                         SEQUENCE LISTING

<110>  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 
       (INSERM)
       UNIVERSITE PARIS DESCARTES
 
<120>  CD147 AS RECEPTOR FOR PILUS-MEDIATED ADHESION OF MENINGOCOCCI TO 
       VASCULAR ENDOTHELIA

<130>  BET13P1932

<150>  EP 12305920.6
<151>  2012-07-27

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  1
gcugucuggu ugcgccauuu u                                                 21


<210>  2
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  2
ggucagagcu acacauugau u                                                 21


<210>  3
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  3
gaagucguca gaacacaucu u                                                 21


<210>  4
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  4
guacaagauc acugacucuu u                                                 21


<210>  5
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  5
ggacaaggcc cucaugaacu u                                                 21


<210>  6
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD147 extracellular domain

<400>  6

Thr His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu 
1               5                   10                  15      


Asp Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala 
            20                  25                  30          


Thr Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys 
        35                  40                  45              


Glu Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val Asp Ser Asp 
    50                  55                  60                  


Asp Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly 
65                  70                  75                  80  


Thr Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys 
                85                  90                  95      


Ser Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys 
            100                 105                 110         


Ser Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr 
        115                 120                 125             


Asp Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe 
    130                 135                 140                 


Val Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn 
145                 150                 155                 160 


Met Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys 
                165                 170                 175     


Gly Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His 
            180                 185                 190 


<210>  7
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Ala Gly Phe Val Gln Ala Pro Leu Ser Gln 
            20                  25                  30          


Gln Arg Trp Val Gly Gly Ser Val Glu Leu His Cys Glu Ala Val Gly 
        35                  40                  45              


Ser Pro Val Pro Glu Ile Gln Trp Trp Phe Glu Gly Gln Gly Pro Asn 
    50                  55                  60                  


Asp Thr Cys Ser Gln Leu Trp Asp Gly Ala Arg Leu Asp Arg Val His 
65                  70                  75                  80  


Ile His Ala Thr Tyr His Gln His Ala Ala Ser Thr Ile Ser Ile Asp 
                85                  90                  95      


Thr Leu Val Glu Glu Asp Thr Gly Thr Tyr Glu Cys Arg Ala Ser Asn 
            100                 105                 110         


Asp Pro Asp Arg Asn His Leu Thr Arg Ala Pro Arg Val Lys Trp Val 
        115                 120                 125             


Arg Ala Gln Ala Val Val Leu Val Leu Glu Pro Gly Thr Val Phe Thr 
    130                 135                 140                 


Thr Val Glu Asp Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn 
145                 150                 155                 160 


Asp Ser Ala Thr Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val 
                165                 170                 175     


Val Leu Lys Glu Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val 
            180                 185                 190         


Asp Ser Asp Asp Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu 
        195                 200                 205             


Pro Met Gly Thr Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys 
    210                 215                 220                 


Ala Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu 
225                 230                 235                 240 


Val Cys Lys Ser Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr 
                245                 250                 255     


Lys Ile Thr Asp Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser 
            260                 265                 270         


Arg Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu 
        275                 280                 285             


Asn Leu Asn Met Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr 
    290                 295                 300                 


Ser Ser Lys Gly Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser 
305                 310                 315                 320 


His Leu Ala Ala Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu 
                325                 330                 335     


Val Leu Val Thr Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu 
            340                 345                 350         


Asp Val Leu Asp Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser 
        355                 360                 365             


Gly Gln His Gln Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser 
    370                 375                 380                 


Ser 
385 


<210>  8
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp 
            20                  25                  30          


Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr 
        35                  40                  45              


Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu 
    50                  55                  60                  


Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val Asp Ser Asp Asp 
65                  70                  75                  80  


Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr 
                85                  90                  95      


Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser 
            100                 105                 110         


Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser 
        115                 120                 125             


Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp 
    130                 135                 140                 


Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val 
145                 150                 155                 160 


Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met 
                165                 170                 175     


Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly 
            180                 185                 190         


Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala 
        195                 200                 205             


Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr 
    210                 215                 220                 


Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp 
225                 230                 235                 240 


Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln 
                245                 250                 255     


Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser 
            260                 265                 


<210>  9
<211>  2107
<212>  DNA
<213>  Homo sapiens

<400>  9
gtacatgcga gcgtgtgcgc gcgtgcgcag gcggggcgac cggcgtcccc ggcgctcgcc       60

ccgcccccga gatgacgccg tgcgtgcgcg cgcccggtcc gcgcctccgc cgctttttat      120

agcggccgcg ggcggcggcg gcagcggttg gaggttgtag gaccggcgag gaataggaat      180

catggcggct gcgctgttcg tgctgctggg attcgcgctg ctgggcaccc acggagcctc      240

cggggctgcc ggcttcgtcc aggcgccgct gtcccagcag aggtgggtgg ggggcagtgt      300

ggagctgcac tgcgaggccg tgggcagccc ggtgcccgag atccagtggt ggtttgaagg      360

gcagggtccc aacgacacct gctcccagct ctgggacggc gcccggctgg accgcgtcca      420

catccacgcc acctaccacc agcacgcggc cagcaccatc tccatcgaca cgctcgtgga      480

ggaggacacg ggcacttacg agtgccgggc cagcaacgac ccggatcgca accacctgac      540

ccgggcgccc agggtcaagt gggtccgcgc ccaggcagtc gtgctagtcc tggaacccgg      600

cacagtcttc actaccgtag aagaccttgg ctccaagata ctcctcacct gctccttgaa      660

tgacagcgcc acagaggtca cagggcaccg ctggctgaag gggggcgtgg tgctgaagga      720

ggacgcgctg cccggccaga aaacggagtt caaggtggac tccgacgacc agtggggaga      780

gtactcctgc gtcttcctcc ccgagcccat gggcacggcc aacatccagc tccacgggcc      840

tcccagagtg aaggctgtga agtcgtcaga acacatcaac gagggggaga cggccatgct      900

ggtctgcaag tcagagtccg tgccacctgt cactgactgg gcctggtaca agatcactga      960

ctctgaggac aaggccctca tgaacggctc cgagagcagg ttcttcgtga gttcctcgca     1020

gggccggtca gagctacaca ttgagaacct gaacatggag gccgaccccg gccagtaccg     1080

gtgcaacggc accagctcca agggctccga ccaggccatc atcacgctcc gcgtgcgcag     1140

ccacctggcc gccctctggc ccttcctggg catcgtggct gaggtgctgg tgctggtcac     1200

catcatcttc atctacgaga agcgccggaa gcccgaggac gtcctggatg atgacgacgc     1260

cggctctgca cccctgaaga gcagcgggca gcaccagaat gacaaaggca agaacgtccg     1320

ccagaggaac tcttcctgag gcaggtggcc cgaggacgct ccctgctcca cgtctgcgcc     1380

gccgccggag tccactccca gtgcttgcaa gattccaagt tctcacctct taaagaaaac     1440

ccaccccgta gattcccatc atacacttcc ttctttttta aaaaagttgg gttttctcca     1500

ttcaggattc tgttccttag gtttttttcc ttctgaagtg tttcacgaga gcccgggagc     1560

tgctgccctg cggccccgtc tgtggctttc agcctctggg tctgagtcat ggccgggtgg     1620

gcggcacagc cttctccact ggccggagtc agtgccaggt ccttgccctt tgtggaaagt     1680

cacaggtcac acgaggggcc ccgtgtcctg cctgtctgaa gccaatgctg tctggttgcg     1740

ccatttttgt gcttttatgt ttaattttat gagggccacg ggtctgtgtt cgactcagcc     1800

tcagggacga ctctgacctc ttggccacag aggactcact tgcccacacc gagggcgacc     1860

ccgtcacagc ctcaagtcac tcccaagccc cctccttgtc tgtgcatccg ggggcagctc     1920

tggagggggt ttgctgggga actggcgcca tcgccgggac tccagaaccg cagaagcctc     1980

cccagctcac ccctggagga cggccggctc tctatagcac cagggctcac gtgggaaccc     2040

ccctcccacc caccgccaca ataaagatcg cccccacctc caccctcaaa aaaaaaaaaa     2100

aaaaaaa                                                               2107


<210>  10
<211>  1759
<212>  DNA
<213>  Homo sapiens

<400>  10
gtacatgcga gcgtgtgcgc gcgtgcgcag gcggggcgac cggcgtcccc ggcgctcgcc       60

ccgcccccga gatgacgccg tgcgtgcgcg cgcccggtcc gcgcctccgc cgctttttat      120

agcggccgcg ggcggcggcg gcagcggttg gaggttgtag gaccggcgag gaataggaat      180

catggcggct gcgctgttcg tgctgctggg attcgcgctg ctgggcaccc acggagcctc      240

cggggctgcc ggcacagtct tcactaccgt agaagacctt ggctccaaga tactcctcac      300

ctgctccttg aatgacagcg ccacagaggt cacagggcac cgctggctga aggggggcgt      360

ggtgctgaag gaggacgcgc tgcccggcca gaaaacggag ttcaaggtgg actccgacga      420

ccagtgggga gagtactcct gcgtcttcct ccccgagccc atgggcacgg ccaacatcca      480

gctccacggg cctcccagag tgaaggctgt gaagtcgtca gaacacatca acgaggggga      540

gacggccatg ctggtctgca agtcagagtc cgtgccacct gtcactgact gggcctggta      600

caagatcact gactctgagg acaaggccct catgaacggc tccgagagca ggttcttcgt      660

gagttcctcg cagggccggt cagagctaca cattgagaac ctgaacatgg aggccgaccc      720

cggccagtac cggtgcaacg gcaccagctc caagggctcc gaccaggcca tcatcacgct      780

ccgcgtgcgc agccacctgg ccgccctctg gcccttcctg ggcatcgtgg ctgaggtgct      840

ggtgctggtc accatcatct tcatctacga gaagcgccgg aagcccgagg acgtcctgga      900

tgatgacgac gccggctctg cacccctgaa gagcagcggg cagcaccaga atgacaaagg      960

caagaacgtc cgccagagga actcttcctg aggcaggtgg cccgaggacg ctccctgctc     1020

cacgtctgcg ccgccgccgg agtccactcc cagtgcttgc aagattccaa gttctcacct     1080

cttaaagaaa acccaccccg tagattccca tcatacactt ccttcttttt taaaaaagtt     1140

gggttttctc cattcaggat tctgttcctt aggttttttt ccttctgaag tgtttcacga     1200

gagcccggga gctgctgccc tgcggccccg tctgtggctt tcagcctctg ggtctgagtc     1260

atggccgggt gggcggcaca gccttctcca ctggccggag tcagtgccag gtccttgccc     1320

tttgtggaaa gtcacaggtc acacgagggg ccccgtgtcc tgcctgtctg aagccaatgc     1380

tgtctggttg cgccattttt gtgcttttat gtttaatttt atgagggcca cgggtctgtg     1440

ttcgactcag cctcagggac gactctgacc tcttggccac agaggactca cttgcccaca     1500

ccgagggcga ccccgtcaca gcctcaagtc actcccaagc cccctccttg tctgtgcatc     1560

cgggggcagc tctggagggg gtttgctggg gaactggcgc catcgccggg actccagaac     1620

cgcagaagcc tccccagctc acccctggag gacggccggc tctctatagc accagggctc     1680

acgtgggaac ccccctccca cccaccgcca caataaagat cgcccccacc tccaccctca     1740

aaaaaaaaaa aaaaaaaaa                                                  1759


<210>  11
<211>  168
<212>  PRT
<213>  Neisseria meningitidis

<400>  11

Met Asn Thr Leu Gln Lys Gly Phe Thr Leu Ile Glu Leu Met Ile Val 
1               5                   10                  15      


Ile Ala Ile Val Gly Ile Leu Ala Ala Val Ala Leu Pro Ala Tyr Gln 
            20                  25                  30          


Asp Tyr Thr Ala Arg Ala Gln Val Ser Glu Ala Ile Leu Leu Ala Glu 
        35                  40                  45              


