                         SEQUENCE LISTING

<110>  Cincinnati Children's Hospital Medical Center
       Tan, Ming
       Jiang, Xi
       Wang, Leyi
 
<120>  PROTEIN COMPLEX SYSTEM FOR INCREASED IMMUNOGENICITY AND 
       FUNCTIONALITY, AND METHODS MAKING AND USE

<130>  CHM-047M

<150>  61670288
<151>  2012-07-11

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-HEV P fusion protein

<400>  1

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Asp Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Val Pro Arg 
    210                 215                 220                 


Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn 
225                 230                 235                 240 


Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr Asp Gln Thr Thr 
                245                 250                 255     


Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp Thr Val Thr Phe 
            260                 265                 270         


Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala Arg Ser Leu Asp Trp 
        275                 280                 285             


Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Thr Thr Ile Gln Gln Tyr 
    290                 295                 300                 


Ser Lys Thr Phe Tyr Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp 
305                 310                 315                 320 


Glu Ala Ser Thr Thr Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr 
                325                 330                 335     


Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly His Arg Val Ala 
            340                 345                 350         


Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ala Gly Pro Thr Ser Ile Ser 
        355                 360                 365             


Ala Val Gly Val Leu Ala Pro His Ser Ala Leu Ala Ala Leu Glu Asp 
    370                 375                 380                 


Thr Val Asp Tyr Pro Cys Asp Cys Arg Gly Asp Cys Phe Cys 
385                 390                 395             


<210>  2
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-NoV P+

<400>  2

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Asp Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Val Pro Arg 
    210                 215                 220                 


Ser Arg Thr Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met 
225                 230                 235                 240 


Ser Asn Ser Arg Phe Pro Ile Pro Leu Glu Lys Leu Tyr Thr Gly Pro 
                245                 250                 255     


Ser Ser Ala Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp 
            260                 265                 270         


Gly Val Leu Leu Gly Thr Thr Gln Leu Ser Ala Val Asn Ile Cys Thr 
        275                 280                 285             


Phe Arg Gly Asp Val Thr His Ile Ala Gly Ser His Asp Tyr Ile Met 
    290                 295                 300                 


Asn Leu Ala Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile 
305                 310                 315                 320 


Pro Ala Pro Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Met 
                325                 330                 335     


Leu Thr Gln Thr Thr Arg Glu Asp Gly Ser Thr Arg Ala His Lys Ala 
            340                 345                 350         


Thr Val Ser Thr Gly Ser Val His Phe Thr Pro Lys Leu Gly Ser Val 
        355                 360                 365             


Gln Tyr Thr Thr Asp Thr Asn Asn Asp Leu Gln Thr Gly Gln Asn Thr 
    370                 375                 380                 


Lys Phe Thr Pro Val Gly Val Ile Gln Asp Gly Asn Asn His Gln Asn 
385                 390                 395                 400 


Glu Pro Gln Gln Trp Val Leu Pro Asn Tyr Ser Gly Arg Thr Gly His 
                405                 410                 415     


Asn Val His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln 
            420                 425                 430         


Leu Leu Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn 
        435                 440                 445             


Met Asn Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr 
    450                 455                 460                 


Gln Glu Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val 
465                 470                 475                 480 


Asn Pro Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser 
                485                 490                 495     


Gly Tyr Val Thr Val Ala His Thr Gly Pro His Asp Leu Val Ile Pro 
            500                 505                 510         


Pro Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr 
        515                 520                 525             


Leu Ala Pro Met Gly Asn Gly Ala Gly Arg Arg Arg Ala Leu Cys Asp 
    530                 535                 540                 


Cys Arg Gly Asp Cys Phe Cys 
545                 550     


<210>  3
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-NoV P-

<400>  3

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Val Pro Arg 
    210                 215                 220                 


Ser Arg Thr Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met 
225                 230                 235                 240 


Ser Asn Ser Arg Phe Pro Ile Pro Leu Glu Lys Leu Tyr Thr Gly Pro 
                245                 250                 255     


Ser Ser Ala Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp 
            260                 265                 270         


Gly Val Leu Leu Gly Thr Thr Gln Leu Ser Ala Val Asn Ile Cys Thr 
        275                 280                 285             


Phe Arg Gly Asp Val Thr His Ile Ala Gly Ser His Asp Tyr Ile Met 
    290                 295                 300                 


Asn Leu Ala Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile 
305                 310                 315                 320 


Pro Ala Pro Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Met 
                325                 330                 335     


Leu Thr Gln Thr Thr Arg Glu Asp Gly Ser Thr Arg Ala His Lys Ala 
            340                 345                 350         


Thr Val Ser Thr Gly Ser Val His Phe Thr Pro Lys Leu Gly Ser Val 
        355                 360                 365             


Gln Tyr Thr Thr Asp Thr Asn Asn Asp Leu Gln Thr Gly Gln Asn Thr 
    370                 375                 380                 


Lys Phe Thr Pro Val Gly Val Ile Gln Asp Gly Asn Asn His Gln Asn 
385                 390                 395                 400 


Glu Pro Gln Gln Trp Val Leu Pro Asn Tyr Ser Gly Arg Thr Gly His 
                405                 410                 415     


Asn Val His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln 
            420                 425                 430         


Leu Leu Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn 
        435                 440                 445             


Met Asn Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr 
    450                 455                 460                 


Gln Glu Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val 
465                 470                 475                 480 


Asn Pro Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser 
                485                 490                 495     


Gly Tyr Val Thr Val Ala His Thr Gly Pro His Asp Leu Val Ile Pro 
            500                 505                 510         


Pro Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr 
        515                 520                 525             


Leu Ala Pro Met Gly Asn Gly Ala Gly Arg 
    530                 535             


<210>  4
<211>  856
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-NoV P- (387)-NoV P- (207) fusion protein

<400>  4

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Val Pro Arg 
    210                 215                 220                 


Ser Arg Thr Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met 
225                 230                 235                 240 


Ser Asn Ser Arg Phe Pro Ile Pro Leu Glu Lys Leu Tyr Thr Gly Pro 
                245                 250                 255     


Ser Ser Ala Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp 
            260                 265                 270         


Gly Val Leu Leu Gly Thr Thr Gln Leu Ser Ala Val Asn Ile Cys Thr 
        275                 280                 285             


Phe Arg Gly Asp Val Thr His Ile Ala Gly Ser His Asp Tyr Ile Met 
    290                 295                 300                 


Asn Leu Ala Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile 
305                 310                 315                 320 


Pro Ala Pro Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Met 
                325                 330                 335     


Leu Thr Gln Thr Thr Arg Glu Asp Gly Ser Thr Arg Ala His Lys Ala 
            340                 345                 350         


Thr Val Ser Thr Gly Ser Val His Phe Thr Pro Lys Leu Gly Ser Val 
        355                 360                 365             


Gln Tyr Thr Thr Asp Thr Asn Asn Asp Leu Gln Thr Gly Gln Asn Thr 
    370                 375                 380                 


Lys Phe Thr Pro Val Gly Val Ile Gln Asp Gly Asn Asn His Gln Asn 
385                 390                 395                 400 


Glu Pro Gln Gln Trp Val Leu Pro Asn Tyr Ser Gly Arg Thr Gly His 
                405                 410                 415     


Asn Val His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln 
            420                 425                 430         


Leu Leu Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn 
        435                 440                 445             


Met Asn Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr 
    450                 455                 460                 


Gln Glu Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val 
465                 470                 475                 480 


Asn Pro Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser 
                485                 490                 495     


Gly Tyr Val Thr Val Ala His Thr Gly Pro His Asp Leu Val Ile Pro 
            500                 505                 510         


Pro Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr 
        515                 520                 525             


Leu Ala Pro Met Gly Asn Gly Ala Gly Arg Gly Gly Gly Gly Gly Gly 
    530                 535                 540                 


Ser Lys Thr Lys Ala Phe Thr Ile Pro Val Leu Lys Ile Ser Glu Met 
545                 550                 555                 560 


Thr Asn Ser Arg Phe Pro Val Pro Val Asp Gln Met Tyr Thr Ser Arg 
                565                 570                 575     


Ser Glu Gly Ile Val Val Gln Pro Gln Asn Gly Arg Ala Thr Ile Asp 
            580                 585                 590         


Gly Glu Leu Leu Gly Thr Thr Leu Val Ser Pro Val Ser Val Cys Asn 
        595                 600                 605             


Phe Lys Gly Asn Leu Gln Ala Glu Val Pro Gly Gln His Gln Leu Tyr 
    610                 615                 620                 


Gln Leu Gln Leu Thr Asn Leu Asp Gly Ser Pro Ile Asp Pro Thr Asp 
625                 630                 635                 640 


Asp Thr Pro Gly Pro Leu Gly Cys Pro Asp Phe Thr Gly Leu Leu Tyr 
                645                 650                 655     


Gly Val Ala Ser Gln Arg Gly Pro Gly Asp Ala Thr Arg Ala His Glu 
            660                 665                 670         


Ala Arg Ile Asp Thr Gly Ser Asp Thr Phe Ala Pro Lys Ile Gly Gln 
        675                 680                 685             


Val Arg Phe Tyr Ser Thr Ser Ser Asp Phe Glu Thr Asn Gln Pro Thr 
    690                 695                 700                 


His Phe Thr Pro Ile Gly Ile Tyr Ile Glu Gly Asn Ser Ser Asp Phe 
705                 710                 715                 720 


Asn Gln Trp Gln Leu Pro Arg Tyr Gly Gly His Leu Ala Asn Asn Asn 
                725                 730                 735     


His Leu Ala Pro Ala Val Ser Pro Leu Phe Pro Gly Glu Gln Ile Leu 
            740                 745                 750         


Phe Phe Arg Ser Phe Ile Pro Gly Ala Ser Gly His Thr Asn Gly Glu 
        755                 760                 765             


Met Asp Cys Leu Leu Pro Gln Glu Phe Val Gln His Phe Tyr Gln Glu 
    770                 775                 780                 


Ala Ala Thr Ala Arg Ser Glu Val Ala Leu Leu Arg Phe Val Asn Pro 
785                 790                 795                 800 


Asp Thr Gly Arg Ala Leu Phe Glu Ser Lys Leu His Lys Gln Gly Phe 
                805                 810                 815     


