
                                SEQUENCE LISTING

<110> Mayo Foundation for Medical Education and Research

<120> MEASLES VIRUSES WITH REDUCED
  SUSCEPTIBILITY TO NEUTRALIZATION
  

<130> 07039-1146WO1

<150> US 61/674,815       
<151> 2012-07-20  

<160> 4

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1854
<212> DNA
<213> Measles virus

<400> 1
atgtcaccac aacgagaccg gataaatgcc ttctacaaag ataaccccca tcccaaggga 60
agtaggatag tcattaacag agaacatctt atgattgata gaccttatgt tttgctggct 120
gttctgtttg tcatgtttct gagcttgatc gggttgctag ccattgcagg aattcgactt 180
catcgggcag ccatctacac cgcagagatc cataaaagcc tcagcaccaa tctagatgta 240
actaactcaa tcgagcatca ggtcaaggac gtgctgacac cactcttcaa aatcatcggt 300
gatgaagtgg gcctgaggac acctcagaga ttcactgacc tagtgaaatt catctctgac 360
aagattaaat tccttaatcc ggatagggag tacgacttca gagatctcac ttggtgtatc 420
aacccgccag agagaatcaa attggattat gatcaatact gtgcagatgt ggctgctgaa 480
gagctcatga atgcattggt gaactcaact ctactggaga ccagaacaac caatcagttc 540
ctagctgtct caaagggaaa ctgctcaggg cccactacaa tcagaggtca attctcaaac 600
atgtcgctgt ccctgttaga cttgtattta ggtcgaggtt acaatgtgtc atctatagtc 660
actatgacat cccagggaat gtatggggga acttacctag tggaaaagcc taatctgagc 720
agcaaaaggt cagagttgtc acaactgagc atgtaccgag tgtttgaagt aggtgttatc 780
agaaatccgg gtttgggggc tccggtgttc catatgacaa actatcttga gcaaccagtc 840
agtaatgatc tcagcaactg tatggtggct ttgggggagc tcaaactcgc agccctttgt 900
cacggggaag attctatcac aattccctat cagggatcag ggaaaggtgt cagcttccag 960
ctcgtcaagc taggtgtctg gaaatcccca accgacatgc aatcctgggt ccccttatca 1020
acggatgatc cagtgataga caggctttac ctctcatctc acagaggtgt tatcgctgac 1080
aatcaagcaa aatgggctgt cccgacaaca cgaacagatg acaagttgcg aatggagaca 1140
tgcttccaac aggcgtgtaa gggtaaaatc caagcactct gcgagaatcc cgagtgggca 1200
ccattgaagg ataacaggat tccttcatac ggggtcttgt ctgttgatct gagtctgaca 1260
gttgagctta aaatcaaaat tgcttcggga ttcgggccat tgatcacaca cggttcaggg 1320
atggacctat acaaatccaa ccacaacaat gtgtattggc tgactatccc gccaatgaag 1380
aacctagcct taggtgtaat caacacattg gagtggatac cgagattcaa ggttagtccc 1440
tacctcttca atgtcccaat taaggaagca ggcgaagact gccatgcccc aacataccta 1500
cctgcggagg tggatggtga tgtcaaactc agttccaatc tggtgattct acctggtcaa 1560
gatctccaat atgttttggc aacctacgat acttccaggg ttgaacatgc tgtggtttat 1620
tacgtttaca gcccaagccg ctcattttct tacttttatc cttttaggtt gcctataaag 1680
ggggtcccca tcgaattaca agtggaatgc ttcacatggg accaaaaact ctggtgccgt 1740
cacttctgtg tgcttgcgga ctcagaatct ggtggacata tcactcactc tgggatggag 1800
ggcatgggag tcagctgcac agtcacccgg gaagatggaa ccaatcgcag atag       1854

