                         SEQUENCE LISTING

<110>  DSM IP Assets B.V.
 
<120>  AgsE-deficient strain

<130>  28995-WO-PCT

<150>  EP12177172.9
<151>  2012-07-19

<150>  US61/673596
<151>  2012-07-19

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  12018
<212>  DNA
<213>  Aspergillus niger


<220>
<221>  misc_feature
<223>  AgsE genomic DNA including 2kb upstream and downstream flanking 
       regions

<400>  1
tttcatttct ttgcctttct tttctttttt accaattttt ccctctttgc agttggaggc       60

ccgaaatcaa cgccacggaa gttggcggat tgatgatgat tgggataata ctgttggccc      120

caaaaataca cacacagaca cacacatacc atattcagga acaaacacac caccaaaccc      180

gctgcatgca tgggatggct cacctccccc ttctgcgagt tacgggcagc agataatgta      240

tacgtctgat cctttacacc agacgaacta aagtatacaa aaaaaaaaac gactaccgga      300

ctaccaccac ccctattacg gtatcacaac catcaacttc tctcaagtcg tatactacta      360

gtagactagt caaatcccgg tccctccgcc accaatcggg agggtccgtc cttatcagac      420

ccaaaatttc ctcccaaaaa aattgagaga aaacgagcaa cttgatgaca gtaagacatc      480

acctgcacta ttgtgtagag tgtcttagaa gagggccaat aaagtttttt cgttaccgag      540

attggctgca cgccaccgta ttgctgcctc ttcaggtatc gtttcgcttg ggcgtgaata      600

cgatctggct gattgattgt attggccccg aaaatacctt tagaagcagc agcagcagca      660

gcagaagggg tctgttgctt tacctctttc ccatggcacg gatataggcg atgggaacaa      720

taaggaagtc ctcggagggg ccacgaaggg tccagtcttc ggggggggct taaaagggag      780

ggactatatc ttaatgggga ttggtgaggg cctggcggta tcaagtgggc ggaaagaacc      840

cttctttcaa gacatccagt gatccagtcc aactgcccct tgggctccac cttaaactgc      900

tttccggtcc gagaggaaac ctaactaacg gctcccgaat agcctactta ctatacgaga      960

attggctcat atttttccat aggatggctg tcggaccacc caatggtccg cttccgttat     1020

tcatattttt tttttattca ctcttgtcca ttctgaattt tcaatttttc atttcatact     1080

tatttttaaa ttcccctttt ggactttgca ccgcactgcc gcggtctagt cctcttctga     1140

gcaggcaaaa agtattccgt catagccaaa gggaaccgcc cctcccactc gctctggaca     1200

aggctagagt ccctccggcg tggcttcgat atctttctta cccggggaac aattcctata     1260

cgagtgagct ggcaccggga agccattcag agtggttctc cagtcagctt gggggttatt     1320

attagcaaaa tacacataga cgagacaaga cgagacgtct agtctgcttc tgtttctttt     1380

ttttcatttc atcgtttctc ccctccctcg atccactatc gcggatatcg atgttgtgcc     1440

ccccccagtc cagcctctca ttgctgagcc tcagcatcgc tgctagctaa ttaccttact     1500

agttggagtg tgattagctt ttttctccat ttggatttct tgcctttgtt ccccatcatc     1560

tcccctctga cactttctct tcctcctatt cctcgtatca tctttcctct ctctctctct     1620

ctctttctct cttccacttt ctcctctctc gcttgatccc tcttatctct gatctcatgc     1680

atcgtttctt gttttagttg ttgttgcatt gtgattcccc atagatttca ctcgttaacg     1740

aagcgtgcct gtgtttctct cgttatctgc accctatcta tcgctcgtta tcagtcccat     1800

ctatccactc aaccgactat cattgagtga cctgcacccc cagcgaagag agatcgcaat     1860

caatctggtg acgagtcaga acccattctt tcccctccag tctttggcga actccataac     1920

cgcatcgatc tggctcaacg ttgtgttcct ggtttgttga ccggtggtca tcccgggtcg     1980

ccgcgacctt cccacccagc atgaagtggg ctatttccgg cacgctgctc gcctgtttcg     2040

caacaactgc aacggcctgg ccttacgacg agtccctcgt cgactacaac ttcaatcaga     2100

accagtccgc tacgaacccg gcggactatt ggggaacatg gcccaatcat accggggact     2160

acttcccctc cccggacaat tggcgcttcc ccgtctacac cctctttctc gaccgcttcg     2220

tcaacggtga ccccacaaac gacaacatca atggcaccct gttcgaacat gacctccgct     2280

cgaatcagat gcgccatggt ggcgatgttg ccggcctgct ggataccttg gattacttgc     2340

agggcatggg aatcaaggtc ggtccctgtg gcttgtccga tgctgcgatc aattactgac     2400

gatggtttag ggtctctatc ttgccggaac aatcctcatg aaccagccct ggggatctga     2460

cggttattcg gctttggaca cgacattgtt ggatcaacac tatggtaacc tgcagacgtg     2520

gcgcaatgcc atcacggaaa ttcacaagcg cgggatgtat gtcatcttcg ataacaccat     2580

cgcaacgtaa gtttgccgct gccttttccc ctctttccta cccaacaaac taacctgcaa     2640

tttttaggat gggtgatttg atcggatttg atggctatct gaacaccacc acccccttct     2700

ccgtgaagga acaccaaacg gtgtggaaga ctgaccgccg ctatgtggac ttcgacattg     2760

gcaatgacta caacgagacg tgcgactacc cccgcttctg gttcgaggat ggctaccccg     2820

ttcaagcgtc agtcaccgag gagcttgtcg gatgttacaa cagtgatttc gaccagtacg     2880

gtgatattga ggcctttggt gtcttccccg attggcaacg tcagctggca aaattcgcct     2940

ccgttcagga tcgactccgt gaatgggttc cctccgtgcg cgagcgtttg atccgccact     3000

cctgcatcat tattcagtcg ctcgatattg acggtttccg gtacgacaag gcgactcagg     3060

caaccgtcga cgccctcgga gatatgtcca atgcgtaccg cgagtgcgcc cgcgccgtag     3120

gaaaagagaa cttcttcatt gcgggcgaaa tcacgggtgg taataccttt ggttccatct     3180

acttgggccg aggaagacag cccaaccagt tccctgactc ggcggaggca gccatgaagc     3240

tgaccaacac ttccgacgcc cagtatttcc tgcgtgaagt gggacatgag gcgattgatg     3300

gtgcagcctt ccactactcc atttaccgag cgctgacccg cttcctgggc atggatggta     3360

acttggctgc cggttacgat gtgccagtcg actgggttga tgcctggaat ctcatgctgc     3420

agtccaacga tctggtcaat gcgaatacag gcaagttcga cccccgccac atgtacgggg     3480

ctaccaacca ggatgtcttc cgttggccca cggtggaaaa gggcgtggag cgtcagttgc     3540

ttggattgta catcacgact cttctgctcc ccggaattcc gctccttctc tggggcgagg     3600

aacaggcgtt ttacgtactg gatgccacgg catcgaacta catctacggt cggcaggcca     3660

tgtctcctgc caccgcatgg agggatcatg gctgtttctc cttggaatcg tctcagtact     3720

ataattggcc cattgagtcc ggccgtcagg gctgccacga ccccacggtg gcctacgatc     3780

atcgtgaccc gtctcatccc gtgcgcaata tcattaagca tatgtatcag atgcgcgaac     3840

agttccccgt cctcaatgac ggctatacta ttcaaaagct ctcgaaccac accgaggacg     3900

tgtactatct cggttccaac ggcacagcca ccgagaccgg actctggtcg attcttcgtg     3960

atgtgaacgc ggatgtgcag gatttgggct ccgatgcgaa gaaccagcct gtctggctgg     4020

tttaccacaa cacgaaccgc accattgatt acaagtttga ctgctcggat aatgatacag     4080

ctctgattgc ccccttcgat agtggcacct gggtcaaaaa cctgttccac ccgtatgacg     4140

agcaccagct gatcgattcc cccaccaagt tgggattgaa cggatcaact gcatacagtg     4200

gctgcttggc taatatgacc atgtccgcct atgaattccg ggcctacgtg cctaaaaccc     4260

gctttactaa acccaggccg atgattacaa agttcactcc gggacacgat gtcccgatcc     4320

gctcgaccgt ggccccgaac gcagacgaga acgtggaggt cgaaatttac ttctccgaag     4380

aaatggattg cgactcggtg acaaagtcca ttaccctttc gtcatcgacc gaaattggaa     4440

aggccccctc tgtcgattct ggcagtgtca actgcaagtc agtccccgcc actaacacca     4500

gctggaccgg ccagattccc ggggtgtgga tgtgggcggc caacctgaca ggtgtgtaca     4560

acggcattca tcgtctcaca gtcaacaatg tcagcacaga gagtgggaac gcaaccacca     4620

acgccgtcga ccatttcctc ttccgcatcg gccagattga taatccgatg attttcagca     4680

gtgcgaacta ttcaactagt ttgctccata aggaatccaa cggcaccctt ttcatccagc     4740

accacgccgc gggtgctgat aagtatcgct attctacgaa ttggggtacc actttctccg     4800

attggattga ctacaggggc ggaaatgaca ctattgagga actcgaatgg tcgggaacca     4860

agaagcagtc atggaaagga aaccacgttc gcgtggagta ttggagtcgt tggaccggca     4920

gcagcgatta cgtccaagag ggagacgcgg gctggaacga gaatgttcca cgccgtttcc     4980

ctcacgtctt cttcaacgga ccctacaacc agtatgggta tgatgcaggt ctggacaacg     5040

tggtccgcca ggacagcgtt gacggtctct ggaaatatca tttcaccgcg gaatggcctg     5100

ctcaagctca attgaacatt tggggtatga accctgatgg ggagcctgac cagagttggg     5160

tcctgggaga tgccgataat gattcggttc tcgatcgcat gccgccctct tcgctgtccg     5220

cgacattgat taacatcact gaacaccccc cctctcccta catttcgtgg aatatcttca     5280

ttgatgacgg gaccatgcgc ttccagctgt tccccgtcgg gcatcagaat actcagatcg     5340

ccatgtatgt gctcttttgg atcatccccg tcatcacggg cgcagccggt gtgtgggctt     5400

tcatgaagtc tttctacaag gtcaaattca accaggttgg tgtgagcgaa aaacaccaga     5460

tgatcccatt ggccttgcgg cggaagttca agcgcaatcg caatcgtggc ggtgatgagg     5520

aaaactcaaa ccctctcatg cgtctggcga acaagtccgg gttcctccag actgacacgg     5580

cgattggtgg tgctgctagc ggcaagcgtc gcatggtcct gatcgccacc atggagtacg     5640

acattgagga ttgggccatc aagatcaaga ttggtggtct tggtgtcatg gcgcaactca     5700

tgggtaagac tctgggtcat caagacttga tctgggtggt gccttgcgtt gggggtgtcg     5760

attaccccgt ggacaaaccc gcagagccca tgcatgtcac cattcttggc aattcgtacg     5820

aggtccaggt ccagtatcac gtcttgaata acatcaccta tgttctgctg gatgcccctg     5880

tgttccgtca acagtctaag tcagagcctt acccggctcg catggacgac ctgaacagcg     5940

ccatttacta ctcggcctgg aatcagtgca ttgcggaagc ctgcaagaga ttccctatcg     6000

acctgtatca tatcaacgac taccatggtt ccctggctcc actgtatcta cttcctgaca     6060

cagtacctgc ctgtctttcc ctgcataacg ccgagttcca aggtttgtgg cccatgcgga     6120

cgcagaaaga aaaggaggaa gtttgctccg tgttcaatct ggatatcgag accgtgaggc     6180

attacgtgca gtttggagag gtgttcaact tgctccactc gggtgctagt tatctccgtg     6240

ttcaccaaca aggtttcggt gctgttggtg tgtctaagaa gtacggaaag cggtcctacg     6300

cgcgttaccc cattttctgg ggtctccgca aggttggaaa cctacctaac cctgatccgt     6360

ctgatgtcgg tgagtggagc aaggaacagg ccagcgccat gggtgacaat gtgagcgtgg     6420

acccgactta tgaagccggt cgaggcgacc tcaagcgtca agctcaggag tgggccggtc     6480

ttgaacagaa ccctgacgcc gatttgcttg tcttcgttgg tcgttggtcg atgcagaagg     6540

gtgttgattt gatcgccgac gtcatgcctg ctgtcctgga agcacgcccc aatgttcagc     6600

tcatttgtgt tggaccagtt atcgatctct acggtaaatt cgcggccctc aaactcgatc     6660

acatgatgaa ggtctacccc ggacgagtgt tctctagacc tgagttcacg gcattgcccc     6720

cctacatctt ctctggtgct gaattcgcgc tgattccctc tcgtgacgag cccttcggtc     6780

tggtcgccgt cgagttcgga cgtaagggag ctctgggtat cggtgcccgg gttggtggtc     6840

tcggtcagat gccaggttgg tggtacaatg tggaatcgac agctacctcc catttgctcg     6900

ttcagttcaa gctggctatc gacgcggctc tcagttcgaa aacggaaact cgtgctatga     6960

tgcgtgcccg gtccgccaaa cagcgcttcc cggtcgccca gtgggtggaa gacttggaga     7020

tcctgcaaac caccgccatc caagtgcaca acaaggaatt ggttaaacat aacggtcgac     7080

ccttcacccc gtctggaact accacgccgg gtggcatctt aagccagccg tcaagtccac     7140

taatgccccc tggaatgcag actcccttgg ctcattctcg ggaaagcagc tattctaacc     7200

tgaaccgtct cagtgaatat gtcacagatc cgaaaacaaa ctacagtcga gacatcagcc     7260

ccagtgggac ggaaaagccg cggtccggcc tgcaacgaca gctttctctt ggtgttcgct     7320

caggacctgg tcatcaagag cgccgtggcc gtcgtggacg ccagcgcgac agcatccccg     7380

aacacgaaga caccgcaggg gccatgaccg acgtcgaaga agaccacgag gacattgggg     7440

atcagcagga tgcggacgac gagtacactc tcaccccggc tcaggtcgag gaaggacgtc     7500

gcttgcaggc tgtccagcag cagggagtgg gtatgccgac gagtccgggc gtccgccgtt     7560

atagtcaaga ctccttgcat ccgcgacagc ttcctagcag ccctggcccc gtcccacctc     7620

ctacacagag cctccttccg ccacccaggc ttggggatgc cggtagccga ctcagtagcg     7680

cgtctgtcct gtccctggat tcggtcgttg gtaccaagac ggacttcaag ctccagaagg     7740

ttgacccctt ctttacggat tctactggcg agtactacaa ggcattcgac aagaggctgg     7800

tcggcttgaa cggctcgaac tccgaatccc agctttgcat tgaggaatat ctcatcaaga     7860

gtgagaagga atggttcgac aagttccgcg atgcccgact gggtcgtcta aaatcccccg     7920

cgtcgtctgt cttccgggac aagcatggtg cctcccctgt tggctcctac tacgatgata     7980

cgggctcccg ggtgagtggt gactatgacc gggagtcccg cgacacggaa gatgacgagt     8040

tcctcctggg caaggactac gtgcctccga cgggtctgcg caagtggatg cagattcgtg     8100

ttggagactg gccagtctac tcgttattcc ttgccttggg tcagatcatt gcagccaact     8160

cttatcaggt gaccttgctt accggtgagg ttggtgagac ggccgagaag ctctatggta     8220

tcgcaaccac ctacctgatc acctcgatcc tttggtggct tgtgttccgt tacttcaaat     8280

cggtggtgtg cctctcggct ccctggttct tctatggcct tgccttcctt ctgatcggct     8340

ccgctcactt tgaacccaat tcattcaacc ggggttggat ccagaacatc ggaagtggat     8400

gttacgccgc tgcctcgtct agcggttcca tcttcttcgc cttgaacttt ggtgacgaag     8460

gtggtgcgcc ggtcgaaacc tggatcttcc gggcttgtct cattcagggt atccagtcgg     8520

cttatatcat cggactgtgg tattggggtt ccactctgac caaggcatcc agccagggtc     8580

tgttgacctc gacgaacaac atcgccaata gctggaagat gacgtgagta cattgaaccc     8640

tctgattgtt catcaatcag ccagtcattc catcttgtga cccgctaaca ctgatctcct     8700

ctagtgccat ctgttacccg attgcaatct tcctctgggc tgttggattg ctgcttctct     8760

ttggacttcc taactactat cgccaaaccc cgggcaaagt ggcctccttt tacaagtccg     8820

tattccgccg caagatcgtc ctctggaact tcgttgccgt catcctgcaa aacttcttcc     8880

tcagcgcacc gtacggccgc aactggggct gtaagtctaa ctttccctgc cacatcgtgt     8940

cgaattgata agctaactct agtccgcagt cctttggtct tccaatcacg ccaaggcctg     9000

gcaaatcgtt attctctgta tcgtcttcta cgggttcgtc tgggcgggct tcctgttcgt     9060

cgtcagccgc tatttcaagt cccacagctg gttcctgccc gtgtttgcgt gcggacttgg     9120

agcacctcgc ttcattcaaa tctggtgggg tgtctcgggc atcggttact tccttccctg     9180

ggtctccgga ggctatctcg gcggagcttt ggcctcgagg agtctctggc tctggctggg     9240

cgtgttggat tccatccagg gtctcgggtt cggtatcatc ctcctgcaga ccctcacccg     9300

catgcacatg ctgttcaccc tgatctgctc gcaggtgctt ggttccattg ccaccatctg     9360

tgcgcgggcg tttgccccga ataacgtcgg gcccggccct gtgtcgccgg accctacctt     9420

tggaggaagt gcagtggcca atgcgtggtt ctgggtggcc ctgttttgtc agctgttggt     9480

gtgtgctggc ttcctcctct tcttccggaa agagcagctt tccaaacctt gaacgcctta     9540

atgatgtggt ggtgcgcttg ggcaccaccg ggcatgaaca tttaacatac gtcccaccat     9600

tccttccttc cttccctccc tacctacgcc ccttggatat aattttactg tctgtcataa     9660

tataatctct cctgtatgta tatagaagtt cgcattacga tctgaatgat gtccaggtcg     9720

ttctcagcca atacaatttt gggattggaa aaaatccctg cagattcatc tgctgtcaat     9780

atcttccacc gcgtgatagt gttcaaaagg tttcaatgta gatggtatat tgtctaaaga     9840

gtacttgaga gataggctgt agtcgatcac ctgggttggg tgcagattag tgaggacggc     9900

tatgcctgcg ataacccagt acgtactcga ttgctgcctc aggtcccaat acttacccag     9960

ggaacaccaa aatacaataa atactttgta acagaattat aataataacc ttcaataagt    10020

atgaaataat aataatcgaa aagggaataa gagattagtc aaaaagaaaa ggaaaaaaaa    10080

aaaaaaaagg aaaccaaaat ccgaaaggca atcccgaagc aactcccgct tcggccggaa    10140

ctatccctga tcgggacaac cgggggctcc accgcggtcc ttccgggcga ggcagacgaa    10200

ctaataatat tgagaatgcg ggagggagtg ggaagttaga gagcgagaga cactctggaa    10260

caggagttcc cccctccctc tcttctctct tctctctctt cttctcttca tcttcttact    10320

tccgtctact ttcttcctca ctgctactat tgattccttg actccacacc taacactgct    10380

gtccccatca cacacataca tacatacact gcttttcttc attaactcta ttgatcatct    10440

acgatgaggc atcttgctac ttgatgagct catcgctctt accatgatgg aagaaatgga    10500

agttgaaaga tgaaaatgca tcgacattgg ctgacactcg cggttcgctg aatacaataa    10560

caagaacgaa acaacagatg gactgaaccc gacccgaacc ccaatctgaa acgaaactcc    10620

ttcccttctt cctcctaaac atccgtcttg aacgatgtga gccgcgcctt gattgcctcc    10680

tccgactcgt cggtatccaa ctcccgaaga acaccgcttc caacatcata aatcaacccg    10740

tgaacctgca acccacgctc ctggatcgct tccaacacca cgctcttctc cttcaacagc    10800

ttgacaccct ccaagacatt cagctcgacc agcttgaggt tcgcctggtc agccggcagc    10860

gagttcagca gatccaggtt cttcgcccgg agctggcgca ggggaagcaa ccaggggtcc    10920

aggattccca actgcttgtt acccagggca gcagcaacac cgccgcagct ggtgtgaccg    10980

cagaggacta catggttgac gcgcaggtaa cggaccgcgt actcgatcac ggcagacgag    11040

ctgaggtcgc ccgcgtgcag gacgttggca atgttgcggt ggacgaagac atcgcccggc    11100

ttaagaccaa ggagagtggt ttcggggcat cgggaatcgg agcagccgat ccagagaatc    11160

tcgggctgct ggccgttcgc gagcgtgggg aacagtgagg ggtcttcctt ggagatctgg    11220

gctgcccagt ctttgttctg gtgcagagcg gaggtgaaac ggtctgagtc tgtattagca    11280

cacgctggtg gcttggtggt ggaaaagcag gcggcttgtc gtggtggaaa aaaggagaca    11340

cgctgggagg gaagaggaag gctggctcga gaacttggct gcgcccccga ccggggagag    11400

gtatatattc cgaccctgga atacatccgc tgcagtcgcg aaacaagcct tgtggactcc    11460

atgatggtgt gaagagggta tgaagacaac agaattgacg gaaaatgcag caccacgagg    11520

atgagtcact gccaggggaa ccccgaaaag gaacggaaac cacaaatgaa agcgcaagga    11580

tatcaatacg ttttgcaaat tcgcatacga tgaagcaagc acagtgatac agaaacgggg    11640

gcaaaacgac acgctgaggg ttcggtggca gggaagttga gggaaaagat gaggaaaagg    11700

taaaatctgt gggccgccgc cgctttgcaa gtctatccag aaacgccaag aatggatggt    11760

tctgttctgc tggtgctgat gctcacgtac ctgtagcagt gggcgccatg atagctgatg    11820

ttcaagtgag atatcgcagt gtgcttgtcg gacagtctgt tggattcaag atactgagta    11880

ttttgtgttg gctacgaggc tcccctttct ttctttgccc cccgccggca attccttggg    11940

gattctcgtc ggcaatgttc acccccaacc atgcaaacag tgcaaacacc ccaactcacc    12000

ggacacccaa aggcgcca                                                  12018


<210>  2
<211>  7281
<212>  DNA
<213>  Aspergillus niger


<220>
<221>  misc_feature
<223>  AgsE cDNA

<400>  2
atgaagtggg ctatttccgg cacgctgctc gcctgtttcg caacaactgc aacggcctgg       60