Gly Gln Lys Ser Ala Val Thr Glu Tyr Tyr Leu Asn His Gly Glu Trp 
    50                  55                  60                  


Pro Gly Asp Asn Ser Ser Ala Gly Val Ala Thr Ser Ala Asp Ile Lys 
65                  70                  75                  80  


Gly Lys Tyr Val Gln Ser Val Thr Val Ala Asn Gly Val Ile Thr Ala 
                85                  90                  95      


Gln Met Ala Ser Ser Asn Val Asn Asn Glu Ile Lys Ser Lys Lys Leu 
            100                 105                 110         


Ser Leu Trp Ala Lys Arg Gln Asn Gly Ser Val Lys Trp Phe Cys Gly 
        115                 120                 125             


Gln Pro Val Thr Arg Thr Thr Ala Thr Ala Thr Asp Val Ala Ala Ala 
    130                 135                 140                 


Asn Gly Lys Thr Asp Asp Lys Ile Asn Thr Lys His Leu Pro Ser Thr 
145                 150                 155                 160 


Cys Arg Asp Asp Ser Ser Ala Ser 
                165             


<210>  12
<211>  148
<212>  PRT
<213>  Neisseria meningitidis

<400>  12

Met Lys Ala Ile Gln Lys Gly Phe Thr Leu Ile Glu Leu Met Ile Val 
1               5                   10                  15      


Ile Ala Ile Val Gly Ile Leu Ala Ala Val Ala Leu Pro Ala Tyr Gln 
            20                  25                  30          


Asp Tyr Thr Ala Arg Ala Gln Met Ser Glu Ala Leu Thr Leu Ala Glu 
        35                  40                  45              


Gly Gln Lys Ser Ala Val Ile Glu Tyr Tyr Ser Asp Asn Gly Thr Phe 
    50                  55                  60                  


Pro Asn Ser Asn Thr Ser Ala Gly Ile Ala Ala Ser Asn Glu Ile Lys 
65                  70                  75                  80  


Gly Lys Tyr Val Ala Ser Val Lys Val Glu Gly Asn Ala Ser Val Ala 
                85                  90                  95      


Ser Ile Thr Ala Thr Met Asn Ser Ser Asn Val Asn Lys Asp Ile Lys 
            100                 105                 110         


Gly Lys Thr Leu Val Leu Val Gly Lys Gln Asn Ser Gly Ser Phe Ser 
        115                 120                 125             


Trp Gly Cys Lys Lys Gly Ser Val Asp Glu Lys Phe Leu Pro Ser Thr 
    130                 135                 140                 


Cys Arg Thr Lys 
145             


<210>  13
<211>  129
<212>  PRT
<213>  Neisseria meningitidis

<400>  13

Met Lys Asn Val Gln Lys Gly Phe Thr Leu Leu Glu Leu Met Ile Ala 
1               5                   10                  15      


Val Ala Ile Leu Gly Ile Leu Thr Leu Ile Thr Tyr Pro Ser Tyr Lys 
            20                  25                  30          


Thr Tyr Ile Arg Arg Val Arg Leu Ser Glu Val Arg Thr Thr Leu Leu 
        35                  40                  45              


His Asn Ala Gln Thr Met Glu Arg Tyr Tyr Arg Gln Lys Gly Thr Phe 
    50                  55                  60                  


Lys Thr Tyr Asp Lys Asn Lys Leu Lys Gln Asn Lys Tyr Phe Asn Val 
65                  70                  75                  80  


Thr Leu Ser Lys Val Ser Pro Asp His Phe Thr Leu Gln Ala Asp Pro 
                85                  90                  95      


Asn Pro Thr Thr Asn Asp Gly Glu Thr Cys Val Val Thr Leu Asn Asp 
            100                 105                 110         


Gly Gly Thr Ile Ala Ala Ser Gly Thr Asn Gln Ser Cys Pro Gly Phe 
        115                 120                 125             


Asp 
    


<210>  14
<211>  162
<212>  PRT
<213>  Neisseria meningitidis

<400>  14

Met Met Ser Asn Lys Met Glu Gln Lys Gly Phe Thr Leu Ile Glu Met 
1               5                   10                  15      


Met Ile Val Val Ala Ile Leu Gly Ile Ile Ser Val Ile Ala Ile Pro 
            20                  25                  30          


Ser Tyr Gln Ser Tyr Ile Glu Lys Gly Tyr Gln Ser Gln Leu Tyr Thr 
        35                  40                  45              


Glu Met Val Gly Ile Asn Asn Ile Ser Lys Gln Phe Ile Leu Lys Asn 
    50                  55                  60                  


Pro Leu Asp Asp Asn Gln Thr Ile Lys Ser Lys Leu Glu Arg Phe Val 
65                  70                  75                  80  


Ser Gly Tyr Lys Met Asn Pro Lys Ile Ala Glu Lys Tyr Asn Val Ser 
                85                  90                  95      


Val His Phe Val Asn Lys Glu Lys Pro Arg Ala Tyr Ser Leu Val Gly 
            100                 105                 110         


Val Pro Lys Thr Gly Thr Gly Tyr Thr Leu Ser Val Trp Met Asn Ser 
        115                 120                 125             


Val Gly Asp Gly Tyr Lys Cys Arg Asp Ala Ala Ser Ala Arg Ala His 
    130                 135                 140                 


Leu Glu Thr Leu Ser Ser Asp Val Gly Cys Glu Ala Phe Ser Asn Arg 
145                 150                 155                 160 


Lys Lys 
        


<210>  15
<211>  1025
<212>  PRT
<213>  Neisseria meningitidis

<400>  15

Met Asn Lys Thr Leu Lys Arg Gln Val Phe Arg His Thr Ala Leu Tyr 
1               5                   10                  15      


Ala Ala Ile Leu Met Phe Ser His Thr Gly Gly Gly Gly Ala Gln Ala 
            20                  25                  30          


Gln Thr Ser Lys Tyr Ala Ile Ile Met Asn Glu Arg Asn Gln Leu Glu 
        35                  40                  45              


Val Lys Gln Glu Gly Ser Tyr Ser Thr Leu Arg Glu Lys Asp Arg Glu 
    50                  55                  60                  


Arg Lys Phe Asp Phe Asn Ala Asn Arg Gly Gly Gly Gly Ser Val Phe 
65                  70                  75                  80  


Phe Asp Asn Thr Asp Thr Leu Val Ser Arg Gln Ser Gly Thr Ala Val 
                85                  90                  95      


Phe Gly Thr Ala Thr Tyr Leu Pro Pro Tyr Gly Lys Val Ser Gly Phe 
            100                 105                 110         


Asp Ala Asp Gly Leu Asn Lys Arg Gly Asn Ala Ala Gly Trp Ile Arg 
        115                 120                 125             


Thr Thr Arg Ile Ala Leu Ala Gly Tyr Ser Tyr Lys Gly Val Val Cys 
    130                 135                 140                 


Arg Ser Gly Thr Gly Cys Pro Lys Leu Val Tyr Lys Thr Arg Phe Ser 
145                 150                 155                 160 


Phe Asp Asn Pro Asp Leu Val Lys Asn Ala Gly Arg Leu Asp Arg His 
                165                 170                 175     


Thr Asp Pro Ser Arg Glu Asn Ser Pro Ile Tyr Lys Leu Lys Asp Tyr 
            180                 185                 190         


Pro Trp Leu Gly Val Ser Phe Asn Leu Gly Ala Glu Gly Thr Thr Lys 
        195                 200                 205             


Asp Gly Lys Thr Ile Asn Lys Leu Val Ser Ser Phe Asp Glu Lys Asn 
    210                 215                 220                 


Ser Ser Asn Asn Asn Leu Val Tyr Thr Thr Glu Gly Arg Asp Ile Ser 
225                 230                 235                 240 


Leu Gly Asp Trp Gln Arg Glu Lys Thr Ala Met Ala Tyr Tyr Leu Asn 
                245                 250                 255     


Ala Lys Leu His Leu Leu Asp Lys Lys Gly Ile Lys Asp Ile Thr Asn 
            260                 265                 270         


Lys Thr Val Gln Leu Gly Val Leu Arg Pro Ser Ile Asp Val Arg Leu 
        275                 280                 285             


Gln Arg Asn Thr Gly Leu Thr Gly Leu Leu Asn Phe Trp Ala Ser Trp 
    290                 295                 300                 


Asp Ile Lys Asp Asn Gly Gln Ile Pro Val Lys Leu Gly Leu Pro Glu 
305                 310                 315                 320 


Val Lys Ala Gly Arg Cys Ile Asn Ala Asn Asn Pro Asn Lys Ser Thr 
                325                 330                 335     


Lys Ala Pro Ser Pro Ala Leu Thr Ala Pro Ala Leu Trp Phe Gly Pro 
            340                 345                 350         


Val Gln Asn Gly Lys Met Glu Met Tyr Ser Ala Ser Val Ser Thr Tyr 
        355                 360                 365             


Pro Asp Ser Ser Ser Ser Arg Ile Phe Leu Gln Asn Leu Lys Arg Lys 
    370                 375                 380                 


Asn Asp Pro Asn Lys Pro Gly Arg Tyr Ser Leu Ala Thr Leu Asn Lys 
385                 390                 395                 400 


Ser Asp Ile Glu Ser Arg Glu Pro Thr Phe Thr Gly Arg Gln Thr Val 
                405                 410                 415     


Ile Arg Leu Asp Lys Gly Val His Gln Ile Lys Leu Lys Gly Asn Glu 
            420                 425                 430         


Val Glu Gly Phe Lys Gly Asn Asn Gly Asn Asp Thr Phe Gly Ile Val 
        435                 440                 445             


Ser Glu Gly Ser Phe Met Pro Asp Asp Ser Glu Trp Lys Lys Val Leu 
    450                 455                 460                 


Leu Pro Trp Thr Val Arg Gly Ser Ala Asp Asp Asn Arg Phe Lys Ser 
465                 470                 475                 480 


Ile Asn Gln Glu Ser Ser Lys Tyr Ser Gln Arg Tyr Arg Ile Arg Asp 
                485                 490                 495     


Asn Asn Gly Asn Arg Asn Leu Gly Asp Ile Val Asn Ser Pro Ile Val 
            500                 505                 510         


Ala Val Gly Glu Tyr Leu Ala Thr Ser Ala Asn Asp Gly Met Val His 
        515                 520                 525             


Ile Phe Lys Lys Asn Gly Gly Gly Asp Asp Arg Asn Tyr Ser Leu Lys 
    530                 535                 540                 


Leu Ser Tyr Ile Pro Gly Thr Met Pro Arg Lys Asp Ile Gln Asn Thr 
545                 550                 555                 560 


Glu Ser Thr Leu Ala Lys Glu Leu Arg Thr Phe Ala Glu Lys Gly Tyr 
                565                 570                 575     


Val Gly Asp Arg Tyr Gly Val Asp Gly Gly Phe Val Leu Arg Glu Val 
            580                 585                 590         


Glu Leu Ser Gly Lys Lys His Val Phe Met Phe Gly Ala Met Gly Phe 
        595                 600                 605             


Gly Gly Arg Gly Ala Tyr Ala Leu Asp Leu Thr Lys Ala Asp Ser Asn 
    610                 615                 620                 


Asn Pro Thr Ala Val Ser Leu Phe Asp Val Lys Asn Asp Lys Asn Ser 
625                 630                 635                 640 


Asn Asn Gly Val Gln Leu Gly Tyr Thr Val Gly Thr Pro Gln Ile Gly 
                645                 650                 655     


Lys Thr His Asp Gly Lys Tyr Ala Ala Phe Leu Ala Ser Gly Tyr Ala 
            660                 665                 670         


Thr Lys Glu Ile Thr Ser Asn Asp Asn Lys Thr Ala Leu Tyr Val Tyr 
        675                 680                 685             


Asp Leu Glu Ser Asn Gly Thr Leu Ile Lys Lys Ile Glu Val Pro Gly 
    690                 695                 700                 