Met Thr Ile Ala Ser Ser Gly Asp His Pro Ile Ile Met Pro Thr Asn 
            820                 825                 830         


Gly Tyr Phe Arg Phe Glu Ala Trp Val Asn Gln Phe Tyr Ser Leu Ala 
        835                 840                 845             


Pro Val Gly Thr Gly Ser Gly Arg 
    850                 855     


<210>  5
<211>  866
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-NoV P- (387)-NoV P- (115) fusion protein

<400>  5

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Val Pro Arg 
    210                 215                 220                 


Ser Arg Thr Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met 
225                 230                 235                 240 


Ser Asn Ser Arg Phe Pro Ile Pro Leu Glu Lys Leu Tyr Thr Gly Pro 
                245                 250                 255     


Ser Ser Ala Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp 
            260                 265                 270         


Gly Val Leu Leu Gly Thr Thr Gln Leu Ser Ala Val Asn Ile Cys Thr 
        275                 280                 285             


Phe Arg Gly Asp Val Thr His Ile Ala Gly Ser His Asp Tyr Ile Met 
    290                 295                 300                 


Asn Leu Ala Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile 
305                 310                 315                 320 


Pro Ala Pro Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Met 
                325                 330                 335     


Leu Thr Gln Thr Thr Arg Glu Asp Gly Ser Thr Arg Ala His Lys Ala 
            340                 345                 350         


Thr Val Ser Thr Gly Ser Val His Phe Thr Pro Lys Leu Gly Ser Val 
        355                 360                 365             


Gln Tyr Thr Thr Asp Thr Asn Asn Asp Leu Gln Thr Gly Gln Asn Thr 
    370                 375                 380                 


Lys Phe Thr Pro Val Gly Val Ile Gln Asp Gly Asn Asn His Gln Asn 
385                 390                 395                 400 


Glu Pro Gln Gln Trp Val Leu Pro Asn Tyr Ser Gly Arg Thr Gly His 
                405                 410                 415     


Asn Val His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln 
            420                 425                 430         


Leu Leu Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn 
        435                 440                 445             


Met Asn Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr 
    450                 455                 460                 


Gln Glu Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val 
465                 470                 475                 480 


Asn Pro Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser 
                485                 490                 495     


Gly Tyr Val Thr Val Ala His Thr Gly Pro His Asp Leu Val Ile Pro 
            500                 505                 510         


Pro Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr 
        515                 520                 525             


Leu Ala Pro Met Gly Asn Gly Ala Gly Arg Gly Gly Gly Gly Gly Gly 
    530                 535                 540                 


Gly Gly Gly Gly Gly Gly Gln Lys Thr Lys Pro Phe Ser Val Pro Asn 
545                 550                 555                 560 


Leu Pro Leu Asn Thr Leu Ser Asn Ser Arg Val Pro Ser Leu Ile Arg 
                565                 570                 575     


Ser Met Met Val Ser Arg Asp His Gly Gln Met Val Gln Phe Gln Asn 
            580                 585                 590         


Gly Arg Val Thr Leu Asp Gly Gln Leu Gln Gly Thr Thr Pro Thr Ser 
        595                 600                 605             


Ala Ser Gln Leu Cys Lys Ile Arg Gly Ser Val Phe His Ala Asn Gly 
    610                 615                 620                 


Gly Asn Gly Tyr Thr Leu Thr Glu Leu Asp Gly Ser Pro Tyr His Ala 
625                 630                 635                 640 


Phe Glu Ser Pro Ala Pro Ile Gly Phe Pro Asp Leu Gly Glu Cys Asp 
                645                 650                 655     


Trp His Met Glu Ala Ser Pro Thr Thr Gln Phe Asp Thr Gly Asp Val 
            660                 665                 670         


Ile Lys Gln Ile Asn Val Lys Gln Glu Ala Ala Phe Ala Pro His Leu 
        675                 680                 685             


Gly Thr Ile Gln Ala Asp Gly Leu Ser Asp Val Ser Val Asn Thr Asn 
    690                 695                 700                 


Met Ile Ala Lys Leu Gly Trp Val Ser Pro Ala Ser Asp Gly His Arg 
705                 710                 715                 720 


Gly Asn Val Asp Pro Trp Val Ile Pro Arg Tyr Gly Ser Thr Leu Thr 
                725                 730                 735     


Glu Ala Ala Gln Leu Ala Pro Pro Ile Tyr Pro Pro Gly Phe Gly Glu 
            740                 745                 750         


Ala Ile Val Phe Phe Met Ser Asp Phe Pro Ile Ala His Gly Ala Asn 
        755                 760                 765             


Gly Leu Ser Val Pro Cys Thr Ile Pro Gln Glu Phe Val Thr His Phe 
    770                 775                 780                 


Val Asn Glu Gln Ala Pro Thr Arg Gly Glu Ala Ala Leu Leu His Tyr 
785                 790                 795                 800 


Leu Asp Pro Asp Thr His Arg Asn Leu Gly Glu Phe Lys Leu Tyr Pro 
                805                 810                 815     


Glu Gly Phe Met Thr Cys Val Pro Asn Ser Ser Gly Thr Gly Pro Gln 
            820                 825                 830         


Thr Leu Pro Ile Asn Gly Val Phe Val Phe Val Ser Trp Val Ser Arg 
        835                 840                 845             


Phe Tyr Gln Leu Lys Pro Val Gly Thr Ala Gly Pro Ala Arg Ser Leu 
    850                 855                 860                 


Gly Ile 
865     


<210>  6
<211>  638
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NoV P- (387)-NoV P- (207)  fusion protein

<400>  6

Ser Arg Thr Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met 
1               5                   10                  15      


Ser Asn Ser Arg Phe Pro Ile Pro Leu Glu Lys Leu Tyr Thr Gly Pro 
            20                  25                  30          


Ser Ser Ala Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp 
        35                  40                  45              


Gly Val Leu Leu Gly Thr Thr Gln Leu Ser Ala Val Asn Ile Cys Thr 
    50                  55                  60                  


Phe Arg Gly Asp Val Thr His Ile Ala Gly Ser His Asp Tyr Ile Met 
65                  70                  75                  80  


Asn Leu Ala Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile 
                85                  90                  95      


Pro Ala Pro Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Met 
            100                 105                 110         


Leu Thr Gln Thr Thr Arg Glu Asp Gly Ser Thr Arg Ala His Lys Ala 
        115                 120                 125             


Thr Val Ser Thr Gly Ser Val His Phe Thr Pro Lys Leu Gly Ser Val 
    130                 135                 140                 


Gln Tyr Thr Thr Asp Thr Asn Asn Asp Leu Gln Thr Gly Gln Asn Thr 
145                 150                 155                 160 


Lys Phe Thr Pro Val Gly Val Ile Gln Asp Gly Asn Asn His Gln Asn 
                165                 170                 175     


Glu Pro Gln Gln Trp Val Leu Pro Asn Tyr Ser Gly Arg Thr Gly His 
            180                 185                 190         


Asn Val His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln 
        195                 200                 205             


Leu Leu Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn 
    210                 215                 220                 


Met Asn Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr 
225                 230                 235                 240 


Gln Glu Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val 
                245                 250                 255     


Asn Pro Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser 
            260                 265                 270         


Gly Tyr Val Thr Val Ala His Thr Gly Pro His Asp Leu Val Ile Pro 
        275                 280                 285             


Pro Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr 
    290                 295                 300                 


Leu Ala Pro Met Gly Asn Gly Ala Gly Arg Gly Gly Gly Gly Gly Gly 
305                 310                 315                 320 


Gly Gly Gly Gly Gly Gly Ser Lys Thr Lys Ala Phe Thr Ile Pro Val 
                325                 330                 335     


Leu Lys Ile Ser Glu Met Thr Asn Ser Arg Phe Pro Val Pro Val Asp 
            340                 345                 350         


Gln Met Tyr Thr Ser Arg Ser Glu Gly Ile Val Val Gln Pro Gln Asn 
        355                 360                 365             


Gly Arg Ala Thr Ile Asp Gly Glu Leu Leu Gly Thr Thr Leu Val Ser 
    370                 375                 380                 


Pro Val Ser Val Cys Asn Phe Lys Gly Asn Leu Gln Ala Glu Val Pro 
385                 390                 395                 400 


Gly Gln His Gln Leu Tyr Gln Leu Gln Leu Thr Asn Leu Asp Gly Ser 
                405                 410                 415     


Pro Ile Asp Pro Thr Asp Asp Thr Pro Gly Pro Leu Gly Cys Pro Asp 
            420                 425                 430         


Phe Thr Gly Leu Leu Tyr Gly Val Ala Ser Gln Arg Gly Pro Gly Asp 
        435                 440                 445             


Ala Thr Arg Ala His Glu Ala Arg Ile Asp Thr Gly Ser Asp Thr Phe 
    450                 455                 460                 


Ala Pro Lys Ile Gly Gln Val Arg Phe Tyr Ser Thr Ser Ser Asp Phe 
465                 470                 475                 480 


Glu Thr Asn Gln Pro Thr His Phe Thr Pro Ile Gly Ile Tyr Ile Glu 
                485                 490                 495     


Gly Asn Ser Ser Asp Phe Asn Gln Trp Gln Leu Pro Arg Tyr Gly Gly 
            500                 505                 510         


His Leu Ala Asn Asn Asn His Leu Ala Pro Ala Val Ser Pro Leu Phe 
        515                 520                 525             


Pro Gly Glu Gln Ile Leu Phe Phe Arg Ser Phe Ile Pro Gly Ala Ser 
    530                 535                 540                 


Gly His Thr Asn Gly Glu Met Asp Cys Leu Leu Pro Gln Glu Phe Val 
545                 550                 555                 560 


Gln His Phe Tyr Gln Glu Ala Ala Thr Ala Arg Ser Glu Val Ala Leu 
                565                 570                 575     


Leu Arg Phe Val Asn Pro Asp Thr Gly Arg Ala Leu Phe Glu Ser Lys 
            580                 585                 590         


Leu His Lys Gln Gly Phe Met Thr Ile Ala Ser Ser Gly Asp His Pro 
        595                 600                 605             


Ile Ile Met Pro Thr Asn Gly Tyr Phe Arg Phe Glu Ala Trp Val Asn 
    610                 615                 620                 