ccttacgacg agtccctcgt cgactacaac ttcaatcaga accagtccgc tacgaacccg      120

gcggactatt ggggaacatg gcccaatcat accggggact acttcccctc cccggacaat      180

tggcgcttcc ccgtctacac cctctttctc gaccgcttcg tcaacggtga ccccacaaac      240

gacaacatca atggcaccct gttcgaacat gacctccgct cgaatcagat gcgccatggt      300

ggcgatgttg ccggcctgct ggataccttg gattacttgc agggcatggg aatcaagggt      360

ctctatcttg ccggaacaat cctcatgaac cagccctggg gatctgacgg ttattcggct      420

ttggacacga cattgttgga tcaacactat ggtaacctgc agacgtggcg caatgccatc      480

acggaaattc acaagcgcgg gatgtatgtc atcttcgata acaccatcgc aacgatgggt      540

gatttgatcg gatttgatgg ctatctgaac accaccaccc ccttctccgt gaaggaacac      600

caaacggtgt ggaagactga ccgccgctat gtggacttcg acattggcaa tgactacaac      660

gagacgtgcg actacccccg cttctggttc gaggatggct accccgttca agcgtcagtc      720

accgaggagc ttgtcggatg ttacaacagt gatttcgacc agtacggtga tattgaggcc      780

tttggtgtct tccccgattg gcaacgtcag ctggcaaaat tcgcctccgt tcaggatcga      840

ctccgtgaat gggttccctc cgtgcgcgag cgtttgatcc gccactcctg catcattatt      900

cagtcgctcg atattgacgg tttccggtac gacaaggcga ctcaggcaac cgtcgacgcc      960

ctcggagata tgtccaatgc gtaccgcgag tgcgcccgcg ccgtaggaaa agagaacttc     1020

ttcattgcgg gcgaaatcac gggtggtaat acctttggtt ccatctactt gggccgagga     1080

agacagccca accagttccc tgactcggcg gaggcagcca tgaagctgac caacacttcc     1140

gacgcccagt atttcctgcg tgaagtggga catgaggcga ttgatggtgc agccttccac     1200

tactccattt accgagcgct gacccgcttc ctgggcatgg atggtaactt ggctgccggt     1260

tacgatgtgc cagtcgactg ggttgatgcc tggaatctca tgctgcagtc caacgatctg     1320

gtcaatgcga atacaggcaa gttcgacccc cgccacatgt acggggctac caaccaggat     1380

gtcttccgtt ggcccacggt ggaaaagggc gtggagcgtc agttgcttgg attgtacatc     1440

acgactcttc tgctccccgg aattccgctc cttctctggg gcgaggaaca ggcgttttac     1500

gtactggatg ccacggcatc gaactacatc tacggtcggc aggccatgtc tcctgccacc     1560

gcatggaggg atcatggctg tttctccttg gaatcgtctc agtactataa ttggcccatt     1620

gagtccggcc gtcagggctg ccacgacccc acggtggcct acgatcatcg tgacccgtct     1680

catcccgtgc gcaatatcat taagcatatg tatcagatgc gcgaacagtt ccccgtcctc     1740

aatgacggct atactattca aaagctctcg aaccacaccg aggacgtgta ctatctcggt     1800

tccaacggca cagccaccga gaccggactc tggtcgattc ttcgtgatgt gaacgcggat     1860

gtgcaggatt tgggctccga tgcgaagaac cagcctgtct ggctggttta ccacaacacg     1920

aaccgcacca ttgattacaa gtttgactgc tcggataatg atacagctct gattgccccc     1980

ttcgatagtg gcacctgggt caaaaacctg ttccacccgt atgacgagca ccagctgatc     2040

gattccccca ccaagttggg attgaacgga tcaactgcat acagtggctg cttggctaat     2100

atgaccatgt ccgcctatga attccgggcc tacgtgccta aaacccgctt tactaaaccc     2160

aggccgatga ttacaaagtt cactccggga cacgatgtcc cgatccgctc gaccgtggcc     2220

ccgaacgcag acgagaacgt ggaggtcgaa atttacttct ccgaagaaat ggattgcgac     2280

tcggtgacaa agtccattac cctttcgtca tcgaccgaaa ttggaaaggc cccctctgtc     2340

gattctggca gtgtcaactg caagtcagtc cccgccacta acaccagctg gaccggccag     2400

attcccgggg tgtggatgtg ggcggccaac ctgacaggtg tgtacaacgg cattcatcgt     2460

ctcacagtca acaatgtcag cacagagagt gggaacgcaa ccaccaacgc cgtcgaccat     2520

ttcctcttcc gcatcggcca gattgataat ccgatgattt tcagcagtgc gaactattca     2580

actagtttgc tccataagga atccaacggc acccttttca tccagcacca cgccgcgggt     2640

gctgataagt atcgctattc tacgaattgg ggtaccactt tctccgattg gattgactac     2700

aggggcggaa atgacactat tgaggaactc gaatggtcgg gaaccaagaa gcagtcatgg     2760

aaaggaaacc acgttcgcgt ggagtattgg agtcgttgga ccggcagcag cgattacgtc     2820

caagagggag acgcgggctg gaacgagaat gttccacgcc gtttccctca cgtcttcttc     2880

aacggaccct acaaccagta tgggtatgat gcaggtctgg acaacgtggt ccgccaggac     2940

agcgttgacg gtctctggaa atatcatttc accgcggaat ggcctgctca agctcaattg     3000

aacatttggg gtatgaaccc tgatggggag cctgaccaga gttgggtcct gggagatgcc     3060

gataatgatt cggttctcga tcgcatgccg ccctcttcgc tgtccgcgac attgattaac     3120

atcactgaac accccccctc tccctacatt tcgtggaata tcttcattga tgacgggacc     3180

atgcgcttcc agctgttccc cgtcgggcat cagaatactc agatcgccat gtatgtgctc     3240

ttttggatca tccccgtcat cacgggcgca gccggtgtgt gggctttcat gaagtctttc     3300

tacaaggtca aattcaacca ggttggtgtg agcgaaaaac accagatgat cccattggcc     3360

ttgcggcgga agttcaagcg caatcgcaat cgtggcggtg atgaggaaaa ctcaaaccct     3420

ctcatgcgtc tggcgaacaa gtccgggttc ctccagactg acacggcgat tggtggtgct     3480

gctagcggca agcgtcgcat ggtcctgatc gccaccatgg agtacgacat tgaggattgg     3540

gccatcaaga tcaagattgg tggtcttggt gtcatggcgc aactcatggg taagactctg     3600

ggtcatcaag acttgatctg ggtggtgcct tgcgttgggg gtgtcgatta ccccgtggac     3660

aaacccgcag agcccatgca tgtcaccatt cttggcaatt cgtacgaggt ccaggtccag     3720

tatcacgtct tgaataacat cacctatgtt ctgctggatg cccctgtgtt ccgtcaacag     3780

tctaagtcag agccttaccc ggctcgcatg gacgacctga acagcgccat ttactactcg     3840

gcctggaatc agtgcattgc ggaagcctgc aagagattcc ctatcgacct gtatcatatc     3900

aacgactacc atggttccct ggctccactg tatctacttc ctgacacagt acctgcctgt     3960

ctttccctgc ataacgccga gttccaaggt ttgtggccca tgcggacgca gaaagaaaag     4020

gaggaagttt gctccgtgtt caatctggat atcgagaccg tgaggcatta cgtgcagttt     4080

ggagaggtgt tcaacttgct ccactcgggt gctagttatc tccgtgttca ccaacaaggt     4140

ttcggtgctg ttggtgtgtc taagaagtac ggaaagcggt cctacgcgcg ttaccccatt     4200

ttctggggtc tccgcaaggt tggaaaccta cctaaccctg atccgtctga tgtcggtgag     4260

tggagcaagg aacaggccag cgccatgggt gacaatgtga gcgtggaccc gacttatgaa     4320

gccggtcgag gcgacctcaa gcgtcaagct caggagtggg ccggtcttga acagaaccct     4380

gacgccgatt tgcttgtctt cgttggtcgt tggtcgatgc agaagggtgt tgatttgatc     4440

gccgacgtca tgcctgctgt cctggaagca cgccccaatg ttcagctcat ttgtgttgga     4500

ccagttatcg atctctacgg taaattcgcg gccctcaaac tcgatcacat gatgaaggtc     4560

taccccggac gagtgttctc tagacctgag ttcacggcat tgccccccta catcttctct     4620

ggtgctgaat tcgcgctgat tccctctcgt gacgagccct tcggtctggt cgccgtcgag     4680

ttcggacgta agggagctct gggtatcggt gcccgggttg gtggtctcgg tcagatgcca     4740

ggttggtggt acaatgtgga atcgacagct acctcccatt tgctcgttca gttcaagctg     4800

gctatcgacg cggctctcag ttcgaaaacg gaaactcgtg ctatgatgcg tgcccggtcc     4860

gccaaacagc gcttcccggt cgcccagtgg gtggaagact tggagatcct gcaaaccacc     4920

gccatccaag tgcacaacaa ggaattggtt aaacataacg gtcgaccctt caccccgtct     4980

ggaactacca cgccgggtgg catcttaagc cagccgtcaa gtccactaat gccccctgga     5040

atgcagactc ccttggctca ttctcgggaa agcagctatt ctaacctgaa ccgtctcagt     5100

gaatatgtca cagatccgaa aacaaactac agtcgagaca tcagccccag tgggacggaa     5160

aagccgcggt ccggcctgca acgacagctt tctcttggtg ttcgctcagg acctggtcat     5220

caagagcgcc gtggccgtcg tggacgccag cgcgacagca tccccgaaca cgaagacacc     5280

gcaggggcca tgaccgacgt cgaagaagac cacgaggaca ttggggatca gcaggatgcg     5340

gacgacgagt acactctcac cccggctcag gtcgaggaag gacgtcgctt gcaggctgtc     5400

cagcagcagg gagtgggtat gccgacgagt ccgggcgtcc gccgttatag tcaagactcc     5460

ttgcatccgc gacagcttcc tagcagccct ggccccgtcc cacctcctac acagagcctc     5520

cttccgccac ccaggcttgg ggatgccggt agccgactca gtagcgcgtc tgtcctgtcc     5580

ctggattcgg tcgttggtac caagacggac ttcaagctcc agaaggttga ccccttcttt     5640

acggattcta ctggcgagta ctacaaggca ttcgacaaga ggctggtcgg cttgaacggc     5700

tcgaactccg aatcccagct ttgcattgag gaatatctca tcaagagtga gaaggaatgg     5760

ttcgacaagt tccgcgatgc ccgactgggt cgtctaaaat cccccgcgtc gtctgtcttc     5820

cgggacaagc atggtgcctc ccctgttggc tcctactacg atgatacggg ctcccgggtg     5880

agtggtgact atgaccggga gtcccgcgac acggaagatg acgagttcct cctgggcaag     5940

gactacgtgc ctccgacggg tctgcgcaag tggatgcaga ttcgtgttgg agactggcca     6000

gtctactcgt tattccttgc cttgggtcag atcattgcag ccaactctta tcaggtgacc     6060

ttgcttaccg gtgaggttgg tgagacggcc gagaagctct atggtatcgc aaccacctac     6120

ctgatcacct cgatcctttg gtggcttgtg ttccgttact tcaaatcggt ggtgtgcctc     6180

tcggctccct ggttcttcta tggccttgcc ttccttctga tcggctccgc tcactttgaa     6240

cccaattcat tcaaccgggg ttggatccag aacatcggaa gtggatgtta cgccgctgcc     6300

tcgtctagcg gttccatctt cttcgccttg aactttggtg acgaaggtgg tgcgccggtc     6360

gaaacctgga tcttccgggc ttgtctcatt cagggtatcc agtcggctta tatcatcgga     6420

ctgtggtatt ggggttccac tctgaccaag gcatccagcc agggtctgtt gacctcgacg     6480

aacaacatcg ccaatagctg gaagatgact gccatctgtt acccgattgc aatcttcctc     6540

tgggctgttg gattgctgct tctctttgga cttcctaact actatcgcca aaccccgggc     6600

aaagtggcct ccttttacaa gtccgtattc cgccgcaaga tcgtcctctg gaacttcgtt     6660

gccgtcatcc tgcaaaactt cttcctcagc gcaccgtacg gccgcaactg gggcttcctt     6720

tggtcttcca atcacgccaa ggcctggcaa atcgttattc tctgtatcgt cttctacggg     6780

ttcgtctggg cgggcttcct gttcgtcgtc agccgctatt tcaagtccca cagctggttc     6840

ctgcccgtgt ttgcgtgcgg acttggagca cctcgcttca ttcaaatctg gtggggtgtc     6900

tcgggcatcg gttacttcct tccctgggtc tccggaggct atctcggcgg agctttggcc     6960

tcgaggagtc tctggctctg gctgggcgtg ttggattcca tccagggtct cgggttcggt     7020

atcatcctcc tgcagaccct cacccgcatg cacatgctgt tcaccctgat ctgctcgcag     7080

gtgcttggtt ccattgccac catctgtgcg cgggcgtttg ccccgaataa cgtcgggccc     7140

ggccctgtgt cgccggaccc tacctttgga ggaagtgcag tggccaatgc gtggttctgg     7200

gtggccctgt tttgtcagct gttgattagt gaggacggct atgcctgcga taacccaaat     7260

tataataata accttcaata a                                               7281


<210>  3
<211>  2426
<212>  PRT
<213>  Aspergillus niger


<220>
<221>  misc_feature
<223>  AgsE protein

<400>  3

Met Lys Trp Ala Ile Ser Gly Thr Leu Leu Ala Cys Phe Ala Thr Thr 
1               5                   10                  15      


Ala Thr Ala Trp Pro Tyr Asp Glu Ser Leu Val Asp Tyr Asn Phe Asn 
            20                  25                  30          


Gln Asn Gln Ser Ala Thr Asn Pro Ala Asp Tyr Trp Gly Thr Trp Pro 
        35                  40                  45              


Asn His Thr Gly Asp Tyr Phe Pro Ser Pro Asp Asn Trp Arg Phe Pro 
    50                  55                  60                  


Val Tyr Thr Leu Phe Leu Asp Arg Phe Val Asn Gly Asp Pro Thr Asn 
65                  70                  75                  80  


Asp Asn Ile Asn Gly Thr Leu Phe Glu His Asp Leu Arg Ser Asn Gln 
                85                  90                  95      


Met Arg His Gly Gly Asp Val Ala Gly Leu Leu Asp Thr Leu Asp Tyr 
            100                 105                 110         


Leu Gln Gly Met Gly Ile Lys Gly Leu Tyr Leu Ala Gly Thr Ile Leu 
        115                 120                 125             


Met Asn Gln Pro Trp Gly Ser Asp Gly Tyr Ser Ala Leu Asp Thr Thr 
    130                 135                 140                 


Leu Leu Asp Gln His Tyr Gly Asn Leu Gln Thr Trp Arg Asn Ala Ile 
145                 150                 155                 160 


Thr Glu Ile His Lys Arg Gly Met Tyr Val Ile Phe Asp Asn Thr Ile 
                165                 170                 175     


Ala Thr Met Gly Asp Leu Ile Gly Phe Asp Gly Tyr Leu Asn Thr Thr 
            180                 185                 190         


Thr Pro Phe Ser Val Lys Glu His Gln Thr Val Trp Lys Thr Asp Arg 
        195                 200                 205             


Arg Tyr Val Asp Phe Asp Ile Gly Asn Asp Tyr Asn Glu Thr Cys Asp 
    210                 215                 220                 


Tyr Pro Arg Phe Trp Phe Glu Asp Gly Tyr Pro Val Gln Ala Ser Val 
225                 230                 235                 240 


Thr Glu Glu Leu Val Gly Cys Tyr Asn Ser Asp Phe Asp Gln Tyr Gly 
                245                 250                 255     


Asp Ile Glu Ala Phe Gly Val Phe Pro Asp Trp Gln Arg Gln Leu Ala 
            260                 265                 270         


Lys Phe Ala Ser Val Gln Asp Arg Leu Arg Glu Trp Val Pro Ser Val 
        275                 280                 285             


Arg Glu Arg Leu Ile Arg His Ser Cys Ile Ile Ile Gln Ser Leu Asp 
    290                 295                 300                 


Ile Asp Gly Phe Arg Tyr Asp Lys Ala Thr Gln Ala Thr Val Asp Ala 
305                 310                 315                 320 


Leu Gly Asp Met Ser Asn Ala Tyr Arg Glu Cys Ala Arg Ala Val Gly 
                325                 330                 335     


Lys Glu Asn Phe Phe Ile Ala Gly Glu Ile Thr Gly Gly Asn Thr Phe 
            340                 345                 350         


Gly Ser Ile Tyr Leu Gly Arg Gly Arg Gln Pro Asn Gln Phe Pro Asp 
        355                 360                 365             


Ser Ala Glu Ala Ala Met Lys Leu Thr Asn Thr Ser Asp Ala Gln Tyr 
    370                 375                 380                 


Phe Leu Arg Glu Val Gly His Glu Ala Ile Asp Gly Ala Ala Phe His 
385                 390                 395                 400 


Tyr Ser Ile Tyr Arg Ala Leu Thr Arg Phe Leu Gly Met Asp Gly Asn 
                405                 410                 415     


Leu Ala Ala Gly Tyr Asp Val Pro Val Asp Trp Val Asp Ala Trp Asn 
            420                 425                 430         


Leu Met Leu Gln Ser Asn Asp Leu Val Asn Ala Asn Thr Gly Lys Phe 
        435                 440                 445             


Asp Pro Arg His Met Tyr Gly Ala Thr Asn Gln Asp Val Phe Arg Trp 
    450                 455                 460                 


Pro Thr Val Glu Lys Gly Val Glu Arg Gln Leu Leu Gly Leu Tyr Ile 
465                 470                 475                 480 


Thr Thr Leu Leu Leu Pro Gly Ile Pro Leu Leu Leu Trp Gly Glu Glu 
                485                 490                 495     


Gln Ala Phe Tyr Val Leu Asp Ala Thr Ala Ser Asn Tyr Ile Tyr Gly 
            500                 505                 510         


Arg Gln Ala Met Ser Pro Ala Thr Ala Trp Arg Asp His Gly Cys Phe 
        515                 520                 525             


Ser Leu Glu Ser Ser Gln Tyr Tyr Asn Trp Pro Ile Glu Ser Gly Arg 
    530                 535                 540                 


Gln Gly Cys His Asp Pro Thr Val Ala Tyr Asp His Arg Asp Pro Ser 
545                 550                 555                 560 


His Pro Val Arg Asn Ile Ile Lys His Met Tyr Gln Met Arg Glu Gln 
                565                 570                 575     


Phe Pro Val Leu Asn Asp Gly Tyr Thr Ile Gln Lys Leu Ser Asn His 
            580                 585                 590         


Thr Glu Asp Val Tyr Tyr Leu Gly Ser Asn Gly Thr Ala Thr Glu Thr 
        595                 600                 605             


Gly Leu Trp Ser Ile Leu Arg Asp Val Asn Ala Asp Val Gln Asp Leu 
    610                 615                 620                 


Gly Ser Asp Ala Lys Asn Gln Pro Val Trp Leu Val Tyr His Asn Thr 
625                 630                 635                 640 


Asn Arg Thr Ile Asp Tyr Lys Phe Asp Cys Ser Asp Asn Asp Thr Ala 
                645                 650                 655     


Leu Ile Ala Pro Phe Asp Ser Gly Thr Trp Val Lys Asn Leu Phe His 
            660                 665                 670         


Pro Tyr Asp Glu His Gln Leu Ile Asp Ser Pro Thr Lys Leu Gly Leu 
        675                 680                 685             


Asn Gly Ser Thr Ala Tyr Ser Gly Cys Leu Ala Asn Met Thr Met Ser 
    690                 695                 700                 


Ala Tyr Glu Phe Arg Ala Tyr Val Pro Lys Thr Arg Phe Thr Lys Pro 
705                 710                 715                 720 


Arg Pro Met Ile Thr Lys Phe Thr Pro Gly His Asp Val Pro Ile Arg 
                725                 730                 735     


Ser Thr Val Ala Pro Asn Ala Asp Glu Asn Val Glu Val Glu Ile Tyr 
            740                 745                 750         


Phe Ser Glu Glu Met Asp Cys Asp Ser Val Thr Lys Ser Ile Thr Leu 
        755                 760                 765             


Ser Ser Ser Thr Glu Ile Gly Lys Ala Pro Ser Val Asp Ser Gly Ser 
    770                 775                 780                 


Val Asn Cys Lys Ser Val Pro Ala Thr Asn Thr Ser Trp Thr Gly Gln 
785                 790                 795                 800 


Ile Pro Gly Val Trp Met Trp Ala Ala Asn Leu Thr Gly Val Tyr Asn 
                805                 810                 815     


Gly Ile His Arg Leu Thr Val Asn Asn Val Ser Thr Glu Ser Gly Asn 
            820                 825                 830         


Ala Thr Thr Asn Ala Val Asp His Phe Leu Phe Arg Ile Gly Gln Ile 
        835                 840                 845             


Asp Asn Pro Met Ile Phe Ser Ser Ala Asn Tyr Ser Thr Ser Leu Leu 
    850                 855                 860                 


His Lys Glu Ser Asn Gly Thr Leu Phe Ile Gln His His Ala Ala Gly 
865                 870                 875                 880 


Ala Asp Lys Tyr Arg Tyr Ser Thr Asn Trp Gly Thr Thr Phe Ser Asp 
                885                 890                 895     


Trp Ile Asp Tyr Arg Gly Gly Asn Asp Thr Ile Glu Glu Leu Glu Trp 
            900                 905                 910         


Ser Gly Thr Lys Lys Gln Ser Trp Lys Gly Asn His Val Arg Val Glu 
        915                 920                 925             


Tyr Trp Ser Arg Trp Thr Gly Ser Ser Asp Tyr Val Gln Glu Gly Asp 
    930                 935                 940                 


Ala Gly Trp Asn Glu Asn Val Pro Arg Arg Phe Pro His Val Phe Phe 
945                 950                 955                 960 


Asn Gly Pro Tyr Asn Gln Tyr Gly Tyr Asp Ala Gly Leu Asp Asn Val 
                965                 970                 975     


Val Arg Gln Asp Ser Val Asp Gly Leu Trp Lys Tyr His Phe Thr Ala 
            980                 985                 990         


Glu Trp Pro Ala Gln Ala Gln Leu  Asn Ile Trp Gly Met  Asn Pro Asp 
        995                 1000                 1005             


Gly Glu  Pro Asp Gln Ser Trp  Val Leu Gly Asp Ala  Asp Asn Asp 
    1010                 1015                 1020             


Ser Val  Leu Asp Arg Met Pro  Pro Ser Ser Leu Ser  Ala Thr Leu 
    1025                 1030                 1035             


Ile Asn  Ile Thr Glu His Pro  Pro Ser Pro Tyr Ile  Ser Trp Asn 
    1040                 1045                 1050             


Ile Phe  Ile Asp Asp Gly Thr  Met Arg Phe Gln Leu  Phe Pro Val 
    1055                 1060                 1065             


Gly His  Gln Asn Thr Gln Ile  Ala Met Tyr Val Leu  Phe Trp Ile 
    1070                 1075                 1080             


Ile Pro  Val Ile Thr Gly Ala  Ala Gly Val Trp Ala  Phe Met Lys 
    1085                 1090                 1095             


Ser Phe  Tyr Lys Val Lys Phe  Asn Gln Val Gly Val  Ser Glu Lys 
    1100                 1105                 1110             


His Gln  Met Ile Pro Leu Ala  Leu Arg Arg Lys Phe  Lys Arg Asn 
    1115                 1120                 1125             


Arg Asn  Arg Gly Gly Asp Glu  Glu Asn Ser Asn Pro  Leu Met Arg 
    1130                 1135                 1140             


