                         SEQUENCE LISTING

<110>  OXFORD NANOPORE TECHNOLOGIES LIMITED
 
<120>  ENZYME CONSTRUCT

<130>  N115953B-WO

<150>  US 61/673,446
<151>  2012-07-19

<150>  US 61/774,694
<151>  2013-03-08

<160>  115   

<170>  PatentIn version 3.5

<210>  1
<211>  558
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mycobacterium smegmatis porin A mutant 
       (D90N/D91N/D93N/D118R/D134R/E139K)

<400>  1
atgggtctgg ataatgaact gagcctggtg gacggtcaag atcgtaccct gacggtgcaa       60

caatgggata cctttctgaa tggcgttttt ccgctggatc gtaatcgcct gacccgtgaa      120

tggtttcatt ccggtcgcgc aaaatatatc gtcgcaggcc cgggtgctga cgaattcgaa      180

ggcacgctgg aactgggtta tcagattggc tttccgtggt cactgggcgt tggtatcaac      240

ttctcgtaca ccacgccgaa tattctgatc aacaatggta acattaccgc accgccgttt      300

ggcctgaaca gcgtgattac gccgaacctg tttccgggtg ttagcatctc tgcccgtctg      360

ggcaatggtc cgggcattca agaagtggca acctttagtg tgcgcgtttc cggcgctaaa      420

ggcggtgtcg cggtgtctaa cgcccacggt accgttacgg gcgcggccgg cggtgtcctg      480

ctgcgtccgt tcgcgcgcct gattgcctct accggcgaca gcgttacgac ctatggcgaa      540

ccgtggaata tgaactaa                                                    558


<210>  2
<211>  184
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mycobacterium smegmatis porin A mutant 
       (D90N/D91N/D93N/D118R/D134R/E139K)

<400>  2

Gly Leu Asp Asn Glu Leu Ser Leu Val Asp Gly Gln Asp Arg Thr Leu 
1               5                   10                  15      


Thr Val Gln Gln Trp Asp Thr Phe Leu Asn Gly Val Phe Pro Leu Asp 
            20                  25                  30          


Arg Asn Arg Leu Thr Arg Glu Trp Phe His Ser Gly Arg Ala Lys Tyr 
        35                  40                  45              


Ile Val Ala Gly Pro Gly Ala Asp Glu Phe Glu Gly Thr Leu Glu Leu 
    50                  55                  60                  


Gly Tyr Gln Ile Gly Phe Pro Trp Ser Leu Gly Val Gly Ile Asn Phe 
65                  70                  75                  80  


Ser Tyr Thr Thr Pro Asn Ile Leu Ile Asn Asn Gly Asn Ile Thr Ala 
                85                  90                  95      


Pro Pro Phe Gly Leu Asn Ser Val Ile Thr Pro Asn Leu Phe Pro Gly 
            100                 105                 110         


Val Ser Ile Ser Ala Arg Leu Gly Asn Gly Pro Gly Ile Gln Glu Val 
        115                 120                 125             


Ala Thr Phe Ser Val Arg Val Ser Gly Ala Lys Gly Gly Val Ala Val 
    130                 135                 140                 


Ser Asn Ala His Gly Thr Val Thr Gly Ala Ala Gly Gly Val Leu Leu 
145                 150                 155                 160 


Arg Pro Phe Ala Arg Leu Ile Ala Ser Thr Gly Asp Ser Val Thr Thr 
                165                 170                 175     


Tyr Gly Glu Pro Trp Asn Met Asn 
            180                 


<210>  3
<211>  885
<212>  DNA
<213>  Artificial sequence

<220>
<223>  alpha-hemolysin mutant E111N/K147N

<400>  3
atggcagatt ctgatattaa tattaaaacc ggtactacag atattggaag caatactaca       60

gtaaaaacag gtgatttagt cacttatgat aaagaaaatg gcatgcacaa aaaagtattt      120

tatagtttta tcgatgataa aaatcacaat aaaaaactgc tagttattag aacaaaaggt      180

accattgctg gtcaatatag agtttatagc gaagaaggtg ctaacaaaag tggtttagcc      240

tggccttcag cctttaaggt acagttgcaa ctacctgata atgaagtagc tcaaatatct      300

gattactatc caagaaattc gattgataca aaaaactata tgagtacttt aacttatgga      360

ttcaacggta atgttactgg tgatgataca ggaaaaattg gcggccttat tggtgcaaat      420

gtttcgattg gtcatacact gaactatgtt caacctgatt tcaaaacaat tttagagagc      480

ccaactgata aaaaagtagg ctggaaagtg atatttaaca atatggtgaa tcaaaattgg      540

ggaccatacg atcgagattc ttggaacccg gtatatggca atcaactttt catgaaaact      600

agaaatggtt ctatgaaagc agcagataac ttccttgatc ctaacaaagc aagttctcta      660

ttatcttcag ggttttcacc agacttcgct acagttatta ctatggatag aaaagcatcc      720

aaacaacaaa caaatataga tgtaatatac gaacgagttc gtgatgatta ccaattgcat      780

tggacttcaa caaattggaa aggtaccaat actaaagata aatggacaga tcgttcttca      840

gaaagatata aaatcgattg ggaaaaagaa gaaatgacaa attaa                      885


<210>  4
<211>  293
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha-hemolysin mutant E111N/K147N

<400>  4

Ala Asp Ser Asp Ile Asn Ile Lys Thr Gly Thr Thr Asp Ile Gly Ser 
1               5                   10                  15      


Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn 
            20                  25                  30          


Gly Met His Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp Lys Asn His 
        35                  40                  45              


Asn Lys Lys Leu Leu Val Ile Arg Thr Lys Gly Thr Ile Ala Gly Gln 
    50                  55                  60                  


Tyr Arg Val Tyr Ser Glu Glu Gly Ala Asn Lys Ser Gly Leu Ala Trp 
65                  70                  75                  80  


Pro Ser Ala Phe Lys Val Gln Leu Gln Leu Pro Asp Asn Glu Val Ala 
                85                  90                  95      


Gln Ile Ser Asp Tyr Tyr Pro Arg Asn Ser Ile Asp Thr Lys Asn Tyr 
            100                 105                 110         


Met Ser Thr Leu Thr Tyr Gly Phe Asn Gly Asn Val Thr Gly Asp Asp 
        115                 120                 125             


Thr Gly Lys Ile Gly Gly Leu Ile Gly Ala Asn Val Ser Ile Gly His 
    130                 135                 140                 


Thr Leu Asn Tyr Val Gln Pro Asp Phe Lys Thr Ile Leu Glu Ser Pro 
145                 150                 155                 160 


Thr Asp Lys Lys Val Gly Trp Lys Val Ile Phe Asn Asn Met Val Asn 
                165                 170                 175     


Gln Asn Trp Gly Pro Tyr Asp Arg Asp Ser Trp Asn Pro Val Tyr Gly 
            180                 185                 190         


Asn Gln Leu Phe Met Lys Thr Arg Asn Gly Ser Met Lys Ala Ala Asp 
        195                 200                 205             


Asn Phe Leu Asp Pro Asn Lys Ala Ser Ser Leu Leu Ser Ser Gly Phe 
    210                 215                 220                 


Ser Pro Asp Phe Ala Thr Val Ile Thr Met Asp Arg Lys Ala Ser Lys 
225                 230                 235                 240 


Gln Gln Thr Asn Ile Asp Val Ile Tyr Glu Arg Val Arg Asp Asp Tyr 
                245                 250                 255     


Gln Leu His Trp Thr Ser Thr Asn Trp Lys Gly Thr Asn Thr Lys Asp 
            260                 265                 270         


Lys Trp Thr Asp Arg Ser Ser Glu Arg Tyr Lys Ile Asp Trp Glu Lys 
        275                 280                 285             


Glu Glu Met Thr Asn 
    290             


<210>  5
<211>  184
<212>  PRT
<213>  Mycobacterium smegmatis

<400>  5

Gly Leu Asp Asn Glu Leu Ser Leu Val Asp Gly Gln Asp Arg Thr Leu 
1               5                   10                  15      


Thr Val Gln Gln Trp Asp Thr Phe Leu Asn Gly Val Phe Pro Leu Asp 
            20                  25                  30          


Arg Asn Arg Leu Thr Arg Glu Trp Phe His Ser Gly Arg Ala Lys Tyr 
        35                  40                  45              


Ile Val Ala Gly Pro Gly Ala Asp Glu Phe Glu Gly Thr Leu Glu Leu 
    50                  55                  60                  


Gly Tyr Gln Ile Gly Phe Pro Trp Ser Leu Gly Val Gly Ile Asn Phe 
65                  70                  75                  80  


Ser Tyr Thr Thr Pro Asn Ile Leu Ile Asp Asp Gly Asp Ile Thr Ala 
                85                  90                  95      


Pro Pro Phe Gly Leu Asn Ser Val Ile Thr Pro Asn Leu Phe Pro Gly 
            100                 105                 110         


Val Ser Ile Ser Ala Asp Leu Gly Asn Gly Pro Gly Ile Gln Glu Val 
        115                 120                 125             


Ala Thr Phe Ser Val Asp Val Ser Gly Pro Ala Gly Gly Val Ala Val 
    130                 135                 140                 


Ser Asn Ala His Gly Thr Val Thr Gly Ala Ala Gly Gly Val Leu Leu 
145                 150                 155                 160 


Arg Pro Phe Ala Arg Leu Ile Ala Ser Thr Gly Asp Ser Val Thr Thr 
                165                 170                 175     


Tyr Gly Glu Pro Trp Asn Met Asn 
            180                 


<210>  6
<211>  184
<212>  PRT
<213>  Mycobacterium smegmatis

<400>  6

Gly Leu Asp Asn Glu Leu Ser Leu Val Asp Gly Gln Asp Arg Thr Leu 
1               5                   10                  15      


Thr Val Gln Gln Trp Asp Thr Phe Leu Asn Gly Val Phe Pro Leu Asp 
            20                  25                  30          


Arg Asn Arg Leu Thr Arg Glu Trp Phe His Ser Gly Arg Ala Lys Tyr 
        35                  40                  45              


Ile Val Ala Gly Pro Gly Ala Asp Glu Phe Glu Gly Thr Leu Glu Leu 
    50                  55                  60                  


Gly Tyr Gln Ile Gly Phe Pro Trp Ser Leu Gly Val Gly Ile Asn Phe 
65                  70                  75                  80  


Ser Tyr Thr Thr Pro Asn Ile Leu Ile Asp Asp Gly Asp Ile Thr Gly 
                85                  90                  95      


Pro Pro Phe Gly Leu Glu Ser Val Ile Thr Pro Asn Leu Phe Pro Gly 
            100                 105                 110         


Val Ser Ile Ser Ala Asp Leu Gly Asn Gly Pro Gly Ile Gln Glu Val 
        115                 120                 125             


Ala Thr Phe Ser Val Asp Val Ser Gly Pro Ala Gly Gly Val Ala Val 
    130                 135                 140                 


Ser Asn Ala His Gly Thr Val Thr Gly Ala Ala Gly Gly Val Leu Leu 
145                 150                 155                 160 


Arg Pro Phe Ala Arg Leu Ile Ala Ser Thr Gly Asp Ser Val Thr Thr 
                165                 170                 175     


Tyr Gly Glu Pro Trp Asn Met Asn 
            180                 


<210>  7
<211>  183
<212>  PRT
<213>  Mycobacterium smegmatis

<400>  7

Val Asp Asn Gln Leu Ser Val Val Asp Gly Gln Gly Arg Thr Leu Thr 
1               5                   10                  15      


Val Gln Gln Ala Glu Thr Phe Leu Asn Gly Val Phe Pro Leu Asp Arg 
            20                  25                  30          


Asn Arg Leu Thr Arg Glu Trp Phe His Ser Gly Arg Ala Thr Tyr His 
        35                  40                  45              


Val Ala Gly Pro Gly Ala Asp Glu Phe Glu Gly Thr Leu Glu Leu Gly 
    50                  55                  60                  


Tyr Gln Val Gly Phe Pro Trp Ser Leu Gly Val Gly Ile Asn Phe Ser 
65                  70                  75                  80  


Tyr Thr Thr Pro Asn Ile Leu Ile Asp Gly Gly Asp Ile Thr Gln Pro 
                85                  90                  95      


Pro Phe Gly Leu Asp Thr Ile Ile Thr Pro Asn Leu Phe Pro Gly Val 
            100                 105                 110         


Ser Ile Ser Ala Asp Leu Gly Asn Gly Pro Gly Ile Gln Glu Val Ala 
        115                 120                 125             


Thr Phe Ser Val Asp Val Lys Gly Ala Lys Gly Ala Val Ala Val Ser 
    130                 135                 140                 


Asn Ala His Gly Thr Val Thr Gly Ala Ala Gly Gly Val Leu Leu Arg 
145                 150                 155                 160 


Pro Phe Ala Arg Leu Ile Ala Ser Thr Gly Asp Ser Val Thr Thr Tyr 
                165                 170                 175     


Gly Glu Pro Trp Asn Met Asn 
            180             


<210>  8
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of the Hel308 motif


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = C, M or L

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = any amino acid

<400>  8

Gln Xaa Xaa Gly Arg Ala Gly Arg 
1               5               


<210>  9
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of the extended Hel308 motif


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = C, M or L

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = any amino acid

<400>  9

Gln Xaa Xaa Gly Arg Ala Gly Arg Pro 
1               5                   


<210>  10
<211>  760
<212>  PRT
<213>  Methanococcoides burtonii

<400>  10

Met Met Ile Arg Glu Leu Asp Ile Pro Arg Asp Ile Ile Gly Phe Tyr 
1               5                   10                  15      


Glu Asp Ser Gly Ile Lys Glu Leu Tyr Pro Pro Gln Ala Glu Ala Ile 
            20                  25                  30          


Glu Met Gly Leu Leu Glu Lys Lys Asn Leu Leu Ala Ala Ile Pro Thr 
        35                  40                  45              


Ala Ser Gly Lys Thr Leu Leu Ala Glu Leu Ala Met Ile Lys Ala Ile 
    50                  55                  60                  


Arg Glu Gly Gly Lys Ala Leu Tyr Ile Val Pro Leu Arg Ala Leu Ala 
65                  70                  75                  80  


Ser Glu Lys Phe Glu Arg Phe Lys Glu Leu Ala Pro Phe Gly Ile Lys 
                85                  90                  95      


Val Gly Ile Ser Thr Gly Asp Leu Asp Ser Arg Ala Asp Trp Leu Gly 
            100                 105                 110         


Val Asn Asp Ile Ile Val Ala Thr Ser Glu Lys Thr Asp Ser Leu Leu 
        115                 120                 125             


Arg Asn Gly Thr Ser Trp Met Asp Glu Ile Thr Thr Val Val Val Asp 
    130                 135                 140                 


Glu Ile His Leu Leu Asp Ser Lys Asn Arg Gly Pro Thr Leu Glu Val 
145                 150                 155                 160 


Thr Ile Thr Lys Leu Met Arg Leu Asn Pro Asp Val Gln Val Val Ala 
                165                 170                 175     


Leu Ser Ala Thr Val Gly Asn Ala Arg Glu Met Ala Asp Trp Leu Gly 
            180                 185                 190         


Ala Ala Leu Val Leu Ser Glu Trp Arg Pro Thr Asp Leu His Glu Gly 
        195                 200                 205             


Val Leu Phe Gly Asp Ala Ile Asn Phe Pro Gly Ser Gln Lys Lys Ile 
    210                 215                 220                 


Asp Arg Leu Glu Lys Asp Asp Ala Val Asn Leu Val Leu Asp Thr Ile 
225                 230                 235                 240 


Lys Ala Glu Gly Gln Cys Leu Val Phe Glu Ser Ser Arg Arg Asn Cys 
                245                 250                 255     


Ala Gly Phe Ala Lys Thr Ala Ser Ser Lys Val Ala Lys Ile Leu Asp 
            260                 265                 270         


Asn Asp Ile Met Ile Lys Leu Ala Gly Ile Ala Glu Glu Val Glu Ser 
        275                 280                 285             


Thr Gly Glu Thr Asp Thr Ala Ile Val Leu Ala Asn Cys Ile Arg Lys 
    290                 295                 300                 


Gly Val Ala Phe His His Ala Gly Leu Asn Ser Asn His Arg Lys Leu 
305                 310                 315                 320 


Val Glu Asn Gly Phe Arg Gln Asn Leu Ile Lys Val Ile Ser Ser Thr 
                325                 330                 335     


Pro Thr Leu Ala Ala Gly Leu Asn Leu Pro Ala Arg Arg Val Ile Ile 
            340                 345                 350         


Arg Ser Tyr Arg Arg Phe Asp Ser Asn Phe Gly Met Gln Pro Ile Pro 
        355                 360                 365             


Val Leu Glu Tyr Lys Gln Met Ala Gly Arg Ala Gly Arg Pro His Leu 
    370                 375                 380                 


Asp Pro Tyr Gly Glu Ser Val Leu Leu Ala Lys Thr Tyr Asp Glu Phe 
385                 390                 395                 400 


Ala Gln Leu Met Glu Asn Tyr Val Glu Ala Asp Ala Glu Asp Ile Trp 
                405                 410                 415     


Ser Lys Leu Gly Thr Glu Asn Ala Leu Arg Thr His Val Leu Ser Thr 
            420                 425                 430         


Ile Val Asn Gly Phe Ala Ser Thr Arg Gln Glu Leu Phe Asp Phe Phe 
        435                 440                 445             


Gly Ala Thr Phe Phe Ala Tyr Gln Gln Asp Lys Trp Met Leu Glu Glu 
    450                 455                 460                 


Val Ile Asn Asp Cys Leu Glu Phe Leu Ile Asp Lys Ala Met Val Ser 
465                 470                 475                 480 


Glu Thr Glu Asp Ile Glu Asp Ala Ser Lys Leu Phe Leu Arg Gly Thr 
                485                 490                 495     


Arg Leu Gly Ser Leu Val Ser Met Leu Tyr Ile Asp Pro Leu Ser Gly 
            500                 505                 510         


Ser Lys Ile Val Asp Gly Phe Lys Asp Ile Gly Lys Ser Thr Gly Gly 
        515                 520                 525             


Asn Met Gly Ser Leu Glu Asp Asp Lys Gly Asp Asp Ile Thr Val Thr 
    530                 535                 540                 


Asp Met Thr Leu Leu His Leu Val Cys Ser Thr Pro Asp Met Arg Gln 
545                 550                 555                 560 


Leu Tyr Leu Arg Asn Thr Asp Tyr Thr Ile Val Asn Glu Tyr Ile Val 
                565                 570                 575     


Ala His Ser Asp Glu Phe His Glu Ile Pro Asp Lys Leu Lys Glu Thr 
            580                 585                 590         


Asp Tyr Glu Trp Phe Met Gly Glu Val Lys Thr Ala Met Leu Leu Glu 
        595                 600                 605             


Glu Trp Val Thr Glu Val Ser Ala Glu Asp Ile Thr Arg His Phe Asn 
    610                 615                 620                 


Val Gly Glu Gly Asp Ile His Ala Leu Ala Asp Thr Ser Glu Trp Leu 
625                 630                 635                 640 


Met His Ala Ala Ala Lys Leu Ala Glu Leu Leu Gly Val Glu Tyr Ser 
                645                 650                 655     


Ser His Ala Tyr Ser Leu Glu Lys Arg Ile Arg Tyr Gly Ser Gly Leu 
            660                 665                 670         


Asp Leu Met Glu Leu Val Gly Ile Arg Gly Val Gly Arg Val Arg Ala 
        675                 680                 685             


Arg Lys Leu Tyr Asn Ala Gly Phe Val Ser Val Ala Lys Leu Lys Gly 
    690                 695                 700                 


Ala Asp Ile Ser Val Leu Ser Lys Leu Val Gly Pro Lys Val Ala Tyr 
705                 710                 715                 720 


Asn Ile Leu Ser Gly Ile Gly Val Arg Val Asn Asp Lys His Phe Asn 
                725                 730                 735     


Ser Ala Pro Ile Ser Ser Asn Thr Leu Asp Thr Leu Leu Asp Lys Asn 
            740                 745                 750         


Gln Lys Thr Phe Asn Asp Phe Gln 
        755                 760 


<210>  11
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary Hel308 motif

<400>  11

Gln Met Ala Gly Arg Ala Gly Arg 
1               5               


<210>  12
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary extended Hel308 motif

<400>  12

Gln Met Ala Gly Arg Ala Gly Arg Pro 
1               5                   


<210>  13
<211>  707
<212>  PRT
<213>  Cenarchaeum symbiosum

<400>  13

Met Arg Ile Ser Glu Leu Asp Ile Pro Arg Pro Ala Ile Glu Phe Leu 
1               5                   10                  15      


Glu Gly Glu Gly Tyr Lys Lys Leu Tyr Pro Pro Gln Ala Ala Ala Ala 
            20                  25                  30          


Lys Ala Gly Leu Thr Asp Gly Lys Ser Val Leu Val Ser Ala Pro Thr 
        35                  40                  45              


Ala Ser Gly Lys Thr Leu Ile Ala Ala Ile Ala Met Ile Ser His Leu 
    50                  55                  60                  


Ser Arg Asn Arg Gly Lys Ala Val Tyr Leu Ser Pro Leu Arg Ala Leu 
65                  70                  75                  80  


Ala Ala Glu Lys Phe Ala Glu Phe Gly Lys Ile Gly Gly Ile Pro Leu 
                85                  90                  95      


Gly Arg Pro Val Arg Val Gly Val Ser Thr Gly Asp Phe Glu Lys Ala 
            100                 105                 110         


Gly Arg Ser Leu Gly Asn Asn Asp Ile Leu Val Leu Thr Asn Glu Arg 
        115                 120                 125             


Met Asp Ser Leu Ile Arg Arg Arg Pro Asp Trp Met Asp Glu Val Gly 
    130                 135                 140                 


Leu Val Ile Ala Asp Glu Ile His Leu Ile Gly Asp Arg Ser Arg Gly 
145                 150                 155                 160 


Pro Thr Leu Glu Met Val Leu Thr Lys Leu Arg Gly Leu Arg Ser Ser 
                165                 170                 175     


Pro Gln Val Val Ala Leu Ser Ala Thr Ile Ser Asn Ala Asp Glu Ile 
            180                 185                 190         


Ala Gly Trp Leu Asp Cys Thr Leu Val His Ser Thr Trp Arg Pro Val 
        195                 200                 205             


Pro Leu Ser Glu Gly Val Tyr Gln Asp Gly Glu Val Ala Met Gly Asp 
    210                 215                 220                 


Gly Ser Arg His Glu Val Ala Ala Thr Gly Gly Gly Pro Ala Val Asp 
225                 230                 235                 240 


Leu Ala Ala Glu Ser Val Ala Glu Gly Gly Gln Ser Leu Ile Phe Ala 
                245                 250                 255     


Asp Thr Arg Ala Arg Ser Ala Ser Leu Ala Ala Lys Ala Ser Ala Val 
            260                 265                 270         


Ile Pro Glu Ala Lys Gly Ala Asp Ala Ala Lys Leu Ala Ala Ala Ala 
        275                 280                 285             


Lys Lys Ile Ile Ser Ser Gly Gly Glu Thr Lys Leu Ala Lys Thr Leu 
    290                 295                 300                 


Ala Glu Leu Val Glu Lys Gly Ala Ala Phe His His Ala Gly Leu Asn 
305                 310                 315                 320 


Gln Asp Cys Arg Ser Val Val Glu Glu Glu Phe Arg Ser Gly Arg Ile 
                325                 330                 335     


