt gcg tct       1584
Ala Gly Ala Arg Gln Asp Asp Ala Glu Pro Gly Val Ser Gly Ala Ser           
        515                 520                 525                       

gca cac tgg ggt caa cgt gcc ctg cag ggt gct caa gct gtc gcg gca       1632
Ala His Trp Gly Gln Arg Ala Leu Gln Gly Ala Gln Ala Val Ala Ala           
    530                 535                 540                           

gcg cag cgt ctg gta cat gcg atc gca ctg atg acc cag ttc ggt cgc       1680
Ala Gln Arg Leu Val His Ala Ile Ala Leu Met Thr Gln Phe Gly Arg           
545                 550                 555                 560           

gca ggt tct acc aac act cct cag gaa gca gct agc ctg tct gct gct       1728
Ala Gly Ser Thr Asn Thr Pro Gln Glu Ala Ala Ser Leu Ser Ala Ala           
                565                 570                 575               

gtt ttc ggt ctg ggc gaa gcg tct tct gcg gtt gca gaa acc gtg agc       1776
Val Phe Gly Leu Gly Glu Ala Ser Ser Ala Val Ala Glu Thr Val Ser           
            580                 585                 590                   

ggt ttc ttc cgt ggt tct agc cgc tgg gcg ggt ggt ttt ggt gta gca       1824
Gly Phe Phe Arg Gly Ser Ser Arg Trp Ala Gly Gly Phe Gly Val Ala           
        595                 600                 605                       

ggt ggc gct atg gcc ctg ggt ggc ggt atc gcg gct gct gtc ggc gca       1872
Gly Gly Ala Met Ala Leu Gly Gly Gly Ile Ala Ala Ala Val Gly Ala           
    610                 615                 620                           

ggt atg agc ctg acc gac gat gct cct gcg ggc cag aaa gcc gca gct       1920
Gly Met Ser Leu Thr Asp Asp Ala Pro Ala Gly Gln Lys Ala Ala Ala           
625                 630                 635                 640           

ggc gct gaa atc gcg ctg cag ctg act ggt ggt acc gtt gaa ctg gct       1968
Gly Ala Glu Ile Ala Leu Gln Leu Thr Gly Gly Thr Val Glu Leu Ala           
                645                 650                 655               

agc tct atc gcg ctg gct ctg gca gcg gca cgt ggc gtg act tct ggc       2016
Ser Ser Ile Ala Leu Ala Leu Ala Ala Ala Arg Gly Val Thr Ser Gly           
            660                 665                 670                   

ctg caa gtc gcc ggt gcc tct gcg ggc gct gct gcg ggc gct ctg gca       2064
Leu Gln Val Ala Gly Ala Ser Ala Gly Ala Ala Ala Gly Ala Leu Ala           
        675                 680                 685                       

gct gca ctg tcc ccc atg gaa atc tac ggt ctg gta cag cag tct cac       2112
Ala Ala Leu Ser Pro Met Glu Ile Tyr Gly Leu Val Gln Gln Ser His           
    690                 695                 700                           

tac gca gac cag ctg gat aaa ctg gcg cag gag tct tct gca tac ggt       2160
Tyr Ala Asp Gln Leu Asp Lys Leu Ala Gln Glu Ser Ser Ala Tyr Gly           
705                 710                 715                 720           

tac gaa ggc gac gca ctg ctg gcg cag ctg tat cgt gac aaa act gct       2208
Tyr Glu Gly Asp Ala Leu Leu Ala Gln Leu Tyr Arg Asp Lys Thr Ala           
                725                 730                 735               

gct gaa ggt gct gtg gca ggc gtt tct gcg gta ctg tct acc gtt ggc       2256
Ala Glu Gly Ala Val Ala Gly Val Ser Ala Val Leu Ser Thr Val Gly           
            740                 745                 750                   

gct gcg gtt tct att gcg gct gcc gca tcc gtt gta ggt gcg ccg gtt       2304
Ala Ala Val Ser Ile Ala Ala Ala Ala Ser Val Val Gly Ala Pro Val           
        755                 760                 765                       

gct gta gtt acc tct ctg ctg act ggt gca ctg aac ggt atc ctg cgt       2352
Ala Val Val Thr Ser Leu Leu Thr Gly Ala Leu Asn Gly Ile Leu Arg           
    770                 775                 780                           

ggt gtt cag cag cct att atc gaa aaa ctg gcg aat gat tat gcc cgt       2400
Gly Val Gln Gln Pro Ile Ile Glu Lys Leu Ala Asn Asp Tyr Ala Arg           
785                 790                 795                 800           

aaa atc gac gaa ctg ggc ggt ccg cag gct tat ttt gaa aaa aac ctg       2448
Lys Ile Asp Glu Leu Gly Gly Pro Gln Ala Tyr Phe Glu Lys Asn Leu           
                805                 810                 815               

cag gcg cgc cac gaa cag ctg gca aac agc gac ggc ctg cgc aaa atg       2496
Gln Ala Arg His Glu Gln Leu Ala Asn Ser Asp Gly Leu Arg Lys Met           
            820                 825                 830                   

ctg gca gac ctg caa gct ggt tgg aac gcg tct tct gtg atc ggc gtg       2544
Leu Ala Asp Leu Gln Ala Gly Trp Asn Ala Ser Ser Val Ile Gly Val           
        835                 840                 845                       

cag acc acc gaa att agc aaa tct gcg ctg gaa ctg gct gca att act       2592
Gln Thr Thr Glu Ile Ser Lys Ser Ala Leu Glu Leu Ala Ala Ile Thr           
    850                 855                 860                           

ggc aac gcg gat aac ctg aaa agc gtt gat gtt ttt gtc gat cgc ttc       2640
Gly Asn Ala Asp Asn Leu Lys Ser Val Asp Val Phe Val Asp Arg Phe           
865                 870                 875                 880           

gtt cag ggc gag cgc gtt gct ggt cag ccg gtt gtt ctg gac gtt gcg       2688
Val Gln Gly Glu Arg Val Ala Gly Gln Pro Val Val Leu Asp Val Ala           
                885                 890                 895               

gca ggc ggc atc gac atc gct agc cgc aag ggc gag cgt ccg gct ctg       2736
Ala Gly Gly Ile Asp Ile Ala Ser Arg Lys Gly Glu Arg Pro Ala Leu           
            900                 905                 910                   

act ttc att acc ccg ctg gca gct ccg ggt gaa gaa cag cgt cgc cgt       2784
Thr Phe Ile Thr Pro Leu Ala Ala Pro Gly Glu Glu Gln Arg Arg Arg           
        915                 920                 925                       

acc aag act ggt aaa agc gag ttc acc acc ttc gtg gaa atc gta ggt       2832
Thr Lys Thr Gly Lys Ser Glu Phe Thr Thr Phe Val Glu Ile Val Gly           
    930                 935                 940                           

aaa cag gac cgc tgg cgt att cgc gac ggt gcg gcg gac acc acc atc       2880
Lys Gln Asp Arg Trp Arg Ile Arg Asp Gly Ala Ala Asp Thr Thr Ile           
945                 950                 955                 960           

gac ctg gca aaa gtt gtt tcc caa ctg gta gat gct aac ggc gtg ctg       2928
Asp Leu Ala Lys Val Val Ser Gln Leu Val Asp Ala Asn Gly Val Leu           
                965                 970                 975               

aaa cat tct att aaa ctg gat gta atc ggc ggt gac ggc gat gac gtt       2976
Lys His Ser Ile Lys Leu Asp Val Ile Gly Gly Asp Gly Asp Asp Val           
            980                 985                 990                   

gta ctg gcg aac gcg tct cgt atc  cac tat gac ggc ggc  gca ggt acc     3024
Val Leu Ala Asn Ala Ser Arg Ile  His Tyr Asp Gly Gly  Ala Gly Thr         
        995                 1000                 1005                     

aac acg  gtt tcc tac gca gcg  ctg ggc cgc cag gat  tcc atc act        3069
Asn Thr  Val Ser Tyr Ala Ala  Leu Gly Arg Gln Asp  Ser Ile Thr            
    1010                 1015                 1020                        

gtt agc  gcc gat ggc gaa cgt  ttc aac gtg cgt aaa  cag ctg aat        3114
Val Ser  Ala Asp Gly Glu Arg  Phe Asn Val Arg Lys  Gln Leu Asn            
    1025                 1030                 1035                        

aac gca  aac gtc tat cgt gag  ggt gta gct acc cag  acc acc gcg        3159
Asn Ala  Asn Val Tyr Arg Glu  Gly Val Ala Thr Gln  Thr Thr Ala            
    1040                 1045                 1050                        

tac ggt  aag cgt acc gaa aac  gtt cag tat cgt cac  gtg gaa ctg        3204
Tyr Gly  Lys Arg Thr Glu Asn  Val Gln Tyr Arg His  Val Glu Leu            
    1055                 1060                 1065                        

gca cgt  gtg ggt cag ctg gta  gag gtg gat acg ctg  gaa cac gtg        3249
Ala Arg  Val Gly Gln Leu Val  Glu Val Asp Thr Leu  Glu His Val            
    1070                 1075                 1080                        

cag cac  atc atc ggt ggc gcc  ggt aac gat tcc att  act ggt aac        3294
Gln His  Ile Ile Gly Gly Ala  Gly Asn Asp Ser Ile  Thr Gly Asn            
    1085                 1090                 1095                        

gct cac  gac aac ttc ctg gca  ggt ggt tct ggt gat  gat cgt ctg        3339
Ala His  Asp Asn Phe Leu Ala  Gly Gly Ser Gly Asp  Asp Arg Leu            
    1100                 1105                 1110                        

gac ggt  ggt gcg ggt aac gat  acg ctg gta ggc ggc  gaa ggt cag        3384
Asp Gly  Gly Ala Gly Asn Asp  Thr Leu Val Gly Gly  Glu Gly Gln            
    1115                 1120                 1125                        

aac acc  gta att ggt ggt gcc  ggt gac gac gtt ttc  ctg cag gat        3429
Asn Thr  Val Ile Gly Gly Ala  Gly Asp Asp Val Phe  Leu Gln Asp            
    1130                 1135                 1140                        

ctg ggc  gtt tgg agc aac cag  ctg gat ggc ggt gcc  ggt gtt gac        3474
Leu Gly  Val Trp Ser Asn Gln  Leu Asp Gly Gly Ala  Gly Val Asp            
    1145                 1150                 1155                        

acg gtt  aag tat aac gtt cac  cag ccg tct gaa gag  cgc ctg gaa        3519
Thr Val  Lys Tyr Asn Val His  Gln Pro Ser Glu Glu  Arg Leu Glu            
    1160                 1165                 1170                        

cgt atg  ggt gac act ggt att  cat gcc gat ctg cag  aaa ggc act        3564
Arg Met  Gly Asp Thr Gly Ile  His Ala Asp Leu Gln  Lys Gly Thr            
    1175                 1180                 1185                        

gtt gaa  aaa tgg cct gcg ctg  aac ctg ttc tct gtg  gac cat gtt        3609
Val Glu  Lys Trp Pro Ala Leu  Asn Leu Phe Ser Val  Asp His Val            
    1190                 1195                 1200                        

aag aac  att gaa aac ctg cat  ggc tct cgc ctg aac  gac cgt atc        3654
Lys Asn  Ile Glu Asn Leu His  Gly Ser Arg Leu Asn  Asp Arg Ile            
    1205                 1210                 1215                        

gct ggt  gac gac cag gat aac  gaa ctg tgg ggt cat  gac ggc aat        3699
Ala Gly  Asp Asp Gln Asp Asn  Glu Leu Trp Gly His  Asp Gly Asn            
    1220                 1225                 1230                        

gat acc  att cgc ggt cgt ggc  ggc gac gat att ctg  cgt ggc ggt        3744
Asp Thr  Ile Arg Gly Arg Gly  Gly Asp Asp Ile Leu  Arg Gly Gly            
    1235                 1240                 1245                        

ctg ggc  ctg gat acc ctg tat  ggt gaa gat ggt aac  gat att ttc        3789
Leu Gly  Leu Asp Thr Leu Tyr  Gly Glu Asp Gly Asn  Asp Ile Phe            
    1250                 1255                 1260                        

ctg caa  gac gat gaa acg gta  tct gat gac atc gac  ggt ggt gca        3834
Leu Gln  Asp Asp Glu Thr Val  Ser Asp Asp Ile Asp  Gly Gly Ala            
    1265                 1270                 1275                        

ggc ctg  gac acc gta gat tac  agc gct atg atc cat  ccg ggt cgt        3879
Gly Leu  Asp Thr Val Asp Tyr  Ser Ala Met Ile His  Pro Gly Arg            
    1280                 1285                 1290                        

atc gta  gct ccg cac gag tac  ggc ttc ggt atc gag  gcg gac ctg        3924
Ile Val  Ala Pro His Glu Tyr  Gly Phe Gly Ile Glu  Ala Asp Leu            
    1295                 1300                 1305                        

tct cgt  gaa tgg gtt cgt aaa  gcg tcc gcg ctg ggt  gtg gac tac        3969
Ser Arg  Glu Trp Val Arg Lys  Ala Ser Ala Leu Gly  Val Asp Tyr            
    1310                 1315                 1320                        

tac gat  aac gtt cgt aac gtg  gaa aac gtg atc ggt  acc tcc atg        4014
Tyr Asp  Asn Val Arg Asn Val  Glu Asn Val Ile Gly  Thr Ser Met            
    1325                 1330                 1335                        

aaa gac  gtg ctg att ggc gac  gca cag gcc aac act  ctg atg ggc        4059
Lys Asp  Val Leu Ile Gly Asp  Ala Gln Ala Asn Thr  Leu Met Gly            
    1340                 1345                 1350                        

cag ggc  ggt gat gac acg gtt  cgc ggc ggc gac ggt  gat gac ctg        4104
Gln Gly  Gly Asp Asp Thr Val  Arg Gly Gly Asp Gly  Asp Asp Leu            
    1355                 1360                 1365                        

ctg ttc  ggt ggt gac ggc aac  gac atg ctg tac ggc  gac gcg ggc        4149
Leu Phe  Gly Gly Asp Gly Asn  Asp Met Leu Tyr Gly  Asp Ala Gly            
    1370                 1375                 1380                        

aac gac  acc ctg tac ggc ggt  ctg ggt gac gac act  ctg gaa ggt        4194
Asn Asp  Thr Leu Tyr Gly Gly  Leu Gly Asp Asp Thr  Leu Glu Gly            
    1385                 1390                 1395                        

ggt gca  ggt aac gac tgg ttc  ggc caa acc cag gca  cgc gaa cac        4239
Gly Ala  Gly Asn Asp Trp Phe  Gly Gln Thr Gln Ala  Arg Glu His            
    1400                 1405                 1410                        

gac gtg  ctg cgt ggt ggc gac  ggc gta gac acc gtg  gat tac tcc        4284
Asp Val  Leu Arg Gly Gly Asp  Gly Val Asp Thr Val  Asp Tyr Ser            
    1415                 1420                 1425                        

caa act  ggc gct cac gcg ggt  atc gcg gcc ggt cgt  atc ggt ctg        4329
Gln Thr  Gly Ala His Ala Gly  Ile Ala Ala Gly Arg  Ile Gly Leu            
    1430                 1435                 1440                        

ggc att  ctg gcc gat ctg ggt  gcc ggc cgt gtc gac  aaa ctg ggt        4374
Gly Ile  Leu Ala Asp Leu Gly  Ala Gly Arg Val Asp  Lys Leu Gly            
    1445                 1450                 1455                        

gag gct  ggc tct agc gcc tat  gat act gtt tcc ggc  atc gaa aac        4419
Glu Ala  Gly Ser Ser Ala Tyr  Asp Thr Val Ser Gly  Ile Glu Asn            
    1460                 1465                 1470                        

gtg gta  ggc act gaa ctg gca  gat cgt atc acg ggt  gac gcg caa        4464
Val Val  Gly Thr Glu Leu Ala  Asp Arg Ile Thr Gly  Asp Ala Gln            
    1475                 1480                 1485                        

gcg aac  gtt ctg cgt ggt gct  ggc ggt gca gac gtg  ctg gcg ggt        4509
Ala Asn  Val Leu Arg Gly Ala  Gly Gly Ala Asp Val  Leu Ala Gly            
    1490                 1495                 1500                        

ggt gaa  ggc gac gac gta ctg  ctg ggc ggt gac ggt  gac gat cag        4554
Gly Glu  Gly Asp Asp Val Leu  Leu Gly Gly Asp Gly  Asp Asp Gln            
    1505                 1510                 1515                        

ctg agc  ggt gat gcg ggt cgt  gac cgt ctg tac ggt  gaa gca ggt        4599
Leu Ser  Gly Asp Ala Gly Arg  Asp Arg Leu Tyr Gly  Glu Ala Gly            
    1520                 1525                 1530                        

gac gat  tgg ttc ttc cag gac  gct gct aac gct ggc  aac ctg ctg        4644
Asp Asp  Trp Phe Phe Gln Asp  Ala Ala Asn Ala Gly  Asn Leu Leu            
    1535                 1540                 1545                        

gac ggc  ggc gat ggc cgt gac  act gtt gac ttc agc  ggt ccg ggt        4689
Asp Gly  Gly Asp Gly Arg Asp  Thr Val Asp Phe Ser  Gly Pro Gly            
    1550                 1555                 1560                        

cgc ggt  ctg gac gca ggc gcg  aaa ggc gtt ttc ctg  agc ctg ggt        4734
Arg Gly  Leu Asp Ala Gly Ala  Lys Gly Val Phe Leu  Ser Leu Gly            
    1565                 1570                 1575                        

aag ggt  ttc gca tct ctg atg  gac gaa cca gaa acc  agc aat gtc        4779
Lys Gly  Phe Ala Ser Leu Met  Asp Glu Pro Glu Thr  Ser Asn Val            
    1580                 1585                 1590                        

ctg cgt  aac atc gaa aac gct  gtc ggt tcc gca cgc  gat gat gtt        4824
Leu Arg  Asn Ile Glu Asn Ala  Val Gly Ser Ala Arg  Asp Asp Val            
    1595                 1600                 1605                        

ctg att  ggc gat gct ggt gcc  aat gtt ctg aac ggt  ctg gcg ggt        4869
Leu Ile  Gly Asp Ala Gly Ala  Asn Val Leu Asn Gly  Leu Ala Gly            
    1610                 1615                 1620                        

aat gat  gta ctg tct ggt ggc  gct ggt gat gat gtc  ctg ctg ggt        4914
Asn Asp  Val Leu Ser Gly Gly  Ala Gly Asp Asp Val  Leu Leu Gly            
    1625                 1630                 1635                        

gat gag  ggc agc gat ctg ctg  tcc ggc gat gcc ggc  aac gac gat        4959
Asp Glu  Gly Ser Asp Leu Leu  Ser Gly Asp Ala Gly  Asn Asp Asp            
    1640                 1645                 1650                        

ctg ttc  ggt ggc caa ggt gat  gat act tac ctg ttc  ggc gtt ggc        5004
Leu Phe  Gly Gly Gln Gly Asp  Asp Thr Tyr Leu Phe  Gly Val Gly            
    1655                 1660                 1665                        

tat ggt  cat gac acc atc tat  gag tct ggt ggc ggc  cac gat acg        5049
Tyr Gly  His Asp Thr Ile Tyr  Glu Ser Gly Gly Gly  His Asp Thr            
    1670                 1675                 1680                        

att cgt  att aat gca ggt gct  gac caa ctg tgg ttt  gca cgt cag        5094
Ile Arg  Ile Asn Ala Gly Ala  Asp Gln Leu Trp Phe  Ala Arg Gln            
    1685                 1690                 1695                        

ggt aac  gat ctg gaa att cgc  atc ctg ggt act gat  gac gct ctg        5139
Gly Asn  Asp Leu Glu Ile Arg  Ile Leu Gly Thr Asp  Asp Ala Leu            
    1700                 1705                 1710                        

acc gta  cac gac tgg tac cgc  gat gcg gat cac cgc  gta gaa atc        5184
Thr Val  His Asp Trp Tyr Arg  Asp Ala Asp His Arg  Val Glu Ile            
    1715                 1720                 1725                        

atc cat  gcg gct aac caa gct  gta gac cag gct ggt  att gaa aaa        5229
Ile His  Ala Ala Asn Gln Ala  Val Asp Gln Ala Gly  Ile Glu Lys            
    1730                 1735                 1740                        

ctg gta  gaa gcg atg gca cag  tat ccg gac cca ggt  gcg gct gct        5274
Leu Val  Glu Ala Met Ala Gln  Tyr Pro Asp Pro Gly  Ala Ala Ala            
    1745                 1750                 1755                        

gca gca  cct cca gcg gct cgt  gtg ccg gat acc ctg  atg cag agc        5319
Ala Ala  Pro Pro Ala Ala Arg  Val Pro Asp Thr Leu  Met Gln Ser            
    1760                 1765                 1770                        

ctg gcc  gtc aat tgg cgt taa                                          5340
Leu Ala  Val Asn Trp Arg                                                  
    1775                                                                  


<210>  61
<211>  1779
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  61

Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu 
1               5                   10                  15      


Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys 
            20                  25                  30          


Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr 
        35                  40                  45              


Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala 
    50                  55                  60                  


Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro 
65                  70                  75                  80  


Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala 
                85                  90                  95      


Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp 
            100                 105                 110         


Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu 
        115                 120                 125             


Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr 
    130                 135                 140                 


Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala 
145                 150                 155                 160 


Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val 
                165                 170                 175     


Ile Gly Asn Ala Ala Gly Ile Gly Gln Ala Glu Pro Asp Arg Ala His 
            180                 185                 190         


Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg Leu 
        195                 200                 205             


Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu 
    210                 215                 220                 


Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro Ala 
225                 230                 235                 240 


Ser Gly Val Asn His Gln His Leu Pro Ala Arg Arg Ala Glu Pro Gln 
                245                 250                 255     


Arg His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile Glu 
            260                 265                 270         


Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln Leu 
        275                 280                 285             


Phe Leu Asn Thr Leu Ser Phe Val Cys Pro Trp Cys Ala Ser Gln Gln 
    290                 295                 300                 


Gly Val Ser His Ala Gln Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg 
305                 310                 315                 320 


His Lys Ile Leu Cys Val Cys Cys Lys Cys Asp Gly Arg Ile Glu Leu 
                325                 330                 335     


Thr Val Glu Ser Ser Ala Glu Asp Leu Arg Thr Leu Gln Gln Leu Phe 
            340                 345                 350         


Leu Ser Thr Leu Ser Phe Val Cys Pro Trp Cys Ala Thr Asn Gln Met 
        355                 360                 365             


His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro 
    370                 375                 380                 


Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Met His Gly Pro 
385                 390                 395                 400 


Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu 
                405                 410                 415     


Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Met His Gly Pro Arg 
            420                 425                 430         


Glu Thr Leu Gln Glu Ile Val Leu His Leu Glu Pro Gln Asn Glu Leu 
        435                 440                 445             


Asp Pro Val Asp Leu Leu Cys Tyr Glu Gln Leu Pro Gly Leu Arg Arg 
    450                 455                 460                 


Pro Ser Leu Gly Ala Val Glu Arg Gln Asp Ser Gly Tyr Asp Ser Leu 
465                 470                 475                 480 


Asp Gly Val Gly Ser Arg Ser Phe Ser Leu Gly Glu Val Ser Asp Met 
                485                 490                 495     


Ala Ala Val Glu Ala Ala Glu Leu Glu Met Thr Arg Gln Val Leu His 
            500                 505                 510         


Ala Gly Ala Arg Gln Asp Asp Ala Glu Pro Gly Val Ser Gly Ala Ser 
        515                 520                 525             


Ala His Trp Gly Gln Arg Ala Leu Gln Gly Ala Gln Ala Val Ala Ala 
    530                 535                 540                 


Ala Gln Arg Leu Val His Ala Ile Ala Leu Met Thr Gln Phe Gly Arg 
545                 550                 555                 560 


Ala Gly Ser Thr Asn Thr Pro Gln Glu Ala Ala Ser Leu Ser Ala Ala 
                565                 570                 575     


Val Phe Gly Leu Gly Glu Ala Ser Ser Ala Val Ala Glu Thr Val Ser 
            580                 585                 590         


Gly Phe Phe Arg Gly Ser Ser Arg Trp Ala Gly Gly Phe Gly Val Ala 
        595                 600                 605             


Gly Gly Ala Met Ala Leu Gly Gly Gly Ile Ala Ala Ala Val Gly Ala 
    610                 615                 620                 


Gly Met Ser Leu Thr Asp Asp Ala Pro Ala Gly Gln Lys Ala Ala Ala 
625                 630                 635                 640 


Gly Ala Glu Ile Ala Leu Gln Leu Thr Gly Gly Thr Val Glu Leu Ala 
                645                 650                 655     


Ser Ser Ile Ala Leu Ala Leu Ala Ala Ala Arg Gly Val Thr Ser Gly 
            660                 665                 670         


Leu Gln Val Ala Gly Ala Ser Ala Gly Ala Ala Ala Gly Ala Leu Ala 
        675                 680                 685             