Gln Phe Tyr Ser Leu Ala Pro Val Gly Thr Gly Ser Gly Arg 
625                 630                 635             


<210>  7
<211>  642
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NoV P- (387)-NoV P- (115) fusion protein

<400>  7

Ser Arg Thr Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met 
1               5                   10                  15      


Ser Asn Ser Arg Phe Pro Ile Pro Leu Glu Lys Leu Tyr Thr Gly Pro 
            20                  25                  30          


Ser Ser Ala Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp 
        35                  40                  45              


Gly Val Leu Leu Gly Thr Thr Gln Leu Ser Ala Val Asn Ile Cys Thr 
    50                  55                  60                  


Phe Arg Gly Asp Val Thr His Ile Ala Gly Ser His Asp Tyr Ile Met 
65                  70                  75                  80  


Asn Leu Ala Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile 
                85                  90                  95      


Pro Ala Pro Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Met 
            100                 105                 110         


Leu Thr Gln Thr Thr Arg Glu Asp Gly Ser Thr Arg Ala His Lys Ala 
        115                 120                 125             


Thr Val Ser Thr Gly Ser Val His Phe Thr Pro Lys Leu Gly Ser Val 
    130                 135                 140                 


Gln Tyr Thr Thr Asp Thr Asn Asn Asp Leu Gln Thr Gly Gln Asn Thr 
145                 150                 155                 160 


Lys Phe Thr Pro Val Gly Val Ile Gln Asp Gly Asn Asn His Gln Asn 
                165                 170                 175     


Glu Pro Gln Gln Trp Val Leu Pro Asn Tyr Ser Gly Arg Thr Gly His 
            180                 185                 190         


Asn Val His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln 
        195                 200                 205             


Leu Leu Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn 
    210                 215                 220                 


Met Asn Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr 
225                 230                 235                 240 


Gln Glu Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val 
                245                 250                 255     


Asn Pro Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser 
            260                 265                 270         


Gly Tyr Val Thr Val Ala His Thr Gly Pro His Asp Leu Val Ile Pro 
        275                 280                 285             


Pro Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr 
    290                 295                 300                 


Leu Ala Pro Met Gly Asn Gly Ala Gly Arg Gly Gly Gly Gly Gly Gly 
305                 310                 315                 320 


Gly Gly Gly Gly Gly Gly Gln Lys Thr Lys Pro Phe Ser Val Pro Asn 
                325                 330                 335     


Leu Pro Leu Asn Thr Leu Ser Asn Ser Arg Val Pro Ser Leu Ile Arg 
            340                 345                 350         


Ser Met Met Val Ser Arg Asp His Gly Gln Met Val Gln Phe Gln Asn 
        355                 360                 365             


Gly Arg Val Thr Leu Asp Gly Gln Leu Gln Gly Thr Thr Pro Thr Ser 
    370                 375                 380                 


Ala Ser Gln Leu Cys Lys Ile Arg Gly Ser Val Phe His Ala Asn Gly 
385                 390                 395                 400 


Gly Asn Gly Tyr Thr Leu Thr Glu Leu Asp Gly Ser Pro Tyr His Ala 
                405                 410                 415     


Phe Glu Ser Pro Ala Pro Ile Gly Phe Pro Asp Leu Gly Glu Cys Asp 
            420                 425                 430         


Trp His Met Glu Ala Ser Pro Thr Thr Gln Phe Asp Thr Gly Asp Val 
        435                 440                 445             


Ile Lys Gln Ile Asn Val Lys Gln Glu Ala Ala Phe Ala Pro His Leu 
    450                 455                 460                 


Gly Thr Ile Gln Ala Asp Gly Leu Ser Asp Val Ser Val Asn Thr Asn 
465                 470                 475                 480 


Met Ile Ala Lys Leu Gly Trp Val Ser Pro Ala Ser Asp Gly His Arg 
                485                 490                 495     


Gly Asn Val Asp Pro Trp Val Ile Pro Arg Tyr Gly Ser Thr Leu Thr 
            500                 505                 510         


Glu Ala Ala Gln Leu Ala Pro Pro Ile Tyr Pro Pro Gly Phe Gly Glu 
        515                 520                 525             


Ala Ile Val Phe Phe Met Ser Asp Phe Pro Ile Ala His Gly Ala Asn 
    530                 535                 540                 


Gly Leu Ser Val Pro Cys Thr Ile Pro Gln Glu Phe Val Thr His Phe 
545                 550                 555                 560 


Val Asn Glu Gln Ala Pro Thr Arg Gly Glu Ala Ala Leu Leu His Tyr 
                565                 570                 575     


Leu Asp Pro Asp Thr His Arg Asn Leu Gly Glu Phe Lys Leu Tyr Pro 
            580                 585                 590         


Glu Gly Phe Met Thr Cys Val Pro Asn Ser Ser Gly Thr Gly Pro Gln 
        595                 600                 605             


Thr Leu Pro Ile Asn Gly Val Phe Val Phe Val Ser Trp Val Ser Arg 
    610                 615                 620                 


Phe Tyr Gln Leu Lys Pro Val Gly Thr Ala Gly Pro Ala Arg Ser Leu 
625                 630                 635                 640 


Gly Ile 
        


<210>  8
<211>  696
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-NoV P- -VP8* (loop 2)

<400>  8

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Val Pro Arg 
    210                 215                 220                 


Ser Arg Thr Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met 
225                 230                 235                 240 


Ser Asn Ser Arg Phe Pro Ile Pro Leu Glu Lys Leu Tyr Thr Gly Pro 
                245                 250                 255     


Ser Ser Ala Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp 
            260                 265                 270         


Gly Val Leu Leu Gly Thr Thr Gln Leu Ser Ala Val Asn Ile Cys Thr 
        275                 280                 285             


Phe Arg Gly Asp Val Thr His Ile Ala Gly Ser His Asp Tyr Ile Met 
    290                 295                 300                 


Asn Leu Ala Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile 
305                 310                 315                 320 


Pro Ala Pro Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Met 
                325                 330                 335     


Leu Thr Gln Thr Thr Arg Glu Asp Gly Ser Thr Arg Ala His Lys Ala 
            340                 345                 350         


Thr Val Ser Thr Gly Thr Val His Phe Thr Pro Lys Leu Gly Ser Val 
        355                 360                 365             


Gln Tyr Thr Thr Ser Leu Asp Gly Pro Tyr Gln Pro Thr Thr Phe Thr 
    370                 375                 380                 


Pro Pro Thr Asp Tyr Trp Ile Leu Ile Asn Ser Asn Thr Asn Gly Val 
385                 390                 395                 400 


Val Tyr Glu Ser Thr Asn Asn Ser Asp Phe Trp Thr Ala Val Ile Ala 
                405                 410                 415     


Val Glu Pro His Val Asn Pro Val Asp Arg Gln Tyr Asn Val Phe Gly 
            420                 425                 430         


Glu Asn Lys Gln Phe Asn Val Arg Asn Asp Ser Asp Lys Trp Lys Phe 
        435                 440                 445             


Leu Glu Met Phe Arg Gly Ser Ser Gln Asn Asp Phe Tyr Asn Arg Arg 
    450                 455                 460                 


Thr Leu Thr Ser Asp Thr Arg Leu Val Gly Ile Leu Lys Tyr Gly Gly 
465                 470                 475                 480 


Arg Ile Trp Thr Phe His Gly Glu Thr Pro Arg Ala Thr Thr Asp Ser 
                485                 490                 495     


Ser Asn Thr Ala Asn Leu Asn Gly Ile Ser Ile Thr Ile His Ser Glu 
            500                 505                 510         


Phe Tyr Ile Ile Pro Arg Ser Gln Glu Ser Lys Cys Asn Glu Tyr Ile 
        515                 520                 525             


Asn Asn Gly Leu Ile Asp Ile Leu Gln Thr Gly Gln Asn Thr Lys Phe 
    530                 535                 540                 


Thr Pro Val Gly Val Ile Gln Asp Gly Asn Asn His Gln Asn Glu Pro 
545                 550                 555                 560 


Gln Gln Trp Val Leu Pro Asn Tyr Ser Gly Arg Thr Gly His Asn Val 
                565                 570                 575     


His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu 
            580                 585                 590         


Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn Met Asn 
        595                 600                 605             


Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr Gln Glu 
    610                 615                 620                 


Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro 
625                 630                 635                 640 


Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr 
                645                 650                 655     


Val Thr Val Ala His Thr Gly Pro His Asp Leu Val Ile Pro Pro Asn 
            660                 665                 670         


Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala 
        675                 680                 685             


Pro Met Gly Asn Gly Ala Gly Arg 
    690                 695     


<210>  9
<211>  709
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-NoV P--VP8* (C-end)

<400>  9

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Val Pro Arg 
    210                 215                 220                 


Ser Arg Thr Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met 
225                 230                 235                 240 


Ser Asn Ser Arg Phe Pro Ile Pro Leu Glu Lys Leu Tyr Thr Gly Pro 
                245                 250                 255     


Ser Ser Ala Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp 
            260                 265                 270         


Gly Val Leu Leu Gly Thr Thr Gln Leu Ser Ala Val Asn Ile Cys Thr 
        275                 280                 285             


Phe Arg Gly Asp Val Thr His Ile Ala Gly Ser His Asp Tyr Ile Met 
    290                 295                 300                 


Asn Leu Ala Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile 
305                 310                 315                 320 


Pro Ala Pro Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Met 
                325                 330                 335     


Leu Thr Gln Thr Thr Arg Glu Asp Gly Ser Thr Arg Ala His Lys Ala 
            340                 345                 350         


Thr Val Ser Thr Gly Ser Val His Phe Thr Pro Lys Leu Gly Ser Val 
        355                 360                 365             


Gln Tyr Thr Thr Asp Thr Asn Asn Asp Leu Gln Thr Gly Gln Asn Thr 
    370                 375                 380                 


Lys Phe Thr Pro Val Gly Val Ile Gln Asp Gly Asn Asn His Gln Asn 
385                 390                 395                 400 


Glu Pro Gln Gln Trp Val Leu Pro Asn Tyr Ser Gly Arg Thr Gly His 
                405                 410                 415     


