                         SEQUENCE LISTING

<110>  Kaplan, Daniel  D
       Saberi, Maziyar
 
<120>  METHODS OF TREATING GLUCOSE METABOLISM DISORDERS

<130>  NGMB-0128WO

<150>  US 61/672,667
<151>  2012-07-17

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Tyr Leu Leu Met Ile Phe Ser Leu Leu Phe Val Ala Cys Gln 
1               5                   10                  15      


Gly Ala Pro Glu Thr Ala Val Leu Gly Ala Glu Leu Ser Ala Val Gly 
            20                  25                  30          


Glu Asn Gly Gly Glu Lys Pro Thr Pro Ser Pro Pro Trp Arg Leu Arg 
        35                  40                  45              


Arg Ser Lys Arg Cys Ser Cys Ser Ser Leu Met Asp Lys Glu Cys Val 
    50                  55                  60                  


Tyr Phe Cys His Leu Asp Ile Ile Trp Val Asn Thr Pro Glu His Val 
65                  70                  75                  80  


Val Pro Tyr Gly Leu Gly Ser Pro Arg Ser Lys Arg Ala Leu Glu Asn 
                85                  90                  95      


Leu Leu Pro Thr Lys Ala Thr Asp Arg Glu Asn Arg Cys Gln Cys Ala 
            100                 105                 110         


Ser Gln Lys Asp Lys Lys Cys Trp Asn Phe Cys Gln Ala Gly Lys Glu 
        115                 120                 125             


Leu Arg Ala Glu Asp Ile Met Glu Lys Asp Trp Asn Asn His Lys Lys 
    130                 135                 140                 


Gly Lys Asp Cys Ser Lys Leu Gly Lys Lys Cys Ile Tyr Gln Gln Leu 
145                 150                 155                 160 


Val Arg Gly Arg Lys Ile Arg Arg Ser Ser Glu Glu His Leu Arg Gln 
                165                 170                 175     


Thr Arg Ser Glu Thr Met Arg Asn Ser Val Lys Ser Ser Phe His Asp 
            180                 185                 190         


Pro Lys Leu Lys Gly Lys Pro Ser Arg Glu Arg Tyr Val Thr His Asn 
        195                 200                 205             


Arg Ala His Trp 
    210         


<210>  2
<211>  2112
<212>  DNA
<213>  Homo sapiens

<400>  2
ggagctgttt acccccactc taataggggt tcaatataaa aagccggcag agagctgtcc       60

aagtcagacg cgcctctgca tctgcgccag gcgaacgggt cctgcgcctc ctgcagtccc      120

agctctccac cgccgcgtgc gcctgcagac gctccgctcg ctgccttctc tcctggcagg      180

cgctgccttt tctccccgtt aaaagggcac ttgggctgaa ggatcgcttt gagatctgag      240

gaacccgcag cgctttgagg gacctgaagc tgtttttctt cgttttcctt tgggttcagt      300

ttgaacggga ggtttttgat cccttttttt cagaatggat tatttgctca tgattttctc      360

tctgctgttt gtggcttgcc aaggagctcc agaaacagca gtcttaggcg ctgagctcag      420

cgcggtgggt gagaacggcg gggagaaacc cactcccagt ccaccctggc ggctccgccg      480

gtccaagcgc tgctcctgct cgtccctgat ggataaagag tgtgtctact tctgccacct      540

ggacatcatt tgggtcaaca ctcccgagca cgttgttccg tatggacttg gaagccctag      600

gtccaagaga gccttggaga atttacttcc cacaaaggca acagaccgtg aaaatagatg      660

ccaatgtgct agccaaaaag acaagaagtg ctggaatttt tgccaagcag gaaaagaact      720

cagggctgaa gacattatgg agaaagactg gaataatcat aagaaaggaa aagactgttc      780

caagcttggg aaaaagtgta tttatcagca gttagtgaga ggaagaaaaa tcagaagaag      840

ttcagaggaa cacctaagac aaaccaggtc ggagaccatg agaaacagcg tcaaatcatc      900

ttttcatgat cccaagctga aaggcaagcc ctccagagag cgttatgtga cccacaaccg      960

agcacattgg tgacagacct tcggggcctg tctgaagcca tagcctccac ggagagccct     1020

gtggccgact ctgcactctc caccctggct gggatcagag caggagcatc ctctgctggt     1080

tcctgactgg caaaggacca gcgtcctcgt tcaaaacatt ccaagaaagg ttaaggagtt     1140

cccccaacca tcttcactgg cttccatcag tggtaactgc tttggtctct tctttcatct     1200

ggggatgaca atggacctct cagcagaaac acacagtcac attcgaattc gggtggcatc     1260

ctccggagag agagagagga aggagattcc acacaggggt ggagtttctg acgaaggtcc     1320

taagggagtg tttgtgtctg actcaggcgc ctggcacatt tcagggagaa actccaaagt     1380

ccacacaaag attttctaag gaatgcacaa attgaaaaca cactcaaaag acaaacatgc     1440

aagtaaagaa aaaaaaaaga aagacttttg tttaaatttg taaaatgcaa aactgaatga     1500

aactgttact accataaatc aggatatgtt tcatgaatat gagtctacct cacctatatt     1560

gcactctggc agaagtattt cccacattta attattgcct ccccaaactc ttcccacccc     1620

tgctgcccct tcctccatcc cccatactaa atcctagcct cgtagaagtc tggtctaatg     1680

tgtcagcagt agatataata ttttcatggt aatctactag ctctgatcca taagaaaaaa     1740

aagatcatta aatcaggaga ttccctgtcc ttgatttttg gagacacaat ggtatagggt     1800

tgtttatgaa atatattgaa aagtaagtgt ttgttacgct ttaaagcagt aaaattattt     1860

tcctttatat aaccggctaa tgaaagaggt tggattgaat tttgatgtac ttattttttt     1920

atagatattt atattcaaac aatttattcc ttatatttac catgttaaat atctgtttgg     1980

gcaggccata ttggtctatg tatttttaaa atatgtattt ctaaatgaaa ttgagaacat     2040

gctttgtttt gcctgtcaag gtaatgactt tagaaaataa atattttttt ccttactgta     2100

aaaaaaaaaa aa                                                         2112


<210>  3
<211>  202
<212>  PRT
<213>  Mus musculus

<400>  3

Met Asp Tyr Phe Pro Val Ile Phe Ser Leu Leu Phe Val Thr Phe Gln 
1               5                   10                  15      


Gly Ala Pro Glu Thr Ala Val Leu Gly Ala Glu Leu Ser Thr Gly Ala 
            20                  25                  30          


Glu Asn Gly Val Gln Ser Pro Pro Pro Ser Thr Pro Trp Arg Pro Arg 
        35                  40                  45              


Arg Ser Lys Arg Cys Ser Cys Ser Ser Leu Met Asp Lys Glu Cys Val 
    50                  55                  60                  


Tyr Phe Cys His Leu Asp Ile Ile Trp Val Asn Thr Pro Glu Arg Val 
65                  70                  75                  80  


Val Pro Tyr Gly Leu Gly Gly Ser Ser Arg Ser Lys Arg Ser Leu Lys 
                85                  90                  95      


Asp Leu Leu Pro Asn Lys Ala Thr Asp Gln Ala Val Arg Cys Gln Cys 
            100                 105                 110         


Ala His Gln Lys Asp Lys Lys Cys Trp Asn Phe Cys Gln Ala Gly Lys 
        115                 120                 125             


Glu Leu Arg Ala Gln Ser Thr Met Gln Lys Ser Leu Lys Asp Ser Lys 
    130                 135                 140                 


Lys Gly Lys Pro Cys Ser Lys Leu Gly Lys Lys Cys Ile Tyr Gln Gln 
145                 150                 155                 160 


Leu Val Glu Gly Arg Lys Leu Arg Arg Leu Glu Ala Ile Ser Asn Ser 
                165                 170                 175     


Ile Lys Ala Ser Phe Arg Val Ala Lys Leu Lys Ala Glu Leu Tyr Arg 
            180                 185                 190         


Asp Gln Lys Leu Thr His Asn Arg Ala His 
        195                 200         


<210>  4
<211>  2344
<212>  DNA
<213>  Mus musculus

<400>  4
attccaatgg ggtgactttg cttctggaga aactcttgat tcttgaactc tggggctggc       60

agctagcaaa aggggaagcg ggctgctgct ctctgcaggt tctgcagcgg tctctgtcta      120

gtgggtgttt tctttttctt agccctgccc ctggattgtc agacggcggg cgtctgcctc      180

tgaagttagc cgtgatttcc tctagagccg ggtcttatct ctggctgcac gttgcctgtg      240

ggtgactaat cacacaataa cattgtttag ggctggaata aagtcagagc tgtttacccc      300

cactctatag gggttcaata taaaaaggcg gcggagaact gtccgagtca gaagcgttcc      360

tgcaccggcg ctgagagcct gacccggtct gctccgctgt ccttgcgcgc tgcctcccgg      420

ctgcccgcga cgctttcgcc ccagtggaag ggccacttgc tgaggaccgc gctgagatct      480

aaaaaaaaaa caaaaaacaa aaaacaaaaa aacccagagg cgatcagagc gaccagacac      540

cgtcctcttc gttttgcatt gagttccatt tgcaaccgag ttttcttttt ttcctttttc      600

cccactcttc tgaccccttt gcagaatgga ttattttccc gtgatcttct ctctgctgtt      660

cgtgactttc caaggagctc cagaaacagc tgtcttggga gccgaactca gcaccggagc      720

tgagaatgga gtgcagagcc cccctcccag cacaccctgg agaccccgca ggtccaagcg      780

ctgttcctgt tcttccttga tggacaagga gtgtgtctac ttctgccacc tggacatcat      840

ctgggtcaac actcccgagc gcgtcgtacc gtatggactg ggaggttctt ccaggtccaa      900

gcgttccttg aaagacttac ttcccaataa ggccacagac caggcagtta gatgtcagtg      960

cgctcaccaa aaagacaaga agtgctggaa tttctgccaa gcaggaaaag aactcagggc     1020

ccaaagtacc atgcagaaaa gcttaaaaga ctccaagaaa ggaaaaccct gttccaagtt     1080

gggaaagaag tgtatctatc agcagctggt ggaaggaagg aaactacgaa ggttggaggc     1140

catcagcaat agcatcaagg catcttttcg tgttgcaaag ttgaaagctg agctctatag     1200

agaccagaag ttgacgcaca accgagcaca ttgactacag agctccccca gtgttttgga     1260

agtcatccct tatatagtgc gagccccatg gccagctctg cactctccat gctggctggg     1320

atcttagcaa gaccatctgt gtggcttcta cagtttcttg ttcagacggg cagaggacca     1380

gcatccttga tccaaacatt ccaagaaagg ctgaggtgtt ccctagcctg tctgcgtccg     1440

ctgggagcga gtgcctttct gcctcttctt gccggttggg aatgacagag gacttctcag     1500

agagcagaga cacgatgcca ttctagagtg gcatcactca gagagccagg agattccaca     1560

gcagggcggg gtttctgtag aaagtcctta gggagtgttc gtgtctgact caggcgcctg     1620

gcacatttca gggagaaact ccaaagtcca tgcaaaaatt tttctgagga atgcacaaat     1680

tgaaaacata ctcgaaggac aaacacttga gtttaaaaaa aaaaaaaaga caatttttaa     1740

gttgtaaaat gcaaaactca aagcaactgt tactactgta cattgggatg tatttcatga     1800

atatgagtct acctcacctt tctgcactgt catacacatt ctcaccttta attattgcct     1860

ccctgtattc tctcctctcc gctatccggg ttcccagtcc cctatactga atccttgcct     1920

cacagaaatt gagtcagaag tagctgaaac attgccatgc taatctgcta gctctaatct     1980

atgagaaaaa aggatgacag aatctggccc ctgcccttga ccttgggaaa cacaatggtt     2040

tagagttgtt tgtgtacatg ttgaaaacct ggtctgtgct ttttagcagt aaaaatatgt     2100

tcccgtatgt attgtaactg gctaatggaa gaggttagat tgaatcttga tgtacttatt     2160

tttttataga tatttatatt caaacaattt attccttata tttaccatgt taaatatatg     2220

tctgggcagg ccatattggt ctatgtattt tttaaaaata tatatttctg aatgaaattg     2280

agaacatgct ttgttttgcc tgtcaaggta atgattttag aaaataaata tttttcccta     2340

ctgt                                                                  2344


<210>  5
<211>  202
<212>  PRT
<213>  Rattus norvegicus

<400>  5

Met Asp Tyr Phe Pro Val Ile Phe Ser Leu Leu Phe Val Ala Phe Gln 
1               5                   10                  15      


Gly Ala Pro Glu Thr Ala Val Leu Gly Ala Glu Leu Ser Pro Arg Ala 
            20                  25                  30          


Glu Lys Glu Val Gln Ser Pro Pro Pro Ser Thr Ser Trp Arg Pro Arg 
        35                  40                  45              


Arg Ser Lys Arg Cys Ser Cys Ser Ser Leu Met Asp Lys Glu Cys Val 
    50                  55                  60                  


Tyr Phe Cys His Leu Asp Ile Ile Trp Val Asn Thr Pro Glu Arg Val 
65                  70                  75                  80  


Val Pro Tyr Gly Leu Gly Ser Pro Ser Arg Ser Lys Arg Ser Leu Lys 
                85                  90                  95      


Asp Leu Leu Pro Thr Lys Thr Thr Asp Gln Gly Asn Arg Cys Gln Cys 
            100                 105                 110         


Ala His Gln Lys Asp Lys Lys Cys Trp Asn Phe Cys Gln Ala Asp Lys 
        115                 120                 125             


Glu Leu Arg Ala Gln Ser Thr Met Gln Lys Gly Val Lys Asp Phe Lys 
    130                 135                 140                 


Lys Gly Lys Pro Cys Pro Lys Leu Gly Lys Lys Cys Ile Tyr Gln Gln 
145                 150                 155                 160 


Leu Val Glu Gly Arg Lys Leu Arg Arg Leu Glu Ala Ile Ser Asn Ser 
                165                 170                 175     


Ile Lys Thr Ser Phe Arg Val Ala Lys Leu Lys Ala Glu Leu Tyr Arg 
            180                 185                 190         


Asp Gln Lys Leu Ile His Asn Arg Ala His 
        195                 200         


<210>  6
<211>  202
<212>  PRT
<213>  Canis lupus familiaris

<400>  6

Met Asp Tyr Phe Pro Met Ile Phe Ser Leu Leu Phe Val Ala Phe Gln 
1               5                   10                  15      


Gly Ala Pro Glu Ala Ala Val Leu Gly Ala Glu Leu Ser Thr Gly Pro 
            20                  25                  30          


Asp Ser Arg Gly Glu Lys Pro Ala Pro Ser Ala Pro Trp Arg Pro Arg 
        35                  40                  45              


Arg Ser Lys Arg Cys Ser Cys Ser Ser Leu Met Asp Lys Glu Cys Val 
    50                  55                  60                  


Tyr Phe Cys His Leu Asp Ile Ile Trp Val Asn Thr Pro Glu His Ile 
65                  70                  75                  80  


Val Pro Tyr Gly Leu Gly Ser Pro Ser Arg Ser Lys Arg Ser Leu Lys 
                85                  90                  95      