Leu Ala  Asn Lys Ser Gly Phe  Leu Gln Thr Asp Thr  Ala Ile Gly 
    1145                 1150                 1155             


Gly Ala  Ala Ser Gly Lys Arg  Arg Met Val Leu Ile  Ala Thr Met 
    1160                 1165                 1170             


Glu Tyr  Asp Ile Glu Asp Trp  Ala Ile Lys Ile Lys  Ile Gly Gly 
    1175                 1180                 1185             


Leu Gly  Val Met Ala Gln Leu  Met Gly Lys Thr Leu  Gly His Gln 
    1190                 1195                 1200             


Asp Leu  Ile Trp Val Val Pro  Cys Val Gly Gly Val  Asp Tyr Pro 
    1205                 1210                 1215             


Val Asp  Lys Pro Ala Glu Pro  Met His Val Thr Ile  Leu Gly Asn 
    1220                 1225                 1230             


Ser Tyr  Glu Val Gln Val Gln  Tyr His Val Leu Asn  Asn Ile Thr 
    1235                 1240                 1245             


Tyr Val  Leu Leu Asp Ala Pro  Val Phe Arg Gln Gln  Ser Lys Ser 
    1250                 1255                 1260             


Glu Pro  Tyr Pro Ala Arg Met  Asp Asp Leu Asn Ser  Ala Ile Tyr 
    1265                 1270                 1275             


Tyr Ser  Ala Trp Asn Gln Cys  Ile Ala Glu Ala Cys  Lys Arg Phe 
    1280                 1285                 1290             


Pro Ile  Asp Leu Tyr His Ile  Asn Asp Tyr His Gly  Ser Leu Ala 
    1295                 1300                 1305             


Pro Leu  Tyr Leu Leu Pro Asp  Thr Val Pro Ala Cys  Leu Ser Leu 
    1310                 1315                 1320             


His Asn  Ala Glu Phe Gln Gly  Leu Trp Pro Met Arg  Thr Gln Lys 
    1325                 1330                 1335             


Glu Lys  Glu Glu Val Cys Ser  Val Phe Asn Leu Asp  Ile Glu Thr 
    1340                 1345                 1350             


Val Arg  His Tyr Val Gln Phe  Gly Glu Val Phe Asn  Leu Leu His 
    1355                 1360                 1365             


Ser Gly  Ala Ser Tyr Leu Arg  Val His Gln Gln Gly  Phe Gly Ala 
    1370                 1375                 1380             


Val Gly  Val Ser Lys Lys Tyr  Gly Lys Arg Ser Tyr  Ala Arg Tyr 
    1385                 1390                 1395             


Pro Ile  Phe Trp Gly Leu Arg  Lys Val Gly Asn Leu  Pro Asn Pro 
    1400                 1405                 1410             


Asp Pro  Ser Asp Val Gly Glu  Trp Ser Lys Glu Gln  Ala Ser Ala 
    1415                 1420                 1425             


Met Gly  Asp Asn Val Ser Val  Asp Pro Thr Tyr Glu  Ala Gly Arg 
    1430                 1435                 1440             


Gly Asp  Leu Lys Arg Gln Ala  Gln Glu Trp Ala Gly  Leu Glu Gln 
    1445                 1450                 1455             


Asn Pro  Asp Ala Asp Leu Leu  Val Phe Val Gly Arg  Trp Ser Met 
    1460                 1465                 1470             


Gln Lys  Gly Val Asp Leu Ile  Ala Asp Val Met Pro  Ala Val Leu 
    1475                 1480                 1485             


Glu Ala  Arg Pro Asn Val Gln  Leu Ile Cys Val Gly  Pro Val Ile 
    1490                 1495                 1500             


Asp Leu  Tyr Gly Lys Phe Ala  Ala Leu Lys Leu Asp  His Met Met 
    1505                 1510                 1515             


Lys Val  Tyr Pro Gly Arg Val  Phe Ser Arg Pro Glu  Phe Thr Ala 
    1520                 1525                 1530             


Leu Pro  Pro Tyr Ile Phe Ser  Gly Ala Glu Phe Ala  Leu Ile Pro 
    1535                 1540                 1545             


Ser Arg  Asp Glu Pro Phe Gly  Leu Val Ala Val Glu  Phe Gly Arg 
    1550                 1555                 1560             


Lys Gly  Ala Leu Gly Ile Gly  Ala Arg Val Gly Gly  Leu Gly Gln 
    1565                 1570                 1575             


Met Pro  Gly Trp Trp Tyr Asn  Val Glu Ser Thr Ala  Thr Ser His 
    1580                 1585                 1590             


Leu Leu  Val Gln Phe Lys Leu  Ala Ile Asp Ala Ala  Leu Ser Ser 
    1595                 1600                 1605             


Lys Thr  Glu Thr Arg Ala Met  Met Arg Ala Arg Ser  Ala Lys Gln 
    1610                 1615                 1620             


Arg Phe  Pro Val Ala Gln Trp  Val Glu Asp Leu Glu  Ile Leu Gln 
    1625                 1630                 1635             


Thr Thr  Ala Ile Gln Val His  Asn Lys Glu Leu Val  Lys His Asn 
    1640                 1645                 1650             


Gly Arg  Pro Phe Thr Pro Ser  Gly Thr Thr Thr Pro  Gly Gly Ile 
    1655                 1660                 1665             


Leu Ser  Gln Pro Ser Ser Pro  Leu Met Pro Pro Gly  Met Gln Thr 
    1670                 1675                 1680             


Pro Leu  Ala His Ser Arg Glu  Ser Ser Tyr Ser Asn  Leu Asn Arg 
    1685                 1690                 1695             


Leu Ser  Glu Tyr Val Thr Asp  Pro Lys Thr Asn Tyr  Ser Arg Asp 
    1700                 1705                 1710             


Ile Ser  Pro Ser Gly Thr Glu  Lys Pro Arg Ser Gly  Leu Gln Arg 
    1715                 1720                 1725             


Gln Leu  Ser Leu Gly Val Arg  Ser Gly Pro Gly His  Gln Glu Arg 
    1730                 1735                 1740             


Arg Gly  Arg Arg Gly Arg Gln  Arg Asp Ser Ile Pro  Glu His Glu 
    1745                 1750                 1755             


Asp Thr  Ala Gly Ala Met Thr  Asp Val Glu Glu Asp  His Glu Asp 
    1760                 1765                 1770             


Ile Gly  Asp Gln Gln Asp Ala  Asp Asp Glu Tyr Thr  Leu Thr Pro 
    1775                 1780                 1785             


Ala Gln  Val Glu Glu Gly Arg  Arg Leu Gln Ala Val  Gln Gln Gln 
    1790                 1795                 1800             


Gly Val  Gly Met Pro Thr Ser  Pro Gly Val Arg Arg  Tyr Ser Gln 
    1805                 1810                 1815             


Asp Ser  Leu His Pro Arg Gln  Leu Pro Ser Ser Pro  Gly Pro Val 
    1820                 1825                 1830             


Pro Pro  Pro Thr Gln Ser Leu  Leu Pro Pro Pro Arg  Leu Gly Asp 
    1835                 1840                 1845             


Ala Gly  Ser Arg Leu Ser Ser  Ala Ser Val Leu Ser  Leu Asp Ser 
    1850                 1855                 1860             


Val Val  Gly Thr Lys Thr Asp  Phe Lys Leu Gln Lys  Val Asp Pro 
    1865                 1870                 1875             


Phe Phe  Thr Asp Ser Thr Gly  Glu Tyr Tyr Lys Ala  Phe Asp Lys 
    1880                 1885                 1890             


Arg Leu  Val Gly Leu Asn Gly  Ser Asn Ser Glu Ser  Gln Leu Cys 
    1895                 1900                 1905             


Ile Glu  Glu Tyr Leu Ile Lys  Ser Glu Lys Glu Trp  Phe Asp Lys 
    1910                 1915                 1920             


Phe Arg  Asp Ala Arg Leu Gly  Arg Leu Lys Ser Pro  Ala Ser Ser 
    1925                 1930                 1935             


Val Phe  Arg Asp Lys His Gly  Ala Ser Pro Val Gly  Ser Tyr Tyr 
    1940                 1945                 1950             


Asp Asp  Thr Gly Ser Arg Val  Ser Gly Asp Tyr Asp  Arg Glu Ser 
    1955                 1960                 1965             


Arg Asp  Thr Glu Asp Asp Glu  Phe Leu Leu Gly Lys  Asp Tyr Val 
    1970                 1975                 1980             


Pro Pro  Thr Gly Leu Arg Lys  Trp Met Gln Ile Arg  Val Gly Asp 
    1985                 1990                 1995             


Trp Pro  Val Tyr Ser Leu Phe  Leu Ala Leu Gly Gln  Ile Ile Ala 
    2000                 2005                 2010             


Ala Asn  Ser Tyr Gln Val Thr  Leu Leu Thr Gly Glu  Val Gly Glu 
    2015                 2020                 2025             


Thr Ala  Glu Lys Leu Tyr Gly  Ile Ala Thr Thr Tyr  Leu Ile Thr 
    2030                 2035                 2040             


Ser Ile  Leu Trp Trp Leu Val  Phe Arg Tyr Phe Lys  Ser Val Val 
    2045                 2050                 2055             


Cys Leu  Ser Ala Pro Trp Phe  Phe Tyr Gly Leu Ala  Phe Leu Leu 
    2060                 2065                 2070             


Ile Gly  Ser Ala His Phe Glu  Pro Asn Ser Phe Asn  Arg Gly Trp 
    2075                 2080                 2085             


Ile Gln  Asn Ile Gly Ser Gly  Cys Tyr Ala Ala Ala  Ser Ser Ser 
    2090                 2095                 2100             


Gly Ser  Ile Phe Phe Ala Leu  Asn Phe Gly Asp Glu  Gly Gly Ala 
    2105                 2110                 2115             


Pro Val  Glu Thr Trp Ile Phe  Arg Ala Cys Leu Ile  Gln Gly Ile 
    2120                 2125                 2130             


Gln Ser  Ala Tyr Ile Ile Gly  Leu Trp Tyr Trp Gly  Ser Thr Leu 
    2135                 2140                 2145             


Thr Lys  Ala Ser Ser Gln Gly  Leu Leu Thr Ser Thr  Asn Asn Ile 
    2150                 2155                 2160             


Ala Asn  Ser Trp Lys Met Thr  Ala Ile Cys Tyr Pro  Ile Ala Ile 
    2165                 2170                 2175             


Phe Leu  Trp Ala Val Gly Leu  Leu Leu Leu Phe Gly  Leu Pro Asn 
    2180                 2185                 2190             


Tyr Tyr  Arg Gln Thr Pro Gly  Lys Val Ala Ser Phe  Tyr Lys Ser 
    2195                 2200                 2205             


Val Phe  Arg Arg Lys Ile Val  Leu Trp Asn Phe Val  Ala Val Ile 
    2210                 2215                 2220             


Leu Gln  Asn Phe Phe Leu Ser  Ala Pro Tyr Gly Arg  Asn Trp Gly 
    2225                 2230                 2235             


Phe Leu  Trp Ser Ser Asn His  Ala Lys Ala Trp Gln  Ile Val Ile 
    2240                 2245                 2250             


Leu Cys  Ile Val Phe Tyr Gly  Phe Val Trp Ala Gly  Phe Leu Phe 
    2255                 2260                 2265             


Val Val  Ser Arg Tyr Phe Lys  Ser His Ser Trp Phe  Leu Pro Val 
    2270                 2275                 2280             


Phe Ala  Cys Gly Leu Gly Ala  Pro Arg Phe Ile Gln  Ile Trp Trp 
    2285                 2290                 2295             


Gly Val  Ser Gly Ile Gly Tyr  Phe Leu Pro Trp Val  Ser Gly Gly 
    2300                 2305                 2310             


Tyr Leu  Gly Gly Ala Leu Ala  Ser Arg Ser Leu Trp  Leu Trp Leu 
    2315                 2320                 2325             


Gly Val  Leu Asp Ser Ile Gln  Gly Leu Gly Phe Gly  Ile Ile Leu 
    2330                 2335                 2340             


Leu Gln  Thr Leu Thr Arg Met  His Met Leu Phe Thr  Leu Ile Cys 
    2345                 2350                 2355             


Ser Gln  Val Leu Gly Ser Ile  Ala Thr Ile Cys Ala  Arg Ala Phe 
    2360                 2365                 2370             


Ala Pro  Asn Asn Val Gly Pro  Gly Pro Val Ser Pro  Asp Pro Thr 
    2375                 2380                 2385             


Phe Gly  Gly Ser Ala Val Ala  Asn Ala Trp Phe Trp  Val Ala Leu 
    2390                 2395                 2400             


Phe Cys  Gln Leu Leu Ile Ser  Glu Asp Gly Tyr Ala  Cys Asp Asn 
    2405                 2410                 2415             


Pro Asn  Tyr Asn Asn Asn Leu  Gln 
    2420                 2425     


<210>  4
<211>  2407
<212>  PRT
<213>  Aspergillus niger


<220>
<221>  misc_feature
<223>  AgsE mature protein

<400>  4

Trp Pro Tyr Asp Glu Ser Leu Val Asp Tyr Asn Phe Asn Gln Asn Gln 
1               5                   10                  15      


Ser Ala Thr Asn Pro Ala Asp Tyr Trp Gly Thr Trp Pro Asn His Thr 
            20                  25                  30          


Gly Asp Tyr Phe Pro Ser Pro Asp Asn Trp Arg Phe Pro Val Tyr Thr 
        35                  40                  45              


Leu Phe Leu Asp Arg Phe Val Asn Gly Asp Pro Thr Asn Asp Asn Ile 
    50                  55                  60                  


Asn Gly Thr Leu Phe Glu His Asp Leu Arg Ser Asn Gln Met Arg His 
65                  70                  75                  80  


Gly Gly Asp Val Ala Gly Leu Leu Asp Thr Leu Asp Tyr Leu Gln Gly 
                85                  90                  95      


Met Gly Ile Lys Gly Leu Tyr Leu Ala Gly Thr Ile Leu Met Asn Gln 
            100                 105                 110         


Pro Trp Gly Ser Asp Gly Tyr Ser Ala Leu Asp Thr Thr Leu Leu Asp 
        115                 120                 125             


Gln His Tyr Gly Asn Leu Gln Thr Trp Arg Asn Ala Ile Thr Glu Ile 
    130                 135                 140                 


His Lys Arg Gly Met Tyr Val Ile Phe Asp Asn Thr Ile Ala Thr Met 
145                 150                 155                 160 


Gly Asp Leu Ile Gly Phe Asp Gly Tyr Leu Asn Thr Thr Thr Pro Phe 
                165                 170                 175     


Ser Val Lys Glu His Gln Thr Val Trp Lys Thr Asp Arg Arg Tyr Val 
            180                 185                 190         


Asp Phe Asp Ile Gly Asn Asp Tyr Asn Glu Thr Cys Asp Tyr Pro Arg 
        195                 200                 205             


Phe Trp Phe Glu Asp Gly Tyr Pro Val Gln Ala Ser Val Thr Glu Glu 
    210                 215                 220                 


Leu Val Gly Cys Tyr Asn Ser Asp Phe Asp Gln Tyr Gly Asp Ile Glu 
225                 230                 235                 240 


Ala Phe Gly Val Phe Pro Asp Trp Gln Arg Gln Leu Ala Lys Phe Ala 
                245                 250                 255     


Ser Val Gln Asp Arg Leu Arg Glu Trp Val Pro Ser Val Arg Glu Arg 
            260                 265                 270         


Leu Ile Arg His Ser Cys Ile Ile Ile Gln Ser Leu Asp Ile Asp Gly 
        275                 280                 285             


Phe Arg Tyr Asp Lys Ala Thr Gln Ala Thr Val Asp Ala Leu Gly Asp 
    290                 295                 300                 


Met Ser Asn Ala Tyr Arg Glu Cys Ala Arg Ala Val Gly Lys Glu Asn 
305                 310                 315                 320 


Phe Phe Ile Ala Gly Glu Ile Thr Gly Gly Asn Thr Phe Gly Ser Ile 
                325                 330                 335     


Tyr Leu Gly Arg Gly Arg Gln Pro Asn Gln Phe Pro Asp Ser Ala Glu 
            340                 345                 350         


Ala Ala Met Lys Leu Thr Asn Thr Ser Asp Ala Gln Tyr Phe Leu Arg 
        355                 360                 365             


Glu Val Gly His Glu Ala Ile Asp Gly Ala Ala Phe His Tyr Ser Ile 
    370                 375                 380                 


Tyr Arg Ala Leu Thr Arg Phe Leu Gly Met Asp Gly Asn Leu Ala Ala 
385                 390                 395                 400 


Gly Tyr Asp Val Pro Val Asp Trp Val Asp Ala Trp Asn Leu Met Leu 
                405                 410                 415     


Gln Ser Asn Asp Leu Val Asn Ala Asn Thr Gly Lys Phe Asp Pro Arg 
            420                 425                 430         


His Met Tyr Gly Ala Thr Asn Gln Asp Val Phe Arg Trp Pro Thr Val 
        435                 440                 445             


Glu Lys Gly Val Glu Arg Gln Leu Leu Gly Leu Tyr Ile Thr Thr Leu 
    450                 455                 460                 


Leu Leu Pro Gly Ile Pro Leu Leu Leu Trp Gly Glu Glu Gln Ala Phe 
465                 470                 475                 480 


Tyr Val Leu Asp Ala Thr Ala Ser Asn Tyr Ile Tyr Gly Arg Gln Ala 
                485                 490                 495     


Met Ser Pro Ala Thr Ala Trp Arg Asp His Gly Cys Phe Ser Leu Glu 
            500                 505                 510         


Ser Ser Gln Tyr Tyr Asn Trp Pro Ile Glu Ser Gly Arg Gln Gly Cys 
        515                 520                 525             


His Asp Pro Thr Val Ala Tyr Asp His Arg Asp Pro Ser His Pro Val 
    530                 535                 540                 


Arg Asn Ile Ile Lys His Met Tyr Gln Met Arg Glu Gln Phe Pro Val 
545                 550                 555                 560 


Leu Asn Asp Gly Tyr Thr Ile Gln Lys Leu Ser Asn His Thr Glu Asp 
                565                 570                 575     


Val Tyr Tyr Leu Gly Ser Asn Gly Thr Ala Thr Glu Thr Gly Leu Trp 
            580                 585                 590         


Ser Ile Leu Arg Asp Val Asn Ala Asp Val Gln Asp Leu Gly Ser Asp 
        595                 600                 605             


Ala Lys Asn Gln Pro Val Trp Leu Val Tyr His Asn Thr Asn Arg Thr 
    610                 615                 620                 


Ile Asp Tyr Lys Phe Asp Cys Ser Asp Asn Asp Thr Ala Leu Ile Ala 
625                 630                 635                 640 


Pro Phe Asp Ser Gly Thr Trp Val Lys Asn Leu Phe His Pro Tyr Asp 
                645                 650                 655     


Glu His Gln Leu Ile Asp Ser Pro Thr Lys Leu Gly Leu Asn Gly Ser 
            660                 665                 670         


Thr Ala Tyr Ser Gly Cys Leu Ala Asn Met Thr Met Ser Ala Tyr Glu 
        675                 680                 685             


Phe Arg Ala Tyr Val Pro Lys Thr Arg Phe Thr Lys Pro Arg Pro Met 
    690                 695                 700                 


Ile Thr Lys Phe Thr Pro Gly His Asp Val Pro Ile Arg Ser Thr Val 
705                 710                 715                 720 


Ala Pro Asn Ala Asp Glu Asn Val Glu Val Glu Ile Tyr Phe Ser Glu 
                725                 730                 735     


Glu Met Asp Cys Asp Ser Val Thr Lys Ser Ile Thr Leu Ser Ser Ser 
            740                 745                 750         


Thr Glu Ile Gly Lys Ala Pro Ser Val Asp Ser Gly Ser Val Asn Cys 
        755                 760                 765             


Lys Ser Val Pro Ala Thr Asn Thr Ser Trp Thr Gly Gln Ile Pro Gly 
    770                 775                 780                 


Val Trp Met Trp Ala Ala Asn Leu Thr Gly Val Tyr Asn Gly Ile His 
785                 790                 795                 800 


Arg Leu Thr Val Asn Asn Val Ser Thr Glu Ser Gly Asn Ala Thr Thr 
                805                 810                 815     


Asn Ala Val Asp His Phe Leu Phe Arg Ile Gly Gln Ile Asp Asn Pro 
            820                 825                 830         


Met Ile Phe Ser Ser Ala Asn Tyr Ser Thr Ser Leu Leu His Lys Glu 
        835                 840                 845             


Ser Asn Gly Thr Leu Phe Ile Gln His His Ala Ala Gly Ala Asp Lys 
    850                 855                 860                 


Tyr Arg Tyr Ser Thr Asn Trp Gly Thr Thr Phe Ser Asp Trp Ile Asp 
865                 870                 875                 880 


Tyr Arg Gly Gly Asn Asp Thr Ile Glu Glu Leu Glu Trp Ser Gly Thr 
                885                 890                 895     


Lys Lys Gln Ser Trp Lys Gly Asn His Val Arg Val Glu Tyr Trp Ser 
            900                 905                 910         


Arg Trp Thr Gly Ser Ser Asp Tyr Val Gln Glu Gly Asp Ala Gly Trp 
        915                 920                 925             


Asn Glu Asn Val Pro Arg Arg Phe Pro His Val Phe Phe Asn Gly Pro 
    930                 935                 940                 


Tyr Asn Gln Tyr Gly Tyr Asp Ala Gly Leu Asp Asn Val Val Arg Gln 
945                 950                 955                 960 


Asp Ser Val Asp Gly Leu Trp Lys Tyr His Phe Thr Ala Glu Trp Pro 
                965                 970                 975     


Ala Gln Ala Gln Leu Asn Ile Trp Gly Met Asn Pro Asp Gly Glu Pro 
            980                 985                 990         


Asp Gln Ser Trp Val Leu Gly Asp  Ala Asp Asn Asp Ser  Val Leu Asp 
        995                 1000                 1005             


Arg Met  Pro Pro Ser Ser Leu  Ser Ala Thr Leu Ile  Asn Ile Thr 
    1010                 1015                 1020             


Glu His  Pro Pro Ser Pro Tyr  Ile Ser Trp Asn Ile  Phe Ile Asp 
    1025                 1030                 1035             


Asp Gly  Thr Met Arg Phe Gln  Leu Phe Pro Val Gly  His Gln Asn 
    1040                 1045                 1050             


Thr Gln  Ile Ala Met Tyr Val  Leu Phe Trp Ile Ile  Pro Val Ile 
    1055                 1060                 1065             


Thr Gly  Ala Ala Gly Val Trp  Ala Phe Met Lys Ser  Phe Tyr Lys 
    1070                 1075                 1080             


Val Lys  Phe Asn Gln Val Gly  Val Ser Glu Lys His  Gln Met Ile 
    1085                 1090                 1095             


Pro Leu  Ala Leu Arg Arg Lys  Phe Lys Arg Asn Arg  Asn Arg Gly 
    1100                 1105                 1110             


Gly Asp  Glu Glu Asn Ser Asn  Pro Leu Met Arg Leu  Ala Asn Lys 
    1115                 1120                 1125             


