                         SEQUENCE LISTING

<110>  Kaplan, Daniel  D
       Saberi, Maziyar
 
<120>  METHODS OF TREATING GLUCOSE METABOLISM DISORDERS

<130>  NGMB-0129WO

<150>  US 61/672,690
<151>  2012-07-17

<160>  74    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  1

Lys Asp Thr Thr Val Lys Ser Gly Ala 
1               5                   


<210>  2
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  2

Val Phe Ala Glu His Lys Glu Ile Gln Lys Leu Ala Glu Gln Phe Val 
1               5                   10                  15      


Leu Leu Asn Leu Val Tyr Glu Thr Thr Asp 
            20                  25      


<210>  3
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  3

His Leu Ser Pro Asp Gly Gln Tyr Val Pro 
1               5                   10  


<210>  4
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  4

Ile Val Phe Val Asp Pro Ser Leu Thr Val Arg Ala Asp Ile Thr Gly 
1               5                   10                  15      


<210>  5
<211>  15
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is modified to comprise a CONH2 group instead of a carboxyl 
       group.

<400>  5

Ile Val Phe Val Asp Pro Ser Leu Thr Val Arg Ala Asp Ile Thr 
1               5                   10                  15  


<210>  6
<211>  16
<212>  PRT
<213>  Canis lupus familiaris

<400>  6

Leu Tyr Ala Tyr Glu Pro Ser Asp Thr Ala Leu Leu Tyr Asp Asn Met 
1               5                   10                  15      


<210>  7
<211>  20
<212>  PRT
<213>  Pan troglodytes

<400>  7

Tyr Ser Asn Arg Leu Tyr Ala Tyr Glu Pro Ser Asp Thr Ala Leu Leu 
1               5                   10                  15      


Tyr Asp Asn Met 
            20  


<210>  8
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Lys Ile Pro Val Ser Ala Phe Leu Leu Leu Val Ala Leu Ser 
1               5                   10                  15      


Tyr Thr Leu Ala Arg Asp Thr Thr Val Lys Pro Gly Ala Lys Lys Asp 
            20                  25                  30          


Thr Lys Asp Ser Arg Pro Lys Leu Pro Gln Thr Leu Ser Arg Gly Trp 
        35                  40                  45              


Gly Asp Gln Leu Ile Trp Thr Gln Thr Tyr Glu Glu Ala Leu Tyr Lys 
    50                  55                  60                  


Ser Lys Thr Ser Asn Lys Pro Leu Met Ile Ile His His Leu Asp Glu 
65                  70                  75                  80  


Cys Pro His Ser Gln Ala Leu Lys Lys Val Phe Ala Glu Asn Lys Glu 
                85                  90                  95      


Ile Gln Lys Leu Ala Glu Gln Phe Val Leu Leu Asn Leu Val Tyr Glu 
            100                 105                 110         


Thr Thr Asp Lys His Leu Ser Pro Asp Gly Gln Tyr Val Pro Arg Ile 
        115                 120                 125             


Met Phe Val Asp Pro Ser Leu Thr Val Arg Ala Asp Ile Thr Gly Arg 
    130                 135                 140                 


Tyr Ser Asn Arg Leu Tyr Ala Tyr Glu Pro Ala Asp Thr Ala Leu Leu 
145                 150                 155                 160 


Leu Asp Asn Met Lys Lys Ala Leu Lys Leu Leu Lys Thr Glu Leu 
                165                 170                 175 


<210>  9
<211>  996
<212>  DNA
<213>  Homo sapiens

<400>  9
aatcacttgg ggaaaggaag gttcgtttct gagttagcaa caagtaaatg cagcactagt       60

gggtgggatt gaggtatgcc ctggtgcata aatagagact cagctgtgct ggcacactca      120

gaagcttgga ccgcatccta gccgccgact cacacaaggc aggtgggtga ggaaatccag      180

agttgccatg gagaaaattc cagtgtcagc attcttgctc cttgtggccc tctcctacac      240

tctggccaga gataccacag tcaaacctgg agccaaaaag gacacaaagg actctcgacc      300

caaactgccc cagaccctct ccagaggttg gggtgaccaa ctcatctgga ctcagacata      360

tgaagaagct ctatataaat ccaagacaag caacaaaccc ttgatgatta ttcatcactt      420

ggatgagtgc ccacacagtc aagctttaaa gaaagtgttt gctgaaaata aagaaatcca      480

gaaattggca gagcagtttg tcctcctcaa tctggtttat gaaacaactg acaaacacct      540

ttctcctgat ggccagtatg tccccaggat tatgtttgtt gacccatctc tgacagttag      600

agccgatatc actggaagat attcaaatcg tctctatgct tacgaacctg cagatacagc      660

tctgttgctt gacaacatga agaaagctct caagttgctg aagactgaat tgtaaagaaa      720

aaaaatctcc aagcccttct gtctgtcagg ccttgagact tgaaaccaga agaagtgtga      780

gaagactggc tagtgtggaa gcatagtgaa cacactgatt aggttatggt ttaatgttac      840

aacaactatt ttttaagaaa aacaagtttt agaaatttgg tttcaagtgt acatgtgtga      900

aaacaatatt gtatactacc atagtgagcc atgattttct aaaaaaaaaa ataaatgttt      960

tgggggtgtt ctgttttctc caaaaaaaaa aaaaaa                                996


<210>  10
<211>  175
<212>  PRT
<213>  Mus musculus

<400>  10

Met Glu Lys Phe Ser Val Ser Ala Ile Leu Leu Leu Val Ala Ile Ser 
1               5                   10                  15      


Gly Thr Leu Ala Lys Asp Thr Thr Val Lys Ser Gly Ala Lys Lys Asp 
            20                  25                  30          


Pro Lys Asp Ser Arg Pro Lys Leu Pro Gln Thr Leu Ser Arg Gly Trp 
        35                  40                  45              


Gly Asp Gln Leu Ile Trp Thr Gln Thr Tyr Glu Glu Ala Leu Tyr Arg 
    50                  55                  60                  


Ser Lys Thr Ser Asn Arg Pro Leu Met Val Ile His His Leu Asp Glu 
65                  70                  75                  80  


Cys Pro His Ser Gln Ala Leu Lys Lys Val Phe Ala Glu His Lys Glu 
                85                  90                  95      


Ile Gln Lys Leu Ala Glu Gln Phe Val Leu Leu Asn Leu Val Tyr Glu 
            100                 105                 110         


Thr Thr Asp Lys His Leu Ser Pro Asp Gly Gln Tyr Val Pro Arg Ile 
        115                 120                 125             


Val Phe Val Asp Pro Ser Leu Thr Val Arg Ala Asp Ile Thr Gly Arg 
    130                 135                 140                 


Tyr Ser Asn Arg Leu Tyr Ala Tyr Glu Pro Ser Asp Thr Ala Leu Leu 
145                 150                 155                 160 


Tyr Asp Asn Met Lys Lys Ala Leu Lys Leu Leu Lys Thr Glu Leu 
                165                 170                 175 


<210>  11
<211>  760
<212>  DNA
<213>  Mus musculus

<400>  11
ggcaaccctt gcggctcaca caaagcagga gggtgggaag cccagatttg ccatggagaa       60

attttcagtg tctgcaatcc tgcttcttgt ggccatttct ggtaccttgg ccaaagacac      120

cacagtcaaa tctggagcca aaaaggaccc aaaggactct cggcccaaac tacctcagac      180

actctccaga ggttggggcg atcagctcat ctggactcag acatacgaag aagctttata      240

cagatccaag acaagcaaca gacccttgat ggtcattcat cacttggacg aatgcccaca      300

cagtcaagcc ttaaagaaag tgtttgctga acataaagaa atccagaaat tggcagagca      360

gtttgttctc ctcaacctgg tctatgaaac aactgacaag cacctttctc ctgatggcca      420

gtatgtcccc agaattgtgt ttgtagaccc atccctgacg gtgagggcag acatcactgg      480

acgatactca aaccggctct acgcttatga accttctgac acagctctgt tgtacgacaa      540

catgaagaaa gctctcaagc tgctaaagac agaattgtag agccaactgc gcaccgggtc      600

aggagaccag aaggcagaag cactgtggac ttgcagatta cagtacagtt taatgttaca      660

acagatatat tttttaaaca cccacaggtg gggaaacaat attattatct actacagtga      720

agcatgattt tctagaaaat aaagtcttgt gagaactcca                            760


<210>  12
<211>  175
<212>  PRT
<213>  Macaca mulatta

<400>  12

Met Glu Lys Ile Ser Val Ser Ala Phe Leu Leu Leu Val Ala Leu Ser 
1               5                   10                  15      


Tyr Thr Leu Ala Arg Asp Thr Thr Val Lys Pro Gly Ala Lys Lys Asp 
            20                  25                  30          


Thr Lys Asp Ser Arg Pro Lys Leu Pro Gln Thr Leu Ser Arg Gly Trp 
        35                  40                  45              


Gly Asp Gln Leu Ile Trp Thr Gln Thr Tyr Glu Glu Ala Leu Tyr Lys 
    50                  55                  60                  


Ser Lys Thr Ser Asn Lys Pro Leu Met Ile Ile His His Leu Asp Glu 
65                  70                  75                  80  


Cys Pro His Ser Gln Ala Leu Lys Lys Val Phe Ala Glu Asn Lys Glu 
                85                  90                  95      


Ile Gln Lys Leu Ala Glu Gln Phe Val Leu Leu Asn Leu Val Tyr Glu 
            100                 105                 110         


Thr Thr Asp Lys His Leu Ser Pro Asp Gly Gln Tyr Val Pro Arg Ile 
        115                 120                 125             


Leu Phe Val Asp Pro Ser Leu Thr Val Arg Ala Asp Ile Thr Gly Arg 
    130                 135                 140                 


Tyr Ser Asn Arg Leu Tyr Ala Tyr Glu Pro Ala Asp Thr Ala Leu Leu 
145                 150                 155                 160 


Leu Asp Asn Met Lys Lys Ala Leu Lys Leu Leu Lys Thr Glu Leu 
                165                 170                 175 


<210>  13
<211>  193
<212>  PRT
<213>  Canis lupus familiaris

<400>  13

Glu Ser Tyr Met Asp Thr Asn Phe Gln Lys Phe Lys Ile Ile Arg Phe 
1               5                   10                  15      


Ala Met Glu Lys Ile Ser Val Ser Ala Phe Leu Leu Leu Val Ala Leu 
            20                  25                  30          


Ser Tyr Thr Leu Ala Lys Asp Ile Thr Val Lys Ser Gly Ala Lys Lys 
        35                  40                  45              


Asp Thr Lys Asp Ser Ala Pro Lys Leu Pro Gln Thr Leu Ser Arg Gly 
    50                  55                  60                  


Trp Gly Asp Gln Leu Ile Trp Thr Gln Thr Tyr Glu Glu Ala Leu Tyr 
65                  70                  75                  80  


Lys Ser Lys Thr Ser Asn Lys Pro Leu Met Ile Ile His His Leu Asp 
                85                  90                  95      


Glu Cys Pro His Ser Gln Ala Leu Lys Lys Val Phe Ala Glu Asn Lys 
            100                 105                 110         


Glu Ile Gln Lys Leu Ala Glu Gln Phe Val Leu Leu Asn Leu Val Tyr 
        115                 120                 125             


Glu Thr Thr Asp Lys His Leu Ser Pro Asp Gly Gln Tyr Val Pro Arg 
    130                 135                 140                 


Ile Ile Phe Val Val Asp Pro Ser Leu Thr Val Arg Ala Asp Ile Thr 
145                 150                 155                 160 


Gly Arg Tyr Ser Asn Arg Leu Tyr Ala Tyr Glu Pro Ser Asp Ile Ala 
                165                 170                 175     


Leu Leu Leu Asp Asn Met Lys Lys Ala Leu Lys Leu Leu Lys Thr Glu 
            180                 185                 190         


Leu 
    


<210>  14
<211>  175
<212>  PRT
<213>  Rattus norvegicus

<400>  14

Met Glu Lys Phe Ser Val Ser Ala Ile Leu Leu Leu Val Ala Ile Ser 
1               5                   10                  15      


Gly Thr Leu Ala Lys Asp Thr Thr Val Lys Ser Gly Ser Lys Lys Asp 
            20                  25                  30          


Pro Lys Asp Ser Arg Pro Lys Leu Pro Gln Thr Leu Ser Arg Gly Trp 
        35                  40                  45              


Gly Asp Gln Leu Ile Trp Thr Gln Thr Tyr Glu Glu Ala Leu Tyr Lys 
    50                  55                  60                  


Ser Lys Thr Ser Asn Arg Pro Leu Met Val Ile His His Leu Asp Glu 
65                  70                  75                  80  


Cys Pro His Ser Gln Ala Leu Lys Lys Val Phe Ala Glu Asn Lys Glu 
                85                  90                  95      