Ala Ala Leu Ser Pro Met Glu Ile Tyr Gly Leu Val Gln Gln Ser His 
    690                 695                 700                 


Tyr Ala Asp Gln Leu Asp Lys Leu Ala Gln Glu Ser Ser Ala Tyr Gly 
705                 710                 715                 720 


Tyr Glu Gly Asp Ala Leu Leu Ala Gln Leu Tyr Arg Asp Lys Thr Ala 
                725                 730                 735     


Ala Glu Gly Ala Val Ala Gly Val Ser Ala Val Leu Ser Thr Val Gly 
            740                 745                 750         


Ala Ala Val Ser Ile Ala Ala Ala Ala Ser Val Val Gly Ala Pro Val 
        755                 760                 765             


Ala Val Val Thr Ser Leu Leu Thr Gly Ala Leu Asn Gly Ile Leu Arg 
    770                 775                 780                 


Gly Val Gln Gln Pro Ile Ile Glu Lys Leu Ala Asn Asp Tyr Ala Arg 
785                 790                 795                 800 


Lys Ile Asp Glu Leu Gly Gly Pro Gln Ala Tyr Phe Glu Lys Asn Leu 
                805                 810                 815     


Gln Ala Arg His Glu Gln Leu Ala Asn Ser Asp Gly Leu Arg Lys Met 
            820                 825                 830         


Leu Ala Asp Leu Gln Ala Gly Trp Asn Ala Ser Ser Val Ile Gly Val 
        835                 840                 845             


Gln Thr Thr Glu Ile Ser Lys Ser Ala Leu Glu Leu Ala Ala Ile Thr 
    850                 855                 860                 


Gly Asn Ala Asp Asn Leu Lys Ser Val Asp Val Phe Val Asp Arg Phe 
865                 870                 875                 880 


Val Gln Gly Glu Arg Val Ala Gly Gln Pro Val Val Leu Asp Val Ala 
                885                 890                 895     


Ala Gly Gly Ile Asp Ile Ala Ser Arg Lys Gly Glu Arg Pro Ala Leu 
            900                 905                 910         


Thr Phe Ile Thr Pro Leu Ala Ala Pro Gly Glu Glu Gln Arg Arg Arg 
        915                 920                 925             


Thr Lys Thr Gly Lys Ser Glu Phe Thr Thr Phe Val Glu Ile Val Gly 
    930                 935                 940                 


Lys Gln Asp Arg Trp Arg Ile Arg Asp Gly Ala Ala Asp Thr Thr Ile 
945                 950                 955                 960 


Asp Leu Ala Lys Val Val Ser Gln Leu Val Asp Ala Asn Gly Val Leu 
                965                 970                 975     


Lys His Ser Ile Lys Leu Asp Val Ile Gly Gly Asp Gly Asp Asp Val 
            980                 985                 990         


Val Leu Ala Asn Ala Ser Arg Ile  His Tyr Asp Gly Gly  Ala Gly Thr 
        995                 1000                 1005             


Asn Thr  Val Ser Tyr Ala Ala  Leu Gly Arg Gln Asp  Ser Ile Thr 
    1010                 1015                 1020             


Val Ser  Ala Asp Gly Glu Arg  Phe Asn Val Arg Lys  Gln Leu Asn 
    1025                 1030                 1035             


Asn Ala  Asn Val Tyr Arg Glu  Gly Val Ala Thr Gln  Thr Thr Ala 
    1040                 1045                 1050             


Tyr Gly  Lys Arg Thr Glu Asn  Val Gln Tyr Arg His  Val Glu Leu 
    1055                 1060                 1065             


Ala Arg  Val Gly Gln Leu Val  Glu Val Asp Thr Leu  Glu His Val 
    1070                 1075                 1080             


Gln His  Ile Ile Gly Gly Ala  Gly Asn Asp Ser Ile  Thr Gly Asn 
    1085                 1090                 1095             


Ala His  Asp Asn Phe Leu Ala  Gly Gly Ser Gly Asp  Asp Arg Leu 
    1100                 1105                 1110             


Asp Gly  Gly Ala Gly Asn Asp  Thr Leu Val Gly Gly  Glu Gly Gln 
    1115                 1120                 1125             


Asn Thr  Val Ile Gly Gly Ala  Gly Asp Asp Val Phe  Leu Gln Asp 
    1130                 1135                 1140             


Leu Gly  Val Trp Ser Asn Gln  Leu Asp Gly Gly Ala  Gly Val Asp 
    1145                 1150                 1155             


Thr Val  Lys Tyr Asn Val His  Gln Pro Ser Glu Glu  Arg Leu Glu 
    1160                 1165                 1170             


Arg Met  Gly Asp Thr Gly Ile  His Ala Asp Leu Gln  Lys Gly Thr 
    1175                 1180                 1185             


Val Glu  Lys Trp Pro Ala Leu  Asn Leu Phe Ser Val  Asp His Val 
    1190                 1195                 1200             


Lys Asn  Ile Glu Asn Leu His  Gly Ser Arg Leu Asn  Asp Arg Ile 
    1205                 1210                 1215             


Ala Gly  Asp Asp Gln Asp Asn  Glu Leu Trp Gly His  Asp Gly Asn 
    1220                 1225                 1230             


Asp Thr  Ile Arg Gly Arg Gly  Gly Asp Asp Ile Leu  Arg Gly Gly 
    1235                 1240                 1245             


Leu Gly  Leu Asp Thr Leu Tyr  Gly Glu Asp Gly Asn  Asp Ile Phe 
    1250                 1255                 1260             


Leu Gln  Asp Asp Glu Thr Val  Ser Asp Asp Ile Asp  Gly Gly Ala 
    1265                 1270                 1275             


Gly Leu  Asp Thr Val Asp Tyr  Ser Ala Met Ile His  Pro Gly Arg 
    1280                 1285                 1290             


Ile Val  Ala Pro His Glu Tyr  Gly Phe Gly Ile Glu  Ala Asp Leu 
    1295                 1300                 1305             


Ser Arg  Glu Trp Val Arg Lys  Ala Ser Ala Leu Gly  Val Asp Tyr 
    1310                 1315                 1320             


Tyr Asp  Asn Val Arg Asn Val  Glu Asn Val Ile Gly  Thr Ser Met 
    1325                 1330                 1335             


Lys Asp  Val Leu Ile Gly Asp  Ala Gln Ala Asn Thr  Leu Met Gly 
    1340                 1345                 1350             


Gln Gly  Gly Asp Asp Thr Val  Arg Gly Gly Asp Gly  Asp Asp Leu 
    1355                 1360                 1365             


Leu Phe  Gly Gly Asp Gly Asn  Asp Met Leu Tyr Gly  Asp Ala Gly 
    1370                 1375                 1380             


Asn Asp  Thr Leu Tyr Gly Gly  Leu Gly Asp Asp Thr  Leu Glu Gly 
    1385                 1390                 1395             


Gly Ala  Gly Asn Asp Trp Phe  Gly Gln Thr Gln Ala  Arg Glu His 
    1400                 1405                 1410             


Asp Val  Leu Arg Gly Gly Asp  Gly Val Asp Thr Val  Asp Tyr Ser 
    1415                 1420                 1425             


Gln Thr  Gly Ala His Ala Gly  Ile Ala Ala Gly Arg  Ile Gly Leu 
    1430                 1435                 1440             


Gly Ile  Leu Ala Asp Leu Gly  Ala Gly Arg Val Asp  Lys Leu Gly 
    1445                 1450                 1455             


Glu Ala  Gly Ser Ser Ala Tyr  Asp Thr Val Ser Gly  Ile Glu Asn 
    1460                 1465                 1470             


Val Val  Gly Thr Glu Leu Ala  Asp Arg Ile Thr Gly  Asp Ala Gln 
    1475                 1480                 1485             


Ala Asn  Val Leu Arg Gly Ala  Gly Gly Ala Asp Val  Leu Ala Gly 
    1490                 1495                 1500             


Gly Glu  Gly Asp Asp Val Leu  Leu Gly Gly Asp Gly  Asp Asp Gln 
    1505                 1510                 1515             


Leu Ser  Gly Asp Ala Gly Arg  Asp Arg Leu Tyr Gly  Glu Ala Gly 
    1520                 1525                 1530             


Asp Asp  Trp Phe Phe Gln Asp  Ala Ala Asn Ala Gly  Asn Leu Leu 
    1535                 1540                 1545             


Asp Gly  Gly Asp Gly Arg Asp  Thr Val Asp Phe Ser  Gly Pro Gly 
    1550                 1555                 1560             


Arg Gly  Leu Asp Ala Gly Ala  Lys Gly Val Phe Leu  Ser Leu Gly 
    1565                 1570                 1575             


Lys Gly  Phe Ala Ser Leu Met  Asp Glu Pro Glu Thr  Ser Asn Val 
    1580                 1585                 1590             


Leu Arg  Asn Ile Glu Asn Ala  Val Gly Ser Ala Arg  Asp Asp Val 
    1595                 1600                 1605             


Leu Ile  Gly Asp Ala Gly Ala  Asn Val Leu Asn Gly  Leu Ala Gly 
    1610                 1615                 1620             


Asn Asp  Val Leu Ser Gly Gly  Ala Gly Asp Asp Val  Leu Leu Gly 
    1625                 1630                 1635             


Asp Glu  Gly Ser Asp Leu Leu  Ser Gly Asp Ala Gly  Asn Asp Asp 
    1640                 1645                 1650             


Leu Phe  Gly Gly Gln Gly Asp  Asp Thr Tyr Leu Phe  Gly Val Gly 
    1655                 1660                 1665             


Tyr Gly  His Asp Thr Ile Tyr  Glu Ser Gly Gly Gly  His Asp Thr 
    1670                 1675                 1680             


Ile Arg  Ile Asn Ala Gly Ala  Asp Gln Leu Trp Phe  Ala Arg Gln 
    1685                 1690                 1695             


Gly Asn  Asp Leu Glu Ile Arg  Ile Leu Gly Thr Asp  Asp Ala Leu 
    1700                 1705                 1710             


Thr Val  His Asp Trp Tyr Arg  Asp Ala Asp His Arg  Val Glu Ile 
    1715                 1720                 1725             


Ile His  Ala Ala Asn Gln Ala  Val Asp Gln Ala Gly  Ile Glu Lys 
    1730                 1735                 1740             


Leu Val  Glu Ala Met Ala Gln  Tyr Pro Asp Pro Gly  Ala Ala Ala 
    1745                 1750                 1755             


Ala Ala  Pro Pro Ala Ala Arg  Val Pro Asp Thr Leu  Met Gln Ser 
    1760                 1765                 1770             


Leu Ala  Val Asn Trp Arg 
    1775                 


<210>  62
<211>  11670
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid comprising SEQ ID NO:60.

<400>  62
atcgagatct gtatggctgt gcaggtcgta aatcactgca taattcgtgt cgctcaaggc       60

gcactcccgt tctggataat gttttttgcg ccgacatcat aacggttctg gcaaatattc      120

tgaaatgagc tgttgacaat taatcatcgg ctcgtataat gtgtggaatt gtgagcggat      180

aacaattata attttgttta actttaagaa ggagatatac atatgcagca gtcccatcag      240

gccggttacg caaacgcagc cgatcgtgaa tctggtatcc cggcagcggt tctggatggt      300

attaaggcag ttgccaaaga gaagaacgct accctgatgt tccgtctggt caacccacac      360

tctacttccc tgatcgcgga aggtgtggcg accaaaggcc tgggtgtgca cgccaaaagc      420

agcgactggg gtctgcaggc aggttatatt ccggtgaacc cgaatctgtc taaactgttc      480

ggtcgtgccc cggaggtgat cgcacgtgca gacaacgatg tcaactcttc tctggcgcat      540

ggtcacaccg cggttgatct gaccctgtcc aaagaacgcc tggattacct gcgtcaggcg      600

ggcctggtga cgggcatggc cgacggtgtt gtagcgagca accacgcggg ttatgaacaa      660

tttgagtttc gcgttaaaga gacctctgac ggtcgttacg cggtgcagta ccgccgcaaa      720

ggtggcgatg actttgaagc tgtcaaagtg atcggtaacg ctgctggaat tggtcaggcg      780

gaaccggatc gcgcgcacta caacatcgtt actttttgtt gcaaatgtga ttccactctg      840

cgcctgtgtg tgcaatccac ccacgtagac attcgcactc tggaagacct gctgatgggt      900

acccttggta ttgtttgtcc gatttgctcc cagaagccgg cgtctggcgt taaccaccaa      960

cacctgccgg cgcgtcgcgc agagccgcag cgtcacacca tgctgtgcat gtgctgtaaa     1020

tgtgaggccc gtatcgagct ggtcgttgag tctagcgccg acgatctgcg tgcgtttcag     1080

cagctgttcc tgaacacgct gagcttcgtt tgcccgtggt gtgctagcca gcagggcgtg     1140

tctcacgctc agctgccggc acgtcgtgct gagcctcagc gtcacaaaat cctgtgcgtg     1200

tgctgcaaat gcgatggccg catcgaactg accgtggaat ctagcgcaga agacctgcgt     1260

acgctgcagc aactgttcct gagcacgctg tccttcgtat gcccttggtg cgcaactaat     1320

cagatgcacg gtgacacccc gaccctgcac gaatacatgc tggacctgca gccagaaacc     1380

accgatctgt actgttacga acagctgaac atgcatggcc caaaagctac tctgcaggat     1440

atcgtcctgc atctggaacc acagaacgaa atcccggtag atctgctgtg ccatgagcag     1500

ctgatgcatg gtccgcgtga aaccctgcag gaaatcgttc tgcacctgga accgcaaaac     1560

gaactggacc cggttgacct gctgtgctat gaacagctgc cgggcctgcg ccgtccgtcc     1620

ctgggcgcag tcgaacgtca ggactccggc tacgattccc tggatggcgt tggctcccgc     1680

tccttctccc tgggcgaggt ttctgacatg gctgcggtgg aagcggcaga gctggaaatg     1740

acccgtcaag tgctgcacgc gggcgcacgt caggacgatg ctgagccggg cgtgtccggt     1800

gcgtctgcac actggggtca acgtgccctg cagggtgctc aagctgtcgc ggcagcgcag     1860

cgtctggtac atgcgatcgc actgatgacc cagttcggtc gcgcaggttc taccaacact     1920

cctcaggaag cagctagcct gtctgctgct gttttcggtc tgggcgaagc gtcttctgcg     1980

gttgcagaaa ccgtgagcgg tttcttccgt ggttctagcc gctgggcggg tggttttggt     2040

gtagcaggtg gcgctatggc cctgggtggc ggtatcgcgg ctgctgtcgg cgcaggtatg     2100

agcctgaccg acgatgctcc tgcgggccag aaagccgcag ctggcgctga aatcgcgctg     2160

cagctgactg gtggtaccgt tgaactggct agctctatcg cgctggctct ggcagcggca     2220

cgtggcgtga cttctggcct gcaagtcgcc ggtgcctctg cgggcgctgc tgcgggcgct     2280

ctggcagctg cactgtcccc catggaaatc tacggtctgg tacagcagtc tcactacgca     2340

gaccagctgg ataaactggc gcaggagtct tctgcatacg gttacgaagg cgacgcactg     2400

ctggcgcagc tgtatcgtga caaaactgct gctgaaggtg ctgtggcagg cgtttctgcg     2460

gtactgtcta ccgttggcgc tgcggtttct attgcggctg ccgcatccgt tgtaggtgcg     2520

ccggttgctg tagttacctc tctgctgact ggtgcactga acggtatcct gcgtggtgtt     2580

cagcagccta ttatcgaaaa actggcgaat gattatgccc gtaaaatcga cgaactgggc     2640

ggtccgcagg cttattttga aaaaaacctg caggcgcgcc acgaacagct ggcaaacagc     2700

gacggcctgc gcaaaatgct ggcagacctg caagctggtt ggaacgcgtc ttctgtgatc     2760

ggcgtgcaga ccaccgaaat tagcaaatct gcgctggaac tggctgcaat tactggcaac     2820

gcggataacc tgaaaagcgt tgatgttttt gtcgatcgct tcgttcaggg cgagcgcgtt     2880

gctggtcagc cggttgttct ggacgttgcg gcaggcggca tcgacatcgc tagccgcaag     2940

ggcgagcgtc cggctctgac tttcattacc ccgctggcag ctccgggtga agaacagcgt     3000

cgccgtacca agactggtaa aagcgagttc accaccttcg tggaaatcgt aggtaaacag     3060

gaccgctggc gtattcgcga cggtgcggcg gacaccacca tcgacctggc aaaagttgtt     3120

tcccaactgg tagatgctaa cggcgtgctg aaacattcta ttaaactgga tgtaatcggc     3180

ggtgacggcg atgacgttgt actggcgaac gcgtctcgta tccactatga cggcggcgca     3240

ggtaccaaca cggtttccta cgcagcgctg ggccgccagg attccatcac tgttagcgcc     3300

gatggcgaac gtttcaacgt gcgtaaacag ctgaataacg caaacgtcta tcgtgagggt     3360

gtagctaccc agaccaccgc gtacggtaag cgtaccgaaa acgttcagta tcgtcacgtg     3420

gaactggcac gtgtgggtca gctggtagag gtggatacgc tggaacacgt gcagcacatc     3480

atcggtggcg ccggtaacga ttccattact ggtaacgctc acgacaactt cctggcaggt     3540

ggttctggtg atgatcgtct ggacggtggt gcgggtaacg atacgctggt aggcggcgaa     3600

ggtcagaaca ccgtaattgg tggtgccggt gacgacgttt tcctgcagga tctgggcgtt     3660

tggagcaacc agctggatgg cggtgccggt gttgacacgg ttaagtataa cgttcaccag     3720

ccgtctgaag agcgcctgga acgtatgggt gacactggta ttcatgccga tctgcagaaa     3780

ggcactgttg aaaaatggcc tgcgctgaac ctgttctctg tggaccatgt taagaacatt     3840

gaaaacctgc atggctctcg cctgaacgac cgtatcgctg gtgacgacca ggataacgaa     3900

ctgtggggtc atgacggcaa tgataccatt cgcggtcgtg gcggcgacga tattctgcgt     3960

ggcggtctgg gcctggatac cctgtatggt gaagatggta acgatatttt cctgcaagac     4020

gatgaaacgg tatctgatga catcgacggt ggtgcaggcc tggacaccgt agattacagc     4080

gctatgatcc atccgggtcg tatcgtagct ccgcacgagt acggcttcgg tatcgaggcg     4140

gacctgtctc gtgaatgggt tcgtaaagcg tccgcgctgg gtgtggacta ctacgataac     4200

gttcgtaacg tggaaaacgt gatcggtacc tccatgaaag acgtgctgat tggcgacgca     4260

caggccaaca ctctgatggg ccagggcggt gatgacacgg ttcgcggcgg cgacggtgat     4320

gacctgctgt tcggtggtga cggcaacgac atgctgtacg gcgacgcggg caacgacacc     4380

ctgtacggcg gtctgggtga cgacactctg gaaggtggtg caggtaacga ctggttcggc     4440

caaacccagg cacgcgaaca cgacgtgctg cgtggtggcg acggcgtaga caccgtggat     4500

tactcccaaa ctggcgctca cgcgggtatc gcggccggtc gtatcggtct gggcattctg     4560

gccgatctgg gtgccggccg tgtcgacaaa ctgggtgagg ctggctctag cgcctatgat     4620

actgtttccg gcatcgaaaa cgtggtaggc actgaactgg cagatcgtat cacgggtgac     4680

gcgcaagcga acgttctgcg tggtgctggc ggtgcagacg tgctggcggg tggtgaaggc     4740

gacgacgtac tgctgggcgg tgacggtgac gatcagctga gcggtgatgc gggtcgtgac     4800

cgtctgtacg gtgaagcagg tgacgattgg ttcttccagg acgctgctaa cgctggcaac     4860

ctgctggacg gcggcgatgg ccgtgacact gttgacttca gcggtccggg tcgcggtctg     4920

gacgcaggcg cgaaaggcgt tttcctgagc ctgggtaagg gtttcgcatc tctgatggac     4980

gaaccagaaa ccagcaatgt cctgcgtaac atcgaaaacg ctgtcggttc cgcacgcgat     5040

gatgttctga ttggcgatgc tggtgccaat gttctgaacg gtctggcggg taatgatgta     5100

ctgtctggtg gcgctggtga tgatgtcctg ctgggtgatg agggcagcga tctgctgtcc     5160

ggcgatgccg gcaacgacga tctgttcggt ggccaaggtg atgatactta cctgttcggc     5220

gttggctatg gtcatgacac catctatgag tctggtggcg gccacgatac gattcgtatt     5280

aatgcaggtg ctgaccaact gtggtttgca cgtcagggta acgatctgga aattcgcatc     5340

ctgggtactg atgacgctct gaccgtacac gactggtacc gcgatgcgga tcaccgcgta     5400

gaaatcatcc atgcggctaa ccaagctgta gaccaggctg gtattgaaaa actggtagaa     5460

gcgatggcac agtatccgga cccaggtgcg gctgctgcag cacctccagc ggctcgtgtg     5520

ccggataccc tgatgcagag cctggccgtc aattggcgtt aatggatcca ggcctcttta     5580

gaaggagata taccatgctg ccgtctgcac aggcgccgtc tctgctgaat ccaactgatg     5640

acttcgctgc gctgggtaac atcgcgtggc tgtggatgaa cagcccgatg caccgtgact     5700

ggccggttca cctgctggca cgtaacacgc tggcgccgat ccagctgggt caatacatcc     5760

tgctgcgttg taacgacgtg cctgtggcgt attgctcctg ggcactgatg gatgcggata     5820

ccgagctgtc ctacgttatg gccccatcta gcctgggcgg taacgcttgg aactgcggcg     5880

atcgtctgtg gatcattgat tggattgctc cgtttagccg tgacgacaac cgtgctctgc     5940

gtcgcgcgct ggccgaacgt catccggatt ctgttggccg ttccctgcgc gtacgtcgcg     6000

gtggcgacac cgctcgcgtc aaagaatacc gtggtcgtgc tctggacgca gcggcggccc     6060

gcgctcagct ggaccgctac cacgcagaac tgattgccgg tctgcgtgca tccaatggcg     6120

gttatgctcc gcgtggccgt ggcaccgcat aatctagaat tctttaatta aagatccggc     6180

tgctaacaaa gcccgaaagg aagctgagtt ggctgctgcc accgctgagc aatccaggca     6240

tcaaataaaa cgaaaggctc agtcgaaaga ctgggccttt cgttttatct gttgtttgtc     6300

ggtgaacgct ctcctgagta ggacaaatcc gccgggagcg gatttgaacg ttgcgaagca     6360

acggcccgga gggtggcggg caggacgccc gccataaact gccaggcatc aaattaagca     6420

gaaggccatc ctgacggatg gcctttttgc tagcagcacg ccatagtgac tggcgatgct     6480

gtcggaatgg acgatatccc gcaagaggcc cggcagtacc ggcataacca agcctatgcc     6540

tacagcatcc agggtgacgg tgccgaggat gacgatgagc gcattgttag atttcataca     6600

cggtgcctga ctgcgttagc aatttaactg tgataaacta ccgcattaaa gcttatcgat     6660

gataagctgt caaacatgag aattcttaga aaaactcatc gagcatcaaa tgaaactgca     6720

atttattcat atcaggatta tcaataccat atttttgaaa aagccgtttc tgtaatgaag     6780

gagaaaactc accgaggcag ttccatagga tggcaagatc ctggtatcgg tctgcgattc     6840

cgactcgtcc aacatcaata caacctatta atttcccctc gtcaaaaata aggttatcaa     6900

gtgagaaatc accatgagtg acgactgaat ccggtgagaa tggcaaaagc ttatgcattt     6960

ctttccagac ttgttcaaca ggccagccat tacgctcgtc atcaaaatca ctcgcatcaa     7020

ccaaaccgtt attcattcgt gattgcgcct gagcgagacg aaatacgcga tcgctgttaa     7080

aaggacaatt acaaacagga atcgaatgca accggcgcag gaacactgcc agcgcatcaa     7140

caatattttc acctgaatca ggatattctt ctaatacctg gaatgctgtt ttcccgggga     7200

tcgcagtggt gagtaaccat gcatcatcag gagtacggat aaaatgcttg atggtcggaa     7260

gaggcataaa ttccgtcagc cagtttagtc tgaccatctc atctgtaaca tcattggcaa     7320

cgctaccttt gccatgtttc agaaacaact ctggcgcatc gggcttccca tacaatcgat     7380

agattgtcgc acctgattgc ccgacattat cgcgagccca tttataccca tataaatcag     7440

catccatgtt ggaatttaat cgcggcctcg agcaagacgt ttcccgttga atatggctca     7500

taacacccct tgtattactg tttatgtaag cagacagttt tattgttcat gaccaaaatc     7560

ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct     7620

tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta     7680

ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc     7740

ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt aggccaccac     7800

ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct     7860

gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat     7920

aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg     7980

acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa     8040

gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg     8100

gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga     8160

cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc     8220

aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat gttctttcct     8280

gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc tgataccgct     8340

cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga agagcgcctg     8400

atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcaatgg tgcactctca     8460