Arg Leu Leu Ala Ser Thr Pro Thr Leu Ala Ala Gly Val Asn Leu Pro 
            340                 345                 350         


Ala Arg Arg Val Val Ile Ser Ser Val Met Arg Tyr Asn Ser Ser Ser 
        355                 360                 365             


Gly Met Ser Glu Pro Ile Ser Ile Leu Glu Tyr Lys Gln Leu Cys Gly 
    370                 375                 380                 


Arg Ala Gly Arg Pro Gln Tyr Asp Lys Ser Gly Glu Ala Ile Val Val 
385                 390                 395                 400 


Gly Gly Val Asn Ala Asp Glu Ile Phe Asp Arg Tyr Ile Gly Gly Glu 
                405                 410                 415     


Pro Glu Pro Ile Arg Ser Ala Met Val Asp Asp Arg Ala Leu Arg Ile 
            420                 425                 430         


His Val Leu Ser Leu Val Thr Thr Ser Pro Gly Ile Lys Glu Asp Asp 
        435                 440                 445             


Val Thr Glu Phe Phe Leu Gly Thr Leu Gly Gly Gln Gln Ser Gly Glu 
    450                 455                 460                 


Ser Thr Val Lys Phe Ser Val Ala Val Ala Leu Arg Phe Leu Gln Glu 
465                 470                 475                 480 


Glu Gly Met Leu Gly Arg Arg Gly Gly Arg Leu Ala Ala Thr Lys Met 
                485                 490                 495     


Gly Arg Leu Val Ser Arg Leu Tyr Met Asp Pro Met Thr Ala Val Thr 
            500                 505                 510         


Leu Arg Asp Ala Val Gly Glu Ala Ser Pro Gly Arg Met His Thr Leu 
        515                 520                 525             


Gly Phe Leu His Leu Val Ser Glu Cys Ser Glu Phe Met Pro Arg Phe 
    530                 535                 540                 


Ala Leu Arg Gln Lys Asp His Glu Val Ala Glu Met Met Leu Glu Ala 
545                 550                 555                 560 


Gly Arg Gly Glu Leu Leu Arg Pro Val Tyr Ser Tyr Glu Cys Gly Arg 
                565                 570                 575     


Gly Leu Leu Ala Leu His Arg Trp Ile Gly Glu Ser Pro Glu Ala Lys 
            580                 585                 590         


Leu Ala Glu Asp Leu Lys Phe Glu Ser Gly Asp Val His Arg Met Val 
        595                 600                 605             


Glu Ser Ser Gly Trp Leu Leu Arg Cys Ile Trp Glu Ile Ser Lys His 
    610                 615                 620                 


Gln Glu Arg Pro Asp Leu Leu Gly Glu Leu Asp Val Leu Arg Ser Arg 
625                 630                 635                 640 


Val Ala Tyr Gly Ile Lys Ala Glu Leu Val Pro Leu Val Ser Ile Lys 
                645                 650                 655     


Gly Ile Gly Arg Val Arg Ser Arg Arg Leu Phe Arg Gly Gly Ile Lys 
            660                 665                 670         


Gly Pro Gly Asp Leu Ala Ala Val Pro Val Glu Arg Leu Ser Arg Val 
        675                 680                 685             


Glu Gly Ile Gly Ala Thr Leu Ala Asn Asn Ile Lys Ser Gln Leu Arg 
    690                 695                 700                 


Lys Gly Gly 
705         


<210>  14
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary Hel308 motif

<400>  14

Gln Leu Cys Gly Arg Ala Gly Arg 
1               5               


<210>  15
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary extended Hel308 motif

<400>  15

Gln Leu Cys Gly Arg Ala Gly Arg Pro 
1               5                   


<210>  16
<211>  720
<212>  PRT
<213>  Thermococcus gammatolerans

<400>  16

Met Lys Val Asp Glu Leu Pro Val Asp Glu Arg Leu Lys Ala Val Leu 
1               5                   10                  15      


Lys Glu Arg Gly Ile Glu Glu Leu Tyr Pro Pro Gln Ala Glu Ala Leu 
            20                  25                  30          


Lys Ser Gly Ala Leu Glu Gly Arg Asn Leu Val Leu Ala Ile Pro Thr 
        35                  40                  45              


Ala Ser Gly Lys Thr Leu Val Ser Glu Ile Val Met Val Asn Lys Leu 
    50                  55                  60                  


Ile Gln Glu Gly Gly Lys Ala Val Tyr Leu Val Pro Leu Lys Ala Leu 
65                  70                  75                  80  


Ala Glu Glu Lys Tyr Arg Glu Phe Lys Glu Trp Glu Lys Leu Gly Leu 
                85                  90                  95      


Lys Val Ala Ala Thr Thr Gly Asp Tyr Asp Ser Thr Asp Asp Trp Leu 
            100                 105                 110         


Gly Arg Tyr Asp Ile Ile Val Ala Thr Ala Glu Lys Phe Asp Ser Leu 
        115                 120                 125             


Leu Arg His Gly Ala Arg Trp Ile Asn Asp Val Lys Leu Val Val Ala 
    130                 135                 140                 


Asp Glu Val His Leu Ile Gly Ser Tyr Asp Arg Gly Ala Thr Leu Glu 
145                 150                 155                 160 


Met Ile Leu Thr His Met Leu Gly Arg Ala Gln Ile Leu Ala Leu Ser 
                165                 170                 175     


Ala Thr Val Gly Asn Ala Glu Glu Leu Ala Glu Trp Leu Asp Ala Ser 
            180                 185                 190         


Leu Val Val Ser Asp Trp Arg Pro Val Gln Leu Arg Arg Gly Val Phe 
        195                 200                 205             


His Leu Gly Thr Leu Ile Trp Glu Asp Gly Lys Val Glu Ser Tyr Pro 
    210                 215                 220                 


Glu Asn Trp Tyr Ser Leu Val Val Asp Ala Val Lys Arg Gly Lys Gly 
225                 230                 235                 240 


Ala Leu Val Phe Val Asn Thr Arg Arg Ser Ala Glu Lys Glu Ala Leu 
                245                 250                 255     


Ala Leu Ser Lys Leu Val Ser Ser His Leu Thr Lys Pro Glu Lys Arg 
            260                 265                 270         


Ala Leu Glu Ser Leu Ala Ser Gln Leu Glu Asp Asn Pro Thr Ser Glu 
        275                 280                 285             


Lys Leu Lys Arg Ala Leu Arg Gly Gly Val Ala Phe His His Ala Gly 
    290                 295                 300                 


Leu Ser Arg Val Glu Arg Thr Leu Ile Glu Asp Ala Phe Arg Glu Gly 
305                 310                 315                 320 


Leu Ile Lys Val Ile Thr Ala Thr Pro Thr Leu Ser Ala Gly Val Asn 
                325                 330                 335     


Leu Pro Ser Phe Arg Val Ile Ile Arg Asp Thr Lys Arg Tyr Ala Gly 
            340                 345                 350         


Phe Gly Trp Thr Asp Ile Pro Val Leu Glu Ile Gln Gln Met Met Gly 
        355                 360                 365             


Arg Ala Gly Arg Pro Arg Tyr Asp Lys Tyr Gly Glu Ala Ile Ile Val 
    370                 375                 380                 


Ala Arg Thr Asp Glu Pro Gly Lys Leu Met Glu Arg Tyr Ile Arg Gly 
385                 390                 395                 400 


Lys Pro Glu Lys Leu Phe Ser Met Leu Ala Asn Glu Gln Ala Phe Arg 
                405                 410                 415     


Ser Gln Val Leu Ala Leu Ile Thr Asn Phe Gly Ile Arg Ser Phe Pro 
            420                 425                 430         


Glu Leu Val Arg Phe Leu Glu Arg Thr Phe Tyr Ala His Gln Arg Lys 
        435                 440                 445             


Asp Leu Ser Ser Leu Glu Tyr Lys Ala Lys Glu Val Val Tyr Phe Leu 
    450                 455                 460                 


Ile Glu Asn Glu Phe Ile Asp Leu Asp Leu Glu Asp Arg Phe Ile Pro 
465                 470                 475                 480 


Leu Pro Phe Gly Lys Arg Thr Ser Gln Leu Tyr Ile Asp Pro Leu Thr 
                485                 490                 495     


Ala Lys Lys Phe Lys Asp Ala Phe Pro Ala Ile Glu Arg Asn Pro Asn 
            500                 505                 510         


Pro Phe Gly Ile Phe Gln Leu Ile Ala Ser Thr Pro Asp Met Ala Thr 
        515                 520                 525             


Leu Thr Ala Arg Arg Arg Glu Met Glu Asp Tyr Leu Asp Leu Ala Tyr 
    530                 535                 540                 


Glu Leu Glu Asp Lys Leu Tyr Ala Ser Ile Pro Tyr Tyr Glu Asp Ser 
545                 550                 555                 560 


Arg Phe Gln Gly Phe Leu Gly Gln Val Lys Thr Ala Lys Val Leu Leu 
                565                 570                 575     


Asp Trp Ile Asn Glu Val Pro Glu Ala Arg Ile Tyr Glu Thr Tyr Ser 
            580                 585                 590         


Ile Asp Pro Gly Asp Leu Tyr Arg Leu Leu Glu Leu Ala Asp Trp Leu 
        595                 600                 605             


Met Tyr Ser Leu Ile Glu Leu Tyr Lys Leu Phe Glu Pro Lys Glu Glu 
    610                 615                 620                 


Ile Leu Asn Tyr Leu Arg Asp Leu His Leu Arg Leu Arg His Gly Val 
625                 630                 635                 640 


Arg Glu Glu Leu Leu Glu Leu Val Arg Leu Pro Asn Ile Gly Arg Lys 
                645                 650                 655     


Arg Ala Arg Ala Leu Tyr Asn Ala Gly Phe Arg Ser Val Glu Ala Ile 
            660                 665                 670         


Ala Asn Ala Lys Pro Ala Glu Leu Leu Ala Val Glu Gly Ile Gly Ala 
        675                 680                 685             


Lys Ile Leu Asp Gly Ile Tyr Arg His Leu Gly Ile Glu Lys Arg Val 
    690                 695                 700                 


Thr Glu Glu Lys Pro Lys Arg Lys Gly Thr Leu Glu Asp Phe Leu Arg 
705                 710                 715                 720 


<210>  17
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary extended Hel308 motif

<400>  17

Gln Met Met Gly Arg Ala Gly Arg 
1               5               


<210>  18
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary extended Hel308 motif

<400>  18

Gln Met Met Gly Arg Ala Gly Arg Pro 
1               5                   


<210>  19
<211>  799
<212>  PRT
<213>  Methanospirillum hungatei

<400>  19

Met Glu Ile Ala Ser Leu Pro Leu Pro Asp Ser Phe Ile Arg Ala Cys 
1               5                   10                  15      


His Ala Lys Gly Ile Arg Ser Leu Tyr Pro Pro Gln Ala Glu Cys Ile 
            20                  25                  30          


Glu Lys Gly Leu Leu Glu Gly Lys Asn Leu Leu Ile Ser Ile Pro Thr 
        35                  40                  45              


Ala Ser Gly Lys Thr Leu Leu Ala Glu Met Ala Met Trp Ser Arg Ile 
    50                  55                  60                  


Ala Ala Gly Gly Lys Cys Leu Tyr Ile Val Pro Leu Arg Ala Leu Ala 
65                  70                  75                  80  


Ser Glu Lys Tyr Asp Glu Phe Ser Lys Lys Gly Val Ile Arg Val Gly 
                85                  90                  95      


Ile Ala Thr Gly Asp Leu Asp Arg Thr Asp Ala Tyr Leu Gly Glu Asn 
            100                 105                 110         


Asp Ile Ile Val Ala Thr Ser Glu Lys Thr Asp Ser Leu Leu Arg Asn 
        115                 120                 125             


Arg Thr Pro Trp Leu Ser Gln Ile Thr Cys Ile Val Leu Asp Glu Val 
    130                 135                 140                 


His Leu Ile Gly Ser Glu Asn Arg Gly Ala Thr Leu Glu Met Val Ile 
145                 150                 155                 160 


Thr Lys Leu Arg Tyr Thr Asn Pro Val Met Gln Ile Ile Gly Leu Ser 
                165                 170                 175     


Ala Thr Ile Gly Asn Pro Ala Gln Leu Ala Glu Trp Leu Asp Ala Thr 
            180                 185                 190         


Leu Ile Thr Ser Thr Trp Arg Pro Val Asp Leu Arg Gln Gly Val Tyr 
        195                 200                 205             


Tyr Asn Gly Lys Ile Arg Phe Ser Asp Ser Glu Arg Pro Ile Gln Gly 
    210                 215                 220                 


Lys Thr Lys His Asp Asp Leu Asn Leu Cys Leu Asp Thr Ile Glu Glu 
225                 230                 235                 240 


Gly Gly Gln Cys Leu Val Phe Val Ser Ser Arg Arg Asn Ala Glu Gly 
                245                 250                 255     


Phe Ala Lys Lys Ala Ala Gly Ala Leu Lys Ala Gly Ser Pro Asp Ser 
            260                 265                 270         


Lys Ala Leu Ala Gln Glu Leu Arg Arg Leu Arg Asp Arg Asp Glu Gly 
        275                 280                 285             


Asn Val Leu Ala Asp Cys Val Glu Arg Gly Ala Ala Phe His His Ala 
    290                 295                 300                 


Gly Leu Ile Arg Gln Glu Arg Thr Ile Ile Glu Glu Gly Phe Arg Asn 
305                 310                 315                 320 


Gly Tyr Ile Glu Val Ile Ala Ala Thr Pro Thr Leu Ala Ala Gly Leu 
                325                 330                 335     


Asn Leu Pro Ala Arg Arg Val Ile Ile Arg Asp Tyr Asn Arg Phe Ala 
            340                 345                 350         


Ser Gly Leu Gly Met Val Pro Ile Pro Val Gly Glu Tyr His Gln Met 
        355                 360                 365             


Ala Gly Arg Ala Gly Arg Pro His Leu Asp Pro Tyr Gly Glu Ala Val 
    370                 375                 380                 


Leu Leu Ala Lys Asp Ala Pro Ser Val Glu Arg Leu Phe Glu Thr Phe 
385                 390                 395                 400 


Ile Asp Ala Glu Ala Glu Arg Val Asp Ser Gln Cys Val Asp Asp Ala 
                405                 410                 415     


Ser Leu Cys Ala His Ile Leu Ser Leu Ile Ala Thr Gly Phe Ala His 
            420                 425                 430         


Asp Gln Glu Ala Leu Ser Ser Phe Met Glu Arg Thr Phe Tyr Phe Phe 
        435                 440                 445             


Gln His Pro Lys Thr Arg Ser Leu Pro Arg Leu Val Ala Asp Ala Ile 
    450                 455                 460                 


Arg Phe Leu Thr Thr Ala Gly Met Val Glu Glu Arg Glu Asn Thr Leu 
465                 470                 475                 480 


Ser Ala Thr Arg Leu Gly Ser Leu Val Ser Arg Leu Tyr Leu Asn Pro 
                485                 490                 495     


Cys Thr Ala Arg Leu Ile Leu Asp Ser Leu Lys Ser Cys Lys Thr Pro 
            500                 505                 510         


Thr Leu Ile Gly Leu Leu His Val Ile Cys Val Ser Pro Asp Met Gln 
        515                 520                 525             


Arg Leu Tyr Leu Lys Ala Ala Asp Thr Gln Leu Leu Arg Thr Phe Leu 
    530                 535                 540                 


Phe Lys His Lys Asp Asp Leu Ile Leu Pro Leu Pro Phe Glu Gln Glu 
545                 550                 555                 560 


Glu Glu Glu Leu Trp Leu Ser Gly Leu Lys Thr Ala Leu Val Leu Thr 
                565                 570                 575     


Asp Trp Ala Asp Glu Phe Ser Glu Gly Met Ile Glu Glu Arg Tyr Gly 
            580                 585                 590         


Ile Gly Ala Gly Asp Leu Tyr Asn Ile Val Asp Ser Gly Lys Trp Leu 
        595                 600                 605             


Leu His Gly Thr Glu Arg Leu Val Ser Val Glu Met Pro Glu Met Ser 
    610                 615                 620                 


Gln Val Val Lys Thr Leu Ser Val Arg Val His His Gly Val Lys Ser 
625                 630                 635                 640 


Glu Leu Leu Pro Leu Val Ala Leu Arg Asn Ile Gly Arg Val Arg Ala 
                645                 650                 655     


Arg Thr Leu Tyr Asn Ala Gly Tyr Pro Asp Pro Glu Ala Val Ala Arg 
            660                 665                 670         


Ala Gly Leu Ser Thr Ile Ala Arg Ile Ile Gly Glu Gly Ile Ala Arg 
        675                 680                 685             


Gln Val Ile Asp Glu Ile Thr Gly Val Lys Arg Ser Gly Ile His Ser 
    690                 695                 700                 


Ser Asp Asp Asp Tyr Gln Gln Lys Thr Pro Glu Leu Leu Thr Asp Ile 
705                 710                 715                 720 


Pro Gly Ile Gly Lys Lys Met Ala Glu Lys Leu Gln Asn Ala Gly Ile 
                725                 730                 735     


Ile Thr Val Ser Asp Leu Leu Thr Ala Asp Glu Val Leu Leu Ser Asp 
            740                 745                 750         


Val Leu Gly Ala Ala Arg Ala Arg Lys Val Leu Ala Phe Leu Ser Asn 
        755                 760                 765             


Ser Glu Lys Glu Asn Ser Ser Ser Asp Lys Thr Glu Glu Ile Pro Asp 
    770                 775                 780                 


Thr Gln Lys Ile Arg Gly Gln Ser Ser Trp Glu Asp Phe Gly Cys 
785                 790                 795                 


<210>  20
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RecD-like motif I


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = G, S or A

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = P, A, S or G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = T, A, V, S or C

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa = G or A

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa = T or S

<400>  20

Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa 
1               5               


<210>  21
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Extended RecD-like motif I


<220>
<221>  MISC_FEATURE
<222>  (2)..(17)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa = G, S or A

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa = P, A, S or G

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa = T, A, V, S or C

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa = G or A

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa = K or R

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = T or S

<400>  21

Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa 
            20                  25  


<210>  22
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Extended RecD-like motif I


<220>
<221>  MISC_FEATURE
<222>  (2)..(18)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa = G, S or A

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa = P, A, S or G

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa = T, A, V, S or C

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa = G or A

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = K or A

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa = T or S

<400>  22

Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa 
            20                  25      


<210>  23
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Extended RecD-like motif I


<220>
<221>  MISC_FEATURE
<222>  (2)..(19)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa = G, S or A

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa = P, A, S or G

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa = T, A, V, S or C

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = G or A

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa = K or R

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa = T or S

<400>  23

Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa 
            20                  25          


<210>  24
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RecD motif I


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = T, V or C

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa = T or S

<400>  24

Gly Gly Pro Gly Xaa Gly Lys Xaa 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Preferred RecD motif I

<400>  25

Gly Gly Pro Gly Thr Gly Lys Thr 
1               5               


<210>  26
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Extended RecD motif I


<220>
<221>  MISC_FEATURE
<222>  (2)..(17)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa = T, V or C

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = T or S

<400>  26

Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Gly Gly Pro Gly Xaa Gly Lys Xaa 
            20                  25  


<210>  27
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Extended RecD motif I


<220>
<221>  MISC_FEATURE
<222>  (2)..(18)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa = T, V or C

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa = T or S

<400>  27

Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Gly Gly Pro Gly Xaa Gly Lys Xaa 
            20                  25      


<210>  28
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Extended RecD motif I


<220>
<221>  MISC_FEATURE
<222>  (2)..(19)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa = T, V or C

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa = T or S

<400>  28

Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Gly Gly Pro Gly Xaa Gly Lys Xaa 
            20                  25          


<210>  29
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RecD-like motif V


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = Y, W or F

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = A, T, S, M, C or V

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = T, N or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = A, T, G, S, V or I

<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa = G or S

<400>  29

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Xaa 
1               5                   10  


<210>  30
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RecD motif V


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = Y, W or F

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = A, M, C or V

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = I, M or L

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = T or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = V or I

<400>  30

Xaa Xaa Xaa Xaa Xaa His Lys Ser Gln Gly 
1               5                   10  


<210>  31
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobF motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = any amino acid except D, E, R and K

<220>
<221>  MISC_FEATURE
<222>  (6)..(10)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa = any amino acid except D, E, R and K

<400>  31

His Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa His Xaa His 
1               5                   10              


<210>  32
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobF motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = any amino acid except D, E, R and K

<220>
<221>  MISC_FEATURE
<222>  (6)..(11)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = any amino acid except D, E, R and K

<400>  32

His Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa His Xaa His 
1               5                   10                  


<210>  33
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobF motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = any amino acid except D, E, R and K

<220>
<221>  MISC_FEATURE
<222>  (6)..(12)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = any amino acid except D, E, R and K

<400>  33

His Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa His 
1               5                   10                  15  


<210>  34
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobF motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = any amino acid except D, E, R and K

<220>
<221>  MISC_FEATURE
<222>  (6)..(13)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa = any amino acid except D, E, R and K

<400>  34

His Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa His 
1               5                   10                  15      


<210>  35
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobF motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = any amino acid except D, E, R and K

<220>
<221>  MISC_FEATURE
<222>  (6)..(14)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa = any amino acid except D, E, R and K

<400>  35

His Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa 
1               5                   10                  15      


His 
    


<210>  36
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobF motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = any amino acid except D, E, R and K

<220>
<221>  MISC_FEATURE
<222>  (6)..(15)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = any amino acid except D, E, R and K

<400>  36

His Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa His 
1               5                   10                  15      


Xaa His 
        


<210>  37
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobF motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = any amino acid except D, E, R and K

<220>
<221>  MISC_FEATURE
<222>  (6)..(16)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa = any amino acid except D, E, R and K

<400>  37

His Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


His Xaa His 
            


<210>  38
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobF motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = any amino acid except D, E, R and K

<220>
<221>  MISC_FEATURE
<222>  (6)..(17)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa = any amino acid

<400>  38

His Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa His Xaa His 
            20  


<210>  39
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobQ motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = D or E

<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (10)..(15)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = any amino acid except D, E, K and R

<400>  39

Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa Xaa Xaa Xaa Xaa Xaa His 
1               5                   10                  15      


Xaa 
    


<210>  40
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobQ motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = D or E

<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (10)..(16)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa = any amino acid except D, E, K and R

<400>  40

Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


His Xaa 
        


<210>  41
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobQ motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = D or E

<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (10)..(17)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa = any amino acid except D, E, K and R

<400>  41

Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa His Xaa 
            


<210>  42
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobQ motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = D or E

<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (10)..(18)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa = any amino acid except D, E, K and R

<400>  42

Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Xaa 
            20  


<210>  43
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobQ motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = D or E

<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (10)..(19)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa = any amino acid

<400>  43

Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa His Xaa 
            20      


<210>  44
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobQ motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = D or E

<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (10)..(20)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa = any amino acid except D, E, K and R

<400>  44

Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa His Xaa 
            20          


<210>  45
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobQ motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = D or E

<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (10)..(21)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa = any amino acid except D, E, K and R

<400>  45

Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa His Xaa 
            20              


<210>  46
<211>  1756
<212>  PRT
<213>  Escherichia coli

<400>  46

Met Met Ser Ile Ala Gln Val Arg Ser Ala Gly Ser Ala Gly Asn Tyr 
1               5                   10                  15      


Tyr Thr Asp Lys Asp Asn Tyr Tyr Val Leu Gly Ser Met Gly Glu Arg 
            20                  25                  30          


Trp Ala Gly Lys Gly Ala Glu Gln Leu Gly Leu Gln Gly Ser Val Asp 
        35                  40                  45              