Ile Gln Lys Leu Ala Glu Gln Phe Val Leu Leu Asn Leu Ile Tyr Glu 
            100                 105                 110         


Thr Thr Asp Lys His Leu Ser Pro Asp Gly Gln Tyr Val Pro Arg Ile 
        115                 120                 125             


Val Phe Val Asp Pro Ser Leu Thr Val Arg Ala Asp Ile Thr Gly Arg 
    130                 135                 140                 


Tyr Ser Asn Arg Leu Tyr Ala Tyr Glu Pro Ser Asp Thr Ala Leu Leu 
145                 150                 155                 160 


His Asp Asn Met Lys Lys Ala Leu Lys Leu Leu Lys Thr Glu Leu 
                165                 170                 175 


<210>  15
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gly Pro Val Arg Leu Gly Ile Leu Leu Phe Leu Phe Leu Ala Val 
1               5                   10                  15      


His Glu Ala Trp Ala Gly Met Leu Lys Glu Glu Asp Asp Asp Thr Glu 
            20                  25                  30          


Arg Leu Pro Ser Lys Cys Glu Val Cys Lys Leu Leu Ser Thr Glu Leu 
        35                  40                  45              


Gln Ala Glu Leu Ser Arg Thr Gly Arg Ser Arg Glu Val Leu Glu Leu 
    50                  55                  60                  


Gly Gln Val Leu Asp Thr Gly Lys Arg Lys Arg His Val Pro Tyr Ser 
65                  70                  75                  80  


Val Ser Glu Thr Arg Leu Glu Glu Ala Leu Glu Asn Leu Cys Glu Arg 
                85                  90                  95      


Ile Leu Asp Tyr Ser Val His Ala Glu Arg Lys Gly Ser Leu Arg Tyr 
            100                 105                 110         


Ala Lys Gly Gln Ser Gln Thr Met Ala Thr Leu Lys Gly Leu Val Gln 
        115                 120                 125             


Lys Gly Val Lys Val Asp Leu Gly Ile Pro Leu Glu Leu Trp Asp Glu 
    130                 135                 140                 


Pro Ser Val Glu Val Thr Tyr Leu Lys Lys Gln Cys Glu Thr Met Leu 
145                 150                 155                 160 


Glu Glu Phe Glu Asp Ile Val Gly Asp Trp Tyr Phe His His Gln Glu 
                165                 170                 175     


Gln Pro Leu Gln Asn Phe Leu Cys Glu Gly His Val Leu Pro Ala Ala 
            180                 185                 190         


Glu Thr Ala Cys Leu Gln Glu Thr Trp Thr Gly Lys Glu Ile Thr Asp 
        195                 200                 205             


Gly Glu Glu Lys Thr Glu Gly Glu Glu Glu Gln Glu Glu Glu Glu Glu 
    210                 215                 220                 


Glu Glu Glu Glu Glu Gly Gly Asp Lys Met Thr Lys Thr Gly Ser His 
225                 230                 235                 240 


Pro Lys Leu Asp Arg Glu Asp Leu 
                245             


<210>  16
<211>  1547
<212>  DNA
<213>  Homo sapiens

<400>  16
gctggattta aggttgccgc tagccgcctg ggaatttaag ggacccacac taccttcccg       60

aagttgaagg caagcggtga ttgtttgtag acggcgcttt gtcatgggac ctgtgcggtt      120

gggaatattg cttttccttt ttttggccgt gcacgaggct tgggctggga tgttgaagga      180

ggaggacgat gacacagaac gcttgcccag caaatgcgaa gtgtgtaagc tgctgagcac      240

agagctacag gcggaactga gtcgcaccgg tcgatctcga gaggtgctgg agctggggca      300

ggtgctggat acaggcaaga ggaagagaca cgtgccttac agcgtttcag agacaaggct      360

ggaagaggcc ttagagaatt tatgtgagcg gatcctggac tatagtgttc acgctgagcg      420

caagggctca ctgagatatg ccaagggtca gagtcagacc atggcaacac tgaaaggcct      480

agtgcagaag ggggtgaagg tggatctggg gatccctctg gagctttggg atgagcccag      540

cgtggaggtc acatacctca agaagcagtg tgagaccatg ttggaggagt ttgaagacat      600

tgtgggagac tggtacttcc accatcagga gcagccccta caaaattttc tctgtgaagg      660

tcatgtgctc ccagctgctg aaactgcatg tctacaggaa acttggactg gaaaggagat      720

cacagatggg gaagagaaaa cagaagggga ggaagagcag gaggaggagg aggaagagga      780

ggaagaggaa gggggagaca agatgaccaa gacaggaagc caccccaaac ttgaccgaga      840

agatctttga cccttgcctt tgagccccca ggaggggaag ggatcatgga gagccctcta      900

aagcctgcac tctccctgct ccacagcttt cagggtgtgt ttatgagtga ctccacccaa      960

gcttgtagct gttctctccc atctaacctc aggcaagatc ctggtgaaac agcatgacat     1020

ggcttctggg gtggagggtg ggggtggagg tcctgctcct agagatgaac tctatccagc     1080

cccttaattg gcaggtgtat gtgctgacag tactgaaagc tttcctcttt aactgatccc     1140

acccccaccc aaaagtcagc agtggcactg gagctgtggg ctttggggaa gtcacttagc     1200

tccttaaggt ctgtttttag acccttccaa ggaagaggcc agaacggaca ttctctgcga     1260

tctatataca ttgcctgtat ccaggaggct acacaccagc aaaccgtgaa ggagaatggg     1320

acactgggtc atggcctgga gttgctgata atttaggtgg gatagatact tggtctactt     1380

aagctcaatg taacccagag cccaccatat agttttatag gtgctcaatt ttctatatcg     1440

ctattaaact tttttctttt tttctaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                   1547


<210>  17
<211>  245
<212>  PRT
<213>  Mus musculus

<400>  17

Met Cys Gly Leu Arg Phe Ile Met Gly Pro Val Arg Leu Glu Ile Leu 
1               5                   10                  15      


Leu Phe Ile Leu Ala Ala Tyr Gly Ala Trp Ala Glu Ala Thr Lys Glu 
            20                  25                  30          


Glu Glu Asp Asp Thr Glu Arg Leu Pro Ser Lys Cys Glu Val Cys Lys 
        35                  40                  45              


Leu Leu Ser Met Glu Leu Gln Glu Ala Leu Ser Arg Thr Gly Arg Ser 
    50                  55                  60                  


Arg Glu Val Leu Glu Leu Gly Gln Val Leu Asp Thr Gly Lys Arg Lys 
65                  70                  75                  80  


Arg His Val Pro Tyr Ser Leu Ser Glu Thr Arg Leu Glu Glu Ala Leu 
                85                  90                  95      


Glu Asn Leu Cys Glu Arg Ile Leu Asp Tyr Asn Val His Ala Glu Arg 
            100                 105                 110         


Lys Gly Ser Leu Arg Tyr Ala Lys Gly Gln Ser Gln Thr Met Ala Thr 
        115                 120                 125             


Leu Lys Gly Leu Val Gln Lys Gly Val Lys Val Asp Leu Gly Ile Pro 
    130                 135                 140                 


Leu Glu Leu Trp Asp Glu Pro Ser Val Glu Val Thr Phe Leu Lys Lys 
145                 150                 155                 160 


Gln Cys Glu Thr Met Leu Glu Glu Phe Glu Asp Val Val Gly Asp Trp 
                165                 170                 175     


Tyr Phe His His Gln Glu Gln Pro Leu Gln His Phe Leu Cys Glu Arg 
            180                 185                 190         


His Val Leu Pro Ala Ser Glu Thr Ala Cys Leu Arg Glu Ala Trp Thr 
        195                 200                 205             


Gly Lys Glu Lys Ile Ser Asp Gly Gln Glu Glu Ala Asp Asp Glu Glu 
    210                 215                 220                 


Glu Glu Glu Glu Glu Glu Ile Thr Lys Thr Ser Gly Asn Pro Lys His 
225                 230                 235                 240 


Asp Pro Glu Asp Leu 
                245 


<210>  18
<211>  1781
<212>  DNA
<213>  Mus musculus

<400>  18
aaagggcccg ctgccttcca gaagttggtc tgaaggcaaa gggtggttgt atgtgtggac       60

tgcgttttat catgggacct gtgcggctgg agatactgct tttcatcctg gcagcgtacg      120

gtgcttgggc tgaggcgaca aaagaggagg aagatgacac agaacgtttg cccagcaaat      180

gcgaagtgtg taagctgctg agcatggagc tccaggaagc gttgagtcga actggccgat      240

cccgagaagt gctggagctg ggtcaggtgc tagacactgg caagaggaag agacacgtgc      300

cttacagcct ctctgagacg cggctagaag aggctttgga gaatttgtgc gagcggatcc      360

tggattacaa tgttcatgct gaacgcaagg gctcactaag atacgccaag ggtcaaagtc      420

agactatggc aacactgaaa ggcctggtcc agaagggagt gaaagtggat ctgggaatcc      480

ctttggagct gtgggacgag cccagtgtgg aggtcacatt cctcaagaag cagtgtgaga      540

cgatgctgga ggagtttgaa gatgttgtag gggactggta cttccaccat caggagcagc      600

ccctccagca ttttctctgt gagcggcatg tgcttccagc ctctgaaact gcttgtctac      660

gggaagcttg gactggaaag gagaagatca gtgatgggca ggaggaggca gatgacgaag      720

aggaggaaga agaagaagag ataaccaaga cttcaggcaa tcccaagcat gacccagaag      780

atctttgacc cttacttttg aaccccaagg atgggtcgtg gagagttttc taaactcttg      840

tgctctcccg tccttccccg cccctaggct tctaatgtct tcttggtatg atctcggcta      900

tgatcctggg gacccagaat ggcaacagga aaggagaagg gtagggggga agaagcagaa      960

gcaagttttg ccttcagggt tgaaccacat gcagccactt aattgaacaa gtatgtggtg     1020

acagttttga aacttttctc tacgttttac tggtcttcac ctgcaccgat tggtcaatag     1080

tggtgtgagc tgtgggaaag tcactttgct ttttaaaggg tctattttaa accctttcaa     1140

gaggccagag aagagcgagc agcgcaattg gtagagtgcc tgcctagtat ggacagtgat     1200

gggagttgaa ccctgatgtg gtggcatacc gctgtaatct cagcactcaa agaagcgttg     1260

gcaggaatat cagaatacca tccagctact tggcagttcg ggaccaacca gagctgaacc     1320

ctgtcttaaa gtaagaagcc aaaaagagac cctcaagaac caatatacac tgcaaacatg     1380

aggccgtata ccatcaatct gtgaataaga acaggatgct ggaagagagt gaagcaatac     1440

tcgggttaga tggggtagac atgtgggcta tatttcctat ttcacaggtg ccatattttc     1500

tatattgcta ttaaaccttt tatatatata tcagctgagt cccatttcaa acatgcacac     1560

attatcgatg agggagcacc cagacagtgg ggccattggc ctgctatcta ttagttgcta     1620

atggtgttct tataattatc caccccaagg atactggttg gggttgggaa aacaactgta     1680

ccactaggac ttggaaaaga ggatcaagag ctcagtcttc ctcagctatg tagcgagctc     1740

aagaccatct tggtctcctt gagcccctgt atcaggaaaa t                         1781


<210>  19
<211>  247
<212>  PRT
<213>  Pan troglodytes

<400>  19

Met Gly Pro Val Arg Leu Gly Ile Leu Leu Phe Leu Phe Leu Ala Val 
1               5                   10                  15      


His Glu Ala Trp Ala Gly Met Leu Lys Glu Glu Asp Asp Asp Thr Glu 
            20                  25                  30          


Arg Leu Pro Ser Lys Cys Glu Val Cys Lys Leu Leu Ser Thr Glu Leu 
        35                  40                  45              


Gln Ala Glu Leu Ser Arg Thr Gly Arg Ser Arg Glu Val Leu Glu Leu 
    50                  55                  60                  


Gly Gln Val Leu Asp Thr Gly Lys Arg Lys Arg His Val Pro Tyr Ser 
65                  70                  75                  80  


Val Ser Glu Thr Arg Leu Glu Glu Ala Leu Glu Asn Leu Cys Glu Arg 
                85                  90                  95      


Ile Leu Asp Tyr Ser Val His Ala Glu Arg Lys Gly Ser Leu Arg Tyr 
            100                 105                 110         


Ala Lys Gly Gln Ser Gln Thr Met Ala Thr Leu Lys Gly Leu Val Gln 
        115                 120                 125             


Lys Gly Val Lys Val Asp Leu Gly Ile Pro Leu Glu Leu Trp Asp Glu 
    130                 135                 140                 


Pro Ser Val Glu Val Thr Tyr Leu Lys Lys Gln Cys Glu Thr Met Leu 
145                 150                 155                 160 