Ser Gly  Phe Leu Gln Thr Asp  Thr Ala Ile Gly Gly  Ala Ala Ser 
    1130                 1135                 1140             


Gly Lys  Arg Arg Met Val Leu  Ile Ala Thr Met Glu  Tyr Asp Ile 
    1145                 1150                 1155             


Glu Asp  Trp Ala Ile Lys Ile  Lys Ile Gly Gly Leu  Gly Val Met 
    1160                 1165                 1170             


Ala Gln  Leu Met Gly Lys Thr  Leu Gly His Gln Asp  Leu Ile Trp 
    1175                 1180                 1185             


Val Val  Pro Cys Val Gly Gly  Val Asp Tyr Pro Val  Asp Lys Pro 
    1190                 1195                 1200             


Ala Glu  Pro Met His Val Thr  Ile Leu Gly Asn Ser  Tyr Glu Val 
    1205                 1210                 1215             


Gln Val  Gln Tyr His Val Leu  Asn Asn Ile Thr Tyr  Val Leu Leu 
    1220                 1225                 1230             


Asp Ala  Pro Val Phe Arg Gln  Gln Ser Lys Ser Glu  Pro Tyr Pro 
    1235                 1240                 1245             


Ala Arg  Met Asp Asp Leu Asn  Ser Ala Ile Tyr Tyr  Ser Ala Trp 
    1250                 1255                 1260             


Asn Gln  Cys Ile Ala Glu Ala  Cys Lys Arg Phe Pro  Ile Asp Leu 
    1265                 1270                 1275             


Tyr His  Ile Asn Asp Tyr His  Gly Ser Leu Ala Pro  Leu Tyr Leu 
    1280                 1285                 1290             


Leu Pro  Asp Thr Val Pro Ala  Cys Leu Ser Leu His  Asn Ala Glu 
    1295                 1300                 1305             


Phe Gln  Gly Leu Trp Pro Met  Arg Thr Gln Lys Glu  Lys Glu Glu 
    1310                 1315                 1320             


Val Cys  Ser Val Phe Asn Leu  Asp Ile Glu Thr Val  Arg His Tyr 
    1325                 1330                 1335             


Val Gln  Phe Gly Glu Val Phe  Asn Leu Leu His Ser  Gly Ala Ser 
    1340                 1345                 1350             


Tyr Leu  Arg Val His Gln Gln  Gly Phe Gly Ala Val  Gly Val Ser 
    1355                 1360                 1365             


Lys Lys  Tyr Gly Lys Arg Ser  Tyr Ala Arg Tyr Pro  Ile Phe Trp 
    1370                 1375                 1380             


Gly Leu  Arg Lys Val Gly Asn  Leu Pro Asn Pro Asp  Pro Ser Asp 
    1385                 1390                 1395             


Val Gly  Glu Trp Ser Lys Glu  Gln Ala Ser Ala Met  Gly Asp Asn 
    1400                 1405                 1410             


Val Ser  Val Asp Pro Thr Tyr  Glu Ala Gly Arg Gly  Asp Leu Lys 
    1415                 1420                 1425             


Arg Gln  Ala Gln Glu Trp Ala  Gly Leu Glu Gln Asn  Pro Asp Ala 
    1430                 1435                 1440             


Asp Leu  Leu Val Phe Val Gly  Arg Trp Ser Met Gln  Lys Gly Val 
    1445                 1450                 1455             


Asp Leu  Ile Ala Asp Val Met  Pro Ala Val Leu Glu  Ala Arg Pro 
    1460                 1465                 1470             


Asn Val  Gln Leu Ile Cys Val  Gly Pro Val Ile Asp  Leu Tyr Gly 
    1475                 1480                 1485             


Lys Phe  Ala Ala Leu Lys Leu  Asp His Met Met Lys  Val Tyr Pro 
    1490                 1495                 1500             


Gly Arg  Val Phe Ser Arg Pro  Glu Phe Thr Ala Leu  Pro Pro Tyr 
    1505                 1510                 1515             


Ile Phe  Ser Gly Ala Glu Phe  Ala Leu Ile Pro Ser  Arg Asp Glu 
    1520                 1525                 1530             


Pro Phe  Gly Leu Val Ala Val  Glu Phe Gly Arg Lys  Gly Ala Leu 
    1535                 1540                 1545             


Gly Ile  Gly Ala Arg Val Gly  Gly Leu Gly Gln Met  Pro Gly Trp 
    1550                 1555                 1560             


Trp Tyr  Asn Val Glu Ser Thr  Ala Thr Ser His Leu  Leu Val Gln 
    1565                 1570                 1575             


Phe Lys  Leu Ala Ile Asp Ala  Ala Leu Ser Ser Lys  Thr Glu Thr 
    1580                 1585                 1590             


Arg Ala  Met Met Arg Ala Arg  Ser Ala Lys Gln Arg  Phe Pro Val 
    1595                 1600                 1605             


Ala Gln  Trp Val Glu Asp Leu  Glu Ile Leu Gln Thr  Thr Ala Ile 
    1610                 1615                 1620             


Gln Val  His Asn Lys Glu Leu  Val Lys His Asn Gly  Arg Pro Phe 
    1625                 1630                 1635             


Thr Pro  Ser Gly Thr Thr Thr  Pro Gly Gly Ile Leu  Ser Gln Pro 
    1640                 1645                 1650             


Ser Ser  Pro Leu Met Pro Pro  Gly Met Gln Thr Pro  Leu Ala His 
    1655                 1660                 1665             


Ser Arg  Glu Ser Ser Tyr Ser  Asn Leu Asn Arg Leu  Ser Glu Tyr 
    1670                 1675                 1680             


Val Thr  Asp Pro Lys Thr Asn  Tyr Ser Arg Asp Ile  Ser Pro Ser 
    1685                 1690                 1695             


Gly Thr  Glu Lys Pro Arg Ser  Gly Leu Gln Arg Gln  Leu Ser Leu 
    1700                 1705                 1710             


Gly Val  Arg Ser Gly Pro Gly  His Gln Glu Arg Arg  Gly Arg Arg 
    1715                 1720                 1725             


Gly Arg  Gln Arg Asp Ser Ile  Pro Glu His Glu Asp  Thr Ala Gly 
    1730                 1735                 1740             


Ala Met  Thr Asp Val Glu Glu  Asp His Glu Asp Ile  Gly Asp Gln 
    1745                 1750                 1755             


Gln Asp  Ala Asp Asp Glu Tyr  Thr Leu Thr Pro Ala  Gln Val Glu 
    1760                 1765                 1770             


Glu Gly  Arg Arg Leu Gln Ala  Val Gln Gln Gln Gly  Val Gly Met 
    1775                 1780                 1785             


Pro Thr  Ser Pro Gly Val Arg  Arg Tyr Ser Gln Asp  Ser Leu His 
    1790                 1795                 1800             


Pro Arg  Gln Leu Pro Ser Ser  Pro Gly Pro Val Pro  Pro Pro Thr 
    1805                 1810                 1815             


Gln Ser  Leu Leu Pro Pro Pro  Arg Leu Gly Asp Ala  Gly Ser Arg 
    1820                 1825                 1830             


Leu Ser  Ser Ala Ser Val Leu  Ser Leu Asp Ser Val  Val Gly Thr 
    1835                 1840                 1845             


Lys Thr  Asp Phe Lys Leu Gln  Lys Val Asp Pro Phe  Phe Thr Asp 
    1850                 1855                 1860             


Ser Thr  Gly Glu Tyr Tyr Lys  Ala Phe Asp Lys Arg  Leu Val Gly 
    1865                 1870                 1875             


Leu Asn  Gly Ser Asn Ser Glu  Ser Gln Leu Cys Ile  Glu Glu Tyr 
    1880                 1885                 1890             


Leu Ile  Lys Ser Glu Lys Glu  Trp Phe Asp Lys Phe  Arg Asp Ala 
    1895                 1900                 1905             


Arg Leu  Gly Arg Leu Lys Ser  Pro Ala Ser Ser Val  Phe Arg Asp 
    1910                 1915                 1920             


Lys His  Gly Ala Ser Pro Val  Gly Ser Tyr Tyr Asp  Asp Thr Gly 
    1925                 1930                 1935             


Ser Arg  Val Ser Gly Asp Tyr  Asp Arg Glu Ser Arg  Asp Thr Glu 
    1940                 1945                 1950             


Asp Asp  Glu Phe Leu Leu Gly  Lys Asp Tyr Val Pro  Pro Thr Gly 
    1955                 1960                 1965             


Leu Arg  Lys Trp Met Gln Ile  Arg Val Gly Asp Trp  Pro Val Tyr 
    1970                 1975                 1980             


Ser Leu  Phe Leu Ala Leu Gly  Gln Ile Ile Ala Ala  Asn Ser Tyr 
    1985                 1990                 1995             


Gln Val  Thr Leu Leu Thr Gly  Glu Val Gly Glu Thr  Ala Glu Lys 
    2000                 2005                 2010             


Leu Tyr  Gly Ile Ala Thr Thr  Tyr Leu Ile Thr Ser  Ile Leu Trp 
    2015                 2020                 2025             


Trp Leu  Val Phe Arg Tyr Phe  Lys Ser Val Val Cys  Leu Ser Ala 
    2030                 2035                 2040             


Pro Trp  Phe Phe Tyr Gly Leu  Ala Phe Leu Leu Ile  Gly Ser Ala 
    2045                 2050                 2055             


His Phe  Glu Pro Asn Ser Phe  Asn Arg Gly Trp Ile  Gln Asn Ile 
    2060                 2065                 2070             


Gly Ser  Gly Cys Tyr Ala Ala  Ala Ser Ser Ser Gly  Ser Ile Phe 
    2075                 2080                 2085             


Phe Ala  Leu Asn Phe Gly Asp  Glu Gly Gly Ala Pro  Val Glu Thr 
    2090                 2095                 2100             


Trp Ile  Phe Arg Ala Cys Leu  Ile Gln Gly Ile Gln  Ser Ala Tyr 
    2105                 2110                 2115             


Ile Ile  Gly Leu Trp Tyr Trp  Gly Ser Thr Leu Thr  Lys Ala Ser 
    2120                 2125                 2130             


Ser Gln  Gly Leu Leu Thr Ser  Thr Asn Asn Ile Ala  Asn Ser Trp 
    2135                 2140                 2145             


Lys Met  Thr Ala Ile Cys Tyr  Pro Ile Ala Ile Phe  Leu Trp Ala 
    2150                 2155                 2160             


Val Gly  Leu Leu Leu Leu Phe  Gly Leu Pro Asn Tyr  Tyr Arg Gln 
    2165                 2170                 2175             


Thr Pro  Gly Lys Val Ala Ser  Phe Tyr Lys Ser Val  Phe Arg Arg 
    2180                 2185                 2190             


Lys Ile  Val Leu Trp Asn Phe  Val Ala Val Ile Leu  Gln Asn Phe 
    2195                 2200                 2205             


Phe Leu  Ser Ala Pro Tyr Gly  Arg Asn Trp Gly Phe  Leu Trp Ser 
    2210                 2215                 2220             


Ser Asn  His Ala Lys Ala Trp  Gln Ile Val Ile Leu  Cys Ile Val 
    2225                 2230                 2235             


Phe Tyr  Gly Phe Val Trp Ala  Gly Phe Leu Phe Val  Val Ser Arg 
    2240                 2245                 2250             


Tyr Phe  Lys Ser His Ser Trp  Phe Leu Pro Val Phe  Ala Cys Gly 
    2255                 2260                 2265             


Leu Gly  Ala Pro Arg Phe Ile  Gln Ile Trp Trp Gly  Val Ser Gly 
    2270                 2275                 2280             


Ile Gly  Tyr Phe Leu Pro Trp  Val Ser Gly Gly Tyr  Leu Gly Gly 
    2285                 2290                 2295             


Ala Leu  Ala Ser Arg Ser Leu  Trp Leu Trp Leu Gly  Val Leu Asp 
    2300                 2305                 2310             


Ser Ile  Gln Gly Leu Gly Phe  Gly Ile Ile Leu Leu  Gln Thr Leu 
    2315                 2320                 2325             


Thr Arg  Met His Met Leu Phe  Thr Leu Ile Cys Ser  Gln Val Leu 
    2330                 2335                 2340             


Gly Ser  Ile Ala Thr Ile Cys  Ala Arg Ala Phe Ala  Pro Asn Asn 
    2345                 2350                 2355             


Val Gly  Pro Gly Pro Val Ser  Pro Asp Pro Thr Phe  Gly Gly Ser 
    2360                 2365                 2370             


Ala Val  Ala Asn Ala Trp Phe  Trp Val Ala Leu Phe  Cys Gln Leu 
    2375                 2380                 2385             


Leu Ile  Ser Glu Asp Gly Tyr  Ala Cys Asp Asn Pro  Asn Tyr Asn 
    2390                 2395                 2400             


Asn Asn  Leu Gln 
    2405         


<210>  5
<211>  6909
<212>  DNA
<213>  Aspergillus niger


<220>
<221>  misc_feature
<223>  AgdB genomic DNA including 2kb upstream and downstream flanking 
       regions

<400>  5
tatgagttat gaagatggtg cgctcttgga acctctgagt gtttctctgg cgggtattga       60

acgtagtggc cttcgcttgg gtgacccatg cctagtcact ggtgctggcc ctattggtct      120

catcaccctg ttgagtgctc gtgctgctgg agctagccct atcgtcatta ccgacatcga      180

cgaggggcgg ctggaattcg ccaagtcgct ggtccctgac gttcgcactt acaaggtgca      240

gattggcctc tctgctgagc agaatgctga aggtatcatc aacgtcttca acgatgggca      300

aggctcgggc cccggcgctt tgaggcctcg cattgcgatg gagtgcactg gtgtggagag      360

cagtgttgct tcggcgattt ggagtgtcaa gttcggcggc aaggtcttcg tcattggtgt      420

cggaaagaac gagatgaccg ttcctttcat gcgcctcagt acttgggaga ttgacctcca      480

gtaccagtac cggtactgca acacttggcc tcgcgcgatc cgcttggtga ggaacggtgt      540

tattgacttg aagaagcttg tgacacaccg gttcctcttg gaggatgcga tcaaggcctt      600

cgaaacggct gccaacccca agacgggagc catcaaggtt caaatcatga gctccgaaga      660

cgatgtgaag gctgcttccg ctggtcagaa gatttaaaca gtcgtacatt cgtgagcaca      720

tgcctccact gctttatatt gggtgactgg tcaccttgga tacctttcgc attcatgaca      780

catatttttc atgacatttt gatggatggt ttatcgtgta acgttcccct tttttatgac      840

gttgttagag atccctgctg gttggaggca tagagatgca cgtagaattc tattccttca      900

tttttgactc tcacaacatc tgcatccgac atatcgcagg tagagaagct gtctctcatc      960

gcattgacaa gcctttgcat agaatgaagc ggcagagtaa cccagagctg cagcttgact     1020

gaacactttg tcttaacgca tctgcacact tcccccaggt ccccaagctt ctgccagggt     1080

acccggcctg ctggaggagt gaatatgcac acctcgagtg ccacattaat tagtacgatg     1140

tggtcaatac cttatgccac ctcattgctt aatgcttgca gcactggcag taagcgaccg     1200

cctcttgaca ggtcagagcc acctatcagc tacaactacg tatcagcaga ccggatccgt     1260

tgcatccgac gctttgtctg actcttgtgc ggtttttgag tgaccagaat atttactttg     1320

gtccatgttc tttgagtgag atctgatcct gatcctttga atgtctcagt ttgtttgttt     1380

gcggggcgtc aggcggggca cgtggtgggg agagtgagga gagccaccat cactgtcact     1440

tcctcgattc catctccata ctactattcg ctaccaaaag cttacttgca taaaatttgg     1500

agccaatcat ccagggcatt accgagagat ataccgatta gacgtgccca gagtctaggc     1560

tgctgcacga gattcaatga acgagaatcg gtgtaagtga cctgatgtta tttggtccct     1620

gcatcagccc caagccgata gcggcgaaga tccccgataa ttgaccgaga tgggacgacc     1680

ttagactcac attgtcttct ttaggcaatc gtctccacgt ttctcggctt ttctatccta     1740

taaatattgc tttttgtttt tcctcataga actgctcggc tcatcccgcc tctttgtcag     1800

atacattcct tggcttcgct gattgaatct gcggggtccg gtcataccgc gcaacgccac     1860

attatgcact tcggccaacg cgccatgcat tcaatgtcat cagtccgtgc ccaaacacat     1920

ataagccgct gggaccaccc agctgggata tgaagtcacg gcttgctgta atccggggtg     1980

atcccagagc caacatcata atgttggggt ctttgctttt actcttaccc cttgtgggcg     2040

ctgctgtcat tggacccagg gcaaacagtc agagttgccc agggtataag gcgtccaacg     2100

tccaaaagca ggctaggtca ctgactgcgg atctgactct agctggtacg ccttgtaata     2160

gctatggcaa ggatttggaa gacctcaagc tgcttgtgga atatcagact ggtgagtgtt     2220

ggcttgtgtg aatcaagagt tcctgactaa atgcttgctc agatgaacgg ttacatgtta     2280

tgatctacga tgccgacgag gaagtctatc aagttcctga atcagtcctt cctcgcgtgg     2340

gtagtgacga ggactctgag gacagtgttt tggaatttga ctatgtggaa gaaccgtttt     2400

cattcaccat ctccaaggga gatgaggtcc tgtttgactc ttcggcatca ccactagttt     2460

ttcagtcgca atatgtgaac cttcgcacct ggttgcccga tgatccctat gtgtatggtc     2520

tcggagagca ttctgaccct atgcgcttgc caacatacaa ttacacgcgg accctttgga     2580

accgcgacgc gtatggcact ccaaacaaca ccaacttgta cggtagtcat cctgtctact     2640

atgatcaccg tggaaagtcc ggaacttatg gagtcttcct gctgaactct aatggtatgg     2700

acatcaagat caaccaaacg acagatggaa agcagtactt ggaatacaat cttctcggcg     2760

gtgttctgga cttctacttc ttctacggag aagatcctaa gcaagcgagc atggaatact     2820

caaagattgt cggtctcccg gcaatgcaga gttactggac tttcggcgta tgccccccac     2880

cccctaatcc cataacagtc cgagttgtat gctgactctt cagttccatc aatgccgtta     2940

tggataccgc gatgtgtatg aacttgccga ggtggtctac aactacagcc aggcaaagat     3000

tcctctggag acgatgtgga cagatatcga ctacatggac aagagaaggg tgtttaccct     3060

tgatcctcag aggttcccgc tcgaaaagat gcgggagttg gtaacctacc tgcacaatca     3120

tgatcagcat tacattgtca tggttgaccc ggctgtgagc gtaagcagtg agtgacttga     3180

cgattcccca tccttgcaac tttcagctaa tggatacttt ctagataaca cggcatatat     3240

caccggcgtg agagacgatg ttttccttca caatcagaac ggtagcctat acgagggtaa     3300

gtatatacac atctcatatc tctcaacacg agctaaacta tgcaggtgct gtttggcctg     3360

gtgtcactgt tttcccagac tggttcaatg agggtactca ggattactgg actgcgcaat     3420

ttcaacagtt ctttgatccc aagtccggag tcgatattga cgccctgtgg attgacatga     3480

acgaagcctc caatttctgc ccttatcctt gtctggaccc agcggcatac gcgatctccg     3540

ccgacctccc accggcagca ccacctgttc ggccaagcag cccgatccca ctgcccggat     3600

tccccgcgga ctttcagcct tcgtctaagc gatctgttaa aagagcgcaa ggagataaag     3660

ggaagaaggt tgggttgccc aatcgcaacc tcactgaccc gccctacacc attcggaatg     3720

ccgcaggtgt ccttagtatg agcactatcg agacggatct cattcatgcg ggtgaagggt     3780

atgccgagta tgatactcac aatctctatg gaacaagtaa gtctttcaaa tatttgcata     3840

gatgatttgc cattgacagg gttagtgatg agctctgctt cccgcacggc tatgcaggcc     3900

cgccgtcccg atgtgaggcc tttggtcatc actcgcagta cgtttgcagg cgctggagca     3960

cacgtaggac actggtaagt tgaccgatag ccttcgctag cacatcgctg attcgtacag     4020

gctgggcgac aactttagcg attgggttca ctaccggatc tccatcgcgc agatcctctc     4080

cttcgcgtcc atgttccaga ttccaatggt cggggctgac gtgtgtgggt ttggtagcaa     4140

cacgacggag gaattgtgtg cccgatgggc gtcacttggt gccttctata cgttctaccg     4200

caatcataac gagctgggcg acatatcgca agagttctac cgctggccta cggttgccga     4260

gtccgcgcgt aaggccattg acatccggta caagctcctc gattatatct acactgctct     4320

tcaccggcaa agccagaccg gcgagccatt cctgcagcct caattctacc tgtaccctga     4380

ggattcgaac acctttgcga acgaccggca gttcttctat ggtgacgccc ttcttgtcag     4440

ccccgtgttg aatgagggat ccacctcagt cgacgcatac ttcccggacg acatcttcta     4500

cgattggtac acaggggcag tggtgcgtgg gcacggagaa aacatcacgc tcagcaacat     4560

caacatcacc cacatccctc tgcacatccg cggtggaaat atcatacctg tcaggacatc     4620

cagcggcatg acaaccactg aggttcgtaa gcagggcttc gagctgatca tcgcgccaga     4680

cttggatgac accgcatcgg gcagtctata tttggatgat ggagactcgt tgaacccgtc     4740

atctgtgaca gagctcgagt tcacgtacag caaaggggag ttgcacgtga agggtacatt     4800

cggacagaag gccgtcccca aggtggagaa atgtaccttg ctggggaagt cagcacggac     4860

gttcaagggc tttgcactcg atgcgccggt gaactttaag ctgaagtagt tagcatatcg     4920

agttggagtt cagatgagag gggggtaaaa agtagttagt gtctcaggta ccagatcgct     4980

tacatagtgc ccttactgct aattaagatg attgacatat ctcaataagc ataaactctg     5040

ccgcagcata cagcaagcac gtagccaggg gacaggcagg aaagccagtg gcaggggatc     5100

aagggatagg ataagggata cacaccaagg cagtaagcat tcaagccgcg ccaccacaaa     5160

gatactgtcc aatcctctcc agaggaagaa atgaccgcat aatacgcatc aagccatcca     5220

catttactcg ccacaccaca atctcataac tcacccaccc aacccaacct gctacataac     5280

acatgtacca cagtcaatac atacatacca tgtgccagcc gccatgcctc gaacccgcca     5340

cgcaagggat acagacaatc atcaaacaag gacgggaggc aggcaggacg cgtctacata     5400

ctacgcacgt accttgcaca tccgtctatc cctactacac gagtcaatcc ttatttccgg     5460

ggttattcaa atacctaacg gaatcacctc actagctagt aggatttcac catccacttc     5520

gtttcctctc tcgttttatc tttctctatt atcttgaagt aaaccggaac aatatgcatc     5580

tcaaatccat cctcttcacc ctcgccgcat cgactaccct tgtcgccgcc ggcagcgact     5640

actattgtct catggcgcag gacggcacgg gcatgatcca ggacccgtat tgctgcgata     5700

gtttctctga tacgccgggg gattcgattg ctaaagttgg gaagaattgt atgtttcagc     5760

ataccttgtg actgtccttt tttagtggtg ggtcaatgct gatgattgtg tgtttgtcgt     5820

tgtaggccag tcgatggatg gacttgagtg gacggatcag tgtcctcagg gtggaactgt     5880

gaagtgttgt tatactattg taagtaaaac accaccatca tgactgtcga agaattgcct     5940

cgactgggat atgtactaat gaagatgaat gtagggtccc cagttcatct gcacggcaga     6000

agcagaggag aacacggatg atgattgatt gattgatcta ctattccaca tcatggatgg     6060

gattatactt tactcgtcca catattcacc cacacaaagc aatgaagtat tcaaactatt     6120

gtacactaca cctattcctc ccacaccacc acgtctagct agtaaataaa ttaaataact     6180

ttaaacacta accatcctaa caaacctctc ccccaactcc tccgccgcca acggattcgc     6240

tcccgtcaac aactccctac aaagcgtcgt cttacccaac ttctcccttc ccccctctac     6300

catcacagcc ccagcatccc tcaactgact ctccaccttc tcaatctccc ccctcaacaa     6360

cgtctccata accttctcct ccgcatcact ccaacacgta atctcatacc ccttatacac     6420

gaactcccca tccccactaa ccctcgtact caacaacgcc aacggcccat gacaaatcgc     6480

cgccgtgggc ttattctccc catgaaagta cctcaggatc ctgcccagct ccttatcacc     6540

acctaggtct acgagcggcg catgtccgcc cgggatgaac accgccgcga aagtcttcaa     6600

ttcatcgtcg gagatgctag caaaggggcg cggtgaggag aagccgtttt cgcggcgcat     6660

gcgctcgatg agctcttgct cgcgccggcg ttcgtagaag ttgccggcga aggtgaggag     6720

ggattcgctg ttcgggtcgg gttgaggggt ttggcccttg ggagaggcga aggtgacttc     6780

gtggccggcc gagaggagtt tggagagtgg tttggcgagt tcggggagga agaagccggt     6840

tggttgttgt tgcgtgccgg aggaggtgtt gtgcaggggg aaggaggtcg cgtcgctgag     6900

gattatgag                                                             6909


<210>  6
<211>  2598
<212>  DNA
<213>  Aspergillus niger


<220>
<221>  misc_feature
<223>  AgdB cDNA

<400>  6
atgttggggt ctttgctttt actcttaccc cttgtgggcg ctgctgtcat tggacccagg       60