gtacaatctg ctctgatgcc gcatagttaa gccagtatac actccgctat cgctacgtga     8520

ctgggtcatg gctgcgcccc gacacccgcc aacacccgct gacgcgccct gacgggcttg     8580

tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct gcatgtgtca     8640

gaggttttca ccgtcatcac cgaaacgcgc gaggcagctg cggtaaagct catcagcgtg     8700

gtcgtgaagc gattcacaga tgtctgcctg ttcatccgcg tccagctcgt tgagtttctc     8760

cagaagcgtt aatgtctggc ttctgataaa gcgggccatg ttaagggcgg ttttttcctg     8820

tttggtcact gatgcctccg tgtaaggggg atttctgttc atgggggtaa tgataccgat     8880

gaaacgagag aggatgctca cgatacgggt tactgatgat gaacatgccc ggttactgga     8940

acgttgtgag ggtaaacaac tggcggtatg gatgcggcgg gaccagagaa aaatcactca     9000

gggtcaatgc cagcgcttcg ttaatacaga tgtaggtgtt ccacagggta gccagcagca     9060

tcctgcgatg cagatccgga acataatggt gcagggcgct gacttccgcg tttccagact     9120

ttacgaaaca cggaaaccga agaccattca tgttgttgct caggtcgcag acgttttgca     9180

gcagcagtcg cttcacgttc gctcgcgtat cggtgattca ttctgctaac cagtaaggca     9240

accccgccag cctagccggg tcctcaacga caggagcacg atcatgcgca cccgtggcca     9300

ggacccaacg ctgcccgaga tgcgccgcgt gcggctgctg gagatggcgg acgcgatgga     9360

tatgttctgc caagggttgg tttgcgcatt cacagttctc cgcaagaatt gattggctcc     9420

aattcttgga gtggtgaatc cgttagcgag gtgccgccgg cttccattca ggtcgaggtg     9480

gcccggctcc atgcaccgcg acgcaacgcg gggaggcaga caaggtatag ggcggcgcct     9540

acaatccatg ccaacccgtt ccatgtgctc gccgaggcgg cataaatcgc cgtgacgatc     9600

agcggtccaa tgatcgaagt taggctggta agagccgcga gcgatccttg aagctgtccc     9660

tgatggtcgt catctacctg cctggacagc atggcctgca acgcgggcat cccgatgccg     9720

ccggaagcga gaagaatcat aatggggaag gccatccagc ctcgcgtcgc gaacgccagc     9780

aagacgtagc ccagcgcgtc ggccgccatg ccggcgataa tggcctgctt ctcgccgaaa     9840

cgtttggtgg cgggaccagt gacgaaggct tgagcgaggg cgtgcaagat tccgaatacc     9900

gcaagcgaca ggccgatcat cgtcgcgctc cagcgaaagc ggtcctcgcc gaaaatgacc     9960

cagagcgctg ccggcacctg tcctacgagt tgcatgataa agaagacagt cataagtgcg    10020

gcgacgatag tcatgccccg cgcccaccgg aaggagctga ctgggttgaa ggctctcaag    10080

ggcatcggtc gactcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca    10140

caacatacga gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact    10200

tacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct    10260

gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc gctagcgtgg    10320

tttttctttt caccagtgag acgggcaaca gctgattgcc cttcaccgcc tggccctgag    10380

agagttgcag caagcggtcc acgctggttt gccccagcag gcgaaaatcc tgtttgatgg    10440

tggttaacgg cgggatataa catgagctgt cttcggtatc gtcgtatccc actaccgaga    10500

tatccgcacc aacgcgcagc ccggactcgg taatggcgcg cattgcgccc agcgccatct    10560

gatcgttggc aaccagcatc gcagtgggaa cgatgccctc attcagcatt tgcatggttt    10620

gttgaaaacc ggacatggca ctccagtcgc cttcccgttc cgctatcggc tgaatttgat    10680

tgcgagtgag atatttatgc cagccagcca gacgcagacg cgccgagaca gaacttaatg    10740

ggcccgctaa cagcgcgatt tgctggtgac ccaatgcgac cagatgctcc acgcccagtc    10800

gcgtaccgtc ttcatgggag aaaataatac tgttgatggg tgtctggtca gagacatcaa    10860

gaaataacgc cggaacatta gtgcaggcag cttccacagc aatggcatcc tggtcatcca    10920

gcggatagtt aatgatcagc ccactgacgc gttgcgcgag aagattgtgc accgccgctt    10980

tacaggcttc gacgccgctt cgttctacca tcgacaccac cacgctggca cccagttgat    11040

cggcgcgaga tttaatcgcc gcgacaattt gcgacggcgc gtgcagggcc agactggagg    11100

tggcaacgcc aatcagcaac gactgtttgc ccgccagttg ttgtgccacg cggttgggaa    11160

tgtaattcag ctccgccatc gccgcttcca ctttttcccg cgttttcgca gaaacgtggc    11220

tggcctggtt caccacgcgg gaaacggtct gataagagac accggcatac tctgcgacat    11280

cgtataacgt tactggtttc acattcacca ccctgaattg actctcttcc gggcgctatc    11340

atgccatacc gcgaaaggtt ttgcgccatt cgatggtgtc ggaatttatg cggtgtgaaa    11400

taccgcacag atgcgtaagg agaaaatacc gcatcaggcg ctcttccgct tcctcgctca    11460

ctgactcgct gccaccccgt ggcatgcaag gagatggcgc ccaacagtcc cccggccacg    11520

gggcctgcca ccatacccac gccgaaacaa gcgctcatga gcccgaagtg gcgagcccga    11580

tcttccccat cggtgatgtc ggcgatatag gcgccagcaa ccgcacctgt ggcgccggtg    11640

atgccggcca cgatgcgtcc ggcgtagagg                                     11670


<210>  63
<211>  5775
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide encoding chimeric CyaA delta 93+ antigen HPV16, HVP18 
       and HPV45 full


<220>
<221>  CDS
<222>  (1)..(5775)

<400>  63
atg cag cag tcc cat cag gcc ggt tac gca aac gca gcc gat cgt gaa         48
Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu           
1               5                   10                  15                

tct ggt atc ccg gca gcg gtt ctg gat ggt att aag gca gtt gcc aaa         96
Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys           
            20                  25                  30                    

gag aag aac gct acc ctg atg ttc cgt ctg gtc aac cca cac tct act        144
Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr           
        35                  40                  45                        

tcc ctg atc gcg gaa ggt gtg gcg acc aaa ggc ctg ggt gtg cac gcc        192
Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala           
    50                  55                  60                            

aaa agc agc gac tgg ggt ctg cag gca ggt tat att ccg gtg aac ccg        240
Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro           
65                  70                  75                  80            

aat ctg tct aaa ctg ttc ggt cgt gcc ccg gag gtg atc gca cgt gca        288
Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala           
                85                  90                  95                

gac aac gat gtc aac tct tct ctg gcg cat ggt cac acc gcg gtt gat        336
Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp           
            100                 105                 110                   

ctg acc ctg tcc aaa gaa cgc ctg gat tac ctg cgt cag gcg ggc ctg        384
Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu           
        115                 120                 125                       

gtg acg ggc atg gcc gac ggt gtt gta gcg agc aac cac gcg ggt tat        432
Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr           
    130                 135                 140                           

gaa caa ttt gag ttt cgc gtt aaa gag acc tct gac ggt cgt tac gcg        480
Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala           
145                 150                 155                 160           

gtg cag tac cgc cgc aaa ggt ggc gat gac ttt gaa gct gtc aaa gtg        528
Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val           
                165                 170                 175               

atc ggt aac gct gct gga att ccg ctg acc gcg gat atc gac atg ttt        576
Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe           
            180                 185                 190                   

gcc atc atg cct cac ctg tcc aac ttt cgc gat tcc gca cgc agc tct        624
Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser           
        195                 200                 205                       

gtg acg tct ggt gat tcc gtc act gac tac ctg gct cgt acc cgt cgt        672
Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg           
    210                 215                 220                           

gcg gcc tct gaa gac gaa atc gac ggc cct gcg ggc cag gct gaa cca        720
Ala Ala Ser Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro           
225                 230                 235                 240           

gat cgt gct cac tac aac atc gta act ttt tgc tgt aag tgc gat agc        768
Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser           
                245                 250                 255               

act ctg cgt ctg tgc gta cag tct act cac gtt gat atc cgc act ctg        816
Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu           
            260                 265                 270                   

gaa gat ctg ctg atg ggt acc ctg ggt atc gtc tgc cca atc tgc tct        864
Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser           
        275                 280                 285                       

caa aag cct gct tct ggt gtt aac cat cag cac ctg ccg gct cgt cgc        912
Gln Lys Pro Ala Ser Gly Val Asn His Gln His Leu Pro Ala Arg Arg           
    290                 295                 300                           

gct gaa cca cag cgt cac acg atg ctg tgc atg tgt tgc aaa tgc gag        960
Ala Glu Pro Gln Arg His Thr Met Leu Cys Met Cys Cys Lys Cys Glu           
305                 310                 315                 320           

gct cgc atc gaa ctg gtt gtt gaa tcc agc gct gac gac ctg cgt gcg       1008
Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala           
                325                 330                 335               

ttt cag caa ctg ttc ctg aac acg ctg tct ttt gtt tgt ccg tgg tgt       1056
Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe Val Cys Pro Trp Cys           
            340                 345                 350                   

gcc tcc cag cag gag aac gat gaa gcg gat ggc gtg tcc cac gcg cag       1104
Ala Ser Gln Gln Glu Asn Asp Glu Ala Asp Gly Val Ser His Ala Gln           
        355                 360                 365                       

ctg ccg gca cgt cgt gca gaa ccg cag cgc cac aag att ctg tgc gtt       1152
Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys Val           
    370                 375                 380                           

tgc tgt aaa tgt gat ggc cgt atc gaa ctg act gtg gaa tcc tcc gcg       1200
Cys Cys Lys Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser Ala           
385                 390                 395                 400           

gaa gat ctg cgt acg ctg cag cag ctg ttc ctg tct acc ctg tct ttc       1248
Glu Asp Leu Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe           
                405                 410                 415               

gtg tgc ccg tgg tgc gcc acc aat caa atg cac ggc gac acc ccg acc       1296
Val Cys Pro Trp Cys Ala Thr Asn Gln Met His Gly Asp Thr Pro Thr           
            420                 425                 430                   

ctg cac gaa tac atg ctg gac ctg cag ccg gaa acc acg gat ctg tat       1344
Leu His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr           
        435                 440                 445                       

tgt tat gaa cag ctg aac gat agc agc gag gaa atg cac ggt ccg aaa       1392
Cys Tyr Glu Gln Leu Asn Asp Ser Ser Glu Glu Met His Gly Pro Lys           
    450                 455                 460                           

gca act ctg cag gac att gtg ctg cat ctg gag cca cag aac gaa atc       1440
Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu Ile           
465                 470                 475                 480           

ccg gtt gat ctg ctg tgc cac gag caa ctg agc gat tcc gaa gag gaa       1488
Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser Asp Ser Glu Glu Glu           
                485                 490                 495               

aac gac gaa att gat atg cat ggt ccg cgc gag acc ctg caa gaa atc       1536
Asn Asp Glu Ile Asp Met His Gly Pro Arg Glu Thr Leu Gln Glu Ile           
            500                 505                 510                   

gtc ctg cac ctg gaa ccg caa aac gaa ctg gac cct gta gac ctg ctg       1584
Val Leu His Leu Glu Pro Gln Asn Glu Leu Asp Pro Val Asp Leu Leu           
        515                 520                 525                       

tgc tac gaa cag ctg tcc gaa tct gaa gaa gaa tcc cag atg ctg act       1632
Cys Tyr Glu Gln Leu Ser Glu Ser Glu Glu Glu Ser Gln Met Leu Thr           
    530                 535                 540                           

cgt ggc cag ctg aaa gaa tac atc ggc caa cag cgt ggc gaa ggc tac       1680
Arg Gly Gln Leu Lys Glu Tyr Ile Gly Gln Gln Arg Gly Glu Gly Tyr           
545                 550                 555                 560           

gtt ttc tac gag aat cgt gct tac ggc gtt gcg ggc aaa tcc ctg ttc       1728
Val Phe Tyr Glu Asn Arg Ala Tyr Gly Val Ala Gly Lys Ser Leu Phe           
                565                 570                 575               

gac gat ggt ctg ggc gct gca ccg ggc gtt ccg agc ggc cgt tct aaa       1776
Asp Asp Gly Leu Gly Ala Ala Pro Gly Val Pro Ser Gly Arg Ser Lys           
            580                 585                 590                   

ttc agc ccg gac gta ctg gaa act gtg ccg gct tcc ccg ggc ctg cgc       1824
Phe Ser Pro Asp Val Leu Glu Thr Val Pro Ala Ser Pro Gly Leu Arg           
        595                 600                 605                       

cgt ccg tcc ctg ggc gca gtc gaa cgt cag gac tcc ggc tac gat tcc       1872
Arg Pro Ser Leu Gly Ala Val Glu Arg Gln Asp Ser Gly Tyr Asp Ser           
    610                 615                 620                           

ctg gat ggc gtt ggc tcc cgc tcc ttc tcc ctg ggc gag gtt tct gac       1920
Leu Asp Gly Val Gly Ser Arg Ser Phe Ser Leu Gly Glu Val Ser Asp           
625                 630                 635                 640           

atg gct gcg gtg gaa gcg gca gag ctg gaa atg acc cgt caa gtg ctg       1968
Met Ala Ala Val Glu Ala Ala Glu Leu Glu Met Thr Arg Gln Val Leu           
                645                 650                 655               

cac gcg ggc gca cgt cag gac gat gct gag ccg ggc gtg tcc ggt gcg       2016
His Ala Gly Ala Arg Gln Asp Asp Ala Glu Pro Gly Val Ser Gly Ala           
            660                 665                 670                   

tct gca cac tgg ggt caa cgt gcc ctg cag ggt gct caa gct gtc gcg       2064
Ser Ala His Trp Gly Gln Arg Ala Leu Gln Gly Ala Gln Ala Val Ala           
        675                 680                 685                       

gca gcg cag cgt ctg gta cat gcg atc gca ctg atg acc cag ttc ggt       2112
Ala Ala Gln Arg Leu Val His Ala Ile Ala Leu Met Thr Gln Phe Gly           
    690                 695                 700                           

cgc gca ggt tct acc aac act cct cag gaa gca gct agc ctg tct gct       2160
Arg Ala Gly Ser Thr Asn Thr Pro Gln Glu Ala Ala Ser Leu Ser Ala           
705                 710                 715                 720           

gct gtt ttc ggt ctg ggc gaa gcg tct tct gcg gtt gca gaa acc gtg       2208
Ala Val Phe Gly Leu Gly Glu Ala Ser Ser Ala Val Ala Glu Thr Val           
                725                 730                 735               

agc ggt ttc ttc cgt ggt tct agc cgc tgg gcg ggt ggt ttt ggt gta       2256
Ser Gly Phe Phe Arg Gly Ser Ser Arg Trp Ala Gly Gly Phe Gly Val           
            740                 745                 750                   

gca ggt ggc gct atg gcc ctg ggt ggc ggt atc gcg gct gct gtc ggc       2304
Ala Gly Gly Ala Met Ala Leu Gly Gly Gly Ile Ala Ala Ala Val Gly           
        755                 760                 765                       

gca ggt atg agc ctg acc gac gat gct cct gcg ggc cag aaa gcc gca       2352
Ala Gly Met Ser Leu Thr Asp Asp Ala Pro Ala Gly Gln Lys Ala Ala           
    770                 775                 780                           

gct ggc gct gaa atc gcg ctg cag ctg act ggt ggt acc gtt gaa ctg       2400
Ala Gly Ala Glu Ile Ala Leu Gln Leu Thr Gly Gly Thr Val Glu Leu           
785                 790                 795                 800           

gct agc tct atc gcg ctg gct ctg gca gcg gca cgt ggc gtg act tct       2448
Ala Ser Ser Ile Ala Leu Ala Leu Ala Ala Ala Arg Gly Val Thr Ser           
                805                 810                 815               

ggc ctg caa gtc gcc ggt gcc tct gcg ggc gct gct gcg ggc gct ctg       2496
Gly Leu Gln Val Ala Gly Ala Ser Ala Gly Ala Ala Ala Gly Ala Leu           
            820                 825                 830                   

gca gct gca ctg tcc ccc atg gaa atc tac ggt ctg gta cag cag tct       2544
Ala Ala Ala Leu Ser Pro Met Glu Ile Tyr Gly Leu Val Gln Gln Ser           
        835                 840                 845                       

cac tac gca gac cag ctg gat aaa ctg gcg cag gag tct tct gca tac       2592
His Tyr Ala Asp Gln Leu Asp Lys Leu Ala Gln Glu Ser Ser Ala Tyr           
    850                 855                 860                           

ggt tac gaa ggc gac gca ctg ctg gcg cag ctg tat cgt gac aaa act       2640
Gly Tyr Glu Gly Asp Ala Leu Leu Ala Gln Leu Tyr Arg Asp Lys Thr           
865                 870                 875                 880           

gct gct gaa ggt gct gtg gca ggc gtt tct gcg gta ctg tct acc gtt       2688
Ala Ala Glu Gly Ala Val Ala Gly Val Ser Ala Val Leu Ser Thr Val           
                885                 890                 895               

ggc gct gcg gtt tct att gcg gct gcc gca tcc gtt gta ggt gcg ccg       2736
Gly Ala Ala Val Ser Ile Ala Ala Ala Ala Ser Val Val Gly Ala Pro           
            900                 905                 910                   

gtt gct gta gtt acc tct ctg ctg act ggt gca ctg aac ggt atc ctg       2784
Val Ala Val Val Thr Ser Leu Leu Thr Gly Ala Leu Asn Gly Ile Leu           
        915                 920                 925                       

cgt ggt gtt cag cag cct att atc gaa aaa ctg gcg aat gat tat gcc       2832
Arg Gly Val Gln Gln Pro Ile Ile Glu Lys Leu Ala Asn Asp Tyr Ala           
    930                 935                 940                           

cgt aaa atc gac gaa ctg ggc ggt ccg cag gct tat ttt gaa aaa aac       2880
Arg Lys Ile Asp Glu Leu Gly Gly Pro Gln Ala Tyr Phe Glu Lys Asn           
945                 950                 955                 960           

ctg cag gcg cgc cac gaa cag ctg gca aac agc gac ggc ctg cgc aaa       2928
Leu Gln Ala Arg His Glu Gln Leu Ala Asn Ser Asp Gly Leu Arg Lys           
                965                 970                 975               

atg ctg gca gac ctg caa gct ggt tgg aac gcg tct tct gtg atc ggc       2976
Met Leu Ala Asp Leu Gln Ala Gly Trp Asn Ala Ser Ser Val Ile Gly           
            980                 985                 990                   

gtg cag acc acc gaa att agc aaa  tct gcg ctg gaa ctg  gct gca att     3024
Val Gln Thr Thr Glu Ile Ser Lys  Ser Ala Leu Glu Leu  Ala Ala Ile         
        995                 1000                 1005                     

act ggc  aac gcg gat aac ctg  aaa agc gtt gat gtt  ttt gtc gat        3069
Thr Gly  Asn Ala Asp Asn Leu  Lys Ser Val Asp Val  Phe Val Asp            
    1010                 1015                 1020                        

cgc ttc  gtt cag ggc gag cgc  gtt gct ggt cag ccg  gtt gtt ctg        3114
Arg Phe  Val Gln Gly Glu Arg  Val Ala Gly Gln Pro  Val Val Leu            
    1025                 1030                 1035                        

gac gtt  gcg gca ggc ggc atc  gac atc gct agc cgc  aag ggc gag        3159
Asp Val  Ala Ala Gly Gly Ile  Asp Ile Ala Ser Arg  Lys Gly Glu            
    1040                 1045                 1050                        

cgt ccg  gct ctg act ttc att  acc ccg ctg gca gct  ccg ggt gaa        3204
Arg Pro  Ala Leu Thr Phe Ile  Thr Pro Leu Ala Ala  Pro Gly Glu            
    1055                 1060                 1065                        

gaa cag  cgt cgc cgt acc aag  act ggt aaa agc gag  ttc acc acc        3249
Glu Gln  Arg Arg Arg Thr Lys  Thr Gly Lys Ser Glu  Phe Thr Thr            
    1070                 1075                 1080                        

ttc gtg  gaa atc gta ggt aaa  cag gac cgc tgg cgt  att cgc gac        3294
Phe Val  Glu Ile Val Gly Lys  Gln Asp Arg Trp Arg  Ile Arg Asp            
    1085                 1090                 1095                        

ggt gcg  gcg gac acc acc atc  gac ctg gca aaa gtt  gtt tcc caa        3339
Gly Ala  Ala Asp Thr Thr Ile  Asp Leu Ala Lys Val  Val Ser Gln            
    1100                 1105                 1110                        

ctg gta  gat gct aac ggc gtg  ctg aaa cat tct att  aaa ctg gat        3384
Leu Val  Asp Ala Asn Gly Val  Leu Lys His Ser Ile  Lys Leu Asp            
    1115                 1120                 1125                        

gta atc  ggc ggt gac ggc gat  gac gtt gta ctg gcg  aac gcg tct        3429
Val Ile  Gly Gly Asp Gly Asp  Asp Val Val Leu Ala  Asn Ala Ser            
    1130                 1135                 1140                        

cgt atc  cac tat gac ggc ggc  gca ggt acc aac acg  gtt tcc tac        3474
Arg Ile  His Tyr Asp Gly Gly  Ala Gly Thr Asn Thr  Val Ser Tyr            
    1145                 1150                 1155                        

gca gcg  ctg ggc cgc cag gat  tcc atc act gtt agc  gcc gat ggc        3519
Ala Ala  Leu Gly Arg Gln Asp  Ser Ile Thr Val Ser  Ala Asp Gly            
    1160                 1165                 1170                        

gaa cgt  ttc aac gtg cgt aaa  cag ctg aat aac gca  aac gtc tat        3564
Glu Arg  Phe Asn Val Arg Lys  Gln Leu Asn Asn Ala  Asn Val Tyr            
    1175                 1180                 1185                        

cgt gag  ggt gta gct acc cag  acc acc gcg tac ggt  aag cgt acc        3609
Arg Glu  Gly Val Ala Thr Gln  Thr Thr Ala Tyr Gly  Lys Arg Thr            
    1190                 1195                 1200                        

gaa aac  gtt cag tat cgt cac  gtg gaa ctg gca cgt  gtg ggt cag        3654
Glu Asn  Val Gln Tyr Arg His  Val Glu Leu Ala Arg  Val Gly Gln            
    1205                 1210                 1215                        

ctg gta  gag gtg gat acg ctg  gaa cac gtg cag cac  atc atc ggt        3699
Leu Val  Glu Val Asp Thr Leu  Glu His Val Gln His  Ile Ile Gly            
    1220                 1225                 1230                        

ggc gcc  ggt aac gat tcc att  act ggt aac gct cac  gac aac ttc        3744
Gly Ala  Gly Asn Asp Ser Ile  Thr Gly Asn Ala His  Asp Asn Phe            
    1235                 1240                 1245                        

ctg gca  ggt ggt tct ggt gat  gat cgt ctg gac ggt  ggt gcg ggt        3789
Leu Ala  Gly Gly Ser Gly Asp  Asp Arg Leu Asp Gly  Gly Ala Gly            
    1250                 1255                 1260                        

aac gat  acg ctg gta ggc ggc  gaa ggt cag aac acc  gta att ggt        3834
Asn Asp  Thr Leu Val Gly Gly  Glu Gly Gln Asn Thr  Val Ile Gly            
    1265                 1270                 1275                        

ggt gcc  ggt gac gac gtt ttc  ctg cag gat ctg ggc  gtt tgg agc        3879
Gly Ala  Gly Asp Asp Val Phe  Leu Gln Asp Leu Gly  Val Trp Ser            
    1280                 1285                 1290                        

aac cag  ctg gat ggc ggt gcc  ggt gtt gac acg gtt  aag tat aac        3924
Asn Gln  Leu Asp Gly Gly Ala  Gly Val Asp Thr Val  Lys Tyr Asn            
    1295                 1300                 1305                        

gtt cac  cag ccg tct gaa gag  cgc ctg gaa cgt atg  ggt gac act        3969
Val His  Gln Pro Ser Glu Glu  Arg Leu Glu Arg Met  Gly Asp Thr            
    1310                 1315                 1320                        

ggt att  cat gcc gat ctg cag  aaa ggc act gtt gaa  aaa tgg cct        4014
Gly Ile  His Ala Asp Leu Gln  Lys Gly Thr Val Glu  Lys Trp Pro            
    1325                 1330                 1335                        

gcg ctg  aac ctg ttc tct gtg  gac cat gtt aag aac  att gaa aac        4059
Ala Leu  Asn Leu Phe Ser Val  Asp His Val Lys Asn  Ile Glu Asn            
    1340                 1345                 1350                        

ctg cat  ggc tct cgc ctg aac  gac cgt atc gct ggt  gac gac cag        4104
Leu His  Gly Ser Arg Leu Asn  Asp Arg Ile Ala Gly  Asp Asp Gln            
    1355                 1360                 1365                        