Lys Asp Val Phe Thr Arg Leu Leu Glu Gly Arg Leu Pro Asp Gly Ala 
    50                  55                  60                  


Asp Leu Ser Arg Met Gln Asp Gly Ser Asn Lys His Arg Pro Gly Tyr 
65                  70                  75                  80  


Asp Leu Thr Phe Ser Ala Pro Lys Ser Val Ser Met Met Ala Met Leu 
                85                  90                  95      


Gly Gly Asp Lys Arg Leu Ile Asp Ala His Asn Gln Ala Val Asp Phe 
            100                 105                 110         


Ala Val Arg Gln Val Glu Ala Leu Ala Ser Thr Arg Val Met Thr Asp 
        115                 120                 125             


Gly Gln Ser Glu Thr Val Leu Thr Gly Asn Leu Val Met Ala Leu Phe 
    130                 135                 140                 


Asn His Asp Thr Ser Arg Asp Gln Glu Pro Gln Leu His Thr His Ala 
145                 150                 155                 160 


Val Val Ala Asn Val Thr Gln His Asn Gly Glu Trp Lys Thr Leu Ser 
                165                 170                 175     


Ser Asp Lys Val Gly Lys Thr Gly Phe Ile Glu Asn Val Tyr Ala Asn 
            180                 185                 190         


Gln Ile Ala Phe Gly Arg Leu Tyr Arg Glu Lys Leu Lys Glu Gln Val 
        195                 200                 205             


Glu Ala Leu Gly Tyr Glu Thr Glu Val Val Gly Lys His Gly Met Trp 
    210                 215                 220                 


Glu Met Pro Gly Val Pro Val Glu Ala Phe Ser Gly Arg Ser Gln Ala 
225                 230                 235                 240 


Ile Arg Glu Ala Val Gly Glu Asp Ala Ser Leu Lys Ser Arg Asp Val 
                245                 250                 255     


Ala Ala Leu Asp Thr Arg Lys Ser Lys Gln His Val Asp Pro Glu Ile 
            260                 265                 270         


Arg Met Ala Glu Trp Met Gln Thr Leu Lys Glu Thr Gly Phe Asp Ile 
        275                 280                 285             


Arg Ala Tyr Arg Asp Ala Ala Asp Gln Arg Thr Glu Ile Arg Thr Gln 
    290                 295                 300                 


Ala Pro Gly Pro Ala Ser Gln Asp Gly Pro Asp Val Gln Gln Ala Val 
305                 310                 315                 320 


Thr Gln Ala Ile Ala Gly Leu Ser Glu Arg Lys Val Gln Phe Thr Tyr 
                325                 330                 335     


Thr Asp Val Leu Ala Arg Thr Val Gly Ile Leu Pro Pro Glu Asn Gly 
            340                 345                 350         


Val Ile Glu Arg Ala Arg Ala Gly Ile Asp Glu Ala Ile Ser Arg Glu 
        355                 360                 365             


Gln Leu Ile Pro Leu Asp Arg Glu Lys Gly Leu Phe Thr Ser Gly Ile 
    370                 375                 380                 


His Val Leu Asp Glu Leu Ser Val Arg Ala Leu Ser Arg Asp Ile Met 
385                 390                 395                 400 


Lys Gln Asn Arg Val Thr Val His Pro Glu Lys Ser Val Pro Arg Thr 
                405                 410                 415     


Ala Gly Tyr Ser Asp Ala Val Ser Val Leu Ala Gln Asp Arg Pro Ser 
            420                 425                 430         


Leu Ala Ile Val Ser Gly Gln Gly Gly Ala Ala Gly Gln Arg Glu Arg 
        435                 440                 445             


Val Ala Glu Leu Val Met Met Ala Arg Glu Gln Gly Arg Glu Val Gln 
    450                 455                 460                 


Ile Ile Ala Ala Asp Arg Arg Ser Gln Met Asn Leu Lys Gln Asp Glu 
465                 470                 475                 480 


Arg Leu Ser Gly Glu Leu Ile Thr Gly Arg Arg Gln Leu Leu Glu Gly 
                485                 490                 495     


Met Ala Phe Thr Pro Gly Ser Thr Val Ile Val Asp Gln Gly Glu Lys 
            500                 505                 510         


Leu Ser Leu Lys Glu Thr Leu Thr Leu Leu Asp Gly Ala Ala Arg His 
        515                 520                 525             


Asn Val Gln Val Leu Ile Thr Asp Ser Gly Gln Arg Thr Gly Thr Gly 
    530                 535                 540                 


Ser Ala Leu Met Ala Met Lys Asp Ala Gly Val Asn Thr Tyr Arg Trp 
545                 550                 555                 560 


Gln Gly Gly Glu Gln Arg Pro Ala Thr Ile Ile Ser Glu Pro Asp Arg 
                565                 570                 575     


Asn Val Arg Tyr Ala Arg Leu Ala Gly Asp Phe Ala Ala Ser Val Lys 
            580                 585                 590         


Ala Gly Glu Glu Ser Val Ala Gln Val Ser Gly Val Arg Glu Gln Ala 
        595                 600                 605             


Ile Leu Thr Gln Ala Ile Arg Ser Glu Leu Lys Thr Gln Gly Val Leu 
    610                 615                 620                 


Gly His Pro Glu Val Thr Met Thr Ala Leu Ser Pro Val Trp Leu Asp 
625                 630                 635                 640 


Ser Arg Ser Arg Tyr Leu Arg Asp Met Tyr Arg Pro Gly Met Val Met 
                645                 650                 655     


Glu Gln Trp Asn Pro Glu Thr Arg Ser His Asp Arg Tyr Val Ile Asp 
            660                 665                 670         


Arg Val Thr Ala Gln Ser His Ser Leu Thr Leu Arg Asp Ala Gln Gly 
        675                 680                 685             


Glu Thr Gln Val Val Arg Ile Ser Ser Leu Asp Ser Ser Trp Ser Leu 
    690                 695                 700                 


Phe Arg Pro Glu Lys Met Pro Val Ala Asp Gly Glu Arg Leu Arg Val 
705                 710                 715                 720 


Thr Gly Lys Ile Pro Gly Leu Arg Val Ser Gly Gly Asp Arg Leu Gln 
                725                 730                 735     


Val Ala Ser Val Ser Glu Asp Ala Met Thr Val Val Val Pro Gly Arg 
            740                 745                 750         


Ala Glu Pro Ala Ser Leu Pro Val Ser Asp Ser Pro Phe Thr Ala Leu 
        755                 760                 765             


Lys Leu Glu Asn Gly Trp Val Glu Thr Pro Gly His Ser Val Ser Asp 
    770                 775                 780                 


Ser Ala Thr Val Phe Ala Ser Val Thr Gln Met Ala Met Asp Asn Ala 
785                 790                 795                 800 


Thr Leu Asn Gly Leu Ala Arg Ser Gly Arg Asp Val Arg Leu Tyr Ser 
                805                 810                 815     


Ser Leu Asp Glu Thr Arg Thr Ala Glu Lys Leu Ala Arg His Pro Ser 
            820                 825                 830         


Phe Thr Val Val Ser Glu Gln Ile Lys Ala Arg Ala Gly Glu Thr Leu 
        835                 840                 845             


Leu Glu Thr Ala Ile Ser Leu Gln Lys Ala Gly Leu His Thr Pro Ala 
    850                 855                 860                 


Gln Gln Ala Ile His Leu Ala Leu Pro Val Leu Glu Ser Lys Asn Leu 
865                 870                 875                 880 


Ala Phe Ser Met Val Asp Leu Leu Thr Glu Ala Lys Ser Phe Ala Ala 
                885                 890                 895     


Glu Gly Thr Gly Phe Thr Glu Leu Gly Gly Glu Ile Asn Ala Gln Ile 
            900                 905                 910         


Lys Arg Gly Asp Leu Leu Tyr Val Asp Val Ala Lys Gly Tyr Gly Thr 
        915                 920                 925             


Gly Leu Leu Val Ser Arg Ala Ser Tyr Glu Ala Glu Lys Ser Ile Leu 
    930                 935                 940                 


Arg His Ile Leu Glu Gly Lys Glu Ala Val Thr Pro Leu Met Glu Arg 
945                 950                 955                 960 


Val Pro Gly Glu Leu Met Glu Thr Leu Thr Ser Gly Gln Arg Ala Ala 
                965                 970                 975     


Thr Arg Met Ile Leu Glu Thr Ser Asp Arg Phe Thr Val Val Gln Gly 
            980                 985                 990         


Tyr Ala Gly Val Gly Lys Thr Thr  Gln Phe Arg Ala Val  Met Ser Ala 
        995                 1000                 1005             


Val Asn  Met Leu Pro Ala Ser  Glu Arg Pro Arg Val  Val Gly Leu 
    1010                 1015                 1020             


Gly Pro  Thr His Arg Ala Val  Gly Glu Met Arg Ser  Ala Gly Val 
    1025                 1030                 1035             


Asp Ala  Gln Thr Leu Ala Ser  Phe Leu His Asp Thr  Gln Leu Gln 
    1040                 1045                 1050             


Gln Arg  Ser Gly Glu Thr Pro  Asp Phe Ser Asn Thr  Leu Phe Leu 
    1055                 1060                 1065             


Leu Asp  Glu Ser Ser Met Val  Gly Asn Thr Glu Met  Ala Arg Ala 
    1070                 1075                 1080             


Tyr Ala  Leu Ile Ala Ala Gly  Gly Gly Arg Ala Val  Ala Ser Gly 
    1085                 1090                 1095             


Asp Thr  Asp Gln Leu Gln Ala  Ile Ala Pro Gly Gln  Ser Phe Arg 
    1100                 1105                 1110             


Leu Gln  Gln Thr Arg Ser Ala  Ala Asp Val Val Ile  Met Lys Glu 
    1115                 1120                 1125             


Ile Val  Arg Gln Thr Pro Glu  Leu Arg Glu Ala Val  Tyr Ser Leu 
    1130                 1135                 1140             


Ile Asn  Arg Asp Val Glu Arg  Ala Leu Ser Gly Leu  Glu Ser Val 
    1145                 1150                 1155             


Lys Pro  Ser Gln Val Pro Arg  Leu Glu Gly Ala Trp  Ala Pro Glu 
    1160                 1165                 1170             


His Ser  Val Thr Glu Phe Ser  His Ser Gln Glu Ala  Lys Leu Ala 
    1175                 1180                 1185             


Glu Ala  Gln Gln Lys Ala Met  Leu Lys Gly Glu Ala  Phe Pro Asp 
    1190                 1195                 1200             


Ile Pro  Met Thr Leu Tyr Glu  Ala Ile Val Arg Asp  Tyr Thr Gly 
    1205                 1210                 1215             


Arg Thr  Pro Glu Ala Arg Glu  Gln Thr Leu Ile Val  Thr His Leu 
    1220                 1225                 1230             


Asn Glu  Asp Arg Arg Val Leu  Asn Ser Met Ile His  Asp Ala Arg 
    1235                 1240                 1245             


Glu Lys  Ala Gly Glu Leu Gly  Lys Glu Gln Val Met  Val Pro Val 
    1250                 1255                 1260             


Leu Asn  Thr Ala Asn Ile Arg  Asp Gly Glu Leu Arg  Arg Leu Ser 
    1265                 1270                 1275             


Thr Trp  Glu Lys Asn Pro Asp  Ala Leu Ala Leu Val  Asp Asn Val 
    1280                 1285                 1290             


Tyr His  Arg Ile Ala Gly Ile  Ser Lys Asp Asp Gly  Leu Ile Thr 
    1295                 1300                 1305             


Leu Gln  Asp Ala Glu Gly Asn  Thr Arg Leu Ile Ser  Pro Arg Glu 
    1310                 1315                 1320             


Ala Val  Ala Glu Gly Val Thr  Leu Tyr Thr Pro Asp  Lys Ile Arg 
    1325                 1330                 1335             


Val Gly  Thr Gly Asp Arg Met  Arg Phe Thr Lys Ser  Asp Arg Glu 
    1340                 1345                 1350             


Arg Gly  Tyr Val Ala Asn Ser  Val Trp Thr Val Thr  Ala Val Ser 
    1355                 1360                 1365             


Gly Asp  Ser Val Thr Leu Ser  Asp Gly Gln Gln Thr  Arg Val Ile 
    1370                 1375                 1380             


Arg Pro  Gly Gln Glu Arg Ala  Glu Gln His Ile Asp  Leu Ala Tyr 
    1385                 1390                 1395             


Ala Ile  Thr Ala His Gly Ala  Gln Gly Ala Ser Glu  Thr Phe Ala 
    1400                 1405                 1410             


Ile Ala  Leu Glu Gly Thr Glu  Gly Asn Arg Lys Leu  Met Ala Gly 
    1415                 1420                 1425             


Phe Glu  Ser Ala Tyr Val Ala  Leu Ser Arg Met Lys  Gln His Val 
    1430                 1435                 1440             


Gln Val  Tyr Thr Asp Asn Arg  Gln Gly Trp Thr Asp  Ala Ile Asn 
    1445                 1450                 1455             


Asn Ala  Val Gln Lys Gly Thr  Ala His Asp Val Leu  Glu Pro Lys 
    1460                 1465                 1470             


Pro Asp  Arg Glu Val Met Asn  Ala Gln Arg Leu Phe  Ser Thr Ala 
    1475                 1480                 1485             


Arg Glu  Leu Arg Asp Val Ala  Ala Gly Arg Ala Val  Leu Arg Gln 
    1490                 1495                 1500             


Ala Gly  Leu Ala Gly Gly Asp  Ser Pro Ala Arg Phe  Ile Ala Pro 
    1505                 1510                 1515             


Gly Arg  Lys Tyr Pro Gln Pro  Tyr Val Ala Leu Pro  Ala Phe Asp 
    1520                 1525                 1530             


Arg Asn  Gly Lys Ser Ala Gly  Ile Trp Leu Asn Pro  Leu Thr Thr 
    1535                 1540                 1545             


Asp Asp  Gly Asn Gly Leu Arg  Gly Phe Ser Gly Glu  Gly Arg Val 
    1550                 1555                 1560             


Lys Gly  Ser Gly Asp Ala Gln  Phe Val Ala Leu Gln  Gly Ser Arg 
    1565                 1570                 1575             


Asn Gly  Glu Ser Leu Leu Ala  Asp Asn Met Gln Asp  Gly Val Arg 
    1580                 1585                 1590             


Ile Ala  Arg Asp Asn Pro Asp  Ser Gly Val Val Val  Arg Ile Ala 
    1595                 1600                 1605             


Gly Glu  Gly Arg Pro Trp Asn  Pro Gly Ala Ile Thr  Gly Gly Arg 
    1610                 1615                 1620             


Val Trp  Gly Asp Ile Pro Asp  Asn Ser Val Gln Pro  Gly Ala Gly 
    1625                 1630                 1635             


Asn Gly  Glu Pro Val Thr Ala  Glu Val Leu Ala Gln  Arg Gln Ala 
    1640                 1645                 1650             


Glu Glu  Ala Ile Arg Arg Glu  Thr Glu Arg Arg Ala  Asp Glu Ile 
    1655                 1660                 1665             


Val Arg  Lys Met Ala Glu Asn  Lys Pro Asp Leu Pro  Asp Gly Lys 
    1670                 1675                 1680             


Thr Glu  Leu Ala Val Arg Asp  Ile Ala Gly Gln Glu  Arg Asp Arg 
    1685                 1690                 1695             


Ser Ala  Ile Ser Glu Arg Glu  Thr Ala Leu Pro Glu  Ser Val Leu 
    1700                 1705                 1710             


Arg Glu  Ser Gln Arg Glu Arg  Glu Ala Val Arg Glu  Val Ala Arg 
    1715                 1720                 1725             


Glu Asn  Leu Leu Gln Glu Arg  Leu Gln Gln Met Glu  Arg Asp Met 
    1730                 1735                 1740             


Val Arg  Asp Leu Gln Lys Glu  Lys Thr Leu Gly Gly  Asp 
    1745                 1750                 1755     


<210>  47
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RecD-like motif I of TraI Eco

<400>  47

Gly Tyr Ala Gly Val Gly Lys Thr 
1               5               


<210>  48
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RecD-like motif V of TraI Eco

<400>  48

Tyr Ala Ile Thr Ala His Gly Ala Gln Gly 
1               5                   10  


<210>  49
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobF  motif III of TraI Eco

<400>  49

His Asp Thr Ser Arg Asp Gln Glu Pro Gln Leu His Thr His 
1               5                   10                  


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XPD motif V


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Any amino acid except D, E, K or R.  Preferably not charged or H.
       More preferably V, L, I, S or Y.

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Any amino acid except D, E, K or R.  Preferably not charged or H.

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Any amino acid.

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Any amino acid.  Preferably K, R or T.

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Any amino acid except D, E, K or R.  Preferably not charged or H.
       More preferably V, L, I, N or F.

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Any amino acid except D, E, K or R.  Preferably not charged or H.
       More preferably S or A.

<400>  50

Xaa Xaa Xaa Gly Xaa Xaa Xaa Glu Gly 
1               5                   


<210>  51
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XPD motif VI


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Any amino acid except D, E, K, R.  Typically G, P, A, V, L, I, M,
       C, F, Y, W, H, Q, N, S or T.  Preferably not charged.  Preferably
       not H.  More preferably V, A, L, I or M.

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Any amino acid except D, E, K, R.  Typically G, P, A, V, L, I, M,
       C, F, Y, W, H, Q, N, S or T.  Preferably not charged.  Preferably
       not H.  More preferably V, A, L, I, M or C.

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Any amino acid except D, E, K, R.  Typically G, P, A, V, L, I, M,
       C, F, Y, W, H, Q, N, S or T.  Preferably not charged.  Preferably
       not H.  More preferably I, H, L, F, M or V.

<220>
<221>  MISC_FEATURE
<222>  (9)..(11)
<223>  Any amino acid.

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  D or E

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Any amino acid.

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Any amino acid.  Preferably G, A, S or C

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  Any amino acid.

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Any amino acid. Preferably F, V, L, I, M, A, W or Y

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Any amino acid. Preferably L, F, Y, M, I or V.

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Any amino acid. Preferably A, C, V, L, I, M or S.

<400>  51

Gln Xaa Xaa Gly Arg Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Asp Asn Arg 
            20          


<210>  52
<211>  726
<212>  PRT
<213>  Methanococcoides burtonii

<400>  52

Met Ser Asp Lys Pro Ala Phe Met Lys Tyr Phe Thr Gln Ser Ser Cys 
1               5                   10                  15      


Tyr Pro Asn Gln Gln Glu Ala Met Asp Arg Ile His Ser Ala Leu Met 
            20                  25                  30          


Gln Gln Gln Leu Val Leu Phe Glu Gly Ala Cys Gly Thr Gly Lys Thr 
        35                  40                  45              


Leu Ser Ala Leu Val Pro Ala Leu His Val Gly Lys Met Leu Gly Lys 
    50                  55                  60                  


Thr Val Ile Ile Ala Thr Asn Val His Gln Gln Met Val Gln Phe Ile 
65                  70                  75                  80  


Asn Glu Ala Arg Asp Ile Lys Lys Val Gln Asp Val Lys Val Ala Val 
                85                  90                  95      


Ile Lys Gly Lys Thr Ala Met Cys Pro Gln Glu Ala Asp Tyr Glu Glu 
            100                 105                 110         


Cys Ser Val Lys Arg Glu Asn Thr Phe Glu Leu Met Glu Thr Glu Arg 
        115                 120                 125             


Glu Ile Tyr Leu Lys Arg Gln Glu Leu Asn Ser Ala Arg Asp Ser Tyr 
    130                 135                 140                 


Lys Lys Ser His Asp Pro Ala Phe Val Thr Leu Arg Asp Glu Leu Ser 
145                 150                 155                 160 


Lys Glu Ile Asp Ala Val Glu Glu Lys Ala Arg Gly Leu Arg Asp Arg 
                165                 170                 175     


Ala Cys Asn Asp Leu Tyr Glu Val Leu Arg Ser Asp Ser Glu Lys Phe 
            180                 185                 190         


Arg Glu Trp Leu Tyr Lys Glu Val Arg Ser Pro Glu Glu Ile Asn Asp 
        195                 200                 205             


His Ala Ile Lys Asp Gly Met Cys Gly Tyr Glu Leu Val Lys Arg Glu 
    210                 215                 220                 


Leu Lys His Ala Asp Leu Leu Ile Cys Asn Tyr His His Val Leu Asn 
225                 230                 235                 240 


Pro Asp Ile Phe Ser Thr Val Leu Gly Trp Ile Glu Lys Glu Pro Gln 
                245                 250                 255     


Glu Thr Ile Val Ile Phe Asp Glu Ala His Asn Leu Glu Ser Ala Ala 
            260                 265                 270         


Arg Ser His Ser Ser Leu Ser Leu Thr Glu His Ser Ile Glu Lys Ala 
        275                 280                 285             


Ile Thr Glu Leu Glu Ala Asn Leu Asp Leu Leu Ala Asp Asp Asn Ile 
    290                 295                 300                 


His Asn Leu Phe Asn Ile Phe Leu Glu Val Ile Ser Asp Thr Tyr Asn 
305                 310                 315                 320 


Ser Arg Phe Lys Phe Gly Glu Arg Glu Arg Val Arg Lys Asn Trp Tyr 
                325                 330                 335     


Asp Ile Arg Ile Ser Asp Pro Tyr Glu Arg Asn Asp Ile Val Arg Gly 
            340                 345                 350         


Lys Phe Leu Arg Gln Ala Lys Gly Asp Phe Gly Glu Lys Asp Asp Ile 
        355                 360                 365             


Gln Ile Leu Leu Ser Glu Ala Ser Glu Leu Gly Ala Lys Leu Asp Glu 
    370                 375                 380                 


Thr Tyr Arg Asp Gln Tyr Lys Lys Gly Leu Ser Ser Val Met Lys Arg 
385                 390                 395                 400 


Ser His Ile Arg Tyr Val Ala Asp Phe Met Ser Ala Tyr Ile Glu Leu 
                405                 410                 415     


Ser His Asn Leu Asn Tyr Tyr Pro Ile Leu Asn Val Arg Arg Asp Met 
            420                 425                 430         


Asn Asp Glu Ile Tyr Gly Arg Val Glu Leu Phe Thr Cys Ile Pro Lys 
        435                 440                 445             


Asn Val Thr Glu Pro Leu Phe Asn Ser Leu Phe Ser Val Ile Leu Met 
    450                 455                 460                 


Ser Ala Thr Leu His Pro Phe Glu Met Val Lys Lys Thr Leu Gly Ile 
465                 470                 475                 480 


Thr Arg Asp Thr Cys Glu Met Ser Tyr Gly Thr Ser Phe Pro Glu Glu 
                485                 490                 495     


Lys Arg Leu Ser Ile Ala Val Ser Ile Pro Pro Leu Phe Ala Lys Asn 
            500                 505                 510         


Arg Asp Asp Arg His Val Thr Glu Leu Leu Glu Gln Val Leu Leu Asp 
        515                 520                 525             


Ser Ile Glu Asn Ser Lys Gly Asn Val Ile Leu Phe Phe Gln Ser Ala 
    530                 535                 540                 


Phe Glu Ala Lys Arg Tyr Tyr Ser Lys Ile Glu Pro Leu Val Asn Val 
545                 550                 555                 560 


Pro Val Phe Leu Asp Glu Val Gly Ile Ser Ser Gln Asp Val Arg Glu 
                565                 570                 575     


Glu Phe Phe Ser Ile Gly Glu Glu Asn Gly Lys Ala Val Leu Leu Ser 
            580                 585                 590         