Asp Leu Phe Ile Thr Lys Ala Thr Asp His Arg Lys Arg Cys Gln Cys 
            100                 105                 110         


Ala Ser Gln Lys Asp Lys Lys Cys Trp Thr Phe Cys Gln Ala Gly Lys 
        115                 120                 125             


Glu Leu Arg Glu Gln Asp Ser Met Glu Lys Gly Trp Asn Gly His Lys 
    130                 135                 140                 


Lys Gly Lys Asp Cys Ser Glu Leu Gly Glu Lys Ser Lys Gln Gln Gln 
145                 150                 155                 160 


Leu Val Ala Gly Arg Lys Ile Arg Arg Leu Asp Ala Ile Ser Asn Ser 
                165                 170                 175     


Ile Lys Thr Ala Phe Arg Val Ala Lys Leu Lys Ala Glu Leu Tyr Arg 
            180                 185                 190         


Glu Asn Lys Val Thr His Asn Arg Thr His 
        195                 200         


<210>  7
<211>  212
<212>  PRT
<213>  Pan troglodytes

<400>  7

Met Asp Tyr Leu Pro Met Ile Phe Ser Leu Leu Phe Val Ala Cys Gln 
1               5                   10                  15      


Gly Ala Pro Glu Thr Ala Val Leu Gly Ala Glu Leu Ser Val Ala Gly 
            20                  25                  30          


Glu Asp Gly Gly Glu Lys Pro Thr Pro Ser Pro Pro Trp Arg Leu Arg 
        35                  40                  45              


Arg Ser Lys Arg Cys Ser Cys Ser Ser Leu Met Asp Lys Glu Cys Val 
    50                  55                  60                  


Tyr Phe Cys His Leu Asp Ile Ile Trp Val Asn Thr Pro Glu His Val 
65                  70                  75                  80  


Val Pro Tyr Gly Leu Gly Ser Pro Arg Ser Lys Arg Ala Leu Glu Asn 
                85                  90                  95      


Leu Leu Pro Thr Lys Ala Thr Asp Arg Glu Asn Arg Cys Gln Cys Ala 
            100                 105                 110         


Asn Gln Lys Asp Lys Lys Cys Trp Asn Phe Cys Gln Ala Gly Lys Glu 
        115                 120                 125             


Leu Arg Ala Glu Asp Ile Met Glu Lys Asp Trp Asn Asn His Lys Lys 
    130                 135                 140                 


Gly Lys Asp Cys Ser Lys Leu Gly Lys Lys Cys Ile Tyr Gln Gln Leu 
145                 150                 155                 160 


Val Arg Gly Arg Lys Ile Arg Arg Ser Ser Glu Glu His Leu Arg Gln 
                165                 170                 175     


Thr Arg Ser Glu Thr Met Lys Asn Ser Val Lys Ser Ser Phe His Asp 
            180                 185                 190         


Pro Lys Leu Lys Gly Glu Pro Ser Arg Glu Arg Tyr Ala Thr His Asn 
        195                 200                 205             


Arg Ala His Trp 
    210         


<210>  8
<211>  560
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Phe Ala Arg Met Ser Asp Leu His Val Leu Leu Leu Met Ala Leu 
1               5                   10                  15      


Val Gly Lys Thr Ala Cys Gly Phe Ser Leu Met Ser Leu Leu Glu Ser 
            20                  25                  30          


Leu Asp Pro Asp Trp Thr Pro Asp Gln Tyr Asp Tyr Ser Tyr Glu Asp 
        35                  40                  45              


Tyr Asn Gln Glu Glu Asn Thr Ser Ser Thr Leu Thr His Ala Glu Asn 
    50                  55                  60                  


Pro Asp Trp Tyr Tyr Thr Glu Asp Gln Ala Asp Pro Cys Gln Pro Asn 
65                  70                  75                  80  


Pro Cys Glu His Gly Gly Asp Cys Leu Val His Gly Ser Thr Phe Thr 
                85                  90                  95      


Cys Ser Cys Leu Ala Pro Phe Ser Gly Asn Lys Cys Gln Lys Val Gln 
            100                 105                 110         


Asn Thr Cys Lys Asp Asn Pro Cys Gly Arg Gly Gln Cys Leu Ile Thr 
        115                 120                 125             


Gln Ser Pro Pro Tyr Tyr Arg Cys Val Cys Lys His Pro Tyr Thr Gly 
    130                 135                 140                 


Pro Ser Cys Ser Gln Val Val Pro Val Cys Arg Pro Asn Pro Cys Gln 
145                 150                 155                 160 


Asn Gly Ala Thr Cys Ser Arg His Lys Arg Arg Ser Lys Phe Thr Cys 
                165                 170                 175     


Ala Cys Pro Asp Gln Phe Lys Gly Lys Phe Cys Glu Ile Gly Ser Asp 
            180                 185                 190         


Asp Cys Tyr Val Gly Asp Gly Tyr Ser Tyr Arg Gly Lys Met Asn Arg 
        195                 200                 205             


Thr Val Asn Gln His Ala Cys Leu Tyr Trp Asn Ser His Leu Leu Leu 
    210                 215                 220                 


Gln Glu Asn Tyr Asn Met Phe Met Glu Asp Ala Glu Thr His Gly Ile 
225                 230                 235                 240 


Gly Glu His Asn Phe Cys Arg Asn Pro Asp Ala Asp Glu Lys Pro Trp 
                245                 250                 255     


Cys Phe Ile Lys Val Thr Asn Asp Lys Val Lys Trp Glu Tyr Cys Asp 
            260                 265                 270         


Val Ser Ala Cys Ser Ala Gln Asp Val Ala Tyr Pro Glu Glu Ser Pro 
        275                 280                 285             


Thr Glu Pro Ser Thr Lys Leu Pro Gly Phe Asp Ser Cys Gly Lys Thr 
    290                 295                 300                 


Glu Ile Ala Glu Arg Lys Ile Lys Arg Ile Tyr Gly Gly Phe Lys Ser 
305                 310                 315                 320 


Thr Ala Gly Lys His Pro Trp Gln Ala Ser Leu Gln Ser Ser Leu Pro 
                325                 330                 335     


Leu Thr Ile Ser Met Pro Gln Gly His Phe Cys Gly Gly Ala Leu Ile 
            340                 345                 350         


His Pro Cys Trp Val Leu Thr Ala Ala His Cys Thr Asp Ile Lys Thr 
        355                 360                 365             


Arg His Leu Lys Val Val Leu Gly Asp Gln Asp Leu Lys Lys Glu Glu 
    370                 375                 380                 


Phe His Glu Gln Ser Phe Arg Val Glu Lys Ile Phe Lys Tyr Ser His 
385                 390                 395                 400 


Tyr Asn Glu Arg Asp Glu Ile Pro His Asn Asp Ile Ala Leu Leu Lys 
                405                 410                 415     


Leu Lys Pro Val Asp Gly His Cys Ala Leu Glu Ser Lys Tyr Val Lys 
            420                 425                 430         


Thr Val Cys Leu Pro Asp Gly Ser Phe Pro Ser Gly Ser Glu Cys His 
        435                 440                 445             


Ile Ser Gly Trp Gly Val Thr Glu Thr Gly Lys Gly Ser Arg Gln Leu 
    450                 455                 460                 


Leu Asp Ala Lys Val Lys Leu Ile Ala Asn Thr Leu Cys Asn Ser Arg 
465                 470                 475                 480 


Gln Leu Tyr Asp His Met Ile Asp Asp Ser Met Ile Cys Ala Gly Asn 
                485                 490                 495     


Leu Gln Lys Pro Gly Gln Asp Thr Cys Gln Gly Asp Ser Gly Gly Pro 
            500                 505                 510         


Leu Thr Cys Glu Lys Asp Gly Thr Tyr Tyr Val Tyr Gly Ile Val Ser 
        515                 520                 525             


Trp Gly Leu Glu Cys Gly Lys Arg Pro Gly Val Tyr Thr Gln Val Thr 
    530                 535                 540                 


Lys Phe Leu Asn Trp Ile Lys Ala Thr Ile Lys Ser Glu Ser Gly Phe 
545                 550                 555                 560 


<210>  9
<211>  3019
<212>  DNA
<213>  Homo sapiens

<400>  9
atttgttcct gaatccttgg agactgacat ttttcccccc taaaggcata gacaacaaaa       60

gaaattttat tgagaggaaa acacaagtcc ttaaactgca aagatgtttg ccaggatgtc      120

tgatctccat gttctgctgt taatggctct ggtgggaaag acagcctgtg ggttctccct      180

gatgtcttta ttggaaagcc tggacccaga ctggacccct gaccagtatg attacagcta      240

cgaggattat aatcaggaag agaacaccag tagcacactt acccacgctg agaatcctga      300

ctggtactac actgaggacc aagctgatcc atgccagccc aacccctgtg aacacggtgg      360

ggactgcctc gtccatggga gcaccttcac atgcagctgc ctggctcctt tctctgggaa      420

taagtgtcag aaagtgcaaa atacgtgcaa ggacaaccca tgtggccggg gccaatgtct      480

cattacccag agtcctccct actaccgctg tgtctgtaaa cacccttaca caggtcccag      540

ctgctcccaa gtggttcctg tatgcaggcc aaacccctgc cagaatgggg ctacctgctc      600

ccggcataag cggagatcca agttcacctg tgcctgtccc gaccagttca aggggaaatt      660

ctgtgaaata ggttctgatg actgctatgt tggcgatggc tactcttacc gagggaaaat      720

gaataggaca gtcaaccagc atgcgtgcct ttactggaac tcccacctcc tcttgcagga      780

gaattacaac atgtttatgg aggatgctga aacccatggg attggggaac acaatttctg      840

cagaaaccca gatgcggacg aaaagccctg gtgctttatt aaagttacca atgacaaggt      900

gaaatgggaa tactgtgatg tctcagcctg ctcagcccag gacgttgcct acccagagga      960

aagccccact gagccatcaa ccaagcttcc ggggtttgac tcctgtggaa agactgagat     1020

agcagagagg aagatcaaga gaatctatgg aggctttaag agcacggcgg gcaagcaccc     1080

atggcaggcg tccctccagt cctcgctgcc tctgaccatc tccatgcccc agggccactt     1140

ctgtggtggg gcgctgatcc acccctgctg ggtgctcact gctgcccact gcaccgacat     1200

aaaaaccaga catctaaagg tggtgctagg ggaccaggac ctgaagaaag aagaatttca     1260

tgagcagagc tttagggtgg agaagatatt caagtacagc cactacaatg aaagagatga     1320

gattccccac aatgatattg cattgctcaa gttaaagcca gtggatggtc actgtgctct     1380

agaatccaaa tacgtgaaga ctgtgtgctt gcctgatggg tcctttccct ctgggagtga     1440

gtgccacatc tctggctggg gtgttacaga aacaggaaaa gggtcccgcc agctcctgga     1500

tgccaaagtc aagctgattg ccaacacttt gtgcaactcc cgccaactct atgaccacat     1560

gattgatgac agtatgatct gtgcaggaaa tcttcagaaa cctgggcaag acacctgcca     1620

gggtgactct ggaggccccc tgacctgtga gaaggacggc acctactacg tctatgggat     1680

agtgagctgg ggcctggagt gtgggaagag gccaggggtc tacacccaag ttaccaaatt     1740

cctgaattgg atcaaagcca ccatcaaaag tgaaagtggc ttctaaggta ctgtcttctg     1800

gacctcagag cccactctcc ttggcaccct gacaccggga ggcctcatgg ccaacaatgg     1860

acacctccag agcctccagg ggaccacaca gtagactatc cctactctaa gcagagacaa     1920

ctgccaccca gcctgggcct tcccagacca gcatttgcac aatatcacca ggcttcttct     1980

gcctcccttg gtaacccaag gaatgatgga atcaacacaa catagtatgt ttgctttcct     2040

tacccaattg taccttctag aaaatcagtg ttcacagaga ctgcctccac cacaggcatc     2100

ctgcaaatgc agactccaga atccccagca tcagcgggaa ccaccatcac atctttattc     2160

ctcagcccag acactcgagg cactcaacag aatcagccat ccacgtctag gtatcagaga     2220

ggaccacaaa tacaacattc tccatctgct ttcagagtta ttattttaat aaaggaagat     2280

ctgggatggg ctggtgggcc attccagctt gccgaaatca aagccatctg aagcctgtct     2340

ctggtgaaca aacttcctct ctggcctctc aggaatcagg gtggacatgg ctcacaacag     2400

cagggccttc ttctttttga cgtgcagaat ctcagtggca tctgggttca cctccccact     2460

ctgatgatct ccagcctcca ctgcttctgc cccccgctgc tgaaatcaaa cataccccaa     2520

gttaaaatga agctccccca cccccactcc cggccccggt tcccacagga cacgctaaga     2580

agcacaggga gcatttaaca ggctcaccct ccctttcctt ttcccctctt ctaccctccc     2640

caagaaaaag ggccttcaag gcaggaatga gaaagcaaag ccaatctctc atttagacct     2700

ggcttctttc ttctgaacaa agtagggttc aaaatgcaga ctgtcatatc cagcgagtcc     2760

ctgacccttt ctgcgaatgt aacgagcaag cagtcagcac agcctgggct gccctggccc     2820

gggattgatg tagccccggt aggtttgcct ctgcagaact aatggctgtg acttcagaga     2880

aagccctgca ggaagtttaa cctgcgtgtc atctgcctgg tcatctcaga cccatgaaat     2940

taggcgcctt gtttgagctg cgtttcacac ttctttagag ctagctgacc tttggccaaa     3000

aataaacttt gaaaagaaa                                                  3019


<210>  10
<211>  517
<212>  PRT
<213>  Mus musculus

<400>  10

Met Leu Val Phe Arg Val Leu Leu Leu Ile Ala Leu Val Gly Lys Ser 
1               5                   10                  15      


Val Ile Gly Leu Ser Leu Met Ser Phe Ile Ala Pro Pro Asp Pro Asp 
            20                  25                  30          


Pro Cys Gln Ser Asn Pro Cys Glu His Gly Gly Asp Cys Ile Ile Arg 
        35                  40                  45              


Gly Asp Thr Phe Ser Cys Ser Cys Pro Ala Pro Phe Ser Gly Ser Arg 
    50                  55                  60                  


Cys Gln Thr Ala Gln Asn Lys Cys Lys Asp Asn Pro Cys Val His Gly 
65                  70                  75                  80  


Asp Cys Leu Ile Thr Gln Lys His Pro Tyr Tyr Arg Cys Ala Cys Lys 
                85                  90                  95      


Tyr Pro Tyr Thr Gly Pro Asp Cys Ser Lys Val Leu Pro Ala Cys Arg 
            100                 105                 110         


Pro Asn Pro Cys Gln Asn Gly Gly Val Cys Ser Arg His Arg Arg Arg 
        115                 120                 125             


Ser Arg Phe Thr Cys Ala Cys Pro Asp Gln Tyr Lys Gly Lys Phe Cys 
    130                 135                 140                 


Glu Ile Gly Pro Asp Asp Cys Tyr Val Gly Asp Gly Tyr Ser Tyr Arg 
145                 150                 155                 160 


