                         SEQUENCE LISTING

<110>  INSERM
 
<120>  METHOD DIAGNOSTIC OF SYSTEMIC SCLEROSIS

<130>  BIO11028 LAMBERT

<160>  6     

<170>  PatentIn version 3.3

<210>  1
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Asp Pro Gln Ser Lys Glu Pro Ala Gly Glu Ala Val Ala Leu 
1               5                   10                  15      


Ala Leu Leu Glu Ser Pro Arg Pro Glu Gly Gly Glu Glu Pro Pro Arg 
            20                  25                  30          


Pro Ser Pro Glu Glu Thr Gln Gln Cys Lys Phe Asp Gly Gln Glu Thr 
        35                  40                  45              


Lys Gly Ser Lys Phe Ile Thr Ser Ser Ala Ser Asp Phe Ser Asp Pro 
    50                  55                  60                  


Val Tyr Lys Glu Ile Ala Ile Thr Asn Gly Cys Ile Asn Arg Met Ser 
65                  70                  75                  80  


Lys Glu Glu Leu Arg Ala Lys Leu Ser Glu Phe Lys Leu Glu Thr Arg 
                85                  90                  95      


Gly Val Lys Asp Val Leu Lys Lys Arg Leu Lys Asn Tyr Tyr Lys Lys 
            100                 105                 110         


Gln Lys Leu Met Leu Lys Glu Ser Asn Phe Ala Asp Ser Tyr Tyr Asp 
        115                 120                 125             


Tyr Ile Cys Ile Ile Asp Phe Glu Ala Thr Cys Glu Glu Gly Asn Pro 
    130                 135                 140                 


Pro Glu Phe Val His Glu Ile Ile Glu Phe Pro Val Val Leu Leu Asn 
145                 150                 155                 160 


Thr His Thr Leu Glu Ile Glu Asp Thr Phe Gln Gln Tyr Val Arg Pro 
                165                 170                 175     


Glu Ile Asn Thr Gln Leu Ser Asp Phe Cys Ile Ser Leu Thr Gly Ile 
            180                 185                 190         


Thr Gln Asp Gln Val Asp Arg Ala Asp Thr Phe Pro Gln Val Leu Lys 
        195                 200                 205             


Lys Val Ile Asp Trp Met Lys Leu Lys Glu Leu Gly Thr Lys Tyr Lys 
    210                 215                 220                 


Tyr Ser Leu Leu Thr Asp Gly Ser Trp Asp Met Ser Lys Phe Leu Asn 
225                 230                 235                 240 


Ile Gln Cys Gln Leu Ser Arg Leu Lys Tyr Pro Pro Phe Ala Lys Lys 
                245                 250                 255     


Trp Ile Asn Ile Arg Lys Ser Tyr Gly Asn Phe Tyr Lys Val Pro Arg 
            260                 265                 270         


Ser Gln Thr Lys Leu Thr Ile Met Leu Glu Lys Leu Gly Met Asp Tyr 
        275                 280                 285             


Asp Gly Arg Pro His Cys Gly Leu Asp Asp Ser Lys Asn Ile Ala Arg 
    290                 295                 300                 


Ile Ala Val Arg Met Leu Gln Asp Gly Cys Glu Leu Arg Ile Asn Glu 
305                 310                 315                 320 


Lys Met His Ala Gly Gln Leu Met Ser Val Ser Ser Ser Leu Pro Ile 
                325                 330                 335     


Glu Gly Thr Pro Pro Pro Gln Met Pro His Phe Arg Lys 
            340                 345                 


<210>  2
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Phe Asp Leu Asn Gly Asn Gly Asp Ile Asp Ile Met Ser Leu 
1               5                   10                  15      


Lys Arg Met Leu Glu Lys Leu Gly Val Pro Lys Thr His Leu Glu Leu 
            20                  25                  30          


Lys Lys Leu Ile Gly Glu Val Ser Ser Gly Ser Gly Glu Thr Phe Ser 
        35                  40                  45              


Tyr Pro Asp Phe Leu Arg Met Met Leu Gly Lys Arg Ser Ala Ile Leu 
    50                  55                  60                  