Tyr Leu Trp Gly Thr Leu Ser Glu Gly Ile Asp Tyr Arg Asp Gly Arg 
        595                 600                 605             


Gly Arg Thr Val Ile Ile Ile Gly Val Gly Tyr Pro Ala Leu Asn Asp 
    610                 615                 620                 


Arg Met Asn Ala Val Glu Ser Ala Tyr Asp His Val Phe Gly Tyr Gly 
625                 630                 635                 640 


Ala Gly Trp Glu Phe Ala Ile Gln Val Pro Thr Ile Arg Lys Ile Arg 
                645                 650                 655     


Gln Ala Met Gly Arg Val Val Arg Ser Pro Thr Asp Tyr Gly Ala Arg 
            660                 665                 670         


Ile Leu Leu Asp Gly Arg Phe Leu Thr Asp Ser Lys Lys Arg Phe Gly 
        675                 680                 685             


Lys Phe Ser Val Phe Glu Val Phe Pro Pro Ala Glu Arg Ser Glu Phe 
    690                 695                 700                 


Val Asp Val Asp Pro Glu Lys Val Lys Tyr Ser Leu Met Asn Phe Phe 
705                 710                 715                 720 


Met Asp Asn Asp Glu Gln 
                725     


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Motif V

<400>  53

Tyr Leu Trp Gly Thr Leu Ser Glu Gly 
1               5                   


<210>  54
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Motif VI

<400>  54

Gln Ala Met Gly Arg Val Val Arg Ser Pro Thr Asp Tyr Gly Ala Arg 
1               5                   10                  15      


Ile Leu Leu Asp Gly Arg 
            20          


<210>  55
<211>  65
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HhH domain

<400>  55

Gly Thr Gly Ser Gly Ala Trp Lys Glu Trp Leu Glu Arg Lys Val Gly 
1               5                   10                  15      


Glu Gly Arg Ala Arg Arg Leu Ile Glu Tyr Phe Gly Ser Ala Gly Glu 
            20                  25                  30          


Val Gly Lys Leu Val Glu Asn Ala Glu Val Ser Lys Leu Leu Glu Val 
        35                  40                  45              


Pro Gly Ile Gly Asp Glu Ala Val Ala Arg Leu Val Pro Gly Gly Ser 
    50                  55                  60                  


Ser 
65  


<210>  56
<211>  299
<212>  PRT
<213>  Bacteriophage RB69

<400>  56

Met Phe Lys Arg Lys Ser Thr Ala Asp Leu Ala Ala Gln Met Ala Lys 
1               5                   10                  15      


Leu Asn Gly Asn Lys Gly Phe Ser Ser Glu Asp Lys Gly Glu Trp Lys 
            20                  25                  30          


Leu Lys Leu Asp Ala Ser Gly Asn Gly Gln Ala Val Ile Arg Phe Leu 
        35                  40                  45              


Pro Ala Lys Thr Asp Asp Ala Leu Pro Phe Ala Ile Leu Val Asn His 
    50                  55                  60                  


Gly Phe Lys Lys Asn Gly Lys Trp Tyr Ile Glu Thr Cys Ser Ser Thr 
65                  70                  75                  80  


His Gly Asp Tyr Asp Ser Cys Pro Val Cys Gln Tyr Ile Ser Lys Asn 
                85                  90                  95      


Asp Leu Tyr Asn Thr Asn Lys Thr Glu Tyr Ser Gln Leu Lys Arg Lys 
            100                 105                 110         


Thr Ser Tyr Trp Ala Asn Ile Leu Val Val Lys Asp Pro Gln Ala Pro 
        115                 120                 125             


Asp Asn Glu Gly Lys Val Phe Lys Tyr Arg Phe Gly Lys Lys Ile Trp 
    130                 135                 140                 


Asp Lys Ile Asn Ala Met Ile Ala Val Asp Thr Glu Met Gly Glu Thr 
145                 150                 155                 160 


Pro Val Asp Val Thr Cys Pro Trp Glu Gly Ala Asn Phe Val Leu Lys 
                165                 170                 175     


Val Lys Gln Val Ser Gly Phe Ser Asn Tyr Asp Glu Ser Lys Phe Leu 
            180                 185                 190         


Asn Gln Ser Ala Ile Pro Asn Ile Asp Asp Glu Ser Phe Gln Lys Glu 
        195                 200                 205             


Leu Phe Glu Gln Met Val Asp Leu Ser Glu Met Thr Ser Lys Asp Lys 
    210                 215                 220                 


Phe Lys Ser Phe Glu Glu Leu Asn Thr Lys Phe Asn Gln Val Leu Gly 
225                 230                 235                 240 


Thr Ala Ala Leu Gly Gly Ala Ala Ala Ala Ala Ala Ser Val Ala Asp 
                245                 250                 255     


Lys Val Ala Ser Asp Leu Asp Asp Phe Asp Lys Asp Met Glu Ala Phe 
            260                 265                 270         


Ser Ser Ala Lys Thr Glu Asp Asp Phe Met Ser Ser Ser Ser Ser Asp 
        275                 280                 285             


Asp Gly Asp Leu Asp Asp Leu Leu Ala Gly Leu 
    290                 295                 


<210>  57
<211>  232
<212>  PRT
<213>  Bacteriophage T7

<400>  57

Met Ala Lys Lys Ile Phe Thr Ser Ala Leu Gly Thr Ala Glu Pro Tyr 
1               5                   10                  15      


Ala Tyr Ile Ala Lys Pro Asp Tyr Gly Asn Glu Glu Arg Gly Phe Gly 
            20                  25                  30          


Asn Pro Arg Gly Val Tyr Lys Val Asp Leu Thr Ile Pro Asn Lys Asp 
        35                  40                  45              


Pro Arg Cys Gln Arg Met Val Asp Glu Ile Val Lys Cys His Glu Glu 
    50                  55                  60                  


Ala Tyr Ala Ala Ala Val Glu Glu Tyr Glu Ala Asn Pro Pro Ala Val 
65                  70                  75                  80  


Ala Arg Gly Lys Lys Pro Leu Lys Pro Tyr Glu Gly Asp Met Pro Phe 
                85                  90                  95      


Phe Asp Asn Gly Asp Gly Thr Thr Thr Phe Lys Phe Lys Cys Tyr Ala 
            100                 105                 110         


Ser Phe Gln Asp Lys Lys Thr Lys Glu Thr Lys His Ile Asn Leu Val 
        115                 120                 125             


Val Val Asp Ser Lys Gly Lys Lys Met Glu Asp Val Pro Ile Ile Gly 
    130                 135                 140                 


Gly Gly Ser Lys Leu Lys Val Lys Tyr Ser Leu Val Pro Tyr Lys Trp 
145                 150                 155                 160 


Asn Thr Ala Val Gly Ala Ser Val Lys Leu Gln Leu Glu Ser Val Met 
                165                 170                 175     


Leu Val Glu Leu Ala Thr Phe Gly Gly Gly Glu Asp Asp Trp Ala Asp 
            180                 185                 190         


Glu Val Glu Glu Asn Gly Tyr Val Ala Ser Gly Ser Ala Lys Ala Ser 
        195                 200                 205             


Lys Pro Arg Asp Glu Glu Ser Trp Asp Glu Asp Asp Glu Glu Ser Glu 
    210                 215                 220                 


Glu Ala Asp Glu Asp Gly Asp Phe 
225                 230         


<210>  58
<211>  324
<212>  PRT
<213>  Herpes simplex virus 1

<400>  58

Met Asp Ser Pro Gly Gly Val Ala Pro Ala Ser Pro Val Glu Asp Ala 
1               5                   10                  15      


Ser Asp Ala Ser Leu Gly Gln Pro Glu Glu Gly Ala Pro Cys Gln Val 
            20                  25                  30          


Val Leu Gln Gly Ala Glu Leu Asn Gly Ile Leu Gln Ala Phe Ala Pro 
        35                  40                  45              


Leu Arg Thr Ser Leu Leu Asp Ser Leu Leu Val Met Gly Asp Arg Gly 
    50                  55                  60                  


Ile Leu Ile His Asn Thr Ile Phe Gly Glu Gln Val Phe Leu Pro Leu 
65                  70                  75                  80  


Glu His Ser Gln Phe Ser Arg Tyr Arg Trp Arg Gly Pro Thr Ala Ala 
                85                  90                  95      


Phe Leu Ser Leu Val Asp Gln Lys Arg Ser Leu Leu Ser Val Phe Arg 
            100                 105                 110         


Ala Asn Gln Tyr Pro Asp Leu Arg Arg Val Glu Leu Ala Ile Thr Gly 
        115                 120                 125             


Gln Ala Pro Phe Arg Thr Leu Val Gln Arg Ile Trp Thr Thr Thr Ser 
    130                 135                 140                 


Asp Gly Glu Ala Val Glu Leu Ala Ser Glu Thr Leu Met Lys Arg Glu 
145                 150                 155                 160 


Leu Thr Ser Phe Val Val Leu Val Pro Gln Gly Thr Pro Asp Val Gln 
                165                 170                 175     


Leu Arg Leu Thr Arg Pro Gln Leu Thr Lys Val Leu Asn Ala Thr Gly 
            180                 185                 190         


Ala Asp Ser Ala Thr Pro Thr Thr Phe Glu Leu Gly Val Asn Gly Lys 
        195                 200                 205             


Phe Ser Val Phe Thr Thr Ser Thr Cys Val Thr Phe Ala Ala Arg Glu 
    210                 215                 220                 


Glu Gly Val Ser Ser Ser Thr Ser Thr Gln Val Gln Ile Leu Ser Asn 
225                 230                 235                 240 


Ala Leu Thr Lys Ala Gly Gln Ala Ala Ala Asn Ala Lys Thr Val Tyr 
                245                 250                 255     


Gly Glu Asn Thr His Arg Thr Phe Ser Val Val Val Asp Asp Cys Ser 
            260                 265                 270         


Met Arg Ala Val Leu Arg Arg Leu Gln Val Gly Gly Gly Thr Leu Lys 
        275                 280                 285             


Phe Phe Leu Thr Thr Pro Val Pro Ser Leu Cys Val Thr Ala Thr Gly 
    290                 295                 300                 


Pro Asn Ala Val Ser Ala Val Phe Leu Leu Lys Pro Gln Lys His His 
305                 310                 315                 320 


His His His His 
                


<210>  59
<211>  251
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PCNA subunit 1

<400>  59

Met Phe Lys Ile Val Tyr Pro Asn Ala Lys Asp Phe Phe Ser Phe Ile 
1               5                   10                  15      


Asn Ser Ile Thr Asn Val Thr Asp Ser Ile Ile Leu Asn Phe Thr Glu 
            20                  25                  30          


Asp Gly Ile Phe Ser Arg His Leu Thr Glu Asp Lys Val Leu Met Ala 
        35                  40                  45              


Ile Met Arg Ile Pro Lys Asp Val Leu Ser Glu Tyr Ser Ile Asp Ser 
    50                  55                  60                  


Pro Thr Ser Val Lys Leu Asp Val Ser Ser Val Lys Lys Ile Leu Ser 
65                  70                  75                  80  


Lys Ala Ser Ser Lys Lys Ala Thr Ile Glu Leu Thr Glu Thr Asp Ser 
                85                  90                  95      


Gly Leu Lys Ile Ile Ile Arg Asp Glu Lys Ser Gly Ala Lys Ser Thr 
            100                 105                 110         


Ile Tyr Ile Lys Ala Glu Lys Gly Gln Val Glu Gln Leu Thr Glu Pro 
        115                 120                 125             


Lys Val Asn Leu Ala Val Asn Phe Thr Thr Asp Glu Ser Val Leu Asn 
    130                 135                 140                 


Val Ile Ala Ala Asp Val Thr Leu Val Gly Glu Glu Met Arg Ile Ser 
145                 150                 155                 160 


Thr Glu Glu Asp Lys Ile Lys Ile Glu Ala Gly Glu Glu Gly Lys Arg 
                165                 170                 175     


Tyr Val Ala Phe Leu Met Lys Asp Lys Pro Leu Lys Glu Leu Ser Ile 
            180                 185                 190         


Asp Thr Ser Ala Ser Ser Ser Tyr Ser Ala Glu Met Phe Lys Asp Ala 
        195                 200                 205             


Val Lys Gly Leu Arg Gly Phe Ser Ala Pro Thr Met Val Ser Phe Gly 
    210                 215                 220                 


Glu Asn Leu Pro Met Lys Ile Asp Val Glu Ala Val Ser Gly Gly His 
225                 230                 235                 240 


Met Ile Phe Trp Ile Ala Pro Arg Leu Leu Glu 
                245                 250     


<210>  60
<211>  245
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PCNA subunit 2

<400>  60

Met Lys Ala Lys Val Ile Asp Ala Val Ser Phe Ser Tyr Ile Leu Arg 
1               5                   10                  15      


Thr Val Gly Asp Phe Leu Ser Glu Ala Asn Phe Ile Val Thr Lys Glu 
            20                  25                  30          


Gly Ile Arg Val Ser Gly Ile Asp Pro Ser Arg Val Val Phe Leu Asp 
        35                  40                  45              


Ile Phe Leu Pro Ser Ser Tyr Phe Glu Gly Phe Glu Val Ser Gln Glu 
    50                  55                  60                  


Lys Glu Ile Ile Gly Phe Lys Leu Glu Asp Val Asn Asp Ile Leu Lys 
65                  70                  75                  80  


Arg Val Leu Lys Asp Asp Thr Leu Ile Leu Ser Ser Asn Glu Ser Lys 
                85                  90                  95      


Leu Thr Leu Thr Phe Asp Gly Glu Phe Thr Arg Ser Phe Glu Leu Pro 
            100                 105                 110         


Leu Ile Gln Val Glu Ser Thr Gln Pro Pro Ser Val Asn Leu Glu Phe 
        115                 120                 125             


Pro Phe Lys Ala Gln Leu Leu Thr Ile Thr Phe Ala Asp Ile Ile Asp 
    130                 135                 140                 


Glu Leu Ser Asp Leu Gly Glu Val Leu Asn Ile His Ser Lys Glu Asn 
145                 150                 155                 160 


Lys Leu Tyr Phe Glu Val Ile Gly Asp Leu Ser Thr Ala Lys Val Glu 
                165                 170                 175     


Leu Ser Thr Asp Asn Gly Thr Leu Leu Glu Ala Ser Gly Ala Asp Val 
            180                 185                 190         


Ser Ser Ser Tyr Gly Met Glu Tyr Val Ala Asn Thr Thr Lys Met Arg 
        195                 200                 205             


Arg Ala Ser Asp Ser Met Glu Leu Tyr Phe Gly Ser Gln Ile Pro Leu 
    210                 215                 220                 


Lys Leu Arg Phe Lys Leu Pro Gln Glu Gly Tyr Gly Asp Phe Tyr Ile 
225                 230                 235                 240 


Ala Pro Arg Ala Asp 
                245 


<210>  61
<211>  246
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PCNA subunit 3

<400>  61

Met Lys Val Val Tyr Asp Asp Val Arg Val Leu Lys Asp Ile Ile Gln 
1               5                   10                  15      


Ala Leu Ala Arg Leu Val Asp Glu Ala Val Leu Lys Phe Lys Gln Asp 
            20                  25                  30          


Ser Val Glu Leu Val Ala Leu Asp Arg Ala His Ile Ser Leu Ile Ser 
        35                  40                  45              


Val Asn Leu Pro Arg Glu Met Phe Lys Glu Tyr Asp Val Asn Asp Glu 
    50                  55                  60                  


Phe Lys Phe Gly Phe Asn Thr Gln Tyr Leu Met Lys Ile Leu Lys Val 
65                  70                  75                  80  


Ala Lys Arg Lys Glu Ala Ile Glu Ile Ala Ser Glu Ser Pro Asp Ser 
                85                  90                  95      


Val Ile Ile Asn Ile Ile Gly Ser Thr Asn Arg Glu Phe Asn Val Arg 
            100                 105                 110         


Asn Leu Glu Val Ser Glu Gln Glu Ile Pro Glu Ile Asn Leu Gln Phe 
        115                 120                 125             


Asp Ile Ser Ala Thr Ile Ser Ser Asp Gly Phe Lys Ser Ala Ile Ser 
    130                 135                 140                 


Glu Val Ser Thr Val Thr Asp Asn Val Val Val Glu Gly His Glu Asp 
145                 150                 155                 160 


Arg Ile Leu Ile Lys Ala Glu Gly Glu Ser Glu Val Glu Val Glu Phe 
                165                 170                 175     


Ser Lys Asp Thr Gly Gly Leu Gln Asp Leu Glu Phe Ser Lys Glu Ser 
            180                 185                 190         


Lys Asn Ser Tyr Ser Ala Glu Tyr Leu Asp Asp Val Leu Ser Leu Thr 
        195                 200                 205             


Lys Leu Ser Asp Tyr Val Lys Ile Ser Phe Gly Asn Gln Lys Pro Leu 
    210                 215                 220                 


Gln Leu Phe Phe Asn Met Glu Gly Gly Gly Lys Val Thr Tyr Leu Leu 
225                 230                 235                 240 


Ala Pro Lys Val Leu Glu 
                245     


<210>  62
<211>  608
<212>  PRT
<213>  Bacteriophage phi-29

<400>  62

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Ala Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys Ser 
                565                 570                 575     


Gly Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        595                 600                 605             


<210>  63
<211>  318
<212>  PRT
<213>  Herpes simplex virus 1

<400>  63

Thr Asp Ser Pro Gly Gly Val Ala Pro Ala Ser Pro Val Glu Asp Ala 
1               5                   10                  15      


Ser Asp Ala Ser Leu Gly Gln Pro Glu Glu Gly Ala Pro Cys Gln Val 
            20                  25                  30          


Val Leu Gln Gly Ala Glu Leu Asn Gly Ile Leu Gln Ala Phe Ala Pro 
        35                  40                  45              


Leu Arg Thr Ser Leu Leu Asp Ser Leu Leu Val Met Gly Asp Arg Gly 
    50                  55                  60                  


Ile Leu Ile His Asn Thr Ile Phe Gly Glu Gln Val Phe Leu Pro Leu 
65                  70                  75                  80  


Glu His Ser Gln Phe Ser Arg Tyr Arg Trp Arg Gly Pro Thr Ala Ala 
                85                  90                  95      


Phe Leu Ser Leu Val Asp Gln Lys Arg Ser Leu Leu Ser Val Phe Arg 
            100                 105                 110         


Ala Asn Gln Tyr Pro Asp Leu Arg Arg Val Glu Leu Ala Ile Thr Gly 
        115                 120                 125             


Gln Ala Pro Phe Arg Thr Leu Val Gln Arg Ile Trp Thr Thr Thr Ser 
    130                 135                 140                 


Asp Gly Glu Ala Val Glu Leu Ala Ser Glu Thr Leu Met Lys Arg Glu 
145                 150                 155                 160 


Leu Thr Ser Phe Val Val Leu Val Pro Gln Gly Thr Pro Asp Val Gln 
                165                 170                 175     


Leu Arg Leu Thr Arg Pro Gln Leu Thr Lys Val Leu Asn Ala Thr Gly 
            180                 185                 190         


Ala Asp Ser Ala Thr Pro Thr Thr Phe Glu Leu Gly Val Asn Gly Lys 
        195                 200                 205             


Phe Ser Val Phe Thr Thr Ser Thr Cys Val Thr Phe Ala Ala Arg Glu 
    210                 215                 220                 


Glu Gly Val Ser Ser Ser Thr Ser Thr Gln Val Gln Ile Leu Ser Asn 
225                 230                 235                 240 


Ala Leu Thr Lys Ala Gly Gln Ala Ala Ala Asn Ala Lys Thr Val Tyr 
                245                 250                 255     


Gly Glu Asn Thr His Arg Thr Phe Ser Val Val Val Asp Asp Cys Ser 
            260                 265                 270         


Met Arg Ala Val Leu Arg Arg Leu Gln Val Gly Gly Gly Thr Leu Lys 
        275                 280                 285             


Phe Phe Leu Thr Thr Pro Val Pro Ser Leu Cys Val Thr Ala Thr Gly 
    290                 295                 300                 


Pro Asn Ala Val Ser Ala Val Phe Leu Leu Lys Pro Gln Lys 
305                 310                 315             


<210>  64
<211>  233
<212>  PRT
<213>  Bacteriophage RB69

<400>  64

Lys Gly Phe Ser Ser Glu Asp Lys Gly Glu Trp Lys Leu Lys Leu Asp 
1               5                   10                  15      


Ala Ser Gly Asn Gly Gln Ala Val Ile Arg Phe Leu Pro Ala Lys Thr 
            20                  25                  30          


Asp Asp Ala Leu Pro Phe Ala Ile Leu Val Asn His Gly Phe Lys Lys 
        35                  40                  45              


Asn Gly Lys Trp Tyr Ile Glu Thr Cys Ser Ser Thr His Gly Asp Tyr 
    50                  55                  60                  


Asp Ser Cys Pro Val Cys Gln Tyr Ile Ser Lys Asn Asp Leu Tyr Asn 
65                  70                  75                  80  


Thr Asn Lys Thr Glu Tyr Ser Gln Leu Lys Arg Lys Thr Ser Tyr Trp 
                85                  90                  95      


Ala Asn Ile Leu Val Val Lys Asp Pro Gln Ala Pro Asp Asn Glu Gly 
            100                 105                 110         


Lys Val Phe Lys Tyr Arg Phe Gly Lys Lys Ile Trp Asp Lys Ile Asn 
        115                 120                 125             


Ala Met Ile Ala Val Asp Thr Glu Met Gly Glu Thr Pro Val Asp Val 
    130                 135                 140                 


Thr Cys Pro Trp Glu Gly Ala Asn Phe Val Leu Lys Val Lys Gln Val 
145                 150                 155                 160 


Ser Gly Phe Ser Asn Tyr Asp Glu Ser Lys Phe Leu Asn Gln Ser Ala 
                165                 170                 175     


Ile Pro Asn Ile Asp Asp Glu Ser Phe Gln Lys Glu Leu Phe Glu Gln 
            180                 185                 190         


Met Val Asp Leu Ser Glu Met Thr Ser Lys Asp Lys Phe Lys Ser Phe 
        195                 200                 205             


Glu Glu Leu Asn Thr Lys Phe Asn Gln Val Leu Gly Thr Ala Ala Leu 
    210                 215                 220                 


Gly Gly Ala Ala Ala Ala Ala Ala Ser 
225                 230             


<210>  65
<211>  210
<212>  PRT
<213>  Bacteriophage T7

<400>  65

Ala Lys Lys Ile Phe Thr Ser Ala Leu Gly Thr Ala Glu Pro Tyr Ala 
1               5                   10                  15      


Tyr Ile Ala Lys Pro Asp Tyr Gly Asn Glu Glu Arg Gly Phe Gly Asn 
            20                  25                  30          


Pro Arg Gly Val Tyr Lys Val Asp Leu Thr Ile Pro Asn Lys Asp Pro 
        35                  40                  45              


Arg Cys Gln Arg Met Val Asp Glu Ile Val Lys Cys His Glu Glu Ala 
    50                  55                  60                  


Tyr Ala Ala Ala Val Glu Glu Tyr Glu Ala Asn Pro Pro Ala Val Ala 
65                  70                  75                  80  


Arg Gly Lys Lys Pro Leu Lys Pro Tyr Glu Gly Asp Met Pro Phe Phe 
                85                  90                  95      


Asp Asn Gly Asp Gly Thr Thr Thr Phe Lys Phe Lys Cys Tyr Ala Ser 
            100                 105                 110         