Glu Glu Phe Glu Asp Ile Val Gly Asp Trp Tyr Phe His His Gln Glu 
                165                 170                 175     


Gln Pro Leu Gln Asn Phe Leu Cys Glu Gly His Val Leu Pro Ala Ala 
            180                 185                 190         


Glu Thr Ala Cys Leu Gln Glu Thr Trp Thr Gly Lys Glu Ile Thr Asp 
        195                 200                 205             


Gly Glu Glu Lys Thr Glu Gly Glu Glu Glu Gln Glu Glu Glu Glu Glu 
    210                 215                 220                 


Glu Glu Glu Glu Gly Gly Asp Lys Met Thr Lys Thr Gly Ser His Pro 
225                 230                 235                 240 


Lys Leu Asp Arg Glu Asp Leu 
                245         


<210>  20
<211>  226
<212>  PRT
<213>  Canis lupus familiaris

<400>  20

Met Gly Pro Ile Arg Leu Gly Met Leu Leu Phe Ile Leu Val Val Tyr 
1               5                   10                  15      


Gly Ala Trp Val Gly Thr Ser Lys Glu Asp Asp Asp Thr Glu Arg Leu 
            20                  25                  30          


Pro Ser Lys Cys Glu Val Cys Lys Leu Leu Ser Leu Glu Leu Gln Glu 
        35                  40                  45              


Glu Leu Ser Arg Thr Gly Arg Ser Arg Glu Val Leu Glu Leu Gly Gln 
    50                  55                  60                  


Val Leu Asp Thr Gly Lys Arg Lys Arg His Val Pro Tyr Ser Val Ser 
65                  70                  75                  80  


Glu Thr Arg Leu Glu Glu Ala Leu Glu Asn Leu Cys Glu Arg Ile Leu 
                85                  90                  95      


Asp Tyr Ser Val His Ala Glu Arg Lys Gly Ser Leu Arg Tyr Ala Lys 
            100                 105                 110         


Gly Gln Ser Gln Thr Met Ala Thr Leu Lys Gly Leu Val Gln Lys Gly 
        115                 120                 125             


Val Lys Val Asp Leu Gly Ile Pro Leu Glu Leu Trp Asp Glu Pro Ser 
    130                 135                 140                 


Val Glu Val Thr Phe Leu Lys Lys Gln Cys Glu Thr Met Leu Glu Glu 
145                 150                 155                 160 


Phe Glu Asp Val Ile Gly Asp Trp Tyr Phe His His Gln Glu Gln Pro 
                165                 170                 175     


Leu Gln His Phe Leu Cys Glu Gly His Val Leu Pro Gly Ala Glu Thr 
            180                 185                 190         


Ala Cys Leu Gln Glu Thr Trp Thr Gly Lys Glu Lys Ile Thr Asp Gly 
        195                 200                 205             


Gln Glu Lys Thr Glu Gly Glu Glu Gln Asp Gln Glu Glu Glu Glu Glu 
    210                 215                 220                 


Glu Glu 
225     


<210>  21
<211>  247
<212>  PRT
<213>  Rattus norvegicus

<400>  21

Met Cys Glu Leu Arg Phe Val Met Gly Pro Val Arg Leu Glu Ile Leu 
1               5                   10                  15      


Leu Phe Ile Leu Ala Ala Tyr Gly Ala Trp Thr Gly Met Thr Lys Glu 
            20                  25                  30          


Glu Glu Ala Asp Thr Glu Arg Leu Pro Ser Lys Cys Glu Val Cys Lys 
        35                  40                  45              


Leu Leu Ser Met Glu Leu Gln Glu Glu Leu Ser Arg Thr Gly Arg Ser 
    50                  55                  60                  


Arg Glu Val Leu Glu Leu Gly Gln Val Leu Asp Thr Gly Lys Arg Lys 
65                  70                  75                  80  


Arg His Val Pro Tyr Ser Leu Ser Glu Thr Arg Leu Glu Glu Ala Leu 
                85                  90                  95      


Glu Asn Leu Cys Glu Arg Ile Leu Asp Tyr Asn Val His Ala Glu Arg 
            100                 105                 110         


Lys Gly Ser Leu Arg Tyr Ala Lys Gly Gln Ser Gln Thr Met Ala Thr 
        115                 120                 125             


Leu Lys Gly Leu Val Gln Lys Gly Val Lys Val Asp Leu Gly Ile Pro 
    130                 135                 140                 


Leu Glu Leu Trp Asp Glu Pro Ser Val Glu Val Thr Phe Leu Lys Lys 
145                 150                 155                 160 


Gln Cys Glu Ala Met Leu Glu Glu Phe Glu Asp Val Val Gly Asp Trp 
                165                 170                 175     


Tyr Phe His His Gln Glu Gln Pro Leu Gln His Phe Leu Cys Gly Arg 
            180                 185                 190         


His Val Leu Pro Ala Thr Glu Thr Ala Cys Leu Gln Glu Thr Trp Thr 
        195                 200                 205             


Gly Lys Glu Lys Ile Ser Asp Gly Gln Glu Glu Thr Glu Glu Glu Glu 
    210                 215                 220                 


Glu Glu Lys Glu Glu Asn Lys Glu Ile Thr Lys Thr Ser Gly Thr Pro 
225                 230                 235                 240 


Lys His Asp Pro Glu Asp Leu 
                245         


<210>  22
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Gly Phe Leu Gly Thr Gly Thr Trp Ile Leu Val Leu Val Leu Pro 
1               5                   10                  15      


Ile Gln Ala Phe Pro Lys Pro Gly Gly Ser Gln Asp Lys Ser Leu His 
            20                  25                  30          


Asn Arg Glu Leu Ser Ala Glu Arg Pro Leu Asn Glu Gln Ile Ala Glu 
        35                  40                  45              


Ala Glu Glu Asp Lys Ile Lys Lys Thr Tyr Pro Pro Glu Asn Lys Pro 
    50                  55                  60                  


Gly Gln Ser Asn Tyr Ser Phe Val Asp Asn Leu Asn Leu Leu Lys Ala 
65                  70                  75                  80  


Ile Thr Glu Lys Glu Lys Ile Glu Lys Glu Arg Gln Ser Ile Arg Ser 
                85                  90                  95      


Ser Pro Leu Asp Asn Lys Leu Asn Val Glu Asp Val Asp Ser Thr Lys 
            100                 105                 110         


Asn Arg Lys Leu Ile Asp Asp Tyr Asp Ser Thr Lys Ser Gly Leu Asp 
        115                 120                 125             


His Lys Phe Gln Asp Asp Pro Asp Gly Leu His Gln Leu Asp Gly Thr 
    130                 135                 140                 


Pro Leu Thr Ala Glu Asp Ile Val His Lys Ile Ala Ala Arg Ile Tyr 
145                 150                 155                 160 


Glu Glu Asn Asp Arg Ala Val Phe Asp Lys Ile Val Ser Lys Leu Leu 
                165                 170                 175     


Asn Leu Gly Leu Ile Thr Glu Ser Gln Ala His Thr Leu Glu Asp Glu 
            180                 185                 190         


Val Ala Glu Val Leu Gln Lys Leu Ile Ser Lys Glu Ala Asn Asn Tyr 
        195                 200                 205             


Glu Glu Asp Pro Asn Lys Pro Thr Ser Trp Thr Glu Asn Gln Ala Gly 
    210                 215                 220                 


Lys Ile Pro Glu Lys Val Thr Pro Met Ala Ala Ile Gln Asp Gly Leu 
225                 230                 235                 240 


Ala Lys Gly Glu Asn Asp Glu Thr Val Ser Asn Thr Leu Thr Leu Thr 
                245                 250                 255     


Asn Gly Leu Glu Arg Arg Thr Lys Thr Tyr Ser Glu Asp Asn Phe Glu 
            260                 265                 270         


Glu Leu Gln Tyr Phe Pro Asn Phe Tyr Ala Leu Leu Lys Ser Ile Asp 
        275                 280                 285             


Ser Glu Lys Glu Ala Lys Glu Lys Glu Thr Leu Ile Thr Ile Met Lys 
    290                 295                 300                 


Thr Leu Ile Asp Phe Val Lys Met Met Val Lys Tyr Gly Thr Ile Ser 
305                 310                 315                 320 


Pro Glu Glu Gly Val Ser Tyr Leu Glu Asn Leu Asp Glu Met Ile Ala 
                325                 330                 335     


Leu Gln Thr Lys Asn Lys Leu Glu Lys Asn Ala Thr Asp Asn Ile Ser 
            340                 345                 350         


Lys Leu Phe Pro Ala Pro Ser Glu Lys Ser His Glu Glu Thr Asp Ser 
        355                 360                 365             


Thr Lys Glu Glu Ala Ala Lys Met Glu Lys Glu Tyr Gly Ser Leu Lys 
    370                 375                 380                 


Asp Ser Thr Lys Asp Asp Asn Ser Asn Pro Gly Gly Lys Thr Asp Glu 
385                 390                 395                 400 


Pro Lys Gly Lys Thr Glu Ala Tyr Leu Glu Ala Ile Arg Lys Asn Ile 
                405                 410                 415     


Glu Trp Leu Lys Lys His Asp Lys Lys Gly Asn Lys Glu Asp Tyr Asp 
            420                 425                 430         


Leu Ser Lys Met Arg Asp Phe Ile Asn Lys Gln Ala Asp Ala Tyr Val 
        435                 440                 445             


Glu Lys Gly Ile Leu Asp Lys Glu Glu Ala Glu Ala Ile Lys Arg Ile 
    450                 455                 460                 


Tyr Ser Ser Leu 
465             


<210>  23
<211>  3366
<212>  DNA
<213>  Homo sapiens

<400>  23
gttccattcc cgggggattg gagtagcgtt ggagtcaccg acgccatccc ctcccgcctc       60