gcaaacagtc agagttgccc agggtataag gcgtccaacg tccaaaagca ggctaggtca      120

ctgactgcgg atctgactct agctggtacg ccttgtaata gctatggcaa ggatttggaa      180

gacctcaagc tgcttgtgga atatcagact gatgaacggt tacatgttat gatctacgat      240

gccgacgagg aagtctatca agttcctgaa tcagtccttc ctcgcgtggg tagtgacgag      300

gactctgagg acagtgtttt ggaatttgac tatgtggaag aaccgttttc attcaccatc      360

tccaagggag atgaggtcct gtttgactct tcggcatcac cactagtttt tcagtcgcaa      420

tatgtgaacc ttcgcacctg gttgcccgat gatccctatg tgtatggtct cggagagcat      480

tctgacccta tgcgcttgcc aacatacaat tacacgcgga ccctttggaa ccgcgacgcg      540

tatggcactc caaacaacac caacttgtac ggtagtcatc ctgtctacta tgatcaccgt      600

ggaaagtccg gaacttatgg agtcttcctg ctgaactcta atggtatgga catcaagatc      660

aaccaaacga cagatggaaa gcagtacttg gaatacaatc ttctcggcgg tgttctggac      720

ttctacttct tctacggaga agatcctaag caagcgagca tggaatactc aaagattgtc      780

ggtctcccgg caatgcagag ttactggact ttcggcgtat gccccccacc ccctaatccc      840

ataacagtcc gagttgtggt ctacaactac agccaggcaa agattcctct ggagacgatg      900

tggacagata tcgactacat ggacaagaga agggtgttta cccttgatcc tcagaggttc      960

ccgctcgaaa agatgcggga gttggtaacc tacctgcaca atcatgatca gcattacatt     1020

gtcatggttg acccggctgt gagcgtaagc aataacacgg catatatcac cggcgtgaga     1080

gacgatgttt tccttcacaa tcagaacggt agcctatacg agggtgctgt ttggcctggt     1140

gtcactgttt tcccagactg gttcaatgag ggtactcagg attactggac tgcgcaattt     1200

caacagttct ttgatcccaa gtccggagtc gatattgacg ccctgtggat tgacatgaac     1260

gaagcctcca atttctgccc ttatccttgt ctggacccag cggcatacgc gatctccgcc     1320

gacctcccac cggcagcacc acctgttcgg ccaagcagcc cgatcccact gcccggattc     1380

cccgcggact ttcagccttc gtctaagcga tctgttaaaa gagcgcaagg agataaaggg     1440

aagaaggttg ggttgcccaa tcgcaacctc actgacccgc cctacaccat tcggaatgcc     1500

gcaggtgtcc ttagtatgag cactatcgag acggatctca ttcatgcggg tgaagggtat     1560

gccgagtatg atactcacaa tctctatgga acaaggttag tgatgagctc tgcttcccgc     1620

acggctatgc aggcccgccg tcccgatgtg aggcctttgg tcatcactcg cagtacgttt     1680

gcaggcgctg gagcacacgt aggacactgg ctgggcgaca actttagcga ttgggttcac     1740

taccggatct ccatcgcgca gatcctctcc ttcgcgtcca tgttccagat tccaatggtc     1800

ggggctgacg tgtgtgggtt tggtagcaac acgacggagg aattgtgtgc ccgatgggcg     1860

tcacttggtg ccttctatac gttctaccgc aatcataacg agctgggcga catatcgcaa     1920

gagttctacc gctggcctac ggttgccgag tccgcgcgta aggccattga catccggtac     1980

aagctcctcg attatatcta cactgctctt caccggcaaa gccagaccgg cgagccattc     2040

ctgcagcctc aattctacct gtaccctgag gattcgaaca cctttgcgaa cgaccggcag     2100

ttcttctatg gtgacgccct tcttgtcagc cccgtgttga atgagggatc cacctcagtc     2160

gacgcatact tcccggacga catcttctac gattggtaca caggggcagt ggtgcgtggg     2220

cacggagaaa acatcacgct cagcaacatc aacatcaccc acatccctct gcacatccgc     2280

ggtggaaata tcatacctgt caggacatcc agcggcatga caaccactga ggttcgtaag     2340

cagggcttcg agctgatcat cgcgccagac ttggatgaca ccgcatcggg cagtctatat     2400

ttggatgatg gagactcgtt gaacccgtca tctgtgacag agctcgagtt cacgtacagc     2460

aaaggggagt tgcacgtgaa gggtacattc ggacagaagg ccgtccccaa ggtggagaaa     2520

tgtaccttgc tggggaagtc agcacggacg ttcaagggct ttgcactcga tgcgccggtg     2580

aactttaagc tgaagtag                                                   2598


<210>  7
<211>  865
<212>  PRT
<213>  Aspergillus niger


<220>
<221>  misc_feature
<223>  AgdB protein

<400>  7

Met Leu Gly Ser Leu Leu Leu Leu Leu Pro Leu Val Gly Ala Ala Val 
1               5                   10                  15      


Ile Gly Pro Arg Ala Asn Ser Gln Ser Cys Pro Gly Tyr Lys Ala Ser 
            20                  25                  30          


Asn Val Gln Lys Gln Ala Arg Ser Leu Thr Ala Asp Leu Thr Leu Ala 
        35                  40                  45              


Gly Thr Pro Cys Asn Ser Tyr Gly Lys Asp Leu Glu Asp Leu Lys Leu 
    50                  55                  60                  


Leu Val Glu Tyr Gln Thr Asp Glu Arg Leu His Val Met Ile Tyr Asp 
65                  70                  75                  80  


Ala Asp Glu Glu Val Tyr Gln Val Pro Glu Ser Val Leu Pro Arg Val 
                85                  90                  95      


Gly Ser Asp Glu Asp Ser Glu Asp Ser Val Leu Glu Phe Asp Tyr Val 
            100                 105                 110         


Glu Glu Pro Phe Ser Phe Thr Ile Ser Lys Gly Asp Glu Val Leu Phe 
        115                 120                 125             


Asp Ser Ser Ala Ser Pro Leu Val Phe Gln Ser Gln Tyr Val Asn Leu 
    130                 135                 140                 


Arg Thr Trp Leu Pro Asp Asp Pro Tyr Val Tyr Gly Leu Gly Glu His 
145                 150                 155                 160 


Ser Asp Pro Met Arg Leu Pro Thr Tyr Asn Tyr Thr Arg Thr Leu Trp 
                165                 170                 175     


Asn Arg Asp Ala Tyr Gly Thr Pro Asn Asn Thr Asn Leu Tyr Gly Ser 
            180                 185                 190         


His Pro Val Tyr Tyr Asp His Arg Gly Lys Ser Gly Thr Tyr Gly Val 
        195                 200                 205             


Phe Leu Leu Asn Ser Asn Gly Met Asp Ile Lys Ile Asn Gln Thr Thr 
    210                 215                 220                 


Asp Gly Lys Gln Tyr Leu Glu Tyr Asn Leu Leu Gly Gly Val Leu Asp 
225                 230                 235                 240 


Phe Tyr Phe Phe Tyr Gly Glu Asp Pro Lys Gln Ala Ser Met Glu Tyr 
                245                 250                 255     


Ser Lys Ile Val Gly Leu Pro Ala Met Gln Ser Tyr Trp Thr Phe Gly 
            260                 265                 270         


Val Cys Pro Pro Pro Pro Asn Pro Ile Thr Val Arg Val Val Val Tyr 
        275                 280                 285             


Asn Tyr Ser Gln Ala Lys Ile Pro Leu Glu Thr Met Trp Thr Asp Ile 
    290                 295                 300                 


Asp Tyr Met Asp Lys Arg Arg Val Phe Thr Leu Asp Pro Gln Arg Phe 
305                 310                 315                 320 


Pro Leu Glu Lys Met Arg Glu Leu Val Thr Tyr Leu His Asn His Asp 
                325                 330                 335     


Gln His Tyr Ile Val Met Val Asp Pro Ala Val Ser Val Ser Asn Asn 
            340                 345                 350         


Thr Ala Tyr Ile Thr Gly Val Arg Asp Asp Val Phe Leu His Asn Gln 
        355                 360                 365             


Asn Gly Ser Leu Tyr Glu Gly Ala Val Trp Pro Gly Val Thr Val Phe 
    370                 375                 380                 


Pro Asp Trp Phe Asn Glu Gly Thr Gln Asp Tyr Trp Thr Ala Gln Phe 
385                 390                 395                 400 


Gln Gln Phe Phe Asp Pro Lys Ser Gly Val Asp Ile Asp Ala Leu Trp 
                405                 410                 415     


Ile Asp Met Asn Glu Ala Ser Asn Phe Cys Pro Tyr Pro Cys Leu Asp 
            420                 425                 430         


Pro Ala Ala Tyr Ala Ile Ser Ala Asp Leu Pro Pro Ala Ala Pro Pro 
        435                 440                 445             


Val Arg Pro Ser Ser Pro Ile Pro Leu Pro Gly Phe Pro Ala Asp Phe 
    450                 455                 460                 


Gln Pro Ser Ser Lys Arg Ser Val Lys Arg Ala Gln Gly Asp Lys Gly 
465                 470                 475                 480 


Lys Lys Val Gly Leu Pro Asn Arg Asn Leu Thr Asp Pro Pro Tyr Thr 
                485                 490                 495     


Ile Arg Asn Ala Ala Gly Val Leu Ser Met Ser Thr Ile Glu Thr Asp 
            500                 505                 510         


Leu Ile His Ala Gly Glu Gly Tyr Ala Glu Tyr Asp Thr His Asn Leu 
        515                 520                 525             


Tyr Gly Thr Arg Leu Val Met Ser Ser Ala Ser Arg Thr Ala Met Gln 
    530                 535                 540                 


Ala Arg Arg Pro Asp Val Arg Pro Leu Val Ile Thr Arg Ser Thr Phe 
545                 550                 555                 560 


Ala Gly Ala Gly Ala His Val Gly His Trp Leu Gly Asp Asn Phe Ser 
                565                 570                 575     


Asp Trp Val His Tyr Arg Ile Ser Ile Ala Gln Ile Leu Ser Phe Ala 
            580                 585                 590         


Ser Met Phe Gln Ile Pro Met Val Gly Ala Asp Val Cys Gly Phe Gly 
        595                 600                 605             


Ser Asn Thr Thr Glu Glu Leu Cys Ala Arg Trp Ala Ser Leu Gly Ala 
    610                 615                 620                 


Phe Tyr Thr Phe Tyr Arg Asn His Asn Glu Leu Gly Asp Ile Ser Gln 
625                 630                 635                 640 


Glu Phe Tyr Arg Trp Pro Thr Val Ala Glu Ser Ala Arg Lys Ala Ile 
                645                 650                 655     


Asp Ile Arg Tyr Lys Leu Leu Asp Tyr Ile Tyr Thr Ala Leu His Arg 
            660                 665                 670         


Gln Ser Gln Thr Gly Glu Pro Phe Leu Gln Pro Gln Phe Tyr Leu Tyr 
        675                 680                 685             


Pro Glu Asp Ser Asn Thr Phe Ala Asn Asp Arg Gln Phe Phe Tyr Gly 
    690                 695                 700                 


Asp Ala Leu Leu Val Ser Pro Val Leu Asn Glu Gly Ser Thr Ser Val 
705                 710                 715                 720 


Asp Ala Tyr Phe Pro Asp Asp Ile Phe Tyr Asp Trp Tyr Thr Gly Ala 
                725                 730                 735     


Val Val Arg Gly His Gly Glu Asn Ile Thr Leu Ser Asn Ile Asn Ile 
            740                 745                 750         


Thr His Ile Pro Leu His Ile Arg Gly Gly Asn Ile Ile Pro Val Arg 
        755                 760                 765             


Thr Ser Ser Gly Met Thr Thr Thr Glu Val Arg Lys Gln Gly Phe Glu 
    770                 775                 780                 


Leu Ile Ile Ala Pro Asp Leu Asp Asp Thr Ala Ser Gly Ser Leu Tyr 
785                 790                 795                 800 


Leu Asp Asp Gly Asp Ser Leu Asn Pro Ser Ser Val Thr Glu Leu Glu 
                805                 810                 815     


Phe Thr Tyr Ser Lys Gly Glu Leu His Val Lys Gly Thr Phe Gly Gln 
            820                 825                 830         


Lys Ala Val Pro Lys Val Glu Lys Cys Thr Leu Leu Gly Lys Ser Ala 
        835                 840                 845             


Arg Thr Phe Lys Gly Phe Ala Leu Asp Ala Pro Val Asn Phe Lys Leu 
    850                 855                 860                 


Lys 
865 


<210>  8
<211>  7124
<212>  DNA
<213>  Aspergillus niger


<220>
<221>  misc_feature
<223>  AgdA genomic DNA including 2kb upstream and downstream flanking 
       regions

<400>  8
cagtccattg cttgtttaac ggattttgtg acgaattctg ttggtatgta ttctgttgtc       60