Gly Lys Gly Gly Leu Ser Ser Pro Thr Leu Val Asp Lys Asp Leu Asp 
705                 710                 715                 720 


Gly Thr Val Asp Ile Ala Tyr Ala Gly Asp Arg Gly Gly Lys Met Tyr 
                725                 730                 735     


Arg Phe Asp Leu Ser Gly Asn Asn Leu Asn Ser Trp Thr Val Arg Thr 
            740                 745                 750         


Ile Phe Glu Gly Thr Lys Pro Ile Thr Ser Ala Pro Ala Ile Ser Gln 
        755                 760                 765             


Leu Lys Asp Lys Arg Val Val Ile Phe Gly Thr Gly Ser Asp Leu Ser 
    770                 775                 780                 


Glu Asp Asp Val Asp Asn Asn Asp Met Gln Ser Ile Tyr Gly Ile Phe 
785                 790                 795                 800 


Asp Asn Asp Thr Asp Thr Gly Val Ala Lys Asp Gly Gln Gly Asn Gly 
                805                 810                 815     


Leu Leu Glu Gln Val Leu Ser Glu Glu Asn Lys Thr Leu Phe Leu Thr 
            820                 825                 830         


Asp Tyr Lys Arg Ser Asp Gly Ser Gly Ser Lys Gly Trp Val Val Lys 
        835                 840                 845             


Leu Lys Glu Gly Gln Arg Val Thr Val Lys Pro Thr Val Val Leu Arg 
    850                 855                 860                 


Thr Ala Phe Val Thr Ile His Lys Tyr Thr Gly Thr Asp Lys Cys Gly 
865                 870                 875                 880 


Ala Glu Thr Ala Ile Leu Gly Ile Asn Thr Ala Asp Gly Gly Lys Leu 
                885                 890                 895     


Thr Lys Lys Ser Ala Arg Pro Ile Val Pro Ala Ala Asn Thr Ala Val 
            900                 905                 910         


Ala Gln Tyr Ser Gly His Lys Gln Thr Ala Lys Gly Lys Ser Ile Pro 
        915                 920                 925             


Ile Gly Cys Met Trp Lys Asn Asn Glu Thr Val Cys Pro Asn Gly Tyr 
    930                 935                 940                 


Val Tyr Asp Lys Pro Val Asn Val Arg Tyr Leu Asp Glu Lys Lys Thr 
945                 950                 955                 960 


Asp Gly Phe Ser Thr Thr Ala Asp Gly Asp Ala Gly Gly Ser Gly Ile 
                965                 970                 975     


Asp Pro Asp Gly Lys Arg Ala Gly Lys Asn Asn Arg Cys Phe Ser Gln 
            980                 985                 990         


Lys Gly Val Arg Thr Leu Leu Met  Asn Asp Leu Asp Ser  Leu Asp Ile 
        995                 1000                 1005             


Thr Gly  Pro Thr Cys Gly Met  Lys Arg Ile Ser Trp  Arg Glu Val 
    1010                 1015                 1020             


Phe Phe  
    1025 


<210>  16
<211>  149
<212>  PRT
<213>  Neisseria meningitidis

<400>  16

Met Thr Asp Asn Arg Gly Phe Thr Leu Val Glu Leu Ile Ser Val Val 
1               5                   10                  15      


Leu Ile Leu Ser Val Leu Ala Leu Ile Val Tyr Pro Ser Tyr Arg Asn 
            20                  25                  30          


Tyr Val Glu Lys Ala Lys Ile Asn Ala Val Arg Ala Ala Leu Leu Glu 
        35                  40                  45              


Asn Ala His Phe Met Glu Lys Phe Tyr Leu Gln Asn Gly Arg Phe Lys 
    50                  55                  60                  


Gln Thr Ser Thr Lys Trp Pro Ser Leu Pro Ile Lys Glu Ala Glu Gly 
65                  70                  75                  80  


Phe Cys Ile Arg Leu Asn Gly Ile Ala Arg Gly Ala Leu Asp Ser Lys 
                85                  90                  95      


Phe Met Leu Lys Ala Val Ala Ile Asp Lys Asp Lys Asn Pro Phe Ile 
            100                 105                 110         


Ile Lys Met Asn Glu Asn Leu Val Thr Phe Ile Cys Lys Lys Ser Ala 
        115                 120                 125             


Ser Ser Cys Ser Asp Gly Leu Asp Tyr Phe Lys Gly Asn Asp Lys Asp 
    130                 135                 140                 


Cys Lys Leu Phe Lys 
145                 


<210>  17
<211>  280
<212>  PRT
<213>  Neisseria meningitidis

<400>  17

Met Thr Arg Ser Lys Pro Val Asn Arg Thr Ala Phe Cys Cys Leu Ser 
1               5                   10                  15      


Leu Thr Ala Ala Leu Ile Leu Thr Ala Cys Ser Ser Gly Gly Gly Gly 
            20                  25                  30          


Val Ala Ala Asp Ile Gly Ala Val Leu Ala Asp Ala Leu Thr Ala Pro 
        35                  40                  45              


Leu Asp His Lys Asp Lys Ser Leu Gln Ser Leu Thr Leu Asp Gln Ser 
    50                  55                  60                  


Val Arg Lys Asn Glu Lys Leu Lys Leu Ala Ala Gln Gly Ala Glu Lys 
65                  70                  75                  80  


Thr Tyr Gly Asn Gly Asp Ser Leu Asn Thr Gly Lys Leu Lys Asn Asp 
                85                  90                  95      


Lys Val Ser Arg Phe Asp Phe Ile Arg Gln Ile Glu Val Asp Gly Gln 
            100                 105                 110         


Leu Ile Thr Leu Glu Ser Gly Glu Phe Gln Val Tyr Lys Gln Ser His 
        115                 120                 125             


Ser Ala Leu Thr Ala Leu Gln Thr Glu Gln Val Gln Asp Ser Glu His 
    130                 135                 140                 


Ser Gly Lys Met Val Ala Lys Arg Gln Phe Arg Ile Gly Asp Ile Ala 
145                 150                 155                 160 


Gly Glu His Thr Ser Phe Asp Lys Leu Pro Glu Gly Gly Arg Ala Thr 
                165                 170                 175     


Tyr Arg Gly Thr Ala Phe Gly Ser Asp Asp Ala Ser Gly Lys Leu Thr 
            180                 185                 190         


Tyr Thr Ile Asp Phe Ala Ala Lys Gln Gly His Gly Lys Ile Glu His 
        195                 200                 205             


Leu Lys Ser Pro Glu Leu Asn Val Asp Leu Ala Ala Ser Asp Ile Lys 
    210                 215                 220                 


Pro Asp Lys Lys Arg His Ala Val Ile Ser Gly Ser Val Leu Tyr Asn 
225                 230                 235                 240 


Gln Ala Glu Lys Gly Ser Tyr Ser Leu Gly Ile Phe Gly Gly Gln Ala 
                245                 250                 255     


Gln Glu Val Ala Gly Ser Ala Glu Val Glu Thr Ala Asn Gly Ile Arg 
            260                 265                 270         


His Ile Gly Leu Ala Ala Lys Gln 
        275                 280 


<210>  18
<211>  279
<212>  PRT
<213>  Neisseria meningitidis

<400>  18

Met Thr Arg Ser Lys Pro Val Asn Arg Thr Ala Phe Cys Cys Leu Ser 
1               5                   10                  15      


Leu Thr Ala Ala Leu Ile Leu Thr Ala Cys Ser Ser Gly Gly Gly Gly 
            20                  25                  30          


Val Ala Ala Asp Ile Gly Ala Gly Leu Ala Asp Ala Leu Thr Ala Pro 
        35                  40                  45              


Leu Asp His Lys Asp Lys Ser Leu Gln Ser Leu Thr Leu Asp Gln Ser 
    50                  55                  60                  


Val Arg Lys Asn Glu Lys Leu Lys Leu Ala Ala Gln Gly Ala Glu Lys 
65                  70                  75                  80  


Thr Tyr Gly Asn Gly Asp Ser Leu Asn Thr Gly Lys Leu Lys Asn Asp 
                85                  90                  95      


Lys Val Ser Arg Phe Asp Phe Ile Arg Gln Ile Glu Val Asp Gly Gln 
            100                 105                 110         


Leu Ile Thr Leu Glu Ser Gly Glu Phe Gln Ile Tyr Lys Gln Asp His 
        115                 120                 125             


Ser Ala Val Val Ala Leu Gln Ile Glu Lys Ile Asn Asn Pro Asp Lys 
    130                 135                 140                 


Ile Asp Ser Leu Ile Asn Gln Arg Ser Phe Leu Val Ser Gly Leu Gly 
145                 150                 155                 160 


Gly Glu His Thr Ala Phe Asn Gln Leu Pro Gly Gly Lys Ala Glu Tyr 
                165                 170                 175     


His Gly Lys Ala Phe Ser Ser Asp Asp Ala Gly Gly Lys Leu Thr Tyr 
            180                 185                 190         


Thr Ile Asp Phe Ala Ala Lys Gln Gly His Gly Lys Ile Glu His Leu 
        195                 200                 205             


Lys Thr Pro Glu Gln Asn Val Glu Leu Ala Ala Ala Glu Leu Lys Ala 
    210                 215                 220                 


Asp Glu Lys Ser His Ala Val Ile Leu Gly Asp Thr Arg Tyr Gly Ser 
225                 230                 235                 240 


Glu Glu Lys Gly Thr Tyr His Leu Ala Leu Phe Gly Asp Arg Ala Gln 
                245                 250                 255     


Glu Ile Ala Gly Ser Ala Thr Val Lys Ile Gly Glu Lys Val His Glu 
            260                 265                 270         


Ile Gly Ile Ala Gly Lys Gln 
        275                 


<210>  19
<211>  395
<212>  PRT
<213>  Neisseria meningitidis

<400>  19

Met Arg Lys Lys Leu Thr Ala Leu Val Leu Ser Ala Leu Pro Leu Ala 
1               5                   10                  15      


Ala Val Ala Asp Val Ser Leu Tyr Gly Glu Ile Lys Ala Gly Val Glu 
            20                  25                  30          


Gly Arg Asn Tyr Gln Leu Gln Leu Thr Glu Ala Gln Ala Ala Asn Gly 
        35                  40                  45              


Gly Ala Ser Gly Gln Val Lys Val Thr Lys Val Thr Lys Ala Lys Ser 
    50                  55                  60                  


Arg Ile Arg Thr Lys Ile Ser Asp Phe Gly Ser Phe Ile Gly Phe Lys 
65                  70                  75                  80  


Gly Ser Glu Asp Leu Gly Glu Gly Leu Lys Ala Val Trp Gln Leu Glu 
                85                  90                  95      


Gln Asp Val Ser Val Ala Gly Gly Gly Ala Thr Gln Trp Gly Asn Arg 
            100                 105                 110         


Glu Ser Phe Ile Gly Leu Ala Gly Glu Phe Gly Thr Leu Arg Ala Gly 
        115                 120                 125             


Arg Val Ala Asn Gln Phe Asp Asp Ala Ser Gln Ala Ile Asp Pro Trp 
    130                 135                 140                 


Asp Ser Asn Asn Asp Val Ala Ser Gln Leu Gly Ile Phe Lys Arg His 
145                 150                 155                 160 


Asp Asp Met Pro Val Ser Val Arg Tyr Asp Ser Pro Glu Phe Ser Gly 
                165                 170                 175     


Phe Ser Gly Ser Val Gln Phe Val Pro Ala Gln Asn Ser Lys Ser Ala 
            180                 185                 190         


Tyr Lys Pro Ala Tyr Trp Thr Thr Val Asn Thr Gly Ser Ala Thr Thr 
        195                 200                 205             


Thr Thr Phe Val Pro Ala Val Val Gly Lys Pro Gly Ser Asp Val Tyr 
    210                 215                 220                 


Tyr Ala Gly Leu Asn Tyr Lys Asn Gly Gly Phe Ala Gly Asn Tyr Ala 
225                 230                 235                 240 