tggcgtgcat ggagcatgcg cttccttcct cacttcctct gcaggaggga gcgagagtaa      120

agctacgccc tggcgcgcag tctccgcgtc acaggaactt cagcacccac agggcggaca      180

gcgctcccct ctacctggag acttgactcc cgcgcgcccc aaccctgctt atcccttgac      240

cgtcgagtgt cagagatcct gcagccgccc agtcccggcc cctctcccgc cccacaccca      300

ccctcctggc tcttcctgtt tttactcctc cttttcattc ataacaaaag ctacagctcc      360

aggagcccag cgccgggctg tgacccaagc cgagcgtgga agaatggggt tcctcgggac      420

cggcacttgg attctggtgt tagtgctccc gattcaagct ttccccaaac ctggaggaag      480

ccaagacaaa tctctacata atagagaatt aagtgcagaa agacctttga atgaacagat      540

tgctgaagca gaagaagaca agattaaaaa aacatatcct ccagaaaaca agccaggtca      600

gagcaactat tcttttgttg ataacttgaa cctgctaaag gcaataacag aaaaggaaaa      660

aattgagaaa gaaagacaat ctataagaag ctccccactt gataataagt tgaatgtgga      720

agatgttgat tcaaccaaga atcgaaaact gatcgatgat tatgactcta ctaagagtgg      780

attggatcat aaatttcaag atgatccaga tggtcttcat caactagacg ggactccttt      840

aaccgctgaa gacattgtcc ataaaatcgc tgccaggatt tatgaagaaa atgacagagc      900

cgtgtttgac aagattgttt ctaaactact taatctcggc cttatcacag aaagccaagc      960

acatacactg gaagatgaag tagcagaggt tttacaaaaa ttaatctcaa aggaagccaa     1020

caattatgag gaggatccca ataagcccac aagctggact gagaatcagg ctggaaaaat     1080

accagagaaa gtgactccaa tggcagcaat tcaagatggt cttgctaagg gagaaaacga     1140

tgaaacagta tctaacacat taaccttgac aaatggcttg gaaaggagaa ctaaaaccta     1200

cagtgaagac aactttgagg aactccaata tttcccaaat ttctatgcgc tactgaaaag     1260

tattgattca gaaaaagaag caaaagagaa agaaacactg attactatca tgaaaacact     1320

gattgacttt gtgaagatga tggtgaaata tggaacaata tctccagaag aaggtgtttc     1380

ctaccttgaa aacttggatg aaatgattgc tcttcagacc aaaaacaagc tagaaaaaaa     1440

tgctactgac aatataagca agcttttccc agcaccatca gagaagagtc atgaagaaac     1500

agacagtacc aaggaagaag cagctaagat ggaaaaggaa tatggaagct tgaaggattc     1560

cacaaaagat gataactcca acccaggagg aaagacagat gaacccaaag gaaaaacaga     1620

agcctatttg gaagccatca gaaaaaatat tgaatggttg aagaaacatg acaaaaaggg     1680

aaataaagaa gattatgacc tttcaaagat gagagacttc atcaataaac aagctgatgc     1740

ttatgtggag aaaggcatcc ttgacaagga agaagccgag gccatcaagc gcatttatag     1800

cagcctgtaa aaatggcaaa agatccagga gtctttcaac tgtttcagaa aacataatat     1860

agcttaaaac acttctaatt ctgtgattaa aattttttga cccaagggtt attagaaagt     1920

gctgaattta cagtagttaa ccttttacaa gtggttaaaa catagctttc ttcccgtaaa     1980

aactatctga aagtaaagtt gtatgtaagc tgagattttg tatacagaat ccttatttcc     2040

tcatagactt atattttata atcagaatat gttgctttga aaaagcctct aatggactga     2100

ccttaaaact catccttctt ccactgtctc atccacataa gcactccccg aagaattaag     2160

ggggttctgt tttcaaggca tgccaagtac taaagcacct tgcagagcgt gtctattaca     2220

agatgtcatt tccaccagca gttcccttag gggagctgaa ataaattcac attttctcaa     2280

agtctcatag ctttggagga gccatctgct tttttggctg ctctttttag ctggcttttt     2340

attaggctca gtgacataaa aaggatccag gtaaatgggt ataggatttg ctggatttac     2400

taacaatttc cccctgttct taacacttcc tattagtgac ttttcagaca ttgagtttac     2460

ttataaagag agatatttat gtactctcta agaagacaaa tgaggtcata aacactgcat     2520

aaagcaaggc aaaaatgtat gccacatctc agttatctaa actagattag atccaagcca     2580

agttttctca acagagagca aagggccagg cagtaaggta gaaatagaga taaaaatcat     2640

tccttccttg tgatccaaag ctggtcgagc agctttcctg gaggaaaagg ttaatgaact     2700

tcaggtccct gcaactcagc ccccaccaca aacacagccc tggaaacata cagtggcgca     2760

aggtcctctt gaaatgttaa tggttaatgt tcccaaacca gagaatgctt tgaaaatgta     2820

tcattcagtg taaattaatt acatacatat ttttctatat atttgtttca aactgtaaaa     2880

ataacataat atgtaatttg tgtattagtg agaggtgaag ccagctggac ttcctgggtc     2940

gagtggggcc ttggagaact tttctgtctt acaagaggat tgtaaaatgc acccatcagt     3000

gctctgtaaa acacaccaat cagcgctctg tagctagcaa taggtttgta aaatgcaccc     3060

atcagcactc tgtaaaacgc accaatcagc actctgtaaa atgcaccaat cagcaggatt     3120

ctaaaagtag acaatcacag ggaggattga aaaaaagggc actctgatag ggcaaaaacg     3180

gaacatggga ggggacaaat aagggaataa aatctggcca ccccagccag cagcagcaac     3240

ctgttcaggt cgcctgccgc tgtggaagct ttgtcctttt gctcttcata ataaaccttg     3300

ctactgttca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3360

aaaaaa                                                                3366


<210>  24
<211>  471
<212>  PRT
<213>  Mus musculus

<400>  24

Met Gly Phe Leu Trp Thr Gly Ser Trp Ile Leu Val Leu Val Leu Asn 
1               5                   10                  15      


Ser Gly Pro Ile Gln Ala Phe Pro Lys Pro Glu Gly Ser Gln Asp Lys 
            20                  25                  30          


Ser Leu His Asn Arg Glu Leu Ser Ala Glu Arg Pro Leu Asn Glu Gln 
        35                  40                  45              


Ile Ala Glu Ala Glu Ala Asp Lys Ile Lys Lys Ala Phe Pro Ser Glu 
    50                  55                  60                  


Ser Lys Pro Ser Glu Ser Asn Tyr Ser Ser Val Asp Asn Leu Asn Leu 
65                  70                  75                  80  


Leu Arg Ala Ile Thr Glu Lys Glu Thr Val Glu Lys Glu Arg Gln Ser 
                85                  90                  95      


Ile Arg Ser Pro Pro Phe Asp Asn Gln Leu Asn Val Glu Asp Ala Asp 
            100                 105                 110         


Ser Thr Lys Asn Arg Lys Leu Ile Asp Glu Tyr Asp Ser Thr Lys Ser 
        115                 120                 125             


Gly Leu Asp His Lys Phe Gln Asp Asp Pro Asp Gly Leu His Gln Leu 
    130                 135                 140                 


Asp Gly Thr Pro Leu Thr Ala Glu Asp Ile Val His Lys Ile Ala Thr 
145                 150                 155                 160 


Arg Ile Tyr Glu Glu Asn Asp Arg Gly Val Phe Asp Lys Ile Val Ser 
                165                 170                 175     


Lys Leu Leu Asn Leu Gly Leu Ile Thr Glu Ser Gln Ala His Thr Leu 
            180                 185                 190         


Glu Asp Glu Val Ala Glu Ala Leu Gln Lys Leu Ile Ser Lys Glu Ala 
        195                 200                 205             


Asn Asn Tyr Glu Glu Thr Leu Asp Lys Pro Thr Ser Arg Thr Glu Asn 
    210                 215                 220                 


Gln Asp Gly Lys Ile Pro Glu Lys Val Thr Pro Val Ala Ala Val Gln 
225                 230                 235                 240 


Asp Gly Phe Thr Asn Arg Glu Asn Asp Glu Thr Val Ser Asn Thr Leu 
                245                 250                 255     


Thr Leu Ser Asn Gly Leu Glu Arg Arg Thr Asn Pro His Arg Glu Asp 
            260                 265                 270         


Asp Phe Glu Glu Leu Gln Tyr Phe Pro Asn Phe Tyr Ala Leu Leu Thr 
        275                 280                 285             


Ser Ile Asp Ser Glu Lys Glu Ala Lys Glu Lys Glu Thr Leu Ile Thr 
    290                 295                 300                 


Ile Met Lys Thr Leu Ile Asp Phe Val Lys Met Met Val Lys Tyr Gly 
305                 310                 315                 320 


Thr Ile Ser Pro Glu Glu Gly Val Ser Tyr Leu Glu Asn Leu Asp Glu 
                325                 330                 335     


Thr Ile Ala Leu Gln Thr Lys Asn Lys Leu Glu Lys Asn Thr Thr Asp 
            340                 345                 350         


Ser Lys Ser Lys Leu Phe Pro Ala Pro Pro Glu Lys Ser Gln Glu Glu 
        355                 360                 365             


Thr Asp Ser Thr Lys Glu Glu Ala Ala Lys Met Glu Lys Glu Tyr Gly 
    370                 375                 380                 


Ser Leu Lys Asp Ser Thr Lys Asp Asp Asn Ser Asn Leu Gly Gly Lys 
385                 390                 395                 400 


Thr Asp Glu Ala Thr Gly Lys Thr Glu Ala Tyr Leu Glu Ala Ile Arg 
                405                 410                 415     


Lys Asn Ile Glu Trp Leu Lys Lys His Asn Lys Lys Gly Asn Lys Glu 
            420                 425                 430         


Asp Tyr Asp Leu Ser Lys Met Arg Asp Phe Ile Asn Gln Gln Ala Asp 
        435                 440                 445             


Ala Tyr Val Glu Lys Gly Ile Leu Asp Lys Glu Glu Ala Asn Ala Ile 
    450                 455                 460                 


Lys Arg Ile Tyr Ser Ser Leu 
465                 470     


<210>  25
<211>  2207
<212>  DNA
<213>  Mus musculus

<400>  25
ggagcatgcg cctcctcctc atttcctctc ctggagctag tggagtaaag ctacgcccag       60

gcccgcgtcc gctggcggcg caggaacttc agcacccgcg gggcggacag cgcctaccgc      120

acctgctcac ctgctctggg cgccagaaga gcctgcatcc tccttccagc ccggagcaac      180

tgcgccggag gcgcccagac cctctccctt cccgcaccca ggctcctgtc ccttccagct      240

tcttaactcc ccttctcatt cataacaaaa gctacagctc aggggcccag cgccaagctc      300

tttccagcaa agcacagaag agcaagaaag aatggggttc ctttggaccg gctcttggat      360

actggtgttg gtgctcaaca gcggcccaat tcaagctttc cccaaacccg aaggcagcca      420

agacaaatcc ctgcataata gagaattaag tgcagaaaga cctttgaatg aacagatcgc      480

tgaggcagag gcagacaaga ttaaaaaggc attcccttca gaaagcaagc cgagtgaaag      540

caattattct tctgtcgata acttgaatct gctgagggca ataacagaaa aggaaaccgt      600

tgagaaagag agacaatcca taagaagccc cccgtttgat aaccaactga acgtggaaga      660

cgctgattca accaaaaatc ggaaactgat cgatgagtac gattccacca agagtggact      720

ggaccacaag tttcaagatg acccagacgg ccttcatcaa ctggatggaa ctcctttaac      780

tgctgaagac atcgtccata agattgccac caggatttat gaggagaacg acagaggagt      840

gtttgacaaa attgtttcta aactgctgaa tcttggcctg atcactgaaa gccaggcaca      900

tactctggaa gatgaagtag cagaagcttt acaaaaactg atttcaaaag aggccaacaa      960

ttatgaggag accctggata aacccacaag caggaccgag aatcaggatg ggaaaatacc     1020

agagaaagtg actccggtgg cagcagtcca agatggcttc actaaccgtg aaaacgatga     1080

gacggtgtct aacaccttga ccttgtccaa tggcttggaa aggagaacta acccccacag     1140

ggaagacgac tttgaggaac tccagtattt ccccaacttc tatgcactac tgacaagcat     1200

cgactcagaa aaagaagcaa aagagaaaga aaccctgatc accatcatga agacattgat     1260

tgacttcgtg aaaatgatgg tgaaatacgg tacgatatct ccagaggaag gcgtgtccta     1320

ccttgaaaac ttggatgaaa caattgctct gcagaccaag aacaagctag aaaaaaatac     1380

tactgatagc aaaagtaagc tattcccagc tccaccagag aagagtcagg aagaaacaga     1440

cagtaccaag gaagaagccg ccaagatgga aaaggaatac ggaagcctaa aagactctac     1500

aaaagatgat aactccaacc taggaggaaa gacagatgaa gccacaggga agacagaagc     1560

ctacttggaa gccattagaa aaaacatcga atggctgaag aaacataaca agaagggcaa     1620

caaagaagat tacgaccttt caaagatgag ggactttatc aaccaacaag ctgacgctta     1680

tgtggagaag ggcatcctcg acaaggaaga agccaacgcc atcaaacgca tctacagcag     1740

cctgtgaaaa tggcgggcag cttgagcctt cctgttgttc cagcaaaaac aatatagctt     1800

acaaactaat tcggcggtta aagggttacc agcccagaag tattaggatg tgctgaattt     1860

atagtagtta atcccttaga aatgagtaaa atagagctct cttgccataa ataccttatg     1920

aaaagcaaag ctgtagagaa gccgaggttt ttctatatag aatccttatt tcctcttgaa     1980

tttacatttt gtaatcagag atgtgctgct ctggaaaaga ctctaatggg ttgaacataa     2040

gtctgaacct actccccact gtcctcagcc ccctgaagct ctgagaggcc ctgtctcggc     2100

atgctagaca cctgagcacc tcactggatg tttgtcatag gatgtcgttt ccactagtcg     2160

atctctgttg ggcacggaaa taaacccacg tctcttcata tccttga                   2207


<210>  26
<211>  468
<212>  PRT
<213>  Pan troglodytes

<400>  26

Met Gly Phe Leu Gly Thr Ser Thr Trp Ile Leu Val Leu Val Leu Pro 
1               5                   10                  15      


Ile Gln Ala Phe Pro Lys Pro Gly Gly Ser Gln Asp Lys Ser Leu His 
            20                  25                  30          


Asn Arg Glu Leu Ser Ala Glu Arg Pro Leu Asn Glu Gln Ile Ala Glu 
        35                  40                  45              


Ala Glu Glu Asp Lys Ile Lys Lys Thr Tyr Pro Pro Glu Asn Lys Pro 
    50                  55                  60                  


Gly Gln Ser Asn Tyr Ser Phe Val Asp Asn Leu Asn Leu Leu Lys Ala 
65                  70                  75                  80  


Ile Thr Glu Lys Glu Lys Ile Glu Lys Glu Arg Gln Ser Ile Arg Ser 
                85                  90                  95      


Ser Pro Leu Asp Asn Lys Leu Asn Val Glu Asp Val Asp Ser Thr Lys 
            100                 105                 110         


Asn Arg Lys Leu Ile Asp Asp Tyr Asp Ser Thr Lys Ser Gly Leu Asp 
        115                 120                 125             


His Lys Phe Gln Asp Asp Pro Asp Gly Leu His Gln Leu Asp Gly Thr 
    130                 135                 140                 


Pro Leu Thr Ala Glu Asp Ile Val His Lys Ile Ala Ala Arg Ile Tyr 
145                 150                 155                 160 