gtgataccag gggatgaatg ggcgcaagtg gatataaggt gcggaacttg gggcctttgc      120

gccggagcac atcactgtag gaacaagaaa gaagaaggcg tcgacactta tcgcagggaa      180

gctctctcga gcacttgatc ttacgccgac gacagttgtc gcaggcttgc ttggaggcct      240

tttgtttggt aggggaagga tgagagtcca tttgtatgcg gagacaagtg tgactcccgt      300

cagaacttag cagtagcagc ggcagtggag cgagactctg gagacttcat tgtattttga      360

gaaataacga tactcgtgag acaagtttcg gtggtcaaga tggccacaag gtgagcagtc      420

accgaaaatc atgcgattgc taaaggaggg gagaccaaag gagagaaatc tggggaaggg      480

cggcgggtaa gcgacaccgt gagaaagtcg gcacctccag gctacccgga ccccgcggta      540

tgagccacct ccattaacct gctacgactg gcctgttcat ttcggcccgt tgctcgagcc      600

aaagggggta tcacctcgac tggagctact agtcttttag tcccaggatg gcttcctggt      660

ttagcaggtg gaccctccgc ccgagccatg acgcgggtca ggtatactcc agacaggagg      720

ccgaagccat gtccttcaag tgcgagagaa gcgtaggctg aaccatgata tgtcacggag      780

ccatcatcac agatattgcc tcggtatatc cggtagacga ctcgaatcat ttagagactc      840

tttgcgtgta cgtggtgtgg gcatgccatg agttgttggg ccggcctgaa ggatccatca      900

ttgggaccaa gggcatcatc catgcgctac ggagtacttt cggagaatca gcacccctgc      960

acaaagcatt gtcaatgtgt tttcttatgt caaaagctga cagagtctga ggctcgctga     1020

cgatgggatt catgctaatg acggtccgaa agagctttca cgtaacactg gtgaacatcc     1080

cactcgggaa gccgagactt gtgacctact tagtcaaatg agatgattat caaagccatt     1140

aaatgcctcg ctgtcagggg ccctggtaag tgtcttcatt aatcgaaacc catcttcatt     1200

cgtccccgcc ttcagtgctc atcattttag gtttagaagc aagattgagt gccacctgct     1260

ttacaaacca gcatgggtag tctgctgttg aaattcttca ccgggagcat tctggggaag     1320

gtgcaaaagg cggcgcgaag tggtcgggtc gcgattgtag tctggattgg agcacaagaa     1380

tcgtcagagc cgaagcccga actgaggggg tctcggtcat ttatcgggat gagagccaat     1440

cagcgtgcgc tcatcatctg atcgtctggc tgccaggccc ctcaggcatc aatacggtac     1500

tcggcagtat ccactcccgt ttctccggtg caacaaatca tcgttggaga atccccagct     1560

cccccgccaa ctggggtcga tgcttctcca gttgtcctgg tttctcccat gaactcgctt     1620

acgataagct gctgtaccag cccaccagca caacaatatc ttcaatcagg taggtgcttg     1680

ttcgttacct gccccatcct ctcctcttct tcggtcatta tgaactcaat tcggtcgcta     1740

gctttgccga ttctccgcag tccataaaaa tatatctgca tttgcccctt acacgtcggg     1800

aattcaccgg cgcaatgagc cttcgggtat ggtcgcacag cgtcatgtca ataggaggct     1860

gctcctagtg gtgatctact agtcgcctca acacagcaat atataaataa caagagcatt     1920

ccttgagcac atctgggtaa tagctgttcc attctcatca aggattacgc gaccgtgcct     1980

cgagcctcct taagcgagcc atggtgaagt tgacgcatct ccttgccaga gcatggcttg     2040

tccctctggc ttatggagcg agccagtcac tcttatccac cactgcccct tcgcagccgc     2100

agtttaccat tcctgcttcc gcagatgtcg gtgcgcagct gattgccaac atcgatgatc     2160

ctcaggctgc cgacgcgcag tcggtttgtc cgggctacaa ggcttcaaaa gtgcagcaca     2220

attcacgtgg attcactgcc agtcttcagc tcgcgggcag gccatgtaac gtatacggca     2280

cagatgttga gtccttgaca ctgtctgtgg agtaccagga ttcggatcga ctgaatattc     2340

agattctccc cactcatgtt gactccacaa acgcttcttg gtactttctt tcggaaaacc     2400

tggtccccag acccaaggct tccctcaatg catctgtatc ccagagcgac ctttttgtgt     2460

catggtcaaa tgagccgtcg ttcaatttca aggtgatccg aaaggctaca ggcgacgcgc     2520

ttttcagtac agaaggcact gtgctcgtat atgagaatca gttcatcgaa tttgtgaccg     2580

cgctccctga agaatataac ttgtatggcc ttggggagca tatcacgcaa ttccgcctcc     2640

agagaaatgc taatctgacc atatatcctt cggatgatgg aacacctatt gaccagtgag     2700

tactgatatc ccgcccgtat cttctggttc tactcttgaa acttactcgt cctagaaacc     2760

tctacggcca acatcccttc tatctggata caagatatta caaaggagat aggcagaatg     2820

ggtcttatat tcccgtcaaa agcagcgagg ctgatgcctc gcaagattat atctccctct     2880

ctcatggcgt gtttctgagg aactctcatg gacttgagat actcctccgg tctcaaaaat     2940

tgatctggcg gaccctaggt ggaggaatcg atctcacctt ctactcaggc cccgccccgg     3000

ccgatgttac caggcaatat cttaccagca ctgtgggatt accggccatg cagcaataca     3060

acactcttgg attccaccaa tgtcgttggg gctacaacaa ctggtcggat ctggcggacg     3120

ttgttgcgaa ctttgagaag tttgagatcc cgttggaata tatctggtgc gtattgtact     3180

ggtttatggt atctcaaaac agtctaacag gcacttagga ccgatattga ctacatgcac     3240

ggatatcgca actttgacaa cgatcaacat cgcttttcct acagtgaggg cgatgaattt     3300

ctcagcaagc tacatgagag tggacgctac tatgtaccca ttgttgatgc ggcgctctac     3360

attcctaatc ccgaaaatgc ctctgatgcg taagtgtcta gtgacaaatt atattactgc     3420

ctgtatgcta attagcgata cagatacgct acgtatgaca gaggagctgc ggacgacgtc     3480

ttcctcaaga atcccgatgg tagcctctat attggagccg tttggccagg atatacagtc     3540

ttccccgatt ggcatcatcc caaggcagtt gacttctggg ctaacgagct tgttatctgg     3600

tcgaagaaag tggcgttcga tggtgtgtgg tacgacatgt ctgaagtttc atccttctgt     3660

gtcgggagct gtggcacagg taacctgact ctgaacccgg cacacccatc gtttcttctc     3720

cccggtgagc ctggtgatat catatatgat tacccagagg ctttcaatat caccaacgct     3780

acagaggcgg cgtcagcttc ggcgggagct tccagtcagg ctgcagcaac cgcgaccacc     3840

acgtcgactt cggtatcata tctgcggaca acgcccacgc ctggtgtccg caatgttgag     3900

cacccaccct atgtgatcaa ccatgaccaa gaaggccatg atctcagtgt ccatgcggtg     3960

tcgccgaatg caacgcatgt tgatggtgtt gaggagtatg atgtgcacgg tctctacgga     4020

catcaaggat tgaacgctac ctaccaaggt ctgcttgagg tctggtctca taagcggcgg     4080

ccatttatta ttggccgctc aaccttcgct ggctctggca aatgggcagg ccactggggc     4140

ggcgacaact attccaaatg gtggtccatg tactactcca tctcgcaagc cctctccttc     4200

tcacttttcg gcattccgat gtttggtgcg gacacctgtg ggtttaacgg aaactccgat     4260

gaggagctct gcaaccgatg gatgcaactg tccgcattct tcccattcta ccgaaaccac     4320

aatgagctct ccacaatccc acaggagcct tatcggtggg cttctgttat tgaagcaacc     4380

aagtccgcca tgagaattcg gtacgccatc ctaccttact tttatacgtt gtttgacctg     4440

gcccacacca cgggctccac tgtaatgcgc gcactttcct gggaattccc taatgaccca     4500

acattggctg cggttgagac tcaattcatg gttgggccgg ccatcatggt ggtcccggta     4560

ttggagcctc tggtcaatac ggtcaagggc gtattcccag gagttggaca tggcgaagtg     4620

tggtacgatt ggtacaccca ggctgcagtt gatgcgaagc ccggggtcaa cacgaccatt     4680

tcggcaccat tgggccacat cccagtttat gtacgaggtg gaaacatctt gccgatgcaa     4740

gagccggcat tgaccactcg tgaagcccgg caaaccccgt gggctttgct agctgcacta     4800

ggaagcaatg gaaccgcgtc ggggcagctc tatctcgatg atggagagag catctacccc     4860

aatgccaccc tccatgtgga cttcacggca tcgcggtcaa gcctgcgctc gtcggctcaa     4920

ggaagatgga aagagaggaa cccgcttgct aatgtgacgg tgctcggagt gaacaaggag     4980

ccctctgcgg tgaccctgaa tggacaggcc gtatttcccg ggtctgtcac gtacaattct     5040

acgtcccagg ttctctttgt tggggggctg caaaacttga cgaagggcgg cgcatgggcg     5100

gaaaactggg tattggaatg gtagtgtcag ccacaagcca ggtgtgcgcg tacagcatgc     5160

aacatgggaa cgatgctctg caatgtagct ctttggttat aattcaaaat tcaacttcca     5220

cctttgtttc accggcggcc acggcattcc tgcatgacta acgttctgta aatggacccg     5280

ataacaccca gcacgttgca gcagagaagg tactctctca cacgcactgc tctttatagt     5340

tgccgagacg gccgccgagg agaaaaccgc cggcctgtgg ccactattcg ctggaaggaa     5400

ccctgccagt cgaacacacc cgcccgtgat cgccaggggc cgatggattt ccccccgcat     5460

ccttgtcggt tcatgagtga agactttaaa tcccatctag ctgacggtcg ggtacatcaa     5520

taactggcag cctagtttcc aagacacgga gaagcatgta atcgctattt atagaatgct     5580

gggatcggac ccgtcgaatg gtcttccgat gggaagtgac aactcacatt gtcatgttgg     5640

ccttactcaa tccaacggga tctgacctgc tttggctaac ctagtataaa tcagcatgtc     5700

tctcctttga tacatcggat cgttcctcaa atatagttat atcttcgaaa aattgacaag     5760

aaggatgaca atctttctgt ttctggccat tttcgtggct acagctctgg cagccacgcc     5820

tgcagaatgg cgctcccagt cgatatattt cctgctcacc gatcgctttg cgcgaacgga     5880

taattctacc actgcttctt gtgacttgag cgctcgggtt agtcacagca tgttctagaa     5940

tctccaattg attcgctgac agatctagca atattgcggt ggatcctggc agggcatcat     6000

caatcaggtc ggtccgtcca tcgttgcagc actatctaca tcaacgtttg tttggcaaat     6060

taacatccat tagctggact atattcaagg aatgggcttt acagcgatct ggatcacacc     6120

cgtaactgca cagatccccc aagatactgg ttacggacag gcatatcacg gatactggca     6180

gcaggacgcg tgagatgcta cctctatcgc ccggatgaat gtatatcctt cttaccatgc     6240

agacagttat gccctgaact cccattatgg tacggcagac gatctcaaag ctctggcttc     6300

agctcttcac tcacggggca tgtatctcat ggtggacgtt gttgccaatc acatggtatg     6360

ttcttagcct cccacgggac cttagcttta tatctgacag cgatagggcc acaatggtac     6420

ggggagctct gtggactaca gtgtttatag gccatttaat tcgcaaaagt actttcacaa     6480

cctctgttgg atctctgatt acaataacca gacaaacgtt gaagactgct ggctaggcga     6540

taacaccgtt gccttgccgg atcttgatac taccagtacg gaggtgaaga atatgtggta     6600

tgactgggtc gagtctctcg tctctaacta ctccggtaat cctaccttta cttcgctatt     6660

ttctgcctct tatgagacaa agactaacaa atatcaagtc gacggcctcc gcgtagacac     6720

agtcaagaac gtacagaaga acttctggcc cggctacaac aatgcttcag gcgtgtactg     6780

tattggagaa gtcttcgatg gggacgcctc atacacctgt ccttatcagg aagacttgga     6840

cggagtcctt aattacccca tgtaagccct acatttaacc ccattgaatg cttgccaacg     6900

acttgcaata ggtactatcc actcctccgg gctttcgaat ccaccaacgg cagtatcagc     6960

gacctctata acatgatcaa caccgtgaaa tccacctgca gagattctac gcttctaggg     7020

accttcgtcg aaaaccacga taacccacgc tttgccaagt aagaatatcc tctccgagtt     7080

caccattaca aacacaagag ctcacctcag aagctacaca agcg                      7124


<210>  9
<211>  2958
<212>  DNA
<213>  Aspergillus niger


<220>
<221>  misc_feature
<223>  AgdA cDNA

<400>  9
atggtgaagt tgacgcatct ccttgccaga gcatggcttg tccctctggc ttatggagcg       60

agccagtcac tcttatccac cactgcccct tcgcagccgc agtttaccat tcctgcttcc      120

gcagatgtcg gtgcgcagct gattgccaac atcgatgatc ctcaggctgc cgacgcgcag      180

tcggtttgtc cgggctacaa ggcttcaaaa gtgcagcaca attcacgtgg attcactgcc      240

agtcttcagc tcgcgggcag gccatgtaac gtatacggca cagatgttga gtccttgaca      300

ctgtctgtgg agtaccagga ttcggatcga ctgaatattc agattctccc cactcatgtt      360

gactccacaa acgcttcttg gtactttctt tcggaaaacc tggtccccag acccaaggct      420

tccctcaatg catctgtatc ccagagcgac ctttttgtgt catggtcaaa tgagccgtcg      480

ttcaatttca aggtgatccg aaaggctaca ggcgacgcgc ttttcagtac agaaggcact      540

gtgctcgtat atgagaatca gttcatcgaa tttgtgaccg cgctccctga agaatataac      600

ttgtatggcc ttggggagca tatcacgcaa ttccgcctcc agagaaatgc taatctgacc      660

atatatcctt cggatgatgg aacacctatt gaccaaaacc tctacggcca acatcccttc      720

tatctggata caagatatta caaaggagat aggcagaatg ggtcttatat tcccgtcaaa      780

agcagcgagg ctgatgcctc gcaagattat atctccctct ctcatggcgt gtttctgagg      840

aactctcatg gacttgagat actcctccgg tctcaaaaat tgatctggcg gaccctaggt      900

ggaggaatcg atctcacctt ctactcaggc cccgccccgg ccgatgttac caggcaatat      960

cttaccagca ctgtgggatt accggccatg cagcaataca acactcttgg attccaccaa     1020

tgtcgttggg gctacaacaa ctggtcggat ctggcggacg ttgttgcgaa ctttgagaag     1080

tttgagatcc cgttggaata tatctggacc gatattgact acatgcacgg atatcgcaac     1140

tttgacaacg atcaacatcg cttttcctac agtgagggcg atgaatttct cagcaagcta     1200

catgagagtg gacgctacta tgtacccatt gttgatgcgg cgctctacat tcctaatccc     1260

gaaaatgcct ctgatgcata cgctacgtat gacagaggag ctgcggacga cgtcttcctc     1320

aagaatcccg atggtagcct ctatattgga gccgtttggc caggatatac agtcttcccc     1380

gattggcatc atcccaaggc agttgacttc tgggctaacg agcttgttat ctggtcgaag     1440

aaagtggcgt tcgatggtgt gtggtacgac atgtctgaag tttcatcctt ctgtgtcggg     1500

agctgtggca caggtaacct gactctgaac ccggcacacc catcgtttct tctccccggt     1560

gagcctggtg atatcatata tgattaccca gaggctttca atatcaccaa cgctacagag     1620

gcggcgtcag cttcggcggg agcttccagt caggctgcag caaccgcgac caccacgtcg     1680

acttcggtat catatctgcg gacaacgccc acgcctggtg tccgcaatgt tgagcaccca     1740

ccctatgtga tcaaccatga ccaagaaggc catgatctca gtgtccatgc ggtgtcgccg     1800

aatgcaacgc atgttgatgg tgttgaggag tatgatgtgc acggtctcta cggacatcaa     1860

ggattgaacg ctacctacca aggtctgctt gaggtctggt ctcataagcg gcggccattt     1920

attattggcc gctcaacctt cgctggctct ggcaaatggg caggccactg gggcggcgac     1980

aactattcca aatggtggtc catgtactac tccatctcgc aagccctctc cttctcactt     2040

ttcggcattc cgatgtttgg tgcggacacc tgtgggttta acggaaactc cgatgaggag     2100

ctctgcaacc gatggatgca actgtccgca ttcttcccat tctaccgaaa ccacaatgag     2160

ctctccacaa tcccacagga gccttatcgg tgggcttctg ttattgaagc aaccaagtcc     2220

gccatgagaa ttcggtacgc catcctacct tacttttata cgttgtttga cctggcccac     2280

accacgggct ccactgtaat gcgcgcactt tcctgggaat tccctaatga cccaacattg     2340

gctgcggttg agactcaatt catggttggg ccggccatca tggtggtccc ggtattggag     2400

cctctggtca atacggtcaa gggcgtattc ccaggagttg gacatggcga agtgtggtac     2460

gattggtaca cccaggctgc agttgatgcg aagcccgggg tcaacacgac catttcggca     2520

ccattgggcc acatcccagt ttatgtacga ggtggaaaca tcttgccgat gcaagagccg     2580

gcattgacca ctcgtgaagc ccggcaaacc ccgtgggctt tgctagctgc actaggaagc     2640

aatggaaccg cgtcggggca gctctatctc gatgatggag agagcatcta ccccaatgcc     2700

accctccatg tggacttcac ggcatcgcgg tcaagcctgc gctcgtcggc tcaaggaaga     2760

tggaaagaga ggaacccgct tgctaatgtg acggtgctcg gagtgaacaa ggagccctct     2820

gcggtgaccc tgaatggaca ggccgtattt cccgggtctg tcacgtacaa ttctacgtcc     2880

caggttctct ttgttggggg gctgcaaaac ttgacgaagg gcggcgcatg ggcggaaaac     2940

tgggtattgg aatggtag                                                   2958


<210>  10
<211>  985
<212>  PRT
<213>  Aspergillus niger


<220>
<221>  misc_feature
<223>  AgdA protein

<400>  10

Met Val Lys Leu Thr His Leu Leu Ala Arg Ala Trp Leu Val Pro Leu 
1               5                   10                  15      


Ala Tyr Gly Ala Ser Gln Ser Leu Leu Ser Thr Thr Ala Pro Ser Gln 
            20                  25                  30          


Pro Gln Phe Thr Ile Pro Ala Ser Ala Asp Val Gly Ala Gln Leu Ile 
        35                  40                  45              


Ala Asn Ile Asp Asp Pro Gln Ala Ala Asp Ala Gln Ser Val Cys Pro 
    50                  55                  60                  


Gly Tyr Lys Ala Ser Lys Val Gln His Asn Ser Arg Gly Phe Thr Ala 
65                  70                  75                  80  


Ser Leu Gln Leu Ala Gly Arg Pro Cys Asn Val Tyr Gly Thr Asp Val 
                85                  90                  95      


Glu Ser Leu Thr Leu Ser Val Glu Tyr Gln Asp Ser Asp Arg Leu Asn 
            100                 105                 110         


Ile Gln Ile Leu Pro Thr His Val Asp Ser Thr Asn Ala Ser Trp Tyr 
        115                 120                 125             


Phe Leu Ser Glu Asn Leu Val Pro Arg Pro Lys Ala Ser Leu Asn Ala 
    130                 135                 140                 


Ser Val Ser Gln Ser Asp Leu Phe Val Ser Trp Ser Asn Glu Pro Ser 
145                 150                 155                 160 


Phe Asn Phe Lys Val Ile Arg Lys Ala Thr Gly Asp Ala Leu Phe Ser 
                165                 170                 175     


Thr Glu Gly Thr Val Leu Val Tyr Glu Asn Gln Phe Ile Glu Phe Val 
            180                 185                 190         


Thr Ala Leu Pro Glu Glu Tyr Asn Leu Tyr Gly Leu Gly Glu His Ile 
        195                 200                 205             


Thr Gln Phe Arg Leu Gln Arg Asn Ala Asn Leu Thr Ile Tyr Pro Ser 
    210                 215                 220                 


Asp Asp Gly Thr Pro Ile Asp Gln Asn Leu Tyr Gly Gln His Pro Phe 
225                 230                 235                 240 


Tyr Leu Asp Thr Arg Tyr Tyr Lys Gly Asp Arg Gln Asn Gly Ser Tyr 
                245                 250                 255     


Ile Pro Val Lys Ser Ser Glu Ala Asp Ala Ser Gln Asp Tyr Ile Ser 
            260                 265                 270         


Leu Ser His Gly Val Phe Leu Arg Asn Ser His Gly Leu Glu Ile Leu 
        275                 280                 285             


Leu Arg Ser Gln Lys Leu Ile Trp Arg Thr Leu Gly Gly Gly Ile Asp 
    290                 295                 300                 


Leu Thr Phe Tyr Ser Gly Pro Ala Pro Ala Asp Val Thr Arg Gln Tyr 
305                 310                 315                 320 


Leu Thr Ser Thr Val Gly Leu Pro Ala Met Gln Gln Tyr Asn Thr Leu 
                325                 330                 335     


Gly Phe His Gln Cys Arg Trp Gly Tyr Asn Asn Trp Ser Asp Leu Ala 
            340                 345                 350         


Asp Val Val Ala Asn Phe Glu Lys Phe Glu Ile Pro Leu Glu Tyr Ile 
        355                 360                 365             


Trp Thr Asp Ile Asp Tyr Met His Gly Tyr Arg Asn Phe Asp Asn Asp 
    370                 375                 380                 


Gln His Arg Phe Ser Tyr Ser Glu Gly Asp Glu Phe Leu Ser Lys Leu 
385                 390                 395                 400 


His Glu Ser Gly Arg Tyr Tyr Val Pro Ile Val Asp Ala Ala Leu Tyr 
                405                 410                 415     


Ile Pro Asn Pro Glu Asn Ala Ser Asp Ala Tyr Ala Thr Tyr Asp Arg 
            420                 425                 430         


Gly Ala Ala Asp Asp Val Phe Leu Lys Asn Pro Asp Gly Ser Leu Tyr 
        435                 440                 445             


Ile Gly Ala Val Trp Pro Gly Tyr Thr Val Phe Pro Asp Trp His His 
    450                 455                 460                 


Pro Lys Ala Val Asp Phe Trp Ala Asn Glu Leu Val Ile Trp Ser Lys 
465                 470                 475                 480 


Lys Val Ala Phe Asp Gly Val Trp Tyr Asp Met Ser Glu Val Ser Ser 
                485                 490                 495     


Phe Cys Val Gly Ser Cys Gly Thr Gly Asn Leu Thr Leu Asn Pro Ala 
            500                 505                 510         


His Pro Ser Phe Leu Leu Pro Gly Glu Pro Gly Asp Ile Ile Tyr Asp 
        515                 520                 525             


Tyr Pro Glu Ala Phe Asn Ile Thr Asn Ala Thr Glu Ala Ala Ser Ala 
    530                 535                 540                 


Ser Ala Gly Ala Ser Ser Gln Ala Ala Ala Thr Ala Thr Thr Thr Ser 
545                 550                 555                 560 


Thr Ser Val Ser Tyr Leu Arg Thr Thr Pro Thr Pro Gly Val Arg Asn 
                565                 570                 575     


Val Glu His Pro Pro Tyr Val Ile Asn His Asp Gln Glu Gly His Asp 
            580                 585                 590         


Leu Ser Val His Ala Val Ser Pro Asn Ala Thr His Val Asp Gly Val 
        595                 600                 605             


Glu Glu Tyr Asp Val His Gly Leu Tyr Gly His Gln Gly Leu Asn Ala 
    610                 615                 620                 


Thr Tyr Gln Gly Leu Leu Glu Val Trp Ser His Lys Arg Arg Pro Phe 
625                 630                 635                 640 


Ile Ile Gly Arg Ser Thr Phe Ala Gly Ser Gly Lys Trp Ala Gly His 
                645                 650                 655     


Trp Gly Gly Asp Asn Tyr Ser Lys Trp Trp Ser Met Tyr Tyr Ser Ile 
            660                 665                 670         


Ser Gln Ala Leu Ser Phe Ser Leu Phe Gly Ile Pro Met Phe Gly Ala 
        675                 680                 685             


Asp Thr Cys Gly Phe Asn Gly Asn Ser Asp Glu Glu Leu Cys Asn Arg 
    690                 695                 700                 


Trp Met Gln Leu Ser Ala Phe Phe Pro Phe Tyr Arg Asn His Asn Glu 
705                 710                 715                 720 


Leu Ser Thr Ile Pro Gln Glu Pro Tyr Arg Trp Ala Ser Val Ile Glu 
                725                 730                 735     


Ala Thr Lys Ser Ala Met Arg Ile Arg Tyr Ala Ile Leu Pro Tyr Phe 
            740                 745                 750         


Tyr Thr Leu Phe Asp Leu Ala His Thr Thr Gly Ser Thr Val Met Arg 
        755                 760                 765             


Ala Leu Ser Trp Glu Phe Pro Asn Asp Pro Thr Leu Ala Ala Val Glu 
    770                 775                 780                 


Thr Gln Phe Met Val Gly Pro Ala Ile Met Val Val Pro Val Leu Glu 
785                 790                 795                 800 


Pro Leu Val Asn Thr Val Lys Gly Val Phe Pro Gly Val Gly His Gly 
                805                 810                 815     


Glu Val Trp Tyr Asp Trp Tyr Thr Gln Ala Ala Val Asp Ala Lys Pro 
            820                 825                 830         


Gly Val Asn Thr Thr Ile Ser Ala Pro Leu Gly His Ile Pro Val Tyr 
        835                 840                 845             


Val Arg Gly Gly Asn Ile Leu Pro Met Gln Glu Pro Ala Leu Thr Thr 
    850                 855                 860                 


Arg Glu Ala Arg Gln Thr Pro Trp Ala Leu Leu Ala Ala Leu Gly Ser 
865                 870                 875                 880 


Asn Gly Thr Ala Ser Gly Gln Leu Tyr Leu Asp Asp Gly Glu Ser Ile 
                885                 890                 895     


Tyr Pro Asn Ala Thr Leu His Val Asp Phe Thr Ala Ser Arg Ser Ser 
            900                 905                 910         


Leu Arg Ser Ser Ala Gln Gly Arg Trp Lys Glu Arg Asn Pro Leu Ala 
        915                 920                 925             


Asn Val Thr Val Leu Gly Val Asn Lys Glu Pro Ser Ala Val Thr Leu 
    930                 935                 940                 


Asn Gly Gln Ala Val Phe Pro Gly Ser Val Thr Tyr Asn Ser Thr Ser 
945                 950                 955                 960 


Gln Val Leu Phe Val Gly Gly Leu Gln Asn Leu Thr Lys Gly Gly Ala 
                965                 970                 975     


Trp Ala Glu Asn Trp Val Leu Glu Trp 
            980                 985 


<210>  11
<211>  1816
<212>  DNA
<213>  Artificial sequence

<220>
<223>  codon optimised cDNA of Penicillium Chrysogenum glucose oxidase

<400>  11
atgaagtcca ctattatcac ctccattctc ttctctgtgg ctgccgtcca ggcctatagc       60

ccggccgagc agatcgacgt ccagtctcac ctgctttctg accccaccaa ggtcgaggga      120

gagacttacg actatgtcat tgctggtggt ggtttgactg gtctgaccgt ggctgccaag      180

ctgtctgaaa acccgaagat caaagtcctt gtgattgaga agggattcta cgaatccaac      240

gatggaccga tcatcgagga ccccaacgcc tatggggaga tctttggaac tagtgtggat      300

cagaattatc tcacagttcc cctcatcaac aaccgaactg gggaaattaa gtctggcctc      360

ggtcttggtg gctcgacctt gatcaacggc gattcctgga cccgccccga caaggtccag      420

atcgactcat gggaaaaggt ctttggcatg gagggctgga actgggacaa tgtcttccag      480

tacatgcaga aagctgagcg ctcgcgcccc ccgactgccg cccagattga agccggtcac      540

ttctacgacc ctgcctgtca tggaacagac ggaaccgttc atgccggccc tcgcgacaac      600

ggcaagcctt ggtccccact gatgcgagcc ctcatgaaca ccgtctccgc tttcggtgtc      660

cccgtccaga aggacttcca ctgcggtcac ccccgtggtg tctcgatgat cccgaacaac      720

ctccatgaga accagatccg ggctgatgcc gctcgcgaat ggcttcttcc caactaccag      780

cgcgataacc tgcagatcct gactggccag aaggtcggaa aggttttgtt caaccagacc      840

gcatctggac ctaaggctgt tggtgtgaac ttcggtacca acaaggctgt taacttcaat      900

gtctacgcca agcaagaagt tctgttggcc gccggatctg ccatttctcc tttgatcctt      960

gaatactccg gtattggtat caagtccgtc cttgacaagg ccggtgttaa gcagctcctc     1020

gaactccctg ttggtctcaa catgcaagac cagaccacta ccactgttcg gtcccgcgcc     1080

aacaacgcac ctggacaagg ccaggccgct tactttgcca acttcaccga ggttctcggc     1140

gaccacgccg cccagggtat taagttgctg gacaccaagc ttgaccagtg ggccgaggag     1200

accgttgccc gcggtggctt ccacaatgtg actgccctca agatccagta tgagaactac     1260

cgtaactggc tccttgatga ggacgttgca tttgccgagc tcttcttcga cactgagggc     1320

aagatcaact ttgatatctg gaatcttatc cccttcactc gcggttccgt ccacatcctc     1380

agcagtgacc cttacctctg gcaatacgca aatgacccca agttcttcat gaacgagctg     1440

gatcttctcg gccaggccgc tgctactaag ctgggtcgtg agctctctag cgctggtgag     1500

atgaagaagt actacgctgg cgagaccatc cccggcgaca acctgcccca ggatgccacc     1560

gtcgagcagt gggaggacta cgtgatgatg aacttccgtc ctaactggca cgctgttagc     1620

acctgctcta tgatgtcccg cgagcttggt ggtgtcgtcg acgctactgc caaggtctac     1680

ggtactcagg gcctccgtgt cattgacgga tctatccctc ccactcaggt gtcctctcac     1740

gttatgaccg ttttctacgg tatggccttg cggatcgccg aatccgtcct tgaagactat     1800

gccaagaaag cttaaa                                                     1816


<210>  12
<211>  604
<212>  PRT
<213>  Penicillium chrysogenum


<220>
<221>  misc_feature
<223>  Glucose oxidase protein

<400>  12

Met Lys Ser Thr Ile Ile Thr Ser Ile Leu Phe Ser Val Ala Ala Val 
1               5                   10                  15      


Gln Ala Tyr Ser Pro Ala Glu Gln Ile Asp Val Gln Ser His Leu Leu 
            20                  25                  30          