Gly Lys Val Ser Lys Thr Val Asn Gln Asn Pro Cys Leu Tyr Trp Asn 
                165                 170                 175     


Ser His Leu Leu Leu Gln Glu Thr Tyr Asn Met Phe Met Glu Asp Ala 
            180                 185                 190         


Glu Thr His Gly Ile Ala Glu His Asn Phe Cys Arg Asn Pro Asp Gly 
        195                 200                 205             


Asp His Lys Pro Trp Cys Phe Val Lys Val Asn Ser Glu Lys Val Lys 
    210                 215                 220                 


Trp Glu Tyr Cys Asp Val Thr Val Cys Pro Val Pro Asp Thr Pro Asn 
225                 230                 235                 240 


Pro Val Glu Ser Leu Leu Glu Pro Val Met Glu Leu Pro Gly Phe Glu 
                245                 250                 255     


Ser Cys Gly Lys Thr Glu Val Ala Glu His Ala Val Lys Arg Ile Tyr 
            260                 265                 270         


Gly Gly Phe Lys Ser Thr Ala Gly Lys His Pro Trp Gln Val Ser Leu 
        275                 280                 285             


Gln Thr Ser Leu Pro Leu Thr Thr Ser Met Pro Gln Gly His Phe Cys 
    290                 295                 300                 


Gly Gly Ala Leu Ile His Pro Cys Trp Val Leu Thr Ala Ala His Cys 
305                 310                 315                 320 


Thr Asp Ile Asn Thr Lys His Leu Lys Val Val Leu Gly Asp Gln Asp 
                325                 330                 335     


Leu Lys Lys Thr Glu Ser His Glu Gln Thr Phe Arg Val Glu Lys Ile 
            340                 345                 350         


Leu Lys Tyr Ser Gln Tyr Asn Glu Arg Asp Glu Ile Pro His Asn Asp 
        355                 360                 365             


Ile Ala Leu Leu Lys Leu Lys Pro Val Gly Gly His Cys Ala Leu Glu 
    370                 375                 380                 


Ser Arg Tyr Val Lys Thr Val Cys Leu Pro Ser Asp Pro Phe Pro Ser 
385                 390                 395                 400 


Gly Thr Glu Cys His Ile Ser Gly Trp Gly Val Thr Glu Thr Gly Glu 
                405                 410                 415     


Gly Ser Arg Gln Leu Leu Asp Ala Lys Val Lys Leu Ile Ala Asn Pro 
            420                 425                 430         


Leu Cys Asn Ser Arg Gln Leu Tyr Asp His Thr Ile Asp Asp Ser Met 
        435                 440                 445             


Ile Cys Ala Gly Asn Leu Gln Lys Pro Gly Ser Asp Thr Cys Gln Gly 
    450                 455                 460                 


Asp Ser Gly Gly Pro Leu Thr Cys Glu Lys Asp Gly Thr Tyr Tyr Val 
465                 470                 475                 480 


Tyr Gly Ile Val Ser Trp Gly Gln Glu Cys Gly Lys Lys Pro Gly Val 
                485                 490                 495     


Tyr Thr Gln Val Thr Lys Phe Leu Asn Trp Ile Lys Thr Thr Met His 
            500                 505                 510         


Arg Glu Ala Gly Leu 
        515         


<210>  11
<211>  2119
<212>  DNA
<213>  Mus musculus

<400>  11
agagaaactg cagagggaga gaacagagag gccttcaact acacagatat ttgtcaggat       60

gttggtgttc cgtgtcctgc tgctaatcgc cctggtgggg aagtcagtca ttgggctctc      120

actgatgtcc ttcattgcgc ccccagaccc agatccatgc cagtccaacc cctgtgaaca      180

cggcggggac tgtatcatca gaggggatac cttcagttgc agctgcccag cccccttctc      240

ggggagccgg tgccagactg cacaaaacaa gtgcaaggac aacccatgtg tccatggtga      300

ttgcctcatt acccagaagc acccctacta ccgctgtgcc tgcaaatacc cttacacggg      360

accagactgc tccaaagtgc ttccggcatg caggccaaac ccctgccaga atggcggagt      420

ctgttcccga cacagacgga gatccaggtt tacctgtgcc tgtccagacc agtataaggg      480

gaaattctgt gaaataggtc cggacgactg ttatgtcggt gatggctact cttaccgagg      540

caaagtgagt aagacagtca accagaaccc atgcctttac tggaactccc acctcctctt      600

gcaggagact tataacatgt ttatggagga tgcagagacc cacgggatcg cagagcacaa      660

cttctgcaga aacccagatg gagaccacaa accctggtgt ttcgtcaagg tgaacagtga      720

gaaggtgaaa tgggaatact gtgatgtcac agtctgtcca gtgcctgaca cccctaaccc      780

agtggaaagc cttctggagc ctgtgatgga gctgccaggg ttcgagtcct gcgggaagac      840

ggaggtagct gaacacgcag tcaagcgtat ctacgggggc tttaagagca cagcaggcaa      900

gcacccgtgg caggtgtccc tgcagacctc actgccgttg accacctcca tgccccaagg      960

ccacttctgt gggggcgccc tgatccaccc ctgctgggtg ctcactgcag cccactgtac     1020

cgacataaac accaagcatc taaaagttgt actaggggat caggacctga agaagacaga     1080

atcccatgaa cagaccttca gggtggaaaa aatactgaag tacagtcagt ataatgaaag     1140

agatgagatt ccccacaatg acattgcttt gctcaagtta aagccagtgg gtggtcactg     1200

tgctctggaa tccagatatg tgaagactgt atgtttgccc agcgacccct ttccctctgg     1260

aactgagtgc cacatctctg gctggggtgt tacagaaaca ggggaagggt cccgccagct     1320

cctggatgct aaagtcaagc taatcgctaa ccctttgtgc aactcccgac aactctatga     1380

ccacaccatc gatgacagta tgatttgtgc ggggaacctt cagaagcccg gatcagacac     1440

ctgccagggt gactcggggg gccctctaac ctgtgagaag gatggaactt actacgtcta     1500

cgggattgta agctggggcc aggaatgtgg gaagaagcca ggagtctaca ctcaagtcac     1560

caagttcctg aattggataa agaccaccat gcacagggag gctggcctct gaggtgctgt     1620

ctgcagagcc ttgaagcccc tcgtctttag caccaaacaa gaggggcttc ctgcgtagcc     1680

agggatgtcc tgggtccatg ctctagacag aggcattgtt gcccagcctg ggcctttcca     1740

gactggcact atatcatttc atgaggcctt ttctctctgg gaaccaacaa gaaatacatt     1800

atctttgccc ccgttctgac aagtgtacct tctagataac cagaattcag agacgttctc     1860

caccatggag actgcgaatc tgagatccct gcttgccccg caccaggaga tgtttccttg     1920

actctttatc ttttgtccat accatcaggg tcctccacag aaccagccat tctcatgcag     1980

ccatcagaga gaagccccca aaaccacaag ctctttgttt gctttcagag ttgttatttt     2040

aataaaggca gatgtgggca cggggaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2100

aaaaaaaaaa aaaaaaaaa                                                  2119


<210>  12
<211>  560
<212>  PRT
<213>  Pan troglodytes

<400>  12

Met Phe Ala Arg Met Ser Asp Leu His Val Leu Leu Leu Met Ala Leu 
1               5                   10                  15      


Val Gly Lys Thr Ala Tyr Gly Phe Ser Leu Met Ser Leu Leu Glu Ser 
            20                  25                  30          


Leu Asp Pro Asp Trp Thr Pro Asp Gln Tyr Asp Tyr Ser Tyr Glu Asp 
        35                  40                  45              


Tyr Asn Glu Glu Glu Asn Thr Ser Ser Thr Leu Thr His Ala Glu Asn 
    50                  55                  60                  


Pro Asp Trp Tyr Tyr Thr Asp Asp Gln Thr Asp Pro Cys Gln Pro Asn 
65                  70                  75                  80  


Pro Cys Glu His Gly Gly Asp Cys Leu Val His Gly Ser Thr Phe Thr 
                85                  90                  95      


Cys Ser Cys Leu Ala Pro Phe Ser Gly Asn Lys Cys Gln Lys Val Gln 
            100                 105                 110         


Asn Thr Cys Lys Asp Asn Pro Cys Gly Arg Gly Gln Cys Leu Ile Thr 
        115                 120                 125             


Gln Ser Pro Pro His Tyr Arg Cys Val Cys Lys His Pro Tyr Thr Gly 
    130                 135                 140                 


Pro Ser Cys Ser Gln Val Val Pro Val Cys Arg Pro Asn Pro Cys Gln 
145                 150                 155                 160 


Asn Gly Ala Thr Cys Ser Arg His Lys Arg Arg Ser Lys Phe Thr Cys 
                165                 170                 175     


Ala Cys Pro Asp Gln Phe Lys Gly Lys Phe Cys Glu Ile Gly Ser Asp 
            180                 185                 190         


Asp Cys Tyr Val Gly Asp Gly Tyr Ser Tyr Arg Gly Lys Met Asn Arg 
        195                 200                 205             


Thr Val Asn Gln His Ala Cys Leu Tyr Trp Asn Ser His Leu Leu Leu 
    210                 215                 220                 


Gln Glu Asn Tyr Asn Met Phe Met Glu Asp Ala Glu Thr His Gly Ile 
225                 230                 235                 240 


Gly Glu His Asn Phe Cys Arg Asn Pro Asp Ala Asp Glu Lys Pro Trp 
                245                 250                 255     


Cys Phe Ile Lys Val Thr Asn Asp Lys Val Lys Trp Glu Tyr Cys Asp 
            260                 265                 270         


Val Ser Ala Cys Ser Ala Gln Asp Val Ala Tyr Pro Glu Glu Ser Pro 
        275                 280                 285             


Thr Glu Pro Ser Thr Lys Leu Pro Gly Phe Asp Ser Cys Gly Lys Thr 
    290                 295                 300                 


Glu Ile Ala Glu Arg Lys Ile Lys Arg Ile Tyr Gly Gly Phe Lys Ser 
305                 310                 315                 320 


Thr Ala Gly Lys His Pro Trp Gln Ala Ser Leu Gln Ser Ser Leu Pro 
                325                 330                 335     


Leu Thr Val Ser Met Pro Gln Gly His Phe Cys Gly Gly Ala Leu Ile 
            340                 345                 350         


His Pro Cys Trp Val Leu Thr Ala Ala His Cys Thr Asp Ile Lys Thr 
        355                 360                 365             


Arg His Leu Lys Val Val Leu Gly Asp Gln Asp Leu Lys Lys Glu Glu 
    370                 375                 380                 


Phe His Glu Gln Ser Phe Arg Val Glu Lys Ile Phe Lys Tyr Ser His 
385                 390                 395                 400 


Tyr Asn Glu Arg Asp Glu Ile Pro His Asn Asp Ile Ala Leu Leu Lys 
                405                 410                 415     


Leu Lys Pro Val Asp Gly His Cys Ala Leu Glu Ser Lys Tyr Val Lys 
            420                 425                 430         


Thr Val Cys Leu Pro Asp Gly Ser Phe Pro Ser Gly Ser Glu Cys His 
        435                 440                 445             


Ile Ser Gly Trp Gly Val Thr Glu Ala Gly Lys Gly Ser Arg Gln Leu 
    450                 455                 460                 


Leu Asp Ala Lys Val Lys Leu Ile Ala Asn Thr Leu Cys Asn Ser Arg 
465                 470                 475                 480 


Gln Leu Tyr Asp His Met Ile Asp Asp Ser Met Ile Cys Ala Gly Asn 
                485                 490                 495     


Leu Gln Lys Pro Gly Gln Asp Thr Cys Gln Gly Asp Ser Gly Gly Pro 
            500                 505                 510         


Leu Thr Cys Glu Lys Asp Gly Thr Tyr Tyr Val Tyr Gly Ile Val Ser 
        515                 520                 525             


Trp Gly Leu Glu Cys Gly Lys Arg Pro Gly Val Tyr Thr Gln Val Thr 
    530                 535                 540                 


Lys Phe Leu Asn Trp Ile Lys Ala Thr Ile Lys Ser Glu Ser Gly Phe 
545                 550                 555                 560 


<210>  13
<211>  522
<212>  PRT
<213>  Canis lupus familiaris

<400>  13

Asp Trp Thr Pro Asp Tyr Tyr Glu Asp Ser Tyr Glu Tyr His Asn Gln 
1               5                   10                  15      


Glu Glu Asp Val Asn Arg Thr Ala Ala Tyr Pro Glu Asn Pro Asp Trp 
            20                  25                  30          


Tyr Tyr Thr Glu Asp Asp Pro Cys Gln Ser Asn Pro Cys Glu His Gly 
        35                  40                  45              


Gly Asp Cys Leu Val Asn Gly Glu Asn Phe Thr Cys Ser Cys Pro Val 
    50                  55                  60                  


Pro Phe Ser Gly Asn Arg Cys Gln Asn Val Gln Asn Lys Cys Lys Glu 
65                  70                  75                  80  


Asn Pro Cys Asp Arg Gly Glu Cys Leu Ile Thr Gln Ser Pro Pro Tyr 
                85                  90                  95      


Tyr His Cys Ala Cys Arg His Pro Tyr Lys Gly Pro Asp Cys Ser Arg 
            100                 105                 110         


Ala Val Pro Val Cys Arg Pro Asn Pro Cys Gln Asn Gly Gly Thr Cys 
        115                 120                 125             


Ser Arg Gln Arg Arg Arg Ser Lys Phe Thr Cys Thr Cys Pro Asp Gln 
    130                 135                 140                 


Phe Lys Gly Lys Phe Cys Glu Ile Gly Pro Asp Asp Cys Tyr Val Gly 
145                 150                 155                 160 


Asp Gly Tyr Ser Tyr Arg Gly Lys Val Ser Lys Thr Val Asn Gln His 
                165                 170                 175     


Ser Cys Leu Tyr Trp Asn Ser His Leu Leu Leu His Glu Asn Tyr Asn 
            180                 185                 190         


Ile Phe Met Glu Asp Ala Glu Ala His Gly Ile Gly Glu His Asn Phe 
        195                 200                 205             


Cys Arg Asn Pro Asp Gly Asp Lys Lys Pro Trp Cys Phe Ile Lys Ala 
    210                 215                 220                 


Asn Asn Ala Lys Leu Lys Trp Glu Tyr Cys Asp Val Ser Ala Cys Ser 
225                 230                 235                 240 


Ala Leu Asp Ile Ala Asp Pro Glu Gly Ser Leu Thr Glu Pro Leu Thr 
                245                 250                 255     


Lys Leu Pro Gly Phe Asp Ser Cys Gly Arg Thr Glu Met Thr Lys Lys 
            260                 265                 270         


Val Lys Arg Ile Tyr Gly Gly Phe Lys Ser Thr Ala Gly Lys His Pro 
        275                 280                 285             


Trp Gln Ala Ser Leu Gln Thr Ser Leu Pro Leu Thr Val Ser Met Pro 
    290                 295                 300                 


Gln Gly His Phe Cys Gly Gly Ala Leu Ile His Pro Cys Trp Val Leu 
305                 310                 315                 320 


Thr Ala Ala His Cys Thr Asn Ile Lys Ala Arg His Leu Thr Val Val 
                325                 330                 335     


