               SEQUENCE LISTING

<110> Arla Foods amba
      Forsyth Dental Infirmary for Children (d/b/a The Forsyth Institute)

<120> PHARMACEUTICALLY ACTIVE MOLECULES FOR USE IN SUPPRESSION OR PREVENTION OF TUMOR GROWTH AND COMPOSITIONS CONTAINING SUCH MOLECULES

<130> P1356PC00

<160> 22

<170> BiSSAP 1.2

<210> 1
<211> 278
<212> PRT
<213> Bos taurus


<220> 
<221> MOTIF
<222> 152..154
<223> RGD

<400> 1
Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Ala Ser Ala 
1               5                   10                  15      
Leu Pro Val Lys Pro Thr Ser Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          
Asn Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Lys Pro Asp Pro 
        35                  40                  45              
Ser Gln Lys Gln Thr Phe Leu Ala Pro Gln Asn Ser Val Ser Ser Glu 
    50                  55                  60                  
Glu Thr Asp Asp Asn Lys Gln Asn Thr Leu Pro Ser Lys Ser Asn Glu 
65                  70                  75                  80  
Ser Pro Glu Gln Thr Asp Asp Leu Asp Asp Asp Asp Asp Asn Ser Gln 
                85                  90                  95      
Asp Val Asn Ser Asn Asp Ser Asp Asp Ala Glu Thr Thr Asp Asp Pro 
            100                 105                 110         
Asp His Ser Asp Glu Ser His His Ser Asp Glu Ser Asp Glu Val Asp 
        115                 120                 125             
Phe Pro Thr Asp Ile Pro Thr Ile Ala Val Phe Thr Pro Phe Ile Pro 
    130                 135                 140                 
Thr Glu Ser Ala Asn Asp Gly Arg Gly Asp Ser Val Ala Tyr Gly Leu 
145                 150                 155                 160 
Lys Ser Arg Ser Lys Lys Phe Arg Arg Ser Asn Val Gln Ser Pro Asp 
                165                 170                 175     
Ala Thr Glu Glu Asp Phe Thr Ser His Ile Glu Ser Glu Glu Met His 
            180                 185                 190         
Asp Ala Pro Lys Lys Thr Ser Gln Leu Thr Asp His Ser Lys Glu Thr 
        195                 200                 205             
Asn Ser Ser Glu Leu Ser Lys Glu Leu Thr Pro Lys Ala Lys Asp Lys 
    210                 215                 220                 
Asn Lys His Ser Asn Leu Ile Glu Ser Gln Glu Asn Ser Lys Leu Ser 
225                 230                 235                 240 
Gln Glu Phe His Ser Leu Glu Asp Lys Leu Asp Leu Asp His Lys Ser 
                245                 250                 255     
Glu Glu Asp Lys His Leu Lys Ile Arg Ile Ser His Glu Leu Asp Ser 
            260                 265                 270         
Ala Ser Ser Glu Val Asn 
        275             

<210> 2
<211> 314
<212> PRT
<213> Homo sapiens

<220> 
<223> Human OPN

<400> 2
Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      
Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          
Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              
Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
    50                  55                  60                  
Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
65                  70                  75                  80  
Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His 
                85                  90                  95      
Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp 
            100                 105                 110         
Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu 
        115                 120                 125             
Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu 
    130                 135                 140                 
Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly 
145                 150                 155                 160 
Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg 
                165                 170                 175     
Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His 
            180                 185                 190         
Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala 
        195                 200                 205             
Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser 
    210                 215                 220                 
Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His Ser His 
225                 230                 235                 240 
Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu 
                245                 250                 255     
His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser Arg Glu 
            260                 265                 270         
Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val Val Asp 
        275                 280                 285             
Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile Ser His 
    290                 295                 300                 
Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
305                 310                 