Ser Asp Pro Thr Lys Val Glu Gly Glu Thr Tyr Asp Tyr Val Ile Ala 
        35                  40                  45              


Gly Gly Gly Leu Thr Gly Leu Thr Val Ala Ala Lys Leu Ser Glu Asn 
    50                  55                  60                  


Pro Lys Ile Lys Val Leu Val Ile Glu Lys Gly Phe Tyr Glu Ser Asn 
65                  70                  75                  80  


Asp Gly Pro Ile Ile Glu Asp Pro Asn Ala Tyr Gly Glu Ile Phe Gly 
                85                  90                  95      


Thr Ser Val Asp Gln Asn Tyr Leu Thr Val Pro Leu Ile Asn Asn Arg 
            100                 105                 110         


Thr Gly Glu Ile Lys Ser Gly Leu Gly Leu Gly Gly Ser Thr Leu Ile 
        115                 120                 125             


Asn Gly Asp Ser Trp Thr Arg Pro Asp Lys Val Gln Ile Asp Ser Trp 
    130                 135                 140                 


Glu Lys Val Phe Gly Met Glu Gly Trp Asn Trp Asp Asn Val Phe Gln 
145                 150                 155                 160 


Tyr Met Gln Lys Ala Glu Arg Ser Arg Pro Pro Thr Ala Ala Gln Ile 
                165                 170                 175     


Glu Ala Gly His Phe Tyr Asp Pro Ala Cys His Gly Thr Asp Gly Thr 
            180                 185                 190         


Val His Ala Gly Pro Arg Asp Asn Gly Lys Pro Trp Ser Pro Leu Met 
        195                 200                 205             


Arg Ala Leu Met Asn Thr Val Ser Ala Phe Gly Val Pro Val Gln Lys 
    210                 215                 220                 


Asp Phe His Cys Gly His Pro Arg Gly Val Ser Met Ile Pro Asn Asn 
225                 230                 235                 240 


Leu His Glu Asn Gln Ile Arg Ala Asp Ala Ala Arg Glu Trp Leu Leu 
                245                 250                 255     


Pro Asn Tyr Gln Arg Asp Asn Leu Gln Ile Leu Thr Gly Gln Lys Val 
            260                 265                 270         


Gly Lys Val Leu Phe Asn Gln Thr Ala Ser Gly Pro Lys Ala Val Gly 
        275                 280                 285             


Val Asn Phe Gly Thr Asn Lys Ala Val Asn Phe Asn Val Tyr Ala Lys 
    290                 295                 300                 


Gln Glu Val Leu Leu Ala Ala Gly Ser Ala Ile Ser Pro Leu Ile Leu 
305                 310                 315                 320 


Glu Tyr Ser Gly Ile Gly Ile Lys Ser Val Leu Asp Lys Ala Gly Val 
                325                 330                 335     


Lys Gln Leu Leu Glu Leu Pro Val Gly Leu Asn Met Gln Asp Gln Thr 
            340                 345                 350         


Thr Thr Thr Val Arg Ser Arg Ala Asn Asn Ala Pro Gly Gln Gly Gln 
        355                 360                 365             


Ala Ala Tyr Phe Ala Asn Phe Thr Glu Val Leu Gly Asp His Ala Ala 
    370                 375                 380                 


Gln Gly Ile Lys Leu Leu Asp Thr Lys Leu Asp Gln Trp Ala Glu Glu 
385                 390                 395                 400 


Thr Val Ala Arg Gly Gly Phe His Asn Val Thr Ala Leu Lys Ile Gln 
                405                 410                 415     


Tyr Glu Asn Tyr Arg Asn Trp Leu Leu Asp Glu Asp Val Ala Phe Ala 
            420                 425                 430         


Glu Leu Phe Phe Asp Thr Glu Gly Lys Ile Asn Phe Asp Ile Trp Asn 
        435                 440                 445             


Leu Ile Pro Phe Thr Arg Gly Ser Val His Ile Leu Ser Ser Asp Pro 
    450                 455                 460                 


Tyr Leu Trp Gln Tyr Ala Asn Asp Pro Lys Phe Phe Met Asn Glu Leu 
465                 470                 475                 480 


Asp Leu Leu Gly Gln Ala Ala Ala Thr Lys Leu Gly Arg Glu Leu Ser 
                485                 490                 495     


Ser Ala Gly Glu Met Lys Lys Tyr Tyr Ala Gly Glu Thr Ile Pro Gly 
            500                 505                 510         


Asp Asn Leu Pro Gln Asp Ala Thr Val Glu Gln Trp Glu Asp Tyr Val 
        515                 520                 525             


Met Met Asn Phe Arg Pro Asn Trp His Ala Val Ser Thr Cys Ser Met 
    530                 535                 540                 


Met Ser Arg Glu Leu Gly Gly Val Val Asp Ala Thr Ala Lys Val Tyr 
545                 550                 555                 560 


Gly Thr Gln Gly Leu Arg Val Ile Asp Gly Ser Ile Pro Pro Thr Gln 
                565                 570                 575     


Val Ser Ser His Val Met Thr Val Phe Tyr Gly Met Ala Leu Arg Ile 
            580                 585                 590         


Ala Glu Ser Val Leu Glu Asp Tyr Ala Lys Lys Ala 
        595                 600                 


<210>  13
<211>  5932
<212>  DNA
<213>  Aspergillus niger


<220>
<221>  misc_feature
<223>  AmyC genomic DNA including 2kb upstream and downstream flanking 
       regions

<400>  13
caatatcacc aacgctacag aggcggcgtc agcttcggcg ggagcttcca gtcaggctgc       60

agcaaccgcg accaccacgt cgacttcggt atcatatctg cggacaacgc ccacgcctgg      120

tgtccgcaat gttgagcacc caccctatgt gatcaaccat gaccaagaag gccatgatct      180

cagtgtccat gcggtgtcgc cgaatgcaac gcatgttgat ggtgttgagg agtatgatgt      240

gcacggtctc tacggacatc aaggattgaa cgctacctac caaggtctgc ttgaggtctg      300

gtctcataag cggcggccat ttattattgg ccgctcaacc ttcgctggct ctggcaaatg      360

ggcaggccac tggggcggcg acaactattc caaatggtgg tccatgtact actccatctc      420

gcaagccctc tccttctcac ttttcggcat tccgatgttt ggtgcggaca cctgtgggtt      480

taacggaaac tccgatgagg agctctgcaa ccgatggatg caactgtccg cattcttccc      540

attctaccga aaccacaatg agctctccac aatcccacag gagccttatc ggtgggcttc      600

tgttattgaa gcaaccaagt ccgccatgag aattcggtac gccatcctac cttactttta      660

tacgttgttt gacctggccc acaccacggg ctccactgta atgcgcgcac tttcctggga      720

attccctaat gacccaacat tggctgcggt tgagactcaa ttcatggttg ggccggccat      780

catggtggtc ccggtattgg agcctctggt caatacggtc aagggcgtat tcccaggagt      840

tggacatggc gaagtgtggt acgattggta cacccaggct gcagttgatg cgaagcccgg      900

ggtcaacacg accatttcgg caccattggg ccacatccca gtttatgtac gaggtggaaa      960

catcttgccg atgcaagagc cggcattgac cactcgtgaa gcccggcaaa ccccgtgggc     1020

tttgctagct gcactaggaa gcaatggaac cgcgtcgggg cagctctatc tcgatgatgg     1080

agagagcatc taccccaatg ccaccctcca tgtggacttc acggcatcgc ggtcaagcct     1140

gcgctcgtcg gctcaaggaa gatggaaaga gaggaacccg cttgctaatg tgacggtgct     1200

cggagtgaac aaggagccct ctgcggtgac cctgaatgga caggccgtat ttcccgggtc     1260

tgtcacgtac aattctacgt cccaggttct ctttgttggg gggctgcaaa acttgacgaa     1320

gggcggcgca tgggcggaaa actgggtatt ggaatggtag tgtcagccac aagccaggtg     1380

tgcgcgtaca gcatgcaaca tgggaacgat gctctgcaat gtagctcttt ggttataatt     1440

caaaattcaa cttccacctt tgtttcaccg gcggccacgg cattcctgca tgactaacgt     1500

tctgtaaatg gacccgataa cacccagcac gttgcagcag agaaggtact ctctcacacg     1560

cactgctctt tatagttgcc gagacggccg ccgaggagaa aaccgccggc ctgtggccac     1620

tattcgctgg aaggaaccct gccagtcgaa cacacccgcc cgtgatcgcc aggggccgat     1680

ggatttcccc ccgcatcctt gtcggttcat gagtgaagac tttaaatccc atctagctga     1740

cggtcgggta catcaataac tggcagccta gtttccaaga cacggagaag catgtaatcg     1800

ctatttatag aatgctggga tcggacccgt cgaatggtct tccgatggga agtgacaact     1860

cacattgtca tgttggcctt actcaatcca acgggatctg acctgctttg gctaacctag     1920

tataaatcag catgtctctc ctttgataca tcggatcgtt cctcaaatat agttatatct     1980

tcgaaaaatt gacaagaagg atgacaatct ttctgtttct ggccattttc gtggctacag     2040

ctctggcagc cacgcctgca gaatggcgct cccagtcgat atatttcctg ctcaccgatc     2100

gctttgcgcg aacggataat tctaccactg cttcttgtga cttgagcgct cgggttagtc     2160

acagcatgtt ctagaatctc caattgattc gctgacagat ctagcaatat tgcggtggat     2220

cctggcaggg catcatcaat caggtcggtc cgtccatcgt tgcagcacta tctacatcaa     2280

cgtttgtttg gcaaattaac atccattagc tggactatat tcaaggaatg ggctttacag     2340

cgatctggat cacacccgta actgcacaga tcccccaaga tactggttac ggacaggcat     2400

atcacggata ctggcagcag gacgcgtgag atgctacctc tatcgcccgg atgaatgtat     2460

atccttctta ccatgcagac agttatgccc tgaactccca ttatggtacg gcagacgatc     2520

tcaaagctct ggcttcagct cttcactcac ggggcatgta tctcatggtg gacgttgttg     2580

ccaatcacat ggtatgttct tagcctccca cgggacctta gctttatatc tgacagcgat     2640

agggccacaa tggtacgggg agctctgtgg actacagtgt ttataggcca tttaattcgc     2700

aaaagtactt tcacaacctc tgttggatct ctgattacaa taaccagaca aacgttgaag     2760

actgctggct aggcgataac accgttgcct tgccggatct tgatactacc agtacggagg     2820

tgaagaatat gtggtatgac tgggtcgagt ctctcgtctc taactactcc ggtaatccta     2880

cctttacttc gctattttct gcctcttatg agacaaagac taacaaatat caagtcgacg     2940

gcctccgcgt agacacagtc aagaacgtac agaagaactt ctggcccggc tacaacaatg     3000

cttcaggcgt gtactgtatt ggagaagtct tcgatgggga cgcctcatac acctgtcctt     3060

atcaggaaga cttggacgga gtccttaatt accccatgta agccctacat ttaaccccat     3120

tgaatgcttg ccaacgactt gcaataggta ctatccactc ctccgggctt tcgaatccac     3180

caacggcagt atcagcgacc tctataacat gatcaacacc gtgaaatcca cctgcagaga     3240

ttctacgctt ctagggacct tcgtcgaaaa ccacgataac ccacgctttg ccaagtaaga     3300

atatcctctc cgagttcacc attacaaaca caagagctca cctcagaagc tacacaagcg     3360

acatgtccct agccaaaaat gccgcaacat tcactatcct ggctgacggc attcccatca     3420

tatacgccgg tcaggaacag cactatagcg gcggtaatga cccctacaac cgcgaagcga     3480

cctggctttc aggctacaag accaccagcg agctctacac ccatatcgcc gcatcgaaca     3540

agattcgcac ccacgctata aaacaggata ccggatatct cacctacaaa gtaatcttca     3600

ttcgagtcca tgtgtggtac aatctatctg actagaacct attctagaac taccccatct     3660

accaagacac ctcgaccctt gccatgcgca aaggctacaa tggcacccaa actatcacgg     3720

tcctttctaa ccttggcgcc tcggggtcct catacacact ctccctccca ggaacaggct     3780

acacagccgg ccaaaagatt actgaaatct atacctgcac gaatctaaca gtcaactcaa     3840

atggctcggt gccagtaccc atgaagagcg ggttaccgcg gatcctctat cctgcagata     3900

agttggttaa tggaagctca ttttgcagtt agttccctgc ctatatgttt caataagccg     3960

tatttgcatg cgcgtccatc gcattgattc tttatggatt gatcaactga tacattcgca     4020

caggctctgc gatcactgtt ttcaaggatg caggaggagg cgtgttgttc tttagctaca     4080

ctgtgtaagt gtatcagatc atatcatggc cactagacga tgacccctgt gatcgtgatc     4140

cagatgctga cttcaatttg tagaattttc gctcaggtgc ttattgctat aatgacgtga     4200

ttaggatgtc tcagatgaca gtatatatta ttaggtgacg tgatgattct atgtgtaatg     4260

gattcttcaa gatcatttta tattattagt atccacagta ttcatttgcc tgcaaagtaa     4320

gtatggataa aatcactacc accgacgtag tagttgtacc tagtccttag tgtctcaaag     4380

ccacagtcac tacaacctca cgaaacgacg gagtaaactt atttctattg acacccagcc     4440

aataccaaca acagcagacc aatagtaaat tcaacctcaa cctctgcatc atacaaacat     4500

actagagaaa tatacttcat cataaaaaaa gaaaaggaaa gaaaagaaac aaaaacccct     4560

acttatctcc atcaagtatc tacatccgaa cccaaccatc tacgggcggg gcaagcgaga     4620

tgaacaacac ctcctactgc ctgcagcata gtagcatcat cccgtcaatt tccttccaaa     4680

agttacacct acattcacag caacataaca atacccaact cccctaccct cctctccaag     4740

ttttaattaa tccagataat taattggaga gaaaagttta tttctctaat cccgtccccc     4800

ctctccttcc tctcctcatc atgaaaagat aactaactag caatgatcga cttaataatt     4860

ctcggcggca tcctccggct cccacccact cactttcctc tcctcggcaa ctggttagat     4920

agttacttac tactatgtgc agtcaacgga tagtggagta aaggggtcaa agacatacta     4980

ctactactac ttagtctacc tgaacgtttt tgtttggtcg atcggagaaa taaacatctt     5040

gtcttcgatg aatgattact ctttcctaaa tagtagttta ctaaaatgct gaggggtaag     5100

ttagttagca agcactgact tgttcgtctc tctgctgcct tggaaaagaa acgatagaaa     5160

cgaaaagaat gtgttctgac tcgttcaact ctccgcggag gcacggaacg gtccgaacaa     5220

aggaggaaag cgtacgtttc ggagatatat ccgattagga aatggtggct ggctggcttc     5280

ctgcagctgg tggtcagtag gagttagtag tttggcatgt gaatgtgaga gtgtctatgg     5340

ggttgtttaa gttgcaagga agcaaaagcg ctcaattacg tgatgtttcg tggcacgggc     5400

cctctaacta aataggcctg tgcaggaagg caacctgatg gatccggtgg tggtggtggt     5460

agtggatcgt gtggaattat attattttat tttagtattt acttggcctt ggttatgatc     5520

ctttcgttgc acgtcatcat gctaggttcg gggttttagt tcagcccatg ggcaggaact     5580

aaaccaccgc tgcaggttat catccctggt gttactgcta ctaccaccac cacccccact     5640

catgtccttt ccaacccgat ctcgattact tacagcgtcg ctgaccgata cgctgctagc     5700

ccagtcacag gcattccgtt gagtatccca tccggaaagg aactcggcat gacttctggc     5760

atcagttgct cgaagccgta cccctcgatc atgccatcca tgagcggtgg catgaacggt     5820

gcttgcccca tgctcatctt acgactgtcg ccgtaggatg ataacggaga ccccttgaca     5880

gtggatgatg ggtcattgca ttccgcactg ccacatcgcc gcttgaactc gg             5932


<210>  14
<211>  1482
<212>  DNA
<213>  Aspergillus niger


<220>
<221>  misc_feature
<223>  AmyC cDNA

<400>  14
atgacaatct ttctgtttct ggccattttc gtggctacag ctctggcagc cacgcctgca       60

gaatggcgct cccagtcgat atatttcctg ctcaccgatc gctttgcgcg aacggataat      120

tctaccactg cttcttgtga cttgagcgct cggcaatatt gcggtggatc ctggcagggc      180

atcatcaatc agctggacta tattcaagga atgggcttta cagcgatctg gatcacaccc      240

gtaactgcac agatccccca agatactggt tacggacagg catatcacgg atactggcag      300

caggacgctt atgccctgaa ctcccattat ggtacggcag acgatctcaa agctctggct      360

tcagctcttc actcacgggg catgtatctc atggtggacg ttgttgccaa tcacatgggc      420

cacaatggta cggggagctc tgtggactac agtgtttata ggccatttaa ttcgcaaaag      480

tactttcaca acctctgttg gatctctgat tacaataacc agacaaacgt tgaagactgc      540

tggctaggcg ataacaccgt tgccttgccg gatcttgata ctaccagtac ggaggtgaag      600

aatatgtggt atgactgggt cgagtctctc gtctctaact actccgtcga cggcctccgc      660

gtagacacag tcaagaacgt acagaagaac ttctggcccg gctacaacaa tgcttcaggc      720

gtgtactgta ttggagaagt cttcgatggg gacgcctcat acacctgtcc ttatcaggaa      780

gacttggacg gagtccttaa ttaccccatg tactatccac tcctccgggc tttcgaatcc      840

accaacggca gtatcagcga cctctataac atgatcaaca ccgtgaaatc cacctgcaga      900

gattctacgc ttctagggac cttcgtcgaa aaccacgata acccacgctt tgccaactac      960

acaagcgaca tgtccctagc caaaaatgcc gcaacattca ctatcctggc tgacggcatt     1020

cccatcatat acgccggtca ggaacagcac tatagcggcg gtaatgaccc ctacaaccgc     1080

gaagcgacct ggctttcagg ctacaagacc accagcgagc tctacaccca tatcgccgca     1140

tcgaacaaga ttcgcaccca cgctataaaa caggataccg gatatctcac ctacaaaaac     1200

taccccatct accaagacac ctcgaccctt gccatgcgca aaggctacaa tggcacccaa     1260

actatcacgg tcctttctaa ccttggcgcc tcggggtcct catacacact ctccctccca     1320

ggaacaggct acacagccgg ccaaaagatt actgaaatct atacctgcac gaatctaaca     1380

gtcaactcaa atggctcggt gccagtaccc atgaagagcg ggttaccgcg gatcctctat     1440

cctgcagata agttggttaa tggaagctca ttttgcagtt ag                        1482


<210>  15
<211>  493
<212>  PRT
<213>  Aspergillus niger


<220>
<221>  misc_feature
<223>  AmyC protein

<400>  15

Met Thr Ile Phe Leu Phe Leu Ala Ile Phe Val Ala Thr Ala Leu Ala 
1               5                   10                  15      


Ala Thr Pro Ala Glu Trp Arg Ser Gln Ser Ile Tyr Phe Leu Leu Thr 
            20                  25                  30          


Asp Arg Phe Ala Arg Thr Asp Asn Ser Thr Thr Ala Ser Cys Asp Leu 
        35                  40                  45              


Ser Ala Arg Gln Tyr Cys Gly Gly Ser Trp Gln Gly Ile Ile Asn Gln 
    50                  55                  60                  


Leu Asp Tyr Ile Gln Gly Met Gly Phe Thr Ala Ile Trp Ile Thr Pro 
65                  70                  75                  80  


Val Thr Ala Gln Ile Pro Gln Asp Thr Gly Tyr Gly Gln Ala Tyr His 
                85                  90                  95      


Gly Tyr Trp Gln Gln Asp Ala Tyr Ala Leu Asn Ser His Tyr Gly Thr 
            100                 105                 110         


Ala Asp Asp Leu Lys Ala Leu Ala Ser Ala Leu His Ser Arg Gly Met 
        115                 120                 125             


Tyr Leu Met Val Asp Val Val Ala Asn His Met Gly His Asn Gly Thr 
    130                 135                 140                 


Gly Ser Ser Val Asp Tyr Ser Val Tyr Arg Pro Phe Asn Ser Gln Lys 
145                 150                 155                 160 


Tyr Phe His Asn Leu Cys Trp Ile Ser Asp Tyr Asn Asn Gln Thr Asn 
                165                 170                 175     


Val Glu Asp Cys Trp Leu Gly Asp Asn Thr Val Ala Leu Pro Asp Leu 
            180                 185                 190         


Asp Thr Thr Ser Thr Glu Val Lys Asn Met Trp Tyr Asp Trp Val Glu 
        195                 200                 205             


Ser Leu Val Ser Asn Tyr Ser Val Asp Gly Leu Arg Val Asp Thr Val 
    210                 215                 220                 


Lys Asn Val Gln Lys Asn Phe Trp Pro Gly Tyr Asn Asn Ala Ser Gly 
225                 230                 235                 240 


Val Tyr Cys Ile Gly Glu Val Phe Asp Gly Asp Ala Ser Tyr Thr Cys 
                245                 250                 255     


Pro Tyr Gln Glu Asp Leu Asp Gly Val Leu Asn Tyr Pro Met Tyr Tyr 
            260                 265                 270         


Pro Leu Leu Arg Ala Phe Glu Ser Thr Asn Gly Ser Ile Ser Asp Leu 
        275                 280                 285             


Tyr Asn Met Ile Asn Thr Val Lys Ser Thr Cys Arg Asp Ser Thr Leu 
    290                 295                 300                 


Leu Gly Thr Phe Val Glu Asn His Asp Asn Pro Arg Phe Ala Asn Tyr 
305                 310                 315                 320 


Thr Ser Asp Met Ser Leu Ala Lys Asn Ala Ala Thr Phe Thr Ile Leu 
                325                 330                 335     


Ala Asp Gly Ile Pro Ile Ile Tyr Ala Gly Gln Glu Gln His Tyr Ser 
            340                 345                 350         


Gly Gly Asn Asp Pro Tyr Asn Arg Glu Ala Thr Trp Leu Ser Gly Tyr 
        355                 360                 365             


Lys Thr Thr Ser Glu Leu Tyr Thr His Ile Ala Ala Ser Asn Lys Ile 
    370                 375                 380                 


Arg Thr His Ala Ile Lys Gln Asp Thr Gly Tyr Leu Thr Tyr Lys Asn 
385                 390                 395                 400 


Tyr Pro Ile Tyr Gln Asp Thr Ser Thr Leu Ala Met Arg Lys Gly Tyr 
                405                 410                 415     


Asn Gly Thr Gln Thr Ile Thr Val Leu Ser Asn Leu Gly Ala Ser Gly 
            420                 425                 430         


Ser Ser Tyr Thr Leu Ser Leu Pro Gly Thr Gly Tyr Thr Ala Gly Gln 
        435                 440                 445             


Lys Ile Thr Glu Ile Tyr Thr Cys Thr Asn Leu Thr Val Asn Ser Asn 
    450                 455                 460                 


Gly Ser Val Pro Val Pro Met Lys Ser Gly Leu Pro Arg Ile Leu Tyr 
465                 470                 475                 480 