Asn Val His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln 
            420                 425                 430         


Leu Leu Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn 
        435                 440                 445             


Met Asn Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr 
    450                 455                 460                 


Gln Glu Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val 
465                 470                 475                 480 


Asn Pro Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser 
                485                 490                 495     


Gly Tyr Val Thr Val Ala His Thr Gly Pro His Asp Leu Val Ile Pro 
            500                 505                 510         


Pro Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr 
        515                 520                 525             


Leu Ala Pro Met Gly Asn Gly Ala Gly Arg Gly Gly Gly Gly Gly Gly 
    530                 535                 540                 


Gly Gly Gly Gly Gly Gly Leu Asp Gly Pro Tyr Gln Pro Thr Thr Phe 
545                 550                 555                 560 


Thr Pro Pro Thr Asp Tyr Trp Ile Leu Ile Asn Ser Asn Thr Asn Gly 
                565                 570                 575     


Val Val Tyr Glu Ser Thr Asn Asn Ser Asp Phe Trp Thr Ala Val Ile 
            580                 585                 590         


Ala Val Glu Pro His Val Asn Pro Val Asp Arg Gln Tyr Asn Val Phe 
        595                 600                 605             


Gly Glu Asn Lys Gln Phe Asn Val Arg Asn Asp Ser Asp Lys Trp Lys 
    610                 615                 620                 


Phe Leu Glu Met Phe Arg Gly Ser Ser Gln Asn Asp Phe Tyr Asn Arg 
625                 630                 635                 640 


Arg Thr Leu Thr Ser Asp Thr Arg Leu Val Gly Ile Leu Lys Tyr Gly 
                645                 650                 655     


Gly Arg Ile Trp Thr Phe His Gly Glu Thr Pro Arg Ala Thr Thr Asp 
            660                 665                 670         


Ser Ser Asn Thr Ala Asn Leu Asn Gly Ile Ser Ile Thr Ile His Ser 
        675                 680                 685             


Glu Phe Tyr Ile Ile Pro Arg Ser Gln Glu Ser Lys Cys Asn Glu Tyr 
    690                 695                 700                 


Ile Asn Asn Gly Leu 
705                 


<210>  10
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-NoV P--M2e (loop 2)

<400>  10

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Val Pro Arg 
    210                 215                 220                 


Ser Arg Thr Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met 
225                 230                 235                 240 


Ser Asn Ser Arg Phe Pro Ile Pro Leu Glu Lys Leu Tyr Thr Gly Pro 
                245                 250                 255     


Ser Ser Ala Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp 
            260                 265                 270         


Gly Val Leu Leu Gly Thr Thr Gln Leu Ser Ala Val Asn Ile Cys Thr 
        275                 280                 285             


Phe Arg Gly Asp Val Thr His Ile Ala Gly Ser His Asp Tyr Ile Met 
    290                 295                 300                 


Asn Leu Ala Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile 
305                 310                 315                 320 


Pro Ala Pro Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Met 
                325                 330                 335     


Leu Thr Gln Thr Thr Arg Glu Asp Gly Ser Thr Arg Ala His Lys Ala 
            340                 345                 350         


Thr Val Ser Thr Gly Thr Val His Phe Thr Pro Lys Leu Gly Ser Val 
        355                 360                 365             


Gln Tyr Thr Thr Ser Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg 
    370                 375                 380                 


Asn Glu Trp Gly Cys Arg Cys Asn Asp Ser Ser Asp Ile Asp Ile Leu 
385                 390                 395                 400 


Gln Thr Gly Gln Asn Thr Lys Phe Thr Pro Val Gly Val Ile Gln Asp 
                405                 410                 415     


Gly Asn Asn His Gln Asn Glu Pro Gln Gln Trp Val Leu Pro Asn Tyr 
            420                 425                 430         


Ser Gly Arg Thr Gly His Asn Val His Leu Ala Pro Ala Val Ala Pro 
        435                 440                 445             


Thr Phe Pro Gly Glu Gln Leu Leu Phe Phe Arg Ser Thr Met Pro Gly 
    450                 455                 460                 


Cys Ser Gly Tyr Pro Asn Met Asn Leu Asp Cys Leu Leu Pro Gln Glu 
465                 470                 475                 480 


Trp Val Gln His Phe Tyr Gln Glu Ala Ala Pro Ala Gln Ser Asp Val 
                485                 490                 495     


Ala Leu Leu Arg Phe Val Asn Pro Asp Thr Gly Arg Val Leu Phe Glu 
            500                 505                 510         


Cys Lys Leu His Lys Ser Gly Tyr Val Thr Val Ala His Thr Gly Pro 
        515                 520                 525             


His Asp Leu Val Ile Pro Pro Asn Gly Tyr Phe Arg Phe Asp Ser Trp 
    530                 535                 540                 


Val Asn Gln Phe Tyr Thr Leu Ala Pro Met Gly Asn Gly Ala Gly Arg 
545                 550                 555                 560 


<210>  11
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NoV P- -VP8* (C-end)

<400>  11

Ser Arg Thr Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met 
1               5                   10                  15      


Ser Asn Ser Arg Phe Pro Ile Pro Leu Glu Lys Leu Tyr Thr Gly Pro 
            20                  25                  30          


Ser Ser Ala Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp 
        35                  40                  45              


Gly Val Leu Leu Gly Thr Thr Gln Leu Ser Ala Val Asn Ile Cys Thr 
    50                  55                  60                  


Phe Arg Gly Asp Val Thr His Ile Ala Gly Ser His Asp Tyr Ile Met 
65                  70                  75                  80  


Asn Leu Ala Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile 
                85                  90                  95      


Pro Ala Pro Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Met 
            100                 105                 110         


Leu Thr Gln Thr Thr Arg Glu Asp Gly Ser Thr Arg Ala His Lys Ala 
        115                 120                 125             


Thr Val Ser Thr Gly Ser Val His Phe Thr Pro Lys Leu Gly Ser Val 
    130                 135                 140                 


Gln Tyr Thr Thr Asp Thr Asn Asn Asp Leu Gln Thr Gly Gln Asn Thr 
145                 150                 155                 160 


Lys Phe Thr Pro Val Gly Val Ile Gln Asp Gly Asn Asn His Gln Asn 
                165                 170                 175     


Glu Pro Gln Gln Trp Val Leu Pro Asn Tyr Ser Gly Arg Thr Gly His 
            180                 185                 190         


Asn Val His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln 
        195                 200                 205             


Leu Leu Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn 
    210                 215                 220                 


Met Asn Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr 
225                 230                 235                 240 


Gln Glu Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val 
                245                 250                 255     


Asn Pro Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser 
            260                 265                 270         


Gly Tyr Val Thr Val Ala His Thr Gly Pro His Asp Leu Val Ile Pro 
        275                 280                 285             


Pro Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr 
    290                 295                 300                 


Leu Ala Pro Met Gly Asn Gly Ala Gly Arg Gly Gly Gly Gly Gly Gly 
305                 310                 315                 320 


Gly Gly Gly Gly Gly Gly Leu Asp Gly Pro Tyr Gln Pro Thr Thr Phe 
                325                 330                 335     


Thr Pro Pro Thr Asp Tyr Trp Ile Leu Ile Asn Ser Asn Thr Asn Gly 
            340                 345                 350         


Val Val Tyr Glu Ser Thr Asn Asn Ser Asp Phe Trp Thr Ala Val Ile 
        355                 360                 365             


Ala Val Glu Pro His Val Asn Pro Val Asp Arg Gln Tyr Asn Val Phe 
    370                 375                 380                 


Gly Glu Asn Lys Gln Phe Asn Val Arg Asn Asp Ser Asp Lys Trp Lys 
385                 390                 395                 400 


Phe Leu Glu Met Phe Arg Gly Ser Ser Gln Asn Asp Phe Tyr Asn Arg 
                405                 410                 415     


Arg Thr Leu Thr Ser Asp Thr Arg Leu Val Gly Ile Leu Lys Tyr Gly 
            420                 425                 430         


Gly Arg Ile Trp Thr Phe His Gly Glu Thr Pro Arg Ala Thr Thr Asp 
        435                 440                 445             


Ser Ser Asn Thr Ala Asn Leu Asn Gly Ile Ser Ile Thr Ile His Ser 
    450                 455                 460                 


Glu Phe Tyr Ile Ile Pro Arg Ser Gln Glu Ser Lys Cys Asn Glu Tyr 
465                 470                 475                 480 


Ile Asn Asn Gly Leu 
                485 


<210>  12
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NoV P--M2e

<400>  12

Ser Arg Thr Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met 
1               5                   10                  15      


Ser Asn Ser Arg Phe Pro Ile Pro Leu Glu Lys Leu Tyr Thr Gly Pro 
            20                  25                  30          


Ser Ser Ala Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp 
        35                  40                  45              


Gly Val Leu Leu Gly Thr Thr Gln Leu Ser Ala Val Asn Ile Cys Thr 
    50                  55                  60                  


Phe Arg Gly Asp Val Thr His Ile Ala Gly Ser His Asp Tyr Ile Met 
65                  70                  75                  80  


Asn Leu Ala Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile 
                85                  90                  95      


Pro Ala Pro Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Met 
            100                 105                 110         


Leu Thr Gln Thr Thr Arg Glu Asp Gly Ser Thr Arg Ala His Lys Ala 
        115                 120                 125             


Thr Val Ser Thr Gly Thr Val His Phe Thr Pro Lys Leu Gly Ser Val 
    130                 135                 140                 


Gln Tyr Thr Thr Ser Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg 
145                 150                 155                 160 


Asn Glu Trp Gly Cys Arg Cys Asn Asp Ser Ser Asp Ile Asp Ile Leu 
                165                 170                 175     


Gln Thr Gly Gln Asn Thr Lys Phe Thr Pro Val Gly Val Ile Gln Asp 
            180                 185                 190         


Gly Asn Asn His Gln Asn Glu Pro Gln Gln Trp Val Leu Pro Asn Tyr 
        195                 200                 205             


Ser Gly Arg Thr Gly His Asn Val His Leu Ala Pro Ala Val Ala Pro 
    210                 215                 220                 


Thr Phe Pro Gly Glu Gln Leu Leu Phe Phe Arg Ser Thr Met Pro Gly 
225                 230                 235                 240 