Phe Lys Tyr Ala Arg His Ala Asn Val Gly Arg Asp Ala Phe Glu Leu 
                245                 250                 255     


Phe Leu Leu Gly Ser Gly Ser Asp Gln Ala Lys Gly Thr Asp Pro Leu 
            260                 265                 270         


Lys Asn His Gln Val His Arg Leu Thr Gly Gly Tyr Glu Glu Gly Gly 
        275                 280                 285             


Leu Asn Leu Ala Leu Ala Ala Gln Leu Asp Leu Ser Glu Asn Gly Asp 
    290                 295                 300                 


Lys Thr Lys Asn Ser Thr Thr Glu Ile Ala Ala Thr Ala Ser Tyr Arg 
305                 310                 315                 320 


Phe Gly Asn Ala Val Pro Arg Ile Ser Tyr Ala His Gly Phe Asp Phe 
                325                 330                 335     


Ile Glu Arg Gly Lys Lys Gly Glu Asn Thr Ser Tyr Asp Gln Ile Ile 
            340                 345                 350         


Ala Gly Val Asp Tyr Asp Phe Ser Lys Arg Thr Ser Ala Ile Val Ser 
        355                 360                 365             


Gly Ala Trp Leu Lys Arg Asn Thr Gly Ile Gly Asn Tyr Thr Gln Ile 
    370                 375                 380                 


Asn Ala Ala Ser Val Gly Leu Arg His Lys Phe 
385                 390                 395 


<210>  20
<211>  497
<212>  PRT
<213>  Neisseria meningitidis

<400>  20

Met Phe Lys Arg Ser Val Ile Ala Met Ala Cys Ile Val Ala Leu Ser 
1               5                   10                  15      


Ala Cys Gly Gly Gly Gly Gly Gly Ser Pro Asp Val Lys Ser Ala Asp 
            20                  25                  30          


Thr Leu Ser Lys Pro Ala Ala Pro Val Val Thr Glu Asp Val Gly Glu 
        35                  40                  45              


Glu Val Leu Pro Lys Glu Lys Lys Asp Glu Glu Ala Val Ser Gly Ala 
    50                  55                  60                  


Pro Gln Ala Asp Thr Gln Asp Ala Thr Ala Gly Lys Gly Gly Gln Asp 
65                  70                  75                  80  


Met Ala Ala Val Ser Ala Glu Asn Thr Gly Asn Gly Gly Ala Ala Thr 
                85                  90                  95      


Thr Asp Asn Pro Glu Asn Lys Asp Glu Gly Pro Gln Asn Asp Met Pro 
            100                 105                 110         


Gln Asn Ala Ala Asp Thr Asp Ser Ser Thr Pro Asn His Thr Pro Ala 
        115                 120                 125             


Pro Asn Met Pro Thr Arg Asp Met Gly Asn Gln Ala Pro Asp Ala Gly 
    130                 135                 140                 


Glu Ser Ala Gln Pro Ala Asn Gln Pro Asp Met Ala Asn Ala Ala Asp 
145                 150                 155                 160 


Gly Met Gln Gly Asp Asp Pro Ser Ala Gly Glu Asn Ala Gly Asn Thr 
                165                 170                 175     


Ala Asp Gln Ala Ala Asn Gln Ala Glu Asn Asn Gln Val Gly Gly Ser 
            180                 185                 190         


Gln Asn Pro Ala Ser Ser Thr Asn Pro Asn Ala Thr Asn Gly Gly Ser 
        195                 200                 205             


Asp Phe Gly Arg Ile Asn Val Ala Asn Gly Ile Lys Leu Asp Ser Gly 
    210                 215                 220                 


Ser Glu Asn Val Thr Leu Thr His Cys Lys Asp Lys Val Cys Asp Arg 
225                 230                 235                 240 


Asp Phe Leu Asp Glu Glu Ala Pro Pro Lys Ser Glu Phe Glu Lys Leu 
                245                 250                 255     


Ser Asp Glu Glu Lys Ile Asn Lys Tyr Lys Lys Asp Glu Gln Arg Glu 
            260                 265                 270         


Asn Phe Val Gly Leu Val Ala Asp Arg Val Glu Lys Asn Gly Thr Asn 
        275                 280                 285             


Lys Tyr Val Ile Ile Tyr Lys Asp Lys Ser Ala Ser Ser Ser Ser Ala 
    290                 295                 300                 


Arg Phe Arg Arg Ser Ala Arg Ser Arg Arg Ser Leu Pro Ala Glu Met 
305                 310                 315                 320 


Pro Leu Ile Pro Val Asn Gln Ala Asp Thr Leu Ile Val Asp Gly Glu 
                325                 330                 335     


Ala Val Ser Leu Thr Gly His Ser Gly Asn Ile Phe Ala Pro Glu Gly 
            340                 345                 350         


Asn Tyr Arg Tyr Leu Thr Tyr Gly Ala Glu Lys Leu Ser Gly Gly Ser 
        355                 360                 365             


Tyr Ala Leu Ser Val Gln Gly Glu Pro Ala Lys Gly Glu Met Leu Ala 
    370                 375                 380                 


Gly Thr Ala Val Tyr Asn Gly Glu Val Leu His Phe His Met Glu Asn 
385                 390                 395                 400 


Gly Arg Pro Ser Pro Ser Gly Gly Arg Phe Ala Ala Lys Val Asp Phe 
                405                 410                 415     


Gly Ser Lys Ser Val Asp Gly Ile Ile Asp Ser Gly Asp Asp Leu His 
            420                 425                 430         


Met Gly Thr Gln Lys Phe Lys Ala Val Ile Asp Gly Asn Gly Phe Lys 
        435                 440                 445             


Gly Thr Trp Thr Glu Asn Gly Gly Gly Asp Val Ser Gly Arg Phe Tyr 
    450                 455                 460                 


Gly Pro Ala Gly Glu Glu Val Ala Gly Lys Tyr Ser Tyr Arg Pro Thr 
465                 470                 475                 480 


Asp Ala Glu Lys Gly Gly Phe Gly Val Phe Ala Gly Lys Lys Glu Gln 
                485                 490                 495     


Asp 
    


<210>  21
<211>  364
<212>  PRT
<213>  Neisseria meningitidis

<400>  21

Met Ser Met Lys His Phe Pro Ser Lys Val Leu Thr Thr Ala Ile Leu 
1               5                   10                  15      


Ala Thr Phe Cys Ser Gly Ala Leu Ala Ala Thr Ser Asp Asp Asp Val 
            20                  25                  30          


Lys Lys Ala Ala Thr Val Ala Ile Val Ala Ala Tyr Asn Asn Gly Gln 
        35                  40                  45              


Glu Ile Asn Gly Phe Lys Ala Gly Glu Thr Ile Tyr Asp Ile Gly Glu 
    50                  55                  60                  


Asp Gly Thr Ile Thr Gln Lys Asp Ala Thr Ala Ala Asp Val Glu Ala 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Leu Gly Leu Lys Lys Val Val Thr Asn Leu Thr 
                85                  90                  95      


Lys Thr Val Asn Glu Asn Lys Gln Asn Val Asp Ala Lys Val Lys Ala 
            100                 105                 110         


Ala Glu Ser Glu Ile Glu Lys Leu Thr Thr Lys Leu Ala Asp Thr Asp 
        115                 120                 125             


Ala Ala Leu Ala Asp Thr Asp Ala Ala Leu Asp Glu Thr Thr Asn Ala 
    130                 135                 140                 


Leu Asn Lys Leu Gly Glu Asn Ile Thr Thr Phe Ala Glu Glu Thr Lys 
145                 150                 155                 160 


Thr Asn Ile Val Lys Ile Asp Glu Lys Leu Glu Ala Val Ala Asp Thr 
                165                 170                 175     


Val Asp Lys His Ala Glu Ala Phe Asn Asp Ile Ala Asp Ser Leu Asp 
            180                 185                 190         


Glu Thr Asn Thr Lys Ala Asp Glu Ala Val Lys Thr Ala Asn Glu Ala 
        195                 200                 205             


Lys Gln Thr Ala Glu Glu Thr Lys Gln Asn Val Asp Ala Lys Val Lys 
    210                 215                 220                 


Ala Ala Glu Thr Ala Ala Gly Lys Ala Glu Ala Ala Ala Gly Thr Ala 
225                 230                 235                 240 


Asn Thr Ala Ala Asp Lys Ala Glu Ala Val Ala Ala Lys Val Thr Asp 
                245                 250                 255     


Ile Lys Ala Asp Ile Ala Thr Asn Lys Ala Asp Ile Ala Lys Asn Ser 
            260                 265                 270         


Ala Arg Ile Asp Ser Leu Asp Lys Asn Val Ala Asn Leu Arg Lys Glu 
        275                 280                 285             


Thr Arg Gln Gly Leu Ala Glu Gln Ala Ala Leu Ser Gly Leu Phe Gln 
    290                 295                 300                 


Pro Tyr Asn Val Gly Arg Phe Asn Val Thr Ala Ala Val Gly Gly Tyr 
305                 310                 315                 320 


Lys Ser Glu Ser Ala Val Ala Ile Gly Thr Gly Phe Arg Phe Thr Glu 
                325                 330                 335     


Asn Phe Ala Ala Lys Ala Gly Val Ala Val Gly Thr Ser Ser Gly Ser 
            340                 345                 350         


Ser Ala Ala Tyr His Val Gly Val Asn Tyr Glu Trp 
        355                 360                 


<210>  22
<211>  313
<212>  PRT
<213>  Neisseria meningitidis

<400>  22

Met Lys Thr Leu Leu Leu Leu Ile Pro Leu Val Leu Thr Ala Cys Gly 
1               5                   10                  15      


Thr Leu Thr Gly Ile Pro Ala His Gly Gly Gly Lys Arg Phe Ala Val 
            20                  25                  30          


Glu Gln Glu Leu Val Ala Ala Ser Ser Arg Ala Ala Val Lys Glu Met 
        35                  40                  45              


Asp Leu Ser Ala Leu Lys Gly Arg Lys Ala Ala Leu Tyr Val Ser Val 
    50                  55                  60                  


Met Gly Asp Gln Gly Ser Gly Asn Ile Ser Gly Gly Arg Tyr Ser Ile 
65                  70                  75                  80  


Asp Ala Leu Ile Arg Gly Gly Tyr His Asn Asn Pro Glu Ser Ala Thr 
                85                  90                  95      


Gln Tyr Ser Tyr Pro Ala Tyr Asp Thr Thr Ala Thr Thr Lys Ser Asp 
            100                 105                 110         


Ala Leu Ser Ser Val Thr Thr Ser Thr Ser Leu Leu Asn Ala Pro Ala 
        115                 120                 125             


Ala Ala Leu Thr Lys Asn Ser Gly Arg Lys Gly Glu Arg Ser Ala Gly 
    130                 135                 140                 


Leu Ser Val Asn Gly Thr Gly Asp Tyr Arg Asn Glu Thr Leu Leu Ala 
145                 150                 155                 160 


Asn Pro Arg Asp Val Ser Phe Leu Thr Asn Leu Ile Gln Thr Val Phe 
                165                 170                 175     


Tyr Leu Arg Gly Ile Glu Val Val Pro Pro Glu Tyr Ala Asp Thr Asp 
            180                 185                 190         


Val Phe Val Thr Val Asp Val Phe Gly Thr Val Arg Ser Arg Thr Glu 
        195                 200                 205             


Leu His Leu Tyr Asn Ala Glu Thr Leu Lys Ala Gln Thr Lys Leu Glu 
    210                 215                 220                 


Tyr Phe Ala Val Asp Arg Asp Ser Arg Lys Leu Leu Ile Ala Pro Lys 
225                 230                 235                 240 


Thr Ala Ala Tyr Glu Ser Gln Tyr Gln Glu Gln Tyr Ala Leu Trp Met 
                245                 250                 255     