<210> 2
<211> 597
<212> PRT
<213> Measles virus

<400> 2
Met Ser Pro Gln Arg Asp Arg Ile Asn Ala Phe Tyr Lys Asp Asn Pro
 1               5                  10                  15      
His Pro Lys Gly Ser Arg Ile Val Ile Asn Arg Glu His Leu Met Ile
            20                  25                  30          
Asp Arg Pro Tyr Val Leu Leu Ala Val Leu Phe Val Met Phe Leu Ser
        35                  40                  45              
Leu Ile Gly Leu Leu Ala Ile Ala Gly Ile Arg Leu His Arg Ala Ala
    50                  55                  60                  
Ile Tyr Thr Ala Glu Ile His Lys Ser Leu Ser Thr Asn Leu Asp Val
65                  70                  75                  80  
Thr Asn Ser Ile Glu His Gln Val Lys Asp Val Leu Thr Pro Leu Phe
                85                  90                  95      
Lys Ile Ile Gly Asp Glu Val Gly Leu Arg Thr Pro Gln Arg Phe Thr
            100                 105                 110         
Asp Leu Val Lys Phe Ile Ser Asp Lys Ile Lys Phe Leu Asn Pro Asp
        115                 120                 125             
Arg Glu Tyr Asp Phe Arg Asp Leu Thr Trp Cys Ile Asn Pro Pro Glu
    130                 135                 140                 
Arg Ile Lys Leu Asp Tyr Asp Gln Tyr Cys Ala Asp Val Ala Ala Glu
145                 150                 155                 160 
Glu Leu Met Asn Ala Leu Val Asn Ser Thr Leu Leu Glu Thr Arg Thr
                165                 170                 175     
Thr Asn Gln Phe Leu Ala Val Ser Lys Gly Asn Cys Ser Gly Pro Thr
            180                 185                 190         
Thr Ile Arg Gly Gln Phe Ser Asn Met Ser Leu Ser Leu Leu Asp Leu
        195                 200                 205             
Tyr Leu Gly Arg Gly Tyr Asn Val Ser Ser Ile Val Thr Met Thr Ser
    210                 215                 220                 
Gln Gly Met Tyr Gly Gly Thr Tyr Leu Val Glu Lys Pro Asn Leu Ser
225                 230                 235                 240 
Ser Lys Arg Ser Glu Leu Ser Gln Leu Ser Met Tyr Arg Val Phe Glu
                245                 250                 255     
Val Gly Val Ile Arg Asn Pro Gly Leu Gly Ala Pro Val Phe His Met
            260                 265                 270         
Thr Asn Tyr Leu Glu Gln Pro Val Ser Asn Asp Leu Ser Asn Cys Met
        275                 280                 285             
Val Ala Leu Gly Glu Leu Lys Leu Ala Ala Leu Cys Leu Val Lys Leu
    290                 295                 300                 
Gly Val Trp Lys Ser Pro Thr Asp Met Gln Ser Trp Val Pro Leu Ser
305                 310                 315                 320 
Thr Asp Asp Pro Val Ile Asp Arg Leu Tyr Leu Ser Ser His Arg Gly
                325                 330                 335     
Val Ile Ala Asp Asn Gln Ala Lys Trp Ala Val Pro Thr Thr Arg Thr
            340                 345                 350         
Asp Asp Lys Leu Arg Met Glu Thr Cys Phe Gln Gln Ala Cys Lys Gly
        355                 360                 365             
Lys Ile Gln Ala Leu Cys Glu Asn Pro Glu Trp Ala Pro Leu Lys Asp
    370                 375                 380                 
Asn Arg Ile Pro Ser Tyr Gly Val Leu Ser Val Asp Leu Ser Leu Thr
385                 390                 395                 400 
Val Glu Leu Lys Ile Lys Ile Ala Ser Gly Phe Gly Pro Leu Ile Thr
                405                 410                 415     
His Gly Ser Gly Met Asp Leu Tyr Lys Ser Asn His Asn Asn Val Tyr
            420                 425                 430         
Trp Leu Thr Ile Pro Pro Met Lys Asn Leu Ala Leu Gly Val Ile Asn
        435                 440                 445             
Thr Leu Glu Trp Ile Pro Arg Phe Lys Val Ser Pro Tyr Leu Phe Asn
    450                 455                 460                 
Val Pro Ile Lys Glu Ala Gly Glu Asp Cys His Ala Pro Thr Tyr Leu
465                 470                 475                 480 
Pro Ala Glu Val Asp Gly Asp Val Lys Leu Ser Ser Asn Leu Val Ile
                485                 490                 495     
Leu Pro Gly Gln Asp Leu Gln Tyr Val Leu Ala Thr Tyr Asp Thr Ser
            500                 505                 510         
Arg Val Glu His Ala Val Val Tyr Tyr Val Tyr Ser Pro Ser Arg Ser
        515                 520                 525             
Phe Ser Tyr Phe Tyr Pro Phe Arg Leu Pro Ile Lys Gly Val Pro Ile
    530                 535                 540                 
Glu Leu Gln Val Glu Cys Phe Thr Trp Asp Gln Lys Leu Trp Cys Arg
545                 550                 555                 560 
His Phe Cys Val Leu Ala Asp Ser Glu Ser Gly Gly His Ile Thr His
                565                 570                 575     
Ser Gly Met Glu Gly Met Gly Val Ser Cys Thr Val Thr Arg Glu Asp
            580                 585                 590         
Gly Thr Asn Arg Arg
        595         