Cys Ser Gly Tyr Pro Asn Met Asn Leu Asp Cys Leu Leu Pro Gln Glu 
                245                 250                 255     


Trp Val Gln His Phe Tyr Gln Glu Ala Ala Pro Ala Gln Ser Asp Val 
            260                 265                 270         


Ala Leu Leu Arg Phe Val Asn Pro Asp Thr Gly Arg Val Leu Phe Glu 
        275                 280                 285             


Cys Lys Leu His Lys Ser Gly Tyr Val Thr Val Ala His Thr Gly Pro 
    290                 295                 300                 


His Asp Leu Val Ile Pro Pro Asn Gly Tyr Phe Arg Phe Asp Ser Trp 
305                 310                 315                 320 


Val Asn Gln Phe Tyr Thr Leu Ala Pro Met Gly Asn Gly Ala Gly Arg 
                325                 330                 335     


<210>  13
<211>  778
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-NoV P-GST

<400>  13

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Val Pro Arg 
    210                 215                 220                 


Ser Arg Thr Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met 
225                 230                 235                 240 


Ser Asn Ser Arg Phe Pro Ile Pro Leu Glu Lys Leu Tyr Thr Gly Pro 
                245                 250                 255     


Ser Ser Ala Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp 
            260                 265                 270         


Gly Val Leu Leu Gly Thr Thr Gln Leu Ser Ala Val Asn Ile Cys Thr 
        275                 280                 285             


Phe Arg Gly Asp Val Thr His Ile Ala Gly Ser His Asp Tyr Ile Met 
    290                 295                 300                 


Asn Leu Ala Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile 
305                 310                 315                 320 


Pro Ala Pro Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Met 
                325                 330                 335     


Leu Thr Gln Thr Thr Arg Glu Asp Gly Ser Thr Arg Ala His Lys Ala 
            340                 345                 350         


Thr Val Ser Thr Gly Ser Val His Phe Thr Pro Lys Leu Gly Ser Val 
        355                 360                 365             


Gln Tyr Thr Thr Asp Thr Asn Asn Asp Leu Gln Thr Gly Gln Asn Thr 
    370                 375                 380                 


Lys Phe Thr Pro Val Gly Val Ile Gln Asp Gly Asn Asn His Gln Asn 
385                 390                 395                 400 


Glu Pro Gln Gln Trp Val Leu Pro Asn Tyr Ser Gly Arg Thr Gly His 
                405                 410                 415     


Asn Val His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln 
            420                 425                 430         


Leu Leu Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn 
        435                 440                 445             


Met Asn Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr 
    450                 455                 460                 


Gln Glu Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val 
465                 470                 475                 480 


Asn Pro Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser 
                485                 490                 495     


Gly Tyr Val Thr Val Ala His Thr Gly Pro His Asp Leu Val Ile Pro 
            500                 505                 510         


Pro Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr 
        515                 520                 525             


Leu Ala Pro Met Gly Asn Gly Ala Gly Arg Arg Arg Ala Leu Gly Gly 
    530                 535                 540                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Met Ser Pro Ile Leu Gly 
545                 550                 555                 560 


Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro Thr Arg Leu Leu Leu Glu 
                565                 570                 575     


Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu Tyr Glu Arg Asp Glu Gly 
            580                 585                 590         


Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu Gly Leu Glu Phe Pro Asn 
        595                 600                 605             


Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys Leu Thr Gln Ser Met Ala 
    610                 615                 620                 


Ile Ile Arg Tyr Ile Ala Asp Lys His Asn Met Leu Gly Gly Cys Pro 
625                 630                 635                 640 


Lys Glu Arg Ala Glu Ile Ser Met Leu Glu Gly Ala Val Leu Asp Ile 
                645                 650                 655     


Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser Lys Asp Phe Glu Thr Leu 
            660                 665                 670         


Lys Val Asp Phe Leu Ser Lys Leu Pro Glu Met Leu Lys Met Phe Glu 
        675                 680                 685             


Asp Arg Leu Cys His Lys Thr Tyr Leu Asn Gly Asp His Val Thr His 
    690                 695                 700                 


Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp Val Val Leu Tyr Met Asp 
705                 710                 715                 720 


Pro Met Cys Leu Asp Ala Phe Pro Lys Leu Val Cys Phe Lys Lys Arg 
                725                 730                 735     


Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr Leu Lys Ser Ser Lys Tyr 
            740                 745                 750         


Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala Thr Phe Gly Gly Gly Asp 
        755                 760                 765             


His Pro Pro Lys Ser Asp Leu Val Pro Arg 
    770                 775             


<210>  14
<211>  709
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-NoV P- - HEV P

<400>  14

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Val Pro Arg 
    210                 215                 220                 


Ser Arg Thr Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met 
225                 230                 235                 240 


Ser Asn Ser Arg Phe Pro Ile Pro Leu Glu Lys Leu Tyr Thr Gly Pro 
                245                 250                 255     


Ser Ser Ala Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp 
            260                 265                 270         


Gly Val Leu Leu Gly Thr Thr Gln Leu Ser Ala Val Asn Ile Cys Thr 
        275                 280                 285             


Phe Arg Gly Asp Val Thr His Ile Ala Gly Ser His Asp Tyr Ile Met 
    290                 295                 300                 


Asn Leu Ala Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile 
305                 310                 315                 320 


Pro Ala Pro Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Met 
                325                 330                 335     


Leu Thr Gln Thr Thr Arg Glu Asp Gly Ser Thr Arg Ala His Lys Ala 
            340                 345                 350         


Thr Val Ser Thr Gly Ser Val His Phe Thr Pro Lys Leu Gly Ser Val 
        355                 360                 365             


Gln Tyr Thr Thr Asp Thr Asn Asn Asp Leu Gln Thr Gly Gln Asn Thr 
    370                 375                 380                 


Lys Phe Thr Pro Val Gly Val Ile Gln Asp Gly Asn Asn His Gln Asn 
385                 390                 395                 400 


Glu Pro Gln Gln Trp Val Leu Pro Asn Tyr Ser Gly Arg Thr Gly His 
                405                 410                 415     


Asn Val His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln 
            420                 425                 430         


Leu Leu Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn 
        435                 440                 445             


Met Asn Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr 
    450                 455                 460                 


Gln Glu Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val 
465                 470                 475                 480 


Asn Pro Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser 
                485                 490                 495     


Gly Tyr Val Thr Val Ala His Thr Gly Pro His Asp Leu Val Ile Pro 
            500                 505                 510         


Pro Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr 
        515                 520                 525             


Leu Ala Pro Met Gly Asn Gly Ala Gly Arg Gly Gly Gly Gly Gly Gly 
    530                 535                 540                 


Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn 
545                 550                 555                 560 


Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr Asp Gln Thr Thr 
                565                 570                 575     


Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp Thr Val Thr Phe 
            580                 585                 590         


Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala Arg Ser Leu Asp Trp 
        595                 600                 605             


Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Thr Thr Ile Gln Gln Tyr 
    610                 615                 620                 


Ser Lys Thr Phe Tyr Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp 
625                 630                 635                 640 


Glu Ala Ser Thr Thr Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr 
                645                 650                 655     


Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly His Arg Val Ala 
            660                 665                 670         


Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ala Gly Pro Thr Ser Ile Ser 
        675                 680                 685             


Ala Val Gly Val Leu Ala Pro His Ser Ala Leu Ala Ala Leu Glu Asp 
    690                 695                 700                 


Thr Val Asp Tyr Pro 
705                 


<210>  15
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NoV P- -HEV P

<400>  15

Ser Arg Thr Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met 
1               5                   10                  15      


Ser Asn Ser Arg Phe Pro Ile Pro Leu Glu Lys Leu Tyr Thr Gly Pro 
            20                  25                  30          


Ser Ser Ala Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp 
        35                  40                  45              


Gly Val Leu Leu Gly Thr Thr Gln Leu Ser Ala Val Asn Ile Cys Thr 
    50                  55                  60                  


Phe Arg Gly Asp Val Thr His Ile Ala Gly Ser His Asp Tyr Ile Met 
65                  70                  75                  80  


Asn Leu Ala Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile 
                85                  90                  95      


Pro Ala Pro Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Met 
            100                 105                 110         


Leu Thr Gln Thr Thr Arg Glu Asp Gly Ser Thr Arg Ala His Lys Ala 
        115                 120                 125             


Thr Val Ser Thr Gly Ser Val His Phe Thr Pro Lys Leu Gly Ser Val 
    130                 135                 140                 


Gln Tyr Thr Thr Asp Thr Asn Asn Asp Leu Gln Thr Gly Gln Asn Thr 
145                 150                 155                 160 


Lys Phe Thr Pro Val Gly Val Ile Gln Asp Gly Asn Asn His Gln Asn 
                165                 170                 175     


Glu Pro Gln Gln Trp Val Leu Pro Asn Tyr Ser Gly Arg Thr Gly His 
            180                 185                 190         


Asn Val His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln 
        195                 200                 205             


Leu Leu Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn 
    210                 215                 220                 


Met Asn Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr 
225                 230                 235                 240 


Gln Glu Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val 
                245                 250                 255     


Asn Pro Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser 
            260                 265                 270         


Gly Tyr Val Thr Val Ala His Thr Gly Pro His Asp Leu Val Ile Pro 
        275                 280                 285             


Pro Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr 
    290                 295                 300                 


Leu Ala Pro Met Gly Asn Gly Ala Gly Arg Gly Gly Gly Gly Gly Gly 
305                 310                 315                 320 


Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn 
                325                 330                 335     


Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr Asp Gln Thr Thr 
            340                 345                 350         


Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp Thr Val Thr Phe 
        355                 360                 365             


Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala Arg Ser Leu Asp Trp 
    370                 375                 380                 


Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Thr Thr Ile Gln Gln Tyr 
385                 390                 395                 400 


Ser Lys Thr Phe Tyr Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp 
                405                 410                 415     


Glu Ala Ser Thr Thr Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr 
            420                 425                 430         


Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly His Arg Val Ala 
        435                 440                 445             


Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ala Gly Pro Thr Ser Ile Ser 
    450                 455                 460                 


Ala Val Gly Val Leu Ala Pro His Ser Ala Leu Ala Ala Leu Glu Asp 
465                 470                 475                 480 