Phe Gln Asp Lys Lys Thr Lys Glu Thr Lys His Ile Asn Leu Val Val 
        115                 120                 125             


Val Asp Ser Lys Gly Lys Lys Met Glu Asp Val Pro Ile Ile Gly Gly 
    130                 135                 140                 


Gly Ser Lys Leu Lys Val Lys Tyr Ser Leu Val Pro Tyr Lys Trp Asn 
145                 150                 155                 160 


Thr Ala Val Gly Ala Ser Val Lys Leu Gln Leu Glu Ser Val Met Leu 
                165                 170                 175     


Val Glu Leu Ala Thr Phe Gly Gly Gly Glu Asp Asp Trp Ala Asp Glu 
            180                 185                 190         


Val Glu Glu Asn Gly Tyr Val Ala Ser Gly Ser Ala Lys Ala Ser Lys 
        195                 200                 205             


Pro Arg 
    210 


<210>  66
<211>  99
<212>  PRT
<213>  Halorubrum lacusprofundi

<400>  66

Ser Gly Glu Glu Leu Leu Asp Leu Ala Gly Val Arg Asn Val Gly Arg 
1               5                   10                  15      


Lys Arg Ala Arg Arg Leu Phe Glu Ala Gly Ile Glu Thr Arg Ala Asp 
            20                  25                  30          


Leu Arg Glu Ala Asp Lys Ala Val Val Leu Gly Ala Leu Arg Gly Arg 
        35                  40                  45              


Glu Arg Thr Ala Glu Arg Ile Leu Glu His Ala Gly Arg Glu Asp Pro 
    50                  55                  60                  


Ser Met Asp Asp Val Arg Pro Asp Lys Ser Ala Ser Ala Ala Ala Thr 
65                  70                  75                  80  


Ala Gly Ser Ala Ser Asp Glu Asp Gly Glu Gly Gln Ala Ser Leu Gly 
                85                  90                  95      


Asp Phe Arg 
            


<210>  67
<211>  102
<212>  PRT
<213>  Haloferax volcanii

<400>  67

Ser Gly Glu Glu Leu Leu Asp Leu Ala Gly Val Arg Gly Val Gly Arg 
1               5                   10                  15      


Lys Arg Ala Arg Arg Leu Phe Glu Ala Gly Val Glu Thr Arg Ala Asp 
            20                  25                  30          


Leu Arg Glu Ala Asp Lys Pro Arg Val Leu Ala Ala Leu Arg Gly Arg 
        35                  40                  45              


Arg Lys Thr Ala Glu Asn Ile Leu Glu Ala Ala Gly Arg Lys Asp Pro 
    50                  55                  60                  


Ser Met Asp Ala Val Asp Glu Asp Asp Ala Pro Asp Asp Ala Val Pro 
65                  70                  75                  80  


Asp Asp Ala Gly Phe Glu Thr Ala Lys Glu Arg Ala Asp Gln Gln Ala 
                85                  90                  95      


Ser Leu Gly Asp Phe Glu 
            100         


<210>  68
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide used in the Examples

<400>  68
ggtgaggagg atggtgctac ggagactagg                                        30


<210>  69
<211>  88
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide used in the Examples

<400>  69
cgtggtcacg aggagctcgt cctcacctcg acgtctgcac gagctttttt tttttttttt       60

tttttttttt tttttttttt tttttttt                                          88


<210>  70
<211>  522
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide used in the Examples

<400>  70
tttttttttt tttttttttt tttttttttt tttttttttt tttttgccat cagattgtgt       60

ttgttagtcg ctggttgttt ctgttggtgc tgatattgct tttgatgccg accctaaatt      120

ttttgcctgt ttggttcgct ttgagtcttc ttcggttccg actaccctcc cgactgccta      180

tgatgtttat cctttgaatg gtcgccatga tggtggttat tataccgtca aggactgtgt      240

gactattgac gtccttcccc gtacgccggg caataacgtt tatgttggtt tcatggtttg      300

gtctaacttt accgctacta aatgccgcgg attggtttcg ctgaatcagg ttattaaaga      360

gattatttgt ctccagccac ttaagtgagg tgatttatgt ttggtgctat tgctggcggt      420

attgcttctg ctcttgctgg tggcgccatg tctaaattgt ttggaggcgg tctttttccc      480

cctttttccc cctttttccc cctttttccc cctttttccc cc                         522


<210>  71
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide used in the Examples

<400>  71
agcgactaac aaacacaatc tgatggcttt tttttttttt tttttttttt ttttttt          57


<210>  72
<211>  974
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide used in the Examples

<400>  72
tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt ggttgtttct       60

gttggtgctg atattgctgt gttctatgtc ttattctgtg tatgtatctt gtctgttagc      120

cccgattgtt accggataat tcgagctcgg tacccacccc ggttgataat cagaaaagcc      180

ccaaaaacag gaagattgta taagcaaata tttaaattgt aaacgttaat attttgttaa      240

aattcgcgtt aaatttttgt taaatcagct cattttttaa ccaataggcc gaaatcggca      300

aaatccctta taaatcaaaa gaatagaccg agatagggtt gagtgttgtt ccagtttgga      360

acaagagtcc agtattaaag aacgtggact ccaacgtcaa agggcgaaaa accgtctatc      420

agggcgatgg cccactacgt gaaccatcac cctaatcaag ttttttgggg tcgaggtgcc      480

gtaaagcact aaatcggaac cctaaaggga tgccccgatt tagagcttga cggggaaagc      540

cggcgaacgt ggcgagaaag gaagggaaga aagcgaaagg agcgggcgct agggcgctgg      600

caagtgtagc ggtcacgctg cgcgtaacca ccacacccgc cgcgcttaat gcgccgctac      660

agggcgcgtg gggatcctct agagtcgacc tgcaggcatg caagctatcc cgcaagaggc      720

ccggcagtac cggcataacc aagcctatgc ctacagcatc cagggtgacg gtgccgagga      780

tgacgatgag cgcattgtta gatttcatac acggtgcctg actgcgttag caatttaact      840

gtgataaact accgcattaa agctagctta tcgatgataa gctgtcaaac atgagaattc      900

ttgaagacga aagggcctcg tgatacgcct atttttatag gttaatgtca tgataataat      960

ggtttcttag acgt                                                        974


<210>  73
<211>  893
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide used in the Examples

<400>  73
ctaagaaacc attattatca tgacattaac ctataaaaat aggcgtatca cgaggccctt       60

tcgtcttcaa gaattctcat gtttgacagc ttatcatcga taagctagct ttaatgcggt      120

agtttatcac agttaaattg ctaacgcagt caggcaccgt gtatgaaatc taacaatgcg      180

ctcatcgtca tcctcggcac cgtcaccctg gatgctgtag gcataggctt ggttatgccg      240

gtactgccgg gcctcttgcg ggatagcttg catgcctgca ggtcgactct agaggatccc      300

cacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc      360

gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc      420

acgttcgccg gctttccccg tcaagctcta aatcggggca tccctttagg gttccgattt      480

agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg      540

ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatact      600

ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta      660

taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt      720

aacgcgaatt ttaacaaaat attaacgttt acaatttaaa tatttgctta tacaatcttc      780

ctgtttttgg ggcttttctg attatcaacc ggggtgggta ccgagctcga attatccggt      840

aacaatcggg gctaacagac aagatacata cacagaataa gacatagaac aca             893


<210>  74
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide used in the Examples

<400>  74
gcaatatcag caccaacaga aacaacct                                          28


<210>  75
<211>  55
<212>  PRT
<213>  Artificial sequence

<220>
<223>  (HhH)2 domain

<400>  75

Trp Lys Glu Trp Leu Glu Arg Lys Val Gly Glu Gly Arg Ala Arg Arg 
1               5                   10                  15      


Leu Ile Glu Tyr Phe Gly Ser Ala Gly Glu Val Gly Lys Leu Val Glu 
            20                  25                  30          


Asn Ala Glu Val Ser Lys Leu Leu Glu Val Pro Gly Ile Gly Asp Glu 
        35                  40                  45              


Ala Val Ala Arg Leu Val Pro 
    50                  55  


<210>  76
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  (HhH)2-(HhH)2 domain

<400>  76

Trp Lys Glu Trp Leu Glu Arg Lys Val Gly Glu Gly Arg Ala Arg Arg 
1               5                   10                  15      


Leu Ile Glu Tyr Phe Gly Ser Ala Gly Glu Val Gly Lys Leu Val Glu 
            20                  25                  30          


Asn Ala Glu Val Ser Lys Leu Leu Glu Val Pro Gly Ile Gly Asp Glu 
        35                  40                  45              


Ala Val Ala Arg Leu Val Pro Gly Tyr Lys Thr Leu Arg Asp Ala Gly 
    50                  55                  60                  


Leu Thr Pro Ala Glu Ala Glu Arg Val Leu Lys Arg Tyr Gly Ser Val 
65                  70                  75                  80  


Ser Lys Val Gln Glu Gly Ala Thr Pro Asp Glu Leu Arg Glu Leu Gly 
                85                  90                  95      


Leu Gly Asp Ala Lys Ile Ala Arg Ile Leu Gly 
            100                 105         


<210>  77
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  77

Glu Ser Glu Thr Thr Thr Ser Leu Val Leu Glu Arg Ser Leu Asn Arg 
1               5                   10                  15      


Val His Leu Leu Gly Arg Val Gly Gln Asp Pro Val Leu Arg Gln Val 
            20                  25                  30          


Glu Gly Lys Asn Pro Val Thr Ile Phe Ser Leu Ala Thr Asn Glu Met 
        35                  40                  45              


Trp Arg Ser Gly Asp Ser Glu Val Tyr Gln Leu Gly Asp Val Ser Gln 
    50                  55                  60                  


Lys Thr Thr Trp His Arg Ile Ser Val Phe Arg Pro Gly Leu Arg Asp 
65                  70                  75                  80  


Val Ala Tyr Gln Tyr Val Lys Lys Gly Ser Arg Ile Tyr Leu Glu Gly 
                85                  90                  95      


Lys Ile Asp Tyr Gly Glu Tyr Met Asp Lys Asn Asn Val Arg Arg Gln 
            100                 105                 110         


Ala Thr Thr Ile Ile Ala Asp Asn Ile Ile Phe Leu Ser Asp Gln Thr 
        115                 120                 125             


Lys Glu Lys Glu 
    130         


<210>  78
<211>  123
<212>  PRT
<213>  Bacteriophage phi-29

<400>  78

Glu Asn Thr Asn Ile Val Lys Ala Thr Phe Asp Thr Glu Thr Leu Glu 
1               5                   10                  15      


Gly Gln Ile Lys Ile Phe Asn Ala Gln Thr Gly Gly Gly Gln Ser Phe 
            20                  25                  30          


Lys Asn Leu Pro Asp Gly Thr Ile Ile Glu Ala Asn Ala Ile Ala Gln 
        35                  40                  45              


Tyr Lys Gln Val Ser Asp Thr Tyr Gly Asp Ala Lys Glu Glu Thr Val 
    50                  55                  60                  


Thr Thr Ile Phe Ala Ala Asp Gly Ser Leu Tyr Ser Ala Ile Ser Lys 
65                  70                  75                  80  


Thr Val Ala Glu Ala Ala Ser Asp Leu Ile Asp Leu Val Thr Arg His 
                85                  90                  95      


Lys Leu Glu Thr Phe Lys Val Lys Val Val Gln Gly Thr Ser Ser Lys 
            100                 105                 110         


Gly Asn Val Phe Phe Ser Leu Gln Leu Ser Leu 
        115                 120             


<210>  79
<211>  177
<212>  PRT
<213>  Escherichia coli

<400>  79

Ala Ser Arg Gly Val Asn Lys Val Ile Leu Val Gly Asn Leu Gly Gln 
1               5                   10                  15      


Asp Pro Glu Val Arg Tyr Met Pro Asn Gly Gly Ala Val Ala Asn Ile 
            20                  25                  30          


Thr Leu Ala Thr Ser Glu Ser Trp Arg Asp Lys Ala Thr Gly Glu Met 
        35                  40                  45              


Lys Glu Gln Thr Glu Trp His Arg Val Val Leu Phe Gly Lys Leu Ala 
    50                  55                  60                  


Glu Val Ala Ser Glu Tyr Leu Arg Lys Gly Ser Gln Val Tyr Ile Glu 
65                  70                  75                  80  


Gly Gln Leu Arg Thr Arg Lys Trp Thr Asp Gln Ser Gly Gln Asp Arg 
                85                  90                  95      


Tyr Thr Thr Glu Val Val Val Asn Val Gly Gly Thr Met Gln Met Leu 
            100                 105                 110         


Gly Gly Arg Gln Gly Gly Gly Ala Pro Ala Gly Gly Asn Ile Gly Gly 
        115                 120                 125             


Gly Gln Pro Gln Gly Gly Trp Gly Gln Pro Gln Gln Pro Gln Gly Gly 
    130                 135                 140                 


Asn Gln Phe Ser Gly Gly Ala Gln Ser Arg Pro Gln Gln Ser Ala Pro 
145                 150                 155                 160 


Ala Ala Pro Ser Asn Glu Pro Pro Met Asp Phe Asp Asp Asp Ile Pro 
                165                 170                 175     


Phe 
    


<210>  80
<211>  301
<212>  PRT
<213>  Bacteriophage T4

<400>  80

Met Phe Lys Arg Lys Ser Thr Ala Glu Leu Ala Ala Gln Met Ala Lys 
1               5                   10                  15      


Leu Asn Gly Asn Lys Gly Phe Ser Ser Glu Asp Lys Gly Glu Trp Lys 
            20                  25                  30          


Leu Lys Leu Asp Asn Ala Gly Asn Gly Gln Ala Val Ile Arg Phe Leu 
        35                  40                  45              


Pro Ser Lys Asn Asp Glu Gln Ala Pro Phe Ala Ile Leu Val Asn His 
    50                  55                  60                  


Gly Phe Lys Lys Asn Gly Lys Trp Tyr Ile Glu Thr Cys Ser Ser Thr 
65                  70                  75                  80  


His Gly Asp Tyr Asp Ser Cys Pro Val Cys Gln Tyr Ile Ser Lys Asn 
                85                  90                  95      


Asp Leu Tyr Asn Thr Asp Asn Lys Glu Tyr Ser Leu Val Lys Arg Lys 
            100                 105                 110         


Thr Ser Tyr Trp Ala Asn Ile Leu Val Val Lys Asp Pro Ala Ala Pro 
        115                 120                 125             


Glu Asn Glu Gly Lys Val Phe Lys Tyr Arg Phe Gly Lys Lys Ile Trp 
    130                 135                 140                 


Asp Lys Ile Asn Ala Met Ile Ala Val Asp Val Glu Met Gly Glu Thr 
145                 150                 155                 160 


Pro Val Asp Val Thr Cys Pro Trp Glu Gly Ala Asn Phe Val Leu Lys 
                165                 170                 175     


Val Lys Gln Val Ser Gly Phe Ser Asn Tyr Asp Glu Ser Lys Phe Leu 
            180                 185                 190         


Asn Gln Ser Ala Ile Pro Asn Ile Asp Asp Glu Ser Phe Gln Lys Glu 
        195                 200                 205             


Leu Phe Glu Gln Met Val Asp Leu Ser Glu Met Thr Ser Lys Asp Lys 
    210                 215                 220                 


Phe Lys Ser Phe Glu Glu Leu Asn Thr Lys Phe Gly Gln Val Met Gly 
225                 230                 235                 240 


Thr Ala Val Met Gly Gly Ala Ala Ala Thr Ala Ala Lys Lys Ala Asp 
                245                 250                 255     


Lys Val Ala Asp Asp Leu Asp Ala Phe Asn Val Asp Asp Phe Asn Thr 
            260                 265                 270         


Lys Thr Glu Asp Asp Phe Met Ser Ser Ser Ser Gly Ser Ser Ser Ser 
        275                 280                 285             


Ala Asp Asp Thr Asp Leu Asp Asp Leu Leu Asn Asp Leu 
    290                 295                 300     


<210>  81
<211>  177
<212>  PRT
<213>  Artificial sequence

<220>
<223>  EcoSSB-CterAla

<400>  81

Ala Ser Arg Gly Val Asn Lys Val Ile Leu Val Gly Asn Leu Gly Gln 
1               5                   10                  15      


Asp Pro Glu Val Arg Tyr Met Pro Asn Gly Gly Ala Val Ala Asn Ile 
            20                  25                  30          


Thr Leu Ala Thr Ser Glu Ser Trp Arg Asp Lys Ala Thr Gly Glu Met 
        35                  40                  45              


Lys Glu Gln Thr Glu Trp His Arg Val Val Leu Phe Gly Lys Leu Ala 
    50                  55                  60                  


Glu Val Ala Ser Glu Tyr Leu Arg Lys Gly Ser Gln Val Tyr Ile Glu 
65                  70                  75                  80  


Gly Gln Leu Arg Thr Arg Lys Trp Thr Asp Gln Ser Gly Gln Asp Arg 
                85                  90                  95      


Tyr Thr Thr Glu Val Val Val Asn Val Gly Gly Thr Met Gln Met Leu 
            100                 105                 110         


Gly Gly Arg Gln Gly Gly Gly Ala Pro Ala Gly Gly Asn Ile Gly Gly 
        115                 120                 125             


Gly Gln Pro Gln Gly Gly Trp Gly Gln Pro Gln Gln Pro Gln Gly Gly 
    130                 135                 140                 


Asn Gln Phe Ser Gly Gly Ala Gln Ser Arg Pro Gln Gln Ser Ala Pro 
145                 150                 155                 160 


Ala Ala Pro Ser Asn Glu Pro Pro Met Ala Phe Ala Ala Ala Ile Pro 
                165                 170                 175     


Phe 
    


<210>  82
<211>  177
<212>  PRT
<213>  Artificial sequence

<220>
<223>  EcoSSB-CterNGGN

<400>  82

Ala Ser Arg Gly Val Asn Lys Val Ile Leu Val Gly Asn Leu Gly Gln 
1               5                   10                  15      


Asp Pro Glu Val Arg Tyr Met Pro Asn Gly Gly Ala Val Ala Asn Ile 
            20                  25                  30          


Thr Leu Ala Thr Ser Glu Ser Trp Arg Asp Lys Ala Thr Gly Glu Met 
        35                  40                  45              


Lys Glu Gln Thr Glu Trp His Arg Val Val Leu Phe Gly Lys Leu Ala 
    50                  55                  60                  


Glu Val Ala Ser Glu Tyr Leu Arg Lys Gly Ser Gln Val Tyr Ile Glu 
65                  70                  75                  80  


Gly Gln Leu Arg Thr Arg Lys Trp Thr Asp Gln Ser Gly Gln Asp Arg 
                85                  90                  95      


Tyr Thr Thr Glu Val Val Val Asn Val Gly Gly Thr Met Gln Met Leu 
            100                 105                 110         


Gly Gly Arg Gln Gly Gly Gly Ala Pro Ala Gly Gly Asn Ile Gly Gly 
        115                 120                 125             


Gly Gln Pro Gln Gly Gly Trp Gly Gln Pro Gln Gln Pro Gln Gly Gly 
    130                 135                 140                 


Asn Gln Phe Ser Gly Gly Ala Gln Ser Arg Pro Gln Gln Ser Ala Pro 
145                 150                 155                 160 


Ala Ala Pro Ser Asn Glu Pro Pro Met Asn Phe Gly Gly Asn Ile Pro 
                165                 170                 175     


Phe 
    


<210>  83
<211>  152
<212>  PRT
<213>  Artificial sequence

<220>
<223>  EcoSSB-Q152del

<400>  83

Ala Ser Arg Gly Val Asn Lys Val Ile Leu Val Gly Asn Leu Gly Gln 
1               5                   10                  15      


Asp Pro Glu Val Arg Tyr Met Pro Asn Gly Gly Ala Val Ala Asn Ile 
            20                  25                  30          


Thr Leu Ala Thr Ser Glu Ser Trp Arg Asp Lys Ala Thr Gly Glu Met 
        35                  40                  45              


Lys Glu Gln Thr Glu Trp His Arg Val Val Leu Phe Gly Lys Leu Ala 
    50                  55                  60                  


Glu Val Ala Ser Glu Tyr Leu Arg Lys Gly Ser Gln Val Tyr Ile Glu 
65                  70                  75                  80  


Gly Gln Leu Arg Thr Arg Lys Trp Thr Asp Gln Ser Gly Gln Asp Arg 
                85                  90                  95      


Tyr Thr Thr Glu Val Val Val Asn Val Gly Gly Thr Met Gln Met Leu 
            100                 105                 110         


Gly Gly Arg Gln Gly Gly Gly Ala Pro Ala Gly Gly Asn Ile Gly Gly 
        115                 120                 125             


Gly Gln Pro Gln Gly Gly Trp Gly Gln Pro Gln Gln Pro Gln Gly Gly 
    130                 135                 140                 


Asn Gln Phe Ser Gly Gly Ala Gln 
145                 150         


<210>  84
<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  EcoSSB-G117del

<400>  84

Ala Ser Arg Gly Val Asn Lys Val Ile Leu Val Gly Asn Leu Gly Gln 
1               5                   10                  15      


Asp Pro Glu Val Arg Tyr Met Pro Asn Gly Gly Ala Val Ala Asn Ile 
            20                  25                  30          


Thr Leu Ala Thr Ser Glu Ser Trp Arg Asp Lys Ala Thr Gly Glu Met 
        35                  40                  45              


Lys Glu Gln Thr Glu Trp His Arg Val Val Leu Phe Gly Lys Leu Ala 
    50                  55                  60                  


Glu Val Ala Ser Glu Tyr Leu Arg Lys Gly Ser Gln Val Tyr Ile Glu 
65                  70                  75                  80  


Gly Gln Leu Arg Thr Arg Lys Trp Thr Asp Gln Ser Gly Gln Asp Arg 
                85                  90                  95      


Tyr Thr Thr Glu Val Val Val Asn Val Gly Gly Thr Met Gln Met Leu 
            100                 105                 110         


Gly Gly Arg Gln Gly 
        115         


<210>  85
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  85

Gly Thr Gly Ser Gly Ala 
1               5       


<210>  86
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  86

Gly Thr Gly Ser Gly Thr 
1               5       


<210>  87
<211>  970
<212>  PRT
<213>  Citromicrobium bathyomarinum JL354

<400>  87

Met Leu Ser Val Ala Asn Val Arg Ser Pro Ser Ala Ala Ala Ser Tyr 
1               5                   10                  15      


Phe Ala Ser Asp Asn Tyr Tyr Ala Ser Ala Asp Ala Asp Arg Ser Gly 
            20                  25                  30          


Gln Trp Ile Gly Asp Gly Ala Lys Arg Leu Gly Leu Glu Gly Lys Val 
        35                  40                  45              


Glu Ala Arg Ala Phe Asp Ala Leu Leu Arg Gly Glu Leu Pro Asp Gly 
    50                  55                  60                  


Ser Ser Val Gly Asn Pro Gly Gln Ala His Arg Pro Gly Thr Asp Leu 
65                  70                  75                  80  


Thr Phe Ser Val Pro Lys Ser Trp Ser Leu Leu Ala Leu Val Gly Lys 
                85                  90                  95      


Asp Glu Arg Ile Ile Ala Ala Tyr Arg Glu Ala Val Val Glu Ala Leu 
            100                 105                 110         


His Trp Ala Glu Lys Asn Ala Ala Glu Thr Arg Val Val Glu Lys Gly 
        115                 120                 125             


Met Val Val Thr Gln Ala Thr Gly Asn Leu Ala Ile Gly Leu Phe Gln 
    130                 135                 140                 