<210> 3
<211> 1854
<212> DNA
<213> Measles virus

<400> 3
atgtcaccac aacgagaccg gataaatgcc ttctacaaag ataaccccca tcccaaggga 60
agtaggatag tcattaacag agaacatctt atgattgata gaccttatgt tttgctggct 120
gttctgtttg tcatgtttct gagcttgatc gggttgctag ccattgcagg aattcgactt 180
catcgggcag ccatctacac cgcagagatc cataaaagcc tcagcaccaa tctagatgta 240
actaactcaa tcgagcatca ggtcaaggac gtgctgacac cactcttcaa aatcatcggt 300
gatgaagtgg gcctgaggac acctcagaga ttcactgacc tagtgaaatt catctctgac 360
aagattaaat tccttaatcc ggatagggag tacgacttca gagatctcac ttggtgtatc 420
aacccgccag agagaatcaa attggattat gatcaatact gtgcagatgt ggctgctgaa 480
gagctcatga atgcattggt gaactcaact ctactggaga ccagaacaac caatcagttc 540
ctagctgtct caaagggaaa ctgctcaggg cccactacaa tcagaggtca attctcaaac 600
atgtcgctgt ccctgttaga cttgtattta ggtcgaggtt acaatgtgtc atctatagtc 660
actatgacat cccagggaat gtatggggga acttacctag tggaaaagcc taatctgagc 720
agcaaaaggt cagagttgtc acaactgagc atgtaccgag tgtttgaagt aggtgttatc 780
agaaatccgg gtttgggggc tccggtgttc catatgacaa actatcttga gcaaccagtc 840
agtaatgatc tcagcaactg tatggtggct ttgggggagc tcaaactcgc agccctttgt 900
cacggggaag attctatcac aattccctat cagggatcag ggaaaggtgt cagcttccag 960
ctcgtcaagc taggtgtctg gaaatcccca accgacatgc aatcctgggt ccccttatca 1020
acggatgatc cagtgataga caggctttac ctctcatctc acagaggtgt tatcgctgac 1080
aaccaagcaa aatgggctgt cccgacaaca cgaacagatg acaagttgcg aatggagaca 1140
tgcttccaac aggcgtgtaa gggtaaaatc caagcactct gcgagaatcc cgagtgggca 1200
ccattgaagg ataacaggat tccttcatac ggggtcttgt ctgttgatct gagtctgaca 1260
gttgagctta aaatcaaaat tgcttcggga ttcgggccat tgatcacaca cggttcaggg 1320
atggacctat acaaatccaa ccacaacaat gtgtattggc tgactatccc gccaatgaag 1380
aacctagcct taggtgtaat caacacattg gagtggatac cgagattcaa ggttagtccc 1440
tacctcttca ctgtcccaat taaggaagca ggcggagact gccatgcccc aacataccta 1500
cctgcggagg tggatggtga tgtcaaactc agttccaatc tggtgattct acctggtcaa 1560
gatctccaat atgttttggc aacctacgat acttccaggg ttgaacatgc tgtggtttat 1620
tacgtttaca gcccaagccg ctcattttct tacttttatc cttttaggtt gcctataaag 1680
ggggtcccca tcgaattaca agtggaatgc ttcacatggg accaaaaact ctggtgccgt 1740
cacttctgtg tgcttgcgga ctcagaatct ggtggacata tcactcactc tgggatggtg 1800
ggcatgggag tcagctgcac agtcacccgg gaagatggaa ccaatcgcag atag       1854