gat aac  gaa ctg tgg ggt cat  gac ggc aat gat acc  att cgc ggt        4149
Asp Asn  Glu Leu Trp Gly His  Asp Gly Asn Asp Thr  Ile Arg Gly            
    1370                 1375                 1380                        

cgt ggc  ggc gac gat att ctg  cgt ggc ggt ctg ggc  ctg gat acc        4194
Arg Gly  Gly Asp Asp Ile Leu  Arg Gly Gly Leu Gly  Leu Asp Thr            
    1385                 1390                 1395                        

ctg tat  ggt gaa gat ggt aac  gat att ttc ctg caa  gac gat gaa        4239
Leu Tyr  Gly Glu Asp Gly Asn  Asp Ile Phe Leu Gln  Asp Asp Glu            
    1400                 1405                 1410                        

acg gta  tct gat gac atc gac  ggt ggt gca ggc ctg  gac acc gta        4284
Thr Val  Ser Asp Asp Ile Asp  Gly Gly Ala Gly Leu  Asp Thr Val            
    1415                 1420                 1425                        

gat tac  agc gct atg atc cat  ccg ggt cgt atc gta  gct ccg cac        4329
Asp Tyr  Ser Ala Met Ile His  Pro Gly Arg Ile Val  Ala Pro His            
    1430                 1435                 1440                        

gag tac  ggc ttc ggt atc gag  gcg gac ctg tct cgt  gaa tgg gtt        4374
Glu Tyr  Gly Phe Gly Ile Glu  Ala Asp Leu Ser Arg  Glu Trp Val            
    1445                 1450                 1455                        

cgt aaa  gcg tcc gcg ctg ggt  gtg gac tac tac gat  aac gtt cgt        4419
Arg Lys  Ala Ser Ala Leu Gly  Val Asp Tyr Tyr Asp  Asn Val Arg            
    1460                 1465                 1470                        

aac gtg  gaa aac gtg atc ggt  acc tcc atg aaa gac  gtg ctg att        4464
Asn Val  Glu Asn Val Ile Gly  Thr Ser Met Lys Asp  Val Leu Ile            
    1475                 1480                 1485                        

ggc gac  gca cag gcc aac act  ctg atg ggc cag ggc  ggt gat gac        4509
Gly Asp  Ala Gln Ala Asn Thr  Leu Met Gly Gln Gly  Gly Asp Asp            
    1490                 1495                 1500                        

acg gtt  cgc ggc ggc gac ggt  gat gac ctg ctg ttc  ggt ggt gac        4554
Thr Val  Arg Gly Gly Asp Gly  Asp Asp Leu Leu Phe  Gly Gly Asp            
    1505                 1510                 1515                        

ggc aac  gac atg ctg tac ggc  gac gcg ggc aac gac  acc ctg tac        4599
Gly Asn  Asp Met Leu Tyr Gly  Asp Ala Gly Asn Asp  Thr Leu Tyr            
    1520                 1525                 1530                        

ggc ggt  ctg ggt gac gac act  ctg gaa ggt ggt gca  ggt aac gac        4644
Gly Gly  Leu Gly Asp Asp Thr  Leu Glu Gly Gly Ala  Gly Asn Asp            
    1535                 1540                 1545                        

tgg ttc  ggc caa acc cag gca  cgc gaa cac gac gtg  ctg cgt ggt        4689
Trp Phe  Gly Gln Thr Gln Ala  Arg Glu His Asp Val  Leu Arg Gly            
    1550                 1555                 1560                        

ggc gac  ggc gta gac acc gtg  gat tac tcc caa act  ggc gct cac        4734
Gly Asp  Gly Val Asp Thr Val  Asp Tyr Ser Gln Thr  Gly Ala His            
    1565                 1570                 1575                        

gcg ggt  atc gcg gcc ggt cgt  atc ggt ctg ggc att  ctg gcc gat        4779
Ala Gly  Ile Ala Ala Gly Arg  Ile Gly Leu Gly Ile  Leu Ala Asp            
    1580                 1585                 1590                        

ctg ggt  gcc ggc cgt gtc gac  aaa ctg ggt gag gct  ggc tct agc        4824
Leu Gly  Ala Gly Arg Val Asp  Lys Leu Gly Glu Ala  Gly Ser Ser            
    1595                 1600                 1605                        

gcc tat  gat act gtt tcc ggc  atc gaa aac gtg gta  ggc act gaa        4869
Ala Tyr  Asp Thr Val Ser Gly  Ile Glu Asn Val Val  Gly Thr Glu            
    1610                 1615                 1620                        

ctg gca  gat cgt atc acg ggt  gac gcg caa gcg aac  gtt ctg cgt        4914
Leu Ala  Asp Arg Ile Thr Gly  Asp Ala Gln Ala Asn  Val Leu Arg            
    1625                 1630                 1635                        

ggt gct  ggc ggt gca gac gtg  ctg gcg ggt ggt gaa  ggc gac gac        4959
Gly Ala  Gly Gly Ala Asp Val  Leu Ala Gly Gly Glu  Gly Asp Asp            
    1640                 1645                 1650                        

gta ctg  ctg ggc ggt gac ggt  gac gat cag ctg agc  ggt gat gcg        5004
Val Leu  Leu Gly Gly Asp Gly  Asp Asp Gln Leu Ser  Gly Asp Ala            
    1655                 1660                 1665                        

ggt cgt  gac cgt ctg tac ggt  gaa gca ggt gac gat  tgg ttc ttc        5049
Gly Arg  Asp Arg Leu Tyr Gly  Glu Ala Gly Asp Asp  Trp Phe Phe            
    1670                 1675                 1680                        

cag gac  gct gct aac gct ggc  aac ctg ctg gac ggc  ggc gat ggc        5094
Gln Asp  Ala Ala Asn Ala Gly  Asn Leu Leu Asp Gly  Gly Asp Gly            
    1685                 1690                 1695                        

cgt gac  act gtt gac ttc agc  ggt ccg ggt cgc ggt  ctg gac gca        5139
Arg Asp  Thr Val Asp Phe Ser  Gly Pro Gly Arg Gly  Leu Asp Ala            
    1700                 1705                 1710                        

ggc gcg  aaa ggc gtt ttc ctg  agc ctg ggt aag ggt  ttc gca tct        5184
Gly Ala  Lys Gly Val Phe Leu  Ser Leu Gly Lys Gly  Phe Ala Ser            
    1715                 1720                 1725                        

ctg atg  gac gaa cca gaa acc  agc aat gtc ctg cgt  aac atc gaa        5229
Leu Met  Asp Glu Pro Glu Thr  Ser Asn Val Leu Arg  Asn Ile Glu            
    1730                 1735                 1740                        

aac gct  gtc ggt tcc gca cgc  gat gat gtt ctg att  ggc gat gct        5274
Asn Ala  Val Gly Ser Ala Arg  Asp Asp Val Leu Ile  Gly Asp Ala            
    1745                 1750                 1755                        

ggt gcc  aat gtt ctg aac ggt  ctg gcg ggt aat gat  gta ctg tct        5319
Gly Ala  Asn Val Leu Asn Gly  Leu Ala Gly Asn Asp  Val Leu Ser            
    1760                 1765                 1770                        

ggt ggc  gct ggt gat gat gtc  ctg ctg ggt gat gag  ggc agc gat        5364
Gly Gly  Ala Gly Asp Asp Val  Leu Leu Gly Asp Glu  Gly Ser Asp            
    1775                 1780                 1785                        

ctg ctg  tcc ggc gat gcc ggc  aac gac gat ctg ttc  ggt ggc caa        5409
Leu Leu  Ser Gly Asp Ala Gly  Asn Asp Asp Leu Phe  Gly Gly Gln            
    1790                 1795                 1800                        

ggt gat  gat act tac ctg ttc  ggc gtt ggc tat ggt  cat gac acc        5454
Gly Asp  Asp Thr Tyr Leu Phe  Gly Val Gly Tyr Gly  His Asp Thr            
    1805                 1810                 1815                        

atc tat  gag tct ggt ggc ggc  cac gat acg att cgt  att aat gca        5499
Ile Tyr  Glu Ser Gly Gly Gly  His Asp Thr Ile Arg  Ile Asn Ala            
    1820                 1825                 1830                        

ggt gct  gac caa ctg tgg ttt  gca cgt cag ggt aac  gat ctg gaa        5544
Gly Ala  Asp Gln Leu Trp Phe  Ala Arg Gln Gly Asn  Asp Leu Glu            
    1835                 1840                 1845                        

att cgc  atc ctg ggt act gat  gac gct ctg acc gta  cac gac tgg        5589
Ile Arg  Ile Leu Gly Thr Asp  Asp Ala Leu Thr Val  His Asp Trp            
    1850                 1855                 1860                        

tac cgc  gat gcg gat cac cgc  gta gaa atc atc cat  gcg gct aac        5634
Tyr Arg  Asp Ala Asp His Arg  Val Glu Ile Ile His  Ala Ala Asn            
    1865                 1870                 1875                        

caa gct  gta gac cag gct ggt  att gaa aaa ctg gta  gaa gcg atg        5679
Gln Ala  Val Asp Gln Ala Gly  Ile Glu Lys Leu Val  Glu Ala Met            
    1880                 1885                 1890                        

gca cag  tat ccg gac cca ggt  gcg gct gct gca gca  cct cca gcg        5724
Ala Gln  Tyr Pro Asp Pro Gly  Ala Ala Ala Ala Ala  Pro Pro Ala            
    1895                 1900                 1905                        

gct cgt  gtg ccg gat acc ctg  atg cag agc ctg gcc  gtc aat tgg        5769
Ala Arg  Val Pro Asp Thr Leu  Met Gln Ser Leu Ala  Val Asn Trp            
    1910                 1915                 1920                        

cgt taa                                                               5775
Arg                                                                       
                                                                          


<210>  64
<211>  1924
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  64

Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu 
1               5                   10                  15      


Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys 
            20                  25                  30          


Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr 
        35                  40                  45              


Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala 
    50                  55                  60                  


Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro 
65                  70                  75                  80  


Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala 
                85                  90                  95      


Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp 
            100                 105                 110         


Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu 
        115                 120                 125             


Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr 
    130                 135                 140                 


Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala 
145                 150                 155                 160 


Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val 
                165                 170                 175     


Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe 
            180                 185                 190         


Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser 
        195                 200                 205             


Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg 
    210                 215                 220                 


Ala Ala Ser Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro 
225                 230                 235                 240 


Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser 
                245                 250                 255     


Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu 
            260                 265                 270         


Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser 
        275                 280                 285             


Gln Lys Pro Ala Ser Gly Val Asn His Gln His Leu Pro Ala Arg Arg 
    290                 295                 300                 


Ala Glu Pro Gln Arg His Thr Met Leu Cys Met Cys Cys Lys Cys Glu 
305                 310                 315                 320 


Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala 
                325                 330                 335     


Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe Val Cys Pro Trp Cys 
            340                 345                 350         


Ala Ser Gln Gln Glu Asn Asp Glu Ala Asp Gly Val Ser His Ala Gln 
        355                 360                 365             


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys Val 
    370                 375                 380                 


Cys Cys Lys Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser Ala 
385                 390                 395                 400 


Glu Asp Leu Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe 
                405                 410                 415     


Val Cys Pro Trp Cys Ala Thr Asn Gln Met His Gly Asp Thr Pro Thr 
            420                 425                 430         


Leu His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr 
        435                 440                 445             


Cys Tyr Glu Gln Leu Asn Asp Ser Ser Glu Glu Met His Gly Pro Lys 
    450                 455                 460                 


Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu Ile 
465                 470                 475                 480 


Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser Asp Ser Glu Glu Glu 
                485                 490                 495     


Asn Asp Glu Ile Asp Met His Gly Pro Arg Glu Thr Leu Gln Glu Ile 
            500                 505                 510         


Val Leu His Leu Glu Pro Gln Asn Glu Leu Asp Pro Val Asp Leu Leu 
        515                 520                 525             


Cys Tyr Glu Gln Leu Ser Glu Ser Glu Glu Glu Ser Gln Met Leu Thr 
    530                 535                 540                 


Arg Gly Gln Leu Lys Glu Tyr Ile Gly Gln Gln Arg Gly Glu Gly Tyr 
545                 550                 555                 560 


Val Phe Tyr Glu Asn Arg Ala Tyr Gly Val Ala Gly Lys Ser Leu Phe 
                565                 570                 575     


Asp Asp Gly Leu Gly Ala Ala Pro Gly Val Pro Ser Gly Arg Ser Lys 
            580                 585                 590         


Phe Ser Pro Asp Val Leu Glu Thr Val Pro Ala Ser Pro Gly Leu Arg 
        595                 600                 605             


Arg Pro Ser Leu Gly Ala Val Glu Arg Gln Asp Ser Gly Tyr Asp Ser 
    610                 615                 620                 


Leu Asp Gly Val Gly Ser Arg Ser Phe Ser Leu Gly Glu Val Ser Asp 
625                 630                 635                 640 


Met Ala Ala Val Glu Ala Ala Glu Leu Glu Met Thr Arg Gln Val Leu 
                645                 650                 655     


His Ala Gly Ala Arg Gln Asp Asp Ala Glu Pro Gly Val Ser Gly Ala 
            660                 665                 670         


Ser Ala His Trp Gly Gln Arg Ala Leu Gln Gly Ala Gln Ala Val Ala 
        675                 680                 685             


Ala Ala Gln Arg Leu Val His Ala Ile Ala Leu Met Thr Gln Phe Gly 
    690                 695                 700                 


Arg Ala Gly Ser Thr Asn Thr Pro Gln Glu Ala Ala Ser Leu Ser Ala 
705                 710                 715                 720 


Ala Val Phe Gly Leu Gly Glu Ala Ser Ser Ala Val Ala Glu Thr Val 
                725                 730                 735     


Ser Gly Phe Phe Arg Gly Ser Ser Arg Trp Ala Gly Gly Phe Gly Val 
            740                 745                 750         


Ala Gly Gly Ala Met Ala Leu Gly Gly Gly Ile Ala Ala Ala Val Gly 
        755                 760                 765             


Ala Gly Met Ser Leu Thr Asp Asp Ala Pro Ala Gly Gln Lys Ala Ala 
    770                 775                 780                 


Ala Gly Ala Glu Ile Ala Leu Gln Leu Thr Gly Gly Thr Val Glu Leu 
785                 790                 795                 800 


Ala Ser Ser Ile Ala Leu Ala Leu Ala Ala Ala Arg Gly Val Thr Ser 
                805                 810                 815     


Gly Leu Gln Val Ala Gly Ala Ser Ala Gly Ala Ala Ala Gly Ala Leu 
            820                 825                 830         


Ala Ala Ala Leu Ser Pro Met Glu Ile Tyr Gly Leu Val Gln Gln Ser 
        835                 840                 845             


His Tyr Ala Asp Gln Leu Asp Lys Leu Ala Gln Glu Ser Ser Ala Tyr 
    850                 855                 860                 


Gly Tyr Glu Gly Asp Ala Leu Leu Ala Gln Leu Tyr Arg Asp Lys Thr 
865                 870                 875                 880 


Ala Ala Glu Gly Ala Val Ala Gly Val Ser Ala Val Leu Ser Thr Val 
                885                 890                 895     


Gly Ala Ala Val Ser Ile Ala Ala Ala Ala Ser Val Val Gly Ala Pro 
            900                 905                 910         


Val Ala Val Val Thr Ser Leu Leu Thr Gly Ala Leu Asn Gly Ile Leu 
        915                 920                 925             


Arg Gly Val Gln Gln Pro Ile Ile Glu Lys Leu Ala Asn Asp Tyr Ala 
    930                 935                 940                 


Arg Lys Ile Asp Glu Leu Gly Gly Pro Gln Ala Tyr Phe Glu Lys Asn 
945                 950                 955                 960 


Leu Gln Ala Arg His Glu Gln Leu Ala Asn Ser Asp Gly Leu Arg Lys 
                965                 970                 975     


Met Leu Ala Asp Leu Gln Ala Gly Trp Asn Ala Ser Ser Val Ile Gly 
            980                 985                 990         


Val Gln Thr Thr Glu Ile Ser Lys  Ser Ala Leu Glu Leu  Ala Ala Ile 
        995                 1000                 1005             


Thr Gly  Asn Ala Asp Asn Leu  Lys Ser Val Asp Val  Phe Val Asp 
    1010                 1015                 1020             


Arg Phe  Val Gln Gly Glu Arg  Val Ala Gly Gln Pro  Val Val Leu 
    1025                 1030                 1035             


Asp Val  Ala Ala Gly Gly Ile  Asp Ile Ala Ser Arg  Lys Gly Glu 
    1040                 1045                 1050             


Arg Pro  Ala Leu Thr Phe Ile  Thr Pro Leu Ala Ala  Pro Gly Glu 
    1055                 1060                 1065             


Glu Gln  Arg Arg Arg Thr Lys  Thr Gly Lys Ser Glu  Phe Thr Thr 
    1070                 1075                 1080             


Phe Val  Glu Ile Val Gly Lys  Gln Asp Arg Trp Arg  Ile Arg Asp 
    1085                 1090                 1095             


Gly Ala  Ala Asp Thr Thr Ile  Asp Leu Ala Lys Val  Val Ser Gln 
    1100                 1105                 1110             


Leu Val  Asp Ala Asn Gly Val  Leu Lys His Ser Ile  Lys Leu Asp 
    1115                 1120                 1125             


Val Ile  Gly Gly Asp Gly Asp  Asp Val Val Leu Ala  Asn Ala Ser 
    1130                 1135                 1140             


Arg Ile  His Tyr Asp Gly Gly  Ala Gly Thr Asn Thr  Val Ser Tyr 
    1145                 1150                 1155             


Ala Ala  Leu Gly Arg Gln Asp  Ser Ile Thr Val Ser  Ala Asp Gly 
    1160                 1165                 1170             


Glu Arg  Phe Asn Val Arg Lys  Gln Leu Asn Asn Ala  Asn Val Tyr 
    1175                 1180                 1185             


Arg Glu  Gly Val Ala Thr Gln  Thr Thr Ala Tyr Gly  Lys Arg Thr 
    1190                 1195                 1200             


Glu Asn  Val Gln Tyr Arg His  Val Glu Leu Ala Arg  Val Gly Gln 
    1205                 1210                 1215             


Leu Val  Glu Val Asp Thr Leu  Glu His Val Gln His  Ile Ile Gly 
    1220                 1225                 1230             


Gly Ala  Gly Asn Asp Ser Ile  Thr Gly Asn Ala His  Asp Asn Phe 
    1235                 1240                 1245             


Leu Ala  Gly Gly Ser Gly Asp  Asp Arg Leu Asp Gly  Gly Ala Gly 
    1250                 1255                 1260             


Asn Asp  Thr Leu Val Gly Gly  Glu Gly Gln Asn Thr  Val Ile Gly 
    1265                 1270                 1275             


Gly Ala  Gly Asp Asp Val Phe  Leu Gln Asp Leu Gly  Val Trp Ser 
    1280                 1285                 1290             


Asn Gln  Leu Asp Gly Gly Ala  Gly Val Asp Thr Val  Lys Tyr Asn 
    1295                 1300                 1305             


Val His  Gln Pro Ser Glu Glu  Arg Leu Glu Arg Met  Gly Asp Thr 
    1310                 1315                 1320             


Gly Ile  His Ala Asp Leu Gln  Lys Gly Thr Val Glu  Lys Trp Pro 
    1325                 1330                 1335             


Ala Leu  Asn Leu Phe Ser Val  Asp His Val Lys Asn  Ile Glu Asn 
    1340                 1345                 1350             


Leu His  Gly Ser Arg Leu Asn  Asp Arg Ile Ala Gly  Asp Asp Gln 
    1355                 1360                 1365             


Asp Asn  Glu Leu Trp Gly His  Asp Gly Asn Asp Thr  Ile Arg Gly 
    1370                 1375                 1380             


Arg Gly  Gly Asp Asp Ile Leu  Arg Gly Gly Leu Gly  Leu Asp Thr 
    1385                 1390                 1395             


Leu Tyr  Gly Glu Asp Gly Asn  Asp Ile Phe Leu Gln  Asp Asp Glu 
    1400                 1405                 1410             


Thr Val  Ser Asp Asp Ile Asp  Gly Gly Ala Gly Leu  Asp Thr Val 
    1415                 1420                 1425             


Asp Tyr  Ser Ala Met Ile His  Pro Gly Arg Ile Val  Ala Pro His 
    1430                 1435                 1440             


Glu Tyr  Gly Phe Gly Ile Glu  Ala Asp Leu Ser Arg  Glu Trp Val 
    1445                 1450                 1455             


Arg Lys  Ala Ser Ala Leu Gly  Val Asp Tyr Tyr Asp  Asn Val Arg 
    1460                 1465                 1470             


Asn Val  Glu Asn Val Ile Gly  Thr Ser Met Lys Asp  Val Leu Ile 
    1475                 1480                 1485             


Gly Asp  Ala Gln Ala Asn Thr  Leu Met Gly Gln Gly  Gly Asp Asp 
    1490                 1495                 1500             


Thr Val  Arg Gly Gly Asp Gly  Asp Asp Leu Leu Phe  Gly Gly Asp 
    1505                 1510                 1515             


Gly Asn  Asp Met Leu Tyr Gly  Asp Ala Gly Asn Asp  Thr Leu Tyr 
    1520                 1525                 1530             


Gly Gly  Leu Gly Asp Asp Thr  Leu Glu Gly Gly Ala  Gly Asn Asp 
    1535                 1540                 1545             


Trp Phe  Gly Gln Thr Gln Ala  Arg Glu His Asp Val  Leu Arg Gly 
    1550                 1555                 1560             


Gly Asp  Gly Val Asp Thr Val  Asp Tyr Ser Gln Thr  Gly Ala His 
    1565                 1570                 1575             


Ala Gly  Ile Ala Ala Gly Arg  Ile Gly Leu Gly Ile  Leu Ala Asp 
    1580                 1585                 1590             


Leu Gly  Ala Gly Arg Val Asp  Lys Leu Gly Glu Ala  Gly Ser Ser 
    1595                 1600                 1605             


Ala Tyr  Asp Thr Val Ser Gly  Ile Glu Asn Val Val  Gly Thr Glu 
    1610                 1615                 1620             


Leu Ala  Asp Arg Ile Thr Gly  Asp Ala Gln Ala Asn  Val Leu Arg 
    1625                 1630                 1635             


Gly Ala  Gly Gly Ala Asp Val  Leu Ala Gly Gly Glu  Gly Asp Asp 
    1640                 1645                 1650             


Val Leu  Leu Gly Gly Asp Gly  Asp Asp Gln Leu Ser  Gly Asp Ala 
    1655                 1660                 1665             


Gly Arg  Asp Arg Leu Tyr Gly  Glu Ala Gly Asp Asp  Trp Phe Phe 
    1670                 1675                 1680             


Gln Asp  Ala Ala Asn Ala Gly  Asn Leu Leu Asp Gly  Gly Asp Gly 
    1685                 1690                 1695             


Arg Asp  Thr Val Asp Phe Ser  Gly Pro Gly Arg Gly  Leu Asp Ala 
    1700                 1705                 1710             


Gly Ala  Lys Gly Val Phe Leu  Ser Leu Gly Lys Gly  Phe Ala Ser 
    1715                 1720                 1725             


Leu Met  Asp Glu Pro Glu Thr  Ser Asn Val Leu Arg  Asn Ile Glu 
    1730                 1735                 1740             


Asn Ala  Val Gly Ser Ala Arg  Asp Asp Val Leu Ile  Gly Asp Ala 
    1745                 1750                 1755             


Gly Ala  Asn Val Leu Asn Gly  Leu Ala Gly Asn Asp  Val Leu Ser 
    1760                 1765                 1770             


Gly Gly  Ala Gly Asp Asp Val  Leu Leu Gly Asp Glu  Gly Ser Asp 
    1775                 1780                 1785             


Leu Leu  Ser Gly Asp Ala Gly  Asn Asp Asp Leu Phe  Gly Gly Gln 
    1790                 1795                 1800             


Gly Asp  Asp Thr Tyr Leu Phe  Gly Val Gly Tyr Gly  His Asp Thr 
    1805                 1810                 1815             


Ile Tyr  Glu Ser Gly Gly Gly  His Asp Thr Ile Arg  Ile Asn Ala 
    1820                 1825                 1830             


Gly Ala  Asp Gln Leu Trp Phe  Ala Arg Gln Gly Asn  Asp Leu Glu 
    1835                 1840                 1845             


Ile Arg  Ile Leu Gly Thr Asp  Asp Ala Leu Thr Val  His Asp Trp 
    1850                 1855                 1860             


Tyr Arg  Asp Ala Asp His Arg  Val Glu Ile Ile His  Ala Ala Asn 
    1865                 1870                 1875             


Gln Ala  Val Asp Gln Ala Gly  Ile Glu Lys Leu Val  Glu Ala Met 
    1880                 1885                 1890             


Ala Gln  Tyr Pro Asp Pro Gly  Ala Ala Ala Ala Ala  Pro Pro Ala 
    1895                 1900                 1905             