Gly Pro Tyr Ser Val Gly Lys Thr Val Lys Ala Ser Asp Arg Leu Met 
            260                 265                 270         


Val Asp Phe Ser Asp Ile Thr Pro Tyr Gly Asp Thr Thr Ala Gln Asn 
        275                 280                 285             


Arg Pro Asp Phe Lys Gln Asn Asn Gly Lys Lys Pro Asp Val Gly Asn 
    290                 295                 300                 


Glu Val Ile Arg Arg Arg Lys Gly Gly 
305                 310             


<210>  23
<211>  313
<212>  PRT
<213>  Neisseria meningitidis

<400>  23

Met Lys Thr Leu Leu Leu Leu Ile Pro Leu Val Leu Thr Ala Cys Gly 
1               5                   10                  15      


Thr Leu Thr Gly Ile Pro Ala His Gly Gly Gly Lys Arg Phe Ala Val 
            20                  25                  30          


Glu Gln Glu Leu Val Ala Ala Ser Ser Arg Ala Ala Val Lys Glu Met 
        35                  40                  45              


Asp Leu Ser Ala Leu Lys Gly Arg Lys Ala Ala Leu Tyr Val Ser Val 
    50                  55                  60                  


Met Gly Asp Gln Gly Ser Gly Asn Ile Ser Gly Gly Arg Tyr Ser Ile 
65                  70                  75                  80  


Asp Ala Leu Ile Arg Gly Gly Tyr His Asn Asn Pro Glu Ser Thr Thr 
                85                  90                  95      


Gln Tyr Ser Tyr Pro Ala Tyr Asp Thr Thr Ala Thr Thr Lys Ala Asp 
            100                 105                 110         


Ala Leu Ser Ser Val Thr Thr Ser Thr Ser Leu Leu Asn Ala Pro Ala 
        115                 120                 125             


Ala Ala Leu Thr Lys Asn Ser Gly Arg Lys Gly Glu Arg Ser Ala Gly 
    130                 135                 140                 


Leu Ser Val Asn Gly Thr Gly Asp Tyr Arg Asn Glu Thr Leu Leu Ala 
145                 150                 155                 160 


Asn Pro Arg Asp Val Ser Phe Leu Thr Asn Leu Ile Gln Thr Val Phe 
                165                 170                 175     


Tyr Leu Arg Gly Ile Glu Val Val Pro Pro Glu Tyr Ala Asp Thr Asp 
            180                 185                 190         


Val Phe Val Thr Val Asp Val Phe Gly Thr Val Arg Ser Arg Thr Glu 
        195                 200                 205             


Leu His Leu Tyr Asn Ala Glu Thr Leu Lys Ala Gln Thr Lys Leu Glu 
    210                 215                 220                 


Tyr Phe Ala Val Asp Arg Asp Ser Arg Lys Leu Leu Ile Ala Pro Lys 
225                 230                 235                 240 


Thr Ala Ala Tyr Glu Ser Gln Tyr Gln Glu Gln Tyr Ala Leu Trp Met 
                245                 250                 255     


Gly Pro Tyr Ser Val Gly Lys Thr Val Lys Ala Ser Asp Arg Leu Met 
            260                 265                 270         


Val Asp Phe Ser Asp Ile Thr Pro Tyr Gly Asp Thr Thr Ala Gln Asn 
        275                 280                 285             


Arg Pro Asp Phe Lys Gln Asn Asn Gly Lys Asn Pro Asp Val Gly Asn 
    290                 295                 300                 


Glu Val Ile Arg Arg Arg Lys Gly Gly 
305                 310             


<210>  24
<211>  320
<212>  PRT
<213>  Neisseria meningitidis

<400>  24

Met Gln Ala Arg Leu Leu Ile Pro Ile Leu Phe Ser Val Phe Ile Leu 
1               5                   10                  15      


Ser Ala Cys Gly Thr Leu Thr Gly Ile Pro Ser His Gly Gly Gly Lys 
            20                  25                  30          


Arg Phe Ala Val Glu Gln Glu Leu Val Ala Ala Ser Ala Arg Ala Ala 
        35                  40                  45              


Val Lys Asp Met Asp Leu Gln Ala Leu His Gly Arg Lys Val Ala Leu 
    50                  55                  60                  


Tyr Ile Ala Thr Met Gly Asp Gln Gly Ser Gly Ser Leu Thr Gly Gly 
65                  70                  75                  80  


Arg Tyr Ser Ile Asp Ala Leu Ile Arg Gly Glu Tyr Ile Asn Ser Pro 
                85                  90                  95      


Ala Val Arg Thr Asp Tyr Thr Tyr Pro Arg Tyr Glu Thr Thr Ala Glu 
            100                 105                 110         


Thr Thr Ser Gly Gly Leu Thr Gly Leu Thr Thr Ser Leu Ser Thr Leu 
        115                 120                 125             


Asn Ala Pro Ala Arg Ser Arg Thr Gln Ser Asp Gly Ser Gly Ser Arg 
    130                 135                 140                 


Ser Ser Leu Gly Leu Asn Ile Gly Gly Met Gly Asp Tyr Arg Asn Glu 
145                 150                 155                 160 


Thr Leu Thr Thr Asn Pro Arg Asp Thr Ala Phe Leu Ser His Leu Val 
                165                 170                 175     


Gln Thr Val Phe Phe Leu Arg Gly Ile Asp Val Val Ser Pro Ala Asn 
            180                 185                 190         


Ala Asp Thr Asp Val Phe Ile Asn Ile Asp Val Phe Gly Thr Ile Arg 
        195                 200                 205             


Asn Arg Thr Glu Met His Leu Tyr Asn Ala Glu Thr Leu Lys Ala Gln 
    210                 215                 220                 


Thr Lys Leu Glu Tyr Phe Ala Val Asp Arg Thr Asn Lys Lys Leu Leu 
225                 230                 235                 240 


Ile Lys Pro Lys Thr Asn Ala Phe Glu Ala Val Tyr Lys Glu Asn Tyr 
                245                 250                 255     


Ala Leu Trp Met Gly Pro Tyr Lys Val Ser Lys Gly Ile Lys Pro Thr 
            260                 265                 270         


Glu Gly Leu Met Val Asp Phe Ser Asp Ile Arg Pro Tyr Gly Asn His 
        275                 280                 285             


Thr Gly Asn Ser Ala Pro Ser Val Glu Thr Asp Asn Ser His Glu Gly 
    290                 295                 300                 


Tyr Gly Tyr Ser Asp Glu Val Val Arg Gln His Arg Gln Gly Gln Pro 
305                 310                 315                 320 


<210>  25
<211>  174
<212>  PRT
<213>  Neisseria meningitidis

<400>  25

Met Lys Lys Ala Leu Ala Ala Leu Ile Ala Leu Ala Leu Pro Ala Ala 
1               5                   10                  15      


Ala Leu Ala Glu Gly Ala Ser Gly Phe Tyr Val Gln Ala Asp Ala Ala 
            20                  25                  30          


His Ala Lys Ala Ser Ser Ser Leu Gly Ser Ala Lys Gly Phe Ser Pro 
        35                  40                  45              


Arg Ile Ser Ala Gly Tyr Arg Ile Asn Asp Leu Arg Phe Ala Val Asp 
    50                  55                  60                  


Tyr Thr Arg Tyr Lys Asn Tyr Lys Ala Pro Ser Thr Asp Phe Lys Leu 
65                  70                  75                  80  


Tyr Ser Ile Gly Ala Ser Ala Ile Tyr Asp Phe Asp Thr Gln Ser Pro 
                85                  90                  95      


Val Lys Pro Tyr Leu Gly Ala Arg Leu Ser Leu Asn Arg Ala Ser Val 
            100                 105                 110         


Asp Leu Gly Gly Ser Asp Ser Phe Ser Gln Thr Ser Thr Gly Leu Gly 
        115                 120                 125             


Val Leu Ala Gly Val Ser Tyr Ala Val Thr Pro Asn Val Asp Leu Asp 
    130                 135                 140                 


Ala Gly Tyr Arg Tyr Asn Tyr Ile Gly Lys Val Asn Thr Val Lys Asn 
145                 150                 155                 160 


Val Arg Ser Gly Glu Leu Ser Val Gly Val Arg Val Lys Phe 
                165                 170                 


<210>  26
<211>  792
<212>  PRT
<213>  Neisseria meningitidis

<400>  26

Met Lys Pro Leu Gln Met Leu Pro Ile Ala Ala Leu Val Gly Ser Ile 
1               5                   10                  15      


Phe Gly Asn Pro Val Phe Ala Ala Asp Glu Ala Ala Thr Glu Thr Thr 
            20                  25                  30          


Pro Val Lys Ala Glu Val Lys Ala Val Arg Val Lys Gly Gln Arg Asn 
        35                  40                  45              


Ala Pro Ala Ala Val Glu Arg Val Asn Leu Asn Arg Ile Lys Gln Glu 
    50                  55                  60                  


Met Ile Arg Asp Asn Lys Asp Leu Val Arg Tyr Ser Thr Asp Val Gly 
65                  70                  75                  80  


Leu Ser Asp Ser Gly Arg His Gln Lys Gly Phe Ala Val Arg Gly Val 
                85                  90                  95      


Glu Gly Asn Arg Val Gly Val Ser Ile Asp Gly Val Asn Leu Pro Asp 
            100                 105                 110         


Ser Glu Glu Asn Ser Leu Tyr Ala Arg Tyr Gly Asn Phe Asn Ser Ser 
        115                 120                 125             


Arg Leu Ser Ile Asp Pro Glu Leu Val Arg Asn Ile Asp Ile Val Lys 
    130                 135                 140                 


Gly Ala Asp Ser Phe Asn Thr Gly Ser Gly Ala Leu Gly Gly Gly Val 
145                 150                 155                 160 


Asn Tyr Gln Thr Leu Gln Gly Arg Asp Leu Leu Leu Pro Glu Arg Gln 
                165                 170                 175     


Phe Gly Val Met Met Lys Asn Gly Tyr Ser Thr Arg Asn Arg Glu Trp 
            180                 185                 190         


Thr Asn Thr Leu Gly Phe Gly Val Ser Asn Asp Arg Val Asp Ala Ala 
        195                 200                 205             


Leu Leu Tyr Ser Gln Arg Arg Gly His Glu Thr Glu Ser Ala Gly Lys 
    210                 215                 220                 


Arg Gly Tyr Pro Val Glu Gly Ala Gly Ser Gly Ala Asn Ile Arg Gly 
225                 230                 235                 240 


Ser Ala Arg Gly Ile Pro Asp Pro Ser Gln His Lys Tyr His Ser Phe 
                245                 250                 255     


Leu Gly Lys Ile Ala Tyr Gln Ile Asn Asp Asn His Arg Ile Gly Ala 
            260                 265                 270         


Ser Leu Asn Gly Gln Gln Gly His Asn Tyr Thr Val Glu Glu Ser Tyr 
        275                 280                 285             


Asn Leu Leu Ala Ser Tyr Trp Arg Glu Ala Asp Asp Val Asn Arg Arg 
    290                 295                 300                 


Arg Asn Thr Asn Leu Phe Tyr Glu Trp Thr Pro Glu Ser Asp Arg Leu 
305                 310                 315                 320 


Ser Met Val Lys Ala Asp Val Asp Tyr Gln Lys Thr Lys Val Ser Ala 
                325                 330                 335     


Val Asn Tyr Lys Gly Ser Phe Pro Ile Glu Asp Ser Ser Thr Leu Thr 
            340                 345                 350         


Arg Asn Tyr Asn Gln Lys Asp Leu Asp Glu Ile Tyr Asn Arg Ser Met 
        355                 360                 365             


Asp Thr Arg Phe Lys Arg Ile Thr Leu Arg Leu Asp Ser His Pro Leu 
    370                 375                 380                 


Gln Leu Gly Gly Gly Arg His Arg Leu Ser Phe Lys Thr Phe Ala Ser 
385                 390                 395                 400 