Leu Gly Asp Gln Asp Leu Lys Lys Thr Glu Phe His Glu Gln Arg Phe 
            340                 345                 350         


Gly Val Glu Lys Ile Phe Lys Tyr Ser Leu Tyr Asn Glu Arg Glu Glu 
        355                 360                 365             


Ile Pro His Asn Asp Ile Ala Leu Leu Lys Leu Lys Pro Val Asp Gly 
    370                 375                 380                 


His Cys Ala Leu Glu Ser Lys Tyr Val Lys Thr Val Cys Leu Pro Asn 
385                 390                 395                 400 


Ser Ala Phe Pro Ser Gly Thr Glu Cys His Ile Ser Gly Trp Gly Val 
                405                 410                 415     


Thr Glu Thr Gly Glu Gly Ser Arg Gln Leu Leu Asp Ala Lys Val Arg 
            420                 425                 430         


Leu Ile Ala Asn Thr Leu Cys Asn Ser Arg Gln Leu Tyr Asp His Met 
        435                 440                 445             


Ile Gly Asp Ser Met Ile Cys Ala Gly Asn Leu Gln Lys Pro Gly Gln 
    450                 455                 460                 


Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Thr Cys Glu Lys Asn 
465                 470                 475                 480 


Gly Thr Tyr Tyr Val Tyr Gly Ile Val Ser Trp Gly Leu Glu Cys Gly 
                485                 490                 495     


Lys Lys Pro Gly Val Tyr Thr Gln Val Ala Lys Phe Leu Asn Trp Ile 
            500                 505                 510         


Lys Ala Thr Ile Gln Lys Gly Ser Ser Phe 
        515                 520         


<210>  14
<211>  558
<212>  PRT
<213>  Rattus norvegicus

<400>  14

Met Ser Val Val Met Leu Val Phe Arg Val Leu Leu Leu Ile Ala Leu 
1               5                   10                  15      


Val Gly Asn Ser Ala Ile Gly Leu Ser Leu Met Pro Phe Ile Ala Pro 
            20                  25                  30          


Pro Asp Pro Asp Trp Thr Pro Asp Asp Tyr Tyr Tyr Ser Tyr Glu Gln 
        35                  40                  45              


Ser Ser Pro Asp Lys Asp Ala Ser Val Thr Gln Thr Ser Pro Glu Asn 
    50                  55                  60                  


Pro Asp Trp Tyr Tyr Glu Asp Asp Asp Pro Cys Gln Ser Asn Pro Cys 
65                  70                  75                  80  


Glu His Gly Gly Asp Cys Ile Ile Arg Gly Asn Thr Phe Ser Cys Ser 
                85                  90                  95      


Cys Pro Ala Pro Phe Ser Gly Ser Arg Cys Gln Thr Val Gln Asn Lys 
            100                 105                 110         


Cys Lys Asp Asn Pro Cys Val Gln Gly Asp Cys Leu Ile Thr Gln Thr 
        115                 120                 125             


Pro Pro Tyr Tyr Arg Cys Ala Cys Lys Tyr Pro Tyr Thr Gly Pro Asp 
    130                 135                 140                 


Cys Ser Lys Val Leu Pro Val Cys Arg Pro Asn Pro Cys Gln Asn Gly 
145                 150                 155                 160 


Gly Val Cys Ser Arg His Arg Arg Arg Ser Arg Phe Ser Cys Ala Cys 
                165                 170                 175     


Pro Asp Gln Tyr Lys Gly Arg Phe Cys Glu Ile Gly Pro Asp Asp Cys 
            180                 185                 190         


Tyr Val Gly Asp Gly Tyr Ser Tyr Arg Gly Lys Val Ser Arg Thr Val 
        195                 200                 205             


Asn Gln Asn Pro Cys Leu Tyr Trp Asn Ser His Leu Leu Leu Gln Glu 
    210                 215                 220                 


Asn Tyr Asn Met Phe Met Glu Asp Ala Glu Thr His Gly Ile Ala Asp 
225                 230                 235                 240 


His Asn Phe Cys Arg Asn Pro Asp Gly Asp His Lys Pro Trp Cys Phe 
                245                 250                 255     


Val Lys Val Asn Ser Glu Lys Val Lys Trp Glu Tyr Cys Asn Val Glu 
            260                 265                 270         


Val Cys Pro Glu Ser Asp Ala Ala Asn Pro Val Gly Ser Leu Gln Glu 
        275                 280                 285             


Pro Val Met Glu Leu Pro Gly Phe Asp Ser Cys Gly Lys Thr Glu Met 
    290                 295                 300                 


Thr Glu His Ala Val Lys Arg Ile Tyr Gly Gly Phe Lys Ser Thr Ala 
305                 310                 315                 320 


Gly Lys His Pro Trp Gln Val Ser Leu Gln Thr Ser Leu Pro Leu Thr 
                325                 330                 335     


Thr Ser Met Pro Gln Gly His Phe Cys Gly Gly Ser Leu Ile His Pro 
            340                 345                 350         


Cys Trp Val Leu Thr Ala Ala His Cys Thr Asp Met Ser Thr Lys His 
        355                 360                 365             


Leu Lys Val Val Leu Gly Asp Gln Asp Leu Lys Lys Thr Glu Ser His 
    370                 375                 380                 


Glu Gln Thr Phe Arg Val Glu Lys Ile Leu Lys Tyr Ser Gln Tyr Asn 
385                 390                 395                 400 


Glu Arg Asp Glu Ile Pro His Asn Asp Ile Ala Leu Leu Lys Leu Lys 
                405                 410                 415     


Pro Val Gly Gly His Cys Ala Leu Glu Ser Lys Tyr Val Lys Thr Val 
            420                 425                 430         


Cys Leu Pro Ser Asp Pro Phe Pro Ser Gly Thr Glu Cys His Ile Ser 
        435                 440                 445             


Gly Trp Gly Val Thr Glu Thr Gly Glu Gly Ser Arg Gln Leu Leu Asp 
    450                 455                 460                 


Ala Lys Val Lys Leu Ile Ala Asn Ala Leu Cys Asn Ser Arg Gln Leu 
465                 470                 475                 480 


Tyr Asp His Thr Ile Asp Asp Ser Met Ile Cys Ala Gly Asn Leu Gln 
                485                 490                 495     


Lys Pro Gly Ser Asp Thr Cys Gln Gly Asp Ser Gly Gly Pro Leu Thr 
            500                 505                 510         


Cys Glu Lys Asp Gly Thr Tyr Tyr Val Tyr Gly Ile Val Ser Trp Gly 
        515                 520                 525             


Gln Glu Cys Gly Lys Lys Pro Gly Val Tyr Thr Gln Val Thr Lys Phe 
    530                 535                 540                 


Leu Asn Trp Ile Lys Thr Thr Met His Lys Glu Ala Gly Leu 
545                 550                 555             


<210>  15
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Leu Pro Pro Pro Arg Pro Ala Ala Ala Leu Ala Leu Pro Val Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Val Leu Thr Pro Pro Pro Thr Gly Ala Arg Pro 
            20                  25                  30          


Ser Pro Gly Pro Asp Tyr Leu Arg Arg Gly Trp Met Arg Leu Leu Ala 
        35                  40                  45              


Glu Gly Glu Gly Cys Ala Pro Cys Arg Pro Glu Glu Cys Ala Ala Pro 
    50                  55                  60                  


Arg Gly Cys Leu Ala Gly Arg Val Arg Asp Ala Cys Gly Cys Cys Trp 
65                  70                  75                  80  


Glu Cys Ala Asn Leu Glu Gly Gln Leu Cys Asp Leu Asp Pro Ser Ala 
                85                  90                  95      


His Phe Tyr Gly His Cys Gly Glu Gln Leu Glu Cys Arg Leu Asp Thr 
            100                 105                 110         


Gly Gly Asp Leu Ser Arg Gly Glu Val Pro Glu Pro Leu Cys Ala Cys 
        115                 120                 125             


Arg Ser Gln Ser Pro Leu Cys Gly Ser Asp Gly His Thr Tyr Ser Gln 
    130                 135                 140                 


Ile Cys Arg Leu Gln Glu Ala Ala Arg Ala Arg Pro Asp Ala Asn Leu 
145                 150                 155                 160 


Thr Val Ala His Pro Gly Pro Cys Glu Ser Gly Pro Gln Ile Val Ser 
                165                 170                 175     


His Pro Tyr Asp Thr Trp Asn Val Thr Gly Gln Asp Val Ile Phe Gly 
            180                 185                 190         


Cys Glu Val Phe Ala Tyr Pro Met Ala Ser Ile Glu Trp Arg Lys Asp 
        195                 200                 205             


Gly Leu Asp Ile Gln Leu Pro Gly Asp Asp Pro His Ile Ser Val Gln 
    210                 215                 220                 


Phe Arg Gly Gly Pro Gln Arg Phe Glu Val Thr Gly Trp Leu Gln Ile 
225                 230                 235                 240 


Gln Ala Val Arg Pro Ser Asp Glu Gly Thr Tyr Arg Cys Leu Gly Arg 
                245                 250                 255     


Asn Ala Leu Gly Gln Val Glu Ala Pro Ala Ser Leu Thr Val Leu Thr 
            260                 265                 270         


Pro Asp Gln Leu Asn Ser Thr Gly Ile Pro Gln Leu Arg Ser Leu Asn 
        275                 280                 285             


Leu Val Pro Glu Glu Glu Ala Glu Ser Glu Glu Asn Asp Asp Tyr Tyr 
    290                 295                 300                 


<210>  16
<211>  2514
<212>  DNA
<213>  Homo sapiens

<400>  16
aaagtgccac ggtggcggtg gtggcggccg cgaggccgag tgtctccggc cctgccagcc       60

tcgcaaccgt aacctgtaat cccgacccga gggacgcccg ccggggaggc gccagcccgc      120

ctctccctgc ggccgctggt cggctccgac ctcgaatcac ccggctcacc cgcgggtcgc      180

agcacctgcc ggatgtgggg aggaagaagg aggccagatg agggaaggcg gatgtaggcg      240

cccagtctgt ccgcgccttg gtggggcagc tgggtgggca agcctgcggt cgctcccggg      300

aaccagccct gggctgcggg gagacgaagg tggttggtcc tgccctccag gagcgccccg      360

acatcgacgt aaaatgactt ggcaccagag ctcctgccgc ctccccctta tgcagctgcc      420

ctcgccgacg ccagggactg taaaatcaga tgggacaggg cctagccgtt cagccaacac      480

tttgagcttc ccagccaaac tcctaccccc actccccgcc tccggtcctc acccccttcc      540

tctctcccag cctcggtgtc tggttacggc tcctctgctc gcattgtgac tttgggccag      600

gctgggggaa atgacccggg agggtcccat gcggctacat aaaattggca gccttagaac      660

tagtgggaag gcgggtgcgc gaagtcgagg ggcggagaga gggggccgga ggagctgctt      720

tctgaatcca agttcgtggg ctctctcaga agtcctcagg acggagcaga ggtggccggc      780

gggcccggct gactgcgcct ctgctttctt tccataacct tttctttcgg actcgaatca      840

cggctgctgc gaagggtcta gttccggaca ctagggtgcc cgaacgcgct gatgccccga      900

gtgctcgcag ggcttcccgc taaccatgct gccgccgccg cggcccgcag ctgccttggc      960

gctgcctgtg ctcctgctac tgctggtggt gctgacgccg cccccgaccg gcgcaaggcc     1020

atccccaggc ccagattacc tgcggcgcgg ctggatgcgg ctgctagcgg agggcgaggg     1080

ctgcgctccc tgccggccag aagagtgcgc cgcgccgcgg ggctgcctgg cgggcagggt     1140

gcgcgacgcg tgcggctgct gctgggaatg cgccaacctc gagggccagc tctgcgacct     1200

ggaccccagt gctcacttct acgggcactg cggcgagcag cttgagtgcc ggctggacac     1260

aggcggcgac ctgagccgcg gagaggtgcc ggaacctctg tgtgcctgtc gttcgcagag     1320

tccgctctgc gggtccgacg gtcacaccta ctcccagatc tgccgcctgc aggaggcggc     1380

ccgcgctcgg cccgatgcca acctcactgt ggcacacccg gggccctgcg aatcggggcc     1440

ccagatcgtg tcacatccat atgacacttg gaatgtgaca gggcaggatg tgatctttgg     1500

ctgtgaagtg tttgcctacc ccatggcctc catcgagtgg aggaaggatg gcttggacat     1560

ccagctgcca ggggatgacc cccacatctc tgtgcagttt aggggtggac cccagaggtt     1620

tgaggtgact ggctggctgc agatccaggc tgtgcgtccc agtgatgagg gcacttaccg     1680

ctgccttggc cgcaatgccc tgggtcaagt ggaggcccct gctagcttga cagtgctcac     1740

acctgaccag ctgaactcta caggcatccc ccagctgcga tcactaaacc tggttcctga     1800

ggaggaggct gagagtgaag agaatgacga ttactactag gtccagagct ctggcccatg     1860

ggggtgggtg agcggctata gtgttcatcc ctgctcttga aaagacctgg aaaggggagc     1920

agggtccctt catcgactgc tttcatgctg tcagtaggga tgatcatggg aggcctattt     1980

gactccaagg tagcagtgtg gtaggataga gacaaaagct ggaggagggt agggagagaa     2040

gctgagacca ggaccggtgg ggtacaaagg ggcccatgca ggagatgccc tggccagtag     2100

gacctccaac aggttgtttc ccaggctggg gtgggggcct gagcagacac agaggtgcag     2160

gcaccaggat tctccacttc ttccagccct gctgggccac agttctaact gcccttcctc     2220

ccaggccctg gttcttgcta tttcctggtc cccaacgttt atctagcttg tttgcccttt     2280

ccccaaactc atcttccaga acttttccct ctctcctaag ccccagttgc acctactaac     2340

tgcagtccct tttgctgtct gccgtctttt gtacaagaga gagaacagcg gagcatgact     2400

tagttcagtg cagagagata ggtgaggcca gctcgagatc ttataccact ctgtattgga     2460

caaaggctag cacagggcta ggcaccaata aagatttcta atgatgcaca gaca           2514


<210>  17
<211>  313
<212>  PRT
<213>  Mus musculus

<400>  17

Met Pro Arg Val Phe Thr Gly Leu Pro Ala Asn Tyr Ala Ala Pro Thr 
1               5                   10                  15      


Leu Ala Leu Ser Leu Leu Leu Pro Leu Leu Leu Val Val Trp Thr Gln 
            20                  25                  30          


Leu Pro Val Ser Ala Arg Pro Ser Thr Gly Pro Asp Tyr Leu Arg Arg 
        35                  40                  45              


Gly Trp Leu Arg Leu Leu Ala Glu Gly Glu Gly Cys Ala Pro Cys Arg 
    50                  55                  60                  


Pro Glu Glu Cys Ala Ala Pro Arg Gly Cys Leu Ala Gly Arg Val Arg 
65                  70                  75                  80  


Asp Ala Cys Gly Cys Cys Trp Glu Cys Ala Asn Leu Glu Gly Gln Leu 
                85                  90                  95      


Cys Asp Leu Asp Pro Ser Ala Asn Phe Tyr Gly Arg Cys Gly Glu Gln 
            100                 105                 110         