His Asp Thr Asn Arg Asn Gln Glu Pro Asn Leu His Phe His Ala Val 
145                 150                 155                 160 


Ile Ala Asn Val Thr Gln Gly Lys Asp Gly Lys Trp Arg Thr Leu Lys 
                165                 170                 175     


Asn Asp Arg Leu Trp Gln Leu Asn Thr Thr Leu Asn Ser Ile Ala Met 
            180                 185                 190         


Ala Arg Phe Arg Val Ala Val Glu Lys Leu Gly Tyr Glu Pro Gly Pro 
        195                 200                 205             


Val Leu Lys His Gly Asn Phe Glu Ala Arg Gly Ile Ser Arg Glu Gln 
    210                 215                 220                 


Val Met Ala Phe Ser Thr Arg Arg Lys Glu Val Leu Glu Ala Arg Arg 
225                 230                 235                 240 


Gly Pro Gly Leu Asp Ala Gly Arg Ile Ala Ala Leu Asp Thr Arg Ala 
                245                 250                 255     


Ser Lys Glu Gly Ile Glu Asp Arg Ala Thr Leu Ser Lys Gln Trp Ser 
            260                 265                 270         


Glu Ala Ala Gln Ser Ile Gly Leu Asp Leu Lys Pro Leu Val Asp Arg 
        275                 280                 285             


Ala Arg Thr Lys Ala Leu Gly Gln Gly Met Glu Ala Thr Arg Ile Gly 
    290                 295                 300                 


Ser Leu Val Glu Arg Gly Arg Ala Trp Leu Ser Arg Phe Ala Ala His 
305                 310                 315                 320 


Val Arg Gly Asp Pro Ala Asp Pro Leu Val Pro Pro Ser Val Leu Lys 
                325                 330                 335     


Gln Asp Arg Gln Thr Ile Ala Ala Ala Gln Ala Val Ala Ser Ala Val 
            340                 345                 350         


Arg His Leu Ser Gln Arg Glu Ala Ala Phe Glu Arg Thr Ala Leu Tyr 
        355                 360                 365             


Lys Ala Ala Leu Asp Phe Gly Leu Pro Thr Thr Ile Ala Asp Val Glu 
    370                 375                 380                 


Lys Arg Thr Arg Ala Leu Val Arg Ser Gly Asp Leu Ile Ala Gly Lys 
385                 390                 395                 400 


Gly Glu His Lys Gly Trp Leu Ala Ser Arg Asp Ala Val Val Thr Glu 
                405                 410                 415     


Gln Arg Ile Leu Ser Glu Val Ala Ala Gly Lys Gly Asp Ser Ser Pro 
            420                 425                 430         


Ala Ile Thr Pro Gln Lys Ala Ala Ala Ser Val Gln Ala Ala Ala Leu 
        435                 440                 445             


Thr Gly Gln Gly Phe Arg Leu Asn Glu Gly Gln Leu Ala Ala Ala Arg 
    450                 455                 460                 


Leu Ile Leu Ile Ser Lys Asp Arg Thr Ile Ala Val Gln Gly Ile Ala 
465                 470                 475                 480 


Gly Ala Gly Lys Ser Ser Val Leu Lys Pro Val Ala Glu Val Leu Arg 
                485                 490                 495     


Asp Glu Gly His Pro Val Ile Gly Leu Ala Ile Gln Asn Thr Leu Val 
            500                 505                 510         


Gln Met Leu Glu Arg Asp Thr Gly Ile Gly Ser Gln Thr Leu Ala Arg 
        515                 520                 525             


Phe Leu Gly Gly Trp Asn Lys Leu Leu Asp Asp Pro Gly Asn Val Ala 
    530                 535                 540                 


Leu Arg Ala Glu Ala Gln Ala Ser Leu Lys Asp His Val Leu Val Leu 
545                 550                 555                 560 


Asp Glu Ala Ser Met Val Ser Asn Glu Asp Lys Glu Lys Leu Val Arg 
                565                 570                 575     


Leu Ala Asn Leu Ala Gly Val His Arg Leu Val Leu Ile Gly Asp Arg 
            580                 585                 590         


Lys Gln Leu Gly Ala Val Asp Ala Gly Lys Pro Phe Ala Leu Leu Gln 
        595                 600                 605             


Arg Ala Gly Ile Ala Arg Ala Glu Met Ala Thr Asn Leu Arg Ala Arg 
    610                 615                 620                 


Asp Pro Val Val Arg Glu Ala Gln Ala Ala Ala Gln Ala Gly Asp Val 
625                 630                 635                 640 


Arg Lys Ala Leu Arg His Leu Lys Ser His Thr Val Glu Ala Arg Gly 
                645                 650                 655     


Asp Gly Ala Gln Val Ala Ala Glu Thr Trp Leu Ala Leu Asp Lys Glu 
            660                 665                 670         


Thr Arg Ala Arg Thr Ser Ile Tyr Ala Ser Gly Arg Ala Ile Arg Ser 
        675                 680                 685             


Ala Val Asn Ala Ala Val Gln Gln Gly Leu Leu Ala Ser Arg Glu Ile 
    690                 695                 700                 


Gly Pro Ala Lys Met Lys Leu Glu Val Leu Asp Arg Val Asn Thr Thr 
705                 710                 715                 720 


Arg Glu Glu Leu Arg His Leu Pro Ala Tyr Arg Ala Gly Arg Val Leu 
                725                 730                 735     


Glu Val Ser Arg Lys Gln Gln Ala Leu Gly Leu Phe Ile Gly Glu Tyr 
            740                 745                 750         


Arg Val Ile Gly Gln Asp Arg Lys Gly Lys Leu Val Glu Val Glu Asp 
        755                 760                 765             


Lys Arg Gly Lys Arg Phe Arg Phe Asp Pro Ala Arg Ile Arg Ala Gly 
    770                 775                 780                 


Lys Gly Asp Asp Asn Leu Thr Leu Leu Glu Pro Arg Lys Leu Glu Ile 
785                 790                 795                 800 


His Glu Gly Asp Arg Ile Arg Trp Thr Arg Asn Asp His Arg Arg Gly 
                805                 810                 815     


Leu Phe Asn Ala Asp Gln Ala Arg Val Val Glu Ile Ala Asn Gly Lys 
            820                 825                 830         


Val Thr Phe Glu Thr Ser Lys Gly Asp Leu Val Glu Leu Lys Lys Asp 
        835                 840                 845             


Asp Pro Met Leu Lys Arg Ile Asp Leu Ala Tyr Ala Leu Asn Val His 
    850                 855                 860                 


Met Ala Gln Gly Leu Thr Ser Asp Arg Gly Ile Ala Val Met Asp Ser 
865                 870                 875                 880 


Arg Glu Arg Asn Leu Ser Asn Gln Lys Thr Phe Leu Val Thr Val Thr 
                885                 890                 895     


Arg Leu Arg Asp His Leu Thr Leu Val Val Asp Ser Ala Asp Lys Leu 
            900                 905                 910         


Gly Ala Ala Val Ala Arg Asn Lys Gly Glu Lys Ala Ser Ala Ile Glu 
        915                 920                 925             


Val Thr Gly Ser Val Lys Pro Thr Ala Thr Lys Gly Ser Gly Val Asp 
    930                 935                 940                 


Gln Pro Lys Ser Val Glu Ala Asn Lys Ala Glu Lys Glu Leu Thr Arg 
945                 950                 955                 960 


Ser Lys Ser Lys Thr Leu Asp Phe Gly Ile 
                965                 970 


<210>  88
<211>  73
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide used in the Examples

<400>  88
tttttttttt tttttttttt tttttttttt tttttttttt ttttttggtt gtttctgttg       60

gtgctgatat tgc                                                          73


<210>  89
<211>  984
<212>  PRT
<213>  Methanopyrus kandleri

<400>  89

Met Ala Leu Val Tyr Asp Ala Glu Phe Val Gly Ser Glu Arg Glu Phe 
1               5                   10                  15      


Glu Glu Glu Arg Glu Thr Phe Leu Lys Gly Val Lys Ala Tyr Asp Gly 
            20                  25                  30          


Val Leu Ala Thr Arg Tyr Leu Met Glu Arg Ser Ser Ser Ala Lys Asn 
        35                  40                  45              


Asp Glu Glu Leu Leu Glu Leu His Gln Asn Phe Ile Leu Leu Thr Gly 
    50                  55                  60                  


Ser Tyr Ala Cys Ser Ile Asp Pro Thr Glu Asp Arg Tyr Gln Asn Val 
65                  70                  75                  80  


Ile Val Arg Gly Val Asn Phe Asp Glu Arg Val Gln Arg Leu Ser Thr 
                85                  90                  95      


Gly Gly Ser Pro Ala Arg Tyr Ala Ile Val Tyr Arg Arg Gly Trp Arg 
            100                 105                 110         


Ala Ile Ala Lys Ala Leu Asp Ile Asp Glu Glu Asp Val Pro Ala Ile 
        115                 120                 125             


Glu Val Arg Ala Val Lys Arg Asn Pro Leu Gln Pro Ala Leu Tyr Arg 
    130                 135                 140                 


Ile Leu Val Arg Tyr Gly Arg Val Asp Leu Met Pro Val Thr Val Asp 
145                 150                 155                 160 


Glu Val Pro Pro Glu Met Ala Gly Glu Phe Glu Arg Leu Ile Glu Arg 
                165                 170                 175     


Tyr Asp Val Pro Ile Asp Glu Lys Glu Glu Arg Ile Leu Glu Ile Leu 
            180                 185                 190         


Arg Glu Asn Pro Trp Thr Pro His Asp Glu Ile Ala Arg Arg Leu Gly 
        195                 200                 205             


Leu Ser Val Ser Glu Val Glu Gly Glu Lys Asp Pro Glu Ser Ser Gly 
    210                 215                 220                 


Ile Tyr Ser Leu Trp Ser Arg Val Val Val Asn Ile Glu Tyr Asp Glu 
225                 230                 235                 240 


Arg Thr Ala Lys Arg His Val Lys Arg Arg Asp Arg Leu Leu Glu Glu 
                245                 250                 255     


Leu Tyr Glu His Leu Glu Glu Leu Ser Glu Arg Tyr Leu Arg His Pro 
            260                 265                 270         


Leu Thr Arg Arg Trp Ile Val Glu His Lys Arg Asp Ile Met Arg Arg 
        275                 280                 285             


Tyr Leu Glu Gln Arg Ile Val Glu Cys Ala Leu Lys Leu Gln Asp Arg 
    290                 295                 300                 


Tyr Gly Ile Arg Glu Asp Val Ala Leu Cys Leu Ala Arg Ala Phe Asp 
305                 310                 315                 320 


Gly Ser Ile Ser Met Ile Ala Thr Thr Pro Tyr Arg Thr Leu Lys Asp 
                325                 330                 335     


Val Cys Pro Asp Leu Thr Leu Glu Glu Ala Lys Ser Val Asn Arg Thr 
            340                 345                 350         


Leu Ala Thr Leu Ile Asp Glu His Gly Leu Ser Pro Asp Ala Ala Asp 
        355                 360                 365             


Glu Leu Ile Glu His Phe Glu Ser Ile Ala Gly Ile Leu Ala Thr Asp 
    370                 375                 380                 


Leu Glu Glu Ile Glu Arg Met Tyr Glu Glu Gly Arg Leu Ser Glu Glu 
385                 390                 395                 400 


Ala Tyr Arg Ala Ala Val Glu Ile Gln Leu Ala Glu Leu Thr Lys Lys 
                405                 410                 415     


Glu Gly Val Gly Arg Lys Thr Ala Glu Arg Leu Leu Arg Ala Phe Gly 
            420                 425                 430         


Asn Pro Glu Arg Val Lys Gln Leu Ala Arg Glu Phe Glu Ile Glu Lys 
        435                 440                 445             


Leu Ala Ser Val Glu Gly Val Gly Glu Arg Val Leu Arg Ser Leu Val 
    450                 455                 460                 


Pro Gly Tyr Ala Ser Leu Ile Ser Ile Arg Gly Ile Asp Arg Glu Arg 
465                 470                 475                 480 


Ala Glu Arg Leu Leu Lys Lys Tyr Gly Gly Tyr Ser Lys Val Arg Glu 
                485                 490                 495     


Ala Gly Val Glu Glu Leu Arg Glu Asp Gly Leu Thr Asp Ala Gln Ile 
            500                 505                 510         


Arg Glu Leu Lys Gly Leu Lys Thr Leu Glu Ser Ile Val Gly Asp Leu 
        515                 520                 525             


Glu Lys Ala Asp Glu Leu Lys Arg Lys Tyr Gly Ser Ala Ser Ala Val 
    530                 535                 540                 


Arg Arg Leu Pro Val Glu Glu Leu Arg Glu Leu Gly Phe Ser Asp Asp 
545                 550                 555                 560 


Glu Ile Ala Glu Ile Lys Gly Ile Pro Lys Lys Leu Arg Glu Ala Phe 
                565                 570                 575     


Asp Leu Glu Thr Ala Ala Glu Leu Tyr Glu Arg Tyr Gly Ser Leu Lys 
            580                 585                 590         


Glu Ile Gly Arg Arg Leu Ser Tyr Asp Asp Leu Leu Glu Leu Gly Ala 
        595                 600                 605             


Thr Pro Lys Ala Ala Ala Glu Ile Lys Gly Pro Glu Phe Lys Phe Leu 
    610                 615                 620                 


Leu Asn Ile Glu Gly Val Gly Pro Lys Leu Ala Glu Arg Ile Leu Glu 
625                 630                 635                 640 


Ala Val Asp Tyr Asp Leu Glu Arg Leu Ala Ser Leu Asn Pro Glu Glu 
                645                 650                 655     


Leu Ala Glu Lys Val Glu Gly Leu Gly Glu Glu Leu Ala Glu Arg Val 
            660                 665                 670         


Val Tyr Ala Ala Arg Glu Arg Val Glu Ser Arg Arg Lys Ser Gly Arg 
        675                 680                 685             


Gln Glu Arg Ser Glu Glu Glu Trp Lys Glu Trp Leu Glu Arg Lys Val 
    690                 695                 700                 


Gly Glu Gly Arg Ala Arg Arg Leu Ile Glu Tyr Phe Gly Ser Ala Gly 
705                 710                 715                 720 


Glu Val Gly Lys Leu Val Glu Asn Ala Glu Val Ser Lys Leu Leu Glu 
                725                 730                 735     


Val Pro Gly Ile Gly Asp Glu Ala Val Ala Arg Leu Val Pro Gly Tyr 
            740                 745                 750         


Lys Thr Leu Arg Asp Ala Gly Leu Thr Pro Ala Glu Ala Glu Arg Val 
        755                 760                 765             


Leu Lys Arg Tyr Gly Ser Val Ser Lys Val Gln Glu Gly Ala Thr Pro 
    770                 775                 780                 


Asp Glu Leu Arg Glu Leu Gly Leu Gly Asp Ala Lys Ile Ala Arg Ile 
785                 790                 795                 800 


Leu Gly Leu Arg Ser Leu Val Asn Lys Arg Leu Asp Val Asp Thr Ala 
                805                 810                 815     


Tyr Glu Leu Lys Arg Arg Tyr Gly Ser Val Ser Ala Val Arg Lys Ala 
            820                 825                 830         


Pro Val Lys Glu Leu Arg Glu Leu Gly Leu Ser Asp Arg Lys Ile Ala 
        835                 840                 845             


Arg Ile Lys Gly Ile Pro Glu Thr Met Leu Gln Val Arg Gly Met Ser 
    850                 855                 860                 


Val Glu Lys Ala Glu Arg Leu Leu Glu Arg Phe Asp Thr Trp Thr Lys 
865                 870                 875                 880 


Val Lys Glu Ala Pro Val Ser Glu Leu Val Arg Val Pro Gly Val Gly 
                885                 890                 895     


Leu Ser Leu Val Lys Glu Ile Lys Ala Gln Val Asp Pro Ala Trp Lys 
            900                 905                 910         


Ala Leu Leu Asp Val Lys Gly Val Ser Pro Glu Leu Ala Asp Arg Leu 
        915                 920                 925             


Val Glu Glu Leu Gly Ser Pro Tyr Arg Val Leu Thr Ala Lys Lys Ser 
    930                 935                 940                 


Asp Leu Met Arg Val Glu Arg Val Gly Pro Lys Leu Ala Glu Arg Ile 
945                 950                 955                 960 


Arg Ala Ala Gly Lys Arg Tyr Val Glu Glu Arg Arg Ser Arg Arg Glu 
                965                 970                 975     


Arg Ile Arg Arg Lys Leu Arg Gly 
            980                 


<210>  90
<211>  1308
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TrwC Cba-TopoV Mka

<400>  90

Met Leu Ser Val Ala Asn Val Arg Ser Pro Ser Ala Ala Ala Ser Tyr 
1               5                   10                  15      


Phe Ala Ser Asp Asn Tyr Tyr Ala Ser Ala Asp Ala Asp Arg Ser Gly 
            20                  25                  30          


Gln Trp Ile Gly Asp Gly Ala Lys Arg Leu Gly Leu Glu Gly Lys Val 
        35                  40                  45              


Glu Ala Arg Ala Phe Asp Ala Leu Leu Arg Gly Glu Leu Pro Asp Gly 
    50                  55                  60                  


Ser Ser Val Gly Asn Pro Gly Gln Ala His Arg Pro Gly Thr Asp Leu 
65                  70                  75                  80  


Thr Phe Ser Val Pro Lys Ser Trp Ser Leu Leu Ala Leu Val Gly Lys 
                85                  90                  95      


Asp Glu Arg Ile Ile Ala Ala Tyr Arg Glu Ala Val Val Glu Ala Leu 
            100                 105                 110         


His Trp Ala Glu Lys Asn Ala Ala Glu Thr Arg Val Val Glu Lys Gly 
        115                 120                 125             


Met Val Val Thr Gln Ala Thr Gly Asn Leu Ala Ile Gly Leu Phe Gln 
    130                 135                 140                 


His Asp Thr Asn Arg Asn Gln Glu Pro Asn Leu His Phe His Ala Val 
145                 150                 155                 160 


Ile Ala Asn Val Thr Gln Gly Lys Asp Gly Lys Trp Arg Thr Leu Lys 
                165                 170                 175     


Asn Asp Arg Leu Trp Gln Leu Asn Thr Thr Leu Asn Ser Ile Ala Met 
            180                 185                 190         


Ala Arg Phe Arg Val Ala Val Glu Lys Leu Gly Tyr Glu Pro Gly Pro 
        195                 200                 205             


Val Leu Lys His Gly Asn Phe Glu Ala Arg Gly Ile Ser Arg Glu Gln 
    210                 215                 220                 


Val Met Ala Phe Ser Thr Arg Arg Lys Glu Val Leu Glu Ala Arg Arg 
225                 230                 235                 240 


Gly Pro Gly Leu Asp Ala Gly Arg Ile Ala Ala Leu Asp Thr Arg Ala 
                245                 250                 255     


Ser Lys Glu Gly Ile Glu Asp Arg Ala Thr Leu Ser Lys Gln Trp Ser 
            260                 265                 270         


Glu Ala Ala Gln Ser Ile Gly Leu Asp Leu Lys Pro Leu Val Asp Arg 
        275                 280                 285             


Ala Arg Thr Lys Ala Leu Gly Gln Gly Met Glu Ala Thr Arg Ile Gly 
    290                 295                 300                 


Ser Leu Val Glu Arg Gly Arg Ala Trp Leu Ser Arg Phe Ala Ala His 
305                 310                 315                 320 


Val Arg Gly Asp Pro Ala Asp Pro Leu Val Pro Pro Ser Val Leu Lys 
                325                 330                 335     


Gln Asp Arg Gln Thr Ile Ala Ala Ala Gln Ala Val Ala Ser Ala Val 
            340                 345                 350         


Arg His Leu Ser Gln Arg Glu Ala Ala Phe Glu Arg Thr Ala Leu Tyr 
        355                 360                 365             


Lys Ala Ala Leu Asp Phe Gly Leu Pro Thr Thr Ile Ala Asp Val Glu 
    370                 375                 380                 


Lys Arg Thr Arg Ala Leu Val Arg Ser Gly Asp Leu Ile Ala Gly Lys 
385                 390                 395                 400 


Gly Glu His Lys Gly Trp Leu Ala Ser Arg Asp Ala Val Val Thr Glu 
                405                 410                 415     


Gln Arg Ile Leu Ser Glu Val Ala Ala Gly Lys Gly Asp Ser Ser Pro 
            420                 425                 430         


Ala Ile Thr Pro Gln Lys Ala Ala Ala Ser Val Gln Ala Ala Ala Leu 
        435                 440                 445             


Thr Gly Gln Gly Phe Arg Leu Asn Glu Gly Gln Leu Ala Ala Ala Arg 
    450                 455                 460                 


Leu Ile Leu Ile Ser Lys Asp Arg Thr Ile Ala Val Gln Gly Ile Ala 
465                 470                 475                 480 


Gly Ala Gly Lys Ser Ser Val Leu Lys Pro Val Ala Glu Val Leu Arg 
                485                 490                 495     


Asp Glu Gly His Pro Val Ile Gly Leu Ala Ile Gln Asn Thr Leu Val 
            500                 505                 510         


Gln Met Leu Glu Arg Asp Thr Gly Ile Gly Ser Gln Thr Leu Ala Arg 
        515                 520                 525             


Phe Leu Gly Gly Trp Asn Lys Leu Leu Asp Asp Pro Gly Asn Val Ala 
    530                 535                 540                 


Leu Arg Ala Glu Ala Gln Ala Ser Leu Lys Asp His Val Leu Val Leu 
545                 550                 555                 560 


Asp Glu Ala Ser Met Val Ser Asn Glu Asp Lys Glu Lys Leu Val Arg 
                565                 570                 575     


Leu Ala Asn Leu Ala Gly Val His Arg Leu Val Leu Ile Gly Asp Arg 
            580                 585                 590         


Lys Gln Leu Gly Ala Val Asp Ala Gly Lys Pro Phe Ala Leu Leu Gln 
        595                 600                 605             


Arg Ala Gly Ile Ala Arg Ala Glu Met Ala Thr Asn Leu Arg Ala Arg 
    610                 615                 620                 


Asp Pro Val Val Arg Glu Ala Gln Ala Ala Ala Gln Ala Gly Asp Val 
625                 630                 635                 640 


Arg Lys Ala Leu Arg His Leu Lys Ser His Thr Val Glu Ala Arg Gly 
                645                 650                 655     


Asp Gly Ala Gln Val Ala Ala Glu Thr Trp Leu Ala Leu Asp Lys Glu 
            660                 665                 670         


Thr Arg Ala Arg Thr Ser Ile Tyr Ala Ser Gly Arg Ala Ile Arg Ser 
        675                 680                 685             


Ala Val Asn Ala Ala Val Gln Gln Gly Leu Leu Ala Ser Arg Glu Ile 
    690                 695                 700                 


Gly Pro Ala Lys Met Lys Leu Glu Val Leu Asp Arg Val Asn Thr Thr 
705                 710                 715                 720 


Arg Glu Glu Leu Arg His Leu Pro Ala Tyr Arg Ala Gly Arg Val Leu 
                725                 730                 735     


Glu Val Ser Arg Lys Gln Gln Ala Leu Gly Leu Phe Ile Gly Glu Tyr 
            740                 745                 750         


Arg Val Ile Gly Gln Asp Arg Lys Gly Lys Leu Val Glu Val Glu Asp 
        755                 760                 765             


Lys Arg Gly Lys Arg Phe Arg Phe Asp Pro Ala Arg Ile Arg Ala Gly 
    770                 775                 780                 


