               SEQUENCE LISTING

<110> Glycotope GmbH

<120> Novel therapeutic treatments with anti-HER2 antibodies having a low fucosylation

<130> 54 662 K

<150> US 61/673,216
<151> 2012-07-18

<150> US 61/673,201
<151> 2012-07-18

<150> US 61/673,229
<151> 2012-07-18

<150> EP 12 197 768.0
<151> 2012-12-18

<160> 10

<170> BiSSAP 1.0

<210> 1
<211> 5
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..5
<223> /mol_type="protein"
      /note="CDR-H1"
      /organism="artificial sequences"

<400> 1
Asp Thr Tyr Ile His 
1               5

<210> 2
<211> 17
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..17
<223> /mol_type="protein"
      /note="CDR-H2"
      /organism="artificial sequences"

<400> 2
Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
1               5                   10                   15    
Gly 
    

<210> 3
<211> 11
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..11
<223> /mol_type="protein"
      /note="CDR-H3"
      /organism="artificial sequences"

<400> 3
Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
1               5                   10    

<210> 4
<211> 11
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..11
<223> /mol_type="protein"
      /note="CDR-L1"
      /organism="artificial sequences"

<400> 4
Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala 
1               5                   10    

<210> 5
<211> 7
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..7
<223> /mol_type="protein"
      /note="CDR-L2"
      /organism="artificial sequences"

<400> 5
Ser Ala Ser Phe Leu Tyr Ser 
1               5        

<210> 6
<211> 9
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..9
<223> /mol_type="protein"
      /note="CDR-L3"
      /organism="artificial sequences"

<400> 6
Gln Gln His Tyr Thr Thr Pro Pro Thr 
1               5                

<210> 7
<211> 119
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..119
<223> /mol_type="protein"
      /note="heavy chain variable region"
      /organism="artificial sequences"

<400> 7
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                   15    
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                   25                  30        
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                   40                  45            
Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                   55                  60                
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                   70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                   90                  95    
Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                  105                110        
Gly Thr Leu Val Thr Val Ser 
        115                

<210> 8
<211> 108
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..108
<223> /mol_type="protein"
      /note="light chain variable region"
      /organism="artificial sequences"

<400> 8
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                   15    
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                   25                  30        
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                   40                  45            
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                   55                  60                
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                   70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                   90                  95    
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                  105            

<210> 9
<211> 450
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..450
<223> /mol_type="protein"
      /note="heavy chain"
      /organism="artificial sequences"

<400> 9
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                   15    
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                   25                  30        
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                   40                  45            
Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                   55                  60                
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                   70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                   90                  95    
Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                  105                110        
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                  120                125            
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                  135                140                
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                  150                155                  160
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                  170                175    
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                  185                190        
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                  200                205            
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                  215                220                
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                  230                235                  240
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                  250                255    
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                  265                270        
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                  280                285            
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                  295                300                
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                  310                315                  320
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                  330                335    
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                  345                350        
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                  360                365            
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                  375                380                
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                  390                395                  400
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                  410                415    
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                  425                430        
Glu Gly Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                  440                445            
Gly Lys 
    450

<210> 10
<211> 214
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..214
<223> /mol_type="protein"
      /note="light chain"
      /organism="artificial sequences"

<400> 10
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                   15    
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                   25                  30        
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                   40                  45            
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                   55                  60                
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                   70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                   90                  95    
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                  105                110        
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                  120                125            
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                  135                140                
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                  150                155                  160
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                  170                175    
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                  185                190        
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                  200                205            
Phe Asn Arg Gly Glu Cys 
    210                