Lys Met Ile Leu Met Tyr Glu Glu Lys Ala Arg Glu Lys Glu Lys Pro 
65                  70                  75                  80  


Thr Gly Pro Pro Ala Lys Lys Ala Ile Ser Glu Leu Pro 
                85                  90              


<210>  3
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu 
            20                  25                  30          


Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg 
        35                  40                  45              


Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln Leu 
    50                  55                  60                  


Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn 
65                  70                  75                  80  


Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys 
                85                  90                  95      


Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr 
            100                 105                 110         


Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr Val Ala Leu Lys 
        115                 120                 125             


Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys 
    130                 135                 140                 


Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 155 


<210>  4
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  4

His Asn Gln Thr Ser Leu Tyr Lys Lys Ala Gly Ser Glu Ile Asp Ile 
1               5                   10                  15      


Ser Cys Val Lys Ile Glu Gln Val Ile Gly Ala Gly Glu Phe Gly Glu 
            20                  25                  30          


Val Cys Ser Gly His Leu Lys Leu Pro Gly Lys Arg Glu Ile Phe Val 
        35                  40                  45              


Ala Ile Lys Thr Leu Lys Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp 
    50                  55                  60                  


Phe Leu Ser Glu Ala Ser Ile Met Gly Gln Phe Asp His Pro Asn Val 
65                  70                  75                  80  


Ile His Leu Glu Gly Val Val Thr Lys Ser Thr Pro Val Met Ile Ile 
                85                  90                  95      


Thr Glu Phe Met Glu Asn Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn 
            100                 105                 110         


Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile 
        115                 120                 125             


Ala Ala Gly Met Lys Tyr Leu Ala Asp Met Asn Tyr Val His Arg Asp 
    130                 135                 140                 


Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu Val Cys Lys Val 
145                 150                 155                 160 


Ser Asp Phe Gly Leu Ser Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro 
                165                 170                 175     


Thr Tyr Thr Ser Ala Leu Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala 
            180                 185                 190         


Pro Glu Ala Ile Gln Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val Trp 
        195                 200                 205             


Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Tyr Gly Glu Arg Pro 
    210                 215                 220                 


Tyr Trp Asp Met Thr Asn Gln Asp Val Ile Asn Ala Ile Glu Gln Asp 
225                 230                 235                 240 


Tyr Arg Leu Pro Pro Pro Met Asp Cys Pro Ser Ala Leu His Gln Leu 
                245                 250                 255     


Met Leu Asp Cys Trp Gln Lys Asp Arg Asn His Arg Pro Lys Phe Gly 
            260                 265                 270         


Gln Ile Val Asn Thr Leu Asp Lys Met Ile Arg Asn Pro Asn 
        275                 280                 285     


<210>  5
<211>  600
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Val Pro Arg 
    210                 215                 220                 


Pro Trp Ser Asn Gln Thr Ser Leu Tyr Lys Lys Ala Gly Phe Glu Gly 
225                 230                 235                 240 


Asp Arg Thr Met His Gly Lys Ser His Arg Arg Lys Arg Thr Arg Ser 
                245                 250                 255     


Val Glu Asp Asp Glu Glu Gly His Leu Ile Cys Gln Ser Gly Asp Val 
            260                 265                 270         


Leu Ser Ala Arg Tyr Glu Ile Val Asp Thr Leu Gly Glu Gly Ala Phe 
        275                 280                 285             


Gly Lys Val Val Glu Cys Ile Asp His Lys Ala Gly Gly Arg His Val 
    290                 295                 300                 


Ala Val Lys Ile Val Lys Asn Val Asp Arg Tyr Cys Glu Ala Ala Arg 
305                 310                 315                 320 


Ser Glu Ile Gln Val Leu Glu His Leu Asn Thr Thr Asp Pro Asn Ser 
                325                 330                 335     


Thr Phe Arg Cys Val Gln Met Leu Glu Trp Phe Glu His His Gly His 
            340                 345                 350         


Ile Cys Ile Val Phe Glu Leu Leu Gly Leu Ser Thr Tyr Asp Phe Ile 
        355                 360                 365             


Lys Glu Asn Gly Phe Leu Pro Phe Arg Leu Asp His Ile Arg Lys Met 
    370                 375                 380                 