Arg Arg Asp Phe Glu Asn Leu Asn Arg Asp Asp Tyr Tyr Phe Ser Gly 
                405                 410                 415     


Arg Val Val Arg Thr Thr Ser Ser Ile Gln His Pro Val Lys Thr Thr 
            420                 425                 430         


Asn Tyr Gly Phe Ser Leu Ser Asp Gln Ile Gln Trp Asn Asp Val Phe 
        435                 440                 445             


Ser Ser Arg Ala Gly Ile Arg Tyr Asp His Thr Lys Met Thr Pro Gln 
    450                 455                 460                 


Glu Leu Asn Ala Glu Cys His Ala Cys Asp Lys Thr Pro Pro Ala Ala 
465                 470                 475                 480 


Asn Thr Tyr Lys Gly Trp Ser Gly Phe Val Gly Leu Ala Ala Gln Leu 
                485                 490                 495     


Asn Gln Ala Trp Arg Val Gly Tyr Asp Ile Thr Ser Gly Tyr Arg Val 
            500                 505                 510         


Pro Asn Ala Ser Glu Val Tyr Phe Thr Tyr Asn His Gly Ser Gly Asn 
        515                 520                 525             


Trp Leu Pro Asn Pro Asn Leu Lys Ala Glu Arg Ser Thr Thr His Thr 
    530                 535                 540                 


Leu Ser Leu Gln Gly Arg Ser Glu Lys Gly Thr Leu Asp Ala Asn Leu 
545                 550                 555                 560 


Tyr Gln Ser Asn Tyr Arg Asn Phe Leu Ser Glu Glu Gln Lys Leu Thr 
                565                 570                 575     


Thr Ser Gly Asp Val Ser Cys Thr Gln Met Asn Tyr Tyr Tyr Gly Met 
            580                 585                 590         


Cys Ser Asn Pro Tyr Ser Glu Lys Leu Glu Trp Gln Met Gln Asn Ile 
        595                 600                 605             


Asp Lys Ala Arg Ile Arg Gly Ile Glu Leu Thr Gly Arg Leu Asn Val 
    610                 615                 620                 


Asp Lys Val Ala Ser Phe Val Pro Glu Gly Trp Lys Leu Phe Gly Ser 
625                 630                 635                 640 


Leu Gly Tyr Ala Lys Ser Lys Leu Ser Gly Asp Asn Ser Leu Leu Ser 
                645                 650                 655     


Thr Gln Pro Leu Lys Val Ile Ala Gly Ile Asp Tyr Glu Ser Pro Ser 
            660                 665                 670         


Glu Lys Trp Gly Val Phe Ser Arg Leu Thr Tyr Leu Gly Ala Lys Lys 
        675                 680                 685             


Val Lys Asp Ala Gln Tyr Thr Val Tyr Glu Asn Lys Gly Trp Gly Thr 
    690                 695                 700                 


Pro Leu Gln Lys Lys Val Lys Asp Tyr Pro Trp Leu Asn Lys Ser Ala 
705                 710                 715                 720 


Tyr Val Phe Asp Met Tyr Gly Phe Tyr Lys Pro Val Lys Asn Leu Thr 
                725                 730                 735     


Leu Arg Ala Gly Val Tyr Asn Val Phe Asn Arg Lys Tyr Thr Thr Trp 
            740                 745                 750         


Asp Ser Leu Arg Gly Leu Tyr Ser Tyr Ser Thr Thr Asn Ser Val Asp 
        755                 760                 765             


Arg Asp Gly Lys Gly Leu Asp Arg Tyr Arg Ala Pro Ser Arg Asn Tyr 
    770                 775                 780                 


Ala Val Ser Leu Glu Trp Lys Phe 
785                 790         


<210>  27
<211>  720
<212>  PRT
<213>  Neisseria meningitidis

<400>  27

Met Asn Asn Pro Leu Val Asn Gln Ala Ala Met Val Leu Pro Val Phe 
1               5                   10                  15      


Leu Leu Ser Ala Cys Leu Gly Gly Gly Gly Ser Phe Asp Leu Asp Ser 
            20                  25                  30          


Val Asp Thr Glu Ala Pro Arg Pro Ala Pro Lys Tyr Gln Asp Val Ser 
        35                  40                  45              


Ser Glu Lys Pro Gln Ala Gln Lys Asp Gln Gly Gly Tyr Gly Phe Ala 
    50                  55                  60                  


Met Arg Phe Lys Arg Arg Asn Trp Tyr Pro Gln Ala Asn Pro Lys Glu 
65                  70                  75                  80  


Asp Glu Ile Lys Leu Ser Glu Asn Asp Trp Glu Ala Thr Gly Leu Pro 
                85                  90                  95      


Gly Asn Pro Lys Asn Leu Pro Glu Arg Gln Lys Ser Val Ile Glu Lys 
            100                 105                 110         


Val Lys Thr Gly Ser Asp Ser Asn Ile Tyr Ser Ser Pro Tyr Leu Thr 
        115                 120                 125             


Gln Ser Asn His Gln Asn Gly Ser Ala Asn Gln Pro Lys Asn Glu Val 
    130                 135                 140                 


Lys Asp Tyr Lys Glu Phe Lys Tyr Val Tyr Ser Gly Trp Phe Tyr Lys 
145                 150                 155                 160 


His Ala Lys Leu Glu Ile Ile Lys Glu Asn Asn Leu Ile Lys Gly Ala 
                165                 170                 175     


Lys Ser Gly Asp Asp Gly Tyr Ile Phe Tyr His Gly Glu Lys Pro Ser 
            180                 185                 190         


Arg Gln Leu Pro Val Ser Gly Glu Val Thr Tyr Lys Gly Val Trp His 
        195                 200                 205             


Phe Val Thr Asp Thr Lys Gln Gly Gln Lys Phe Asn Asp Ile Leu Gly 
    210                 215                 220                 


Thr Ser Lys Lys Gln Gly Asp Arg Tyr Ser Gly Phe Pro Gly Asp Asp 
225                 230                 235                 240 


Gly Glu Glu Tyr Ser Asn Lys Asn Glu Ala Thr Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Gly Tyr Gly Phe Thr Ser Asn Leu Lys Val Asp Phe Asn Lys Lys 
            260                 265                 270         


Lys Leu Thr Gly Glu Leu Ile Arg Asn Asn Arg Val Thr Asn Ala Thr 
        275                 280                 285             


Ala Ser Asp Lys His Thr Thr Gln Tyr Tyr Ser Leu Glu Ala Gln Val 
    290                 295                 300                 


Thr Gly Asn Arg Phe Asn Gly Lys Ala Met Ala Thr Asp Lys Pro Gly 
305                 310                 315                 320 


Asn Gly Glu Thr Lys Gln His Pro Phe Val Ser Asp Ser Ser Ser Leu 
                325                 330                 335     


Ser Gly Gly Phe Phe Gly Pro Lys Gly Glu Glu Leu Gly Phe Arg Phe 
            340                 345                 350         


Leu Ser Asp Asp Lys Lys Val Ala Val Val Gly Ser Ala Lys Thr Lys 
        355                 360                 365             


Asp Lys Asp Ala Asn Gly Asn Thr Glu Ala Ala Ser Gly Gly Thr Gly 
    370                 375                 380                 


Ala Ala Ala Ser Gly Gly Ala Ala Ala Met Pro Ser Glu Asn Gly Lys 
385                 390                 395                 400 


Leu Thr Thr Val Leu Asp Ala Val Glu Leu Thr Arg Gly Gly Lys Ala 
                405                 410                 415     


Ile Lys Asn Leu Asp Asn Phe Ser Asn Ala Ala Gln Leu Val Val Asp 
            420                 425                 430         


Gly Ile Met Ile Pro Leu Leu Pro Lys Asp Ser Glu Ser Gly Asn Asn 
        435                 440                 445             


Gln Ala Asp Lys Gly Lys Asn Gly Lys Asn Gly Lys Asn Gly Gly Thr 
    450                 455                 460                 


Asp Phe Thr Tyr Lys Thr Thr Tyr Thr Pro Lys Ser Asp Glu Lys Asp 
465                 470                 475                 480 


Thr Gln Ala Gly Thr Pro Thr Asn Gly Ala Gln Thr Ala Ser Asn Thr 
                485                 490                 495     


Ala Gly Asp Thr Asn Gly Lys Thr Lys Thr Tyr Glu Val Glu Val Cys 
            500                 505                 510         


Cys Ser Asn Leu Asn Tyr Leu Lys Tyr Gly Met Leu Thr Arg Lys Asn 
        515                 520                 525             


Ser Lys Ser Ala Met Gln Ala Gly Glu Ser Ser Ser Gln Ala Asp Ala 
    530                 535                 540                 


Lys Thr Glu Gln Val Glu Gln Ser Met Phe Leu Gln Gly Glu Arg Thr 
545                 550                 555                 560 


Asp Glu Lys Glu Ile Pro Lys Glu Gln Asn Val Val Tyr Arg Gly Ser 
                565                 570                 575     


Trp Tyr Gly His Ile Ala Asn Asp Thr Ser Trp Ser Gly Asn Ala Ser 
            580                 585                 590         


Asp Lys Glu Gly Gly Asn Arg Ala Glu Phe Thr Val Asp Phe Ala Asp 
        595                 600                 605             


Lys Lys Ile Thr Gly Lys Leu Thr Ala Glu Asn Arg Gln Ala Gln Thr 
    610                 615                 620                 


Phe Thr Ile Glu Gly Met Ile Gln Gly Asn Gly Phe Glu Gly Thr Ala 
625                 630                 635                 640 


Lys Thr Ala Glu Ser Gly Phe Asp Leu Asp Gln Lys Asn Thr Thr Arg 
                645                 650                 655     


Thr Pro Lys Ala Tyr Ile Thr Asp Ala Lys Val Lys Gly Gly Phe Tyr 
            660                 665                 670         


Gly Pro Lys Ala Glu Glu Leu Gly Gly Trp Phe Ala Tyr Pro Gly Asp 
        675                 680                 685             


Lys Gln Thr Lys Asn Ala Thr Ala Thr Ser Ser Asp Gly Lys Ser Ala 
    690                 695                 700                 


Ser Ser Ala Thr Val Val Phe Gly Ala Lys Arg Gln Gln Pro Val Arg 
705                 710                 715                 720 


<210>  28
<211>  972
<212>  PRT
<213>  Neisseria meningitidis

<400>  28

Pro Pro Pro Asn Leu His Thr Gly Asp Phe Thr Asn Pro Asn Asp Ala 
1               5                   10                  15      


Tyr Lys Asn Leu Ile Asn Leu Lys Pro Ala Ile Glu Ala Gly Tyr Thr 
            20                  25                  30          


Gly Arg Gly Val Glu Val Gly Ile Val Asp Thr Gly Glu Ser Val Gly 
        35                  40                  45              


Ser Ile Ser Phe Pro Glu Leu Tyr Gly Arg Lys Glu His Gly Tyr Asn 
    50                  55                  60                  


Glu Asn Tyr Lys Asn Tyr Thr Ala Tyr Met Arg Lys Glu Ala Pro Glu 
65                  70                  75                  80  


Asp Gly Gly Gly Lys Asp Ile Glu Ala Ser Phe Asp Asp Glu Ala Val 
                85                  90                  95      


Ile Glu Thr Glu Ala Lys Pro Thr Asp Ile Arg His Val Lys Glu Ile 
            100                 105                 110         


Gly His Ile Asp Val Val Ser His Ile Ile Gly Gly Arg Ser Val Asp 
        115                 120                 125             


Gly Arg Pro Ala Gly Gly Ile Ala Pro Asp Ala Thr Leu His Ile Met 
    130                 135                 140                 


Asn Thr His Asp Gly Thr Lys Asn Glu Ile Met Ser Ala Ala Ile Arg 
145                 150                 155                 160 


Asn Ala Trp Val Lys Leu Gly Glu Arg Gly Val Arg Ile Val Asn Asn 
                165                 170                 175     