Leu Glu Cys Arg Leu Asp Ala Gly Gly Asp Leu Ser Arg Gly Glu Val 
        115                 120                 125             


Pro Glu Pro Leu Cys Val Cys Arg Ser Gln Arg Pro Leu Cys Gly Ser 
    130                 135                 140                 


Asp Gly Arg Thr Tyr Ala Gln Ile Cys Arg Leu Gln Glu Ala Ala Arg 
145                 150                 155                 160 


Ala Arg Leu Asp Ala Asn Leu Thr Val Val His Pro Gly Pro Cys Glu 
                165                 170                 175     


Ser Glu Pro Gln Ile Leu Ser Gln Pro His Asn Ile Trp Asn Val Thr 
            180                 185                 190         


Gly Gln Asp Val Ile Phe Gly Cys Glu Val Phe Ala Tyr Pro Met Ala 
        195                 200                 205             


Ser Ile Glu Trp Arg Lys Asp Gly Leu Asp Ile Gln Leu Pro Gly Asp 
    210                 215                 220                 


Asp Pro His Ile Ser Val Gln Phe Arg Gly Gly Pro Gln Lys Phe Glu 
225                 230                 235                 240 


Val Thr Gly Trp Leu Gln Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly 
                245                 250                 255     


Thr Tyr Arg Cys Leu Ala Arg Asn Ala Leu Gly Gln Ala Glu Ala Ser 
            260                 265                 270         


Ala Thr Leu Thr Val Leu Thr Pro Glu Gln Leu Asn Ala Thr Gly Phe 
        275                 280                 285             


Ser Gln Leu Gln Ser Arg Ser Leu Phe Pro Glu Glu Glu Glu Glu Ala 
    290                 295                 300                 


Glu Ser Glu Glu Leu Gly Asp Tyr Tyr 
305                 310             


<210>  18
<211>  1383
<212>  DNA
<213>  Mus musculus

<400>  18
tggccgtgca tgcgactctt cgttccctac cgtttttttt tttttttttt ttttaggttg       60

gaaatcccag ctgttaaggg cctagtccaa ggcactaggg tgccacctac gcgccgatgc      120

cccgagtgtt cacagggctt ccagctaact atgctgcacc taccttggcg ctgtccttgc      180

tactaccatt attgctggtg gtgtggaccc agctacccgt tagcgcgagg ccgtccacag      240

gccccgatta cctgcggcga ggctggctgc ggctgctagc cgagggcgag ggttgtgctc      300

cctgccggcc agaagagtgc gctgcgccgc ggggatgcct agcaggccgg gtgcgggatg      360

cgtgcggctg ctgctgggaa tgcgcaaacc tggagggcca gctctgcgat ctggacccca      420

gcgctaactt ctacgggcgc tgcggcgagc agctcgagtg caggctggac gcgggcggtg      480

acctgagtcg aggagaggtg ccggagccgc tgtgtgtctg ccgctcgcag cgcccgctct      540

gtggttcgga cggccgaacc tacgcgcaga tctgtcgcct gcaggaggcc gcccgcgctc      600

ggctggacgc taacctcact gtggtgcatc cggggccctg cgaatcggag ccccagatcc      660

tgtcgcagcc tcacaatatt tggaatgtga ccggacagga tgtgatcttt ggctgtgagg      720

tgtttgccta ccccatggcc tcgattgagt ggaggaaaga tggcttggac atccagctgc      780

cgggggatga ccctcatatc tctgtgcagt ttaggggtgg acctcagaag tttgaggtga      840

ctggctggct acagattcaa gctttgcgcc ctagtgatga gggcacctac cgttgccttg      900

cccggaatgc tctgggccaa gcggaagctt ctgcaaccct cacagtgctc acaccagagc      960

agctgaacgc cacgggattc tcccagctgc aatcacggag tttgtttcct gaggaggagg     1020

aggaggcaga aagtgaagag ttgggcgatt actactaggt ccagatctct gctttgcagg     1080

tgtgggcatg tggacagagc cctgcatcct tgctgtctag aaagcccgga gaagactgga     1140

aaaggcgagc agggtcctta catggattgt ttaatgctca gtgtagcctc agctcatctt     1200

tcctcaaaac tcatctttca gaagcgtccg cggtagagat gagcgcagcg gaactgattt     1260

agttcagtac agggagaggg gtggggtagc tccgtgtctt atacactcta ggggacaaaa     1320

cccacctagc atacgactag acacagtggg caccaataaa aaaatatata aacaaaccga     1380

aaa                                                                   1383


<210>  19
<211>  304
<212>  PRT
<213>  Rattus norvegicus

<400>  19

Met Pro Arg Val Phe Thr Gly Leu Pro Ala Asn His Ala Ala Pro Ser 
1               5                   10                  15      


Leu Ala Leu Pro Leu Val Leu Leu Leu Leu Met Val Ser Ala Arg Pro 
            20                  25                  30          


Ser Thr Gly Pro Asp Tyr Leu Arg Arg Gly Trp Leu Arg Leu Leu Ala 
        35                  40                  45              


Glu Gly Glu Gly Cys Ala Pro Cys Arg Pro Glu Glu Cys Ala Ala Pro 
    50                  55                  60                  


Arg Gly Cys Leu Ala Gly Arg Val Arg Asp Ala Cys Gly Cys Cys Trp 
65                  70                  75                  80  


Glu Cys Ala Asn Leu Glu Gly Gln Leu Cys Asp Leu Asp Pro Ser Ala 
                85                  90                  95      


Asn Phe Tyr Gly Arg Cys Gly Glu Gln Leu Glu Cys Arg Leu Asp Ala 
            100                 105                 110         


Gly Gly Asp Leu Ser Arg Gly Glu Val Pro Glu Pro Leu Cys Val Cys 
        115                 120                 125             


Arg Ser Gln Arg Pro Leu Cys Gly Ser Asp Gly Arg Thr Tyr Ala Gln 
    130                 135                 140                 


Val Cys Arg Leu Gln Glu Val Ala Arg Ala Arg Pro Asp Ala Asn Leu 
145                 150                 155                 160 


Thr Val Val His Pro Gly Pro Cys Glu Ser Glu Pro Gln Ile Leu Ser 
                165                 170                 175     


Gln Pro His Asn Ile Trp Asn Val Thr Gly Gln Asp Val Ile Phe Gly 
            180                 185                 190         


Cys Glu Val Phe Ala Tyr Pro Met Ala Ser Ile Glu Trp Arg Lys Asp 
        195                 200                 205             


Gly Leu Asp Ile Gln Leu Pro Gly Asp Asp Pro His Ile Ser Val Gln 
    210                 215                 220                 


Phe Arg Gly Gly Pro Gln Lys Phe Glu Val Thr Gly Trp Leu Gln Ile 
225                 230                 235                 240 


Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr Arg Cys Leu Ala Arg 
                245                 250                 255     


Asn Ala Leu Gly Gln Ala Glu Ala Ser Ala Thr Leu Thr Val Leu Thr 
            260                 265                 270         


Pro Asp Gln Leu Asn Ala Thr Gly Phe Ser Gln Leu Gln Ser Gln Gly 
        275                 280                 285             


Leu Ile Pro Glu Glu Glu Ala Glu Asp Glu Glu Leu Glu Asp Tyr Tyr 
    290                 295                 300                 


<210>  20
<211>  303
<212>  PRT
<213>  Pan troglodytes

<400>  20

Met Pro Pro Pro Pro Pro Ala Ala Ala Leu Ala Leu Pro Val Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Val Leu Thr Pro Pro Pro Thr Gly Ala Arg Pro Ser 
            20                  25                  30          


Pro Gly Pro Asp Tyr Leu Arg Arg Gly Trp Leu Arg Leu Leu Ala Glu 
        35                  40                  45              


Gly Glu Gly Cys Ala Pro Cys Arg Pro Glu Glu Cys Ala Ala Pro Arg 
    50                  55                  60                  


Gly Cys Leu Ala Gly Trp Val Arg Asp Ala Cys Gly Cys Cys Trp Glu 
65                  70                  75                  80  


Cys Ala Asn Leu Glu Gly Gln Leu Cys Asp Leu Asp Pro Ser Ala His 
                85                  90                  95      


Phe Tyr Gly His Cys Gly Glu Gln Leu Glu Cys Arg Leu Asp Thr Gly 
            100                 105                 110         


Asp Asp Leu Ser Arg Gly Glu Val Pro Glu Pro Leu Cys Ala Cys Arg 
        115                 120                 125             


Ser Gln Ser Pro Leu Cys Gly Ser Asp Gly His Thr Tyr Ser Gln Ile 
    130                 135                 140                 


Cys Arg Leu Gln Glu Ala Ala Arg Ala Arg Pro Asp Ala Asn Leu Thr 
145                 150                 155                 160 


Val Ala His Pro Gly Pro Cys Glu Ser Gly Pro Gln Ile Val Ser His 
                165                 170                 175     


Pro Tyr Asp Thr Trp Asn Val Thr Gly Gln Asp Val Ile Phe Gly Cys 
            180                 185                 190         


Glu Val Phe Ala Tyr Pro Met Ala Ser Ile Glu Trp Arg Lys Asp Gly 
        195                 200                 205             


Leu Asp Ile Gln Leu Pro Gly Asp Asp Pro His Ile Ser Val Gln Phe 
    210                 215                 220                 


Arg Gly Gly Pro Gln Arg Phe Glu Val Thr Gly Trp Leu Gln Ile Gln 
225                 230                 235                 240 


Ala Val Arg Pro Ser Asp Glu Gly Thr Tyr Arg Cys Leu Ala Arg Asn 
                245                 250                 255     


Ala Leu Gly Gln Val Glu Ala Pro Ala Ser Leu Thr Val Leu Thr Pro 
            260                 265                 270         


Asp Gln Leu Asn Ala Thr Gly Ile Pro Gln Leu Arg Ser Leu Asn Leu 
        275                 280                 285             


Val Pro Glu Glu Glu Ala Glu Ser Glu Glu Asn Asp Asp Tyr Tyr 
    290                 295                 300             


<210>  21
<211>  247
<212>  PRT
<213>  Canis lupus familiaris

<400>  21

Leu Thr Met Pro Pro Pro Pro Ala Ala Ala Leu Ala Leu Pro Ser Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Arg Thr Pro Pro Pro Thr Gly Ala Arg Pro 
            20                  25                  30          


Ser Pro Gly Pro Asp Tyr Leu Arg Arg Gly Trp Leu Arg Leu Leu Ala 
        35                  40                  45              


Glu Gly Glu Gly Cys Ala Pro Cys Arg Pro Glu Asp Cys Ala Ala Pro 
    50                  55                  60                  


Arg Gly Cys Leu Ala Gly Arg Val Arg Asp Ala Cys Gly Cys Cys Trp 
65                  70                  75                  80  


Glu Cys Ala Asn Leu Glu Gly Gln Leu Cys Asp Leu Asp Pro Ser Ala 
                85                  90                  95      


His Phe Tyr Gly Arg Cys Gly Glu Gln Leu Glu Cys Arg Leu Asp Ala 
            100                 105                 110         


Gly Gly Asp Leu Ser Arg Gly Glu Val Pro Glu Pro Leu Cys Ala Cys 
        115                 120                 125             


Arg Ser Gln Arg Pro Leu Cys Gly Ser Asp Gly Arg Thr Tyr Ala Gln 
    130                 135                 140                 


Ile Cys Arg Leu Gln Glu Ala Ala Arg Ala Arg Pro Asp Ala Asn Leu 
145                 150                 155                 160 


Thr Val Ala His Pro Gly Pro Cys Glu Ser Glu Pro Gln Ile Val Leu 
                165                 170                 175     


His Pro Tyr Asp Ile Trp Arg Ser Ser Arg Leu Gln Ser Leu Gly Thr 
            180                 185                 190         


Lys Gly Thr Pro Thr Val Leu Leu Arg Met Gly Val Arg Gly Lys Ala 
        195                 200                 205             


Trp Gly Thr Pro Ala Pro Arg Phe Pro Pro Arg Pro Lys Gly Thr Thr 
    210                 215                 220                 


Ala Leu Ala Thr Pro Leu Ala Thr Leu Gly Ser Thr Gly Ser Gly Lys 
225                 230                 235                 240 


Arg Val Pro Ser Gly Gly Tyr 
                245         


<210>  22
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Val Asp Val Glu Phe Gly Val Ala Gly Trp Trp Glu Ala Ala 
1               5                   10                  15      


Ala Pro Leu Ser Pro Ser Ala Val Ala Ala Thr Phe Thr Glu Thr Trp 
            20                  25                  30          


Pro Gly Ser Glu Arg Ala Glu Pro Gly Arg Ile Gln His Pro Leu Trp 
        35                  40                  45              


Pro Gly Ser Ser Glu Gly Leu Gln Leu Leu Val Cys Phe Leu Leu Leu 
    50                  55                  60                  


Asn Ser Cys Pro Gly Gly Cys Ser Asp Thr Ser Ala His Asp Gly Gln 
65                  70                  75                  80  


Asp Gln Val Gly Val Gly Gln Leu Trp Pro Leu Gln Gly Phe Ala Thr 
                85                  90                  95      


Pro Val Phe Gln His Leu Gln Val Val Leu Gln Gln Ile Ile Pro Gln 
            100                 105                 110         


Gly Leu Phe Trp Lys Asp Asp Ile Thr Gln Asp Ala Met Ile Gln Lys 
        115                 120                 125             


Met Glu His Ala Ser Arg Leu His Pro Gln Glu Pro Cys Leu Lys Asp 
    130                 135                 140                 


Gly Lys Ala Leu Phe Pro Thr Lys Thr Thr Glu Ser Pro Leu Ala Lys 
145                 150                 155                 160 


Val Asn Arg Asp Gln Cys Phe Thr Ser Glu Val Val Ser Lys Ala Leu 
                165                 170                 175     


Lys Gln Glu Val Ala Asn Pro Val Lys Ile Thr Tyr Arg Cys Ser Tyr 
            180                 185                 190         


Gly Gly Leu Asp Met Met Gln Ala Pro Gly Pro Ser Lys Glu Glu Ile 
        195                 200                 205             


Ile Tyr Lys Ile Met Arg Leu Leu Trp Ala Thr Ser Tyr Cys Gly Pro 
    210                 215                 220                 


Gln Pro Cys Gly 
225             


<210>  23
<211>  795
<212>  DNA
<213>  Homo sapiens

<400>  23
atggcagtgg atgtggaatt cggagtcgcg ggctggtggg aagctgcagc cccgctcagc       60

ccctcggccg tggccgctac cttcactgag acttggccgg ggagtgagcg cgccgagcct      120

gggaggatac agcacccact gtggcctggg agctccgagg ggctccagct gcttgtctgc      180

ttcctgctgc tgaacagctg cccggggggc tgcagcgaca ctagtgccca cgatggtcag      240

gaccaagtag gagtggggca gctttggccc ctccaaggat ttgccacccc agtcttccag      300

catttacagg ttgtgctcca gcagattata ccccaaggtc tgttctggaa ggatgacatc      360

acccaggatg caatgatcca aaagatggag catgccagca gactgcatcc ccaagaacca      420

tgcctgaagg atgggaaggc acttttcccc actaaaacca ctgagagccc cctggccaag      480

gtgaacaggg atcagtgctt tacctccgaa gtggtttcta aggccctgaa acaagaggtg      540

gccaaccctg tcaagattac ctataggtgt tcatatgggg ggctggacat gatgcaggcg      600

ccgggaccct ctaaggaaga aattatctat aagatcatgc ggcttctctg ggccacttcc      660

tactgtgggc cgcaaccctg tggctgattg agacctcatg tgaagcctcc ctgccccagc      720

acccttccca ttgcccttca gaggagcagt tcttggatga cccagatttg aatcattaaa      780

gtagactctc atgca                                                       795


<210>  24
<211>  175
<212>  PRT
<213>  Mus musculus

<400>  24

Met Gln Ser Ser Leu Lys Pro Ala Gly Ser Gly His Leu Gln Leu Leu 
1               5                   10                  15      