Thr Val Asp Tyr Pro 
                485 


<210>  16
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEV P protein

<400>  16

Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn 
1               5                   10                  15      


Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr Asp Gln Thr Thr 
            20                  25                  30          


Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp Thr Val Thr Phe 
        35                  40                  45              


Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala Arg Ser Leu Asp Trp 
    50                  55                  60                  


Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Thr Thr Ile Gln Gln Tyr 
65                  70                  75                  80  


Ser Lys Thr Phe Tyr Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp 
                85                  90                  95      


Glu Ala Ser Thr Thr Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr 
            100                 105                 110         


Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly His Arg Val Ala 
        115                 120                 125             


Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ala Gly Pro Thr Ser Ile Ser 
    130                 135                 140                 


Ala Val Gly Val Leu Ala Pro His Ser Ala Leu Ala Ala Leu Glu Asp 
145                 150                 155                 160 


Thr Val Asp Tyr Pro Cys Asp Cys Arg Gly Asp Cys Phe Cys 
                165                 170                 


<210>  17
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Norovirus P domain (NoV P) of VA387

<400>  17

Ser Arg Thr Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met 
1               5                   10                  15      


Ser Asn Ser Arg Phe Pro Ile Pro Leu Glu Lys Leu Tyr Thr Gly Pro 
            20                  25                  30          


Ser Ser Ala Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp 
        35                  40                  45              


Gly Val Leu Leu Gly Thr Thr Gln Leu Ser Ala Val Asn Ile Cys Thr 
    50                  55                  60                  


Phe Arg Gly Asp Val Thr His Ile Ala Gly Ser His Asp Tyr Ile Met 
65                  70                  75                  80  


Asn Leu Ala Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile 
                85                  90                  95      


Pro Ala Pro Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Met 
            100                 105                 110         


Leu Thr Gln Thr Thr Arg Glu Asp Gly Ser Thr Arg Ala His Lys Ala 
        115                 120                 125             


Thr Val Ser Thr Gly Ser Val His Phe Thr Pro Lys Leu Gly Ser Val 
    130                 135                 140                 


Gln Tyr Thr Thr Asp Thr Asn Asn Asp Leu Gln Thr Gly Gln Asn Thr 
145                 150                 155                 160 


Lys Phe Thr Pro Val Gly Val Ile Gln Asp Gly Asn Asn His Gln Asn 
                165                 170                 175     


Glu Pro Gln Gln Trp Val Leu Pro Asn Tyr Ser Gly Arg Thr Gly His 
            180                 185                 190         


Asn Val His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln 
        195                 200                 205             


Leu Leu Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn 
    210                 215                 220                 


Met Asn Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr 
225                 230                 235                 240 


Gln Glu Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val 
                245                 250                 255     


Asn Pro Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser 
            260                 265                 270         


Gly Tyr Val Thr Val Ala His Thr Gly Pro His Asp Leu Val Ile Pro 
        275                 280                 285             


Pro Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr 
    290                 295                 300                 


Leu Ala Pro Met Gly Asn Gly Ala Gly Arg Arg Arg Ala Leu 
305                 310                 315             


<210>  18
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NoV P+ (VA387)

<400>  18

Ser Arg Thr Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met 
1               5                   10                  15      


Ser Asn Ser Arg Phe Pro Ile Pro Leu Glu Lys Leu Tyr Thr Gly Pro 
            20                  25                  30          


Ser Ser Ala Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp 
        35                  40                  45              


Gly Val Leu Leu Gly Thr Thr Gln Leu Ser Ala Val Asn Ile Cys Thr 
    50                  55                  60                  


Phe Arg Gly Asp Val Thr His Ile Ala Gly Ser His Asp Tyr Ile Met 
65                  70                  75                  80  


Asn Leu Ala Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile 
                85                  90                  95      


Pro Ala Pro Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Met 
            100                 105                 110         


Leu Thr Gln Thr Thr Arg Glu Asp Gly Ser Thr Arg Ala His Lys Ala 
        115                 120                 125             


Thr Val Ser Thr Gly Ser Val His Phe Thr Pro Lys Leu Gly Ser Val 
    130                 135                 140                 


Gln Tyr Thr Thr Asp Thr Asn Asn Asp Leu Gln Thr Gly Gln Asn Thr 
145                 150                 155                 160 


Lys Phe Thr Pro Val Gly Val Ile Gln Asp Gly Asn Asn His Gln Asn 
                165                 170                 175     


Glu Pro Gln Gln Trp Val Leu Pro Asn Tyr Ser Gly Arg Thr Gly His 
            180                 185                 190         


Asn Val His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln 
        195                 200                 205             


Leu Leu Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn 
    210                 215                 220                 


Met Asn Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr 
225                 230                 235                 240 


Gln Glu Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val 
                245                 250                 255     


Asn Pro Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser 
            260                 265                 270         


Gly Tyr Val Thr Val Ala His Thr Gly Pro His Asp Leu Val Ile Pro 
        275                 280                 285             


Pro Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr 
    290                 295                 300                 


Leu Ala Pro Met Gly Asn Gly Ala Gly Arg Arg Arg Ala Leu Cys Asp 
305                 310                 315                 320 


Cys Arg Gly Asp Cys Phe Cys 
                325         


<210>  19
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NoV P- (VA387)

<400>  19

Ser Arg Thr Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met 
1               5                   10                  15      


Ser Asn Ser Arg Phe Pro Ile Pro Leu Glu Lys Leu Tyr Thr Gly Pro 
            20                  25                  30          


Ser Ser Ala Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp 
        35                  40                  45              


Gly Val Leu Leu Gly Thr Thr Gln Leu Ser Ala Val Asn Ile Cys Thr 
    50                  55                  60                  


Phe Arg Gly Asp Val Thr His Ile Ala Gly Ser His Asp Tyr Ile Met 
65                  70                  75                  80  


Asn Leu Ala Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile 
                85                  90                  95      


Pro Ala Pro Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Met 
            100                 105                 110         


Leu Thr Gln Thr Thr Arg Glu Asp Gly Ser Thr Arg Ala His Lys Ala 
        115                 120                 125             


Thr Val Ser Thr Gly Ser Val His Phe Thr Pro Lys Leu Gly Ser Val 
    130                 135                 140                 


Gln Tyr Thr Thr Asp Thr Asn Asn Asp Leu Gln Thr Gly Gln Asn Thr 
145                 150                 155                 160 


Lys Phe Thr Pro Val Gly Val Ile Gln Asp Gly Asn Asn His Gln Asn 
                165                 170                 175     


Glu Pro Gln Gln Trp Val Leu Pro Asn Tyr Ser Gly Arg Thr Gly His 
            180                 185                 190         


Asn Val His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln 
        195                 200                 205             


Leu Leu Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn 
    210                 215                 220                 


Met Asn Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr 
225                 230                 235                 240 


Gln Glu Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val 
                245                 250                 255     


Asn Pro Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser 
            260                 265                 270         


Gly Tyr Val Thr Val Ala His Thr Gly Pro His Asp Leu Val Ile Pro 
        275                 280                 285             


Pro Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr 
    290                 295                 300                 


Leu Ala Pro Met Gly Asn Gly Ala Gly Arg 
305                 310                 


<210>  20
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST from Schistosoma Japonicum

<400>  20

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Val Pro Arg 
    210                 215                 220                 


<210>  21
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP8* (rotavirus)

<400>  21

Leu Asp Gly Pro Tyr Gln Pro Thr Thr Phe Thr Pro Pro Thr Asp Tyr 
1               5                   10                  15      


Trp Ile Leu Ile Asn Ser Asn Thr Asn Gly Val Val Tyr Glu Ser Thr 
            20                  25                  30          


Asn Asn Ser Asp Phe Trp Thr Ala Val Ile Ala Val Glu Pro His Val 
        35                  40                  45              


Asn Pro Val Asp Arg Gln Tyr Asn Val Phe Gly Glu Asn Lys Gln Phe 
    50                  55                  60                  


Asn Val Arg Asn Asp Ser Asp Lys Trp Lys Phe Leu Glu Met Phe Arg 
65                  70                  75                  80  


Gly Ser Ser Gln Asn Asp Phe Tyr Asn Arg Arg Thr Leu Thr Ser Asp 
                85                  90                  95      


Thr Arg Leu Val Gly Ile Leu Lys Tyr Gly Gly Arg Ile Trp Thr Phe 
            100                 105                 110         


His Gly Glu Thr Pro Arg Ala Thr Thr Asp Ser Ser Asn Thr Ala Asn 
        115                 120                 125             


Leu Asn Gly Ile Ser Ile Thr Ile His Ser Glu Phe Tyr Ile Ile Pro 
    130                 135                 140                 


Arg Ser Gln Glu Ser Lys Cys Asn Glu Tyr Ile Asn Asn Gly Leu 
145                 150                 155                 


<210>  22
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T cell epitope of NoV P of VA387:

<400>  22

His Phe Tyr Gln Glu Ala Ala Pro Ala Gln Ser Asp Val Ala Leu 
1               5                   10                  15  


<210>  23
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T Cell epitope of NoV P of VA207

<400>  23

Ala Thr Ala Arg Ser Glu Val Ala Leu Leu Arg Phe Val Asn Pro 
1               5                   10                  15  


<210>  24
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T Cell epitope of NoV P of VA115

<400>  24

Thr Leu Thr Glu Ala Ala Gln Leu Ala Pro Pro Ile Tyr Pro Pro 
1               5                   10                  15  


<210>  25
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NoV P- (VA207)

<400>  25

Ser Lys Thr Lys Ala Phe Thr Ile Pro Val Leu Lys Ile Ser Glu Met 
1               5                   10                  15      


Thr Asn Ser Arg Phe Pro Val Pro Val Asp Gln Met Tyr Thr Ser Arg 
            20                  25                  30          


Ser Glu Gly Ile Val Val Gln Pro Gln Asn Gly Arg Ala Thr Ile Asp 
        35                  40                  45              


Gly Glu Leu Leu Gly Thr Thr Leu Val Ser Pro Val Ser Val Cys Asn 
    50                  55                  60                  


Phe Lys Gly Asn Leu Gln Ala Glu Val Pro Gly Gln His Gln Leu Tyr 
65                  70                  75                  80  