Ser Phe Gly Thr Thr Ser Arg Ala Gly Thr Ala Asp Leu Phe Gln Ile 
            180                 185                 190         


Ala Asn Ser Glu Glu Gln Tyr Arg Gln Ala Leu Leu Asp Tyr Ser Gly 
        195                 200                 205             


Gly Asp Lys Thr Asp Glu Gly Ile Arg Leu Met Gln Gln Ser Asp Tyr 
    210                 215                 220                 


Gly Asn Leu Ser Tyr His Ile Arg Asn Lys Asn Met Leu Phe Ile Phe 
225                 230                 235                 240 


Ser Ala Ser Asn Asp Ala Gln Ala Gln Pro Asn Thr Leu Thr Leu Leu 
                245                 250                 255     


Pro Phe Tyr Glu Lys Asp Ala Gln Lys Gly Ile Ile Thr Val Ala Gly 
            260                 265                 270         


Val Asp Arg Ser Gly Glu Lys Phe Asn Gly Ser Asn His Cys Gly Ile 
        275                 280                 285             


Thr Ala Met Trp Cys Leu Ser Ala Pro Tyr Glu Ala Ser Val Arg Phe 
    290                 295                 300                 


Thr Arg Thr Asn Pro Ile Gln Ile Ala Gly Thr Ser Phe Ser Ala Pro 
305                 310                 315                 320 


Ile Val Thr Gly Thr Ala Ala Leu Leu Leu Gln Lys Tyr Pro Trp Met 
                325                 330                 335     


Ser Asn Asp Asn Leu Arg Thr Thr Leu Leu Thr Thr Ala Gln Asp Ile 
            340                 345                 350         


Gly Ala Val Gly Val Asp Ser Lys Phe Gly Trp Gly Leu Leu Asp Ala 
        355                 360                 365             


Gly Lys Ala Met Asn Gly Pro Ala Ser Phe Pro Phe Gly Asp Phe Thr 
    370                 375                 380                 


Ala Asp Thr Lys Gly Thr Ser Asp Ile Ala Tyr Ser Phe Arg Asn Asp 
385                 390                 395                 400 


Ile Ser Gly Thr Gly Gly Leu Ile Lys Lys Gly Gly Ser Gln Leu Gln 
                405                 410                 415     


Leu His Gly Asn Asn Thr Tyr Thr Gly Lys Thr Val Ile Glu Gly Gly 
            420                 425                 430         


Ser Leu Val Leu Tyr Gly Asn Asn Glu Ser Asp Met Arg Val Glu Thr 
        435                 440                 445             


Lys Gly Ala Leu Ile Tyr Asn Gly Ala Ala Ser Gly Gly Ser Leu Asn 
    450                 455                 460                 


Ser Asp Gly Ile Val Tyr Leu Ala Asp Thr Asp Arg Ser Gly Ala Asn 
465                 470                 475                 480 


Glu Thr Val His Ile Lys Gly Asp Leu Gln Leu Gly Gly Glu Gly Thr 
                485                 490                 495     


Leu Tyr Thr Arg Leu Gly Lys Leu Leu Lys Val Asp Gly Thr Ala Met 
            500                 505                 510         


Thr Gly Gly Lys Leu Tyr Met Ser Ala Arg Gly Lys Gly Ala Gly Tyr 
        515                 520                 525             


Leu Asn Arg Thr Gly Gln Arg Val Pro Phe Leu Ser Ala Ala Lys Ile 
    530                 535                 540                 


Gly Arg Asp Tyr Ser Phe Phe Thr Asn Ile Glu Thr Asp Gly Gly Leu 
545                 550                 555                 560 


Leu Ala Ser Leu Asp Ser Val Glu Lys Thr Ala Gly Ser Glu Gly Asp 
                565                 570                 575     


Thr Leu Ser Tyr Tyr Val Arg Arg Gly Asn Ala Ala Arg Thr Ala Ser 
            580                 585                 590         


Ala Ala Ala His Ser Ala Pro Ala Gly Leu Lys His Ala Val Glu Gln 
        595                 600                 605             


Gly Gly Ser Asn Leu Glu Asn Leu Met Val Glu Leu Asp Ala Ser Glu 
    610                 615                 620                 


Ser Ser Ala Thr Pro Glu Thr Val Glu Thr Ala Ala Ala Asp Arg Thr 
625                 630                 635                 640 


Asp Met Pro Gly Ile Arg Pro Tyr Gly Ala Thr Phe Arg Ala Ala Ala 
                645                 650                 655     


Ala Val Gln His Ala Asn Ala Ala Asp Gly Val Arg Ile Phe Asn Ser 
            660                 665                 670         


Leu Ala Ala Thr Val Tyr Ala Asp Ser Thr Ala Ala His Ala Asp Met 
        675                 680                 685             


Gln Gly Arg Arg Leu Lys Ala Val Ser Asp Gly Leu Asp His Asn Ala 
    690                 695                 700                 


Thr Gly Leu Arg Val Ile Ala Gln Thr Gln Gln Asp Gly Gly Thr Trp 
705                 710                 715                 720 


Glu Gln Gly Gly Val Glu Gly Lys Met Arg Gly Ser Thr Gln Thr Val 
                725                 730                 735     


Gly Ile Ala Ala Lys Thr Gly Glu Asn Thr Thr Ala Ala Ala Thr Leu 
            740                 745                 750         


Gly Met Gly His Ser Thr Trp Ser Glu Asn Ser Ala Asn Ala Lys Thr 
        755                 760                 765             


Asp Ser Ile Ser Leu Phe Ala Gly Ile Arg His Asp Ala Gly Asp Ile 
    770                 775                 780                 


Gly Tyr Leu Lys Gly Leu Phe Ser Tyr Gly Arg Tyr Lys Asn Ser Ile 
785                 790                 795                 800 


Ser Arg Ser Thr Gly Ala Asp Glu His Ala Glu Gly Ser Val Asn Gly 
                805                 810                 815     


Thr Leu Met Gln Leu Gly Ala Leu Gly Gly Val Asn Val Pro Phe Ala 
            820                 825                 830         


Ala Thr Gly Asp Leu Thr Val Glu Gly Gly Leu Arg Tyr Asp Leu Leu 
        835                 840                 845             


Lys Gln Asp Ala Phe Ala Glu Lys Gly Ser Ala Leu Gly Trp Ser Gly 
    850                 855                 860                 


Asn Ser Leu Thr Glu Gly Thr Leu Val Gly Leu Ala Gly Leu Lys Leu 
865                 870                 875                 880 


Ser Gln Pro Leu Ser Asp Lys Ala Val Leu Phe Ala Thr Ala Gly Val 
                885                 890                 895     


Glu Arg Asp Leu Asn Gly Arg Asp Tyr Thr Val Thr Gly Gly Phe Thr 
            900                 905                 910         


Gly Ala Thr Ala Ala Thr Gly Lys Thr Gly Ala Arg Asn Met Pro His 
        915                 920                 925             


Thr Arg Leu Val Ala Gly Leu Gly Ala Asp Val Glu Phe Gly Asn Gly 
    930                 935                 940                 


Trp Asn Gly Leu Ala Arg Tyr Ser Tyr Ala Gly Ser Lys Gln Tyr Gly 
945                 950                 955                 960 


Asn His Ser Gly Arg Val Gly Val Gly Tyr Arg Phe 
                965                 970         


<210>  29
<211>  52
<212>  PRT
<213>  Neisseria meningitidis

<400>  29

Phe Thr Leu Ile Glu Leu Met Ile Val Ile Ala Ile Val Gly Ile Leu 
1               5                   10                  15      


Ala Ala Val Ala Leu Pro Ala Tyr Gln Asp Tyr Thr Ala Arg Ala Gln 
            20                  25                  30          


Val Ser Glu Ala Ile Leu Leu Ala Glu Gly Gln Lys Ser Ala Val Thr 
        35                  40                  45              


Glu Tyr Tyr Leu 
    50          


<210>  30
<211>  53
<212>  PRT
<213>  Neisseria meningitidis

<400>  30

Phe Thr Leu Leu Glu Leu Met Ile Ala Val Ala Ile Leu Gly Ile Leu 
1               5                   10                  15      


Thr Leu Ile Thr Tyr Pro Ser Tyr Lys Thr Tyr Ile Arg Arg Val Arg 
            20                  25                  30          


Leu Ser Glu Val Arg Thr Thr Leu Leu His Asn Ala Gln Thr Met Glu 
        35                  40                  45              


Arg Tyr Tyr Arg Gln 
    50              


<210>  31
<211>  117
<212>  PRT
<213>  Neisseria meningitidis

<400>  31

Ser Ala Val Thr Glu Tyr Tyr Leu Asn His Gly Glu Trp Pro Gly Asp 
1               5                   10                  15      


Asn Ser Ser Ala Gly Val Ala Thr Ser Ala Asp Ile Lys Gly Lys Tyr 
            20                  25                  30          


Val Gln Ser Val Thr Val Ala Asn Gly Val Ile Thr Ala Gln Met Ala 
        35                  40                  45              


Ser Ser Asn Val Asn Asn Glu Ile Lys Ser Lys Lys Leu Ser Leu Trp 
    50                  55                  60                  


Ala Lys Arg Gln Asn Gly Ser Val Lys Trp Phe Cys Gly Gln Pro Val 
65                  70                  75                  80  


Thr Arg Thr Thr Ala Thr Ala Thr Asp Val Ala Ala Ala Asn Gly Lys 
                85                  90                  95      


Thr Asp Asp Lys Ile Asn Thr Lys His Leu Pro Ser Thr Cys Arg Asp 
            100                 105                 110         


Asp Ser Ser Ala Ser 
        115         


<210>  32
<211>  76
<212>  PRT
<213>  Neisseria meningitidis

<400>  32

Thr Met Glu Arg Tyr Tyr Arg Gln Lys Gly Thr Phe Lys Thr Tyr Asp 
1               5                   10                  15      


Lys Asn Lys Leu Lys Gln Asn Lys Tyr Phe Asn Val Thr Leu Ser Lys 
            20                  25                  30          


Val Ser Pro Asp His Phe Thr Leu Gln Ala Asp Pro Asn Pro Thr Thr 
        35                  40                  45              


Asn Asp Gly Glu Thr Cys Val Val Thr Leu Asp Gly Gly Thr Ile Ala 
    50                  55                  60                  


Ala Ser Gly Thr Asn Gln Ser Cys Pro Gly Phe Asp 
65                  70                  75      


<210>  33
<211>  35
<212>  PRT
<213>  Neisseria meningitidis

<400>  33

Cys Gly Gln Pro Val Thr Arg Thr Thr Ala Thr Ala Thr Asp Val Ala 
1               5                   10                  15      


Ala Ala Asn Gly Lys Thr Asp Asp Lys Ile Asn Thr Lys His Leu Pro 
            20                  25                  30          


Ser Thr Cys 
        35  


<210>  34
<211>  27
<212>  PRT
<213>  Neisseria meningitidis

<400>  34

Gly Glu Thr Cys Val Val Thr Leu Asn Asp Gly Gly Thr Ile Ala Ala 
1               5                   10                  15      


Ser Gly Thr Asn Gln Ser Cys Pro Gly Phe Asp 
            20                  25          


<210>  35
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein PilE-fHBP

<400>  35

Ser Ala Val Thr Glu Tyr Tyr Leu Asn His Gly Glu Trp Pro Gly Asp 
1               5                   10                  15      


Asn Ser Ser Ala Gly Val Ala Thr Ser Ala Asp Ile Lys Gly Lys Tyr 
            20                  25                  30          


Val Gln Ser Val Thr Val Ala Asn Gly Val Ile Thr Ala Gln Met Ala 
        35                  40                  45              


Ser Ser Asn Val Asn Asn Glu Ile Lys Ser Lys Lys Leu Ser Leu Trp 
    50                  55                  60                  


Ala Lys Arg Gln Asn Gly Ser Val Lys Trp Phe Cys Gly Gln Pro Val 
65                  70                  75                  80  