Val Cys Phe Leu Leu Leu Tyr Ser Arg Pro Gly Ser Cys Ser Asp Ile 
            20                  25                  30          


Asn Ala His Asp Gly Gln Gly Gln Val Gly Ser Glu Gln Leu Trp Thr 
        35                  40                  45              


Phe Gln Gly Leu Ile Ala Ser Val Phe Gln Tyr Leu Gln Leu Ile Phe 
    50                  55                  60                  


His Gln Ile Val Pro Glu Gly Met Phe Trp Ala Asp Asp Ile Ala Tyr 
65                  70                  75                  80  


Glu Leu Met Thr Lys Lys Val Glu His Leu Ser Arg Leu His Pro Gln 
                85                  90                  95      


Tyr Pro Cys Arg Lys Asp Met Lys Ala Val Ser Pro Thr Ala Asn Ala 
            100                 105                 110         


Gly Val Arg Ser Lys Gln Glu Glu Lys Leu Gln Leu Leu Ser Pro Gln 
        115                 120                 125             


Lys Ser Pro Thr Val Lys Val Asn Arg Asp Arg Cys Phe Thr Thr Lys 
    130                 135                 140                 


Val Ile Pro Lys Ala Thr Lys Gln Glu Ala Thr His Pro Thr Lys Gly 
145                 150                 155                 160 


Phe Phe Gly Pro Phe Pro Thr Val Gly Leu Asn Leu Val Ala Asp 
                165                 170                 175 


<210>  25
<211>  710
<212>  DNA
<213>  Mus musculus

<400>  25
caggccccct ggctattgtt gctacttcca ctacgaccta gctcgaggaa ccgtgagttt       60

ggatccagcc aagatgcaga gttcgttaaa gcccgcgggc tccgggcatc ttcagctact      120

ggtctgcttc cttctgcttt acagtcgtcc aggcagctgc agcgacataa acgcccacga      180

tggtcagggc caagtgggat cggaacagct ctggacattc caaggactta ttgcttcagt      240

cttccagtac ttacaactta tattccacca gattgtaccc gaaggcatgt tctgggcaga      300

tgacatagcc tatgagttaa tgaccaaaaa ggtggagcac ctcagcagac tccaccccca      360

gtatccatgc aggaaggata tgaaggcagt ttcccccacg gcaaacgctg gggtgaggag      420

caagcaagag gagaaacttc aactcttatc tccccaaaag agtccaacag tcaaggtgaa      480

cagggaccga tgctttacca ccaaagtaat cccaaaggcc accaaacaag aggccaccca      540

tcctaccaag ggtttctttg ggccattccc cactgtgggc ctcaaccttg ttgctgactg      600

agatctcgtt gcataagatc cctttctccg ggaacctcct caatgccctc caatccaagg      660

ggcaattctt ggatgaccca aatatgaata attaaagttg attttcctgc                 710


<210>  26
<211>  175
<212>  PRT
<213>  Rattus norvegicus

<400>  26

Met Gln Ser Ser Leu Lys Pro Ala Gly Ser Gly Val Leu Gln Leu Leu 
1               5                   10                  15      


Val Cys Phe Leu Leu Leu Tyr Ser Arg Pro Ser Ser Cys Ser Asp Ile 
            20                  25                  30          


Asn Ala His Asp Gly Gln Gly Gln Val Gly Ser Glu Gln Leu Trp Thr 
        35                  40                  45              


Phe Gln Gly Leu Val Ala Ser Val Phe Gln Tyr Leu Gln Leu Leu Phe 
    50                  55                  60                  


His His Ile Val Pro Gln Gly Met Phe Trp Thr Asp Asp Ile Ala Tyr 
65                  70                  75                  80  


Glu Leu Met Thr Lys Lys Val Glu His Leu Ser Arg Leu His Pro Gln 
                85                  90                  95      


Tyr Pro Cys Arg Lys Glu Gly Lys Val Val Ser Pro Ile Ala Thr Thr 
            100                 105                 110         


Gly Val Arg Gly Lys Gln Glu Glu Lys Leu Arg Leu Leu Ser Pro Gln 
        115                 120                 125             


Lys Ser Pro Ala Val Lys Val Asn Arg Asp Arg Cys Phe Thr Thr Lys 
    130                 135                 140                 


Val Ile Pro Lys Ala Thr Lys Gln Glu Val Thr His Pro Ser Lys Gly 
145                 150                 155                 160 


Phe Phe Gly Pro Phe Pro Thr Val Gly Leu Asn Leu Val Ala Asp 
                165                 170                 175 


<210>  27
<211>  179
<212>  PRT
<213>  Canis lupus familiaris

<400>  27

Met Gln His Leu Leu Arg Pro Arg Gly Ser Gly Gly Leu Trp Leu Leu 
1               5                   10                  15      


Leu Cys Phe Leu Leu Pro Asn Ser Arg Pro Gly Gly Cys Ser Asp Thr 
            20                  25                  30          


Ser Gly His Asp Gly Gln Gly Gln Val Gly Val Gly Gln Phe Trp Ser 
        35                  40                  45              


Leu Pro Gly Phe Ala Thr Pro Val Phe Gln His Leu Gln Ala Val Phe 
    50                  55                  60                  


Gln Glu Ile Val Pro Gln Ala Leu Phe Trp Lys Asp Asp Ile Thr Gln 
65                  70                  75                  80  


Asp Val Met Ala Gln Lys Ile Glu Gln Ile Gly Arg Phe His Pro Gln 
                85                  90                  95      


Asp Pro Cys Leu Arg His Gly Gln Ala Ala Phe Pro Thr Lys Thr Thr 
            100                 105                 110         


Glu Val Met Ser Lys Gln Glu Glu Lys Leu Arg Leu Leu Leu Pro Lys 
        115                 120                 125             


Asn Ser Ser Gln Ser Pro Met Thr Lys Val Asn Arg Glu Gln Cys Phe 
    130                 135                 140                 


Thr Ser Lys Val Asp Leu Lys Thr Leu Glu Ile His Ile Lys Thr Pro 
145                 150                 155                 160 


Ile Val Lys Gly Phe Phe Glu Pro Pro Pro Thr Val Gly Arg His Leu 
                165                 170                 175     


Ile Ala Asp 
            


<210>  28
<211>  228
<212>  PRT
<213>  Gorilla gorilla

<400>  28

Met Ala Val Asp Val Glu Phe Arg Val Ala Gly Trp Trp Glu Ala Ala 
1               5                   10                  15      


Ala Pro Leu Ser Pro Ser Ala Val Ala Ala Ala Phe Thr Glu Thr Trp 
            20                  25                  30          


Pro Gly Ser Glu Arg Ala Glu Pro Gly Arg Ile Gln His Pro Leu Trp 
        35                  40                  45              


Pro Gly Ser Ser Glu Gly Leu Gln Leu Leu Val Cys Phe Leu Leu Leu 
    50                  55                  60                  


Asn Ser Cys Pro Gly Gly Cys Ser Asp Ile Ser Ala His Asp Gly Gln 
65                  70                  75                  80  


Asp Gln Val Gly Val Gly Gln Leu Trp Pro Leu Gln Gly Phe Ala Thr 
                85                  90                  95      


Pro Val Phe Gln His Leu Gln Val Val Leu Gln Gln Ile Ile Pro Gln 
            100                 105                 110         


Gly Leu Phe Trp Lys Asp Asp Ile Thr Gln Asp Ala Met Ile Gln Lys 
        115                 120                 125             


Met Glu His Ala Ser Arg Leu His Pro Gln Asp Pro Cys Leu Lys Asp 
    130                 135                 140                 


Gly Lys Ala Leu Phe Pro Thr Lys Thr Thr Glu Ser Pro Leu Ala Lys 
145                 150                 155                 160 


Val Asn Arg Asp Gln Cys Phe Thr Ser Lys Val Val Ser Lys Ala Leu 
                165                 170                 175     


Lys Gln Glu Val Ala Asn Pro Val Lys Ile Thr Tyr Arg Cys Ser Tyr 
            180                 185                 190         


Gly Gly Leu Asp Met Met Gln Ala Leu Gly Ala Ser Lys Glu Glu Ile 
        195                 200                 205             


Ile Tyr Lys Ile Met Arg Leu Leu Trp Ala Ile Ser Tyr Cys Gly Leu 
    210                 215                 220                 


Gln Pro Cys Gly 
225             


<210>  29
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Trp Thr Gly Tyr Lys Ile Leu Ile Phe Ser Tyr Leu Thr Thr Glu 
1               5                   10                  15      


Ile Trp Met Glu Lys Gln Tyr Leu Ser Gln Arg Glu Val Asp Leu Glu 
            20                  25                  30          


Ala Tyr Phe Thr Arg Asn His Thr Val Leu Gln Gly Thr Arg Phe Lys 
        35                  40                  45              


Arg Ala Ile Phe Gln Gly Gln Tyr Cys Arg Asn Phe Gly Cys Cys Glu 
    50                  55                  60                  


Asp Arg Asp Asp Gly Cys Val Thr Glu Phe Tyr Ala Ala Asn Ala Leu 
65                  70                  75                  80  


Cys Tyr Cys Asp Lys Phe Cys Asp Arg Glu Asn Ser Asp Cys Cys Pro 
                85                  90                  95      


Asp Tyr Lys Ser Phe Cys Arg Glu Glu Lys Glu Trp Pro Pro His Thr 
            100                 105                 110         


Gln Pro Trp Tyr Pro Glu Gly Cys Phe Lys Asp Gly Gln His Tyr Glu 
        115                 120                 125             


Glu Gly Ser Val Ile Lys Glu Asn Cys Asn Ser Cys Thr Cys Ser Gly 
    130                 135                 140                 


Gln Gln Trp Lys Cys Ser Gln His Val Cys Leu Val Arg Ser Glu Leu 
145                 150                 155                 160 


Ile Glu Gln Val Asn Lys Gly Asp Tyr Gly Trp Thr Ala Gln Asn Tyr 
                165                 170                 175     


Ser Gln Phe Trp Gly Met Thr Leu Glu Asp Gly Phe Lys Phe Arg Leu 
            180                 185                 190         


Gly Thr Leu Pro Pro Ser Pro Met Leu Leu Ser Met Asn Glu Met Thr 
        195                 200                 205             


Ala Ser Leu Pro Ala Thr Thr Asp Leu Pro Glu Phe Phe Val Ala Ser 
    210                 215                 220                 


Tyr Lys Trp Pro Gly Trp Thr His Gly Pro Leu Asp Gln Lys Asn Cys 
225                 230                 235                 240 


Ala Ala Ser Trp Ala Phe Ser Thr Ala Ser Val Ala Ala Asp Arg Ile 
                245                 250                 255     


Ala Ile Gln Ser Lys Gly Arg Tyr Thr Ala Asn Leu Ser Pro Gln Asn 
            260                 265                 270         


Leu Ile Ser Cys Cys Ala Lys Asn Arg His Gly Cys Asn Ser Gly Ser 
        275                 280                 285             


Ile Asp Arg Ala Trp Trp Tyr Leu Arg Lys Arg Gly Leu Val Ser His 
    290                 295                 300                 


Ala Cys Tyr Pro Leu Phe Lys Asp Gln Asn Ala Thr Asn Asn Gly Cys 
305                 310                 315                 320 


Ala Met Ala Ser Arg Ser Asp Gly Arg Gly Lys Arg His Ala Thr Lys 
                325                 330                 335     


Pro Cys Pro Asn Asn Val Glu Lys Ser Asn Arg Ile Tyr Gln Cys Ser 
            340                 345                 350         


Pro Pro Tyr Arg Val Ser Ser Asn Glu Thr Glu Ile Met Lys Glu Ile 
        355                 360                 365             


Met Gln Asn Gly Pro Val Gln Ala Ile Met Gln Val Arg Glu Asp Phe 
    370                 375                 380                 


Phe His Tyr Lys Thr Gly Ile Tyr Arg His Val Thr Ser Thr Asn Lys 
385                 390                 395                 400 


Glu Ser Glu Lys Tyr Arg Lys Leu Gln Thr His Ala Val Lys Leu Thr 
                405                 410                 415     


Gly Trp Gly Thr Leu Arg Gly Ala Gln Gly Gln Lys Glu Lys Phe Trp 
            420                 425                 430         


Ile Ala Ala Asn Ser Trp Gly Lys Ser Trp Gly Glu Asn Gly Tyr Phe 
        435                 440                 445             


Arg Ile Leu Arg Gly Val Asn Glu Ser Asp Ile Glu Lys Leu Ile Ile 
    450                 455                 460                 


Ala Ala Trp Gly Gln Leu Thr Ser Ser Asp Glu Pro 
465                 470                 475     


<210>  30
<211>  1804
<212>  DNA
<213>  Homo sapiens

<400>  30
gaagtatact cattcaagta aaggatcagt ttcagggttc aggctgaagt gtcttaatga       60

ctagaattca ggttccaagg agaagcccac aaggctaagg gtattggata taacggaaag      120

tggaagctat acctgacttc cagagaatgt ggaccggata taagatctta atcttctctt      180

atcttactac agaaatctgg atggagaagc agtatttatc tcaaagagaa gtggacctag      240

aggcttattt cactaggaat cacaccgttt tgcaaggtac tcgattcaaa agagccattt      300

tccaagggca atactgtaga aattttggct gttgtgaaga cagagatgat ggctgtgtca      360

ctgagttcta tgcggcgaat gcgttgtgct actgtgataa attctgtgac agagaaaatt      420

ctgattgctg tcctgactac aagtcctttt gccgtgaaga gaaagaatgg cctcctcaca      480

cacagccttg gtatccagaa ggttgcttca aagatggtca acattatgaa gagggatcag      540

taattaaaga aaactgcaac tcctgcacat gctcaggaca gcaatggaaa tgttcccagc      600

atgtatgcct tgttcgttca gaattaattg aacaggtcaa taaaggagac tatggatgga      660

cagcacagaa ttacagccaa ttttggggaa tgactttaga agatggtttt aaatttcgcc      720

ttggcacttt gccacctagt cccatgctcc tgagcatgaa tgaaatgaca gcttctttac      780

ctgcaacaac tgatcttcca gagttttttg ttgcttctta taaatggcct ggatggactc      840

atggcccatt ggatcaaaaa aattgtgctg catcctgggc attttccact gcaagtgtgg      900

ctgctgaccg aatagcaatt cagtctaagg gtcgatacac ggccaatcta tcccctcaga      960

atttgatctc ttgctgtgcc aagaaccgtc atggatgcaa tagtggaagc atcgataggg     1020

cttggtggta cctgagaaaa cgtggactgg tatcccacgc atgctaccca cttttcaaag     1080

accaaaatgc taccaacaat ggatgtgcca tggcaagcag gtctgatggg cgaggaaaac     1140

ggcatgccac gaagccatgt cccaacaacg tagaaaaatc taacaggatc tatcaatgtt     1200

ctcctccata cagagtctct tccaacgaaa ctgagataat gaaagaaatc atgcaaaatg     1260

gaccagttca agccataatg caagtccgtg aagatttctt ccattataag acagggatat     1320

acagacatgt taccagcaca aataaagaat cagaaaaata tcgaaagctt cagacacatg     1380

cagtcaaact cactggatgg ggcacactga gaggagcaca agggcagaaa gaaaaatttt     1440

ggattgctgc caattcctgg ggaaagtcat ggggagagaa tggctatttc aggattcttc     1500

gaggagtaaa tgagtccgac attgaaaagt tgattatcgc agcttggggc caactgacga     1560

gttctgatga accataacat atcattaaat ttccataagg tcatgccttt aagtaacccc     1620

ctaaattgaa gtttagcaat atgacattct tggtgacagt ggaatctttg tctcttcacc     1680

gtgttaacat aatctatcta ttttcttatt ttcccctctg gtctatgctt ctgcttcctt     1740

catattactg agcattaaca acaccaataa aggacagcag agtccctaaa tgtctttaaa     1800

gttc                                                                  1804


<210>  31
<211>  475
<212>  PRT
<213>  Mus musculus

<400>  31

Met Trp Thr Gly Tyr Lys Ile Leu Ile Phe Phe Ser Leu Thr Thr Asp 
1               5                   10                  15      