Lys Gly Asp Asp Asn Leu Thr Leu Leu Glu Pro Arg Lys Leu Glu Ile 
785                 790                 795                 800 


His Glu Gly Asp Arg Ile Arg Trp Thr Arg Asn Asp His Arg Arg Gly 
                805                 810                 815     


Leu Phe Asn Ala Asp Gln Ala Arg Val Val Glu Ile Ala Asn Gly Lys 
            820                 825                 830         


Val Thr Phe Glu Thr Ser Lys Gly Asp Leu Val Glu Leu Lys Lys Asp 
        835                 840                 845             


Asp Pro Met Leu Lys Arg Ile Asp Leu Ala Tyr Ala Leu Asn Val His 
    850                 855                 860                 


Met Ala Gln Gly Leu Thr Ser Asp Arg Gly Ile Ala Val Met Asp Ser 
865                 870                 875                 880 


Arg Glu Arg Asn Leu Ser Asn Gln Lys Thr Phe Leu Val Thr Val Thr 
                885                 890                 895     


Arg Leu Arg Asp His Leu Thr Leu Val Val Asp Ser Ala Asp Lys Leu 
            900                 905                 910         


Gly Ala Ala Val Ala Arg Asn Lys Gly Glu Lys Ala Ser Ala Ile Glu 
        915                 920                 925             


Val Thr Gly Ser Val Lys Pro Thr Ala Thr Lys Gly Ser Gly Val Asp 
    930                 935                 940                 


Gln Pro Lys Ser Val Glu Ala Asn Lys Ala Glu Lys Glu Leu Thr Arg 
945                 950                 955                 960 


Ser Lys Ser Lys Thr Leu Asp Phe Gly Ile Ala Tyr Asp Val Gly Ala 
                965                 970                 975     


Ser Gly Arg Gln Glu Arg Ser Glu Glu Glu Trp Lys Glu Trp Leu Glu 
            980                 985                 990         


Arg Lys Val Gly Glu Gly Arg Ala  Arg Arg Leu Ile Glu  Tyr Phe Gly 
        995                 1000                 1005             


Ser Ala  Gly Glu Val Gly Lys  Leu Val Glu Asn Ala  Glu Val Ser 
    1010                 1015                 1020             


Lys Leu  Leu Glu Val Pro Gly  Ile Gly Asp Glu Ala  Val Ala Arg 
    1025                 1030                 1035             


Leu Val  Pro Gly Tyr Lys Thr  Leu Arg Asp Ala Gly  Leu Thr Pro 
    1040                 1045                 1050             


Ala Glu  Ala Glu Arg Val Leu  Lys Arg Tyr Gly Ser  Val Ser Lys 
    1055                 1060                 1065             


Val Gln  Glu Gly Ala Thr Pro  Asp Glu Leu Arg Glu  Leu Gly Leu 
    1070                 1075                 1080             


Gly Asp  Ala Lys Ile Ala Arg  Ile Leu Gly Leu Arg  Ser Leu Val 
    1085                 1090                 1095             


Asn Lys  Arg Leu Asp Val Asp  Thr Ala Tyr Glu Leu  Lys Arg Arg 
    1100                 1105                 1110             


Tyr Gly  Ser Val Ser Ala Val  Arg Lys Ala Pro Val  Lys Glu Leu 
    1115                 1120                 1125             


Arg Glu  Leu Gly Leu Ser Asp  Arg Lys Ile Ala Arg  Ile Lys Gly 
    1130                 1135                 1140             


Ile Pro  Glu Thr Met Leu Gln  Val Arg Gly Met Ser  Val Glu Lys 
    1145                 1150                 1155             


Ala Glu  Arg Leu Leu Glu Arg  Phe Asp Thr Trp Thr  Lys Val Lys 
    1160                 1165                 1170             


Glu Ala  Pro Val Ser Glu Leu  Val Arg Val Pro Gly  Val Gly Leu 
    1175                 1180                 1185             


Ser Leu  Val Lys Glu Ile Lys  Ala Gln Val Asp Pro  Ala Trp Lys 
    1190                 1195                 1200             


Ala Leu  Leu Asp Val Lys Gly  Val Ser Pro Glu Leu  Ala Asp Arg 
    1205                 1210                 1215             


Leu Val  Glu Glu Leu Gly Ser  Pro Tyr Arg Val Leu  Thr Ala Lys 
    1220                 1225                 1230             


Lys Ser  Asp Leu Met Arg Val  Glu Arg Val Gly Pro  Lys Leu Ala 
    1235                 1240                 1245             


Glu Arg  Ile Arg Ala Ala Gly  Lys Arg Tyr Val Glu  Glu Arg Arg 
    1250                 1255                 1260             


Ser Arg  Arg Glu Arg Ile Arg  Arg Lys Leu Arg Gly  Ser Gly Gly 
    1265                 1270                 1275             


Ser Ala  Trp Ser His Pro Gln  Phe Glu Lys Gly Gly  Gly Ser Gly 
    1280                 1285                 1290             


Gly Gly  Ser Gly Gly Ser Ala  Trp Ser His Pro Gln  Phe Glu Lys 
    1295                 1300                 1305             


<210>  91
<211>  88
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide used in the Examples

<400>  91
cgtggtcacg aggagctcgt cctcacctcg acgtctgcac gagctttttt tttttttttt       60

tttttttttt tttttttttt tttttttt                                          88


<210>  92
<211>  88
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide used in the Examples

<400>  92
tttttttttt tttttttttt tttttttttt tttttttttt ttttgctcgt gcagacgtcg       60

aggtgaggac gagctcctcg tgaccacg                                          88


<210>  93
<211>  44
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide used in the Examples

<400>  93
cgtggtcacg aggagctcgt cctcacctcg acgtctgcac gagc                        44


<210>  94
<211>  299
<212>  PRT
<213>  Methanopyrus kandleri

<400>  94

Ser Gly Arg Gln Glu Arg Ser Glu Glu Glu Trp Lys Glu Trp Leu Glu 
1               5                   10                  15      


Arg Lys Val Gly Glu Gly Arg Ala Arg Arg Leu Ile Glu Tyr Phe Gly 
            20                  25                  30          


Ser Ala Gly Glu Val Gly Lys Leu Val Glu Asn Ala Glu Val Ser Lys 
        35                  40                  45              


Leu Leu Glu Val Pro Gly Ile Gly Asp Glu Ala Val Ala Arg Leu Val 
    50                  55                  60                  


Pro Gly Tyr Lys Thr Leu Arg Asp Ala Gly Leu Thr Pro Ala Glu Ala 
65                  70                  75                  80  


Glu Arg Val Leu Lys Arg Tyr Gly Ser Val Ser Lys Val Gln Glu Gly 
                85                  90                  95      


Ala Thr Pro Asp Glu Leu Arg Glu Leu Gly Leu Gly Asp Ala Lys Ile 
            100                 105                 110         


Ala Arg Ile Leu Gly Leu Arg Ser Leu Val Asn Lys Arg Leu Asp Val 
        115                 120                 125             


Asp Thr Ala Tyr Glu Leu Lys Arg Arg Tyr Gly Ser Val Ser Ala Val 
    130                 135                 140                 


Arg Lys Ala Pro Val Lys Glu Leu Arg Glu Leu Gly Leu Ser Asp Arg 
145                 150                 155                 160 


Lys Ile Ala Arg Ile Lys Gly Ile Pro Glu Thr Met Leu Gln Val Arg 
                165                 170                 175     


Gly Met Ser Val Glu Lys Ala Glu Arg Leu Leu Glu Arg Phe Asp Thr 
            180                 185                 190         


Trp Thr Lys Val Lys Glu Ala Pro Val Ser Glu Leu Val Arg Val Pro 
        195                 200                 205             


Gly Val Gly Leu Ser Leu Val Lys Glu Ile Lys Ala Gln Val Asp Pro 
    210                 215                 220                 


Ala Trp Lys Ala Leu Leu Asp Val Lys Gly Val Ser Pro Glu Leu Ala 
225                 230                 235                 240 


Asp Arg Leu Val Glu Glu Leu Gly Ser Pro Tyr Arg Val Leu Thr Ala 
                245                 250                 255     


Lys Lys Ser Asp Leu Met Arg Val Glu Arg Val Gly Pro Lys Leu Ala 
            260                 265                 270         


Glu Arg Ile Arg Ala Ala Gly Lys Arg Tyr Val Glu Glu Arg Arg Ser 
        275                 280                 285             


Arg Arg Glu Arg Ile Arg Arg Lys Leu Arg Gly 
    290                 295                 


<210>  95
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RecD-like motif I of TrwC Cba

<400>  95

Gly Ile Ala Gly Ala Gly Lys Ser 
1               5               


<210>  96
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RecD-like motif V of TrwC Cba

<400>  96

Tyr Ala Leu Asn Val His Met Ala Gln Gly 
1               5                   10  


<210>  97
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobF motif III of TrwC Cba

<400>  97

His Asp Thr Asn Arg Asn Gln Glu Pro Asn Leu His Phe His 
1               5                   10                  


<210>  98
<211>  943
<212>  PRT
<213>  Halothiobacillus neapolitanus c2

<400>  98

Met Leu Arg Ile Lys Asn Leu Lys Gly Asp Pro Ser Ala Ile Ile Asp 
1               5                   10                  15      


Tyr Ala Glu Asn Lys Lys Asn His Pro Asp Gln Lys Ser Gly Tyr Tyr 
            20                  25                  30          


Asp Ala Lys Gly Ala Pro Ser Ala Trp Gly Gly Ala Leu Ala Ala Asp 
        35                  40                  45              


Leu Gly Leu Ser Gly Ser Val Gln Ala Ala Asp Leu Lys Lys Leu Leu 
    50                  55                  60                  


Ser Gly Glu Leu Ser Asp Gly Thr Arg Phe Ala Lys Glu Asp Pro Asp 
65                  70                  75                  80  


Arg Arg Leu Gly Ile Asp Met Ser Phe Ser Ala Pro Lys Ser Val Ser 
                85                  90                  95      


Leu Ala Ala Leu Val Gly Gly Asp Glu Arg Ile Ile Gln Ala His Asp 
            100                 105                 110         


Ala Ala Val Arg Thr Ala Met Ser Met Ile Glu Gln Glu Tyr Ala Thr 
        115                 120                 125             


Ala Arg Phe Gly His Ala Gly Arg Asn Val Val Cys Ser Gly Lys Leu 
    130                 135                 140                 


Val Tyr Ala Ala Tyr Arg His Glu Asp Ala Arg Thr Val Asp Asp Ile 
145                 150                 155                 160 


Ala Asp Pro Gln Leu His Thr His Cys Ile Val Ser Asn Ile Thr Ile 
                165                 170                 175     


Asp Pro Glu Thr Gly Lys Pro Arg Ser Ile Asp Phe Ala Trp Gly Gln 
            180                 185                 190         


Asp Gly Ile Lys Leu Ala Gly Ala Met Tyr Arg Ala Glu Leu Ala Arg 
        195                 200                 205             


Arg Leu Lys Glu Met Gly Tyr Glu Leu Arg Lys Ser Glu Glu Gly Phe 
    210                 215                 220                 


Glu Leu Ala Gln Ile Ser Asp Glu Gln Val Glu Thr Phe Ser Arg Arg 
225                 230                 235                 240 


Arg Val Gln Val Asp Gln Ala Leu Glu Gln Gln Gly Thr Asp Arg Glu 
                245                 250                 255     


His Ala Ser Ser Glu Leu Lys Thr Ala Val Thr Leu Ala Thr Arg Gln 
            260                 265                 270         


Gly Lys Ala Gln Leu Ser Ala Glu Asp Gln Tyr Glu Glu Trp Gln Gln 
        275                 280                 285             


Arg Ala Ala Glu Ala Glu Leu Asp Leu Ser Gln Pro Val Gly Pro Arg 
    290                 295                 300                 


Val Ser Val Thr Pro Pro Glu Ile Asp Leu Asp His Thr Phe Glu His 
305                 310                 315                 320 


Leu Ser Glu Arg Ala Ser Val Ile Asn Lys Asp Ala Val Arg Leu Asp 
                325                 330                 335     


Ala Leu Ile Asn His Met Ser Glu Gly Ala Thr Leu Ser Thr Val Asp 
            340                 345                 350         


Lys Ala Ile Gln Gly Ala Ala Val Thr Gly Asp Val Phe Glu Ile Glu 
        355                 360                 365             


Asp Gly Ile Lys Arg Lys Ile Ile Thr Arg Glu Thr Leu Lys Arg Glu 
    370                 375                 380                 


Gln Gln Ile Leu Leu Leu Ala Gln Gln Gly Arg Gly Val Asn Ser Val 
385                 390                 395                 400 


Leu Ile Gly Val Gly Asp Thr Lys His Leu Ile Glu Asp Ala Glu Gln 
                405                 410                 415     


Ala Gln Gly Phe Arg Phe Ser Glu Gly Gln Arg Arg Ala Ile Asn Leu 
            420                 425                 430         


Thr Ala Thr Thr Thr Asp Gln Val Ser Gly Ile Val Gly Ala Ala Gly 
        435                 440                 445             


Ala Gly Lys Thr Thr Ala Met Lys Thr Val Ala Asp Leu Ala Lys Ser 
    450                 455                 460                 


Gln Gly Leu Thr Val Val Gly Ile Ala Pro Ser Ser Ala Ala Ala Asp 
465                 470                 475                 480 


Glu Leu Lys Ser Ala Gly Ala Asp Asp Thr Met Thr Leu Ala Thr Phe 
                485                 490                 495     


Asn Leu Lys Gly Glu Ala Ala Gly Pro Arg Leu Leu Ile Leu Asp Glu 
            500                 505                 510         


Ala Gly Met Val Ser Ala Arg Asp Gly Glu Ala Leu Leu Lys Lys Leu 
        515                 520                 525             


Gly Lys Glu Asp Arg Leu Ile Phe Val Gly Asp Pro Lys Gln Leu Ala 
    530                 535                 540                 


Ala Val Glu Ala Gly Ser Pro Phe Ala Gln Leu Met Arg Ser Gly Ala 
545                 550                 555                 560 


Ile Gln Tyr Ala Glu Ile Thr Glu Ile Asn Arg Gln Lys Asp Gln Lys 
                565                 570                 575     


Leu Leu Asp Ile Ala Gln His Phe Ala Lys Gly Lys Ala Glu Glu Ala 
            580                 585                 590         


Val Ala Leu Ala Thr Lys Tyr Val Thr Glu Val Pro Val Thr Leu Pro 
        595                 600                 605             


Asp Lys Pro Glu His Lys Ile Thr Arg Gln Ala Lys Thr Glu Ala Arg 
    610                 615                 620                 


Arg Leu Ala Ile Ala Ser Ala Thr Ala Lys Arg Tyr Leu Glu Leu Ser 
625                 630                 635                 640 


Gln Glu Glu Arg Ala Thr Thr Leu Val Leu Ser Gly Thr Asn Ala Val 
                645                 650                 655     


Arg Lys Gln Val Asn Glu Gln Val Arg Lys Gly Leu Ile Asp Lys Gly 
            660                 665                 670         


Glu Ile Asn Gly Glu Ser Phe Thr Val Ser Thr Leu Asp Lys Ala Asp 
        675                 680                 685             


Met Thr Arg Ala Lys Met Arg Lys Ala Gly Asn Tyr Lys Pro Gly Gln 
    690                 695                 700                 


Val Ile Lys Thr Ala Gly Lys Gln Ala Glu Gln Ser Glu Val Val Ala 
705                 710                 715                 720 


Val Asn Leu Asp Gln Asn Leu Ile Gln Val Lys Leu Ser Asp Gly Thr 
                725                 730                 735     


Leu Lys Ser Ile Asp Ala Ser Arg Phe Asp Val Lys Lys Thr Gln Val 
            740                 745                 750         


Phe Asn Pro Arg Gln Ile Asp Ile Ala Ala Gly Asp Lys Ile Ile Phe 
        755                 760                 765             


Thr Asn Asn Asp Gln Ala Thr Glu Thr Lys Asn Asn Gln Ile Gly Leu 
    770                 775                 780                 


Ile Glu Glu Ile Lys Asp Gly Lys Ala Ile Ile Asn Ser Asn Gly Ala 
785                 790                 795                 800 


Lys Val Glu Ile Asp Ile Gln Arg Lys Leu His Ile Asp His Ala Tyr 
                805                 810                 815     


Cys Ile Thr Ile His Arg Ser Gln Gly Gln Thr Val Asp Ser Val Ile 
            820                 825                 830         


Val Ala Gly Glu Ala Ser Arg Thr Thr Thr Ala Glu Ala Ala Tyr Val 
        835                 840                 845             


Ala Cys Thr Arg Glu Arg Tyr Lys Leu Glu Ile Ile Thr Asp Asn Thr 
    850                 855                 860                 


Glu Arg Leu Ser Lys Asn Trp Val Arg Tyr Ala Asp Arg Gln Thr Ala 
865                 870                 875                 880 


Ala Glu Ala Leu Lys Ser Ser Glu Glu Lys Tyr Pro His Leu Asp Glu 
                885                 890                 895     


Ile Arg Glu Glu Leu Arg Arg Glu Leu Gln Gln Glu Leu Glu Arg Gln 
            900                 905                 910         


Glu Pro Thr Asn Ile Thr Pro Glu Leu Glu Ile Glu Met Glu Arg Ser 
        915                 920                 925             


Met Phe Asp Gln Tyr Thr Leu His Ser Arg Gln Pro Arg Ser Tyr 
    930                 935                 940             


<210>  99
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RecD-like motif I of TrwC Hne

<400>  99

Gly Ala Ala Gly Ala Gly Lys Thr 
1               5               


<210>  100
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RecD-like motif V of TrwC Hne

<400>  100

Tyr Cys Ile Thr Ile His Arg Ser Gln Gly 
1               5                   10  


<210>  101
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobF motif III of TrwC Hne

<400>  101

His Glu Asp Ala Arg Thr Val Asp Asp Ile Ala Asp Pro Gln Leu His 
1               5                   10                  15      


Thr His 
        


<210>  102
<211>  960
<212>  PRT
<213>  Erythrobacter litoralis HTCC2594

<400>  102

Met Leu Ser Val Ala Asn Val Arg Ser Pro Thr Ala Ala Ala Ser Tyr 
1               5                   10                  15      


Phe Ala Ser Asp Asn Tyr Tyr Ala Ser Ala Asp Ala Asp Arg Ser Gly 
            20                  25                  30          


Gln Trp Ile Gly Gly Gly Ala Lys Arg Leu Gly Leu Glu Gly Lys Val 
        35                  40                  45              


Glu Ala Lys Ala Phe Asp Ala Leu Leu Arg Gly Glu Leu Pro Asp Gly 
    50                  55                  60                  


Ser Ser Val Gly Asn Pro Gly Gln Ala His Arg Pro Gly Thr Asp Leu 
65                  70                  75                  80  


Ser Phe Ser Val Pro Lys Ser Trp Ser Leu Leu Ala Leu Val Gly Lys 
                85                  90                  95      


Asp Glu Arg Ile Ile Ala Ala Tyr Arg Glu Ala Val Val Glu Ala Leu 
            100                 105                 110         


Gln Trp Ala Glu Lys Asn Ala Ala Glu Thr Arg Ile Val Glu Lys Gly 
        115                 120                 125             


Lys Met Val Thr Gln Ala Thr Gly Asn Leu Ala Val Gly Leu Phe Gln 
    130                 135                 140                 


His Asp Thr Asn Arg Asn Gln Glu Pro Asn Leu His Phe His Ala Val 
145                 150                 155                 160 


Ile Ala Asn Val Thr Gln Gly Lys Asp Gly Lys Trp Arg Thr Leu Lys 
                165                 170                 175     


Asn Asp Arg Leu Trp Gln Leu Asn Thr Thr Leu Asn Ser Ile Ala Met 
            180                 185                 190         


Ala Arg Phe Arg Val Ala Val Glu Lys Leu Gly Tyr Glu Pro Gly Pro 
        195                 200                 205             


Val Leu Lys His Gly Asn Phe Glu Ala Arg Gly Ile Ser Arg Glu Gln 
    210                 215                 220                 


Ile Met Ala Phe Ser Thr Arg Arg Lys Glu Val Leu Glu Ala Arg Arg 
225                 230                 235                 240 


Gly Pro Gly Leu Glu Ala Gly Arg Ile Ala Ala Leu Asp Thr Arg Ala 
                245                 250                 255     


Ser Lys Glu Glu Ile Glu Asp Arg Ala Thr Leu Gly Lys Gln Trp Ser 
            260                 265                 270         


Glu Thr Ala Gln Ser Ile Gly Leu Asp Leu Thr Pro Leu Val Asp Arg 
        275                 280                 285             


Ala Arg Thr Asn Ala Leu Gly Gln Ser Met Glu Ala Thr Arg Ile Gly 
    290                 295                 300                 


Ser Leu Val Glu Arg Gly Arg Ala Trp Leu Ser Arg Phe Ala Ala His 
305                 310                 315                 320 


Val Arg Gly Asp Pro Ala Asp Pro Leu Val Pro Pro Ser Val Leu Lys 
                325                 330                 335     


Gln Asp Arg Gln Thr Ile Ala Ala Ala Gln Ala Val Ala Ser Ala Ile 
            340                 345                 350         


Arg His Leu Ser Gln Arg Glu Ala Ala Phe Glu Arg Thr Ala Leu Tyr 
        355                 360                 365             


Lys Ala Ala Leu Asp Phe Gly Leu Pro Ala Thr Ile Ala Asp Val Glu 
    370                 375                 380                 


Lys Arg Thr Arg Ala Leu Val Arg Ser Gly Asp Leu Ile Ser Gly Lys 
385                 390                 395                 400 


Gly Glu His Lys Gly Trp Leu Ala Ser Arg Glu Ala Val Val Thr Glu 
                405                 410                 415     


Gln Arg Ile Leu Ser Glu Val Ala Ala Gly Lys Gly Asn Ser Ser Pro 
            420                 425                 430         


Ala Ile Glu Pro Gln Lys Ala Ala Ala Ser Val Gln Ala Ala Ala Ala 
        435                 440                 445             


Thr Gly Gln Gly Phe Arg Leu Asn Glu Gly Gln Leu Ala Ala Ala Glu 
    450                 455                 460                 


Leu Ile Leu Thr Ser Lys Asp Arg Thr Ile Ala Ile Gln Gly Ile Ala 
465                 470                 475                 480 


Gly Ala Gly Lys Ser Ser Val Leu Lys Pro Val Ala Glu Val Leu Arg 
                485                 490                 495     


Asp Glu Gly His Pro Val Ile Gly Leu Ala Ile Gln Asn Thr Leu Val 
            500                 505                 510         


Gln Met Leu Glu Arg Glu Thr Gly Ile Gly Ser Gln Thr Leu Ala Arg 
        515                 520                 525             


Phe Leu Arg Gly Trp Thr Lys Leu Leu Gly Asp Pro Gly Asn Val Ala 
    530                 535                 540                 


Leu Arg Thr Glu Ala Gln Ala Ser Leu Lys Asp His Val Leu Val Leu 
545                 550                 555                 560 


Asp Glu Ala Ser Met Val Ser Asn Glu Asp Lys Glu Lys Leu Val Arg 
                565                 570                 575     


Leu Ala Asn Leu Ala Gly Val His Arg Leu Val Leu Ile Gly Asp Arg 
            580                 585                 590         


Lys Gln Leu Gly Ala Val Asp Ala Gly Lys Pro Phe Ala Leu Leu Gln 
        595                 600                 605             


Arg Ala Gly Ile Ala Arg Ala Glu Met Ala Thr Asn Leu Arg Ala Arg 
    610                 615                 620                 