<210> 3
<211> 7
<212> PRT
<213> Bos taurus


<400> 3
Ser Val Ala Tyr Gly Leu Lys 
1               5           

<210> 4
<211> 7
<212> PRT
<213> Homo sapiens


<400> 4
Ser Val Val Tyr Gly Leu Arg 
1               5           

<210> 5
<211> 7
<212> PRT
<213> Mus musculus


<400> 5
Ser Leu Ala Tyr Gly Leu Arg 
1               5           

<210> 6
<211> 7
<212> PRT
<213> Oryctolagus


<400> 6
Ser Val Ala Tyr Arg Leu Arg 
1               5           

<210> 7
<211> 5
<212> PRT
<213> Bos taurus


<400> 7
Gly Asp Ser Val Ala 
1               5   

<210> 8
<211> 5
<212> PRT
<213> Homo sapiens


<400> 8
Gly Asp Ser Val Val 
1               5   

<210> 9
<211> 5
<212> PRT
<213> Mus musculus


<400> 9
Gly Asp Ser Leu Ala 
1               5   

<210> 10
<211> 5
<212> PRT
<213> artificial sequences

<220> 
<223> artificial penta peptide

<400> 10
Gly Asp Ser Leu Val 
1               5   

<210> 11
<211> 16
<212> PRT
<213> Bos taurus

<220> 
<223> Fragment from bovine OPN

<400> 11
Ile Pro Thr Glu Ser Ala Asn Asp Gly Arg Gly Asp Ser Val Ala Tyr 
1               5                   10                  15      



<210> 12
<211> 17
<212> PRT
<213> Bos taurus


<400> 12
Ile Pro Thr Glu Ser Ala Asn Asp Gly Arg Gly Asp Ser Val Ala Tyr 
1               5                   10                  15      
Gly 
    

<210> 13
<211> 18
<212> PRT
<213> Bos taurus


<400> 13
Ile Pro Thr Glu Ser Ala Asn Asp Gly Arg Gly Asp Ser Val Ala Tyr 
1               5                   10                  15      
Gly Leu 
        

<210> 14
<211> 19
<212> PRT
<213> Bos taurus


<400> 14
Ile Pro Thr Glu Ser Ala Asn Asp Gly Arg Gly Asp Ser Val Ala Tyr 
1               5                   10                  15      
Gly Leu Lys 
            

<210> 15
<211> 21
<212> PRT
<213> Bos taurus


<400> 15
Ile Pro Thr Glu Ser Ala Asn Asp Gly Arg Gly Asp Ser Val Ala Tyr 
1               5                   10                  15      
Gly Leu Lys Ser Arg 
            20      

<210> 16
<211> 9
<212> PRT
<213> Bos taurus


<400> 16
Gly Asp Ser Val Ala Tyr Gly Leu Lys 
1               5                   

<210> 17
<211> 11
<212> PRT
<213> Bos taurus


<400> 17
Gly Asp Ser Val Ala Tyr Gly Leu Lys Ser Arg 
1               5                   10      

<210> 18
<211> 9
<212> PRT
<213> Bos taurus


<400> 18
Gly Asp Ser Val Ala Tyr Gly Leu Lys 
1               5                   

<210> 19
<211> 25
<212> PRT
<213> Bos taurus


<400> 19
Ile Pro Thr Glu Ser Ala Asn Asp Gly Arg Gly Asp Ser Val Ala Tyr 
1               5                   10                  15      
Gly Leu Lys Ser Arg Ser Lys Lys Phe 
            20                  25  

<210> 20
<211> 6
<212> PRT
<213> Bos taurus

<220> 
<223> Fragment from bovine OPN

<400> 20
Gly Asp Ser Val Ala Tyr 
1               5       

<210> 21
<211> 5
<212> PRT
<213> Bos taurus


<400> 21
Val Ala Tyr Gly Leu 
1               5   

<210> 22
<211> 8
<212> PRT
<213> Bos taurus


<220> 
<221> VARIANT
<222> 1
<223> Ala

<220> 
<221> VARIANT
<222> 2
<223> Glu

<220> 
<221> VARIANT
<222> 4
<223> Asp or Ile or Leu or Gly

<220> 
<221> VARIANT
<222> 3
<223> Thr

<220> 
<221> VARIANT
<222> 5
<223> Val or Ile or Leu or Gly

<220> 
<221> VARIANT
<222> 7
<223> Ala

<220> 
<221> VARIANT
<222> 8
<223> Ala or Ile or Gly or Val

<400> 22
Gly Asp Ser Val Ala Tyr Gly Leu 
1               5               