Ile Cys Thr Glu Thr His Phe Ser Gln Gly Glu Ala Glu Pro Gly Pro 
            20                  25                  30          


Arg Phe Thr Arg Asn His Thr Ile Phe Glu Gly Ser Arg His Lys Arg 
        35                  40                  45              


Ala Ile Phe Gln Gly Glu Tyr Cys Arg Arg Phe Gly Cys Cys Glu Ala 
    50                  55                  60                  


Arg Asp Asp Thr Cys Val Thr Gln Phe Tyr Glu Ala Asn Ala Leu Cys 
65                  70                  75                  80  


Tyr Cys Asp Ser Phe Cys Glu Arg Asp Thr Ser Asp Cys Cys Pro Asp 
                85                  90                  95      


Tyr Lys Ser Phe Cys His Glu Glu Lys Glu Glu Pro Pro Phe Gln Gln 
            100                 105                 110         


Pro Ser Asp Pro Glu Gly Cys Phe Arg Asp Ser Gln His Tyr Glu Glu 
        115                 120                 125             


Gly Ser Val Val Lys Glu Asn Cys Asn Ser Cys Thr Cys Ser Gly Gln 
    130                 135                 140                 


Gln Trp Lys Cys Ser Gln His Val Cys Leu Val His Pro Glu Leu Ile 
145                 150                 155                 160 


Asp His Ile Asn Lys Gly Asp Tyr Gly Trp Thr Ala Gln Asn Tyr Ser 
                165                 170                 175     


Gln Phe Trp Gly Met Thr Leu Glu Glu Gly Phe Lys Phe Arg Leu Gly 
            180                 185                 190         


Thr Leu Pro Pro Ser Pro Met Leu Leu Ser Met Asn Glu Met Thr Ala 
        195                 200                 205             


Ser Phe Pro Pro Arg Ala Asp Leu Pro Glu Ile Phe Ile Ala Ser Tyr 
    210                 215                 220                 


Lys Trp Pro Gly Trp Thr His Gly Pro Leu Asp Gln Lys Asn Cys Ala 
225                 230                 235                 240 


Ala Ser Trp Ala Phe Ser Thr Ala Ser Val Ala Ala Asp Arg Ile Ala 
                245                 250                 255     


Ile Gln Ser Lys Gly Arg Tyr Thr Ala Asn Leu Ser Pro Gln Asn Leu 
            260                 265                 270         


Ile Ser Cys Cys Ala Lys Asn Arg His Gly Cys Asn Ser Gly Ser Ile 
        275                 280                 285             


Asp Arg Ala Trp Trp Phe Leu Arg Lys Arg Gly Leu Val Ser His Ala 
    290                 295                 300                 


Cys Tyr Pro Leu Phe Lys Asp Gln Asn Thr Thr Asn Asn Ile Cys Ala 
305                 310                 315                 320 


Met Ala Ser Arg Ser Asp Gly Arg Gly Lys Arg His Ala Thr Lys Pro 
                325                 330                 335     


Cys Pro Asn Ser Phe Glu Lys Ser Asn Arg Ile Tyr Gln Cys Ser Pro 
            340                 345                 350         


Pro Tyr Arg Val Ser Ser Asn Glu Thr Glu Ile Met Arg Glu Ile Ile 
        355                 360                 365             


Gln Asn Gly Pro Val Gln Ala Ile Met Gln Val His Glu Asp Phe Phe 
    370                 375                 380                 


Tyr Tyr Lys Thr Gly Ile Tyr Arg His Val Val Ser Thr Asn Glu Glu 
385                 390                 395                 400 


Pro Glu Lys Tyr Lys Lys Leu Arg Thr His Ala Val Lys Leu Thr Gly 
                405                 410                 415     


Trp Gly Thr Leu Arg Gly Ala Arg Gly Lys Lys Glu Lys Phe Trp Ile 
            420                 425                 430         


Ala Ala Asn Ser Trp Gly Lys Ser Trp Gly Glu Asn Gly Tyr Phe Arg 
        435                 440                 445             


Ile Leu Arg Gly Val Asn Glu Ser Asp Ile Glu Lys Leu Ile Ile Ala 
    450                 455                 460                 


Ala Trp Gly Gln Leu Thr Ser Ser Asp Asp Pro 
465                 470                 475 


<210>  32
<211>  1708
<212>  DNA
<213>  Mus musculus

<400>  32
gagcaggctt caaagaaaaa aatccccaag actaaaagaa tcaggtgcag ttgaaagagg       60

aagctgaacc aacaaacaat aatgtggact ggatataaga tcttaatctt cttctctctg      120

acgacagaca tctgcactga gactcatttc tctcaaggag aagcagaacc agggccaaga      180

ttcactagaa atcacaccat ttttgaaggt tctcggcaca aaagggccat tttccaaggg      240

gaatactgta ggcgctttgg ctgttgtgaa gctagagatg acacctgtgt cactcagttc      300

tatgaggcca atgcactgtg ttactgtgac agcttctgtg agcgggacac ctctgattgc      360

tgtcctgatt acaagtcatt ctgccacgaa gaaaaagaag agcctccttt ccaacagcct      420

tcagacccag aaggttgctt cagagatagc cagcattatg aagaaggatc agtagttaaa      480

gaaaactgca actcctgtac atgttcagga cagcagtgga aatgttccca acatgtgtgc      540

cttgttcatc cagaattaat tgaccacatc aataaaggag actatggatg gacagcacag      600

aattatagcc aattctgggg aatgacctta gaagaaggat tcaaattccg cctcggcacc      660

ttgccaccta gccccatgct tctcagcatg aatgaaatga cagcttcttt tcctcccaga      720

gctgatcttc ctgagatctt cattgcttct tataagtggc ctggatggac tcatggtcca      780

ctggatcaaa aaaactgtgc tgcatcctgg gctttttcca ccgcaagtgt ggcagctgac      840

cgaattgcaa ttcagtccaa gggtcgatac acagccaatc tctcgcctca gaatttgatc      900

tcttgttgtg ccaagaatcg tcacggatgc aacagtggaa gcatagatag ggcctggtgg      960

ttcctgagaa aacgtggact ggtatctcat gcatgctacc cacttttcaa ggaccaaaac     1020

actaccaata atatctgtgc tatggcaagt agatcagatg ggcggggaaa acggcatgcc     1080

acaaagccat gtcccaacag cttcgagaaa tccaacagga tttaccaatg ttctcctcca     1140

tacagagtct cttccaatga aactgaaatt atgagagaaa tcatacaaaa tggaccagtt     1200

caagccataa tgcaagtcca tgaagacttc ttttattata agacaggaat atacagacat     1260

gttgtcagca caaatgaaga accagaaaag tataaaaaac ttcggacaca tgcagttaaa     1320

ctcactggat ggggcacact gagaggagca cgaggaaaaa aagaaaaatt ttggattgct     1380

gccaattcct ggggaaagtc atggggagag aatggctatt ttaggattct tcgaggagta     1440

aatgaatctg acattgagaa attgattatc gcagcgtggg gccaactgac aagttcagat     1500

gatccatagc tatcacattt ccataaggtc atgcattcaa gtaactcatt aaatcgaatt     1560

ttagcaatcc aaggttccct gagccagagg aagggtgcat ttttgctatg tgcgtaggac     1620

attcctcctt tcttgtttta ctccagactc taatccgttc tctttatatt attaaaatac     1680

taataaaaga aagaatggct aaatgtca                                        1708


<210>  33
<211>  476
<212>  PRT
<213>  Pan troglodytes

<400>  33

Met Trp Thr Gly Tyr Lys Ile Leu Ile Phe Ser Tyr Leu Thr Thr Glu 
1               5                   10                  15      


Ile Trp Met Glu Lys Gln Tyr Leu Ser Gln Arg Glu Val Asp Leu Glu 
            20                  25                  30          


Ala Tyr Phe Thr Arg Asn His Thr Val Leu Gln Gly Thr Arg Phe Lys 
        35                  40                  45              


Arg Ala Ile Phe Gln Gly Gln Tyr Cys Arg Asn Phe Gly Cys Cys Glu 
    50                  55                  60                  


Asp Arg Asp Asp Gly Cys Val Thr Glu Phe Tyr Ala Ala Asn Ala Leu 
65                  70                  75                  80  


Cys Tyr Cys Asp Lys Phe Cys Asp Arg Glu Asn Ser Asp Cys Cys Pro 
                85                  90                  95      


Asp Tyr Lys Ser Phe Cys Arg Glu Glu Lys Glu Trp Pro Pro His Thr 
            100                 105                 110         


Gln Pro Trp Tyr Pro Glu Gly Cys Phe Lys Asp Gly Gln His Tyr Glu 
        115                 120                 125             


Glu Gly Ser Val Ile Lys Glu Asn Cys Asn Ser Cys Thr Cys Ser Gly 
    130                 135                 140                 


Gln Gln Trp Lys Cys Ser Gln His Val Cys Leu Val His Pro Glu Leu 
145                 150                 155                 160 


Ile Glu Gln Val Asn Lys Gly Asp Tyr Gly Trp Thr Ala Gln Asn Tyr 
                165                 170                 175     


Ser Gln Phe Trp Gly Met Thr Leu Glu Asp Gly Phe Lys Phe Arg Leu 
            180                 185                 190         


Gly Thr Leu Pro Pro Ser Pro Met Leu Leu Ser Met Asn Glu Met Thr 
        195                 200                 205             


Ala Ser Leu Pro Ala Thr Thr Asp Leu Pro Glu Phe Phe Val Ala Ser 
    210                 215                 220                 


Tyr Lys Trp Pro Gly Trp Thr His Gly Pro Leu Asp Gln Lys Asn Cys 
225                 230                 235                 240 


Ala Ala Ser Trp Ala Phe Ser Thr Ala Ser Val Ala Ala Asp Arg Ile 
                245                 250                 255     


Ala Ile Gln Ser Lys Gly Arg Tyr Thr Ala Asn Leu Ser Pro Gln Asn 
            260                 265                 270         


Leu Ile Ser Cys Cys Ala Lys Asn Arg His Gly Cys Asn Ser Gly Ser 
        275                 280                 285             


Ile Asp Arg Ala Trp Trp Tyr Leu Arg Lys Arg Gly Leu Val Ser His 
    290                 295                 300                 


Ala Cys Tyr Pro Leu Phe Lys Asp His Asn Ala Thr Asn Asn Gly Cys 
305                 310                 315                 320 


Ala Met Ala Ser Arg Ser Asp Gly Arg Gly Lys Arg His Ala Thr Lys 
                325                 330                 335     


Pro Cys Pro Asn Asn Val Glu Lys Ser Asn Arg Ile Tyr Gln Cys Ser 
            340                 345                 350         


Pro Pro Tyr Arg Val Ser Ser Asn Glu Thr Glu Ile Met Lys Glu Ile 
        355                 360                 365             


Met Gln Asn Gly Pro Val Gln Ala Ile Met Gln Val Arg Glu Asp Phe 
    370                 375                 380                 


Phe His Tyr Lys Thr Gly Ile Tyr Arg His Val Thr Ser Thr Asn Lys 
385                 390                 395                 400 


Glu Ser Glu Lys Tyr Arg Lys Leu Gln Thr His Ala Val Lys Leu Thr 
                405                 410                 415     


Gly Trp Gly Thr Leu Arg Gly Ala Gln Gly Gln Lys Glu Lys Phe Trp 
            420                 425                 430         


Ile Ala Ala Asn Ser Trp Gly Lys Ser Trp Gly Glu Asn Gly Tyr Phe 
        435                 440                 445             


Arg Ile Leu Arg Gly Val Asn Glu Ser Asp Ile Glu Lys Leu Ile Ile 
    450                 455                 460                 


Ala Ala Trp Gly Gln Leu Thr Ser Ser Asp Glu Pro 
465                 470                 475     


<210>  34
<211>  476
<212>  PRT
<213>  Canis lupus familiaris

<400>  34

Met Trp Thr Gly Tyr Lys Ile Leu Ile Phe Ser Tyr Leu Thr Thr Glu 
1               5                   10                  15      


Ile Trp Met Glu Lys Arg Tyr Val Ser Gln Arg Glu Val Asn Pro Gly 
            20                  25                  30          


Thr Ala Phe Thr Arg Asn His Thr Ile Leu Glu Gly Thr Arg Phe Lys 
        35                  40                  45              


Arg Ala Ile Phe Lys Gly Gln Tyr Cys Arg Ser Phe Gly Cys Cys Glu 
    50                  55                  60                  


Asp Arg Asp Asp Asp Cys Val Thr His Phe Tyr Glu Ala Asn Ala Leu 
65                  70                  75                  80  


Cys Tyr Cys Asp Asn Phe Cys Glu Arg Glu Asn Ser Asp Cys Cys Pro 
                85                  90                  95      


Asp Tyr Lys Ser Phe Cys His Glu Glu Lys Glu Trp Pro Pro His Ile 
            100                 105                 110         


Lys Pro Trp Asp Pro Glu Gly Cys Phe Arg Asp Gly Gln Leu Tyr Glu 
        115                 120                 125             


Glu Gly Ser Val Ile Lys Glu Asn Cys Asn Ser Cys Thr Cys Ser Gly 
    130                 135                 140                 


Gln Gln Trp Lys Cys Ser Gln Leu Val Cys Leu Val Gln Pro Glu Leu 
145                 150                 155                 160 


Ile Glu His Val Asn Lys Gly Asp Tyr Gly Trp Thr Ala Gln Asn Tyr 
                165                 170                 175     