Ala Tyr Gln Ile Cys Lys Ser Val Asn Phe Leu His Ser Asn Lys Leu 
385                 390                 395                 400 


Thr His Thr Asp Leu Lys Pro Glu Asn Ile Leu Phe Val Gln Ser Asp 
                405                 410                 415     


Tyr Thr Glu Ala Tyr Asn Pro Lys Ile Lys Arg Asp Glu Arg Thr Leu 
            420                 425                 430         


Ile Asn Pro Asp Ile Lys Val Val Asp Phe Gly Ser Ala Thr Tyr Asp 
        435                 440                 445             


Asp Glu His His Ser Thr Leu Val Ser Thr Arg His Tyr Arg Ala Pro 
    450                 455                 460                 


Glu Val Ile Leu Ala Leu Gly Trp Ser Gln Pro Cys Asp Val Trp Ser 
465                 470                 475                 480 


Ile Gly Cys Ile Leu Ile Glu Tyr Tyr Leu Gly Phe Thr Val Phe Pro 
                485                 490                 495     


Thr His Asp Ser Lys Glu His Leu Ala Met Met Glu Arg Ile Leu Gly 
            500                 505                 510         


Pro Leu Pro Lys His Met Ile Gln Lys Thr Arg Lys Arg Lys Tyr Phe 
        515                 520                 525             


His His Asp Arg Leu Asp Trp Asp Glu His Ser Ser Ala Gly Arg Tyr 
    530                 535                 540                 


Val Ser Arg Arg Cys Lys Pro Leu Lys Glu Phe Met Leu Ser Gln Asp 
545                 550                 555                 560 


Val Glu His Glu Arg Leu Phe Asp Leu Ile Gln Lys Met Leu Glu Tyr 
                565                 570                 575     


Asp Pro Ala Lys Arg Ile Thr Leu Arg Glu Ala Leu Lys His Pro Phe 
            580                 585                 590         


Phe Asp Leu Leu Lys Lys Ser Ile 
        595                 600 


<210>  6
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Ile Arg Asp Asp Ile Ser Trp Pro Pro Ser Ala Val Cys Ser 
1               5                   10                  15      


Val Ser Leu Ile Leu His Leu Pro Gly Arg Phe Gly His Val Ser Val 
            20                  25                  30          


Ala His Leu Leu Leu Asp His Gly Ala Asp Val Asn Ala Gln Asn Arg 
        35                  40                  45              


Leu Gly Ala Ser Val Leu Thr Val Ala Ser Arg Gly Gly His Leu Gly 
    50                  55                  60                  


Val Val Lys Leu Leu Leu Glu Ala Gly Ala Phe Val Asp His His His 
65                  70                  75                  80  


Pro Ser Gly Glu Gln Leu Gly Leu Gly Gly Ser Arg Asp Glu Pro Leu 
                85                  90                  95      


Asp Ile Thr Ala Leu Met Ala Ala Ile Gln His Gly His Glu Ala Val 
            100                 105                 110         


Val Arg Leu Leu Met Glu Trp Gly Ala Asp Pro Asn His Ala Ala Arg 
        115                 120                 125             


Thr Val Gly Trp Ser Pro Leu Met Leu Ala Ala Leu Thr Gly Arg Leu 
    130                 135                 140                 


Gly Val Ala Gln Gln Leu Val Glu Lys Gly Ala Asn Pro Asp His Leu 
145                 150                 155                 160 


Ser Val Leu Glu Lys Thr Ala Phe Glu Val Ala Leu Asp Cys Lys His 
                165                 170                 175     


Arg Asp Leu Val Asp Tyr Leu Asp Pro Leu Thr Thr Val Arg Pro Lys 
            180                 185                 190         


Thr Gly Gln Ala Ala Cys Pro Pro Trp Leu His Arg Gly Pro Gln Ile 
        195                 200                 205             


Val Phe Met Trp Leu Lys Leu Arg Ile Ala Leu Leu Glu Gly His Ala 
    210                 215                 220                 


Glu Leu Arg Val Gln Pro Cys Arg Pro Leu Arg Leu Arg Lys Trp Cys 
225                 230                 235                 240 


Ala 
    