Gln Leu Gln Leu Thr Asn Leu Asp Gly Ser Pro Ile Asp Pro Thr Asp 
                85                  90                  95      


Asp Thr Pro Gly Pro Leu Gly Cys Pro Asp Phe Thr Gly Leu Leu Tyr 
            100                 105                 110         


Gly Val Ala Ser Gln Arg Gly Pro Gly Asp Ala Thr Arg Ala His Glu 
        115                 120                 125             


Ala Arg Ile Asp Thr Gly Ser Asp Thr Phe Ala Pro Lys Ile Gly Gln 
    130                 135                 140                 


Val Arg Phe Tyr Ser Thr Ser Ser Asp Phe Glu Thr Asn Gln Pro Thr 
145                 150                 155                 160 


His Phe Thr Pro Ile Gly Ile Tyr Ile Glu Gly Asn Ser Ser Asp Phe 
                165                 170                 175     


Asn Gln Trp Gln Leu Pro Arg Tyr Gly Gly His Leu Ala Asn Asn Asn 
            180                 185                 190         


His Leu Ala Pro Ala Val Ser Pro Leu Phe Pro Gly Glu Gln Ile Leu 
        195                 200                 205             


Phe Phe Arg Ser Phe Ile Pro Gly Ala Ser Gly His Thr Asn Gly Glu 
    210                 215                 220                 


Met Asp Cys Leu Leu Pro Gln Glu Phe Val Gln His Phe Tyr Gln Glu 
225                 230                 235                 240 


Ala Ala Thr Ala Arg Ser Glu Val Ala Leu Leu Arg Phe Val Asn Pro 
                245                 250                 255     


Asp Thr Gly Arg Ala Leu Phe Glu Ser Lys Leu His Lys Gln Gly Phe 
            260                 265                 270         


Met Thr Ile Ala Ser Ser Gly Asp His Pro Ile Ile Met Pro Thr Asn 
        275                 280                 285             


Gly Tyr Phe Arg Phe Glu Ala Trp Val Asn Gln Phe Tyr Ser Leu Ala 
    290                 295                 300                 


Pro Val Gly Thr Gly Ser Gly Arg 
305                 310         


<210>  26
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NoV P- (VA115)

<400>  26

Gln Lys Thr Lys Pro Phe Ser Val Pro Asn Leu Pro Leu Asn Thr Leu 
1               5                   10                  15      


Ser Asn Ser Arg Val Pro Ser Leu Ile Arg Ser Met Met Val Ser Arg 
            20                  25                  30          


Asp His Gly Gln Met Val Gln Phe Gln Asn Gly Arg Val Thr Leu Asp 
        35                  40                  45              


Gly Gln Leu Gln Gly Thr Thr Pro Thr Ser Ala Ser Gln Leu Cys Lys 
    50                  55                  60                  


Ile Arg Gly Ser Val Phe His Ala Asn Gly Gly Asn Gly Tyr Thr Leu 
65                  70                  75                  80  


Thr Glu Leu Asp Gly Ser Pro Tyr His Ala Phe Glu Ser Pro Ala Pro 
                85                  90                  95      


Ile Gly Phe Pro Asp Leu Gly Glu Cys Asp Trp His Met Glu Ala Ser 
            100                 105                 110         


Pro Thr Thr Gln Phe Asp Thr Gly Asp Val Ile Lys Gln Ile Asn Val 
        115                 120                 125             


Lys Gln Glu Ala Ala Phe Ala Pro His Leu Gly Thr Ile Gln Ala Asp 
    130                 135                 140                 


Gly Leu Ser Asp Val Ser Val Asn Thr Asn Met Ile Ala Lys Leu Gly 
145                 150                 155                 160 


Trp Val Ser Pro Ala Ser Asp Gly His Arg Gly Asn Val Asp Pro Trp 
                165                 170                 175     


Val Ile Pro Arg Tyr Gly Ser Thr Leu Thr Glu Ala Ala Gln Leu Ala 
            180                 185                 190         


Pro Pro Ile Tyr Pro Pro Gly Phe Gly Glu Ala Ile Val Phe Phe Met 
        195                 200                 205             


Ser Asp Phe Pro Ile Ala His Gly Ala Asn Gly Leu Ser Val Pro Cys 
    210                 215                 220                 


Thr Ile Pro Gln Glu Phe Val Thr His Phe Val Asn Glu Gln Ala Pro 
225                 230                 235                 240 


Thr Arg Gly Glu Ala Ala Leu Leu His Tyr Leu Asp Pro Asp Thr His 
                245                 250                 255     


Arg Asn Leu Gly Glu Phe Lys Leu Tyr Pro Glu Gly Phe Met Thr Cys 
            260                 265                 270         


Val Pro Asn Ser Ser Gly Thr Gly Pro Gln Thr Leu Pro Ile Asn Gly 
        275                 280                 285             


Val Phe Val Phe Val Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys Pro 
    290                 295                 300                 


Val Gly Thr Ala Gly Pro Ala Arg Ser Leu Gly Ile 
305                 310                 315     


<210>  27
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P524

<400>  27
gcacggatcc tcaagaacta aaccattcac c                                      31


<210>  28
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P561

<400>  28
gcgtgcggcc gcttaccccg ctccatttcc catggg                                 36


<210>  29
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P590

<400>  29
gcatgcggcc gcttagcaaa agcaatcgcc acggcaatcg cataatgcac gtctgcgccc       60

cgc                                                                     63


<210>  30
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P821

<400>  30
gcacggatcc tcaaagacta aggcattcac                                        30


<210>  31
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P834

<400>  31
agtcgcggcc gcttagcgcc cacttccagt tcccac                                 36


<210>  32
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P843

<400>  32
gcacggatcc caaaagacta aaccatttag                                        30


<210>  33
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P846

<400>  33
gcatgcggcc gcttaacgag ccgggccggc tgttc                                  35


<210>  34
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P1572

<400>  34
atatcgtctc cccccgctcc atttcccatg                                        30


<210>  35
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P1573

<400>  35
tattcgtctc cgggggtgag caagggcga                                         29


<210>  36
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P1574

<400>  36
gcatgcggcc gcttacttgt acagctcgtc c                                      31


<210>  37
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P1617

<400>  37
atatcgtctc ccctccgcct ccgcctccgc cccccgctcc atttcc                      46


<210>  38
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P1618

<400>  38
tattcgtctc cgaggcggag gcggaggcgg atcaagaact aaacc                       45


<210>  39
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P1656

<400>  39
tattcgtctc cggggatcga gggaaggatt tcaatgtcac cgatacta                    48


<210>  40
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P1657

<400>  40
gcatgcggcc gcttaatccg attttggagg atggtcg                                37


<210>  41
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P1689

<400>  41
atacgcggat cctgcaacgg ccgttgctca agaactaaac cattcaccgt                  50


<210>  42
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P1734

<400>  42
atatcgtctc ctaatgcacg tctgcgcccc gc                                     32


<210>  43
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P1735

<400>  43
tattcgtctc cattattaga tggtccttat caacc                                  35


<210>  44
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P1736

<400>  44
gcatgcggcc gcttatagac cgttgttaat atattc                                 36


<210>  45
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P1955

<400>  45
tattcgtctc cgaggcggag gcggaggcgg acaaaagact aaaccattta g                51


<210>  46
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P1957

<400>  46
tattcgtctc cgaggcggag gcggaggcgg atcaaagact aaggcattca c                51


<210>  47
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P1958

<400>  47
gcatgcggcc gcttacccac ttccagttcc cacag                                  35


<210>  48
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P1985

<400>  48
atattattgc acggatcccc gaccccgtct ccggctc                                37


<210>  49
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P1986

<400>  49
gcatgcggcc gcttagcaaa agcaatcgcc acggcaatcg cacgggtagt caacggtgtc       60


<210>  50
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6 residue linker

<400>  50

Leu Val Pro Arg Gly Ser 
1               5       


<210>  51
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12 glycine linker

<400>  51

Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10          


<210>  52
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6 glycine linker

<400>  52

Gly Gly Gly Gly Gly Gly 
1               5       


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8 residue NoV hinge of NoV VP1

<400>  53

Phe Leu Val Pro Pro Thr Val Glu 
1               5               


<210>  54
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AstV P

<400>  54

Ser Ile Tyr Leu Pro Leu Pro Gln Ala Asp Asp Gln Tyr Thr Pro Tyr 
1               5                   10                  15      


Phe Val Tyr Asn Phe Gln Gly Glu Arg Val Ser Thr Thr Glu Thr Gly 
            20                  25                  30          


Val Phe Cys Leu Ala Ala Ile Pro Ala Ala Thr Thr Ser Ser Arg Tyr 
        35                  40                  45              


Asn Asn Gln Ile Thr Thr Pro Ser Ile Gly Tyr Arg Asn Ala Ser Gly 
    50                  55                  60                  


Thr Gly Thr Ser Phe Leu Leu Asp Ala Ala Ser Trp Trp Asn Ile Leu 
65                  70                  75                  80  


Asp Val Thr Gln Thr Gly Val Leu Phe Gly Gln Pro Arg Leu Gly Val 
                85                  90                  95      


Gly Val Met Gln Thr Met Lys Thr Leu Lys Gln His Ile Lys Asp Tyr 
            100                 105                 110         


Thr Glu Pro Ala Ile Gln Lys Tyr Tyr Pro Gly Thr Thr Asn Leu Asp 
        115                 120                 125             


Glu Gln Leu Lys Gln Arg Leu Asn Leu Ala Glu Gly Asp Pro Val Ile 
    130                 135                 140                 


Ser Met Gly Asp Thr Asn Gly Arg Arg Ala Ala Leu Phe Tyr Arg Thr 
145                 150                 155                 160 


Ser Asp Glu Lys Tyr Ile Leu Phe Phe Ser Thr Thr Glu Asp Pro Gly 
                165                 170                 175     


Ala Gln Tyr Gln Asn Leu Lys Met Leu Tyr Phe Trp Asn Trp Ser Tyr 
            180                 185                 190         


Ser Asp Thr Lys Gln Gln Phe Leu Asp His Leu Arg Thr Val Gln Phe 
        195                 200                 205             


<210>  55
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NoV P- -HEV P -AstV P