Ala Arg  Val Pro Asp Thr Leu  Met Gln Ser Leu Ala  Val Asn Trp 
    1910                 1915                 1920             


Arg 
    


<210>  65
<211>  12105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid comprising SEQ ID NO:63

<400>  65
atcgagatct gtatggctgt gcaggtcgta aatcactgca taattcgtgt cgctcaaggc       60

gcactcccgt tctggataat gttttttgcg ccgacatcat aacggttctg gcaaatattc      120

tgaaatgagc tgttgacaat taatcatcgg ctcgtataat gtgtggaatt gtgagcggat      180

aacaattata attttgttta actttaagaa ggagatatac atatgcagca gtcccatcag      240

gccggttacg caaacgcagc cgatcgtgaa tctggtatcc cggcagcggt tctggatggt      300

attaaggcag ttgccaaaga gaagaacgct accctgatgt tccgtctggt caacccacac      360

tctacttccc tgatcgcgga aggtgtggcg accaaaggcc tgggtgtgca cgccaaaagc      420

agcgactggg gtctgcaggc aggttatatt ccggtgaacc cgaatctgtc taaactgttc      480

ggtcgtgccc cggaggtgat cgcacgtgca gacaacgatg tcaactcttc tctggcgcat      540

ggtcacaccg cggttgatct gaccctgtcc aaagaacgcc tggattacct gcgtcaggcg      600

ggcctggtga cgggcatggc cgacggtgtt gtagcgagca accacgcggg ttatgaacaa      660

tttgagtttc gcgttaaaga gacctctgac ggtcgttacg cggtgcagta ccgccgcaaa      720

ggtggcgatg actttgaagc tgtcaaagtg atcggtaacg ctgctggaat tccgctgacc      780

gcggatatcg acatgtttgc catcatgcct cacctgtcca actttcgcga ttccgcacgc      840

agctctgtga cgtctggtga ttccgtcact gactacctgg ctcgtacccg tcgtgcggcc      900

tctgaagacg aaatcgacgg ccctgcgggc caggctgaac cagatcgtgc tcactacaac      960

atcgtaactt tttgctgtaa gtgcgatagc actctgcgtc tgtgcgtaca gtctactcac     1020

gttgatatcc gcactctgga agatctgctg atgggtaccc tgggtatcgt ctgcccaatc     1080

tgctctcaaa agcctgcttc tggtgttaac catcagcacc tgccggctcg tcgcgctgaa     1140

ccacagcgtc acacgatgct gtgcatgtgt tgcaaatgcg aggctcgcat cgaactggtt     1200

gttgaatcca gcgctgacga cctgcgtgcg tttcagcaac tgttcctgaa cacgctgtct     1260

tttgtttgtc cgtggtgtgc ctcccagcag gagaacgatg aagcggatgg cgtgtcccac     1320

gcgcagctgc cggcacgtcg tgcagaaccg cagcgccaca agattctgtg cgtttgctgt     1380

aaatgtgatg gccgtatcga actgactgtg gaatcctccg cggaagatct gcgtacgctg     1440

cagcagctgt tcctgtctac cctgtctttc gtgtgcccgt ggtgcgccac caatcaaatg     1500

cacggcgaca ccccgaccct gcacgaatac atgctggacc tgcagccgga aaccacggat     1560

ctgtattgtt atgaacagct gaacgatagc agcgaggaaa tgcacggtcc gaaagcaact     1620

ctgcaggaca ttgtgctgca tctggagcca cagaacgaaa tcccggttga tctgctgtgc     1680

cacgagcaac tgagcgattc cgaagaggaa aacgacgaaa ttgatatgca tggtccgcgc     1740

gagaccctgc aagaaatcgt cctgcacctg gaaccgcaaa acgaactgga ccctgtagac     1800

ctgctgtgct acgaacagct gtccgaatct gaagaagaat cccagatgct gactcgtggc     1860

cagctgaaag aatacatcgg ccaacagcgt ggcgaaggct acgttttcta cgagaatcgt     1920

gcttacggcg ttgcgggcaa atccctgttc gacgatggtc tgggcgctgc accgggcgtt     1980

ccgagcggcc gttctaaatt cagcccggac gtactggaaa ctgtgccggc ttccccgggc     2040

ctgcgccgtc cgtccctggg cgcagtcgaa cgtcaggact ccggctacga ttccctggat     2100

ggcgttggct cccgctcctt ctccctgggc gaggtttctg acatggctgc ggtggaagcg     2160

gcagagctgg aaatgacccg tcaagtgctg cacgcgggcg cacgtcagga cgatgctgag     2220

ccgggcgtgt ccggtgcgtc tgcacactgg ggtcaacgtg ccctgcaggg tgctcaagct     2280

gtcgcggcag cgcagcgtct ggtacatgcg atcgcactga tgacccagtt cggtcgcgca     2340

ggttctacca acactcctca ggaagcagct agcctgtctg ctgctgtttt cggtctgggc     2400

gaagcgtctt ctgcggttgc agaaaccgtg agcggtttct tccgtggttc tagccgctgg     2460

gcgggtggtt ttggtgtagc aggtggcgct atggccctgg gtggcggtat cgcggctgct     2520

gtcggcgcag gtatgagcct gaccgacgat gctcctgcgg gccagaaagc cgcagctggc     2580

gctgaaatcg cgctgcagct gactggtggt accgttgaac tggctagctc tatcgcgctg     2640

gctctggcag cggcacgtgg cgtgacttct ggcctgcaag tcgccggtgc ctctgcgggc     2700

gctgctgcgg gcgctctggc agctgcactg tcccccatgg aaatctacgg tctggtacag     2760

cagtctcact acgcagacca gctggataaa ctggcgcagg agtcttctgc atacggttac     2820

gaaggcgacg cactgctggc gcagctgtat cgtgacaaaa ctgctgctga aggtgctgtg     2880

gcaggcgttt ctgcggtact gtctaccgtt ggcgctgcgg tttctattgc ggctgccgca     2940

tccgttgtag gtgcgccggt tgctgtagtt acctctctgc tgactggtgc actgaacggt     3000

atcctgcgtg gtgttcagca gcctattatc gaaaaactgg cgaatgatta tgcccgtaaa     3060

atcgacgaac tgggcggtcc gcaggcttat tttgaaaaaa acctgcaggc gcgccacgaa     3120

cagctggcaa acagcgacgg cctgcgcaaa atgctggcag acctgcaagc tggttggaac     3180

gcgtcttctg tgatcggcgt gcagaccacc gaaattagca aatctgcgct ggaactggct     3240

gcaattactg gcaacgcgga taacctgaaa agcgttgatg tttttgtcga tcgcttcgtt     3300

cagggcgagc gcgttgctgg tcagccggtt gttctggacg ttgcggcagg cggcatcgac     3360

atcgctagcc gcaagggcga gcgtccggct ctgactttca ttaccccgct ggcagctccg     3420

ggtgaagaac agcgtcgccg taccaagact ggtaaaagcg agttcaccac cttcgtggaa     3480

atcgtaggta aacaggaccg ctggcgtatt cgcgacggtg cggcggacac caccatcgac     3540

ctggcaaaag ttgtttccca actggtagat gctaacggcg tgctgaaaca ttctattaaa     3600

ctggatgtaa tcggcggtga cggcgatgac gttgtactgg cgaacgcgtc tcgtatccac     3660

tatgacggcg gcgcaggtac caacacggtt tcctacgcag cgctgggccg ccaggattcc     3720

atcactgtta gcgccgatgg cgaacgtttc aacgtgcgta aacagctgaa taacgcaaac     3780

gtctatcgtg agggtgtagc tacccagacc accgcgtacg gtaagcgtac cgaaaacgtt     3840

cagtatcgtc acgtggaact ggcacgtgtg ggtcagctgg tagaggtgga tacgctggaa     3900

cacgtgcagc acatcatcgg tggcgccggt aacgattcca ttactggtaa cgctcacgac     3960

aacttcctgg caggtggttc tggtgatgat cgtctggacg gtggtgcggg taacgatacg     4020

ctggtaggcg gcgaaggtca gaacaccgta attggtggtg ccggtgacga cgttttcctg     4080

caggatctgg gcgtttggag caaccagctg gatggcggtg ccggtgttga cacggttaag     4140

tataacgttc accagccgtc tgaagagcgc ctggaacgta tgggtgacac tggtattcat     4200

gccgatctgc agaaaggcac tgttgaaaaa tggcctgcgc tgaacctgtt ctctgtggac     4260

catgttaaga acattgaaaa cctgcatggc tctcgcctga acgaccgtat cgctggtgac     4320

gaccaggata acgaactgtg gggtcatgac ggcaatgata ccattcgcgg tcgtggcggc     4380

gacgatattc tgcgtggcgg tctgggcctg gataccctgt atggtgaaga tggtaacgat     4440

attttcctgc aagacgatga aacggtatct gatgacatcg acggtggtgc aggcctggac     4500

accgtagatt acagcgctat gatccatccg ggtcgtatcg tagctccgca cgagtacggc     4560

ttcggtatcg aggcggacct gtctcgtgaa tgggttcgta aagcgtccgc gctgggtgtg     4620

gactactacg ataacgttcg taacgtggaa aacgtgatcg gtacctccat gaaagacgtg     4680

ctgattggcg acgcacaggc caacactctg atgggccagg gcggtgatga cacggttcgc     4740

ggcggcgacg gtgatgacct gctgttcggt ggtgacggca acgacatgct gtacggcgac     4800

gcgggcaacg acaccctgta cggcggtctg ggtgacgaca ctctggaagg tggtgcaggt     4860

aacgactggt tcggccaaac ccaggcacgc gaacacgacg tgctgcgtgg tggcgacggc     4920

gtagacaccg tggattactc ccaaactggc gctcacgcgg gtatcgcggc cggtcgtatc     4980

ggtctgggca ttctggccga tctgggtgcc ggccgtgtcg acaaactggg tgaggctggc     5040

tctagcgcct atgatactgt ttccggcatc gaaaacgtgg taggcactga actggcagat     5100

cgtatcacgg gtgacgcgca agcgaacgtt ctgcgtggtg ctggcggtgc agacgtgctg     5160

gcgggtggtg aaggcgacga cgtactgctg ggcggtgacg gtgacgatca gctgagcggt     5220

gatgcgggtc gtgaccgtct gtacggtgaa gcaggtgacg attggttctt ccaggacgct     5280

gctaacgctg gcaacctgct ggacggcggc gatggccgtg acactgttga cttcagcggt     5340

ccgggtcgcg gtctggacgc aggcgcgaaa ggcgttttcc tgagcctggg taagggtttc     5400

gcatctctga tggacgaacc agaaaccagc aatgtcctgc gtaacatcga aaacgctgtc     5460

ggttccgcac gcgatgatgt tctgattggc gatgctggtg ccaatgttct gaacggtctg     5520

gcgggtaatg atgtactgtc tggtggcgct ggtgatgatg tcctgctggg tgatgagggc     5580

agcgatctgc tgtccggcga tgccggcaac gacgatctgt tcggtggcca aggtgatgat     5640

acttacctgt tcggcgttgg ctatggtcat gacaccatct atgagtctgg tggcggccac     5700

gatacgattc gtattaatgc aggtgctgac caactgtggt ttgcacgtca gggtaacgat     5760

ctggaaattc gcatcctggg tactgatgac gctctgaccg tacacgactg gtaccgcgat     5820

gcggatcacc gcgtagaaat catccatgcg gctaaccaag ctgtagacca ggctggtatt     5880

gaaaaactgg tagaagcgat ggcacagtat ccggacccag gtgcggctgc tgcagcacct     5940

ccagcggctc gtgtgccgga taccctgatg cagagcctgg ccgtcaattg gcgttaatgg     6000

atccaggcct ctttagaagg agatatacca tgctgccgtc tgcacaggcg ccgtctctgc     6060

tgaatccaac tgatgacttc gctgcgctgg gtaacatcgc gtggctgtgg atgaacagcc     6120

cgatgcaccg tgactggccg gttcacctgc tggcacgtaa cacgctggcg ccgatccagc     6180

tgggtcaata catcctgctg cgttgtaacg acgtgcctgt ggcgtattgc tcctgggcac     6240

tgatggatgc ggataccgag ctgtcctacg ttatggcccc atctagcctg ggcggtaacg     6300

cttggaactg cggcgatcgt ctgtggatca ttgattggat tgctccgttt agccgtgacg     6360

acaaccgtgc tctgcgtcgc gcgctggccg aacgtcatcc ggattctgtt ggccgttccc     6420

tgcgcgtacg tcgcggtggc gacaccgctc gcgtcaaaga ataccgtggt cgtgctctgg     6480

acgcagcggc ggcccgcgct cagctggacc gctaccacgc agaactgatt gccggtctgc     6540

gtgcatccaa tggcggttat gctccgcgtg gccgtggcac cgcataatct agaattcttt     6600

aattaaagat ccggctgcta acaaagcccg aaaggaagct gagttggctg ctgccaccgc     6660

tgagcaatcc aggcatcaaa taaaacgaaa ggctcagtcg aaagactggg cctttcgttt     6720

tatctgttgt ttgtcggtga acgctctcct gagtaggaca aatccgccgg gagcggattt     6780

gaacgttgcg aagcaacggc ccggagggtg gcgggcagga cgcccgccat aaactgccag     6840

gcatcaaatt aagcagaagg ccatcctgac ggatggcctt tttgctagca gcacgccata     6900

gtgactggcg atgctgtcgg aatggacgat atcccgcaag aggcccggca gtaccggcat     6960

aaccaagcct atgcctacag catccagggt gacggtgccg aggatgacga tgagcgcatt     7020

gttagatttc atacacggtg cctgactgcg ttagcaattt aactgtgata aactaccgca     7080

ttaaagctta tcgatgataa gctgtcaaac atgagaattc ttagaaaaac tcatcgagca     7140

tcaaatgaaa ctgcaattta ttcatatcag gattatcaat accatatttt tgaaaaagcc     7200

gtttctgtaa tgaaggagaa aactcaccga ggcagttcca taggatggca agatcctggt     7260

atcggtctgc gattccgact cgtccaacat caatacaacc tattaatttc ccctcgtcaa     7320

aaataaggtt atcaagtgag aaatcaccat gagtgacgac tgaatccggt gagaatggca     7380

aaagcttatg catttctttc cagacttgtt caacaggcca gccattacgc tcgtcatcaa     7440

aatcactcgc atcaaccaaa ccgttattca ttcgtgattg cgcctgagcg agacgaaata     7500

cgcgatcgct gttaaaagga caattacaaa caggaatcga atgcaaccgg cgcaggaaca     7560

ctgccagcgc atcaacaata ttttcacctg aatcaggata ttcttctaat acctggaatg     7620

ctgttttccc ggggatcgca gtggtgagta accatgcatc atcaggagta cggataaaat     7680

gcttgatggt cggaagaggc ataaattccg tcagccagtt tagtctgacc atctcatctg     7740

taacatcatt ggcaacgcta cctttgccat gtttcagaaa caactctggc gcatcgggct     7800

tcccatacaa tcgatagatt gtcgcacctg attgcccgac attatcgcga gcccatttat     7860

acccatataa atcagcatcc atgttggaat ttaatcgcgg cctcgagcaa gacgtttccc     7920

gttgaatatg gctcataaca ccccttgtat tactgtttat gtaagcagac agttttattg     7980

ttcatgacca aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa     8040

aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca     8100

aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt     8160

ccgaaggtaa ctggcttcag cagagcgcag ataccaaata ctgtccttct agtgtagccg     8220

tagttaggcc accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc     8280

ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga     8340

cgatagttac cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc     8400

agcttggagc gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc     8460

gccacgcttc ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca     8520

ggagagcgca cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg     8580

tttcgccacc tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta     8640

tggaaaaacg ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct     8700

cacatgttct ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag     8760

tgagctgata ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa     8820

gcggaagagc gcctgatgcg gtattttctc cttacgcatc tgtgcggtat ttcacaccgc     8880

aatggtgcac tctcagtaca atctgctctg atgccgcata gttaagccag tatacactcc     8940

gctatcgcta cgtgactggg tcatggctgc gccccgacac ccgccaacac ccgctgacgc     9000

gccctgacgg gcttgtctgc tcccggcatc cgcttacaga caagctgtga ccgtctccgg     9060

gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgaggc agctgcggta     9120

aagctcatca gcgtggtcgt gaagcgattc acagatgtct gcctgttcat ccgcgtccag     9180

ctcgttgagt ttctccagaa gcgttaatgt ctggcttctg ataaagcggg ccatgttaag     9240

ggcggttttt tcctgtttgg tcactgatgc ctccgtgtaa gggggatttc tgttcatggg     9300

ggtaatgata ccgatgaaac gagagaggat gctcacgata cgggttactg atgatgaaca     9360

tgcccggtta ctggaacgtt gtgagggtaa acaactggcg gtatggatgc ggcgggacca     9420

gagaaaaatc actcagggtc aatgccagcg cttcgttaat acagatgtag gtgttccaca     9480

gggtagccag cagcatcctg cgatgcagat ccggaacata atggtgcagg gcgctgactt     9540

ccgcgtttcc agactttacg aaacacggaa accgaagacc attcatgttg ttgctcaggt     9600

cgcagacgtt ttgcagcagc agtcgcttca cgttcgctcg cgtatcggtg attcattctg     9660

ctaaccagta aggcaacccc gccagcctag ccgggtcctc aacgacagga gcacgatcat     9720

gcgcacccgt ggccaggacc caacgctgcc cgagatgcgc cgcgtgcggc tgctggagat     9780

ggcggacgcg atggatatgt tctgccaagg gttggtttgc gcattcacag ttctccgcaa     9840

gaattgattg gctccaattc ttggagtggt gaatccgtta gcgaggtgcc gccggcttcc     9900

attcaggtcg aggtggcccg gctccatgca ccgcgacgca acgcggggag gcagacaagg     9960

tatagggcgg cgcctacaat ccatgccaac ccgttccatg tgctcgccga ggcggcataa    10020

atcgccgtga cgatcagcgg tccaatgatc gaagttaggc tggtaagagc cgcgagcgat    10080

ccttgaagct gtccctgatg gtcgtcatct acctgcctgg acagcatggc ctgcaacgcg    10140

ggcatcccga tgccgccgga agcgagaaga atcataatgg ggaaggccat ccagcctcgc    10200

gtcgcgaacg ccagcaagac gtagcccagc gcgtcggccg ccatgccggc gataatggcc    10260

tgcttctcgc cgaaacgttt ggtggcggga ccagtgacga aggcttgagc gagggcgtgc    10320

aagattccga ataccgcaag cgacaggccg atcatcgtcg cgctccagcg aaagcggtcc    10380

tcgccgaaaa tgacccagag cgctgccggc acctgtccta cgagttgcat gataaagaag    10440

acagtcataa gtgcggcgac gatagtcatg ccccgcgccc accggaagga gctgactggg    10500

ttgaaggctc tcaagggcat cggtcgactc atagctgttt cctgtgtgaa attgttatcc    10560

gctcacaatt ccacacaaca tacgagccgg aagcataaag tgtaaagcct ggggtgccta    10620

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa    10680

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat    10740

tgggcgctag cgtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca    10800

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa    10860

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt    10920

atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg    10980

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca    11040

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta    11100

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg    11160

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat    11220

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct    11280

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg    11340

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat    11400

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc    11460

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca    11520

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg    11580

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt    11640

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg    11700

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct    11760

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtcggaat    11820

ttatgcggtg tgaaataccg cacagatgcg taaggagaaa ataccgcatc aggcgctctt    11880

ccgcttcctc gctcactgac tcgctgccac cccgtggcat gcaaggagat ggcgcccaac    11940

agtcccccgg ccacggggcc tgccaccata cccacgccga aacaagcgct catgagcccg    12000

aagtggcgag cccgatcttc cccatcggtg atgtcggcga tataggcgcc agcaaccgca    12060

cctgtggcgc cggtgatgcc ggccacgatg cgtccggcgt agagg                    12105


<210>  66
<211>  5445
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide encoding chimeric CyaA delta 203+ antigen HPV16, HVP18
       and HPV45 full


<220>
<221>  CDS
<222>  (1)..(5445)

<400>  66
atg cag cag tcc cat cag gcc ggt tac gca aac gca gcc gat cgt gaa         48
Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu           
1               5                   10                  15                

tct ggt atc ccg gca gcg gtt ctg gat ggt att aag gca gtt gcc aaa         96
Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys           
            20                  25                  30                    

gag aag aac gct acc ctg atg ttc cgt ctg gtc aac cca cac tct act        144
Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr           
        35                  40                  45                        

tcc ctg atc gcg gaa ggt gtg gcg acc aaa ggc ctg ggt gtg cac gcc        192
Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala           
    50                  55                  60                            

aaa agc agc gac tgg ggt ctg cag gca ggt tat att ccg gtg aac ccg        240
Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro           
65                  70                  75                  80            

aat ctg tct aaa ctg ttc ggt cgt gcc ccg gag gtg atc gca cgt gca        288
Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala           
                85                  90                  95                

gac aac gat gtc aac tct tct ctg gcg cat ggt cac acc gcg gtt gat        336
Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp           
            100                 105                 110                   

ctg acc ctg tcc aaa gaa cgc ctg gat tac ctg cgt cag gcg ggc ctg        384
Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu           
        115                 120                 125                       

gtg acg ggc atg gcc gac ggt gtt gta gcg agc aac cac gcg ggt tat        432
Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr           
    130                 135                 140                           

gaa caa ttt gag ttt cgc gtt aaa gag acc tct gac ggt cgt tac gcg        480
Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala           
145                 150                 155                 160           

gtg cag tac cgc cgc aaa ggt ggc gat gac ttt gaa gct gtc aaa gtg        528
Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val           
                165                 170                 175               

atc ggt aac gct gct gga att gaa gac gaa atc gac ggc cct gcg ggc        576
Ile Gly Asn Ala Ala Gly Ile Glu Asp Glu Ile Asp Gly Pro Ala Gly           
            180                 185                 190                   

cag gct gaa cca gat cgt gct cac tac aac atc gta act ttt tgc tgt        624
Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys           
        195                 200                 205                       

aag tgc gat agc act ctg cgt ctg tgc gta cag tct act cac gtt gat        672
Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp           
    210                 215                 220                           

atc cgc act ctg gaa gat ctg ctg atg ggt acc ctg ggt atc gtc tgc        720
Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys           
225                 230                 235                 240           

cca atc tgc tct caa aag cct gct tct ggt gtt aac cat cag cac ctg        768
Pro Ile Cys Ser Gln Lys Pro Ala Ser Gly Val Asn His Gln His Leu           
                245                 250                 255               

ccg gct cgt cgc gct gaa cca cag cgt cac acg atg ctg tgc atg tgt        816
Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met Cys           
            260                 265                 270                   

tgc aaa tgc gag gct cgc atc gaa ctg gtt gtt gaa tcc agc gct gac        864
Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala Asp           
        275                 280                 285                       

gac ctg cgt gcg ttt cag caa ctg ttc ctg aac acg ctg tct ttt gtt        912
Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe Val           
    290                 295                 300                           

tgt ccg tgg tgt gcc tcc cag cag gag aac gat gaa gcg gat ggc gtg        960
Cys Pro Trp Cys Ala Ser Gln Gln Glu Asn Asp Glu Ala Asp Gly Val           
305                 310                 315                 320           

tcc cac gcg cag ctg ccg gca cgt cgt gca gaa ccg cag cgc cac aag       1008
Ser His Ala Gln Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Lys           
                325                 330                 335               

att ctg tgc gtt tgc tgt aaa tgt gat ggc cgt atc gaa ctg act gtg       1056
Ile Leu Cys Val Cys Cys Lys Cys Asp Gly Arg Ile Glu Leu Thr Val           
            340                 345                 350                   

gaa tcc tcc gcg gaa gat ctg cgt acg ctg cag cag ctg ttc ctg tct       1104
Glu Ser Ser Ala Glu Asp Leu Arg Thr Leu Gln Gln Leu Phe Leu Ser           
        355                 360                 365                       

acc ctg tct ttc gtg tgc ccg tgg tgc gcc acc aat caa atg cac ggc       1152
Thr Leu Ser Phe Val Cys Pro Trp Cys Ala Thr Asn Gln Met His Gly           
    370                 375                 380                           

gac acc ccg acc ctg cac gaa tac atg ctg gac ctg cag ccg gaa acc       1200
Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr           
385                 390                 395                 400           

acg gat ctg tat tgt tat gaa cag ctg aac gat agc agc gag gaa atg       1248
Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser Glu Glu Met           
                405                 410                 415               

cac ggt ccg aaa gca act ctg cag gac att gtg ctg cat ctg gag cca       1296
His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro           
            420                 425                 430                   

cag aac gaa atc ccg gtt gat ctg ctg tgc cac gag caa ctg agc gat       1344
Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser Asp           
        435                 440                 445                       

tcc gaa gag gaa aac gac gaa att gat atg cat ggt ccg cgc gag acc       1392
Ser Glu Glu Glu Asn Asp Glu Ile Asp Met His Gly Pro Arg Glu Thr           
    450                 455                 460                           