Pro Ala Asp Lys Leu Val Asn Gly Ser Ser Phe Cys Ser 
                485                 490             


<210>  16
<211>  477
<212>  PRT
<213>  Aspergillus niger


<220>
<221>  misc_feature
<223>  AmyC mature protein

<400>  16

Ala Thr Pro Ala Glu Trp Arg Ser Gln Ser Ile Tyr Phe Leu Leu Thr 
1               5                   10                  15      


Asp Arg Phe Ala Arg Thr Asp Asn Ser Thr Thr Ala Ser Cys Asp Leu 
            20                  25                  30          


Ser Ala Arg Gln Tyr Cys Gly Gly Ser Trp Gln Gly Ile Ile Asn Gln 
        35                  40                  45              


Leu Asp Tyr Ile Gln Gly Met Gly Phe Thr Ala Ile Trp Ile Thr Pro 
    50                  55                  60                  


Val Thr Ala Gln Ile Pro Gln Asp Thr Gly Tyr Gly Gln Ala Tyr His 
65                  70                  75                  80  


Gly Tyr Trp Gln Gln Asp Ala Tyr Ala Leu Asn Ser His Tyr Gly Thr 
                85                  90                  95      


Ala Asp Asp Leu Lys Ala Leu Ala Ser Ala Leu His Ser Arg Gly Met 
            100                 105                 110         


Tyr Leu Met Val Asp Val Val Ala Asn His Met Gly His Asn Gly Thr 
        115                 120                 125             


Gly Ser Ser Val Asp Tyr Ser Val Tyr Arg Pro Phe Asn Ser Gln Lys 
    130                 135                 140                 


Tyr Phe His Asn Leu Cys Trp Ile Ser Asp Tyr Asn Asn Gln Thr Asn 
145                 150                 155                 160 


Val Glu Asp Cys Trp Leu Gly Asp Asn Thr Val Ala Leu Pro Asp Leu 
                165                 170                 175     


Asp Thr Thr Ser Thr Glu Val Lys Asn Met Trp Tyr Asp Trp Val Glu 
            180                 185                 190         


Ser Leu Val Ser Asn Tyr Ser Val Asp Gly Leu Arg Val Asp Thr Val 
        195                 200                 205             


Lys Asn Val Gln Lys Asn Phe Trp Pro Gly Tyr Asn Asn Ala Ser Gly 
    210                 215                 220                 


Val Tyr Cys Ile Gly Glu Val Phe Asp Gly Asp Ala Ser Tyr Thr Cys 
225                 230                 235                 240 


Pro Tyr Gln Glu Asp Leu Asp Gly Val Leu Asn Tyr Pro Met Tyr Tyr 
                245                 250                 255     


Pro Leu Leu Arg Ala Phe Glu Ser Thr Asn Gly Ser Ile Ser Asp Leu 
            260                 265                 270         


Tyr Asn Met Ile Asn Thr Val Lys Ser Thr Cys Arg Asp Ser Thr Leu 
        275                 280                 285             


Leu Gly Thr Phe Val Glu Asn His Asp Asn Pro Arg Phe Ala Asn Tyr 
    290                 295                 300                 


Thr Ser Asp Met Ser Leu Ala Lys Asn Ala Ala Thr Phe Thr Ile Leu 
305                 310                 315                 320 


Ala Asp Gly Ile Pro Ile Ile Tyr Ala Gly Gln Glu Gln His Tyr Ser 
                325                 330                 335     


Gly Gly Asn Asp Pro Tyr Asn Arg Glu Ala Thr Trp Leu Ser Gly Tyr 
            340                 345                 350         


Lys Thr Thr Ser Glu Leu Tyr Thr His Ile Ala Ala Ser Asn Lys Ile 
        355                 360                 365             


Arg Thr His Ala Ile Lys Gln Asp Thr Gly Tyr Leu Thr Tyr Lys Asn 
    370                 375                 380                 


Tyr Pro Ile Tyr Gln Asp Thr Ser Thr Leu Ala Met Arg Lys Gly Tyr 
385                 390                 395                 400 


Asn Gly Thr Gln Thr Ile Thr Val Leu Ser Asn Leu Gly Ala Ser Gly 
                405                 410                 415     


Ser Ser Tyr Thr Leu Ser Leu Pro Gly Thr Gly Tyr Thr Ala Gly Gln 
            420                 425                 430         


Lys Ile Thr Glu Ile Tyr Thr Cys Thr Asn Leu Thr Val Asn Ser Asn 
        435                 440                 445             


Gly Ser Val Pro Val Pro Met Lys Ser Gly Leu Pro Arg Ile Leu Tyr 
    450                 455                 460                 


Pro Ala Asp Lys Leu Val Asn Gly Ser Ser Phe Cys Ser 
465                 470                 475         



<210>  17
<211>  1575
<212>  DNA
<213>  Aspergillus niger


<220>
<221>  misc_feature
<223>  AmyC cDNA

<400>  17
atgacaatct ttctgtttct ggccattttc gtggctacag ctctggcagc cacgcctgca       60

gaatggcgct cccagtcgat atatttcctg ctcaccgatc gctttgcgcg aacggataat      120

tctaccactg cttcttgtga cttgagcgct cggcaatatt gcggtggatc ctggcagggc      180

atcatcaatc agctggacta tattcaagga atgggcttta cagcgatctg gatcacaccc      240

gtaactgcac agatccccca agatactggt tacggacagg catatcacgg atactggcag      300

caggacgctt atgccctgaa ctcccattat ggtacggcag acgatctcaa agctctggct      360

tcagctcttc actcacgggg catgtatctc atggtggacg ttgttgccaa tcacatgggc      420

cacaatggta cggggagctc tgtggactac agtgtttata ggccatttaa ttcgcaaaag      480

tactttcaca acctctgttg gatctctgat tacaataacc agacaaacgt tgaagactgc      540

tggctaggcg ataacaccgt tgccttgccg gatcttgata ctaccagtac ggaggtgaag      600

aatatgtggt atgactgggt cgagtctctc gtctctaact actccgtcga cggcctccgc      660

gtagacacag tcaagaacgt acagaagaac ttctggcccg gctacaacaa tgcttcaggc      720

gtgtactgta ttggagaagt cttcgatggg gacgcctcat acacctgtcc ttatcaggaa      780

gacttggacg gagtccttaa ttaccccatg tactatccac tcctccgggc tttcgaatcc      840

accaacggca gtatcagcga cctctataac atgatcaaca ccgtgaaatc cacctgcaga      900

gattctacgc ttctagggac cttcgtcgaa aaccacgata acccacgctt tgccaactac      960

acaagcgaca tgtccctagc caaaaatgcc gcaacattca ctatcctggc tgacggcatt     1020

cccatcatat acgccggtca ggaacagcac tatagcggcg gtaatgaccc ctacaaccgc     1080

gaagcgacct ggctttcagg ctacaagacc accagcgagc tctacaccca tatcgccgca     1140

tcgaacaaga ttcgcaccca cgctataaaa caggataccg gatatctcac ctacaaaaac     1200

taccccatct accaagacac ctcgaccctt gccatgcgca aaggctacaa tggcacccaa     1260

actatcacgg tcctttctaa ccttggcgcc tcggggtcct catacacact ctccctccca     1320

ggaacaggct acacagccgg ccaaaagatt actgaaatct atacctgcac gaatctaaca     1380

gtcaactcaa atggctcggt gccagtaccc atgaagagcg ggttaccgcg gatcctctat     1440

cctgcagata agttggttaa tggaagctca ttttgcagct ctgcgatcac tgttttcaag     1500

gatgcaggag gaggcgtgtt gttctttagc tacactgtaa ttttcgctca ggtgcttatt     1560

gctataatga cgtga                                                      1575


<210>  18
<211>  524
<212>  PRT
<213>  Aspergillus niger


<220>
<221>  misc_feature
<223>  AmyC protein

<400>  18

Met Thr Ile Phe Leu Phe Leu Ala Ile Phe Val Ala Thr Ala Leu Ala 
1               5                   10                  15      


Ala Thr Pro Ala Glu Trp Arg Ser Gln Ser Ile Tyr Phe Leu Leu Thr 
            20                  25                  30          


Asp Arg Phe Ala Arg Thr Asp Asn Ser Thr Thr Ala Ser Cys Asp Leu 
        35                  40                  45              


Ser Ala Arg Gln Tyr Cys Gly Gly Ser Trp Gln Gly Ile Ile Asn Gln 
    50                  55                  60                  


Leu Asp Tyr Ile Gln Gly Met Gly Phe Thr Ala Ile Trp Ile Thr Pro 
65                  70                  75                  80  


Val Thr Ala Gln Ile Pro Gln Asp Thr Gly Tyr Gly Gln Ala Tyr His 
                85                  90                  95      


Gly Tyr Trp Gln Gln Asp Ala Tyr Ala Leu Asn Ser His Tyr Gly Thr 
            100                 105                 110         


Ala Asp Asp Leu Lys Ala Leu Ala Ser Ala Leu His Ser Arg Gly Met 
        115                 120                 125             


Tyr Leu Met Val Asp Val Val Ala Asn His Met Gly His Asn Gly Thr 
    130                 135                 140                 


Gly Ser Ser Val Asp Tyr Ser Val Tyr Arg Pro Phe Asn Ser Gln Lys 
145                 150                 155                 160 


Tyr Phe His Asn Leu Cys Trp Ile Ser Asp Tyr Asn Asn Gln Thr Asn 
                165                 170                 175     


Val Glu Asp Cys Trp Leu Gly Asp Asn Thr Val Ala Leu Pro Asp Leu 
            180                 185                 190         


Asp Thr Thr Ser Thr Glu Val Lys Asn Met Trp Tyr Asp Trp Val Glu 
        195                 200                 205             


Ser Leu Val Ser Asn Tyr Ser Val Asp Gly Leu Arg Val Asp Thr Val 
    210                 215                 220                 


Lys Asn Val Gln Lys Asn Phe Trp Pro Gly Tyr Asn Asn Ala Ser Gly 
225                 230                 235                 240 


Val Tyr Cys Ile Gly Glu Val Phe Asp Gly Asp Ala Ser Tyr Thr Cys 
                245                 250                 255     


Pro Tyr Gln Glu Asp Leu Asp Gly Val Leu Asn Tyr Pro Met Tyr Tyr 
            260                 265                 270         


Pro Leu Leu Arg Ala Phe Glu Ser Thr Asn Gly Ser Ile Ser Asp Leu 
        275                 280                 285             


Tyr Asn Met Ile Asn Thr Val Lys Ser Thr Cys Arg Asp Ser Thr Leu 
    290                 295                 300                 


Leu Gly Thr Phe Val Glu Asn His Asp Asn Pro Arg Phe Ala Asn Tyr 
305                 310                 315                 320 


Thr Ser Asp Met Ser Leu Ala Lys Asn Ala Ala Thr Phe Thr Ile Leu 
                325                 330                 335     


Ala Asp Gly Ile Pro Ile Ile Tyr Ala Gly Gln Glu Gln His Tyr Ser 
            340                 345                 350         


Gly Gly Asn Asp Pro Tyr Asn Arg Glu Ala Thr Trp Leu Ser Gly Tyr 
        355                 360                 365             


Lys Thr Thr Ser Glu Leu Tyr Thr His Ile Ala Ala Ser Asn Lys Ile 
    370                 375                 380                 


Arg Thr His Ala Ile Lys Gln Asp Thr Gly Tyr Leu Thr Tyr Lys Asn 
385                 390                 395                 400 


Tyr Pro Ile Tyr Gln Asp Thr Ser Thr Leu Ala Met Arg Lys Gly Tyr 
                405                 410                 415     


Asn Gly Thr Gln Thr Ile Thr Val Leu Ser Asn Leu Gly Ala Ser Gly 
            420                 425                 430         


Ser Ser Tyr Thr Leu Ser Leu Pro Gly Thr Gly Tyr Thr Ala Gly Gln 
        435                 440                 445             


Lys Ile Thr Glu Ile Tyr Thr Cys Thr Asn Leu Thr Val Asn Ser Asn 
    450                 455                 460                 


Gly Ser Val Pro Val Pro Met Lys Ser Gly Leu Pro Arg Ile Leu Tyr 
465                 470                 475                 480 


Pro Ala Asp Lys Leu Val Asn Gly Ser Ser Phe Cys Ser Ser Ala Ile 
                485                 490                 495     


Thr Val Phe Lys Asp Ala Gly Gly Gly Val Leu Phe Phe Ser Tyr Thr 
            500                 505                 510         


Val Ile Phe Ala Gln Val Leu Ile Ala Ile Met Thr 
        515                 520                 


<210>  19
<211>  508
<212>  PRT
<213>  Aspergillus niger


<220>
<221>  misc_feature
<223>  AmyC mature protein

<400>  19

Ala Thr Pro Ala Glu Trp Arg Ser Gln Ser Ile Tyr Phe Leu Leu Thr 
1               5                   10                  15      


Asp Arg Phe Ala Arg Thr Asp Asn Ser Thr Thr Ala Ser Cys Asp Leu 
            20                  25                  30          


Ser Ala Arg Gln Tyr Cys Gly Gly Ser Trp Gln Gly Ile Ile Asn Gln 
        35                  40                  45              


Leu Asp Tyr Ile Gln Gly Met Gly Phe Thr Ala Ile Trp Ile Thr Pro 
    50                  55                  60                  


Val Thr Ala Gln Ile Pro Gln Asp Thr Gly Tyr Gly Gln Ala Tyr His 
65                  70                  75                  80  


Gly Tyr Trp Gln Gln Asp Ala Tyr Ala Leu Asn Ser His Tyr Gly Thr 
                85                  90                  95      


Ala Asp Asp Leu Lys Ala Leu Ala Ser Ala Leu His Ser Arg Gly Met 
            100                 105                 110         


Tyr Leu Met Val Asp Val Val Ala Asn His Met Gly His Asn Gly Thr 
        115                 120                 125             


Gly Ser Ser Val Asp Tyr Ser Val Tyr Arg Pro Phe Asn Ser Gln Lys 
    130                 135                 140                 


Tyr Phe His Asn Leu Cys Trp Ile Ser Asp Tyr Asn Asn Gln Thr Asn 
145                 150                 155                 160 


Val Glu Asp Cys Trp Leu Gly Asp Asn Thr Val Ala Leu Pro Asp Leu 
                165                 170                 175     


Asp Thr Thr Ser Thr Glu Val Lys Asn Met Trp Tyr Asp Trp Val Glu 
            180                 185                 190         


Ser Leu Val Ser Asn Tyr Ser Val Asp Gly Leu Arg Val Asp Thr Val 
        195                 200                 205             


Lys Asn Val Gln Lys Asn Phe Trp Pro Gly Tyr Asn Asn Ala Ser Gly 
    210                 215                 220                 


Val Tyr Cys Ile Gly Glu Val Phe Asp Gly Asp Ala Ser Tyr Thr Cys 
225                 230                 235                 240 


Pro Tyr Gln Glu Asp Leu Asp Gly Val Leu Asn Tyr Pro Met Tyr Tyr 
                245                 250                 255     


Pro Leu Leu Arg Ala Phe Glu Ser Thr Asn Gly Ser Ile Ser Asp Leu 
            260                 265                 270         


Tyr Asn Met Ile Asn Thr Val Lys Ser Thr Cys Arg Asp Ser Thr Leu 
        275                 280                 285             


Leu Gly Thr Phe Val Glu Asn His Asp Asn Pro Arg Phe Ala Asn Tyr 
    290                 295                 300                 


Thr Ser Asp Met Ser Leu Ala Lys Asn Ala Ala Thr Phe Thr Ile Leu 
305                 310                 315                 320 


Ala Asp Gly Ile Pro Ile Ile Tyr Ala Gly Gln Glu Gln His Tyr Ser 
                325                 330                 335     


Gly Gly Asn Asp Pro Tyr Asn Arg Glu Ala Thr Trp Leu Ser Gly Tyr 
            340                 345                 350         


Lys Thr Thr Ser Glu Leu Tyr Thr His Ile Ala Ala Ser Asn Lys Ile 
        355                 360                 365             


Arg Thr His Ala Ile Lys Gln Asp Thr Gly Tyr Leu Thr Tyr Lys Asn 
    370                 375                 380                 


Tyr Pro Ile Tyr Gln Asp Thr Ser Thr Leu Ala Met Arg Lys Gly Tyr 
385                 390                 395                 400 


Asn Gly Thr Gln Thr Ile Thr Val Leu Ser Asn Leu Gly Ala Ser Gly 
                405                 410                 415     


Ser Ser Tyr Thr Leu Ser Leu Pro Gly Thr Gly Tyr Thr Ala Gly Gln 
            420                 425                 430         


Lys Ile Thr Glu Ile Tyr Thr Cys Thr Asn Leu Thr Val Asn Ser Asn 
        435                 440                 445             


Gly Ser Val Pro Val Pro Met Lys Ser Gly Leu Pro Arg Ile Leu Tyr 
    450                 455                 460                 


Pro Ala Asp Lys Leu Val Asn Gly Ser Ser Phe Cys Ser Ser Ala Ile 
465                 470                 475                 480 


Thr Val Phe Lys Asp Ala Gly Gly Gly Val Leu Phe Phe Ser Tyr Thr 
                485                 490                 495     


Val Ile Phe Ala Gln Val Leu Ile Ala Ile Met Thr 
            500                 505           

<210>  20
<211>  653
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GLA-proPLA2 fusion protein

<400>  20

Met Ser Phe Arg Ser Leu Leu Ala Leu Ser Gly Leu Val Cys Thr Gly 
1               5                   10                  15      


Leu Ala Asn Val Ile Ser Lys Arg Ala Thr Leu Asp Ser Trp Leu Ser 
            20                  25                  30          


Asn Glu Ala Thr Val Ala Arg Thr Ala Ile Leu Asn Asn Ile Gly Ala 
        35                  40                  45              


Asp Gly Ala Trp Val Ser Gly Ala Asp Ser Gly Ile Val Val Ala Ser 
    50                  55                  60                  


Pro Ser Thr Asp Asn Pro Asp Tyr Phe Tyr Thr Trp Thr Arg Asp Ser 
65                  70                  75                  80  


Gly Leu Val Leu Lys Thr Leu Val Asp Leu Phe Arg Asn Gly Asp Thr 
                85                  90                  95      


Ser Leu Leu Ser Thr Ile Glu Asn Tyr Ile Ser Ala Gln Ala Ile Val 
            100                 105                 110         


Gln Gly Ile Ser Asn Pro Ser Gly Asp Leu Ser Ser Gly Ala Gly Leu 
        115                 120                 125             


Gly Glu Pro Lys Phe Asn Val Asp Glu Thr Ala Tyr Thr Gly Ser Trp 
    130                 135                 140                 


Gly Arg Pro Gln Arg Asp Gly Pro Ala Leu Arg Ala Thr Ala Met Ile 
145                 150                 155                 160 


Gly Phe Gly Gln Trp Leu Leu Asp Asn Gly Tyr Thr Ser Thr Ala Thr 
                165                 170                 175     


Asp Ile Val Trp Pro Leu Val Arg Asn Asp Leu Ser Tyr Val Ala Gln 
            180                 185                 190         


Tyr Trp Asn Gln Thr Gly Tyr Asp Leu Trp Glu Glu Val Asn Gly Ser 
        195                 200                 205             


Ser Phe Phe Thr Ile Ala Val Gln His Arg Ala Leu Val Glu Gly Ser 
    210                 215                 220                 


Ala Phe Ala Thr Ala Val Gly Ser Ser Cys Ser Trp Cys Asp Ser Gln 
225                 230                 235                 240 


Ala Pro Glu Ile Leu Cys Tyr Leu Gln Ser Phe Trp Thr Gly Ser Phe 
                245                 250                 255     


Ile Leu Ala Asn Phe Asp Ser Ser Arg Ser Gly Lys Asp Ala Asn Thr 
            260                 265                 270         


Leu Leu Gly Ser Ile His Thr Phe Asp Pro Glu Ala Ala Cys Asp Asp 
        275                 280                 285             


Ser Thr Phe Gln Pro Cys Ser Pro Arg Ala Leu Ala Asn His Lys Glu 
    290                 295                 300                 


Val Val Asp Ser Phe Arg Ser Ile Tyr Thr Leu Asn Asp Gly Leu Ser 
305                 310                 315                 320 


Asp Ser Glu Ala Val Ala Val Gly Arg Tyr Pro Glu Asp Thr Tyr Tyr 
                325                 330                 335     


Asn Gly Asn Pro Trp Phe Leu Cys Thr Leu Ala Ala Ala Glu Gln Leu 
            340                 345                 350         


Tyr Asp Ala Leu Tyr Gln Trp Asp Lys Gln Gly Ser Leu Glu Val Thr 
        355                 360                 365             


Asp Val Ser Leu Asp Phe Phe Lys Ala Leu Tyr Ser Asp Ala Ala Thr 
    370                 375                 380                 


Gly Thr Tyr Ser Ser Ser Ser Ser Thr Tyr Ser Ser Ile Val Asp Ala 
385                 390                 395                 400 


Val Lys Thr Phe Ala Asp Gly Phe Val Ser Ile Val Glu Thr His Ala 
                405                 410                 415     


Ala Ser Asn Gly Ser Met Ser Glu Gln Tyr Asp Lys Ser Asp Gly Glu 
            420                 425                 430         


Gln Leu Ser Ala Arg Asp Leu Thr Trp Ser Tyr Ala Ala Leu Leu Thr 
        435                 440                 445             


Ala Asn Asn Arg Arg Asn Ser Val Val Pro Ala Ser Trp Gly Glu Thr 
    450                 455                 460                 


Ser Ala Ser Ser Val Pro Gly Thr Cys Ala Ala Thr Ser Ala Ile Gly 
465                 470                 475                 480 


Thr Tyr Ser Ser Val Thr Val Thr Ser Trp Pro Ser Ile Val Ala Thr 
                485                 490                 495     


Gly Gly Thr Thr Thr Thr Ala Thr Pro Thr Gly Ser Gly Ser Val Thr 
            500                 505                 510         


Ser Thr Ser Lys Thr Thr Ala Thr Ala Ser Gln Glu Gly Ile Ser Ser 
        515                 520                 525             


Arg Ala Leu Trp Gln Phe Arg Ser Met Ile Lys Cys Ala Ile Pro Gly 
    530                 535                 540                 


Ser His Pro Leu Met Asp Phe Asn Asn Tyr Gly Cys Tyr Cys Gly Leu 
545                 550                 555                 560 


Gly Gly Ser Gly Thr Pro Val Asp Glu Leu Asp Arg Cys Cys Glu Thr 
                565                 570                 575     


His Asp Asn Cys Tyr Arg Asp Ala Lys Asn Leu Asp Ser Cys Lys Phe 
            580                 585                 590         


Leu Val Asp Asn Pro Tyr Thr Glu Ser Tyr Ser Tyr Ser Cys Ser Asn 
        595                 600                 605             


Thr Glu Ile Thr Cys Asn Ser Lys Asn Asn Ala Cys Glu Ala Phe Ile 
    610                 615                 620                 


Cys Asn Cys Asp Arg Asn Ala Ala Ile Cys Phe Ser Lys Ala Pro Tyr 
625                 630                 635                 640 


Asn Lys Glu His Lys Asn Leu Asp Thr Lys Lys Tyr Cys 
                645                 650             


  