<400>  55

Ser Arg Thr Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met 
1               5                   10                  15      


Ser Asn Ser Arg Phe Pro Ile Pro Leu Glu Lys Leu Tyr Thr Gly Pro 
            20                  25                  30          


Ser Ser Ala Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp 
        35                  40                  45              


Gly Val Leu Leu Gly Thr Thr Gln Leu Ser Ala Val Asn Ile Cys Thr 
    50                  55                  60                  


Phe Arg Gly Asp Val Thr His Ile Ala Gly Ser His Asp Tyr Ile Met 
65                  70                  75                  80  


Asn Leu Ala Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile 
                85                  90                  95      


Pro Ala Pro Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Met 
            100                 105                 110         


Leu Thr Gln Thr Thr Arg Glu Asp Gly Ser Thr Arg Ala His Lys Ala 
        115                 120                 125             


Thr Val Ser Thr Gly Ser Val His Phe Thr Pro Lys Leu Gly Ser Val 
    130                 135                 140                 


Gln Tyr Thr Thr Asp Thr Asn Asn Asp Leu Gln Thr Gly Gln Asn Thr 
145                 150                 155                 160 


Lys Phe Thr Pro Val Gly Val Ile Gln Asp Gly Asn Asn His Gln Asn 
                165                 170                 175     


Glu Pro Gln Gln Trp Val Leu Pro Asn Tyr Ser Gly Arg Thr Gly His 
            180                 185                 190         


Asn Val His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln 
        195                 200                 205             


Leu Leu Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn 
    210                 215                 220                 


Met Asn Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr 
225                 230                 235                 240 


Gln Glu Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val 
                245                 250                 255     


Asn Pro Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser 
            260                 265                 270         


Gly Tyr Val Thr Val Ala His Thr Gly Pro His Asp Leu Val Ile Pro 
        275                 280                 285             


Pro Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr 
    290                 295                 300                 


Leu Ala Pro Met Gly Asn Gly Ala Gly Arg Gly Gly Gly Gly Gly Gly 
305                 310                 315                 320 


Gly Gly Gly Gly Gly Gly Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe 
                325                 330                 335     


Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala 
            340                 345                 350         


Glu Tyr Asp Gln Thr Thr Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val 
        355                 360                 365             


Ser Asp Thr Val Thr Phe Val Asn Val Ala Thr Gly Ala Gln Ala Val 
    370                 375                 380                 


Ala Arg Ser Leu Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu 
385                 390                 395                 400 


Thr Thr Ile Gln Gln Tyr Ser Lys Thr Phe Tyr Val Leu Pro Leu Arg 
                405                 410                 415     


Gly Lys Leu Ser Phe Trp Glu Ala Ser Thr Thr Lys Ala Gly Tyr Pro 
            420                 425                 430         


Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala 
        435                 440                 445             


Ala Gly His Arg Val Ala Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ala 
    450                 455                 460                 


Gly Pro Thr Ser Ile Ser Ala Val Gly Val Leu Ala Pro His Ser Ala 
465                 470                 475                 480 


Leu Ala Ala Leu Glu Asp Thr Val Asp Tyr Pro Cys Asp Cys Arg Gly 
                485                 490                 495     


Asp Cys Phe Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            500                 505                 510         


Ser Ile Tyr Leu Pro Leu Pro Gln Ala Asp Asp Gln Tyr Thr Pro Tyr 
        515                 520                 525             


Phe Val Tyr Asn Phe Gln Gly Glu Arg Val Ser Thr Thr Glu Thr Gly 
    530                 535                 540                 


Val Phe Cys Leu Ala Ala Ile Pro Ala Ala Thr Thr Ser Ser Arg Tyr 
545                 550                 555                 560 


Asn Asn Gln Ile Thr Thr Pro Ser Ile Gly Tyr Arg Asn Ala Ser Gly 
                565                 570                 575     


Thr Gly Thr Ser Phe Leu Leu Asp Ala Ala Ser Trp Trp Asn Ile Leu 
            580                 585                 590         


Asp Val Thr Gln Thr Gly Val Leu Phe Gly Gln Pro Arg Leu Gly Val 
        595                 600                 605             


Gly Val Met Gln Thr Met Lys Thr Leu Lys Gln His Ile Lys Asp Tyr 
    610                 615                 620                 


Thr Glu Pro Ala Ile Gln Lys Tyr Tyr Pro Gly Thr Thr Asn Leu Asp 
625                 630                 635                 640 


Glu Gln Leu Lys Gln Arg Leu Asn Leu Ala Glu Gly Asp Pro Val Ile 
                645                 650                 655     


Ser Met Gly Asp Thr Asn Gly Arg Arg Ala Ala Leu Phe Tyr Arg Thr 
            660                 665                 670         


Ser Asp Glu Lys Tyr Ile Leu Phe Phe Ser Thr Thr Glu Asp Pro Gly 
        675                 680                 685             


Ala Gln Tyr Gln Asn Leu Lys Met Leu Tyr Phe Trp Asn Trp Ser Tyr 
    690                 695                 700                 


Ser Asp Thr Lys Gln Gln Phe Leu Asp His Leu Arg Thr Val Gln Phe 
705                 710                 715                 720 


<210>  56
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AstV P -HEV P -VP8*

<400>  56

Ser Ile Tyr Leu Pro Leu Pro Gln Ala Asp Asp Gln Tyr Thr Pro Tyr 
1               5                   10                  15      


Phe Val Tyr Asn Phe Gln Gly Glu Arg Val Ser Thr Thr Glu Thr Gly 
            20                  25                  30          


Val Phe Cys Leu Ala Ala Ile Pro Ala Ala Thr Thr Ser Ser Arg Tyr 
        35                  40                  45              


Asn Asn Gln Ile Thr Thr Pro Ser Ile Gly Tyr Arg Asn Ala Ser Gly 
    50                  55                  60                  


Thr Gly Thr Ser Phe Leu Leu Asp Ala Ala Ser Trp Trp Asn Ile Leu 
65                  70                  75                  80  


Asp Val Thr Gln Thr Gly Val Leu Phe Gly Gln Pro Arg Leu Gly Val 
                85                  90                  95      


Gly Val Met Gln Thr Met Lys Thr Leu Lys Gln His Ile Lys Asp Tyr 
            100                 105                 110         


Thr Glu Pro Ala Ile Gln Lys Tyr Tyr Pro Gly Thr Thr Asn Leu Asp 
        115                 120                 125             


Glu Gln Leu Lys Gln Arg Leu Asn Leu Ala Glu Gly Asp Pro Val Ile 
    130                 135                 140                 


Ser Met Gly Asp Thr Asn Gly Arg Arg Ala Ala Leu Phe Tyr Arg Thr 
145                 150                 155                 160 


Ser Asp Glu Lys Tyr Ile Leu Phe Phe Ser Thr Thr Glu Asp Pro Gly 
                165                 170                 175     


Ala Gln Tyr Gln Asn Leu Lys Met Leu Tyr Phe Trp Asn Trp Ser Tyr 
            180                 185                 190         


Ser Asp Thr Lys Gln Gln Phe Leu Asp His Leu Arg Thr Val Gln Phe 
        195                 200                 205             


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Thr Pro Ser Pro 
    210                 215                 220                 


Ala Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp 
225                 230                 235                 240 


Leu Ser Leu Thr Ala Ala Glu Tyr Asp Gln Thr Thr Tyr Gly Ser Ser 
                245                 250                 255     


Thr Asn Pro Met Tyr Val Ser Asp Thr Val Thr Phe Val Asn Val Ala 
            260                 265                 270         


Thr Gly Ala Gln Ala Val Ala Arg Ser Leu Asp Trp Ser Lys Val Thr 
        275                 280                 285             


Leu Asp Gly Arg Pro Leu Thr Thr Ile Gln Gln Tyr Ser Lys Thr Phe 
    290                 295                 300                 


Tyr Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Ser Thr 
305                 310                 315                 320 


Thr Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln 
                325                 330                 335     


Ile Leu Ile Glu Asn Ala Ala Gly His Arg Val Ala Ile Ser Thr Tyr 
            340                 345                 350         


Thr Thr Ser Leu Gly Ala Gly Pro Thr Ser Ile Ser Ala Val Gly Val 
        355                 360                 365             


Leu Ala Pro His Ser Ala Leu Ala Ala Leu Glu Asp Thr Val Asp Tyr 
    370                 375                 380                 


Pro Cys Asp Cys Arg Gly Asp Cys Phe Cys Gly Gly Gly Gly Gly Gly 
385                 390                 395                 400 


Gly Gly Gly Gly Gly Gly Leu Asp Gly Pro Tyr Gln Pro Thr Thr Phe 
                405                 410                 415     


Thr Pro Pro Thr Asp Tyr Trp Ile Leu Ile Asn Ser Asn Thr Asn Gly 
            420                 425                 430         


Val Val Tyr Glu Ser Thr Asn Asn Ser Asp Phe Trp Thr Ala Val Ile 
        435                 440                 445             


Ala Val Glu Pro His Val Asn Pro Val Asp Arg Gln Tyr Asn Val Phe 
    450                 455                 460                 


Gly Glu Asn Lys Gln Phe Asn Val Arg Asn Asp Ser Asp Lys Trp Lys 
465                 470                 475                 480 


Phe Leu Glu Met Phe Arg Gly Ser Ser Gln Asn Asp Phe Tyr Asn Arg 
                485                 490                 495     


Arg Thr Leu Thr Ser Asp Thr Arg Leu Val Gly Ile Leu Lys Tyr Gly 
            500                 505                 510         


Gly Arg Ile Trp Thr Phe His Gly Glu Thr Pro Arg Ala Thr Thr Asp 
        515                 520                 525             


Ser Ser Asn Thr Ala Asn Leu Asn Gly Ile Ser Ile Thr Ile His Ser 
    530                 535                 540                 


Glu Phe Tyr Ile Ile Pro Arg Ser Gln Glu Ser Lys Cys Asn Glu Tyr 
545                 550                 555                 560 


Ile Asn Asn Gly Leu 
                565 


<210>  57
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M2e epitope

<400>  57

Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly Cys 
1               5                   10                  15      


Arg Cys Asn Asp Ser Ser Asp 
            20              