ctg caa gaa atc gtc ctg cac ctg gaa ccg caa aac gaa ctg gac cct       1440
Leu Gln Glu Ile Val Leu His Leu Glu Pro Gln Asn Glu Leu Asp Pro           
465                 470                 475                 480           

gta gac ctg ctg tgc tac gaa cag ctg tcc gaa tct gaa gaa ccg ggc       1488
Val Asp Leu Leu Cys Tyr Glu Gln Leu Ser Glu Ser Glu Glu Pro Gly           
                485                 490                 495               

ctg cgc cgt ccg tcc ctg ggc gca gtc gaa cgt cag gac tcc ggc tac       1536
Leu Arg Arg Pro Ser Leu Gly Ala Val Glu Arg Gln Asp Ser Gly Tyr           
            500                 505                 510                   

gat tcc ctg gat ggc gtt ggc tcc cgc tcc ttc tcc ctg ggc gag gtt       1584
Asp Ser Leu Asp Gly Val Gly Ser Arg Ser Phe Ser Leu Gly Glu Val           
        515                 520                 525                       

tct gac atg gct gcg gtg gaa gcg gca gag ctg gaa atg acc cgt caa       1632
Ser Asp Met Ala Ala Val Glu Ala Ala Glu Leu Glu Met Thr Arg Gln           
    530                 535                 540                           

gtg ctg cac gcg ggc gca cgt cag gac gat gct gag ccg ggc gtg tcc       1680
Val Leu His Ala Gly Ala Arg Gln Asp Asp Ala Glu Pro Gly Val Ser           
545                 550                 555                 560           

ggt gcg tct gca cac tgg ggt caa cgt gcc ctg cag ggt gct caa gct       1728
Gly Ala Ser Ala His Trp Gly Gln Arg Ala Leu Gln Gly Ala Gln Ala           
                565                 570                 575               

gtc gcg gca gcg cag cgt ctg gta cat gcg atc gca ctg atg acc cag       1776
Val Ala Ala Ala Gln Arg Leu Val His Ala Ile Ala Leu Met Thr Gln           
            580                 585                 590                   

ttc ggt cgc gca ggt tct acc aac act cct cag gaa gca gct agc ctg       1824
Phe Gly Arg Ala Gly Ser Thr Asn Thr Pro Gln Glu Ala Ala Ser Leu           
        595                 600                 605                       

tct gct gct gtt ttc ggt ctg ggc gaa gcg tct tct gcg gtt gca gaa       1872
Ser Ala Ala Val Phe Gly Leu Gly Glu Ala Ser Ser Ala Val Ala Glu           
    610                 615                 620                           

acc gtg agc ggt ttc ttc cgt ggt tct agc cgc tgg gcg ggt ggt ttt       1920
Thr Val Ser Gly Phe Phe Arg Gly Ser Ser Arg Trp Ala Gly Gly Phe           
625                 630                 635                 640           

ggt gta gca ggt ggc gct atg gcc ctg ggt ggc ggt atc gcg gct gct       1968
Gly Val Ala Gly Gly Ala Met Ala Leu Gly Gly Gly Ile Ala Ala Ala           
                645                 650                 655               

gtc ggc gca ggt atg agc ctg acc gac gat gct cct gcg ggc cag aaa       2016
Val Gly Ala Gly Met Ser Leu Thr Asp Asp Ala Pro Ala Gly Gln Lys           
            660                 665                 670                   

gcc gca gct ggc gct gaa atc gcg ctg cag ctg act ggt ggt acc gtt       2064
Ala Ala Ala Gly Ala Glu Ile Ala Leu Gln Leu Thr Gly Gly Thr Val           
        675                 680                 685                       

gaa ctg gct agc tct atc gcg ctg gct ctg gca gcg gca cgt ggc gtg       2112
Glu Leu Ala Ser Ser Ile Ala Leu Ala Leu Ala Ala Ala Arg Gly Val           
    690                 695                 700                           

act tct ggc ctg caa gtc gcc ggt gcc tct gcg ggc gct gct gcg ggc       2160
Thr Ser Gly Leu Gln Val Ala Gly Ala Ser Ala Gly Ala Ala Ala Gly           
705                 710                 715                 720           

gct ctg gca gct gca ctg tcc ccc atg gaa atc tac ggt ctg gta cag       2208
Ala Leu Ala Ala Ala Leu Ser Pro Met Glu Ile Tyr Gly Leu Val Gln           
                725                 730                 735               

cag tct cac tac gca gac cag ctg gat aaa ctg gcg cag gag tct tct       2256
Gln Ser His Tyr Ala Asp Gln Leu Asp Lys Leu Ala Gln Glu Ser Ser           
            740                 745                 750                   

gca tac ggt tac gaa ggc gac gca ctg ctg gcg cag ctg tat cgt gac       2304
Ala Tyr Gly Tyr Glu Gly Asp Ala Leu Leu Ala Gln Leu Tyr Arg Asp           
        755                 760                 765                       

aaa act gct gct gaa ggt gct gtg gca ggc gtt tct gcg gta ctg tct       2352
Lys Thr Ala Ala Glu Gly Ala Val Ala Gly Val Ser Ala Val Leu Ser           
    770                 775                 780                           

acc gtt ggc gct gcg gtt tct att gcg gct gcc gca tcc gtt gta ggt       2400
Thr Val Gly Ala Ala Val Ser Ile Ala Ala Ala Ala Ser Val Val Gly           
785                 790                 795                 800           

gcg ccg gtt gct gta gtt acc tct ctg ctg act ggt gca ctg aac ggt       2448
Ala Pro Val Ala Val Val Thr Ser Leu Leu Thr Gly Ala Leu Asn Gly           
                805                 810                 815               

atc ctg cgt ggt gtt cag cag cct att atc gaa aaa ctg gcg aat gat       2496
Ile Leu Arg Gly Val Gln Gln Pro Ile Ile Glu Lys Leu Ala Asn Asp           
            820                 825                 830                   

tat gcc cgt aaa atc gac gaa ctg ggc ggt ccg cag gct tat ttt gaa       2544
Tyr Ala Arg Lys Ile Asp Glu Leu Gly Gly Pro Gln Ala Tyr Phe Glu           
        835                 840                 845                       

aaa aac ctg cag gcg cgc cac gaa cag ctg gca aac agc gac ggc ctg       2592
Lys Asn Leu Gln Ala Arg His Glu Gln Leu Ala Asn Ser Asp Gly Leu           
    850                 855                 860                           

cgc aaa atg ctg gca gac ctg caa gct ggt tgg aac gcg tct tct gtg       2640
Arg Lys Met Leu Ala Asp Leu Gln Ala Gly Trp Asn Ala Ser Ser Val           
865                 870                 875                 880           

atc ggc gtg cag acc acc gaa att agc aaa tct gcg ctg gaa ctg gct       2688
Ile Gly Val Gln Thr Thr Glu Ile Ser Lys Ser Ala Leu Glu Leu Ala           
                885                 890                 895               

gca att act ggc aac gcg gat aac ctg aaa agc gtt gat gtt ttt gtc       2736
Ala Ile Thr Gly Asn Ala Asp Asn Leu Lys Ser Val Asp Val Phe Val           
            900                 905                 910                   

gat cgc ttc gtt cag ggc gag cgc gtt gct ggt cag ccg gtt gtt ctg       2784
Asp Arg Phe Val Gln Gly Glu Arg Val Ala Gly Gln Pro Val Val Leu           
        915                 920                 925                       

gac gtt gcg gca ggc ggc atc gac atc gct agc cgc aag ggc gag cgt       2832
Asp Val Ala Ala Gly Gly Ile Asp Ile Ala Ser Arg Lys Gly Glu Arg           
    930                 935                 940                           

ccg gct ctg act ttc att acc ccg ctg gca gct ccg ggt gaa gaa cag       2880
Pro Ala Leu Thr Phe Ile Thr Pro Leu Ala Ala Pro Gly Glu Glu Gln           
945                 950                 955                 960           

cgt cgc cgt acc aag act ggt aaa agc gag ttc acc acc ttc gtg gaa       2928
Arg Arg Arg Thr Lys Thr Gly Lys Ser Glu Phe Thr Thr Phe Val Glu           
                965                 970                 975               

atc gta ggt aaa cag gac cgc tgg cgt att cgc gac ggt gcg gcg gac       2976
Ile Val Gly Lys Gln Asp Arg Trp Arg Ile Arg Asp Gly Ala Ala Asp           
            980                 985                 990                   

acc acc atc gac ctg gca aaa gtt  gtt tcc caa ctg gta  gat gct aac     3024
Thr Thr Ile Asp Leu Ala Lys Val  Val Ser Gln Leu Val  Asp Ala Asn         
        995                 1000                 1005                     

ggc gtg  ctg aaa cat tct att  aaa ctg gat gta atc  ggc ggt gac        3069
Gly Val  Leu Lys His Ser Ile  Lys Leu Asp Val Ile  Gly Gly Asp            
    1010                 1015                 1020                        

ggc gat  gac gtt gta ctg gcg  aac gcg tct cgt atc  cac tat gac        3114
Gly Asp  Asp Val Val Leu Ala  Asn Ala Ser Arg Ile  His Tyr Asp            
    1025                 1030                 1035                        

ggc ggc  gca ggt acc aac acg  gtt tcc tac gca gcg  ctg ggc cgc        3159
Gly Gly  Ala Gly Thr Asn Thr  Val Ser Tyr Ala Ala  Leu Gly Arg            
    1040                 1045                 1050                        

cag gat  tcc atc act gtt agc  gcc gat ggc gaa cgt  ttc aac gtg        3204
Gln Asp  Ser Ile Thr Val Ser  Ala Asp Gly Glu Arg  Phe Asn Val            
    1055                 1060                 1065                        

cgt aaa  cag ctg aat aac gca  aac gtc tat cgt gag  ggt gta gct        3249
Arg Lys  Gln Leu Asn Asn Ala  Asn Val Tyr Arg Glu  Gly Val Ala            
    1070                 1075                 1080                        

acc cag  acc acc gcg tac ggt  aag cgt acc gaa aac  gtt cag tat        3294
Thr Gln  Thr Thr Ala Tyr Gly  Lys Arg Thr Glu Asn  Val Gln Tyr            
    1085                 1090                 1095                        

cgt cac  gtg gaa ctg gca cgt  gtg ggt cag ctg gta  gag gtg gat        3339
Arg His  Val Glu Leu Ala Arg  Val Gly Gln Leu Val  Glu Val Asp            
    1100                 1105                 1110                        

acg ctg  gaa cac gtg cag cac  atc atc ggt ggc gcc  ggt aac gat        3384
Thr Leu  Glu His Val Gln His  Ile Ile Gly Gly Ala  Gly Asn Asp            
    1115                 1120                 1125                        

tcc att  act ggt aac gct cac  gac aac ttc ctg gca  ggt ggt tct        3429
Ser Ile  Thr Gly Asn Ala His  Asp Asn Phe Leu Ala  Gly Gly Ser            
    1130                 1135                 1140                        

ggt gat  gat cgt ctg gac ggt  ggt gcg ggt aac gat  acg ctg gta        3474
Gly Asp  Asp Arg Leu Asp Gly  Gly Ala Gly Asn Asp  Thr Leu Val            
    1145                 1150                 1155                        

ggc ggc  gaa ggt cag aac acc  gta att ggt ggt gcc  ggt gac gac        3519
Gly Gly  Glu Gly Gln Asn Thr  Val Ile Gly Gly Ala  Gly Asp Asp            
    1160                 1165                 1170                        

gtt ttc  ctg cag gat ctg ggc  gtt tgg agc aac cag  ctg gat ggc        3564
Val Phe  Leu Gln Asp Leu Gly  Val Trp Ser Asn Gln  Leu Asp Gly            
    1175                 1180                 1185                        

ggt gcc  ggt gtt gac acg gtt  aag tat aac gtt cac  cag ccg tct        3609
Gly Ala  Gly Val Asp Thr Val  Lys Tyr Asn Val His  Gln Pro Ser            
    1190                 1195                 1200                        

gaa gag  cgc ctg gaa cgt atg  ggt gac act ggt att  cat gcc gat        3654
Glu Glu  Arg Leu Glu Arg Met  Gly Asp Thr Gly Ile  His Ala Asp            
    1205                 1210                 1215                        

ctg cag  aaa ggc act gtt gaa  aaa tgg cct gcg ctg  aac ctg ttc        3699
Leu Gln  Lys Gly Thr Val Glu  Lys Trp Pro Ala Leu  Asn Leu Phe            
    1220                 1225                 1230                        

tct gtg  gac cat gtt aag aac  att gaa aac ctg cat  ggc tct cgc        3744
Ser Val  Asp His Val Lys Asn  Ile Glu Asn Leu His  Gly Ser Arg            
    1235                 1240                 1245                        

ctg aac  gac cgt atc gct ggt  gac gac cag gat aac  gaa ctg tgg        3789
Leu Asn  Asp Arg Ile Ala Gly  Asp Asp Gln Asp Asn  Glu Leu Trp            
    1250                 1255                 1260                        

ggt cat  gac ggc aat gat acc  att cgc ggt cgt ggc  ggc gac gat        3834
Gly His  Asp Gly Asn Asp Thr  Ile Arg Gly Arg Gly  Gly Asp Asp            
    1265                 1270                 1275                        

att ctg  cgt ggc ggt ctg ggc  ctg gat acc ctg tat  ggt gaa gat        3879
Ile Leu  Arg Gly Gly Leu Gly  Leu Asp Thr Leu Tyr  Gly Glu Asp            
    1280                 1285                 1290                        

ggt aac  gat att ttc ctg caa  gac gat gaa acg gta  tct gat gac        3924
Gly Asn  Asp Ile Phe Leu Gln  Asp Asp Glu Thr Val  Ser Asp Asp            
    1295                 1300                 1305                        

atc gac  ggt ggt gca ggc ctg  gac acc gta gat tac  agc gct atg        3969
Ile Asp  Gly Gly Ala Gly Leu  Asp Thr Val Asp Tyr  Ser Ala Met            
    1310                 1315                 1320                        

atc cat  ccg ggt cgt atc gta  gct ccg cac gag tac  ggc ttc ggt        4014
Ile His  Pro Gly Arg Ile Val  Ala Pro His Glu Tyr  Gly Phe Gly            
    1325                 1330                 1335                        

atc gag  gcg gac ctg tct cgt  gaa tgg gtt cgt aaa  gcg tcc gcg        4059
Ile Glu  Ala Asp Leu Ser Arg  Glu Trp Val Arg Lys  Ala Ser Ala            
    1340                 1345                 1350                        

ctg ggt  gtg gac tac tac gat  aac gtt cgt aac gtg  gaa aac gtg        4104
Leu Gly  Val Asp Tyr Tyr Asp  Asn Val Arg Asn Val  Glu Asn Val            
    1355                 1360                 1365                        

atc ggt  acc tcc atg aaa gac  gtg ctg att ggc gac  gca cag gcc        4149
Ile Gly  Thr Ser Met Lys Asp  Val Leu Ile Gly Asp  Ala Gln Ala            
    1370                 1375                 1380                        

aac act  ctg atg ggc cag ggc  ggt gat gac acg gtt  cgc ggc ggc        4194
Asn Thr  Leu Met Gly Gln Gly  Gly Asp Asp Thr Val  Arg Gly Gly            
    1385                 1390                 1395                        

gac ggt  gat gac ctg ctg ttc  ggt ggt gac ggc aac  gac atg ctg        4239
Asp Gly  Asp Asp Leu Leu Phe  Gly Gly Asp Gly Asn  Asp Met Leu            
    1400                 1405                 1410                        

tac ggc  gac gcg ggc aac gac  acc ctg tac ggc ggt  ctg ggt gac        4284
Tyr Gly  Asp Ala Gly Asn Asp  Thr Leu Tyr Gly Gly  Leu Gly Asp            
    1415                 1420                 1425                        

gac act  ctg gaa ggt ggt gca  ggt aac gac tgg ttc  ggc caa acc        4329
Asp Thr  Leu Glu Gly Gly Ala  Gly Asn Asp Trp Phe  Gly Gln Thr            
    1430                 1435                 1440                        

cag gca  cgc gaa cac gac gtg  ctg cgt ggt ggc gac  ggc gta gac        4374
Gln Ala  Arg Glu His Asp Val  Leu Arg Gly Gly Asp  Gly Val Asp            
    1445                 1450                 1455                        

acc gtg  gat tac tcc caa act  ggc gct cac gcg ggt  atc gcg gcc        4419
Thr Val  Asp Tyr Ser Gln Thr  Gly Ala His Ala Gly  Ile Ala Ala            
    1460                 1465                 1470                        

ggt cgt  atc ggt ctg ggc att  ctg gcc gat ctg ggt  gcc ggc cgt        4464
Gly Arg  Ile Gly Leu Gly Ile  Leu Ala Asp Leu Gly  Ala Gly Arg            
    1475                 1480                 1485                        

gtc gac  aaa ctg ggt gag gct  ggc tct agc gcc tat  gat act gtt        4509
Val Asp  Lys Leu Gly Glu Ala  Gly Ser Ser Ala Tyr  Asp Thr Val            
    1490                 1495                 1500                        

tcc ggc  atc gaa aac gtg gta  ggc act gaa ctg gca  gat cgt atc        4554
Ser Gly  Ile Glu Asn Val Val  Gly Thr Glu Leu Ala  Asp Arg Ile            
    1505                 1510                 1515                        

acg ggt  gac gcg caa gcg aac  gtt ctg cgt ggt gct  ggc ggt gca        4599
Thr Gly  Asp Ala Gln Ala Asn  Val Leu Arg Gly Ala  Gly Gly Ala            
    1520                 1525                 1530                        

gac gtg  ctg gcg ggt ggt gaa  ggc gac gac gta ctg  ctg ggc ggt        4644
Asp Val  Leu Ala Gly Gly Glu  Gly Asp Asp Val Leu  Leu Gly Gly            
    1535                 1540                 1545                        

gac ggt  gac gat cag ctg agc  ggt gat gcg ggt cgt  gac cgt ctg        4689
Asp Gly  Asp Asp Gln Leu Ser  Gly Asp Ala Gly Arg  Asp Arg Leu            
    1550                 1555                 1560                        

tac ggt  gaa gca ggt gac gat  tgg ttc ttc cag gac  gct gct aac        4734
Tyr Gly  Glu Ala Gly Asp Asp  Trp Phe Phe Gln Asp  Ala Ala Asn            
    1565                 1570                 1575                        

gct ggc  aac ctg ctg gac ggc  ggc gat ggc cgt gac  act gtt gac        4779
Ala Gly  Asn Leu Leu Asp Gly  Gly Asp Gly Arg Asp  Thr Val Asp            
    1580                 1585                 1590                        

ttc agc  ggt ccg ggt cgc ggt  ctg gac gca ggc gcg  aaa ggc gtt        4824
Phe Ser  Gly Pro Gly Arg Gly  Leu Asp Ala Gly Ala  Lys Gly Val            
    1595                 1600                 1605                        

ttc ctg  agc ctg ggt aag ggt  ttc gca tct ctg atg  gac gaa cca        4869
Phe Leu  Ser Leu Gly Lys Gly  Phe Ala Ser Leu Met  Asp Glu Pro            
    1610                 1615                 1620                        

gaa acc  agc aat gtc ctg cgt  aac atc gaa aac gct  gtc ggt tcc        4914
Glu Thr  Ser Asn Val Leu Arg  Asn Ile Glu Asn Ala  Val Gly Ser            
    1625                 1630                 1635                        

gca cgc  gat gat gtt ctg att  ggc gat gct ggt gcc  aat gtt ctg        4959
Ala Arg  Asp Asp Val Leu Ile  Gly Asp Ala Gly Ala  Asn Val Leu            
    1640                 1645                 1650                        

aac ggt  ctg gcg ggt aat gat  gta ctg tct ggt ggc  gct ggt gat        5004
Asn Gly  Leu Ala Gly Asn Asp  Val Leu Ser Gly Gly  Ala Gly Asp            
    1655                 1660                 1665                        

gat gtc  ctg ctg ggt gat gag  ggc agc gat ctg ctg  tcc ggc gat        5049
Asp Val  Leu Leu Gly Asp Glu  Gly Ser Asp Leu Leu  Ser Gly Asp            
    1670                 1675                 1680                        

gcc ggc  aac gac gat ctg ttc  ggt ggc caa ggt gat  gat act tac        5094
Ala Gly  Asn Asp Asp Leu Phe  Gly Gly Gln Gly Asp  Asp Thr Tyr            
    1685                 1690                 1695                        

ctg ttc  ggc gtt ggc tat ggt  cat gac acc atc tat  gag tct ggt        5139
Leu Phe  Gly Val Gly Tyr Gly  His Asp Thr Ile Tyr  Glu Ser Gly            
    1700                 1705                 1710                        

ggc ggc  cac gat acg att cgt  att aat gca ggt gct  gac caa ctg        5184
Gly Gly  His Asp Thr Ile Arg  Ile Asn Ala Gly Ala  Asp Gln Leu            
    1715                 1720                 1725                        

tgg ttt  gca cgt cag ggt aac  gat ctg gaa att cgc  atc ctg ggt        5229
Trp Phe  Ala Arg Gln Gly Asn  Asp Leu Glu Ile Arg  Ile Leu Gly            
    1730                 1735                 1740                        

act gat  gac gct ctg acc gta  cac gac tgg tac cgc  gat gcg gat        5274
Thr Asp  Asp Ala Leu Thr Val  His Asp Trp Tyr Arg  Asp Ala Asp            
    1745                 1750                 1755                        

cac cgc  gta gaa atc atc cat  gcg gct aac caa gct  gta gac cag        5319
His Arg  Val Glu Ile Ile His  Ala Ala Asn Gln Ala  Val Asp Gln            
    1760                 1765                 1770                        

gct ggt  att gaa aaa ctg gta  gaa gcg atg gca cag  tat ccg gac        5364
Ala Gly  Ile Glu Lys Leu Val  Glu Ala Met Ala Gln  Tyr Pro Asp            
    1775                 1780                 1785                        

cca ggt  gcg gct gct gca gca  cct cca gcg gct cgt  gtg ccg gat        5409
Pro Gly  Ala Ala Ala Ala Ala  Pro Pro Ala Ala Arg  Val Pro Asp            
    1790                 1795                 1800                        

acc ctg  atg cag agc ctg gcc  gtc aat tgg cgt taa                     5445
Thr Leu  Met Gln Ser Leu Ala  Val Asn Trp Arg                             
    1805                 1810                                             


<210>  67
<211>  1814
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  67

Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu 
1               5                   10                  15      


Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys 
            20                  25                  30          


Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr 
        35                  40                  45              


Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala 
    50                  55                  60                  


Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro 
65                  70                  75                  80  


Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala 
                85                  90                  95      


Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp 
            100                 105                 110         


Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu 
        115                 120                 125             


Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr 
    130                 135                 140                 


Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala 
145                 150                 155                 160 


Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val 
                165                 170                 175     


Ile Gly Asn Ala Ala Gly Ile Glu Asp Glu Ile Asp Gly Pro Ala Gly 
            180                 185                 190         


Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys 
        195                 200                 205             


Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp 
    210                 215                 220                 


Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys 
225                 230                 235                 240 


Pro Ile Cys Ser Gln Lys Pro Ala Ser Gly Val Asn His Gln His Leu 
                245                 250                 255     


Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met Cys 
            260                 265                 270         


Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala Asp 
        275                 280                 285             


Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe Val 
    290                 295                 300                 


Cys Pro Trp Cys Ala Ser Gln Gln Glu Asn Asp Glu Ala Asp Gly Val 
305                 310                 315                 320 


Ser His Ala Gln Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Lys 
                325                 330                 335     


Ile Leu Cys Val Cys Cys Lys Cys Asp Gly Arg Ile Glu Leu Thr Val 
            340                 345                 350         


Glu Ser Ser Ala Glu Asp Leu Arg Thr Leu Gln Gln Leu Phe Leu Ser 
        355                 360                 365             


Thr Leu Ser Phe Val Cys Pro Trp Cys Ala Thr Asn Gln Met His Gly 
    370                 375                 380                 


Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr 
385                 390                 395                 400 


Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser Glu Glu Met 
                405                 410                 415     


His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro 
            420                 425                 430         


Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser Asp 
        435                 440                 445             


Ser Glu Glu Glu Asn Asp Glu Ile Asp Met His Gly Pro Arg Glu Thr 
    450                 455                 460                 


Leu Gln Glu Ile Val Leu His Leu Glu Pro Gln Asn Glu Leu Asp Pro 
465                 470                 475                 480 


Val Asp Leu Leu Cys Tyr Glu Gln Leu Ser Glu Ser Glu Glu Pro Gly 
                485                 490                 495     


Leu Arg Arg Pro Ser Leu Gly Ala Val Glu Arg Gln Asp Ser Gly Tyr 
            500                 505                 510         


Asp Ser Leu Asp Gly Val Gly Ser Arg Ser Phe Ser Leu Gly Glu Val 
        515                 520                 525             


Ser Asp Met Ala Ala Val Glu Ala Ala Glu Leu Glu Met Thr Arg Gln 
    530                 535                 540                 