Thr Arg Thr Thr Ala Thr Ala Thr Asp Val Ala Ala Ala Asn Gly Lys 
                85                  90                  95      


Thr Asp Asp Lys Ile Asn Thr Lys His Leu Pro Ser Thr Cys Arg Asp 
            100                 105                 110         


Asp Ser Ser Ala Ser Met Thr Arg Ser Lys Pro Val Asn Arg Thr Ala 
        115                 120                 125             


Phe Cys Cys Leu Ser Leu Thr Ala Ala Leu Ile Leu Thr Ala Cys Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Val Ala Ala Asp Ile Gly Ala Gly Leu Ala Asp 
145                 150                 155                 160 


Ala Leu Thr Ala Pro Leu Asp His Lys Asp Lys Ser Leu Gln Ser Leu 
                165                 170                 175     


Thr Leu Asp Gln Ser Val Arg Lys Asn Glu Lys Leu Lys Leu Ala Ala 
            180                 185                 190         


Gln Gly Ala Glu Lys Thr Tyr Gly Asn Gly Asp Ser Leu Asn Thr Gly 
        195                 200                 205             


Lys Leu Lys Asn Asp Lys Val Ser Arg Phe Asp Phe Ile Arg Gln Ile 
    210                 215                 220                 


Glu Val Asp Gly Gln Leu Ile Thr Leu Glu Ser Gly Glu Phe Gln Ile 
225                 230                 235                 240 


Tyr Lys Gln Asp His Ser Ala Val Val Ala Leu Gln Ile Glu Lys Ile 
                245                 250                 255     


Asn Asn Pro Asp Lys Ile Asp Ser Leu Ile Asn Gln Arg Ser Phe Leu 
            260                 265                 270         


Val Ser Gly Leu Gly Gly Glu His Thr Ala Phe Asn Gln Leu Pro Gly 
        275                 280                 285             


Gly Lys Ala Glu Tyr His Gly Lys Ala Phe Ser Ser Asp Asp Ala Gly 
    290                 295                 300                 


Gly Lys Leu Thr Tyr Thr Ile Asp Phe Ala Ala Lys Gln Gly His Gly 
305                 310                 315                 320 


Lys Ile Glu His Leu Lys Thr Pro Glu Gln Asn Val Glu Leu Ala Ala 
                325                 330                 335     


Ala Glu Leu Lys Ala Asp Glu Lys Ser His Ala Val Ile Leu Gly Asp 
            340                 345                 350         


Thr Arg Tyr Gly Ser Glu Glu Lys Gly Thr Tyr His Leu Ala Leu Phe 
        355                 360                 365             


Gly Asp Arg Ala Gln Glu Ile Ala Gly Ser Ala Thr Val Lys Ile Gly 
    370                 375                 380                 


Glu Lys Val His Glu Ile Gly Ile Ala Gly Lys Gln 
385                 390                 395     


<210>  36
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein PilE-fHBP

<400>  36

Cys Gly Gln Pro Val Thr Arg Thr Thr Ala Thr Ala Thr Asp Val Ala 
1               5                   10                  15      


Ala Ala Asn Gly Lys Thr Asp Asp Lys Ile Asn Thr Lys His Leu Pro 
            20                  25                  30          


Ser Thr Cys Met Thr Arg Ser Lys Pro Val Asn Arg Thr Ala Phe Cys 
        35                  40                  45              


Cys Leu Ser Leu Thr Ala Ala Leu Ile Leu Thr Ala Cys Ser Ser Gly 
    50                  55                  60                  


Gly Gly Gly Val Ala Ala Asp Ile Gly Ala Gly Leu Ala Asp Ala Leu 
65                  70                  75                  80  


Thr Ala Pro Leu Asp His Lys Asp Lys Ser Leu Gln Ser Leu Thr Leu 
                85                  90                  95      


Asp Gln Ser Val Arg Lys Asn Glu Lys Leu Lys Leu Ala Ala Gln Gly 
            100                 105                 110         


Ala Glu Lys Thr Tyr Gly Asn Gly Asp Ser Leu Asn Thr Gly Lys Leu 
        115                 120                 125             


Lys Asn Asp Lys Val Ser Arg Phe Asp Phe Ile Arg Gln Ile Glu Val 
    130                 135                 140                 


Asp Gly Gln Leu Ile Thr Leu Glu Ser Gly Glu Phe Gln Ile Tyr Lys 
145                 150                 155                 160 


Gln Asp His Ser Ala Val Val Ala Leu Gln Ile Glu Lys Ile Asn Asn 
                165                 170                 175     


Pro Asp Lys Ile Asp Ser Leu Ile Asn Gln Arg Ser Phe Leu Val Ser 
            180                 185                 190         


Gly Leu Gly Gly Glu His Thr Ala Phe Asn Gln Leu Pro Gly Gly Lys 
        195                 200                 205             


Ala Glu Tyr His Gly Lys Ala Phe Ser Ser Asp Asp Ala Gly Gly Lys 
    210                 215                 220                 


Leu Thr Tyr Thr Ile Asp Phe Ala Ala Lys Gln Gly His Gly Lys Ile 
225                 230                 235                 240 


Glu His Leu Lys Thr Pro Glu Gln Asn Val Glu Leu Ala Ala Ala Glu 
                245                 250                 255     


Leu Lys Ala Asp Glu Lys Ser His Ala Val Ile Leu Gly Asp Thr Arg 
            260                 265                 270         


Tyr Gly Ser Glu Glu Lys Gly Thr Tyr His Leu Ala Leu Phe Gly Asp 
        275                 280                 285             


Arg Ala Gln Glu Ile Ala Gly Ser Ala Thr Val Lys Ile Gly Glu Lys 
    290                 295                 300                 


Val His Glu Ile Gly Ile Ala Gly Lys Gln 
305                 310                 


<210>  37
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein PilV-fHBP

<400>  37

Thr Met Glu Arg Tyr Tyr Arg Gln Lys Gly Thr Phe Lys Thr Tyr Asp 
1               5                   10                  15      


Lys Asn Lys Leu Lys Gln Asn Lys Tyr Phe Asn Val Thr Leu Ser Lys 
            20                  25                  30          


Val Ser Pro Asp His Phe Thr Leu Gln Ala Asp Pro Asn Pro Thr Thr 
        35                  40                  45              


Asn Asp Gly Glu Thr Cys Val Val Thr Leu Asp Gly Gly Thr Ile Ala 
    50                  55                  60                  


Ala Ser Gly Thr Asn Gln Ser Cys Pro Gly Phe Asp Met Thr Arg Ser 
65                  70                  75                  80  


Lys Pro Val Asn Arg Thr Ala Phe Cys Cys Leu Ser Leu Thr Ala Ala 
                85                  90                  95      


Leu Ile Leu Thr Ala Cys Ser Ser Gly Gly Gly Gly Val Ala Ala Asp 
            100                 105                 110         


Ile Gly Ala Gly Leu Ala Asp Ala Leu Thr Ala Pro Leu Asp His Lys 
        115                 120                 125             


Asp Lys Ser Leu Gln Ser Leu Thr Leu Asp Gln Ser Val Arg Lys Asn 
    130                 135                 140                 


Glu Lys Leu Lys Leu Ala Ala Gln Gly Ala Glu Lys Thr Tyr Gly Asn 
145                 150                 155                 160 


Gly Asp Ser Leu Asn Thr Gly Lys Leu Lys Asn Asp Lys Val Ser Arg 
                165                 170                 175     


Phe Asp Phe Ile Arg Gln Ile Glu Val Asp Gly Gln Leu Ile Thr Leu 
            180                 185                 190         


Glu Ser Gly Glu Phe Gln Ile Tyr Lys Gln Asp His Ser Ala Val Val 
        195                 200                 205             


Ala Leu Gln Ile Glu Lys Ile Asn Asn Pro Asp Lys Ile Asp Ser Leu 
    210                 215                 220                 


Ile Asn Gln Arg Ser Phe Leu Val Ser Gly Leu Gly Gly Glu His Thr 
225                 230                 235                 240 


Ala Phe Asn Gln Leu Pro Gly Gly Lys Ala Glu Tyr His Gly Lys Ala 
                245                 250                 255     


Phe Ser Ser Asp Asp Ala Gly Gly Lys Leu Thr Tyr Thr Ile Asp Phe 
            260                 265                 270         


Ala Ala Lys Gln Gly His Gly Lys Ile Glu His Leu Lys Thr Pro Glu 
        275                 280                 285             


Gln Asn Val Glu Leu Ala Ala Ala Glu Leu Lys Ala Asp Glu Lys Ser 
    290                 295                 300                 


His Ala Val Ile Leu Gly Asp Thr Arg Tyr Gly Ser Glu Glu Lys Gly 
305                 310                 315                 320 


Thr Tyr His Leu Ala Leu Phe Gly Asp Arg Ala Gln Glu Ile Ala Gly 
                325                 330                 335     


Ser Ala Thr Val Lys Ile Gly Glu Lys Val His Glu Ile Gly Ile Ala 
            340                 345                 350         


Gly Lys Gln 
        355 


<210>  38
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein PilV-fHBP

<400>  38

Gly Glu Thr Cys Val Val Thr Leu Asn Asp Gly Gly Thr Ile Ala Ala 
1               5                   10                  15      


Ser Gly Thr Asn Gln Ser Cys Pro Gly Phe Asp Met Thr Arg Ser Lys 
            20                  25                  30          


Pro Val Asn Arg Thr Ala Phe Cys Cys Leu Ser Leu Thr Ala Ala Leu 
        35                  40                  45              


Ile Leu Thr Ala Cys Ser Ser Gly Gly Gly Gly Val Ala Ala Asp Ile 
    50                  55                  60                  


Gly Ala Gly Leu Ala Asp Ala Leu Thr Ala Pro Leu Asp His Lys Asp 
65                  70                  75                  80  


Lys Ser Leu Gln Ser Leu Thr Leu Asp Gln Ser Val Arg Lys Asn Glu 
                85                  90                  95      


Lys Leu Lys Leu Ala Ala Gln Gly Ala Glu Lys Thr Tyr Gly Asn Gly 
            100                 105                 110         


Asp Ser Leu Asn Thr Gly Lys Leu Lys Asn Asp Lys Val Ser Arg Phe 
        115                 120                 125             


Asp Phe Ile Arg Gln Ile Glu Val Asp Gly Gln Leu Ile Thr Leu Glu 
    130                 135                 140                 


Ser Gly Glu Phe Gln Ile Tyr Lys Gln Asp His Ser Ala Val Val Ala 
145                 150                 155                 160 


Leu Gln Ile Glu Lys Ile Asn Asn Pro Asp Lys Ile Asp Ser Leu Ile 
                165                 170                 175     


Asn Gln Arg Ser Phe Leu Val Ser Gly Leu Gly Gly Glu His Thr Ala 
            180                 185                 190         


Phe Asn Gln Leu Pro Gly Gly Lys Ala Glu Tyr His Gly Lys Ala Phe 
        195                 200                 205             


Ser Ser Asp Asp Ala Gly Gly Lys Leu Thr Tyr Thr Ile Asp Phe Ala 
    210                 215                 220                 


Ala Lys Gln Gly His Gly Lys Ile Glu His Leu Lys Thr Pro Glu Gln 
225                 230                 235                 240 


Asn Val Glu Leu Ala Ala Ala Glu Leu Lys Ala Asp Glu Lys Ser His 
                245                 250                 255     


Ala Val Ile Leu Gly Asp Thr Arg Tyr Gly Ser Glu Glu Lys Gly Thr 
            260                 265                 270         


Tyr His Leu Ala Leu Phe Gly Asp Arg Ala Gln Glu Ile Ala Gly Ser 
        275                 280                 285             


Ala Thr Val Lys Ile Gly Glu Lys Val His Glu Ile Gly Ile Ala Gly 
    290                 295                 300                 


Lys Gln 
305     


<210>  39
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Control siRNA

<400>  39
auguauuggc cuguauag                                                     18