Glu Glu Asn Asp Arg Ala Val Phe Asp Lys Ile Val Ser Lys Leu Leu 
                165                 170                 175     


Asn Leu Gly Leu Ile Thr Glu Ser Gln Ala His Thr Leu Glu Asp Glu 
            180                 185                 190         


Val Ala Glu Val Leu Gln Lys Leu Ile Ser Lys Glu Ala Asn Asn Tyr 
        195                 200                 205             


Glu Glu Asp Pro Asn Lys Pro Thr Ser Trp Thr Glu Asn Gln Ala Gly 
    210                 215                 220                 


Lys Ile Pro Glu Lys Val Thr Pro Met Ala Ala Ile Gln Asp Gly Leu 
225                 230                 235                 240 


Ala Lys Gly Glu Asn Asp Glu Thr Val Ser Asn Thr Leu Thr Leu Thr 
                245                 250                 255     


Asn Gly Leu Glu Arg Arg Thr Lys Thr Tyr Ser Glu Asp Asn Phe Glu 
            260                 265                 270         


Glu Leu Gln Tyr Phe Pro Asn Phe Tyr Ala Leu Leu Lys Ser Ile Asp 
        275                 280                 285             


Ser Glu Lys Glu Ala Lys Glu Lys Glu Thr Leu Ile Thr Ile Met Lys 
    290                 295                 300                 


Thr Leu Ile Asp Phe Val Lys Met Met Val Lys Tyr Gly Thr Ile Ser 
305                 310                 315                 320 


Pro Glu Glu Gly Val Ser Tyr Leu Glu Asn Leu Asp Glu Met Ile Ala 
                325                 330                 335     


Leu Gln Thr Lys Asn Lys Leu Glu Lys Asn Ala Thr Asp Asn Ile Ser 
            340                 345                 350         


Lys Leu Phe Pro Ala Pro Ser Glu Lys Ser His Glu Glu Thr Asp Ser 
        355                 360                 365             


Thr Lys Glu Glu Ala Ala Lys Met Glu Lys Glu Tyr Gly Ser Leu Lys 
    370                 375                 380                 


Asp Ser Thr Lys Asp Asp Asn Ser Asn Pro Gly Gly Lys Thr Asp Glu 
385                 390                 395                 400 


Pro Lys Gly Lys Thr Glu Ala Tyr Leu Glu Ala Ile Arg Lys Asn Ile 
                405                 410                 415     


Glu Trp Leu Lys Lys His Asp Lys Lys Gly Asn Lys Glu Asp Tyr Asp 
            420                 425                 430         


Leu Ser Lys Met Arg Asp Phe Ile Asn Lys Gln Ala Asp Ala Tyr Val 
        435                 440                 445             


Glu Lys Gly Ile Leu Asp Lys Glu Glu Ala Glu Ala Ile Lys Arg Ile 
    450                 455                 460                 


Tyr Ser Ser Leu 
465             


<210>  27
<211>  469
<212>  PRT
<213>  Canis lupus familiaris

<400>  27

Met Gly Phe Leu Trp Thr Gly Thr Trp Ile Leu Val Leu Val Leu Gln 
1               5                   10                  15      


Ser Ser Pro Thr Gln Ala Phe Pro Lys Pro Gly Gly Ser Pro Asp Lys 
            20                  25                  30          


Pro Leu His Asn Arg Glu Leu Ser Ala Glu Arg Pro Leu Asn Glu Gln 
        35                  40                  45              


Ile Ala Glu Ala Glu Ala Asp Lys Ile Lys Lys Thr Tyr Pro Pro Glu 
    50                  55                  60                  


Asn Lys Pro Gly Glu Ser Asn Tyr Ser Phe Val Asp Asn Leu Asn Leu 
65                  70                  75                  80  


Leu Lys Ala Ile Thr Glu Lys Glu Lys Ile Glu Lys Glu Arg Gln Ser 
                85                  90                  95      


Ile Arg Ser Ser Pro Tyr Asp Asn Lys Leu Asn Val Glu Asp Val Asp 
            100                 105                 110         


Ser Thr Lys Asn Arg Arg Leu Ile Asp Asp Tyr Asp Ser Thr Lys Ser 
        115                 120                 125             


Gly Leu Asn His Lys Phe Gln Asp Asp Pro Asp Gly Leu His Gln Leu 
    130                 135                 140                 


Asp Gly Thr Pro Leu Thr Ala Glu Asp Ile Val Gln Lys Ile Ala Thr 
145                 150                 155                 160 


Arg Ile Tyr Glu Glu Asn Asp Arg Gly Val Phe Asp Lys Ile Val Ser 
                165                 170                 175     


Lys Leu Leu Asn Leu Gly Leu Ile Thr Glu Ser Gln Ala His Ile Leu 
            180                 185                 190         


Glu Asp Glu Val Ala Glu Val Leu Gln Lys Leu Ile Ser Lys Glu Ala 
        195                 200                 205             


Asn Thr Tyr Glu Glu Glu Pro Asn Lys Pro Thr Ser Val Thr Glu Ser 
    210                 215                 220                 


Gln Ala Gly Lys Ile Pro Glu Lys Val Thr Pro Met Ala Ala Ile Gln 
225                 230                 235                 240 


Asp Gly Phe Thr Asn Gly Gln Asn Asp Glu Thr Val Ser Asn Thr Leu 
                245                 250                 255     


Thr Leu Thr Asn Gly Leu Glu Arg Arg Thr Lys Ile Tyr Asn Glu Asp 
            260                 265                 270         


Asn Phe Glu Glu Leu Gln Tyr Phe Pro Asn Phe Tyr Ala Leu Leu Lys 
        275                 280                 285             


Ser Ile Asp Ser Glu Lys Glu Ala Lys Glu Lys Glu Thr Leu Ile Thr 
    290                 295                 300                 


Ile Met Lys Thr Leu Ile Asp Phe Val Lys Met Met Val Lys Tyr Gly 
305                 310                 315                 320 


Thr Ile Ser Pro Glu Glu Gly Val Ser Tyr Leu Glu Asn Leu Asp Glu 
                325                 330                 335     


Thr Ile Ala Leu Gln Thr Lys Asn Lys Leu Glu Lys Asn Val Thr Asp 
            340                 345                 350         


Asn Lys Ser Lys Leu Phe Pro Ala Pro Ser Glu Lys Ser His Glu Glu 
        355                 360                 365             


Thr Asp Ser Thr Lys Glu Glu Ala Ala Lys Met Glu Lys Glu Tyr Gly 
    370                 375                 380                 


Thr Leu Lys Asp Ser Thr Lys Asp Asp Asn Pro Arg Gly Lys Thr Asp 
385                 390                 395                 400 


Glu Pro Lys Gly Lys Thr Glu Ala Tyr Leu Glu Ala Ile Arg Lys Asn 
                405                 410                 415     


Ile Glu Trp Leu Lys Lys His Asn Lys Lys Gly Asn Lys Glu Asp Tyr 
            420                 425                 430         


Asp Leu Ser Lys Met Arg Asp Phe Ile Asn Gln Gln Ala Asp Ala Tyr 
        435                 440                 445             


Val Glu Lys Gly Ile Leu Asp Lys Glu Glu Ala Asn Ala Ile Lys Arg 
    450                 455                 460                 


Ile Tyr Ser Ser Leu 
465                 


<210>  28
<211>  471
<212>  PRT
<213>  Rattus norvegicus

<400>  28

Met Gly Phe Leu Trp Thr Gly Ser Trp Ile Leu Val Leu Val Leu Asn 
1               5                   10                  15      


Ser Gly Pro Ile Gln Ala Phe Pro Lys Pro Glu Gly Ser Gln Asp Lys 
            20                  25                  30          


Ser Leu His Asn Arg Glu Leu Ser Ala Glu Arg Pro Leu Asn Glu Gln 
        35                  40                  45              


Ile Ala Glu Ala Glu Ala Asp Lys Ile Lys Lys Thr Tyr Pro Ser Glu 
    50                  55                  60                  


Ser Lys Pro Ser Glu Ser Asn Phe Ser Ser Val Asp Asn Leu Asn Leu 
65                  70                  75                  80  


Leu Lys Ala Ile Thr Glu Lys Glu Thr Val Glu Lys Ala Lys Gln Ser 
                85                  90                  95      


Ile Arg Ser Ser Pro Phe Asp Asn Arg Leu Asn Val Asp Asp Ala Asp 
            100                 105                 110         


Ser Thr Lys Asn Arg Lys Leu Thr Asp Glu Tyr Asp Ser Thr Lys Ser 
        115                 120                 125             


Gly Leu Asp Arg Lys Val Gln Asp Asp Pro Asp Gly Leu His Gln Leu 
    130                 135                 140                 


Asp Gly Thr Pro Leu Thr Ala Glu Asp Ile Val His Lys Ile Ala Thr 
145                 150                 155                 160 


Arg Ile Tyr Glu Glu Asn Asp Arg Gly Val Phe Asp Lys Ile Val Ser 
                165                 170                 175     


Lys Leu Leu Asn Leu Gly Leu Ile Thr Glu Ser Gln Ala His Thr Leu 
            180                 185                 190         


Glu Asp Glu Val Ala Glu Ala Leu Gln Lys Leu Ile Ser Lys Glu Ala 
        195                 200                 205             


Asn Asn Tyr Glu Glu Ala Pro Glu Lys Pro Thr Ser Arg Thr Glu Asn 
    210                 215                 220                 


Gln Asp Gly Lys Ile Pro Glu Lys Val Thr Pro Val Ala Ala Thr Gln 
225                 230                 235                 240 


Asp Gly Phe Thr Asn Arg Glu Asn Asp Asp Thr Val Ser Asn Thr Leu 
                245                 250                 255     


Thr Leu Ser Asn Gly Leu Glu Arg Arg Thr Asn Pro His Arg Asp Asp 
            260                 265                 270         


Asp Phe Glu Glu Leu Gln Tyr Phe Pro Asn Phe Tyr Ala Leu Leu Thr 
        275                 280                 285             


Ser Ile Asp Ser Glu Lys Glu Ala Lys Glu Lys Glu Thr Leu Ile Thr 
    290                 295                 300                 


Ile Met Lys Thr Leu Ile Asp Phe Val Lys Met Met Val Lys Tyr Gly 
305                 310                 315                 320 


Thr Ile Ser Pro Glu Glu Gly Val Ser Tyr Leu Glu Asn Leu Asp Glu 
                325                 330                 335     


Thr Ile Ala Leu Gln Thr Lys Asn Lys Leu Glu Lys Asn Thr Thr Asp 
            340                 345                 350         


Ser Lys Ser Lys Leu Phe Pro Ala Pro Pro Glu Lys Ser His Glu Glu 
        355                 360                 365             


Thr Asp Ser Thr Lys Glu Glu Ala Ala Lys Met Glu Lys Glu Tyr Gly 
    370                 375                 380                 


Ser Leu Lys Asp Ser Thr Lys Asp Asp Asn Ser Asn Leu Gly Gly Lys 
385                 390                 395                 400 


Thr Asp Glu Ala Lys Gly Lys Thr Glu Ala Tyr Leu Glu Ala Ile Arg 
                405                 410                 415     


Lys Asn Ile Glu Trp Leu Lys Lys His Asn Lys Lys Gly Asn Lys Glu 
            420                 425                 430         


Asp Tyr Asp Leu Ser Lys Met Arg Asp Phe Ile Asn Gln Gln Ala Asp 
        435                 440                 445             


Ala Tyr Val Glu Lys Gly Ile Leu Asp Lys Glu Glu Ala Asn Ala Ile 
    450                 455                 460                 


Lys Arg Ile Tyr Ser Ser Leu 
465                 470     


<210>  29
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Leu Leu Pro Gln Leu Cys Trp Leu Pro Leu Leu Ala Gly Leu Leu 
1               5                   10                  15      


Pro Pro Val Pro Ala Gln Lys Phe Ser Ala Leu Thr Phe Leu Arg Val 
            20                  25                  30          


Asp Gln Asp Lys Asp Lys Asp Cys Ser Leu Asp Cys Ala Gly Ser Pro 
        35                  40                  45              


Gln Lys Pro Leu Cys Ala Ser Asp Gly Arg Thr Phe Leu Ser Arg Cys 
    50                  55                  60                  


Glu Phe Gln Arg Ala Lys Cys Lys Asp Pro Gln Leu Glu Ile Ala Tyr 
65                  70                  75                  80  


Arg Gly Asn Cys Lys Asp Val Ser Arg Cys Val Ala Glu Arg Lys Tyr 
                85                  90                  95      


Thr Gln Glu Gln Ala Arg Lys Glu Phe Gln Gln Val Phe Ile Pro Glu 
            100                 105                 110         