Ser Gln Phe Trp Gly Met Thr Leu Glu Glu Gly Phe Lys Tyr Arg Leu 
            180                 185                 190         


Gly Thr Leu Pro Pro Ser Pro Met Leu Leu Ser Met Asn Glu Met Thr 
        195                 200                 205             


Ala Ser Leu Pro Ala Thr Thr Asp Leu Pro Glu Phe Phe Ile Ala Ser 
    210                 215                 220                 


Tyr Lys Trp Pro Gly Trp Thr His Gly Pro Leu Asp Gln Lys Asn Cys 
225                 230                 235                 240 


Ala Ala Ser Trp Ala Phe Ser Thr Ala Ser Val Ala Ala Asp Arg Ile 
                245                 250                 255     


Ala Ile Gln Ser Asn Gly Arg Tyr Thr Ala Asn Leu Ser Pro Gln Asn 
            260                 265                 270         


Leu Ile Ser Cys Cys Ala Lys Asn Arg His Gly Cys Asn Ser Gly Ser 
        275                 280                 285             


Ile Asp Arg Ala Trp Trp Phe Leu Arg Lys Arg Gly Leu Val Ser His 
    290                 295                 300                 


Ala Cys Tyr Pro Leu Phe Lys Asp Gln Asn Ala Thr Asn Tyr Gly Cys 
305                 310                 315                 320 


Ala Met Ala Ser Arg Ser Asp Gly Arg Gly Lys Arg His Ala Thr Lys 
                325                 330                 335     


Pro Cys Pro Asn Asn Ile Glu Lys Ser Asn Arg Ile Tyr Gln Cys Ser 
            340                 345                 350         


Pro Pro Tyr Arg Val Ser Ser Asn Glu Thr Glu Ile Met Lys Glu Ile 
        355                 360                 365             


Met Gln Asn Gly Pro Val Gln Ala Ile Met Gln Val His Glu Asp Phe 
    370                 375                 380                 


Phe His Tyr Lys Thr Gly Ile Tyr Arg His Ile Thr Arg Thr Asn Glu 
385                 390                 395                 400 


Glu Ser Arg Lys Tyr Gln Lys Leu Gln Thr His Ala Val Lys Leu Thr 
                405                 410                 415     


Gly Trp Gly Thr Leu Lys Gly Ala Gln Gly Gln Lys Glu Lys Phe Trp 
            420                 425                 430         


Ile Ala Ala Asn Ser Trp Gly Ile Ser Trp Gly Glu Asn Gly Tyr Phe 
        435                 440                 445             


Arg Ile Leu Arg Gly Val Asn Glu Ser Asp Ile Glu Lys Leu Ile Ile 
    450                 455                 460                 


Ala Ala Trp Gly His Leu Thr Ser Ser Asp Glu Pro 
465                 470                 475     


<210>  35
<211>  475
<212>  PRT
<213>  Rattus norvegicus

<400>  35

Met Trp Ile Gly Tyr Lys Ile Leu Ile Phe Phe Ser Leu Met Thr Glu 
1               5                   10                  15      


Ile Cys Ala Gly Thr His Tyr Leu Ser Gly Gly Glu Val Asp Pro Gly 
            20                  25                  30          


Leu Ser Phe Thr Arg Asn His Thr Ser Phe Glu Gly Thr Arg His Lys 
        35                  40                  45              


Arg Ala Ile Phe Gln Gly Glu Tyr Cys Arg Arg Phe Gly Cys Cys Glu 
    50                  55                  60                  


Ala Arg Asp Asp Thr Cys Val Thr Gln Phe Tyr Glu Ala Asn Ala Leu 
65                  70                  75                  80  


Cys Tyr Cys Asp Ser Phe Cys Glu Arg Asp Thr Ser Asp Cys Cys Pro 
                85                  90                  95      


Asp Tyr Lys Ser Phe Cys Arg Glu Gly Lys Asp Gly Pro Pro Leu Gln 
            100                 105                 110         


Gln Pro Leu Asp Pro Glu Gly Cys Ser Arg Asp Ser Gln His Tyr Glu 
        115                 120                 125             


Glu Gly Ser Val Ile Lys Glu Asn Cys Asn Phe Cys Thr Cys Ser Gly 
    130                 135                 140                 


Gln Gln Trp Lys Cys Ser Gln His Val Cys Leu Val Leu Pro Glu Leu 
145                 150                 155                 160 


Ile Asp His Ile Asn Lys Gly Asp Tyr Gly Trp Thr Ala Gln Asn Tyr 
                165                 170                 175     


Ser Gln Phe Trp Gly Met Thr Leu Glu Glu Gly Phe Lys Phe Arg Leu 
            180                 185                 190         


Gly Thr Leu Pro Pro Ser Pro Met Leu Leu Ser Met Asn Glu Met Thr 
        195                 200                 205             


Ala Ser Tyr Pro Arg Ala Asp Leu Pro Glu Val Phe Ile Ala Ser Tyr 
    210                 215                 220                 


Lys Trp Pro Gly Trp Thr His Gly Pro Leu Asp Gln Lys Asn Cys Ala 
225                 230                 235                 240 


Ala Ser Trp Ala Phe Ser Thr Ala Ser Val Ala Ala Asp Arg Ile Ala 
                245                 250                 255     


Ile Gln Ser Lys Gly Arg Tyr Thr Ala Asn Leu Ser Pro Gln Asn Leu 
            260                 265                 270         


Ile Ser Cys Cys Ala Lys Asn Arg His Gly Cys Asn Ser Gly Ser Ile 
        275                 280                 285             


Asp Arg Ala Trp Trp Phe Leu Arg Lys Arg Gly Leu Val Ser His Ala 
    290                 295                 300                 


Cys Tyr Pro Leu Phe Lys Glu Gln Ser Thr Asn Asn Asn Ser Cys Ala 
305                 310                 315                 320 


Met Ala Ser Arg Ser Asp Gly Arg Gly Lys Arg His Ala Thr Arg Pro 
                325                 330                 335     


Cys Pro Asn Ser Phe Glu Lys Ser Asn Arg Ile Tyr Gln Cys Ser Pro 
            340                 345                 350         


Pro Tyr Arg Ile Ser Ser Asn Glu Thr Glu Ile Met Arg Glu Ile Ile 
        355                 360                 365             


Gln Asn Gly Pro Val Gln Ala Ile Met Gln Val His Glu Asp Phe Phe 
    370                 375                 380                 


Tyr Tyr Lys Thr Gly Ile Tyr Arg His Val Val Ser Thr Asn Glu Glu 
385                 390                 395                 400 


Pro Glu Lys Tyr Arg Lys Leu Arg Thr His Ala Val Lys Leu Thr Gly 
                405                 410                 415     


Trp Gly Thr Leu Arg Gly Ala Gln Gly Lys Lys Glu Lys Phe Trp Ile 
            420                 425                 430         


Ala Ala Asn Ser Trp Gly Lys Ser Trp Gly Glu Asn Gly Tyr Phe Arg 
        435                 440                 445             


Ile Leu Arg Gly Val Asn Glu Ser Asp Ile Glu Lys Leu Ile Ile Ala 
    450                 455                 460                 


Ala Trp Gly Gln Leu Thr Ser Ser Asp Asp Pro 
465                 470                 475 


<210>  36
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is N or T.

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  In some cases, Xaa comprises a CONH2 group instead of a carboxyl 
       group.

<400>  36

Cys Trp Xaa Phe Cys Gln Ala 
1               5           


<210>  37
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is A or T.

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is A or T.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is I or M.

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is K, Q, or H.

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is S, K, or R.

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is E or G.

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is S or A.

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is S or G.

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is F or L. In some cases, Xaa comprises a CONH2 group instead
       of a carboxyl group.

<400>  37

Pro Gly Val Tyr Thr Gln Val Xaa Lys Phe Leu Asn Trp Ile Lys Xaa 
1               5                   10                  15      


Thr Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  


<210>  38
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is L or M.

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is E or D.

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  In some cases, Xaa comprises a CONH2 group instead of a carboxyl 
       group.

<400>  38

Gly Trp Xaa Arg Leu Leu Ala Glu Gly Glu Gly Cys Ala Pro Cys Arg 
1               5                   10                  15      


Pro Glu Xaa Cys Ala Ala Pro Arg Gly Cys Leu Ala 
            20                  25              


<210>  39
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is D or E.

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is R or Q.

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is T or S.

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is K or E.

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is I, D, or V.

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is P, L, or S.

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is A or T.

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is T or L.

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is K or E.

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is I or Q.

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is E or H.

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is A, V, or I.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is T, K, or A.

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is H, T, or N.

<220>
<221>  MISC_FEATURE
<222>  (21)..(25)
<223>  Xaa at these positions can be any amino acid and can be present 
       or absent. This region can have from 1 to 5 total amino acids. In
       some cases, this region is T, S, IV, or VKITY.

<220>
<221>  MISC_FEATURE
<222>  (21)..(25)
<223>  In some cases, the C-terminal residue is modified to comprise a 
       CONH2 group instead of a carboxyl group.

<400>  39

Xaa Xaa Cys Phe Thr Xaa Xaa Val Xaa Xaa Lys Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Pro Xaa Xaa Xaa Xaa Xaa 
            20                  25  


<210>  40
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  40

Val Lys Ile Thr Tyr 
1               5   


<210>  41
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is R, Q, or K. In some cases, Xaa is R or Q.

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is R, Q, or K. In some cases, Xaa is R or K.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is R, Q, or K. In some cases, Xaa is R or Q.

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  In some cases, Xaa is a semi-conserved residue. In some cases, 
       Xaa is R, Q, or K. In some cases, Xaa is Q or K.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  In some cases, Xaa comprises a CONH2 group instead of a carboxyl 
       group.

<400>  41

Leu Xaa Thr His Ala Val Lys Leu Thr Gly Trp Gly Thr Leu Xaa Gly 
1               5                   10                  15      


Ala Xaa Gly Xaa Lys Glu Lys Phe Trp Ile Ala Ala Asn Ser Trp Gly 
            20                  25                  30          


<210>  42
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  42

Leu Gln Thr His Ala Val Lys Leu Thr Gly Trp Gly Thr Leu Arg Gly 
1               5                   10                  15      


Ala Gln Gly Gln Lys Glu Lys Phe Trp Ile Ala Ala Asn Ser Trp Gly 
            20                  25                  30          


<210>  43
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa comprises a CONH2 group instead of a carboxyl group.

<400>  43

Leu Gln Thr His Ala Val Lys Leu Thr Gly Trp Gly Thr Leu Arg Gly 
1               5                   10                  15      


Ala Gln Gly Gln Lys Glu Lys Phe Trp Ile Ala Ala Asn Ser Trp 
            20                  25                  30      


<210>  44
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  44

Leu Arg Thr His Ala Val Lys Leu Thr Gly Trp Gly Thr Leu Arg Gly 
1               5                   10                  15      


Ala Arg Gly Lys Lys Glu Lys Phe Trp Ile Ala Ala Asn Ser Trp Gly 
            20                  25                  30          


<210>  45
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa comprises a CONH2 group instead of a carboxyl group.

<400>  45

Leu Arg Thr His Ala Val Lys Leu Thr Gly Trp Gly Thr Leu Arg Gly 
1               5                   10                  15      


Ala Arg Gly Lys Lys Glu Lys Phe Trp Ile Ala Ala Asn Ser Trp 
            20                  25                  30      


<210>  46
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  46

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  47
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  47

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  48
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  48

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  49
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  49

Lys Ala Leu Ala Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala 
1               5                   10                  15      


Leu Ala Lys His Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu 
            20                  25                  30          


Ala 
    


<210>  50
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  50

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  51
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  51

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  52
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  52

Arg Lys Lys Arg Arg Gln Arg Arg 
1               5               


<210>  53
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  53

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  54
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  54

Thr His Arg Leu Pro Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  55
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  55

Gly Gly Arg Arg Ala Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  56
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  56

Cys Trp Asn Phe Cys Gln Ala 
1               5           


<210>  57
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  57

Cys Trp Thr Phe Cys Gln Ala 
1               5           


<210>  58
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  58

Pro Gly Val Tyr Thr Gln Val Thr Lys Phe Leu Asn Trp Ile Lys Ala 
1               5                   10                  15      


Thr Ile Lys Ser Glu Ser Gly Phe 
            20                  


<210>  59
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  59

Pro Gly Val Tyr Thr Gln Val Ala Lys Phe Leu Asn Trp Ile Lys Ala 
1               5                   10                  15      


Thr Ile Gln Lys Gly Ser Ser Phe 
            20                  


<210>  60
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  60

Pro Gly Val Tyr Thr Gln Val Thr Lys Phe Leu Asn Trp Ile Lys Thr 
1               5                   10                  15      


Thr Met His Arg Glu Ala Gly Leu 
            20                  


<210>  61
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  61

Pro Gly Val Tyr Thr Gln Val Thr Lys Phe Leu Asn Trp Ile Lys Thr 
1               5                   10                  15      


Thr Met His Lys Glu Ala Gly Leu 
            20                  


<210>  62
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  62

Gly Trp Leu Arg Leu Leu Ala Glu Gly Glu Gly Cys Ala Pro Cys Arg 
1               5                   10                  15      


Pro Glu Glu Cys Ala Ala Pro Arg Gly Cys Leu Ala 
            20                  25              


<210>  63
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  63

Gly Trp Met Arg Leu Leu Ala Glu Gly Glu Gly Cys Ala Pro Cys Arg 
1               5                   10                  15      


Pro Glu Glu Cys Ala Ala Pro Arg Gly Cys Leu Ala 
            20                  25              


<210>  64
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  64

Asp Arg Cys Phe Thr Thr Lys Val Ile Pro Lys Ala Thr Lys Gln Glu 
1               5                   10                  15      


Ala Thr His Pro Thr 
            20      


<210>  65
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  65

Asp Arg Cys Phe Thr Thr Lys Val Ile Pro Lys Ala Thr Lys Gln Glu 
1               5                   10                  15      


Val Thr His Pro Ser 
            20      


<210>  66
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  66

Glu Gln Cys Phe Thr Ser Lys Val Asp Leu Lys Thr Leu Glu Ile His 
1               5                   10                  15      


Ile Lys Thr Pro Ile Val 
            20          


<210>  67
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  67

Asp Gln Cys Phe Thr Ser Lys Val Val Ser Lys Ala Leu Lys Gln Glu 
1               5                   10                  15      


Val Ala Asn Pro Val Lys Ile Thr Tyr Arg 
            20                  25      


<210>  68
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  68

Asp Gln Cys Phe Thr Ser Glu Val Val Ser Lys Ala Leu Lys Gln Glu 
1               5                   10                  15      


Val Ala Asn Pro Val Lys Ile Thr Tyr 
            20                  25  


<210>  69
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  69

Gly Ser Gly Gly Ser 
1               5   


<210>  70
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  70

Gly Gly Gly Ser 
1               


<210>  71
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  71

Gly Gly Ser Gly 
1               


<210>  72
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  72

Gly Gly Ser Gly Gly 
1               5   


<210>  73
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  73

Gly Ser Gly Ser Gly 
1               5   


<210>  74
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  74

Gly Ser Gly Gly Gly 
1               5   


<210>  75
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  75

Gly Gly Gly Ser Gly 
1               5   


<210>  76
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  76

Gly Ser Ser Ser Gly 
1               5   