Val Leu His Ala Gly Ala Arg Gln Asp Asp Ala Glu Pro Gly Val Ser 
545                 550                 555                 560 


Gly Ala Ser Ala His Trp Gly Gln Arg Ala Leu Gln Gly Ala Gln Ala 
                565                 570                 575     


Val Ala Ala Ala Gln Arg Leu Val His Ala Ile Ala Leu Met Thr Gln 
            580                 585                 590         


Phe Gly Arg Ala Gly Ser Thr Asn Thr Pro Gln Glu Ala Ala Ser Leu 
        595                 600                 605             


Ser Ala Ala Val Phe Gly Leu Gly Glu Ala Ser Ser Ala Val Ala Glu 
    610                 615                 620                 


Thr Val Ser Gly Phe Phe Arg Gly Ser Ser Arg Trp Ala Gly Gly Phe 
625                 630                 635                 640 


Gly Val Ala Gly Gly Ala Met Ala Leu Gly Gly Gly Ile Ala Ala Ala 
                645                 650                 655     


Val Gly Ala Gly Met Ser Leu Thr Asp Asp Ala Pro Ala Gly Gln Lys 
            660                 665                 670         


Ala Ala Ala Gly Ala Glu Ile Ala Leu Gln Leu Thr Gly Gly Thr Val 
        675                 680                 685             


Glu Leu Ala Ser Ser Ile Ala Leu Ala Leu Ala Ala Ala Arg Gly Val 
    690                 695                 700                 


Thr Ser Gly Leu Gln Val Ala Gly Ala Ser Ala Gly Ala Ala Ala Gly 
705                 710                 715                 720 


Ala Leu Ala Ala Ala Leu Ser Pro Met Glu Ile Tyr Gly Leu Val Gln 
                725                 730                 735     


Gln Ser His Tyr Ala Asp Gln Leu Asp Lys Leu Ala Gln Glu Ser Ser 
            740                 745                 750         


Ala Tyr Gly Tyr Glu Gly Asp Ala Leu Leu Ala Gln Leu Tyr Arg Asp 
        755                 760                 765             


Lys Thr Ala Ala Glu Gly Ala Val Ala Gly Val Ser Ala Val Leu Ser 
    770                 775                 780                 


Thr Val Gly Ala Ala Val Ser Ile Ala Ala Ala Ala Ser Val Val Gly 
785                 790                 795                 800 


Ala Pro Val Ala Val Val Thr Ser Leu Leu Thr Gly Ala Leu Asn Gly 
                805                 810                 815     


Ile Leu Arg Gly Val Gln Gln Pro Ile Ile Glu Lys Leu Ala Asn Asp 
            820                 825                 830         


Tyr Ala Arg Lys Ile Asp Glu Leu Gly Gly Pro Gln Ala Tyr Phe Glu 
        835                 840                 845             


Lys Asn Leu Gln Ala Arg His Glu Gln Leu Ala Asn Ser Asp Gly Leu 
    850                 855                 860                 


Arg Lys Met Leu Ala Asp Leu Gln Ala Gly Trp Asn Ala Ser Ser Val 
865                 870                 875                 880 


Ile Gly Val Gln Thr Thr Glu Ile Ser Lys Ser Ala Leu Glu Leu Ala 
                885                 890                 895     


Ala Ile Thr Gly Asn Ala Asp Asn Leu Lys Ser Val Asp Val Phe Val 
            900                 905                 910         


Asp Arg Phe Val Gln Gly Glu Arg Val Ala Gly Gln Pro Val Val Leu 
        915                 920                 925             


Asp Val Ala Ala Gly Gly Ile Asp Ile Ala Ser Arg Lys Gly Glu Arg 
    930                 935                 940                 


Pro Ala Leu Thr Phe Ile Thr Pro Leu Ala Ala Pro Gly Glu Glu Gln 
945                 950                 955                 960 


Arg Arg Arg Thr Lys Thr Gly Lys Ser Glu Phe Thr Thr Phe Val Glu 
                965                 970                 975     


Ile Val Gly Lys Gln Asp Arg Trp Arg Ile Arg Asp Gly Ala Ala Asp 
            980                 985                 990         


Thr Thr Ile Asp Leu Ala Lys Val  Val Ser Gln Leu Val  Asp Ala Asn 
        995                 1000                 1005             


Gly Val  Leu Lys His Ser Ile  Lys Leu Asp Val Ile  Gly Gly Asp 
    1010                 1015                 1020             


Gly Asp  Asp Val Val Leu Ala  Asn Ala Ser Arg Ile  His Tyr Asp 
    1025                 1030                 1035             


Gly Gly  Ala Gly Thr Asn Thr  Val Ser Tyr Ala Ala  Leu Gly Arg 
    1040                 1045                 1050             


Gln Asp  Ser Ile Thr Val Ser  Ala Asp Gly Glu Arg  Phe Asn Val 
    1055                 1060                 1065             


Arg Lys  Gln Leu Asn Asn Ala  Asn Val Tyr Arg Glu  Gly Val Ala 
    1070                 1075                 1080             


Thr Gln  Thr Thr Ala Tyr Gly  Lys Arg Thr Glu Asn  Val Gln Tyr 
    1085                 1090                 1095             


Arg His  Val Glu Leu Ala Arg  Val Gly Gln Leu Val  Glu Val Asp 
    1100                 1105                 1110             


Thr Leu  Glu His Val Gln His  Ile Ile Gly Gly Ala  Gly Asn Asp 
    1115                 1120                 1125             


Ser Ile  Thr Gly Asn Ala His  Asp Asn Phe Leu Ala  Gly Gly Ser 
    1130                 1135                 1140             


Gly Asp  Asp Arg Leu Asp Gly  Gly Ala Gly Asn Asp  Thr Leu Val 
    1145                 1150                 1155             


Gly Gly  Glu Gly Gln Asn Thr  Val Ile Gly Gly Ala  Gly Asp Asp 
    1160                 1165                 1170             


Val Phe  Leu Gln Asp Leu Gly  Val Trp Ser Asn Gln  Leu Asp Gly 
    1175                 1180                 1185             


Gly Ala  Gly Val Asp Thr Val  Lys Tyr Asn Val His  Gln Pro Ser 
    1190                 1195                 1200             


Glu Glu  Arg Leu Glu Arg Met  Gly Asp Thr Gly Ile  His Ala Asp 
    1205                 1210                 1215             


Leu Gln  Lys Gly Thr Val Glu  Lys Trp Pro Ala Leu  Asn Leu Phe 
    1220                 1225                 1230             


Ser Val  Asp His Val Lys Asn  Ile Glu Asn Leu His  Gly Ser Arg 
    1235                 1240                 1245             


Leu Asn  Asp Arg Ile Ala Gly  Asp Asp Gln Asp Asn  Glu Leu Trp 
    1250                 1255                 1260             


Gly His  Asp Gly Asn Asp Thr  Ile Arg Gly Arg Gly  Gly Asp Asp 
    1265                 1270                 1275             


Ile Leu  Arg Gly Gly Leu Gly  Leu Asp Thr Leu Tyr  Gly Glu Asp 
    1280                 1285                 1290             


Gly Asn  Asp Ile Phe Leu Gln  Asp Asp Glu Thr Val  Ser Asp Asp 
    1295                 1300                 1305             


Ile Asp  Gly Gly Ala Gly Leu  Asp Thr Val Asp Tyr  Ser Ala Met 
    1310                 1315                 1320             


Ile His  Pro Gly Arg Ile Val  Ala Pro His Glu Tyr  Gly Phe Gly 
    1325                 1330                 1335             


Ile Glu  Ala Asp Leu Ser Arg  Glu Trp Val Arg Lys  Ala Ser Ala 
    1340                 1345                 1350             


Leu Gly  Val Asp Tyr Tyr Asp  Asn Val Arg Asn Val  Glu Asn Val 
    1355                 1360                 1365             


Ile Gly  Thr Ser Met Lys Asp  Val Leu Ile Gly Asp  Ala Gln Ala 
    1370                 1375                 1380             


Asn Thr  Leu Met Gly Gln Gly  Gly Asp Asp Thr Val  Arg Gly Gly 
    1385                 1390                 1395             


Asp Gly  Asp Asp Leu Leu Phe  Gly Gly Asp Gly Asn  Asp Met Leu 
    1400                 1405                 1410             


Tyr Gly  Asp Ala Gly Asn Asp  Thr Leu Tyr Gly Gly  Leu Gly Asp 
    1415                 1420                 1425             


Asp Thr  Leu Glu Gly Gly Ala  Gly Asn Asp Trp Phe  Gly Gln Thr 
    1430                 1435                 1440             


Gln Ala  Arg Glu His Asp Val  Leu Arg Gly Gly Asp  Gly Val Asp 
    1445                 1450                 1455             


Thr Val  Asp Tyr Ser Gln Thr  Gly Ala His Ala Gly  Ile Ala Ala 
    1460                 1465                 1470             


Gly Arg  Ile Gly Leu Gly Ile  Leu Ala Asp Leu Gly  Ala Gly Arg 
    1475                 1480                 1485             


Val Asp  Lys Leu Gly Glu Ala  Gly Ser Ser Ala Tyr  Asp Thr Val 
    1490                 1495                 1500             


Ser Gly  Ile Glu Asn Val Val  Gly Thr Glu Leu Ala  Asp Arg Ile 
    1505                 1510                 1515             


Thr Gly  Asp Ala Gln Ala Asn  Val Leu Arg Gly Ala  Gly Gly Ala 
    1520                 1525                 1530             


Asp Val  Leu Ala Gly Gly Glu  Gly Asp Asp Val Leu  Leu Gly Gly 
    1535                 1540                 1545             


Asp Gly  Asp Asp Gln Leu Ser  Gly Asp Ala Gly Arg  Asp Arg Leu 
    1550                 1555                 1560             


Tyr Gly  Glu Ala Gly Asp Asp  Trp Phe Phe Gln Asp  Ala Ala Asn 
    1565                 1570                 1575             


Ala Gly  Asn Leu Leu Asp Gly  Gly Asp Gly Arg Asp  Thr Val Asp 
    1580                 1585                 1590             


Phe Ser  Gly Pro Gly Arg Gly  Leu Asp Ala Gly Ala  Lys Gly Val 
    1595                 1600                 1605             


Phe Leu  Ser Leu Gly Lys Gly  Phe Ala Ser Leu Met  Asp Glu Pro 
    1610                 1615                 1620             


Glu Thr  Ser Asn Val Leu Arg  Asn Ile Glu Asn Ala  Val Gly Ser 
    1625                 1630                 1635             


Ala Arg  Asp Asp Val Leu Ile  Gly Asp Ala Gly Ala  Asn Val Leu 
    1640                 1645                 1650             


Asn Gly  Leu Ala Gly Asn Asp  Val Leu Ser Gly Gly  Ala Gly Asp 
    1655                 1660                 1665             


Asp Val  Leu Leu Gly Asp Glu  Gly Ser Asp Leu Leu  Ser Gly Asp 
    1670                 1675                 1680             


Ala Gly  Asn Asp Asp Leu Phe  Gly Gly Gln Gly Asp  Asp Thr Tyr 
    1685                 1690                 1695             


Leu Phe  Gly Val Gly Tyr Gly  His Asp Thr Ile Tyr  Glu Ser Gly 
    1700                 1705                 1710             


Gly Gly  His Asp Thr Ile Arg  Ile Asn Ala Gly Ala  Asp Gln Leu 
    1715                 1720                 1725             


Trp Phe  Ala Arg Gln Gly Asn  Asp Leu Glu Ile Arg  Ile Leu Gly 
    1730                 1735                 1740             


Thr Asp  Asp Ala Leu Thr Val  His Asp Trp Tyr Arg  Asp Ala Asp 
    1745                 1750                 1755             


His Arg  Val Glu Ile Ile His  Ala Ala Asn Gln Ala  Val Asp Gln 
    1760                 1765                 1770             


Ala Gly  Ile Glu Lys Leu Val  Glu Ala Met Ala Gln  Tyr Pro Asp 
    1775                 1780                 1785             


Pro Gly  Ala Ala Ala Ala Ala  Pro Pro Ala Ala Arg  Val Pro Asp 
    1790                 1795                 1800             


Thr Leu  Met Gln Ser Leu Ala  Val Asn Trp Arg 
    1805                 1810                 


<210>  68
<211>  11776
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid comprising SEQ ID NO:65

<400>  68
atcgagatct gtatggctgt gcaggtcgta aatcactgca taattcgtgt cgctcaaggc       60