Cys Asn Asp Asp Gly Thr Tyr Ser Gln Val Gln Cys His Ser Tyr Thr 
        115                 120                 125             


Gly Tyr Cys Trp Cys Val Thr Pro Asn Gly Arg Pro Ile Ser Gly Thr 
    130                 135                 140                 


Ala Val Ala His Lys Thr Pro Arg Cys Pro Gly Ser Val Asn Glu Lys 
145                 150                 155                 160 


Leu Pro Gln Arg Glu Gly Thr Gly Lys Thr Asp Asp Ala Ala Ala Pro 
                165                 170                 175     


Ala Leu Glu Thr Gln Pro Gln Gly Asp Glu Glu Asp Ile Ala Ser Arg 
            180                 185                 190         


Tyr Pro Thr Leu Trp Thr Glu Gln Val Lys Ser Arg Gln Asn Lys Thr 
        195                 200                 205             


Asn Lys Asn Ser Val Ser Ser Cys Asp Gln Glu His Gln Ser Ala Leu 
    210                 215                 220                 


Glu Glu Ala Lys Gln Pro Lys Asn Asp Asn Val Val Ile Pro Glu Cys 
225                 230                 235                 240 


Ala His Gly Gly Leu Tyr Lys Pro Val Gln Cys His Pro Ser Thr Gly 
                245                 250                 255     


Tyr Cys Trp Cys Val Leu Val Asp Thr Gly Arg Pro Ile Pro Gly Thr 
            260                 265                 270         


Ser Thr Arg Tyr Glu Gln Pro Lys Cys Asp Asn Thr Ala Arg Ala His 
        275                 280                 285             


Pro Ala Lys Ala Arg Asp Leu Tyr Lys Gly Arg Gln Leu Gln Gly Cys 
    290                 295                 300                 


Pro Gly Ala Lys Lys His Glu Phe Leu Thr Ser Val Leu Asp Ala Leu 
305                 310                 315                 320 


Ser Thr Asp Met Val His Ala Ala Ser Asp Pro Ser Ser Ser Ser Gly 
                325                 330                 335     


Arg Leu Ser Glu Pro Asp Pro Ser His Thr Leu Glu Glu Arg Val Val 
            340                 345                 350         


His Trp Tyr Phe Lys Leu Leu Asp Lys Asn Ser Ser Gly Asp Ile Gly 
        355                 360                 365             


Lys Lys Glu Ile Lys Pro Phe Lys Arg Phe Leu Arg Lys Lys Ser Lys 
    370                 375                 380                 


Pro Lys Lys Cys Val Lys Lys Phe Val Glu Tyr Cys Asp Val Asn Asn 
385                 390                 395                 400 


Asp Lys Ser Ile Ser Val Gln Glu Leu Met Gly Cys Leu Gly Val Ala 
                405                 410                 415     


Lys Glu Asp Gly Lys Ala Asp Thr Lys Lys Arg His Thr Pro Arg Gly 
            420                 425                 430         


His Ala Glu Ser Thr Ser Asn Arg Gln Pro Arg Lys Gln Gly 
        435                 440                 445     


<210>  30
<211>  3117
<212>  DNA
<213>  Homo sapiens

<400>  30
gggtatttga caggagcgag ggcggacgca aagaacgcgg aggacctctg ggtgcctgca       60

ggggagctgc tccagccggg ccgccgggag cggtggggag agcatcgcgg agccgcccct      120

ccacgcgccc gcccagccgc gctcgcccac tgggctctcc cggctgcagt gccagggcgc      180

aggacgcggc cgatctcccg ctcccgccac ctccgccacc atgctgctcc cccagctctg      240

ctggctgccg ctgctcgctg ggctgctccc gccggtgccc gctcagaagt tctcggcgct      300

cacgtttttg agagtggatc aagataaaga caaggattgt agcttggact gtgcgggttc      360

gccccagaaa cctctctgcg catctgacgg aaggaccttc ctttcccgtt gtgaatttca      420

acgtgccaag tgcaaagatc cccagctaga gattgcatat cgaggaaact gcaaagacgt      480

gtccaggtgt gtggccgaaa ggaagtatac ccaggagcaa gcccggaagg agtttcagca      540

agtgttcatt cctgagtgca atgacgacgg cacctacagt caggtccagt gtcacagcta      600

cacgggatac tgctggtgcg tcacgcccaa cgggaggccc atcagcggca ctgccgtggc      660

ccacaagacg ccccggtgcc cgggttccgt aaatgaaaag ttaccccaac gcgaaggcac      720

aggaaaaaca gatgatgccg cagctccagc gttggagact cagcctcaag gagatgaaga      780

agatattgca tcacgttacc ctaccctttg gactgaacag gttaaaagtc ggcagaacaa      840

aaccaataag aattcagtgt catcctgtga ccaagagcac cagtctgccc tggaggaagc      900

caagcagccc aagaacgaca atgtggtgat ccctgagtgt gcgcacggcg gcctctacaa      960

gccagtgcag tgccacccct ccacggggta ctgctggtgc gtcctggtgg acacggggcg     1020

ccccattccc ggcacatcca caaggtacga gcagccgaaa tgtgacaaca cggccagggc     1080

ccacccagcc aaagcccggg acctgtacaa gggccgccag ctacaaggtt gtccgggtgc     1140

caaaaagcat gagtttctga ccagcgttct ggacgcgctg tccacggaca tggtccacgc     1200

cgcctccgac ccctcctcct cgtcaggcag gctctcagaa cccgacccca gccataccct     1260

agaggagcgg gtggtgcact ggtacttcaa actactggat aaaaactcca gtggagacat     1320

cggcaaaaag gaaatcaaac ccttcaagag gttccttcgc aaaaaatcaa agcccaaaaa     1380

atgtgtgaag aagtttgttg aatactgtga cgtgaataat gacaaatcca tctccgtaca     1440

agaactgatg ggctgcctgg gcgtggcgaa agaggacggc aaagcggaca ccaagaaacg     1500

ccacaccccc agaggtcatg ctgaaagtac gtctaataga cagccaagga aacaaggata     1560

aatggctcat accccgaagg cagttcctag acacatggga aatttccctc accaaagagc     1620

aattaagaaa acaaaaacag aaacacatag tatttgcact ttgtacttta aatgtaaatt     1680

cactttgtag aaatgagcta tttaaacaga ctgttttaat ctgtgaaaat ggagagctgg     1740

cttcagaaaa ttaatcacat acaatgtatg tgtcctcttt tgaccttgga aatctgtatg     1800

tggtggagaa gtatttgaat gcatttaggc ttaatttctt cgccttccac atgttaacag     1860

tagagctcta tgcactccgg ctgcaatcgt atggctttct ctaacccctg cagtcacttc     1920

cagatgcctg tgcttacagc attgtggaat catgttggaa gctccacatg tccatggaag     1980

tttgtgatgt acggccgacc ctacaggcag ttaacatgca tgggctggtt tgtttcttgg     2040

gattttctgt tagtttgtct tgttttgctt tccagagatc ttgctcatac aatgaatcac     2100

gcaaccacta aagctatcca gttaagtgca ggtagttccc ctggaggaaa taatattttc     2160

aaactgtcgt tggtgtgata ctttggctca aaggatcttt gcttttccat tttaagcttc     2220

tgttttgagt tttgccctgg ggcttgaatg agtcccagag agtcgttcgg atggtgggag     2280

gctgcctagg aggcagtaaa tccagtcaca gtgcctggga ggggcccatc cttccaaaat     2340

gtaaatccag tcgcggtgtg accgagctgg ctaacaggct tgtctgcctg gttttcctcc     2400

tacacgtgga cattattctc ctgatcctcc tacctggtcc accccagggc taccggaagg     2460

taaaatcttc acctgaacca attatgagca gtctccttac tgaaggtaca gccggatacg     2520

tggtgccccc ggggctggtg ttggcagccg gggggaggtg cctgagggtc cccacggttc     2580

ctttctgctt ttctgaatgc atcaagggta cgagaacttg ccaatgggaa attcatccga     2640

gtggcactgg cagagaagga taggagtgga atgcccacac agtgaccaac agaactggtc     2700

tgcgtgcata accagctgcc accctcaggc ctgggcccca gagctcaggg cacccagtgt     2760

cttaaggaac catttggagg acagtctgag agcaggaact tcaagctgtg attctatctc     2820

ggctcagact tttggttgga aaaagatctt catggcccca aatcccctga gacatgcctt     2880

gtagaatgat tttgtgatgt tgtgatgctt gtggagcatc gcgtaaggct tcttgcttat     2940

ttaaactgtg caaggtaaaa atcaagcctt tggagccaca gaaccagctc aagtacatgc     3000

caatgttgtt taagaaacag ttatgatcct aaactttttg gataatcttt tatatttctg     3060

acctttgaat ttaatcattg ttcttagatt aaaataaaat atgctattga aactata        3117


<210>  31
<211>  447
<212>  PRT
<213>  Mus musculus

<400>  31

Met Leu Pro Pro Gln Leu Cys Trp Leu Pro Leu Leu Ala Ala Leu Leu 
1               5                   10                  15      


Pro Pro Val Pro Ala Gln Lys Phe Ser Ala Leu Thr Phe Leu Arg Val 
            20                  25                  30          


Asp Gln Asp Lys Asp Arg Asp Cys Ser Leu Asp Cys Pro Ser Ser Pro 
        35                  40                  45              


Gln Lys Pro Leu Cys Ala Ser Asp Gly Arg Thr Phe Leu Ser Arg Cys 
    50                  55                  60                  


Glu Phe Gln Arg Ala Lys Cys Lys Asp Pro Gln Leu Glu Ile Ala His 
65                  70                  75                  80  


Arg Gly Asn Cys Lys Asp Val Ser Arg Cys Val Ala Glu Arg Lys Tyr 
                85                  90                  95      


Thr Gln Glu Gln Ala Arg Lys Glu Phe Gln Gln Val Phe Ile Pro Glu 
            100                 105                 110         


Cys Asn Asp Asp Gly Thr Tyr Ser Gln Val Gln Cys His Ser Tyr Thr 
        115                 120                 125             


Gly Tyr Cys Trp Cys Val Thr Pro Asn Gly Arg Pro Ile Ser Gly Thr 
    130                 135                 140                 


Ala Val Ala His Lys Thr Pro Arg Cys Pro Gly Ser Ile Asn Glu Lys 
145                 150                 155                 160 


Val Pro Gln Arg Glu Gly Ala Gly Lys Ala Asp Asp Ala Ala Ala Pro 
                165                 170                 175     


Ala Leu Glu Thr Gln Pro Gln Gly Asp Glu Glu Asp Ile Ala Ser Arg 
            180                 185                 190         


Tyr Pro Thr Leu Trp Thr Glu Gln Val Lys Ser Arg Gln Asn Lys Thr 
        195                 200                 205             


Asn Lys Asn Ser Ala Ser Ser Cys Asp Gln Glu His Gln Ser Ala Leu 
    210                 215                 220                 


Glu Glu Ala Lys Gln Pro Lys Asn Asp Asn Val Val Ile Pro Glu Cys 
225                 230                 235                 240 


Ala His Gly Gly Leu Tyr Lys Pro Val Gln Cys His Pro Ser Thr Gly 
                245                 250                 255     


Tyr Cys Trp Cys Val Leu Val Asp Thr Gly Arg Pro Ile Pro Gly Thr 
            260                 265                 270         


Ser Thr Arg Tyr Glu Gln Pro Lys Cys Asp Asn Thr Ala Arg Ala His 
        275                 280                 285             


Pro Ala Lys Ala Arg Asp Leu Tyr Lys Asn Arg Pro Leu Gln Gly Cys 
    290                 295                 300                 


Pro Gly Ala Lys Lys His Glu Phe Leu Thr Ser Val Leu Asp Ala Leu 
305                 310                 315                 320 


Ser Thr Asp Met Val His Ala Val Ser Asp Pro Ser Ser Ser Ser Gly 
                325                 330                 335     


Arg Leu Ser Glu Pro Asp Pro Ser His Thr Leu Glu Glu Arg Val Val 
            340                 345                 350         


His Trp Tyr Phe Lys Leu Leu Asp Lys Asn Ser Ser Gly Asp Ile Gly 
        355                 360                 365             


Lys Lys Glu Ile Lys Pro Phe Lys Arg Phe Leu Arg Lys Lys Ser Lys 
    370                 375                 380                 


Pro Lys Lys Cys Val Lys Lys Phe Val Glu Tyr Cys Asp Met Asn Asn 
385                 390                 395                 400 


Asp Lys Ser Ile Thr Val Gln Glu Leu Met Gly Cys Leu Gly Val Thr 
                405                 410                 415     


Arg Glu Glu Gly Lys Ala Asn Thr Arg Lys Arg His Thr Pro Arg Gly 
            420                 425                 430         