Asp Pro Val Val Arg Glu Ala Gln Ala Ser Ala Gln Ala Gly Asp Val 
625                 630                 635                 640 


Arg Asn Ala Leu Arg His Leu Lys Ser His Thr Val Glu Ala Lys Gly 
                645                 650                 655     


Asp Gly Ala Gln Val Ala Ala Glu Thr Trp Leu Ala Leu Asp Lys Glu 
            660                 665                 670         


Thr Arg Ala Arg Thr Ser Ile Tyr Ala Ser Gly Arg Ala Ile Arg Ser 
        675                 680                 685             


Ala Val Asn Ala Ala Val Gln Gln Gly Leu Leu Ala Asn Arg Glu Ile 
    690                 695                 700                 


Gly Pro Gly Met Met Lys Leu Asp Val Leu Asp Arg Val Asn Ala Thr 
705                 710                 715                 720 


Arg Glu Glu Leu Arg His Leu Pro Ala Tyr Arg Ala Gly Gln Val Leu 
                725                 730                 735     


Glu Ile Ser Arg Lys Gln Gln Ala Leu Gly Leu Ser Val Gly Glu Tyr 
            740                 745                 750         


Arg Val Leu Gly Gln Asp Arg Lys Gly Arg Leu Val Glu Val Glu Asp 
        755                 760                 765             


Lys Arg Gly Lys Arg Phe Arg Phe Asp Pro Ala Arg Ile Lys Ala Gly 
    770                 775                 780                 


Lys Gly Asp Glu Asn Leu Thr Leu Leu Glu Pro Arg Lys Leu Glu Ile 
785                 790                 795                 800 


His Glu Gly Asp Arg Ile Arg Trp Thr Arg Asn Asp His Arg Arg Gly 
                805                 810                 815     


Leu Phe Asn Ala Asp Gln Ala Arg Val Val Ala Ile Ala Gly Gly Lys 
            820                 825                 830         


Ile Thr Phe Glu Thr Ser Gln Gly Asp Gln Val Glu Leu Lys Arg Asp 
        835                 840                 845             


Asp Pro Met Leu Lys Arg Ile Asp Leu Ala Tyr Ala Leu Asn Ala His 
    850                 855                 860                 


Met Ala Gln Gly Leu Thr Ser Asp Arg Gly Ile Ala Val Met Thr Ser 
865                 870                 875                 880 


Ser Glu Arg Asn Leu Ser Asn Gln Lys Thr Phe Met Val Thr Val Thr 
                885                 890                 895     


Arg Leu Arg Asp His Leu Thr Leu Val Val Asp Asn Ala Glu Lys Leu 
            900                 905                 910         


Gly Ala Ala Val Ala Arg Asn Lys Gly Glu Lys Ala Ser Ala Leu Glu 
        915                 920                 925             


Val Thr Gly Ser Val Lys Ser Thr Ala Ala Lys Gly Ser Gly Val Asp 
    930                 935                 940                 


Gln Leu Lys Pro Glu Glu Ala Asn Lys Ala Glu Lys Glu Leu Thr Arg 
945                 950                 955                 960 


<210>  103
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RecD-like motif V of TrwC Eli

<400>  103

Tyr Ala Leu Asn Ala His Met Ala Gln Gly 
1               5                   10  


<210>  104
<211>  606
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide used in the Examples

<400>  104
gccatcagat tgtgtttgtt agtcgctttt tttttttgga attttttttt tggaattttt       60

tttttgacgc tcagtaatgt gacgatagct gaaaactgta cgataaacgg tacgctgagg      120

gcggaaaaaa tcgtcgggga cattgtaaag gcggcgagcg cggcttttcc gcgccagcgt      180

gaaagcagtg tggactggcc gtcaggtacc cgtactgtca ccgtgaccga tgaccatcct      240

tttgatcgcc agatagtggt gcttccgctg acgtttcgcg gaagtaagcg tactgtcagc      300

ggcaggacaa cgtattcgat gtgttatctg aaagtactga tgaacggtgc ggtgatttat      360

gatggcgcgg cgaacgaggc ggtacaggtg ttctcccgta ttgttgacat gccagcgggt      420

cggggaaacg tgatcctgac gttcacgctt acgtccacac ggcattcggc agatattccg      480

ccgtatacgt ttgccagcga tgtgcaggtt atggtgatta agaaacaggc gctgggcatc      540

agcgtggtct gagtgtgaaa aaaaaggtac caaaaaaaac atcgtcgtga gtagtgaacc      600

gtaagc                                                                 606


<210>  105
<211>  853
<212>  PRT
<213>  Escherichia coli

<400>  105

Met Ser Ala Ile Glu Asn Phe Asp Ala His Thr Pro Met Met Gln Gln 
1               5                   10                  15      


Tyr Leu Arg Leu Lys Ala Gln His Pro Glu Ile Leu Leu Phe Tyr Arg 
            20                  25                  30          


Met Gly Asp Phe Tyr Glu Leu Phe Tyr Asp Asp Ala Lys Arg Ala Ser 
        35                  40                  45              


Gln Leu Leu Asp Ile Ser Leu Thr Lys Arg Gly Ala Ser Ala Gly Glu 
    50                  55                  60                  


Pro Ile Pro Met Ala Gly Ile Pro Tyr His Ala Val Glu Asn Tyr Leu 
65                  70                  75                  80  


Ala Lys Leu Val Asn Gln Gly Glu Ser Val Ala Ile Cys Glu Gln Ile 
                85                  90                  95      


Gly Asp Pro Ala Thr Ser Lys Gly Pro Val Glu Arg Lys Val Val Arg 
            100                 105                 110         


Ile Val Thr Pro Gly Thr Ile Ser Asp Glu Ala Leu Leu Gln Glu Arg 
        115                 120                 125             


Gln Asp Asn Leu Leu Ala Ala Ile Trp Gln Asp Ser Lys Gly Phe Gly 
    130                 135                 140                 


Tyr Ala Thr Leu Asp Ile Ser Ser Gly Arg Phe Arg Leu Ser Glu Pro 
145                 150                 155                 160 


Ala Asp Arg Glu Thr Met Ala Ala Glu Leu Gln Arg Thr Asn Pro Ala 
                165                 170                 175     


Glu Leu Leu Tyr Ala Glu Asp Phe Ala Glu Met Ser Leu Ile Glu Gly 
            180                 185                 190         


Arg Arg Gly Leu Arg Arg Arg Pro Leu Trp Glu Phe Glu Ile Asp Thr 
        195                 200                 205             


Ala Arg Gln Gln Leu Asn Leu Gln Phe Gly Thr Arg Asp Leu Val Gly 
    210                 215                 220                 


Phe Gly Val Glu Asn Ala Pro Arg Gly Leu Cys Ala Ala Gly Cys Leu 
225                 230                 235                 240 


Leu Gln Tyr Ala Lys Asp Thr Gln Arg Thr Thr Leu Pro His Ile Arg 
                245                 250                 255     


Ser Ile Thr Met Glu Arg Glu Gln Asp Ser Ile Ile Met Asp Ala Ala 
            260                 265                 270         


Thr Arg Arg Asn Leu Glu Ile Thr Gln Asn Leu Ala Gly Gly Ala Glu 
        275                 280                 285             


Asn Thr Leu Ala Ser Val Leu Asp Cys Thr Val Thr Pro Met Gly Ser 
    290                 295                 300                 


Arg Met Leu Lys Arg Trp Leu His Met Pro Val Arg Asp Thr Arg Val 
305                 310                 315                 320 


Leu Leu Glu Arg Gln Gln Thr Ile Gly Ala Leu Gln Asp Phe Thr Ala 
                325                 330                 335     


Gly Leu Gln Pro Val Leu Arg Gln Val Gly Asp Leu Glu Arg Ile Leu 
            340                 345                 350         


Ala Arg Leu Ala Leu Arg Thr Ala Arg Pro Arg Asp Leu Ala Arg Met 
        355                 360                 365             


Arg His Ala Phe Gln Gln Leu Pro Glu Leu Arg Ala Gln Leu Glu Thr 
    370                 375                 380                 


Val Asp Ser Ala Pro Val Gln Ala Leu Arg Glu Lys Met Gly Glu Phe 
385                 390                 395                 400 


Ala Glu Leu Arg Asp Leu Leu Glu Arg Ala Ile Ile Asp Thr Pro Pro 
                405                 410                 415     


Val Leu Val Arg Asp Gly Gly Val Ile Ala Ser Gly Tyr Asn Glu Glu 
            420                 425                 430         


Leu Asp Glu Trp Arg Ala Leu Ala Asp Gly Ala Thr Asp Tyr Leu Glu 
        435                 440                 445             


Arg Leu Glu Val Arg Glu Arg Glu Arg Thr Gly Leu Asp Thr Leu Lys 
    450                 455                 460                 


Val Gly Phe Asn Ala Val His Gly Tyr Tyr Ile Gln Ile Ser Arg Gly 
465                 470                 475                 480 


Gln Ser His Leu Ala Pro Ile Asn Tyr Met Arg Arg Gln Thr Leu Lys 
                485                 490                 495     


Asn Ala Glu Arg Tyr Ile Ile Pro Glu Leu Lys Glu Tyr Glu Asp Lys 
            500                 505                 510         


Val Leu Thr Ser Lys Gly Lys Ala Leu Ala Leu Glu Lys Gln Leu Tyr 
        515                 520                 525             


Glu Glu Leu Phe Asp Leu Leu Leu Pro His Leu Glu Ala Leu Gln Gln 
    530                 535                 540                 


Ser Ala Ser Ala Leu Ala Glu Leu Asp Val Leu Val Asn Leu Ala Glu 
545                 550                 555                 560 


Arg Ala Tyr Thr Leu Asn Tyr Thr Cys Pro Thr Phe Ile Asp Lys Pro 
                565                 570                 575     


Gly Ile Arg Ile Thr Glu Gly Arg His Pro Val Val Glu Gln Val Leu 
            580                 585                 590         


Asn Glu Pro Phe Ile Ala Asn Pro Leu Asn Leu Ser Pro Gln Arg Arg 
        595                 600                 605             


Met Leu Ile Ile Thr Gly Pro Asn Met Gly Gly Lys Ser Thr Tyr Met 
    610                 615                 620                 


Arg Gln Thr Ala Leu Ile Ala Leu Met Ala Tyr Ile Gly Ser Tyr Val 
625                 630                 635                 640 


Pro Ala Gln Lys Val Glu Ile Gly Pro Ile Asp Arg Ile Phe Thr Arg 
                645                 650                 655     


Val Gly Ala Ala Asp Asp Leu Ala Ser Gly Arg Ser Thr Phe Met Val 
            660                 665                 670         


Glu Met Thr Glu Thr Ala Asn Ile Leu His Asn Ala Thr Glu Tyr Ser 
        675                 680                 685             


Leu Val Leu Met Asp Glu Ile Gly Arg Gly Thr Ser Thr Tyr Asp Gly 
    690                 695                 700                 


Leu Ser Leu Ala Trp Ala Cys Ala Glu Asn Leu Ala Asn Lys Ile Lys 
705                 710                 715                 720 


Ala Leu Thr Leu Phe Ala Thr His Tyr Phe Glu Leu Thr Gln Leu Pro 
                725                 730                 735     


Glu Lys Met Glu Gly Val Ala Asn Val His Leu Asp Ala Leu Glu His 
            740                 745                 750         


Gly Asp Thr Ile Ala Phe Met His Ser Val Gln Asp Gly Ala Ala Ser 
        755                 760                 765             


Lys Ser Tyr Gly Leu Ala Val Ala Ala Leu Ala Gly Val Pro Lys Glu 
    770                 775                 780                 


Val Ile Lys Arg Ala Arg Gln Lys Leu Arg Glu Leu Glu Ser Ile Ser 
785                 790                 795                 800 


Pro Asn Ala Ala Ala Thr Gln Val Asp Gly Thr Gln Met Ser Leu Leu 
                805                 810                 815     


Ser Val Pro Glu Glu Thr Ser Pro Ala Val Glu Ala Leu Glu Asn Leu 
            820                 825                 830         


Asp Pro Asp Ser Leu Thr Pro Arg Gln Ala Leu Glu Trp Ile Tyr Arg 
        835                 840                 845             


Leu Lys Ser Leu Val 
    850             


<210>  106
<211>  64
<212>  PRT
<213>  Sulfolobus solfataricus

<400>  106

Met Ala Thr Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Ile Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Ile Ser Phe 
            20                  25                  30          


Thr Tyr Asp Glu Gly Gly Gly Lys Thr Gly Arg Gly Ala Val Ser Glu 
        35                  40                  45              


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Lys Lys 
    50                  55                  60                  


<210>  107
<211>  99
<212>  PRT
<213>  Sulfolobus solfataricus

<400>  107

Glu Lys Met Ser Ser Gly Thr Pro Thr Pro Ser Asn Val Val Leu Ile 
1               5                   10                  15      


Gly Lys Lys Pro Val Met Asn Tyr Val Leu Ala Ala Leu Thr Leu Leu 
            20                  25                  30          


Asn Gln Gly Val Ser Glu Ile Val Ile Lys Ala Arg Gly Arg Ala Ile 
        35                  40                  45              


Ser Lys Ala Val Asp Thr Val Glu Ile Val Arg Asn Arg Phe Leu Pro 
    50                  55                  60                  


Asp Lys Ile Glu Ile Lys Glu Ile Arg Val Gly Ser Gln Val Val Thr 
65                  70                  75                  80  


Ser Gln Asp Gly Arg Gln Ser Arg Val Ser Thr Ile Glu Ile Ala Ile 
                85                  90                  95      


Arg Lys Lys 
            


<210>  108
<211>  88
<212>  PRT
<213>  Sulfolobus solfataricus

<400>  108

Thr Glu Lys Leu Asn Glu Ile Val Val Arg Lys Thr Lys Asn Val Glu 
1               5                   10                  15      


Asp His Val Leu Asp Val Ile Val Leu Phe Asn Gln Gly Ile Asp Glu 
            20                  25                  30          


Val Ile Leu Lys Gly Thr Gly Arg Glu Ile Ser Lys Ala Val Asp Val 
        35                  40                  45              


Tyr Asn Ser Leu Lys Asp Arg Leu Gly Asp Gly Val Gln Leu Val Asn 
    50                  55                  60                  


Val Gln Thr Gly Ser Glu Val Arg Asp Arg Arg Arg Ile Ser Tyr Ile 
65                  70                  75                  80  


Leu Leu Arg Leu Lys Arg Val Tyr 
                85              


<210>  109
<211>  107
<212>  PRT
<213>  Escherichia coli

<400>  109

Ala Gln Gln Ser Pro Tyr Ser Ala Ala Met Ala Glu Gln Arg His Gln 
1               5                   10                  15      


Glu Trp Leu Arg Phe Val Asp Leu Leu Lys Asn Ala Tyr Gln Asn Asp 
            20                  25                  30          


Leu His Leu Pro Leu Leu Asn Leu Met Leu Thr Pro Asp Glu Arg Glu 
        35                  40                  45              


Ala Leu Gly Thr Arg Val Arg Ile Val Glu Glu Leu Leu Arg Gly Glu 
    50                  55                  60                  


Met Ser Gln Arg Glu Leu Lys Asn Glu Leu Gly Ala Gly Ile Ala Thr 
65                  70                  75                  80  


Ile Thr Arg Gly Ser Asn Ser Leu Lys Ala Ala Pro Val Glu Leu Arg 
                85                  90                  95      


Gln Trp Leu Glu Glu Val Leu Leu Lys Ser Asp 
            100                 105         


<210>  110
<211>  237
<212>  PRT
<213>  Bacteriophage lambda

<400>  110

Met Ser Thr Lys Lys Lys Pro Leu Thr Gln Glu Gln Leu Glu Asp Ala 
1               5                   10                  15      


Arg Arg Leu Lys Ala Ile Tyr Glu Lys Lys Lys Asn Glu Leu Gly Leu 
            20                  25                  30          


Ser Gln Glu Ser Val Ala Asp Lys Met Gly Met Gly Gln Ser Gly Val 
        35                  40                  45              


Gly Ala Leu Phe Asn Gly Ile Asn Ala Leu Asn Ala Tyr Asn Ala Ala 
    50                  55                  60                  


Leu Leu Ala Lys Ile Leu Lys Val Ser Val Glu Glu Phe Ser Pro Ser 
65                  70                  75                  80  


Ile Ala Arg Glu Ile Tyr Glu Met Tyr Glu Ala Val Ser Met Gln Pro 
                85                  90                  95      


Ser Leu Arg Ser Glu Tyr Glu Tyr Pro Val Phe Ser His Val Gln Ala 
            100                 105                 110         


Gly Met Phe Ser Pro Glu Leu Arg Thr Phe Thr Lys Gly Asp Ala Glu 
        115                 120                 125             


Arg Trp Val Ser Thr Thr Lys Lys Ala Ser Asp Ser Ala Phe Trp Leu 
    130                 135                 140                 


Glu Val Glu Gly Asn Ser Met Thr Ala Pro Thr Gly Ser Lys Pro Ser 
145                 150                 155                 160 


Phe Pro Asp Gly Met Leu Ile Leu Val Asp Pro Glu Gln Ala Val Glu 
                165                 170                 175     


Pro Gly Asp Phe Cys Ile Ala Arg Leu Gly Gly Asp Glu Phe Thr Phe 
            180                 185                 190         


Lys Lys Leu Ile Arg Asp Ser Gly Gln Val Phe Leu Gln Pro Leu Asn 
        195                 200                 205             


Pro Gln Tyr Pro Met Ile Pro Cys Asn Glu Ser Cys Ser Val Val Gly 
    210                 215                 220                 


Lys Val Ile Ala Ser Gln Trp Pro Glu Glu Thr Phe Gly 
225                 230                 235         


<210>  111
<211>  60
<212>  PRT
<213>  Crenarchaea

<400>  111

Met Ser Ser Gly Lys Lys Pro Val Lys Val Lys Thr Pro Ala Gly Lys 
1               5                   10                  15      


Glu Ala Glu Leu Val Pro Glu Lys Val Trp Ala Leu Ala Pro Lys Gly 
            20                  25                  30          


Arg Lys Gly Val Lys Ile Gly Leu Phe Lys Asp Pro Glu Thr Gly Lys 
        35                  40                  45              


Tyr Phe Arg His Lys Leu Pro Asp Asp Tyr Pro Ile 
    50                  55                  60  


<210>  112
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Ser Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  113
<211>  89
<212>  PRT
<213>  Bacteriophage T4

<400>  113

Met Ala Lys Lys Glu Met Val Glu Phe Asp Glu Ala Ile His Gly Glu 
1               5                   10                  15      


Asp Leu Ala Lys Phe Ile Lys Glu Ala Ser Asp His Lys Leu Lys Ile 
            20                  25                  30          


Ser Gly Tyr Asn Glu Leu Ile Lys Asp Ile Arg Ile Arg Ala Lys Asp 
        35                  40                  45              


Glu Leu Gly Val Asp Gly Lys Met Phe Asn Arg Leu Leu Ala Leu Tyr 
    50                  55                  60                  


His Lys Asp Asn Arg Asp Val Phe Glu Ala Glu Thr Glu Glu Val Val 
65                  70                  75                  80  


Glu Leu Tyr Asp Thr Val Phe Ser Lys 
                85                  


<210>  114
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Phe His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Ala Glu Ala Ala Lys 
65                  70                  75                  80  


Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg Arg 
                85                  90                  95      


Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys Leu 
            100                 105                 110         


Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly Glu 
        115                 120                 125             


Phe Arg Thr Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr Cys 
    130                 135                 140                 


Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr Ile 
145                 150                 155                 160 


Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala Glu 
                165                 170                 175     


Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr Ala 
            180                 185                 190         


Arg Ala Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala Ser 
        195                 200                 205             


Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser Ala 
    210                 215                 220                 


Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser Ala 
225                 230                 235                 240 


Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu Ala 
                245                 250                 255     


Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala Gln 
            260                 265                 270         


Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile Gly 
        275                 280                 285             


Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg Lys 
    290                 295                 300                 


Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys Leu 
305                 310                 315                 320 


Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly Asp 
                325                 330                 335     


Ala Lys Asp 
            


<210>  115
<211>  375
<212>  PRT
<213>  Citromicrobium bathyomarinum JL354

<400>  115

Met Lys Ala Thr Ile Glu Arg Ala Thr Leu Leu Arg Cys Leu Ser His 
1               5                   10                  15      


Val Gln Ser Val Val Glu Arg Arg Asn Thr Ile Pro Ile Leu Ser Asn 
            20                  25                  30          


Val Leu Ile Asp Ala Asp Ala Gly Gly Gly Val Lys Val Met Ala Thr 
        35                  40                  45              


Asp Leu Asp Leu Gln Val Val Glu Thr Met Thr Ala Ala Ser Val Glu 
    50                  55                  60                  


Ser Ala Gly Ala Ile Thr Val Ser Ala His Leu Leu Phe Asp Ile Ala 
65                  70                  75                  80  


Arg Lys Leu Pro Asp Gly Ser Gln Val Ser Leu Glu Thr Ala Asp Asn 
                85                  90                  95      


Arg Met Val Val Lys Ala Gly Arg Ser Arg Phe Gln Leu Pro Thr Leu 
            100                 105                 110         


Pro Arg Asp Asp Phe Pro Val Ile Val Glu Gly Glu Leu Pro Thr Ser 
        115                 120                 125             


Phe Glu Leu Pro Ala Arg Glu Leu Ala Glu Met Ile Asp Arg Thr Arg 
    130                 135                 140                 


Phe Ala Ile Ser Thr Glu Glu Thr Arg Tyr Tyr Leu Asn Gly Ile Phe 
145                 150                 155                 160 


Leu His Val Ser Asp Glu Ala Arg Pro Val Leu Lys Ala Ala Ala Thr 
                165                 170                 175     


Asp Gly His Arg Leu Ala Arg Tyr Thr Leu Asp Arg Pro Glu Gly Ala 
            180                 185                 190         


Glu Gly Met Pro Asp Val Ile Val Pro Arg Lys Ala Val Gly Glu Leu 
        195                 200                 205             


Arg Lys Leu Leu Glu Glu Ala Leu Asp Ser Asn Val Gln Ile Asp Leu 
    210                 215                 220                 


Ser Ala Ser Lys Ile Arg Phe Ala Leu Gly Gly Glu Gly Gly Val Val 
225                 230                 235                 240 


Leu Thr Ser Lys Leu Ile Asp Gly Thr Phe Pro Asp Tyr Ser Arg Val 
                245                 250                 255     


Ile Pro Thr Gly Asn Asp Lys Leu Leu Arg Leu Asp Pro Lys Ala Phe 
            260                 265                 270         


Phe Gln Gly Val Asp Arg Val Ala Thr Ile Ala Thr Glu Lys Thr Arg 
        275                 280                 285             


Ala Val Lys Met Gly Leu Asp Glu Asp Lys Val Thr Leu Ser Val Thr 
    290                 295                 300                 


Ser Pro Asp Asn Gly Thr Ala Ala Glu Glu Ile Ala Ala Glu Tyr Lys 
305                 310                 315                 320 


Ala Glu Gly Phe Glu Ile Gly Phe Asn Ala Asn Tyr Leu Lys Asp Ile 
                325                 330                 335     


Leu Gly Gln Ile Asp Ser Asp Thr Val Glu Leu His Leu Ala Asp Ala 
            340                 345                 350         


Gly Ala Pro Thr Leu Ile Arg Arg Asp Glu Asn Ser Pro Ala Leu Tyr 
        355                 360                 365             


Val Leu Met Pro Met Arg Val 
    370                 375 