gcactcccgt tctggataat gttttttgcg ccgacatcat aacggttctg gcaaatattc      120

tgaaatgagc tgttgacaat taatcatcgg ctcgtataat gtgtggaatt gtgagcggat      180

aacaattata attttgttta actttaagaa ggagatatac atatgcagca gtcccatcag      240

gccggttacg caaacgcagc cgatcgtgaa tctggtatcc cggcagcggt tctggatggt      300

attaaggcag ttgccaaaga gaagaacgct accctgatgt tccgtctggt caacccacac      360

tctacttccc tgatcgcgga aggtgtggcg accaaaggcc tgggtgtgca cgccaaaagc      420

agcgactggg gtctgcaggc aggttatatt ccggtgaacc cgaatctgtc taaactgttc      480

ggtcgtgccc cggaggtgat cgcacgtgca gacaacgatg tcaactcttc tctggcgcat      540

ggtcacaccg cggttgatct gaccctgtcc aaagaacgcc tggattacct gcgtcaggcg      600

ggcctggtga cgggcatggc cgacggtgtt gtagcgagca accacgcggg ttatgaacaa      660

tttgagtttc gcgttaaaga gacctctgac ggtcgttacg cggtgcagta ccgccgcaaa      720

ggtggcgatg actttgaagc tgtcaaagtg atcggtaacg ctgctggaat tgaagacgaa      780

atcgacggcc ctgcgggcca ggctgaacca gatcgtgctc actacaacat cgtaactttt      840

tgctgtaagt gcgatagcac tctgcgtctg tgcgtacagt ctactcacgt tgatatccgc      900

actctggaag atctgctgat gggtaccctg ggtatcgtct gcccaatctg ctctcaaaag      960

cctgcttctg gtgttaacca tcagcacctg ccggctcgtc tgcgctgaac cacagcgtca     1020

cacgatgctg tgcatgtgtt gcaaatgcga ggctcgcatc gaactggttg ttgaatccag     1080

cgctgacgac ctgcgtgcgt ttcagcaact gttcctgaac acgctgtctt ttgtttgtcc     1140

gtggtgtgcc tcccagcagg agaacgatga agcggatggc gtgtcccacg cgcagctgcc     1200

ggcacgtcgt gcagaaccgc agcgccacaa gattctgtgc gtttgctgta aatgtgatgg     1260

ccgtatcgaa ctgactgtgg aatcctccgc ggaagatctg cgtacgctgc agcagctgtt     1320

cctgtctacc ctgtctttcg tgtgcccgtg gtgcgccacc aatcaaatgc acggcgacac     1380

cccgaccctg cacgaataca tgctggacct gcagccggaa accacggatc tgtattgtta     1440

tgaacagctg aacgatagca gcgaggaaat gcacggtccg aaagcaactc tgcaggacat     1500

tgtgctgcat ctggagccac agaacgaaat cccggttgat ctgctgtgcc acgagcaact     1560

gagcgattcc gaagaggaaa acgacgaaat tgatatgcat ggtccgcgcg agaccctgca     1620

agaaatcgtc ctgcacctgg aaccgcaaaa cgaactggac cctgtagacc tgctgtgcta     1680

cgaacagctg tccgaatctg aagaaccggg cctgcgccgt ccgtccctgg gcgcagtcga     1740

acgtcaggac tccggctacg attccctgga tggcgttggc tcccgctcct tctccctggg     1800

cgaggtttct gacatggctg cggtggaagc ggcagagctg gaaatgaccc gtcaagtgct     1860

gcacgcgggc gcacgtcagg acgatgctga gccgggcgtg tccggtgcgt ctgcacactg     1920

gggtcaacgt gccctgcagg gtgctcaagc tgtcgcggca gcgcagcgtc tggtacatgc     1980

gatcgcactg atgacccagt tcggtcgcgc aggttctacc aacactcctc aggaagcagc     2040

tagcctgtct gctgctgttt tcggtctggg cgaagcgtct tctgcggttg cagaaaccgt     2100

gagcggtttc ttccgtggtt ctagccgctg ggcgggtggt tttggtgtag caggtggcgc     2160

tatggccctg ggtggcggta tcgcggctgc tgtcggcgca ggtatgagcc tgaccgacga     2220

tgctcctgcg ggccagaaag ccgcagctgg cgctgaaatc gcgctgcagc tgactggtgg     2280

taccgttgaa ctggctagct ctatcgcgct ggctctggca gcggcacgtg gcgtgacttc     2340

tggcctgcaa gtcgccggtg cctctgcggg cgctgctgcg ggcgctctgg cagctgcact     2400

gtcccccatg gaaatctacg gtctggtaca gcagtctcac tacgcagacc agctggataa     2460

actggcgcag gagtcttctg catacggtta cgaaggcgac gcactgctgg cgcagctgta     2520

tcgtgacaaa actgctgctg aaggtgctgt ggcaggcgtt tctgcggtac tgtctaccgt     2580

tggcgctgcg gtttctattg cggctgccgc atccgttgta ggtgcgccgg ttgctgtagt     2640

tacctctctg ctgactggtg cactgaacgg tatcctgcgt ggtgttcagc agcctattat     2700

cgaaaaactg gcgaatgatt atgcccgtaa aatcgacgaa ctgggcggtc cgcaggctta     2760

ttttgaaaaa aacctgcagg cgcgccacga acagctggca aacagcgacg gcctgcgcaa     2820

aatgctggca gacctgcaag ctggttggaa cgcgtcttct gtgatcggcg tgcagaccac     2880

cgaaattagc aaatctgcgc tggaactggc tgcaattact ggcaacgcgg ataacctgaa     2940

aagcgttgat gtttttgtcg atcgcttcgt tcagggcgag cgcgttgctg gtcagccggt     3000

tgttctggac gttgcggcag gcggcatcga catcgctagc cgcaagggcg agcgtccggc     3060

tctgactttc attaccccgc tggcagctcc gggtgaagaa cagcgtcgcc gtaccaagac     3120

tggtaaaagc gagttcacca ccttcgtgga aatcgtaggt aaacaggacc gctggcgtat     3180

tcgcgacggt gcggcggaca ccaccatcga cctggcaaaa gttgtttccc aactggtaga     3240

tgctaacggc gtgctgaaac attctattaa actggatgta atcggcggtg acggcgatga     3300

cgttgtactg gcgaacgcgt ctcgtatcca ctatgacggc ggcgcaggta ccaacacggt     3360

ttcctacgca gcgctgggcc gccaggattc catcactgtt agcgccgatg gcgaacgttt     3420

caacgtgcgt aaacagctga ataacgcaaa cgtctatcgt gagggtgtag ctacccagac     3480

caccgcgtac ggtaagcgta ccgaaaacgt tcagtatcgt cacgtggaac tggcacgtgt     3540

gggtcagctg gtagaggtgg atacgctgga acacgtgcag cacatcatcg gtggcgccgg     3600

taacgattcc attactggta acgctcacga caacttcctg gcaggtggtt ctggtgatga     3660

tcgtctggac ggtggtgcgg gtaacgatac gctggtaggc ggcgaaggtc agaacaccgt     3720

aattggtggt gccggtgacg acgttttcct gcaggatctg ggcgtttgga gcaaccagct     3780

ggatggcggt gccggtgttg acacggttaa gtataacgtt caccagccgt ctgaagagcg     3840

cctggaacgt atgggtgaca ctggtattca tgccgatctg cagaaaggca ctgttgaaaa     3900

atggcctgcg ctgaacctgt tctctgtgga ccatgttaag aacattgaaa acctgcatgg     3960

ctctcgcctg aacgaccgta tcgctggtga cgaccaggat aacgaactgt ggggtcatga     4020

cggcaatgat accattcgcg gtcgtggcgg cgacgatatt ctgcgtggcg gtctgggcct     4080

ggataccctg tatggtgaag atggtaacga tattttcctg caagacgatg aaacggtatc     4140

tgatgacatc gacggtggtg caggcctgga caccgtagat tacagcgcta tgatccatcc     4200

gggtcgtatc gtagctccgc acgagtacgg cttcggtatc gaggcggacc tgtctcgtga     4260

atgggttcgt aaagcgtccg cgctgggtgt ggactactac gataacgttc gtaacgtgga     4320

aaacgtgatc ggtacctcca tgaaagacgt gctgattggc gacgcacagg ccaacactct     4380

gatgggccag ggcggtgatg acacggttcg cggcggcgac ggtgatgacc tgctgttcgg     4440

tggtgacggc aacgacatgc tgtacggcga cgcgggcaac gacaccctgt acggcggtct     4500

gggtgacgac actctggaag gtggtgcagg taacgactgg ttcggccaaa cccaggcacg     4560

cgaacacgac gtgctgcgtg gtggcgacgg cgtagacacc gtggattact cccaaactgg     4620

cgctcacgcg ggtatcgcgg ccggtcgtat cggtctgggc attctggccg atctgggtgc     4680

cggccgtgtc gacaaactgg gtgaggctgg ctctagcgcc tatgatactg tttccggcat     4740

cgaaaacgtg gtaggcactg aactggcaga tcgtatcacg ggtgacgcgc aagcgaacgt     4800

tctgcgtggt gctggcggtg cagacgtgct ggcgggtggt gaaggcgacg acgtactgct     4860

gggcggtgac ggtgacgatc agctgagcgg tgatgcgggt cgtgaccgtc tgtacggtga     4920

agcaggtgac gattggttct tccaggacgc tgctaacgct ggcaacctgc tggacggcgg     4980

cgatggccgt gacactgttg acttcagcgg tccgggtcgc ggtctggacg caggcgcgaa     5040

aggcgttttc ctgagcctgg gtaagggttt cgcatctctg atggacgaac cagaaaccag     5100

caatgtcctg cgtaacatcg aaaacgctgt cggttccgca cgcgatgatg ttctgattgg     5160

cgatgctggt gccaatgttc tgaacggtct ggcgggtaat gatgtactgt ctggtggcgc     5220

tggtgatgat gtcctgctgg gtgatgaggg cagcgatctg ctgtccggcg atgccggcaa     5280

cgacgatctg ttcggtggcc aaggtgatga tacttacctg ttcggcgttg gctatggtca     5340

tgacaccatc tatgagtctg gtggcggcca cgatacgatt cgtattaatg caggtgctga     5400

ccaactgtgg tttgcacgtc agggtaacga tctggaaatt cgcatcctgg gtactgatga     5460

cgctctgacc gtacacgact ggtaccgcga tgcggatcac cgcgtagaaa tcatccatgc     5520

ggctaaccaa gctgtagacc aggctggtat tgaaaaactg gtagaagcga tggcacagta     5580

tccggaccca ggtgcggctg ctgcagcacc tccagcggct cgtgtgccgg ataccctgat     5640

gcagagcctg gccgtcaatt ggcgttaatg gatccaggcc tctttagaag gagatatacc     5700

atgctgccgt ctgcacaggc gccgtctctg ctgaatccaa ctgatgactt cgctgcgctg     5760

ggtaacatcg cgtggctgtg gatgaacagc ccgatgcacc gtgactggcc ggttcacctg     5820

ctggcacgta acacgctggc gccgatccag ctgggtcaat acatcctgct gcgttgtaac     5880

gacgtgcctg tggcgtattg ctcctgggca ctgatggatg cggataccga gctgtcctac     5940

gttatggccc catctagcct gggcggtaac gcttggaact gcggcgatcg tctgtggatc     6000

attgattgga ttgctccgtt tagccgtgac gacaaccgtg ctctgcgtcg cgcgctggcc     6060

gaacgtcatc cggattctgt tggccgttcc ctgcgcgtac gtcgcggtgg cgacaccgct     6120

cgcgtcaaag aataccgtgg tcgtgctctg gacgcagcgg cggcccgcgc tcagctggac     6180

cgctaccacg cagaactgat tgccggtctg cgtgcatcca atggcggtta tgctccgcgt     6240

ggccgtggca ccgcataatc tagaattctt taattaaaga tccggctgct aacaaagccc     6300

gaaaggaagc tgagttggct gctgccaccg ctgagcaatc caggcatcaa ataaaacgaa     6360

aggctcagtc gaaagactgg gcctttcgtt ttatctgttg tttgtcggtg aacgctctcc     6420

tgagtaggac aaatccgccg ggagcggatt tgaacgttgc gaagcaacgg cccggagggt     6480

ggcgggcagg acgcccgcca taaactgcca ggcatcaaat taagcagaag gccatcctga     6540

cggatggcct ttttgctagc agcacgccat agtgactggc gatgctgtcg gaatggacga     6600

tatcccgcaa gaggcccggc agtaccggca taaccaagcc tatgcctaca gcatccaggg     6660

tgacggtgcc gaggatgacg atgagcgcat tgttagattt catacacggt gcctgactgc     6720

gttagcaatt taactgtgat aaactaccgc attaaagctt atcgatgata agctgtcaaa     6780

catgagaatt cttagaaaaa ctcatcgagc atcaaatgaa actgcaattt attcatatca     6840

ggattatcaa taccatattt ttgaaaaagc cgtttctgta atgaaggaga aaactcaccg     6900

aggcagttcc ataggatggc aagatcctgg tatcggtctg cgattccgac tcgtccaaca     6960

tcaatacaac ctattaattt cccctcgtca aaaataaggt tatcaagtga gaaatcacca     7020

tgagtgacga ctgaatccgg tgagaatggc aaaagcttat gcatttcttt ccagacttgt     7080

tcaacaggcc agccattacg ctcgtcatca aaatcactcg catcaaccaa accgttattc     7140

attcgtgatt gcgcctgagc gagacgaaat acgcgatcgc tgttaaaagg acaattacaa     7200

acaggaatcg aatgcaaccg gcgcaggaac actgccagcg catcaacaat attttcacct     7260

gaatcaggat attcttctaa tacctggaat gctgttttcc cggggatcgc agtggtgagt     7320

aaccatgcat catcaggagt acggataaaa tgcttgatgg tcggaagagg cataaattcc     7380

gtcagccagt ttagtctgac catctcatct gtaacatcat tggcaacgct acctttgcca     7440

tgtttcagaa acaactctgg cgcatcgggc ttcccataca atcgatagat tgtcgcacct     7500

gattgcccga cattatcgcg agcccattta tacccatata aatcagcatc catgttggaa     7560

tttaatcgcg gcctcgagca agacgtttcc cgttgaatat ggctcataac accccttgta     7620

ttactgttta tgtaagcaga cagttttatt gttcatgacc aaaatccctt aacgtgagtt     7680

ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt     7740

ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg     7800

tttgccggat caagagctac caactctttt tccgaaggta actggcttca gcagagcgca     7860

gataccaaat actgtccttc tagtgtagcc gtagttaggc caccacttca agaactctgt     7920

agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga     7980

taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc     8040

gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact     8100

gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga     8160

caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg     8220

aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt     8280

tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt     8340

acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt tatcccctga     8400

ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac     8460

gaccgagcgc agcgagtcag tgagcgagga agcggaagag cgcctgatgc ggtattttct     8520

ccttacgcat ctgtgcggta tttcacaccg caatggtgca ctctcagtac aatctgctct     8580

gatgccgcat agttaagcca gtatacactc cgctatcgct acgtgactgg gtcatggctg     8640

cgccccgaca cccgccaaca cccgctgacg cgccctgacg ggcttgtctg ctcccggcat     8700

ccgcttacag acaagctgtg accgtctccg ggagctgcat gtgtcagagg ttttcaccgt     8760

catcaccgaa acgcgcgagg cagctgcggt aaagctcatc agcgtggtcg tgaagcgatt     8820

cacagatgtc tgcctgttca tccgcgtcca gctcgttgag tttctccaga agcgttaatg     8880

tctggcttct gataaagcgg gccatgttaa gggcggtttt ttcctgtttg gtcactgatg     8940

cctccgtgta agggggattt ctgttcatgg gggtaatgat accgatgaaa cgagagagga     9000

tgctcacgat acgggttact gatgatgaac atgcccggtt actggaacgt tgtgagggta     9060

aacaactggc ggtatggatg cggcgggacc agagaaaaat cactcagggt caatgccagc     9120

gcttcgttaa tacagatgta ggtgttccac agggtagcca gcagcatcct gcgatgcaga     9180

tccggaacat aatggtgcag ggcgctgact tccgcgtttc cagactttac gaaacacgga     9240

aaccgaagac cattcatgtt gttgctcagg tcgcagacgt tttgcagcag cagtcgcttc     9300

acgttcgctc gcgtatcggt gattcattct gctaaccagt aaggcaaccc cgccagccta     9360

gccgggtcct caacgacagg agcacgatca tgcgcacccg tggccaggac ccaacgctgc     9420

ccgagatgcg ccgcgtgcgg ctgctggaga tggcggacgc gatggatatg ttctgccaag     9480

ggttggtttg cgcattcaca gttctccgca agaattgatt ggctccaatt cttggagtgg     9540

tgaatccgtt agcgaggtgc cgccggcttc cattcaggtc gaggtggccc ggctccatgc     9600

accgcgacgc aacgcgggga ggcagacaag gtatagggcg gcgcctacaa tccatgccaa     9660

cccgttccat gtgctcgccg aggcggcata aatcgccgtg acgatcagcg gtccaatgat     9720

cgaagttagg ctggtaagag ccgcgagcga tccttgaagc tgtccctgat ggtcgtcatc     9780

tacctgcctg gacagcatgg cctgcaacgc gggcatcccg atgccgccgg aagcgagaag     9840

aatcataatg gggaaggcca tccagcctcg cgtcgcgaac gccagcaaga cgtagcccag     9900

cgcgtcggcc gccatgccgg cgataatggc ctgcttctcg ccgaaacgtt tggtggcggg     9960

accagtgacg aaggcttgag cgagggcgtg caagattccg aataccgcaa gcgacaggcc    10020

gatcatcgtc gcgctccagc gaaagcggtc ctcgccgaaa atgacccaga gcgctgccgg    10080

cacctgtcct acgagttgca tgataaagaa gacagtcata agtgcggcga cgatagtcat    10140

gccccgcgcc caccggaagg agctgactgg gttgaaggct ctcaagggca tcggtcgact    10200

catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac atacgagccg    10260

gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaacttaca ttaattgcgt    10320

tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg    10380

gccaacgcgc ggggagaggc ggtttgcgta ttgggcgcta gcgtggtttt tcttttcacc    10440

agtgagacgg gcaacagctg attgcccttc accgcctggc cctgagagag ttgcagcaag    10500

cggtccacgc tggtttgccc cagcaggcga aaatcctgtt tgatggtggt taacggcggg    10560

atataacatg agctgtcttc ggtatcgtcg tatcccacta ccgagatatc cgcaccaacg    10620

cgcagcccgg actcggtaat ggcgcgcatt gcgcccagcg ccatctgatc gttggcaacc    10680

agcatcgcag tgggaacgat gccctcattc agcatttgca tggtttgttg aaaaccggac    10740

atggcactcc agtcgccttc ccgttccgct atcggctgaa tttgattgcg agtgagatat    10800

ttatgccagc cagccagacg cagacgcgcc gagacagaac ttaatgggcc cgctaacagc    10860

gcgatttgct ggtgacccaa tgcgaccaga tgctccacgc ccagtcgcgt accgtcttca    10920

tgggagaaaa taatactgtt gatgggtgtc tggtcagaga catcaagaaa taacgccgga    10980

acattagtgc aggcagcttc cacagcaatg gcatcctggt catccagcgg atagttaatg    11040

atcagcccac tgacgcgttg cgcgagaaga ttgtgcaccg ccgctttaca ggcttcgacg    11100

ccgcttcgtt ctaccatcga caccaccacg ctggcaccca gttgatcggc gcgagattta    11160

atcgccgcga caatttgcga cggcgcgtgc agggccagac tggaggtggc aacgccaatc    11220

agcaacgact gtttgcccgc cagttgttgt gccacgcggt tgggaatgta attcagctcc    11280

gccatcgccg cttccacttt ttcccgcgtt ttcgcagaaa cgtggctggc ctggttcacc    11340

acgcgggaaa cggtctgata agagacaccg gcatactctg cgacatcgta taacgttact    11400

ggtttcacat tcaccaccct gaattgactc tcttccgggc gctatcatgc cataccgcga    11460

aaggttttgc gccattcgat ggtgtcggaa tttatgcggt gtgaaatacc gcacagatgc    11520

gtaaggagaa aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcca    11580

ccccgtggca tgcaaggaga tggcgcccaa cagtcccccg gccacggggc ctgccaccat    11640

acccacgccg aaacaagcgc tcatgagccc gaagtggcga gcccgatctt ccccatcggt    11700

gatgtcggcg atataggcgc cagcaaccgc acctgtggcg ccggtgatgc cggccacgat    11760

gcgtccggcg tagagg                                                    11776


<210>  69
<211>  5121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding the wild type CyaA protein of 
       Bordetella pertussis, optimized for E. coli expression

<400>  69
atgcagcagt cccatcaggc cggttacgca aacgcagccg atcgtgaatc tggtatcccg       60

gcagcggttc tggatggtat taaggcagtt gccaaagaga agaacgctac cctgatgttc      120

cgtctggtca acccacactc tacttccctg atcgcggaag gtgtggcgac caaaggcctg      180

ggtgtgcacg ccaaaagcag cgactggggt ctgcaggcag gttatattcc ggtgaacccg      240

aatctgtcta aactgttcgg tcgtgccccg gaggtgatcg cacgtgcaga caacgatgtc      300

aactcttctc tggcgcatgg tcacaccgcg gttgatctga ccctgtccaa agaacgcctg      360

gattacctgc gtcaggcggg cctggtgacg ggcatggccg acggtgttgt agcgagcaac      420

cacgcgggtt atgaacaatt tgagtttcgc gttaaagaga cctctgacgg tcgttacgcg      480

gtgcagtacc gccgcaaagg tggcgatgac tttgaagctg tcaaagtgat cggtaacgct      540

gctggaattc cgctgaccgc ggatatcgac atgtttgcca tcatgcctca cctgtccaac      600

tttcgcgatt ccgcacgcag ctctgtgacg tctggtgatt ccgtcactga ctacctggct      660

cgtacccgtc gtgcggcctc tgaagccact ggtggtctgg atcgtgaacg cattgacctg      720

ctgtggaaaa tcgcccgtgc cggtgcgcgc tctgctgttg gtaccgaagc acgccgccaa      780

tttcgttacg acggcgatat gaacatcggt gtgatcacgg attttgaact ggaagttcgc      840

aatgccctga accgtcgtgc acacgcggtc ggcgcgcagg acgttgttca gcacggtacg      900

gagcagaata acccgttccc agaagcggac gaaaagatct ttgttgtgtc tgccaccggt      960

gaatcccaga tgctgactcg tggccagctg aaagaataca tcggccaaca gcgtggcgaa     1020

ggctacgttt tctacgagaa tcgtgcttac ggcgttgcgg gcaaatccct gttcgacgat     1080

ggtctgggcg ctgcaccggg cgttccgagc ggccgttcta aattcagccc ggacgtactg     1140

gaaactgtgc cggcttcccc gggcctgcgc cgtccgtccc tgggcgcagt cgaacgtcag     1200

gactccggct acgattccct ggatggcgtt ggctcccgct ccttctccct gggcgaggtt     1260

tctgacatgg ctgcggtgga agcggcagag ctggaaatga cccgtcaagt gctgcacgcg     1320

ggcgcacgtc aggacgatgc tgagccgggc gtgtccggtg cgtctgcaca ctggggtcaa     1380

cgtgccctgc agggtgctca agctgtcgcg gcagcgcagc gtctggtaca tgcgatcgca     1440

ctgatgaccc agttcggtcg cgcaggttct accaacactc ctcaggaagc agctagcctg     1500

tctgctgctg ttttcggtct gggcgaagcg tcttctgcgg ttgcagaaac cgtgagcggt     1560

ttcttccgtg gttctagccg ctgggcgggt ggttttggtg tagcaggtgg cgctatggcc     1620

ctgggtggcg gtatcgcggc tgctgtcggc gcaggtatga gcctgaccga cgatgctcct     1680

gcgggccaga aagccgcagc tggcgctgaa atcgcgctgc agctgactgg tggtaccgtt     1740

gaactggcta gctctatcgc gctggctctg gcagcggcac gtggcgtgac ttctggcctg     1800

caagtcgccg gtgcctctgc gggcgctgct gcgggcgctc tggcagctgc actgtccccc     1860

atggaaatct acggtctggt acagcagtct cactacgcag accagctgga taaactggcg     1920

caggagtctt ctgcatacgg ttacgaaggc gacgcactgc tggcgcagct gtatcgtgac     1980

aaaactgctg ctgaaggtgc tgtggcaggc gtttctgcgg tactgtctac cgttggcgct     2040

gcggtttcta ttgcggctgc cgcatccgtt gtaggtgcgc cggttgctgt agttacctct     2100

ctgctgactg gtgcactgaa cggtatcctg cgtggtgttc agcagcctat tatcgaaaaa     2160

ctggcgaatg attatgcccg taaaatcgac gaactgggcg gtccgcaggc ttattttgaa     2220

aaaaacctgc aggcgcgcca cgaacagctg gcaaacagcg acggcctgcg caaaatgctg     2280

gcagacctgc aagctggttg gaacgcgtct tctgtgatcg gcgtgcagac caccgaaatt     2340

agcaaatctg cgctggaact ggctgcaatt actggcaacg cggataacct gaaaagcgtt     2400

gatgtttttg tcgatcgctt cgttcagggc gagcgcgttg ctggtcagcc ggttgttctg     2460

gacgttgcgg caggcggcat cgacatcgct agccgcaagg gcgagcgtcc ggctctgact     2520

ttcattaccc cgctggcagc tccgggtgaa gaacagcgtc gccgtaccaa gactggtaaa     2580

agcgagttca ccaccttcgt ggaaatcgta ggtaaacagg accgctggcg tattcgcgac     2640

ggtgcggcgg acaccaccat cgacctggca aaagttgttt cccaactggt agatgctaac     2700

ggcgtgctga aacattctat taaactggat gtaatcggcg gtgacggcga tgacgttgta     2760

ctggcgaacg cgtctcgtat ccactatgac ggcggcgcag gtaccaacac ggtttcctac     2820

gcagcgctgg gccgccagga ttccatcact gttagcgccg atggcgaacg tttcaacgtg     2880

cgtaaacagc tgaataacgc aaacgtctat cgtgagggtg tagctaccca gaccaccgcg     2940

tacggtaagc gtaccgaaaa cgttcagtat cgtcacgtgg aactggcacg tgtgggtcag     3000

ctggtagagg tggatacgct ggaacacgtg cagcacatca tcggtggcgc cggtaacgat     3060

tccattactg gtaacgctca cgacaacttc ctggcaggtg gttctggtga tgatcgtctg     3120

gacggtggtg cgggtaacga tacgctggta ggcggcgaag gtcagaacac cgtaattggt     3180

ggtgccggtg acgacgtttt cctgcaggat ctgggcgttt ggagcaacca gctggatggc     3240

ggtgccggtg ttgacacggt taagtataac gttcaccagc cgtctgaaga gcgcctggaa     3300

cgtatgggtg acactggtat tcatgccgat ctgcagaaag gcactgttga aaaatggcct     3360

gcgctgaacc tgttctctgt ggaccatgtt aagaacattg aaaacctgca tggctctcgc     3420

ctgaacgacc gtatcgctgg tgacgaccag gataacgaac tgtggggtca tgacggcaat     3480

gataccattc gcggtcgtgg cggcgacgat attctgcgtg gcggtctggg cctggatacc     3540

ctgtatggtg aagatggtaa cgatattttc ctgcaagacg atgaaacggt atctgatgac     3600

atcgacggtg gtgcaggcct ggacaccgta gattacagcg ctatgatcca tccgggtcgt     3660

atcgtagctc cgcacgagta cggcttcggt atcgaggcgg acctgtctcg tgaatgggtt     3720

cgtaaagcgt ccgcgctggg tgtggactac tacgataacg ttcgtaacgt ggaaaacgtg     3780

atcggtacct ccatgaaaga cgtgctgatt ggcgacgcac aggccaacac tctgatgggc     3840

cagggcggtg atgacacggt tcgcggcggc gacggtgatg acctgctgtt cggtggtgac     3900

ggcaacgaca tgctgtacgg cgacgcgggc aacgacaccc tgtacggcgg tctgggtgac     3960

gacactctgg aaggtggtgc aggtaacgac tggttcggcc aaacccaggc acgcgaacac     4020

gacgtgctgc gtggtggcga cggcgtagac accgtggatt actcccaaac tggcgctcac     4080

gcgggtatcg cggccggtcg tatcggtctg ggcattctgg ccgatctggg tgccggccgt     4140

gtcgacaaac tgggtgaggc tggctctagc gcctatgata ctgtttccgg catcgaaaac     4200

gtggtaggca ctgaactggc agatcgtatc acgggtgacg cgcaagcgaa cgttctgcgt     4260

ggtgctggcg gtgcagacgt gctggcgggt ggtgaaggcg acgacgtact gctgggcggt     4320

gacggtgacg atcagctgag cggtgatgcg ggtcgtgacc gtctgtacgg tgaagcaggt     4380

gacgattggt tcttccagga cgctgctaac gctggcaacc tgctggacgg cggcgatggc     4440

cgtgacactg ttgacttcag cggtccgggt cgcggtctgg acgcaggcgc gaaaggcgtt     4500

ttcctgagcc tgggtaaggg tttcgcatct ctgatggacg aaccagaaac cagcaatgtc     4560

ctgcgtaaca tcgaaaacgc tgtcggttcc gcacgcgatg atgttctgat tggcgatgct     4620

ggtgccaatg ttctgaacgg tctggcgggt aatgatgtac tgtctggtgg cgctggtgat     4680

gatgtcctgc tgggtgatga gggcagcgat ctgctgtccg gcgatgccgg caacgacgat     4740

ctgttcggtg gccaaggtga tgatacttac ctgttcggcg ttggctatgg tcatgacacc     4800

atctatgagt ctggtggcgg ccacgatacg attcgtatta atgcaggtgc tgaccaactg     4860

tggtttgcac gtcagggtaa cgatctggaa attcgcatcc tgggtactga tgacgctctg     4920

accgtacacg actggtaccg cgatgcggat caccgcgtag aaatcatcca tgcggctaac     4980

caagctgtag accaggctgg tattgaaaaa ctggtagaag cgatggcaca gtatccggac     5040

ccaggtgcgg ctgctgcagc acctccagcg gctcgtgtgc cggataccct gatgcagagc     5100

ctggccgtca attggcgtta a                                               5121


<210>  70
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEP225 complete sequence 85 aa (Hpv31E742-98/1-28)

<400>  70

Ala Gly Gln Ala Lys Pro Asp Thr Ser Asn Tyr Asn Ile Val Thr Phe 
1               5                   10                  15      


Cys Cys Gln Cys Glu Ser Thr Leu Arg Leu Cys Val Gln Ser Thr Gln 
            20                  25                  30          


Val Asp Ile Arg Ile Leu Gln Glu Leu Leu Met Gly Ser Phe Gly Ile 
        35                  40                  45              


Val Cys Pro Asn Cys Ser Thr Arg Leu Met Arg Gly Glu Thr Pro Thr 
    50                  55                  60                  


Leu Gln Asp Tyr Val Leu Asp Leu Gln Pro Glu Ala Thr Asp Leu Tyr 
65                  70                  75                  80  


Cys Tyr Glu Gln Leu 
                85  


<210>  71
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEP226 complete sequence 84 aa (Hpv33E743-97/1-29)

<400>  71

Gly Gln Ala Gln Pro Ala Thr Ala Asp Tyr Tyr Ile Val Thr Cys Cys 
1               5                   10                  15      


His Thr Cys Asn Thr Thr Val Arg Leu Cys Val Asn Ser Thr Ala Ser 
            20                  25                  30          


Asp Leu Arg Thr Ile Gln Gln Leu Leu Met Gly Thr Val Asn Ile Val 
        35                  40                  45              


Cys Pro Ser Cys Ala Gln Leu Met Arg Gly His Lys Pro Thr Leu Lys 
    50                  55                  60                  


Glu Tyr Ile Leu Asp Leu Tyr Pro Glu Pro Thr Asp Leu Tyr Cys Tyr 
65                  70                  75                  80  


Glu Gln Leu Ser 
                


<210>  72
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEP215 complete sequence 95aa (HPV45E7 44-106/1-32)

<400>  72

Gly Val Ser His Ala Gln Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg 
1               5                   10                  15      


His Lys Ile Leu Cys Val Cys Cys Lys Cys Asp Gly Arg Ile Glu Leu 
            20                  25                  30          


Thr Val Glu Ser Ser Ala Glu Asp Leu Arg Thr Leu Gln Gln Leu Phe 
        35                  40                  45              


Leu Ser Thr Leu Ser Phe Val Cys Pro Trp Cys Ala Thr Asn Gln Met 
    50                  55                  60                  


His Gly Pro Arg Glu Thr Leu Gln Glu Ile Val Leu His Leu Glu Pro 
65                  70                  75                  80  


Gln Asn Glu Leu Asp Pro Val Asp Leu Leu Cys Tyr Glu Gln Leu 
                85                  90                  95  


<210>  73
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEP235 complete sequence 84 aa (Hpv52E745-99/1-29 modified to 
       deleted an auto-immune antigen)

<400>  73

Gly Gln Ala Glu Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr Cys 
1               5                   10                  15      


His Ser Cys Asp Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala Thr 
            20                  25                  30          


Asp Leu Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Leu Gln Val Val 
        35                  40                  45              


Cys Pro Gly Cys Ala Arg Leu Met Arg Gly Asp Lys Ala Thr Ile Lys 
    50                  55                  60                  


Asp Tyr Ile Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu His Cys Tyr 
65                  70                  75                  80  


Glu Gln Leu Gly 
                


<210>  74
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEP228 complete sequence 84 aa (HPV58E744-98/1-29)

<400>  74

Gly Gln Ala Gln Pro Ala Thr Ala Asn Tyr Tyr Ile Val Thr Cys Cys 
1               5                   10                  15      


Tyr Thr Cys Asp Thr Thr Val Arg Leu Cys Ile Asn Ser Thr Thr Thr 
            20                  25                  30          


Asp Val Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Cys Thr Ile Val 
        35                  40                  45              


Cys Pro Ser Cys Ala Gln Gln Met Arg Gly Asn Asn Pro Thr Leu Arg 
    50                  55                  60                  


Glu Tyr Ile Leu Asp Leu His Pro Glu Pro Thr Asp Leu Phe Cys Tyr 
65                  70                  75                  80  


Glu Gln Leu Cys 
                


<210>  75
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA SEQUENCE OF PEP225 (Hpv31E742-98/1-28)

       >pep225 complete sequence 255 bp

<400>  75
gcgggtcaag ccaaaccgga tacctccaac tacaacattg tgaccttctg ttgtcaatgc       60

gagagcacgc tgcgtctgtg tgttcaaagc acccaggttg acattcgtat cctgcaagaa      120

ctgctgatgg gctcttttgg catcgtctgc ccaaattgca gcactcgcct gatgcgtggt      180

gaaacgccga ccctgcagga ttatgtgttg gacttgcagc cggaggcaac ggacctgtac      240

tgctatgagc agctg                                                       255


<210>  76
<211>  252
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA SEQUENCE OF PEP226  (Hpv33E743-97/1-29)

       >pep226 complete sequence 252 bp

<400>  76
ggtcaggcgc aaccggccac ggcggactac tatatcgtga cctgttgcca cacctgcaac       60

actaccgttc gcttgtgtgt caatagcacc gcttccgatc tgcgtaccat tcaacaactg      120

ctgatgggta ccgttaacat cgtgtgcccg agctgcgcac agctgatgcg tggccataag      180

ccgacgctga aagagtatat tctggacctg tacccagagc cgacggattt gtactgttat      240

gaacagctga gc                                                          252


<210>  77
<211>  285
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA SEQUENCE OF PEP215 (HPV45E7 44-106/1-32)

       >pep215 complete sequence 285 bp

<400>  77
ggtgtttctc acgcacaact gccagcgcgt cgcgcggaac cgcaacgtca taagatcctg       60

tgtgtgtgct gcaaatgcga cggccgcatt gagctgactg tagaatcctc tgctgaagac      120

ctgcgtacgc tgcagcagct gtttctgagc accctgtctt tcgtctgtcc ttggtgcgcc      180

accaaccaga tgcacggtcc gcgtgagacc ctgcaggaaa tcgtgctgca cctggaaccg      240

cagaatgaac tggacccggt tgatctgctg tgttacgaac agctg                      285


<210>  78
<211>  252
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA SEQUENCE OF PEP235 (Hpv52E745-99/1-29 modified to delete an 
       auto-immune antigen                                              
       >pep235 complete sequence 252 bp

<400>  78
ggccaggcgg agcaggcgac gagcaactac tacattgtca cgtattgcca ttcctgtgat       60

agcactctgc gtctgtgtat ccacagcacg gcaaccgatc tgcgtacctt gcaacaactg      120

ctgatgggca ccctgcaggt ggtttgtccg ggttgcgctc gcctgatgcg tggtgacaag      180

gccaccatta aagattacat cctggacttg caaccggaaa ccaccgacct gcactgctat      240

gagcagctgg gt                                                          252


<210>  79
<211>  252
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA SEQUENCE OF PEP228 (HPV58E744-98/1-29)                       
       >pep228 complete sequence 252 bp

<400>  79
ggccaggcgc agccagcgac ggccaattac tacatcgtta cctgttgcta tacgtgcgat       60

actaccgtcc gtctgtgcat taacagcacc accacggacg tgcgtaccct gcaacagctg      120

ctgatgggta cctgcacgat tgtttgtccg agctgtgcac aacaaatgcg cggtaataac      180

ccgaccttgc gtgagtatat cttggacctg cacccggagc cgaccgatct gttctgttac      240

gaacagctgt gc                                                          252