Asn Ala Glu Ser Ser Ser Ser Asn Arg Gln Pro Arg Lys Gln Gly 
        435                 440                 445         


<210>  32
<211>  2832
<212>  DNA
<213>  Mus musculus

<400>  32
ggggaaacta gggctgtttg acagcagcag cggcagttcg gggagcgccg gccagagcgc       60

acggaggggc cgtgcggtct ccaccagcgg ccataggacc gcggagcagt tctagcccgc      120

tcgcccgcac gttcgcacac cggatcttcg ccgagtgcca gggcgcagcg cgtggggcgt      180

ctgcctcgct tggtcccctc cagcgtcacc atgctgccgc cacagctgtg ctggctgccg      240

ctgctcgctg ccttgctgcc gccggtgccc gcgcagaagt tctcagcgct cacgttcttg      300

agagtcgatc aagacaaaga cagagactgc agcctggact gcccaagctc ccctcagaag      360

ccactctgtg cctcggacgg gaggaccttc ctgtcccgat gtgagttcca gcgggccaag      420

tgcaaagatc cacagctgga gatcgctcac cgtgggaatt gcaaagatgt gtccaggtgt      480

gtggctgaga ggaagtatac ccaggagcag gcccggaagg agttccagca agtgttcatt      540

ccagaatgca atgatgacgg cacctacagt caggtccagt gtcacagcta cacaggatac      600

tgttggtgtg ttacaccaaa tggaagaccc atcagtggca ctgctgtggc ccacaagaca      660

cccaggtgcc ccggttcaat aaatgaaaag gtgccgcagc gggaaggagc agggaaagca      720

gatgatgctg cagccccagc attggagact cagccccaag gagatgaaga agatattgcc      780

tcacgctacc ctacactctg gaccgagcaa gttaagagtc ggcagaacaa gaccaataaa      840

aattcagcat cctcctgtga tcaggagcat cagtcagctc ttgaggaagc caagcagccc      900

aagaatgaca atgtagtgat ccccgagtgt gcacatggtg gtctctacaa gccagtgcaa      960

tgccatccat ccaccggata ctgctggtgt gtgctagtgg acactggacg gcccattccc     1020

gggacctcca caaggtatga gcaacctaag tgtgacaaca cagcccgagc tcacccagcg     1080

aaggcccggg acctgtacaa gaacaggcca ctgcagggtt gtcctggtgc caaaaagcac     1140

gagtttctga caagtgtcct ggatgcgctc tccacagaca tggttcatgc cgtctctgac     1200

ccctcttcct cttctggcag gctgtcagag ccagacccca gccacaccct ggaggagagg     1260

gttgtacatt ggtacttcaa gctgcttgat aagaactcta gtggagacat tggcaagaag     1320

gagatcaaac cctttaagag gttcctgcga aagaaatcca agcccaaaaa gtgtgtgaag     1380

aagtttgtgg agtactgcga catgaacaat gacaagtcca tcaccgtgca ggagctcatg     1440

ggctgcttgg gtgtcaccag agaggagggt aaagccaaca ccaggaagcg ccacaccccc     1500

agaggaaatg ctgaaagttc ttcttctaat agacagccca ggaaacaagg atgaacggct     1560

gactactcaa gacagttcct agacatgtgg gaattttccc tcaccaaaga gcaattaaaa     1620

acaaaaaaca tatagtattt gcactttgta ctttaaatgt aaattcactt tgtagaaatg     1680

agatatttaa acggactgtt gtgatctgtg aaaacggaag gctggcttcg ggaaattaat     1740

cacatacaat gtatgtgtcc ttgtttgacc ttcaagatct gtgctggtgg ggtgggtttt     1800

aaatgcattt caacttcact tcctcgtccc tctgtggagg gcctggttta ttcccttgcc     1860

ctttcctctg cctgcagtct ccgttggctt gctctccgtg ctcttgatgc cagccagagc     1920

ctaccgtatc cttagaagct tgcagtggtt gcctgtttca taaagttttg ctctctagag     1980

atgtcactca caccatgggt cacacaggca ctagctcagg catagcctta acttccagta     2040

gcccctgctt gagactatgc tgttaggctc cagttttagc ttctgcttga gccaacccta     2100

ctgttaaatc cccggggagc tgaatggaca agcagccaga gagtcctctt tcagagagca     2160

catctaactc tggcctgccg actccatctc attggcccag gaaggatcca gtctacctgc     2220

ctcacttctg agtgcctggg ccatcctgct agggtccact ggaaaggaaa aatgccttct     2280

acagagatca tggaccacat cctgaggaag gcacagctag actacatcgt cccaagagtg     2340

ctgaacaaca ggcagctgag aatgtcaatt tcattttgtg gaggcatcgg gtttgaggga     2400

attcacccaa ggccactatg ggatgaaggt tatgaactgg atgaccatac tgtgagagac     2460

tgaactagat tgggtgtatg gctggctgtc actttctgac ctaggtcagt ctgtactctc     2520

tgttctcaag gaacagtggc agatgggagg agagctgggg caattctttc agattgtggt     2580

ttatatggga aattgttcat ggtccccagc ctctcaatgt atgtctgtag atgcattgtg     2640

aacgcatgct gcagaaggcc tttgctcatt tgaactgtgt agaggcaaga agtgaccggc     2700

tcatgtcaat gctgtctaca aacgagtatg atcctaactg ttttggataa tcttttatat     2760

ttctgaactc tgaatttaat cattttatta gattaaaata tgcgattaaa ttgtgtgagt     2820

cttcttttca gc                                                         2832


<210>  33
<211>  447
<212>  PRT
<213>  Rattus norvegicus

<400>  33

Met Leu Pro Pro Gln Leu Cys Trp Leu Pro Leu Leu Ala Ala Leu Leu 
1               5                   10                  15      


Pro Pro Val Pro Ala Gln Lys Phe Ser Ala Leu Thr Phe Leu Arg Val 
            20                  25                  30          


Asp Gln Asp Lys Asp Arg Asp Cys Ser Leu Asp Cys Pro Ser Ser Pro 
        35                  40                  45              


Gln Lys Pro Leu Cys Ala Ser Asp Gly Arg Thr Phe Leu Ser Arg Cys 
    50                  55                  60                  


Glu Phe Gln Arg Ala Lys Cys Lys Asp Pro Gln Leu Glu Ile Ala His 
65                  70                  75                  80  


Arg Gly Asn Cys Lys Asp Val Ser Arg Cys Val Ala Glu Arg Lys Tyr 
                85                  90                  95      


Thr Gln Glu Gln Ala Arg Lys Glu Phe Gln Gln Val Phe Ile Pro Glu 
            100                 105                 110         


Cys Asn Asp Asp Gly Thr Tyr Ser Gln Val Gln Cys His Ser Tyr Thr 
        115                 120                 125             


Gly Tyr Cys Trp Cys Val Thr Pro Asn Gly Arg Pro Ile Ser Gly Thr 
    130                 135                 140                 


Ala Val Ala His Lys Thr Pro Arg Cys Pro Gly Ser Ile Asn Glu Lys 
145                 150                 155                 160 


Leu Pro Gln Arg Glu Gly Ala Gly Lys Ala Asp Asp Ala Ala Ala Pro 
                165                 170                 175     


Ala Leu Glu Thr Gln Pro Gln Gly Asp Glu Glu Asp Ile Ala Ser Arg 
            180                 185                 190         


Tyr Pro Thr Leu Trp Thr Glu Gln Val Lys Ser Arg Gln Asn Lys Thr 
        195                 200                 205             


Asn Lys Asn Ser Ala Ser Ser Cys Asp Gln Glu His Gln Ser Ala Leu 
    210                 215                 220                 


Glu Glu Ala Lys Gln Pro Lys Asn Asp Asn Val Val Ile Pro Glu Cys 
225                 230                 235                 240 


Ala His Gly Gly Leu Tyr Lys Pro Val Gln Cys His Pro Ser Thr Gly 
                245                 250                 255     


Tyr Cys Trp Cys Val Leu Val Asp Thr Gly Arg Pro Ile Pro Gly Thr 
            260                 265                 270         


Ser Thr Arg Tyr Glu Gln Pro Lys Cys Asp Asn Thr Ala Arg Ala His 
        275                 280                 285             


Pro Ala Lys Ala Arg Asp Leu Tyr Lys Asn Arg Pro Leu Gln Gly Cys 
    290                 295                 300                 


Pro Gly Ala Lys Lys His Glu Phe Leu Thr Ser Val Leu Asp Ala Leu 
305                 310                 315                 320 


Ser Thr Asp Met Val His Ala Val Ser Asp Pro Ser Ser Ser Ser Gly 
                325                 330                 335     


Arg Leu Ser Glu Pro Asp Pro Ser His Thr Leu Glu Glu Arg Val Val 
            340                 345                 350         


His Trp Tyr Phe Lys Leu Leu Asp Lys Asn Ser Ser Gly Asp Ile Gly 
        355                 360                 365             


Lys Lys Glu Ile Lys Pro Phe Lys Arg Phe Leu Arg Lys Lys Ser Lys 
    370                 375                 380                 


Pro Lys Lys Cys Val Lys Lys Phe Val Glu Tyr Cys Asp Met Asn Asn 
385                 390                 395                 400 


Asp Lys Ser Ile Thr Val Gln Glu Leu Met Gly Cys Leu Gly Val Thr 
                405                 410                 415     


Arg Glu Glu Gly Lys Ala Asn Thr Arg Lys Arg His Thr Pro Arg Gly 
            420                 425                 430         


Asn Ala Glu Ser Thr Ser Ser Asn Arg Gln Pro Arg Lys Gln Gly 
        435                 440                 445         


<210>  34
<211>  433
<212>  PRT
<213>  Pan troglodytes

<400>  34

Met Leu Leu Pro Pro Gly Pro Ala Gln Asn Phe Ser Ala Leu Thr Phe 
1               5                   10                  15      


Leu Arg Val Asp Gln Asp Lys Asp Lys Asp Cys Ser Leu Asp Cys Ala 
            20                  25                  30          


Gly Ser Pro Gln Lys Pro Leu Cys Ala Ser Asp Gly Arg Thr Phe Leu 
        35                  40                  45              


Ser Arg Cys Glu Phe Gln Arg Ala Lys Cys Lys Asp Pro Gln Leu Glu 
    50                  55                  60                  


Ile Ala Tyr Arg Gly Asn Cys Lys Asp Val Ser Arg Cys Val Ala Glu 
65                  70                  75                  80  


Arg Lys Tyr Thr Gln Glu Gln Ala Arg Lys Glu Phe Gln Gln Val Phe 
                85                  90                  95      


Ile Pro Glu Cys Asn Asp Asp Gly Thr Tyr Ser Gln Val Gln Cys His 
            100                 105                 110         


Ser Tyr Thr Gly Tyr Cys Trp Cys Val Thr Pro Asn Gly Arg Pro Ile 
        115                 120                 125             


Ser Gly Thr Ala Val Ala His Lys Thr Pro Arg Cys Pro Gly Ser Val 
    130                 135                 140                 


Asn Glu Lys Leu Pro Gln Arg Glu Gly Thr Gly Lys Thr Asp Asp Ala 
145                 150                 155                 160 


Ala Ala Pro Ala Leu Glu Thr Gln Pro Gln Gly Asp Glu Glu Asp Ile 
                165                 170                 175     


Ala Ser Arg Tyr Pro Thr Leu Trp Thr Glu Gln Val Lys Ser Arg Gln 
            180                 185                 190         


Asn Lys Thr Asn Lys Asn Ser Val Ser Ser Cys Asp Gln Glu His Gln 
        195                 200                 205             


Ser Ala Leu Glu Glu Ala Lys Gln Pro Lys Asn Asp Asn Val Val Ile 
    210                 215                 220                 


Pro Glu Cys Ala His Gly Gly Leu Tyr Lys Pro Val Gln Cys His Pro 
225                 230                 235                 240 


Ser Thr Gly Tyr Cys Trp Cys Val Leu Val Asp Thr Gly Arg Pro Ile 
                245                 250                 255     


Pro Gly Thr Ser Thr Arg Tyr Glu Gln Pro Lys Cys Asp Asn Thr Ala 
            260                 265                 270         


Arg Ala His Pro Ala Lys Ala Arg Asp Leu Tyr Lys Gly Arg Gln Leu 
        275                 280                 285             


Gln Gly Cys Pro Gly Ala Lys Lys His Glu Phe Leu Thr Ser Val Leu 
    290                 295                 300                 


Asp Ala Leu Ser Thr Asp Met Val His Ala Val Ser Asp Pro Ser Ser 
305                 310                 315                 320 


Ser Ser Gly Arg Leu Ser Glu Pro Asp Pro Ser His Thr Leu Glu Glu 
                325                 330                 335     


Arg Val Val His Trp Tyr Phe Lys Leu Leu Asp Lys Asn Ser Ser Gly 
            340                 345                 350         