<210> 4
<211> 614
<212> PRT
<213> Measles virus

<400> 4
Met Ser Pro Gln Arg Asp Arg Ile Asn Ala Phe Tyr Lys Asp Asn Pro
 1               5                  10                  15      
His Pro Lys Gly Ser Arg Ile Val Ile Asn Arg Glu His Leu Met Ile
            20                  25                  30          
Asp Arg Pro Tyr Val Leu Leu Ala Val Leu Phe Val Met Phe Leu Ser
        35                  40                  45              
Leu Ile Gly Leu Leu Ala Ile Ala Gly Ile Arg Leu His Arg Ala Ala
    50                  55                  60                  
Ile Tyr Thr Ala Glu Ile His Lys Ser Leu Ser Thr Asn Leu Asp Val
65                  70                  75                  80  
Thr Asn Ser Ile Glu His Gln Val Lys Asp Val Leu Thr Pro Leu Phe
                85                  90                  95      
Lys Ile Ile Gly Asp Glu Val Gly Leu Arg Thr Pro Gln Arg Phe Thr
            100                 105                 110         
Asp Leu Val Lys Phe Ile Ser Asp Lys Ile Lys Phe Leu Asn Pro Asp
        115                 120                 125             
Arg Glu Tyr Asp Phe Arg Asp Leu Thr Trp Cys Ile Asn Pro Pro Glu
    130                 135                 140                 
Arg Ile Lys Leu Asp Tyr Asp Gln Tyr Cys Ala Asp Val Ala Ala Glu
145                 150                 155                 160 
Glu Leu Met Asn Ala Leu Val Asn Ser Thr Leu Leu Glu Thr Arg Thr
                165                 170                 175     
Thr Asn Gln Phe Leu Ala Val Ser Lys Gly Asn Cys Ser Gly Pro Thr
            180                 185                 190         
Thr Ile Arg Gly Gln Phe Ser Asn Met Ser Leu Ser Leu Leu Asp Leu
        195                 200                 205             
Tyr Leu Gly Arg Gly Tyr Asn Val Ser Ser Ile Val Thr Met Thr Ser
    210                 215                 220                 
Gln Gly Met Tyr Gly Gly Thr Tyr Leu Val Glu Lys Pro Asn Leu Ser
225                 230                 235                 240 
Ser Lys Arg Ser Glu Leu Ser Gln Leu Ser Met Tyr Arg Val Phe Glu
                245                 250                 255     
Val Gly Val Ile Arg Asn Pro Gly Leu Gly Ala Pro Val Phe His Met
            260                 265                 270         
Thr Asn Tyr Leu Glu Gln Pro Ser Asn Asp Leu Ser Asn Cys Met Val
        275                 280                 285             
Ala Leu Gly Glu Leu Lys Leu Ala Ala Leu Cys His Gly Glu Asp Ser
    290                 295                 300                 
Ile Thr Ile Pro Tyr Gln Gly Ser Gly Lys Gly Val Ser Phe Gln Leu
305                 310                 315                 320 
Val Lys Leu Gly Val Trp Lys Ser Pro Thr Asp Met Gln Ser Trp Val
                325                 330                 335     
Pro Leu Ser Thr Asp Asp Pro Val Ile Asp Arg Leu Tyr Leu Ser Ser
            340                 345                 350         
His Arg Gly Val Ile Ala Asp Asn Gln Ala Lys Trp Ala Val Pro Thr
        355                 360                 365             
Thr Arg Thr Asp Asp Lys Leu Arg Met Glu Thr Cys Phe Gln Gln Ala
    370                 375                 380                 
Cys Lys Gly Lys Ile Gln Ala Leu Cys Glu Asn Pro Glu Trp Ala Pro
385                 390                 395                 400 
Leu Lys Asp Asn Arg Ile Pro Ser Tyr Gly Val Leu Ser Val Asp Leu
                405                 410                 415     
Ser Leu Thr Val Glu Leu Lys Ile Lys Ile Ala Ser Gly Phe Gly Pro
            420                 425                 430         
Leu Ile Thr His Gly Ser Gly Met Asp Leu Tyr Lys Ser Asn His Asn
        435                 440                 445             
Asn Val Tyr Trp Leu Thr Ile Pro Pro Met Asn Leu Ala Leu Gly Val
    450                 455                 460                 
Ile Asn Thr Leu Glu Trp Ile Pro Arg Phe Lys Val Ser Pro Tyr Leu
465                 470                 475                 480 
Phe Thr Val Pro Ile Lys Glu Ala Gly Gly Asp Cys His Ala Pro Thr
                485                 490                 495     
Tyr Leu Pro Ala Glu Val Asp Gly Asp Val Lys Leu Ser Ser Asn Leu
            500                 505                 510         
Val Ile Leu Pro Gly Asp Leu Gln Tyr Val Leu Ala Thr Tyr Asp Thr
        515                 520                 525             
Ser Arg Val Glu His Ala Val Val Tyr Tyr Val Tyr Ser Pro Ser Arg
    530                 535                 540                 
Ser Phe Ser Tyr Phe Tyr Pro Phe Arg Leu Pro Ile Lys Gly Val Pro
545                 550                 555                 560 
Ile Glu Leu Gln Val Glu Cys Phe Thr Trp Asp Gln Lys Leu Trp Cys
                565                 570                 575     
Arg His Phe Cys Val Leu Ala Asp Ser Glu Ser Gly Gly His Ile Thr
            580                 585                 590         
His Ser Gly Met Val Gly Met Gly Val Ser Cys Thr Val Thr Arg Glu
        595                 600                 605             
Asp Gly Thr Asn Arg Arg
    610                 