Asp Ile Gly Lys Lys Glu Ile Lys Pro Phe Lys Arg Phe Leu Arg Lys 
        355                 360                 365             


Lys Ser Lys Pro Lys Lys Cys Val Lys Lys Phe Val Glu Tyr Cys Asp 
    370                 375                 380                 


Val Asn Asn Asp Lys Ser Ile Ser Val Gln Glu Leu Met Gly Cys Leu 
385                 390                 395                 400 


Gly Val Ala Lys Glu Asp Gly Lys Ala Asp Thr Lys Lys Arg His Thr 
                405                 410                 415     


Pro Arg Gly Asn Ala Glu Ser Thr Ser Asn Arg Gln Pro Arg Lys Gln 
            420                 425                 430         


Gly 
    


<210>  35
<211>  436
<212>  PRT
<213>  Canis lupus familiaris

<400>  35

Met Leu Leu Pro Gln Leu Cys Trp Leu Pro Leu Leu Ala Gly Leu Leu 
1               5                   10                  15      


Pro Pro Ala Pro Ala Gln Lys Phe Ser Ala Leu Thr Phe Leu Arg Val 
            20                  25                  30          


Asp Gln Asp Lys Asp Lys Asp Cys Ser Leu Asp Cys Gly Gly Ser Ser 
        35                  40                  45              


Gln Lys Pro Leu Cys Ala Ser Asp Gly Arg Thr Phe Leu Ser Arg Cys 
    50                  55                  60                  


Glu Phe Gln Arg Ala Lys Cys Lys Asp Pro Gln Leu Glu Ile Ala Tyr 
65                  70                  75                  80  


Arg Gly Asn Cys Arg Asp Val Ser Arg Cys Val Ala Glu Arg Lys Tyr 
                85                  90                  95      


Thr Gln Glu Gln Ala Arg Lys Glu Leu Gln Gln Val Phe Ile Pro Glu 
            100                 105                 110         


Cys Asn Asp Asp Gly Thr Tyr Ser Gln Val Gln Cys His Ser Tyr Thr 
        115                 120                 125             


Gly Tyr Cys Trp Cys Val Thr Pro Asn Gly Arg Pro Val Ser Gly Thr 
    130                 135                 140                 


Ala Val Ala His Lys Thr Pro Arg Cys Pro Gly Ser Ile Asn Glu Lys 
145                 150                 155                 160 


Leu Pro Gln Arg Glu Gly Thr Gly Lys Thr Asp Asp Ala Ser Ala Pro 
                165                 170                 175     


Ala Leu Glu Thr Gln Pro Gln Gly Asp Glu Glu Asp Ile Ala Ser Arg 
            180                 185                 190         


Tyr Pro Thr Leu Trp Thr Glu Gln Val Lys Ser Arg Gln Asn Lys Thr 
        195                 200                 205             


Asn Lys Asn Ser Val Ser Ser Cys Asp Gln Glu Gln Gln Ser Ala Leu 
    210                 215                 220                 


Glu Glu Ala Arg Gln Pro Lys Asn Asp Asn Val Val Ile Pro Glu Cys 
225                 230                 235                 240 


Ala His Gly Gly Leu Tyr Lys Pro Val Gln Cys His Pro Ser Thr Gly 
                245                 250                 255     


Tyr Cys Trp Cys Val Leu Val Asp Thr Gly Arg Pro Ile Pro Gly Thr 
            260                 265                 270         


Ser Thr Arg Tyr Glu Gln Pro Lys Cys Asp Asn Thr Ala Arg Ala His 
        275                 280                 285             


Pro Thr Lys Thr Arg Asp Leu Tyr Lys Gly Arg Gln Leu Gln Gly Cys 
    290                 295                 300                 


Pro Gly Ala Lys Lys Asn Glu Phe Leu Thr Ser Ile Leu Asp Ala Leu 
305                 310                 315                 320 


Ser Thr Asp Met Val His Ala Val Ser Asp Pro Ser Ser Ser Gly Arg 
                325                 330                 335     


Leu Ser Glu Pro Asp Pro Ser His Thr Leu Glu Glu Arg Val Val His 
            340                 345                 350         


Trp Tyr Phe Lys Leu Leu Asp Lys Asn Ser Ser Gly Asp Ile Gly Lys 
        355                 360                 365             


Lys Glu Ile Lys Pro Phe Lys Arg Phe Leu Arg Lys Lys Ser Lys Pro 
    370                 375                 380                 


Lys Lys Cys Val Lys Lys Phe Val Glu Tyr Cys Asp Val Asn Asn Asp 
385                 390                 395                 400 


Lys Ser Ile Ser Val Gln Glu Leu Met Gly Cys Leu Gly Val Thr Lys 
                405                 410                 415     


Glu Glu Ala Pro Arg Ala Asn Ala Glu Ser Ala Ser Asn Arg Gln Pro 
            420                 425                 430         


Arg Lys Gln Gly 
        435     


<210>  36
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is R or K.

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is T or I.

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is P or S.

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is A or S.

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  In some cases, the C-terminal residue is modified to comprise a 
       CONH2 group instead of a carboxyl group.

<400>  36

Xaa Asp Xaa Thr Val Lys Xaa Gly Xaa 
1               5                   


<210>  37
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is N or H.

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is I or V.

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  In some cases, the C-terminal residue is modified to comprise a 
       CONH2 group instead of a carboxyl group.

<400>  37

Val Phe Ala Glu Xaa Lys Glu Ile Gln Lys Leu Ala Glu Gln Phe Val 
1               5                   10                  15      


Leu Leu Asn Leu Xaa Tyr Glu Thr Thr Asp 
            20                  25      


<210>  38
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is I, L, M or V.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is V. In some cases, the amino acid at this position is 
       absent.

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  In some cases, the C-terminal residue is modified to comprise a 
       CONH2 group instead of a carboxyl group.

<400>  38

Ile Xaa Phe Xaa Val Asp Pro Ser Leu Thr Val Arg Ala Asp Ile Thr 
1               5                   10                  15      


Gly 
    


<210>  39
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is I, L, M or V.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is V. In some cases, the amino acid at this position is 
       absent.

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  In some cases, the C-terminal residue is modified to comprise a 
       CONH2 group instead of a carboxyl group.

<400>  39

Ile Xaa Phe Xaa Val Asp Pro Ser Leu Thr Val Arg Ala Asp Ile Thr 
1               5                   10                  15      


<210>  40
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is A or S.

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is T or I.

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is H, Y or L.

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  In some cases, the C-terminal residue is modified to comprise a 
       CONH2 group instead of a carboxyl group.

<400>  40

Leu Tyr Ala Tyr Glu Pro Xaa Asp Xaa Ala Leu Leu Xaa Asp Asn Met 
1               5                   10                  15      


<210>  41
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is A or S.

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is T or I.

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is H, Y or L.

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  In some cases, the C-terminal residue is modified to comprise a 
       CONH2 group instead of a carboxyl group.

<400>  41

Tyr Ser Asn Arg Leu Tyr Ala Tyr Glu Pro Xaa Asp Xaa Ala Leu Leu 
1               5                   10                  15      


Xaa Asp Asn Met 
            20  


<210>  42
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is G or E.

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is M, A or T.

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is L, T or S.

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is E. In some cases, the amino acid at this position is 
       absent.

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is D or E.

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is D or A.

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is T, L or M.

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is E or A.

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is E or A.

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  In some cases, the C-terminal residue is modified to comprise a 
       CONH2 group instead of a carboxyl group.

<400>  42

Xaa Xaa Xaa Lys Glu Xaa Xaa Xaa Asp Thr Glu Arg Leu Pro Ser Lys 
1               5                   10                  15      


Cys Glu Val Cys Lys Leu Leu Ser Xaa Glu Leu Gln Xaa Xaa Leu Ser 
            20                  25                  30          


Arg Thr 
        


<210>  43
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is S or P.

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is F, L or Y.

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is K, Q or R.

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is E or D.

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is V or A.

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  In some cases, the C-terminal residue is modified to comprise a 
       CONH2 group instead of a carboxyl group.

<400>  43

Gln Ser Ile Arg Ser Xaa Pro Xaa Asp Asn Xaa Leu Asn Val Xaa Asp 
1               5                   10                  15      


Xaa Asp Ser Thr Lys Asn 
            20          


<210>  44
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is V or M.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is S or T.

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is T or A.

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is R or K.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is E or D.

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  In some cases, the C-terminal residue is modified to comprise a 
       CONH2 group instead of a carboxyl group.

<400>  44

Cys Val Lys Lys Phe Val Glu Tyr Cys Asp Xaa Asn Asn Asp Lys Ser 
1               5                   10                  15      


Ile Xaa Val Gln Glu Leu Met Gly Cys Leu Gly Val Xaa Xaa Glu Xaa 
            20                  25                  30          


Gly 
    


<210>  45
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  45

Arg Asp Thr Thr Val Lys Pro Gly Ala 
1               5                   


<210>  46
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  46

Val Phe Ala Glu Asn Lys Glu Ile Gln Lys Leu Ala Glu Gln Phe Val 
1               5                   10                  15      


Leu Leu Asn Leu Val Tyr Glu Thr Thr Asp 
            20                  25      


<210>  47
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  47

Ile Met Phe Val Asp Pro Ser Leu Thr Val Arg Ala Asp Ile Thr Gly 
1               5                   10                  15      


<210>  48
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is modified to comprise a CONH2 group instead of a carboxyl 
       group.

<400>  48

Ile Met Phe Val Asp Pro Ser Leu Thr Val Arg Ala Asp Ile Thr 
1               5                   10                  15  


<210>  49
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  49

Leu Tyr Ala Tyr Glu Pro Ala Asp Thr Ala Leu Leu Leu Asp Asn Met 
1               5                   10                  15      


<210>  50
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  50

Tyr Ser Asn Arg Leu Tyr Ala Tyr Glu Pro Ala Asp Thr Ala Leu Leu 
1               5                   10                  15      


Leu Asp Asn Met 
            20  


<210>  51
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  51

Gly Met Leu Lys Glu Glu Asp Asp Asp Thr Glu Arg Leu Pro Ser Lys 
1               5                   10                  15      


Cys Glu Val Cys Lys Leu Leu Ser Thr Glu Leu Gln Ala Glu Leu Ser 
            20                  25                  30          


Arg Thr 
        


<210>  52
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  52

Glu Ala Thr Lys Glu Glu Glu Asp Asp Thr Glu Arg Leu Pro Ser Lys 
1               5                   10                  15      


Cys Glu Val Cys Lys Leu Leu Ser Met Glu Leu Gln Glu Ala Leu Ser 
            20                  25                  30          


Arg Thr 
        


<210>  53
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  53

Gln Ser Ile Arg Ser Ser Pro Leu Asp Asn Lys Leu Asn Val Glu Asp 
1               5                   10                  15      


Val Asp Ser Thr Lys Asn 
            20          


<210>  54
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  54

Gln Ser Ile Arg Ser Pro Pro Phe Asp Asn Gln Leu Asn Val Glu Asp 
1               5                   10                  15      


Ala Asp Ser Thr Lys Asn 
            20          


<210>  55
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  55

Cys Val Lys Lys Phe Val Glu Tyr Cys Asp Val Asn Asn Asp Lys Ser 
1               5                   10                  15      


Ile Ser Val Gln Glu Leu Met Gly Cys Leu Gly Val Ala Lys Glu Asp 
            20                  25                  30          


Gly 
    


<210>  56
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  56

Cys Val Lys Lys Phe Val Glu Tyr Cys Asp Met Asn Asn Asp Lys Ser 
1               5                   10                  15      


Ile Thr Val Gln Glu Leu Met Gly Cys Leu Gly Val Thr Arg Glu Glu 
            20                  25                  30          


Gly 
    


<210>  57
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  57

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  58
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  58

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  59
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  59

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  60
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  60

Lys Ala Leu Ala Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala 
1               5                   10                  15      


Leu Ala Lys His Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu 
            20                  25                  30          


Ala 
    


<210>  61
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  61

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  62
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  62

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  63
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  63

Arg Lys Lys Arg Arg Gln Arg Arg 
1               5               


<210>  64
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  64

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  65
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  65

Thr His Arg Leu Pro Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  66
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  66

Gly Gly Arg Arg Ala Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  67
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  67

Gly Ser Gly Gly Ser 
1               5   


<210>  68
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  68

Gly Gly Gly Ser 
1               


<210>  69
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  69

Gly Gly Ser Gly 
1               


<210>  70
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  70

Gly Gly Ser Gly Gly 
1               5   


<210>  71
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  71

Gly Ser Gly Ser Gly 
1               5   


<210>  72
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  72

Gly Ser Gly Gly Gly 
1               5   


<210>  73
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  73

Gly Gly Gly Ser Gly 
1               5   


<210>  74
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  74

Gly Ser Ser Ser Gly 
1               5   


